Hub : Genes

EFHC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1000 0.0300 4.9e-04 0.047 0.024 0.074 0.065 0.075 2.1e-06 5.1e-04 2.5e-09 2.6e-08 1.9e-09
2 ROSMAP Brain Pre-frontal Cortex 0.1526 0.0346 3.3e-08 0.085 0.056 0.068 0.071 0.091 4.3e-11 1.1e-07 4.7e-09 1.9e-09 9.4e-12
3 YFS Blood 0.0386 0.0124 2.3e-04 0.004 0.014 0.017 0.015 0.010 1.5e-02 1.7e-05 2.2e-06 7.2e-06 2.4e-04
4 TCGA Breast Invasive Carcinoma 0.0166 0.0085 3.3e-03 0.004 0.001 0.001 NA 0.001 4.7e-02 1.6e-01 2.2e-01 NA 1.5e-01
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0462 0.0219 1.3e-03 0.044 0.011 0.005 NA 0.019 9.0e-06 1.8e-02 8.0e-02 NA 2.6e-03
6 TCGA Kidney Renal Papillary Cell Carcinoma 0.1270 0.0740 7.0e-03 0.080 0.029 0.046 NA 0.061 2.5e-05 8.7e-03 1.2e-03 NA 2.1e-04
7 TCGA Brain Lower Grade Glioma 0.0475 0.0285 5.8e-03 0.003 0.018 0.015 NA 0.007 1.3e-01 3.4e-03 7.5e-03 NA 4.9e-02
8 TCGA Lung Adenocarcinoma 0.0473 0.0262 6.6e-03 -0.001 0.007 0.011 NA 0.003 4.3e-01 4.5e-02 1.5e-02 NA 1.4e-01
9 TCGA Thyroid Carcinoma 0.0520 0.0250 6.2e-04 0.028 0.037 0.039 NA 0.037 9.4e-04 1.5e-04 1.0e-04 NA 1.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.9 1.5 2.5 -0.9 1.4 -0.2 -1.2 -1.2 -1.2 -1.5 -1.0 -1.6
Bipolar Disorder or Schizophrenia 0.5 1.3 3.5 -1.0 0.6 0.0 -1.2 -1.1 -1.1 -1.1 -1.1 -1.9
Depressed Affect (Nagel 2018) 0.5 1.1 2.4 0.8 0.4 0.2 1.5 1.1 1.1 1.0 1.6 0.8
Depression (Nagel 2018) 0.4 0.6 1.9 -0.8 0.1 1.3 -0.1 -0.5 -0.5 0.3 -0.6 -1.4
Intelligence (Savage-Jansen 2018) 0.8 2.4 4.3 1.0 -1.6 0.2 1.9 2.1 2.1 1.6 0.8 1.4
Neuroticism (Nagel 2018) 0.1 0.2 0.6 -0.4 0.8 0.7 -0.0 -0.3 -0.3 -0.5 0.0 -0.5
Schizophrenia (2018) 0.2 0.3 1.3 -0.6 -0.4 0.2 -0.6 -0.5 -0.5 -0.1 -0.6 -1.1
Schizophrenia vs Biploar Disorder 0.5 0.6 2.2 -0.7 -1.5 0.2 0.2 0.9 0.9 0.4 0.5 -0.8
Worry (Nagel 2018) 0.2 0.5 2.1 -1.4 0.1 0.5 -0.6 -0.6 -0.6 -0.7 -0.5 -0.5
Alzheimer’s Disease (in mother) 0.4 0.5 1.3 0.0 0.4 -0.5 -0.9 -1.2 -1.2 -0.4 -0.4 0.2
Alzheimer’s Disease (in father) 1.0 1.1 2.7 1.1 -0.9 0.0 1.1 1.1 1.1 0.7 1.0 1.6
Alzheimer’s Disease (including proxy) 0.1 0.2 0.7 0.6 0.1 -0.0 0.2 -0.1 -0.1 0.5 0.1 0.8
Crohns Disease (2017) 0.7 1.6 2.7 -0.0 -0.4 -1.6 1.6 1.5 1.5 1.2 0.4 1.7
Irritable Bowel Disease (IBD) 0.4 0.9 2.3 -0.3 0.3 -0.3 1.5 1.4 1.4 0.8 0.5 0.5
Ulcerative Colitis (UC) 0.4 0.7 1.6 -0.5 1.1 1.3 1.0 0.9 0.9 -0.3 0.3 -0.8
Major Depression (MDD) 0.3 0.4 0.9 -0.6 -0.2 0.5 0.8 1.0 1.0 0.3 0.7 0.0
Reaction Time 1.5 2.8 7.0 -1.9 -0.7 -0.9 -2.0 -1.2 -1.2 -2.1 -2.6 -1.5
