Hub : Genes

EEF2K

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1420	0.0320	0.0e+00	0.234	0.198	0.227	0.211	0.228	3.9e-28	1.4e-23	3.5e-27	3.2e-25	2.2e-27
2	ROSMAP	Brain Pre-frontal Cortex	0.0863	0.0248	3.4e-09	0.097	0.087	0.080	0.089	0.088	1.8e-12	3.0e-11	1.9e-10	1.5e-11	2.3e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder (2018)	1.2	1.8	2.1	-1.4	-1.3
Bipolar Disorder or Schizophrenia	3.0	7.3	8.4	-2.5	-2.9
Depressed Affect (Nagel 2018)	0.2	0.4	0.7	0.9	0.1
Depression (Nagel 2018)	0.0	0.1	0.1	0.3	0.3
Intelligence (Savage-Jansen 2018)	3.0	9.3	10.6	3.2	2.9
Neuroticism (Nagel 2018)	0.3	0.7	1.3	1.1	0.3
Schizophrenia (2018)	2.8	5.8	7.1	-2.1	-2.7
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	0.5	0.5
Worry (Nagel 2018)	0.1	0.2	0.4	0.6	-0.1
Alzheimer’s Disease (in mother)	0.9	1.1	1.7	-0.8	-1.3
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.2	-0.6
Alzheimer’s Disease (including proxy)	1.4	2.0	2.8	-1.1	-1.7
Crohns Disease (2017)	0.0	0.0	0.0	0.1	-0.1
Irritable Bowel Disease (IBD)	0.1	0.1	0.1	-0.4	-0.4
Ulcerative Colitis (UC)	0.0	0.0	0.0	-0.1	-0.1
Major Depression (MDD)	0.2	0.3	0.5	0.2	-0.7
Reaction Time	1.0	1.9	2.6	1.6	1.1
Verbal and Numeric Reasoning (VNR)	3.7	8.8	9.0	3.0	2.9
Breast Cancer	0.1	0.2	0.2	0.4	0.5
Ovarian Cancer	0.1	0.1	0.1	0.4	-0.1
Prostate Cancer	0.5	0.7	1.1	-1.0	-0.6
Age at First Birth	0.0	0.0	0.0	0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.3	-0.3	0.6
Coronary Artery Disease (CAD)	0.3	0.4	0.6	0.4	0.8
Crohns Disease (2012)	0.7	1.2	1.8	-0.7	-1.4
Mean Putamen Volume	0.3	0.3	0.4	0.6	0.5
Fasting Glucose	0.9	1.0	1.8	-0.6	-1.3
HbA1C	1.4	1.5	1.9	-1.1	-1.4
HDL Cholesterol	1.7	2.9	3.1	-1.8	-1.6
LDL Cholesterol	0.1	0.1	0.2	0.5	-0.1
Lupus	0.1	0.2	0.3	0.6	0.0
Neuroticism (2016)	0.5	0.8	1.0	1.0	0.7
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.2	-0.2
Rheumatoid Arthritis	0.3	0.4	0.7	0.8	-0.2
Schizophrenia (2014)	2.6	5.8	6.2	-2.3	-2.5
Triglycerides	4.7	7.7	9.8	3.1	2.4
Type 2 Diabetes (T2D) (2012)	1.3	1.5	1.9	-1.4	-1.0
Ulcerative Colitis	1.6	2.4	2.7	-1.6	-1.4
Blood Eosinophil Count	0.1	0.5	0.7	0.9	0.5
Blood Platelet Count	0.1	1.3	1.6	-1.0	-1.3
Blood Red Count	0.1	1.2	1.8	0.7	1.4
Blood White Count	0.1	0.5	0.5	0.7	0.7
Heel T-Score	3.5	27.8	28.0	-5.3	-5.2
BMI	0.0	0.2	0.3	-0.4	-0.6
Height	0.1	1.7	2.1	-1.4	-1.2
Waist Hip Ratio (WHR)	0.3	1.4	1.9	1.0	1.4
Systolic Blood Pressure	0.1	0.5	0.8	0.5	0.9
Smoking Status	0.3	0.8	1.4	-1.2	-0.4
Allergy or Eczema	0.1	0.2	0.3	0.2	0.6
Cardiovascular Disease	0.3	1.1	1.2	-1.1	-0.9
Hypothyroidism (self reported)	0.6	1.3	1.4	-1.2	-1.1
Respiratory disease	1.5	3.4	4.3	-1.6	-2.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.3	0.2
Lung FEV1/FVC ratio	0.6	3.3	3.6	1.9	1.7
Lung FVC	0.0	0.0	0.0	0.1	-0.1
Neuroticism	0.2	0.5	0.9	0.9	0.3
Chronotype (morning person)	0.1	0.2	0.3	0.2	0.5
Hair Pigment	0.0	0.1	0.1	-0.4	-0.3
Tanning	0.1	0.9	1.3	1.1	0.7