Verbal and Numeric Reasoning (VNR) 0.7 1.8 5.6 -0.1 -2.4 -0.5 1.3 1.4 1.4 1.1 -0.2 1.9
Breast Cancer 0.3 0.6 2.0 1.4 0.9 0.1 0.6 0.0 0.0 0.9 0.6 1.0
Ovarian Cancer 0.9 1.2 3.3 -1.1 0.8 1.8 -0.1 -1.3 -1.3 0.0 -1.3 -0.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 4.1 5.9 9.1 -1.8 2.1 1.6 -2.5 -2.9 -2.9 -3.0 -2.3 -2.5
Bipolar Disorder (2011) 4.5 4.3 9.5 -1.4 -0.3 -0.7 -3.1 -2.4 -2.4 -2.0 -2.6 -2.3
Body Mass Index (BMI) (2010) 0.9 1.3 4.7 -0.5 -1.4 -2.2 0.0 0.7 0.7 0.5 -0.4 1.7
Coronary Artery Disease (CAD) 1.0 1.2 2.4 0.2 0.7 0.3 1.5 1.5 1.5 0.8 1.5 0.5
Crohns Disease (2012) 1.2 1.9 3.5 -0.3 -1.5 -1.7 1.3 1.9 1.9 1.2 0.1 1.4
Mean Putamen Volume 0.5 0.6 1.8 -0.9 -1.3 -0.3 -0.3 -0.1 -0.1 -0.8 -1.3 0.4
Fasting Glucose 3.0 3.5 6.6 1.6 -0.0 0.6 2.6 2.5 2.5 2.1 1.9 1.6
HbA1C 0.3 0.3 0.7 -0.0 -0.2 -0.8 -0.8 -0.6 -0.6 -0.4 -0.7 -0.2
HDL Cholesterol 0.2 0.3 1.8 -0.3 0.2 -1.4 -0.0 0.5 0.5 -0.3 0.4 -0.7
LDL Cholesterol 1.0 1.5 6.1 -0.1 -1.6 -2.1 -0.2 -0.0 -0.0 0.5 -0.4 2.5
Lupus 1.0 1.6 5.5 -0.6 -1.6 -2.4 0.8 0.7 0.7 1.1 0.7 1.6
Neuroticism (2016) 1.1 1.6 3.7 -0.2 1.9 -0.3 -1.5 -1.7 -1.7 -1.6 -0.2 -0.6
Primary Biliary Cirrhosis 0.4 0.5 1.0 0.4 -0.9 -0.1 0.7 1.0 1.0 0.4 0.8 0.8
Rheumatoid Arthritis 0.5 0.7 1.6 -0.6 1.3 -0.4 1.0 0.3 0.3 1.2 1.3 0.1
Schizophrenia (2014) 1.2 2.7 7.8 -0.7 1.4 1.5 -1.6 -1.8 -1.8 -1.6 -0.9 -2.8
Triglycerides 0.3 0.5 2.6 0.2 -0.8 -1.6 -0.6 -0.5 -0.5 0.3 -0.5 0.6
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.1 -1.0 -0.0 -0.5 -0.7 -0.7 -0.7 -0.2 -0.3 0.6
Ulcerative Colitis 0.4 0.5 1.8 -1.2 0.4 0.7 -0.2 0.3 0.3 -0.8 -0.2 -1.3
Blood Eosinophil Count 1.1 8.3 18.4 0.5 -2.6 -3.6 1.9 1.9 1.9 3.8 3.3 4.3
Blood Platelet Count 1.9 22.0 57.5 -0.9 -4.2 -7.6 3.8 4.3 4.3 5.3 2.2 6.1
Blood Red Count 0.9 8.6 18.5 -1.6 -0.8 -4.3 -4.3 -3.2 -3.2 -2.9 -2.8 -1.2
Blood White Count 1.1 8.4 28.0 -2.5 -5.3 -3.4 1.7 3.2 3.2 1.8 0.5 1.8
Heel T-Score 0.4 3.0 13.0 -0.3 -2.8 -3.6 -0.2 0.5 0.5 1.7 0.7 1.7
BMI 0.3 1.9 8.5 -0.4 -1.9 -2.9 -0.1 1.4 1.4 1.0 0.0 0.0
Height 0.7 13.0 24.8 1.9 4.9 2.9 -3.2 -5.0 -5.0 -4.1 -1.5 -1.5
Waist Hip Ratio (WHR) 0.1 0.6 2.2 0.7 0.7 0.8 -0.4 -0.1 -0.1 -1.5 -0.8 -0.8
Systolic Blood Pressure 0.4 1.8 6.0 -0.4 1.1 -2.5 -1.6 -1.4 -1.4 -0.9 0.9 0.7
Smoking Status 0.1 0.3 0.6 -0.7 0.5 -0.1 0.1 -0.6 -0.6 0.4 0.4 0.8
Allergy or Eczema 0.2 0.6 2.0 0.5 -1.1 1.4 0.7 0.8 0.8 0.3 0.3 0.1
Cardiovascular Disease 0.6 1.9 9.1 0.4 0.3 -3.0 -1.2 -1.3 -1.3 0.5 0.7 1.6
Hypothyroidism (self reported) 0.3 0.7 2.3 1.5 -0.5 -0.6 0.4 0.5 0.5 0.9 1.1 0.6
Respiratory disease 0.6 1.2 3.0 0.8 -1.2 1.1 1.2 1.7 1.7 -0.1 -0.3 0.5
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.4 -0.1 -1.2 0.8 0.6 0.8 0.8 0.9 0.1 0.1
Lung FEV1/FVC ratio 0.5 2.3 16.3 -4.0 -0.3 -0.7 -1.0 -1.1 -1.1 -0.0 -0.1 -0.8
Lung FVC 0.8 4.1 15.2 -2.3 -3.9 -2.8 -1.6 0.1 0.1 0.6 -2.2 -1.2
Neuroticism 0.3 0.6 2.6 0.3 1.4 1.6 0.2 -0.6 -0.6 0.2 0.2 -0.0
Chronotype (morning person) 0.6 1.3 3.5 -1.0 1.4 0.1 -1.1 -1.9 -1.9 0.3 0.3 -0.7
Hair Pigment 0.1 2.2 4.5 0.3 -0.1 0.2 -1.8 -2.1 -2.1 -2.1 -1.8 -0.4
Tanning 0.1 0.9 3.0 0.6 1.2 -1.3 0.3 0.4 0.4 1.7 1.0 -0.3
Hand grip strength (left) 0.2 0.5 1.9 -0.5 -0.2 -1.4 -0.7 0.2 0.2 -1.3 -0.1 -0.6
Number of treatments/medications taken 0.1 0.2 0.8 -0.0 -0.4 -0.9 0.1 0.5 0.5 -0.4 -0.1 0.6
Average weekly spirits intake 0.5 0.6 1.7 -1.0 -0.8 -0.8 0.1 0.7 0.7 -1.3 -0.5 0.5
Sensitivity / hurt feelings 0.8 1.4 2.8 -0.2 1.6 1.0 -1.2 -1.2 -1.2 -1.3 -0.8 -1.7
Frequency of depressed mood in last 2 weeks 0.8 1.1 2.2 -1.2 1.0 0.2 -0.9 -1.5 -1.5 -0.7 -0.4 -1.0
Hearing difficulty/problems: Yes 0.2 0.3 2.0 -1.4 -0.3 0.2 -0.2 -0.1 -0.1 0.3 -0.3 -0.0
Relative age of first facial hair 0.3 0.6 1.8 1.4 0.2 1.3 0.7 0.7 0.7 -0.1 -0.3 0.2
Other serious medical condition/disability diagnosed by doctor 1.5 2.0 7.6 1.4 1.0 2.8 1.4 0.7 0.7 1.6 1.5 0.1
Ever used hormone-replacement therapy (HRT) 2.2 2.7 7.8 1.2 -2.8 -1.4 1.1 1.9 1.9 1.4 0.8 1.6
Ever had hysterectomy (womb removed) 0.5 0.6 1.3 -0.5 -0.3 -0.9 -1.1 -0.4 -0.4 -0.3 -1.2 -1.1
Systolic blood pressure, automated reading 0.9 2.5 8.4 1.9 0.5 -1.0 1.0 0.9 0.9 1.4 2.9 2.1
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 2.5 -0.5 -1.6 -0.9 -0.9 0.2 0.2 0.2 -0.1 -0.8
Angina 0.7 0.9 5.3 -2.3 0.1 -0.3 -0.2 -0.8 -0.8 0.4 -0.4 -1.1
Medication for hormone replacement therapy 0.3 0.4 2.6 -0.0 -0.4 -0.2 0.1 0.1 0.1 -0.5 0.7 1.6
Vitamin and mineral supplements 2.3 3.1 5.9 2.4 -0.4 -0.1 2.4 2.2 2.2 1.3 1.3 1.9
Supplements: Zinc 0.6 0.6 1.8 -0.8 -0.7 -0.1 -0.9 0.2 0.2 -1.3 -1.0 -0.9
Medication: Co-codamol 0.6 0.6 1.6 0.4 -1.2 -0.1 0.7 1.1 1.1 1.1 -0.5 -0.1
Medication: Metformin 0.5 0.7 3.5 -0.7 -1.9 0.4 0.2 0.9 0.9 -0.0 -0.8 -0.4
Diabetes (father) 0.7 0.8 1.8 0.4 -0.9 -0.2 0.9 1.4 1.4 -0.1 0.6 1.2
Diabetes (mother) 0.6 0.8 2.5 -0.9 -1.6 -1.3 -0.1 0.6 0.6 -0.2 -1.0 0.7
Severe depression (siblings) 1.4 1.6 5.8 -2.4 -0.0 -0.6 -1.1 -0.5 -0.5 -1.6 -1.2 -1.6
Pack years adult smoking proportion 0.4 0.6 2.4 -0.8 -0.1 0.8 -0.3 -0.9 -0.9 1.6 -0.2 -0.5
Impedance of leg (right) 1.8 8.9 19.5 0.7 -2.9 -1.8 3.6 3.0 3.0 3.4 2.3 4.4