Hand grip strength (left)	0.2	0.6	0.8	0.9	0.7
Number of treatments/medications taken	0.9	1.5	1.7	-1.3	-1.1
Average weekly spirits intake	0.1	0.2	0.3	0.2	0.6
Sensitivity / hurt feelings	0.6	1.0	1.4	1.2	0.8
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.2	0.4
Hearing difficulty/problems: Yes	0.3	0.5	0.8	-0.9	-0.5
Relative age of first facial hair	0.9	1.8	2.9	-0.8	-1.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	-0.3	0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.3	0.4
Ever had hysterectomy (womb removed)	1.6	1.8	2.0	-1.4	-1.2
Systolic blood pressure, automated reading	0.2	0.6	0.9	0.6	0.9
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.2	-0.4
Angina	0.3	0.4	0.7	0.4	0.8
Medication for hormone replacement therapy	0.5	0.6	0.9	0.9	0.5
Vitamin and mineral supplements	0.0	0.0	0.1	0.2	-0.2
Supplements: Zinc	2.2	2.4	2.5	-1.6	-1.5
Medication: Co-codamol	0.1	0.1	0.1	-0.4	-0.1
Medication: Metformin	0.0	0.0	0.0	0.2	0.0
Diabetes (father)	1.2	1.4	2.1	-0.9	-1.4
Diabetes (mother)	0.1	0.1	0.2	0.5	0.1
Severe depression (siblings)	0.1	0.1	0.2	0.4	0.2
Pack years adult smoking proportion	0.3	0.4	0.5	-0.7	-0.5
Impedance of leg (right)	1.4	6.7	6.7	-2.6	-2.6
Leg fat-free mass (left)	0.1	0.3	0.4	0.7	0.4
Trunk fat percentage	1.1	4.3	5.0	-2.2	-1.9
Hand grip strength (right)	0.6	1.8	1.9	1.4	1.3
Townsend deprivation index at recruitment	1.7	2.4	3.3	1.2	1.8
Current tobacco smoking	0.0	0.0	0.0	-0.2	0.2
Average weekly fortified wine intake	0.6	0.7	1.0	0.7	1.0
Maternal smoking around birth	0.8	1.2	1.8	-1.3	-0.7
Fed-up feelings	0.1	0.1	0.2	-0.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.5	0.7	0.7
Relative age voice broke	0.1	0.2	0.3	0.6	-0.3
Taking other prescription medications	1.4	2.1	2.3	-1.5	-1.4
Age when periods started (menarche)	0.0	0.0	0.0	-0.1	0.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	1.4	1.2	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.7	-0.4	-0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	0.7	0.8	0.8
Qualifications: CSEs or equivalent	1.2	1.6	2.5	-0.8	-1.6
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.2	0.1
High blood pressure	1.0	2.9	3.1	-1.8	-1.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.1	0.7
Multivitamins +/- minerals	0.4	0.5	0.7	0.5	0.8
Stomach or abdominal pain in last month	0.3	0.4	0.6	0.5	0.8
Supplements: Glucosamine	0.7	0.9	1.5	-0.5	-1.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.2	0.6
Medication: Atenolol	0.7	0.9	0.9	0.9	0.9
Medication: Levothyroxine sodium	0.2	0.3	0.4	-0.7	-0.4
Sitting height	0.4	3.0	3.3	1.8	1.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.3	0.6
High blood pressure (mother)	0.2	0.2	0.4	0.3	0.6
Body mass index (BMI)	0.1	0.5	0.5	-0.6	-0.7
Impedance of leg (left)	1.0	4.8	5.1	-2.3	-2.1
Leg predicted mass (left)	0.1	0.3	0.4	0.6	0.4
Trunk fat mass	0.6	2.8	3.0	-1.7	-1.6
Waist circumference	0.0	0.0	0.0	-0.1	0.1