Leg fat-free mass (left) 0.7 3.8 7.1 -0.2 1.4 0.6 -2.6 -2.2 -2.2 -2.7 -1.7 -2.4
Trunk fat percentage 0.9 3.5 7.1 0.6 -2.7 -1.8 1.4 2.5 2.5 1.3 0.6 2.1
Hand grip strength (right) 0.4 1.2 3.0 -1.7 -0.6 -1.1 -1.3 -0.8 -0.8 -1.7 -0.6 -0.7
Townsend deprivation index at recruitment 0.8 1.1 2.8 -0.9 0.5 0.7 -1.1 -1.7 -1.7 -0.5 -0.8 -0.8
Current tobacco smoking 0.4 0.7 2.6 -1.6 0.3 -0.2 -0.8 -1.1 -1.1 -0.0 -0.1 -0.7
Average weekly fortified wine intake 1.3 1.5 3.6 -0.4 0.2 -1.6 -1.9 -1.4 -1.4 -1.0 -1.1 -1.2
Maternal smoking around birth 0.2 0.3 0.9 0.9 0.2 -1.0 -0.2 0.3 0.3 -0.3 0.6 -0.6
Fed-up feelings 0.6 1.1 4.6 0.7 2.2 1.4 1.0 -0.0 -0.0 0.6 1.2 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 4.0 -0.9 0.8 2.0 0.6 -0.2 -0.2 0.3 -0.5 -1.0
Relative age voice broke 0.3 0.5 1.8 1.1 0.6 0.7 0.6 0.4 0.4 0.2 1.3 0.2
Taking other prescription medications 0.4 0.6 3.4 0.6 -0.3 1.9 0.5 0.4 0.4 0.6 -0.3 -0.3
Age when periods started (menarche) 0.2 0.5 2.3 -0.1 0.6 0.9 -0.0 -0.1 -0.1 -1.5 -0.2 0.7
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 4.9 0.3 -0.7 -2.2 -0.2 0.2 0.2 0.5 -0.1 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 2.2 0.2 -0.0 -1.5 -0.2 0.1 0.1 0.8 1.3 -0.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.5 -0.7 -0.7 -0.7 0.0 0.5 0.5 -0.3 -0.7 0.4
Qualifications: CSEs or equivalent 0.4 0.5 2.4 -1.5 -0.3 -1.4 -0.1 0.2 0.2 -0.3 -0.4 0.0
Serious illness, injury or assault to yourself 2.2 2.7 6.2 -1.1 0.7 0.6 -2.0 -2.5 -2.5 -1.0 -1.3 -1.7
High blood pressure 0.5 1.3 3.4 1.1 1.1 -1.8 -0.4 -0.9 -0.9 0.5 1.5 1.4
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.7 -0.1 -0.8 0.8 0.1 -0.0 -0.0 -0.4 -0.1 0.2
Multivitamins +/- minerals 3.5 4.4 10.2 -3.2 0.1 -0.2 -2.8 -2.3 -2.3 -1.6 -2.1 -2.0
Stomach or abdominal pain in last month 0.6 0.8 1.8 1.3 -1.3 -0.5 0.5 0.9 0.9 0.3 0.0 1.1
Supplements: Glucosamine 0.1 0.1 0.5 -0.7 0.1 0.3 -0.4 -0.3 -0.3 -0.5 -0.2 0.0
Diverticular disease/diverticulitis (self-reported) 8.4 10.0 20.5 2.6 -2.2 -1.1 3.5 3.6 3.6 4.5 2.1 3.6
Medication: Atenolol 1.5 1.9 3.7 0.1 0.9 -1.4 -1.8 -1.8 -1.8 -1.9 -1.0 0.1
Medication: Levothyroxine sodium 2.1 3.5 6.0 1.6 -1.1 -1.8 1.6 1.8 1.8 2.3 1.8 2.4
Sitting height 0.3 1.8 4.1 -0.9 0.5 -0.2 -1.5 -1.6 -1.6 -2.0 -1.5 -1.4
Chronic bronchitis/emphysema (father) 0.5 0.6 2.5 0.2 -0.6 0.3 -0.8 -0.7 -0.7 -0.9 -1.6 -0.4
High blood pressure (mother) 0.5 0.6 2.4 0.8 0.4 0.2 1.0 0.5 0.5 0.4 1.6 0.9
Body mass index (BMI) 0.3 1.3 3.7 -0.2 -1.9 -1.8 -0.1 1.3 1.3 0.7 -0.1 0.4
Impedance of leg (left) 1.6 7.7 17.4 0.6 -2.6 -2.1 3.2 2.9 2.9 3.0 2.2 4.2
Leg predicted mass (left) 0.7 3.8 7.0 -0.2 1.4 0.5 -2.6 -2.2 -2.2 -2.6 -1.7 -2.4
Trunk fat mass 0.4 1.8 3.6 0.6 -1.9 -1.7 0.6 1.7 1.7 0.6 0.3 1.5
Waist circumference 0.1 0.3 0.8 0.9 -0.6 -0.3 0.1 0.9 0.9 0.1 0.1 0.4
Number of incorrect matches in round 2.9 4.9 11.8 -0.7 3.4 1.5 -2.2 -2.1 -2.1 -2.5 -0.3 -3.1
Past tobacco smoking 0.2 0.3 0.9 0.1 0.8 1.0 -0.3 -0.1 -0.1 -0.1 0.4 -0.9
Alcohol usually taken with meals 0.3 0.4 1.5 1.2 -0.3 0.8 0.4 0.0 0.0 0.8 0.4 0.8
Nervous feelings 0.3 0.5 2.7 -1.6 -1.0 0.4 0.0 0.0 0.0 0.2 -0.9 0.3
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.6 4.3 -2.1 0.4 0.7 -0.9 -1.3 -1.3 -1.0 -1.5 -1.6
Hearing difficulty/problems with background noise 0.2 0.4 1.2 -0.3 -0.5 1.1 0.6 0.2 0.2 1.0 0.0 0.5
Hair/balding pattern: Pattern 2 0.2 0.2 0.7 0.3 0.8 0.4 0.2 -0.4 -0.4 0.3 0.5 0.1
Had menopause 2.5 3.2 5.6 1.4 -0.8 1.4 1.9 2.3 2.3 2.4 1.4 1.4
Had other major operations 0.5 0.6 1.9 -1.3 -0.9 -0.3 -0.4 -0.4 -0.4 -0.4 -1.4 -0.5
Forced vital capacity (FVC) 0.5 1.9 3.2 -1.5 -1.4 -1.0 -1.8 -0.9 -0.9 -1.5 -1.2 -1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.6 2.4 -0.3 -0.2 -1.6 -0.6 -0.4 -0.4 1.0 0.9 0.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.6 0.3 0.2 0.8 1.2 1.1 1.1 1.1 1.3 0.4
Qualifications: None of the above 0.3 0.7 1.7 0.6 -0.9 -0.6 0.4 1.1 1.1 1.3 -0.1 -0.8
Financial difficulties in last 2 years 0.5 0.7 1.5 -0.9 1.2 -0.1 -0.7 -1.1 -1.1 -0.9 0.1 -0.2
Mouth/teeth dental problems 0.1 0.2 0.6 0.3 0.8 0.2 0.2 0.1 0.1 -0.4 0.6 0.2
Heart attack 0.4 0.5 1.2 -0.1 -0.5 0.1 0.8 0.6 0.6 1.0 0.6 1.1
Allergy 0.2 0.4 0.8 -0.9 0.9 -0.7 -0.7 -0.7 -0.7 -0.1 0.2 -0.4
Pain all over the body in last month 0.5 0.5 1.4 -0.8 -1.2 0.5 -0.3 0.6 0.6 -1.0 -0.6 -0.4
Diabetes (self-reported) 0.2 0.3 0.5 -0.4 -0.6 0.7 0.3 0.7 0.7 0.6 0.3 -0.5
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.4 -0.5 -1.0 0.8 1.0 0.8 0.8 -0.0 0.0 1.2
Medication: Ramipril 0.3 0.4 1.9 -1.2 -0.4 -1.4 -0.3 0.0 0.0 0.4 0.2 0.5
Medication: Simvastatin 0.8 1.1 3.2 1.4 0.0 -1.8 0.3 0.0 0.0 1.2 1.2 1.3
Fluid intelligence score 0.5 1.0 2.9 -0.3 -1.2 -0.3 1.3 1.1 1.1 0.7 -0.2 1.7
Illnesses of siblings 0.4 0.6 1.6 0.7 1.0 1.3 0.7 0.1 0.1 -0.5 1.2 0.6
Neuroticism score 0.6 1.3 4.9 -0.3 2.2 2.0 0.1 -0.8 -0.8 -0.6 0.1 -0.9
Weight 0.1 0.3 0.9 0.3 -0.6 -1.0 -0.8 0.0 0.0 -0.6 -0.5 -0.1
Impedance of arm (right) 0.6 2.8 6.0 1.0 -0.8 0.5 2.4 1.9 1.9 1.0 1.7 2.4
Arm fat percentage (right) 0.9 3.7 7.7 0.2 -2.8 -2.2 1.2 2.6 2.6 1.4 0.8 1.9