Number of incorrect matches in round	0.0	0.0	0.0	-0.2	-0.1
Past tobacco smoking	0.2	0.4	0.8	0.9	-0.1
Alcohol usually taken with meals	0.9	1.5	1.5	-1.2	-1.2
Nervous feelings	0.3	0.5	0.7	0.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.2	-0.4
Hearing difficulty/problems with background noise	1.1	1.7	1.7	-1.3	-1.3
Hair/balding pattern: Pattern 2	1.4	1.8	3.0	1.7	0.8
Had menopause	0.7	0.9	1.8	-1.3	-0.0
Had other major operations	1.4	1.7	1.9	-1.4	-1.2
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.2	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.4	-0.9	-1.5
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	-0.0	-0.3
Qualifications: None of the above	0.3	0.6	1.1	-1.0	-0.4
Financial difficulties in last 2 years	1.0	1.4	1.7	1.3	1.1
Mouth/teeth dental problems	0.1	0.2	0.2	-0.5	-0.4
Heart attack	0.1	0.1	0.1	-0.1	0.3
Allergy	0.1	0.3	0.4	0.6	0.4
Pain all over the body in last month	0.1	0.1	0.2	0.5	-0.2
Diabetes (self-reported)	0.0	0.1	0.1	-0.3	0.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.0	-1.4	-0.1
Medication: Ramipril	1.8	2.3	3.5	-1.9	-1.1
Medication: Simvastatin	0.0	0.0	0.0	-0.1	-0.2
Fluid intelligence score	0.6	1.3	1.3	1.1	1.1
Illnesses of siblings	0.6	0.8	1.2	1.1	0.7
Neuroticism score	0.1	0.2	0.3	0.6	0.2
Weight	0.1	0.5	0.6	-0.6	-0.8
Impedance of arm (right)	1.4	6.7	8.5	-2.9	-2.2
Arm fat percentage (right)	1.0	4.0	4.3	-2.1	-1.9
Trunk fat-free mass	0.1	0.7	0.9	1.0	0.7
Hip circumference	0.2	0.9	1.1	-0.9	-1.1
Time employed in main current job	0.0	0.0	0.1	-0.0	0.2
Alcohol intake versus 10 years previously	0.5	0.7	1.1	0.6	1.0
Father’s age at death	2.2	2.9	3.4	-1.9	-1.5
Worrier / anxious feelings	2.1	4.0	4.3	1.9	2.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.5	1.2	0.5
Falls in the last year	0.3	0.4	0.7	0.2	-0.8
Hair/balding pattern: Pattern 3	0.8	1.1	1.9	-1.4	-0.6
Number of live births	2.1	3.0	3.9	-1.4	-2.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.5	0.7	-0.3
Pulse rate	0.1	0.1	0.2	-0.4	0.1
Happiness	1.3	1.6	1.6	1.3	1.3
Noisy workplace	0.7	0.8	1.1	-1.1	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.2	-0.3	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.2	1.5	0.6
Mouth/teeth dental problems: Dentures	0.5	0.8	1.0	1.0	0.8
Asthma	1.5	2.9	3.2	-1.6	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.8	-0.4	-1.3
Medication: Cholesterol lowering	0.4	0.6	0.7	-0.8	-0.7
Depression (self-reported)	0.6	0.7	1.2	1.1	0.4
Medication: Lansoprazole	0.3	0.3	0.4	-0.5	-0.6
Prospective memory result	0.5	0.7	0.8	-0.7	-0.9
Lung cancer (father)	1.6	1.9	2.4	1.5	1.2
Illnesses of mother	0.9	1.1	1.8	1.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	0.0	-0.9
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	0.3	0.8
Impedance of arm (left)	1.0	4.8	6.5	-2.5	-1.8
Arm fat mass (right)	0.6	2.4	2.4	-1.6	-1.5
Trunk predicted mass	0.1	0.8	1.0	1.0	0.7
Standing height	0.0	0.0	0.0	-0.2	-0.2