Trunk fat-free mass 0.6 3.5 5.6 0.5 2.1 0.6 -2.2 -2.4 -2.4 -2.3 -1.3 -1.9
Hip circumference 0.2 0.7 1.7 0.9 -1.0 -0.2 0.6 1.3 1.3 0.8 0.4 0.5
Time employed in main current job 0.1 0.1 0.4 -0.2 0.4 0.3 0.3 0.2 0.2 -0.6 -0.4 0.5
Alcohol intake versus 10 years previously 1.2 1.8 6.3 -0.9 -1.9 -2.5 -0.2 0.7 0.7 2.1 -0.3 0.5
Father’s age at death 1.7 2.3 7.2 -0.0 2.7 2.1 -0.8 -1.9 -1.9 -1.3 -0.2 -0.4
Worrier / anxious feelings 0.6 1.2 4.8 -2.2 0.6 0.6 -0.2 0.1 0.1 -1.5 -1.0 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.2 -0.1 -1.1 0.9 -0.4 -0.1 -0.1 -0.3 -0.6 0.3
Falls in the last year 0.6 0.9 2.5 -0.3 -0.3 0.5 -1.6 -1.2 -1.2 -0.8 -0.6 -0.9
Hair/balding pattern: Pattern 3 0.4 0.7 1.6 0.5 0.1 0.9 1.0 0.9 0.9 0.8 1.3 -0.0
Number of live births 0.4 0.6 1.4 1.2 -0.2 -0.1 0.8 1.0 1.0 0.7 0.7 0.9
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 4.4 -2.1 -1.6 -1.6 -1.2 -0.5 -0.5 -1.0 -0.6 -1.0
Pulse rate 1.8 3.1 6.9 -2.6 -0.2 0.3 -1.9 -1.8 -1.8 -1.7 -2.2 -1.8
Happiness 0.5 0.6 1.5 -0.6 -1.0 -1.2 0.6 0.7 0.7 0.1 -0.7 0.6
Noisy workplace 0.7 0.9 3.3 -0.1 -0.1 0.1 -0.9 -0.2 -0.2 -1.2 -1.8 -1.5
Qualifications: A levels/AS levels or equivalent 0.3 0.8 3.4 0.0 0.3 1.9 -0.3 -0.3 -0.3 -1.1 -0.5 -1.3
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 3.3 -1.1 -1.1 0.3 -0.7 -0.3 -0.3 -1.4 -1.8 -1.8
Mouth/teeth dental problems: Dentures 1.0 1.7 6.1 1.7 -0.0 1.5 1.4 0.8 0.8 2.5 0.8 0.3
Asthma 0.3 0.6 2.6 1.1 0.8 1.6 0.3 0.4 0.4 -0.5 -0.3 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.8 -0.6 0.8 -0.8 0.7 0.6 0.6 -0.9 0.5 -0.4
Medication: Cholesterol lowering 0.4 0.6 1.8 0.2 0.5 -1.3 -0.8 -0.9 -0.9 0.7 0.9 0.5
Depression (self-reported) 0.5 0.6 2.5 -1.6 -0.2 0.3 0.1 0.4 0.4 0.1 -0.2 -1.6
Medication: Lansoprazole 1.6 1.8 5.0 0.9 2.1 2.2 -0.7 -1.3 -1.3 -0.3 -0.4 -1.3
Prospective memory result 0.7 0.8 3.4 0.8 1.3 0.3 -0.5 -0.6 -0.6 -1.9 -0.6 -0.6
Lung cancer (father) 1.0 1.2 2.7 0.8 0.4 0.1 1.2 1.4 1.4 1.4 1.7 0.2
Illnesses of mother 0.5 0.6 1.7 -0.8 -0.8 -0.8 -0.9 -0.6 -0.6 -0.2 -1.3 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.4 10.7 -3.3 -2.0 -1.3 -1.9 -1.1 -1.1 -1.2 -1.9 -1.7
Pulse wave Arterial Stiffness index 0.9 1.0 3.3 1.8 0.0 1.7 1.0 0.4 0.4 1.1 0.4 -0.4
Impedance of arm (left) 0.6 2.6 5.9 0.9 -0.9 0.5 2.4 1.9 1.9 1.1 1.6 2.3
Arm fat mass (right) 0.3 1.2 3.2 0.2 -1.8 -1.7 0.1 1.4 1.4 0.2 -0.0 1.0
Trunk predicted mass 0.7 3.8 6.2 0.5 2.2 0.6 -2.3 -2.5 -2.5 -2.3 -1.3 -2.0
Standing height 0.5 4.9 11.4 1.3 2.8 1.8 -1.7 -2.8 -2.8 -3.4 -1.1 -1.1
Length of working week for main job 0.6 0.7 1.9 1.4 0.8 1.3 -0.5 -0.8 -0.8 -0.6 0.1 0.4
Exposure to tobacco smoke at home 0.5 0.5 1.1 -0.1 0.5 -1.1 1.0 0.2 0.2 0.6 0.8 1.0
Breastfed as a baby 0.6 0.7 1.9 -0.8 -0.7 -0.8 -1.4 -1.0 -1.0 -0.5 -0.7 0.0
Tense / ‘highly strung’ 0.3 0.4 1.2 -0.8 1.1 0.7 0.1 -0.3 -0.3 -0.5 0.8 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 6.0 -2.4 0.3 1.4 0.6 0.6 0.6 -0.3 0.2 -1.1
Hair/balding pattern: Pattern 4 0.3 0.8 1.6 0.1 0.5 -0.2 1.1 1.2 1.2 1.0 1.0 1.0
Birth weight of first child 1.9 3.5 9.6 0.1 0.1 1.9 -1.6 -1.1 -1.1 -2.7 -2.3 -3.1
Peak expiratory flow (PEF) 0.8 1.9 7.3 -1.7 -1.4 -2.7 -0.2 0.0 0.0 -0.0 1.2 1.8
Pulse wave reflection index 0.8 0.9 1.6 0.9 -0.8 0.4 1.1 1.3 1.3 1.1 0.9 -0.6
Ever highly irritable/argumentative for 2 days 0.9 1.1 4.2 0.1 1.8 2.1 0.8 -0.3 -0.3 0.5 1.0 -0.8
Loud music exposure frequency 1.0 1.1 3.2 0.8 0.4 -0.1 1.3 1.0 1.0 0.5 1.4 1.8
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.1 -1.3 0.2 0.1 -0.8 -1.1 -1.1 -1.1 -1.4 -0.5
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 2.4 -1.2 -0.3 -0.3 -1.5 -0.9 -0.9 -1.5 -1.1 -0.6
Blood clot in the leg (DVT) 0.9 1.1 2.2 0.4 -1.1 -1.0 1.2 1.5 1.5 1.2 -0.3 0.7
Medication: Paracetamol 0.6 1.0 3.6 -1.1 -1.9 -0.6 0.0 0.9 0.9 -1.0 -0.9 0.1
Headache pain in last month 0.1 0.1 0.8 -0.3 -0.9 -0.2 0.1 0.1 0.1 -0.4 -0.2 0.5
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 4.7 0.1 -0.6 2.2 1.0 1.1 1.1 -0.6 -0.8 -0.7
Glaucoma (self-reported) 2.8 3.2 7.5 2.0 0.1 -0.1 2.1 1.4 1.4 2.7 2.1 2.2
Gout (self-reported) 1.1 1.6 6.4 0.2 1.9 -0.5 1.1 -0.2 -0.2 2.5 1.5 0.6
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 3.5 1.5 -0.5 -0.6 1.1 1.0 1.0 1.9 1.6 1.2
Medication: Amlodipine 0.2 0.3 1.0 -0.4 0.6 -1.0 -0.1 -0.4 -0.4 0.5 -0.5 -0.4
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.2 -1.1 -1.5 -0.9 -0.8 0.6 0.6 -1.1 -1.2 -0.8
Birth weight 0.5 1.1 3.6 -0.7 1.9 -0.4 -1.0 -1.4 -1.4 -0.4 -0.1 -0.3
Chronic bronchitis/emphysema (mother) 1.0 1.1 4.4 2.1 0.5 0.1 1.1 1.0 1.0 1.2 0.6 0.4
High blood pressure (siblings) 0.9 1.3 2.9 0.0 -1.7 -1.7 0.5 1.1 1.1 1.7 -0.2 0.2
Forced vital capacity (FVC), Best measure 0.8 3.1 5.1 -2.3 -2.2 -1.2 -2.1 -1.1 -1.1 -1.4 -2.1 -1.7
Body fat percentage 1.5 6.0 11.6 0.4 -3.4 -2.6 1.7 3.1 3.1 2.1 1.1 2.6
Leg fat percentage (right) 2.4 8.8 16.0 -0.1 -4.0 -3.6 2.0 3.4 3.4 3.1 1.5 3.4
Arm fat-free mass (right) 0.6 3.0 5.5 0.2 1.6 -0.1 -2.4 -2.2 -2.2 -2.0 -1.3 -1.8
Exposure to tobacco smoke outside home 0.1 0.2 0.6 0.3 0.2 -0.7 -0.0 0.0 0.0 0.6 0.2 0.7