Length of working week for main job	0.3	0.3	0.6	0.2	0.8
Exposure to tobacco smoke at home	0.3	0.3	0.5	-0.7	-0.3
Breastfed as a baby	2.1	2.6	2.7	-1.6	-1.6
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.6	-0.6	-1.6
Hair/balding pattern: Pattern 4	2.2	5.3	6.2	2.1	2.5
Birth weight of first child	0.2	0.3	0.5	0.7	0.4
Peak expiratory flow (PEF)	0.2	0.4	0.7	-0.1	-0.8
Pulse wave reflection index	1.9	2.4	2.6	1.6	1.5
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.7	-0.7	-1.3
Loud music exposure frequency	0.1	0.1	0.2	-0.3	-0.4
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	3.6	1.9	1.1
Mouth/teeth dental problems: Bleeding gums	2.1	2.8	2.9	1.7	1.6
Blood clot in the leg (DVT)	0.6	0.8	0.9	1.0	0.9
Medication: Paracetamol	3.1	5.2	5.3	-2.3	-2.3
Headache pain in last month	0.5	0.8	0.9	-0.8	-1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	0.6	0.7	0.8
Glaucoma (self-reported)	1.0	1.2	1.7	0.8	1.3
Gout (self-reported)	0.5	0.8	1.4	0.3	1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	1.9	-1.0	-1.4
Medication: Amlodipine	0.6	0.9	1.1	0.8	1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.0	-1.0	-0.7
Birth weight	0.9	2.0	2.4	-1.3	-1.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	-0.9	-0.2
High blood pressure (siblings)	0.6	0.8	1.1	-1.1	-0.7
Forced vital capacity (FVC), Best measure	0.3	1.2	1.8	-0.8	-1.3
Body fat percentage	1.4	5.6	5.9	-2.4	-2.3
Leg fat percentage (right)	1.9	6.8	7.4	-2.5	-2.7
Arm fat-free mass (right)	0.2	1.0	1.4	1.2	0.8
Exposure to tobacco smoke outside home	0.5	0.7	1.0	-1.0	-0.6
Comparative body size at age 10	0.1	0.2	0.3	-0.4	-0.6
Number of full brothers	0.8	1.0	1.9	-0.2	-1.4
Worry too long after embarrassment	1.0	1.7	2.5	1.6	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.6	-0.4	-1.6
Wheeze or whistling in the chest in last year	1.2	2.2	3.2	-1.8	-1.1
Number of children fathered	1.5	1.7	1.8	-1.3	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	-0.1	0.2
Age at first live birth	0.5	0.9	1.7	1.3	0.3
Pulse wave peak to peak time	0.6	0.7	1.0	-0.5	-1.0
Health satisfaction	0.8	1.0	1.5	0.8	1.2
Shortness of breath walking on level ground	0.2	0.2	0.3	-0.3	-0.5
Qualifications: College or University degree	0.2	0.7	0.8	-0.7	-0.9
Eye problems/disorders: None of the above	0.7	0.9	1.0	0.8	1.0
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.1	-0.3	-0.2
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.0	0.2
Medication for pain relief, constipation, heartburn	2.7	4.6	5.5	2.0	2.3
Neck or shoulder pain in last month	0.1	0.1	0.2	0.2	0.5
Medication: Blood pressure	0.0	0.0	0.0	0.1	-0.2
Angina (self-reported)	0.3	0.4	0.6	0.3	0.8
Migraine (self-reported)	0.2	0.2	0.4	0.2	-0.6
Medication: Ibuprofen	1.0	1.1	2.2	-0.3	-1.5
Medication: Allopurinol	0.2	0.3	0.3	0.5	0.6
Medication: Omeprazole	0.1	0.2	0.2	-0.4	-0.4
Medication: Seretide 50 evohaler	0.8	0.9	1.2	0.7	1.1
Mean time to correctly identify matches	0.4	0.8	0.9	0.9	0.9
Heart disease (mother)	6.2	7.6	8.4	-2.9	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	1.5	1.2	1.1
Whole body fat mass	0.5	2.3	2.3	-1.5	-1.5
Leg fat mass (right)	0.9	3.3	4.0	-1.6	-2.0
Arm predicted mass (right)	0.2	1.1	1.5	1.2	0.8
Pulse rate, automated reading	0.0	0.0	0.0	-0.0	0.2
Alcohol intake frequency.	3.1	7.2	7.7	2.6	2.8
Comparative height size at age 10	0.1	0.4	0.6	0.8	0.5
Number of full sisters	2.2	2.6	3.6	-1.3	-1.9
Suffer from ‘nerves’	0.1	0.2	0.3	0.5	-0.4
Overall health rating	0.7	1.5	2.0	1.0	1.4
Chest pain or discomfort	2.6	3.8	5.3	-2.3	-1.5
Had major operations	1.7	2.0	2.3	-1.5	-1.2
Age at last live birth	0.8	1.1	2.0	1.4	0.5
Family relationship satisfaction	0.2	0.2	0.4	-0.3	-0.6
Leg pain on walking	1.5	1.8	2.0	-1.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	0.7	0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	-0.0	0.9
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.3	-1.1	-0.8
Medication: Aspirin	0.5	0.6	0.9	-0.6	-0.9
Supplements: Vitamin C	0.0	0.0	0.0	-0.1	-0.1
Knee pain experienced in last month	1.6	2.4	2.5	1.5	1.6
Hypertension (Self-reported)	0.9	2.6	2.9	-1.7	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	-0.1	-0.3
Illnesses of father: Heart disease	0.5	0.7	1.0	-0.6	-1.0
Illnesses of siblings: Diabetes	0.9	1.1	1.2	-1.1	-1.0
Smoking status: Previous	0.2	0.4	0.7	-0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.0	-0.6	-1.0
Whole body fat-free mass	0.1	0.8	1.0	1.0	0.8
Leg fat-free mass (right)	0.2	0.9	1.0	1.0	0.8
Arm fat percentage (left)	1.0	3.8	4.2	-2.0	-1.9
Average weekly red wine intake	0.0	0.0	0.0	-0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.2	0.4	0.4
Mood swings	0.1	0.1	0.2	0.5	-0.1
Loneliness, isolation	0.0	0.0	0.0	-0.1	0.2
Long-standing illness, disability or infirmity	0.2	0.3	0.4	-0.6	-0.4
Ever had bowel cancer screening	0.4	0.4	0.6	0.8	0.5
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.7	-0.9	-1.6
Friendships satisfaction	0.1	0.1	0.2	-0.3	-0.4
Qualifications: nursing, teaching	0.1	0.2	0.2	-0.4	-0.4
Commuting to job workplace: Walk	2.0	2.2	3.2	-1.1	-1.8
Eye problems/disorders: Cataract	0.6	0.7	0.9	-0.9	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	2.4	-1.3	-1.5
Medication for cholesterol	0.2	0.4	0.5	0.7	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.6	-0.8	-0.6
Back pain experienced in last month	0.1	0.1	0.2	-0.4	-0.3
Mineral and other dietary supplements	0.1	0.1	0.1	0.4	0.1
Breast cancer (self-reported)	0.9	1.1	1.2	1.0	1.1
Asthma (self-reported)	1.5	3.1	3.2	-1.7	-1.8
Osteoporosis (self-reported)	0.4	0.5	0.5	-0.6	-0.7
Osteoarthritis (self-reported)	0.0	0.0	0.0	-0.2	0.1
Medication: Aspirin	0.1	0.1	0.2	-0.3	-0.4
Medication: Gliclazide	0.0	0.0	0.1	0.2	-0.1
Illnesses of father: None of the above (group 1)	0.4	0.4	0.6	0.5	0.8
Smoking status: Current	0.0	0.0	0.1	-0.3	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.6	0.8	-0.3
Whole body water mass	0.2	1.0	1.2	1.1	0.9
Leg predicted mass (right)	0.2	1.0	1.1	1.1	0.9
Arm fat mass (left)	0.5	2.0	2.0	-1.4	-1.4
Number of self-reported non-cancer illnesses	0.4	0.6	0.7	-0.9	-0.7
Average weekly champagne plus white wine intake	0.0	0.0	0.0	0.2	0.1
Miserableness	0.3	0.5	0.7	0.9	0.4
Guilty feelings	0.6	1.0	1.0	-1.0	-0.9
Wears glasses or contact lenses	0.1	0.1	0.3	0.1	0.5
Ever taken oral contraceptive pill	0.5	0.6	0.6	-0.7	-0.8
Hearing aid user	0.0	0.0	0.0	-0.1	0.2
Mother’s age at death	0.1	0.1	0.2	-0.5	-0.1
Financial situation satisfaction	0.0	0.0	0.0	0.1	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.0	-0.4
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.1	-0.6
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	-0.1	0.2
Medication: Blood pressure	1.6	3.1	4.2	-2.0	-1.4
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.2	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.4	-0.0
High cholesterol (Self-reported)	0.3	0.5	0.7	-0.8	-0.6
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.6	-0.3
Medication: Paracetamol	2.3	3.6	4.0	-1.8	-2.0
Medication: Lisinopril	0.1	0.2	0.3	0.5	0.2
Medication: Atorvastatin	0.4	0.5	1.0	-1.0	-0.3
Illnesses of father: High blood pressure	0.7	0.9	0.9	-0.9	-0.9
Alcohol drinker status: Never	1.0	1.2	1.4	1.1	1.2
Ever smoked	0.4	0.7	1.3	-1.1	-0.3
Basal metabolic rate	0.1	0.3	0.5	0.7	0.4
Leg fat percentage (left)	1.4	5.2	5.4	-2.2	-2.3
Arm fat-free mass (left)	0.2	1.2	1.6	1.3	0.8
Number of operations (self-reported)	0.3	0.5	0.9	-1.0	-0.3
Average weekly beer plus cider intake	1.8	2.6	3.2	1.4	1.8
Irritability	0.7	1.1	1.2	1.0	1.1
Risk taking	2.5	3.7	4.7	-1.7	-2.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	-0.2	-0.7
Fractured/broken bones in last 5 years	1.1	1.4	2.2	1.5	0.8
Age started oral contraceptive pill	0.3	0.3	0.5	0.7	0.4
Diastolic blood pressure, automated reading	0.3	0.9	1.1	0.9	1.1
Ever depressed for a whole week	1.4	1.7	1.9	1.4	1.2
Unable to work because of sickness or disability	1.0	1.2	1.6	1.3	1.0
Commuting to job workplace: Cycle	6.3	7.7	8.2	-2.7	-2.9
Myopia	4.2	6.1	6.8	2.3	2.6
Vascular/heart problems diagnosed by doctor	0.9	2.3	2.7	1.6	1.4
Cholesterol lowering medication	0.2	0.3	0.5	-0.7	0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.4	-0.7	-0.4
Pain experienced in last month	0.0	0.0	0.1	0.1	0.3
Supplements: Calcium	0.0	0.0	0.0	-0.1	-0.2
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.6	0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.1	0.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	1.5	1.2	1.1
Heart disease (siblings)	0.1	0.1	0.2	0.1	0.5
Alcohol drinker status: Previous	3.8	4.3	5.7	1.7	2.4
Pack years of smoking	0.3	0.5	0.7	-0.8	-0.6
Impedance of whole body	1.0	5.2	6.5	-2.5	-2.0
Leg fat mass (left)	0.6	2.3	2.8	-1.4	-1.7
Arm predicted mass (left)	0.2	0.9	1.2	1.1	0.7