Comparative body size at age 10 1.9 5.3 16.2 -0.9 4.0 0.9 -2.0 -3.1 -3.1 -0.7 -0.2 -2.4
Number of full brothers 3.3 4.1 9.5 -1.5 0.9 -0.0 -2.5 -2.0 -2.0 -2.9 -3.1 -1.4
Worry too long after embarrassment 1.2 2.0 5.4 0.3 2.3 1.1 -1.0 -1.5 -1.5 -2.0 -0.7 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 3.6 -1.2 0.9 1.9 -0.4 -0.8 -0.8 -0.7 0.3 -1.9
Wheeze or whistling in the chest in last year 0.3 0.4 1.1 -0.8 0.1 0.1 -0.9 -0.4 -0.4 -1.1 -0.8 -0.5
Number of children fathered 1.0 1.2 3.9 -0.4 -0.7 -1.1 -1.4 0.0 0.0 -2.0 -1.1 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 4.0 0.1 1.2 -0.1 0.0 -0.4 -0.4 -0.4 2.0 0.3
Age at first live birth 1.7 3.0 10.8 -0.9 1.8 0.6 -1.7 -1.9 -1.9 -3.3 -0.6 -1.1
Pulse wave peak to peak time 0.7 0.8 2.4 -1.5 0.2 -1.6 -0.8 -0.4 -0.4 -1.0 -0.3 0.6
Health satisfaction 0.5 0.7 2.2 -0.5 0.8 1.2 0.5 0.3 0.3 -0.5 -0.9 -1.5
Shortness of breath walking on level ground 3.0 3.5 9.8 -1.4 0.2 0.8 -1.7 -1.6 -1.6 -1.8 -2.8 -3.1
Qualifications: College or University degree 1.3 4.1 8.3 -1.3 1.4 0.9 -2.4 -2.5 -2.5 -2.9 -1.2 -2.2
Eye problems/disorders: None of the above 0.2 0.2 0.6 -0.6 -0.1 0.2 0.8 0.1 0.1 -0.3 -0.7 0.1
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.1 0.3 -1.1 -1.5 -0.4 -0.1 -0.1 0.9 0.7 0.6
Emphysema/chronic bronchitis 1.1 1.3 4.1 2.0 -1.0 0.1 1.1 1.4 1.4 0.1 0.3 1.1
Medication for pain relief, constipation, heartburn 0.6 1.0 2.7 0.9 1.2 1.6 -0.4 -1.3 -1.3 0.8 -0.2 -0.1
Neck or shoulder pain in last month 0.4 0.5 1.4 -0.6 1.2 0.9 -0.2 -0.8 -0.8 -0.7 0.3 -0.5
Medication: Blood pressure 0.7 1.2 6.6 -0.1 0.4 -2.6 -0.8 -0.9 -0.9 0.4 0.7 1.1
Angina (self-reported) 0.7 0.9 5.3 -2.3 0.1 -0.1 -0.3 -0.8 -0.8 0.2 -0.3 -1.2
Migraine (self-reported) 2.7 3.4 7.3 -1.3 -1.2 -1.1 -2.3 -1.6 -1.6 -2.7 -2.7 -1.2
Medication: Ibuprofen 0.3 0.3 1.3 -0.2 0.7 -0.4 0.2 0.2 0.2 -1.1 0.3 -0.8
Medication: Allopurinol 1.5 2.0 7.6 1.3 0.9 -0.1 2.0 0.8 0.8 2.8 1.2 1.0
Medication: Omeprazole 0.6 0.7 2.1 -0.5 0.1 0.7 0.6 0.9 0.9 0.9 0.4 -1.4
Medication: Seretide 50 evohaler 0.0 0.0 0.1 0.1 0.1 -0.0 0.0 -0.1 -0.1 -0.1 -0.2 0.2
Mean time to correctly identify matches 1.0 1.9 6.4 -1.2 -0.4 0.2 -1.6 -1.1 -1.1 -1.6 -2.5 -1.1
Heart disease (mother) 0.9 1.1 3.8 1.1 1.5 1.9 0.6 0.4 0.4 -0.0 1.2 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.1 4.6 -0.4 -0.6 -2.1 -1.6 -0.6 -0.6 -0.6 -1.2 -0.2
Whole body fat mass 0.6 2.6 5.9 0.4 -2.4 -2.0 0.8 2.1 2.1 1.1 0.5 1.6
Leg fat mass (right) 0.8 3.2 7.3 -0.2 -2.6 -2.7 0.7 2.0 2.0 1.5 0.6 1.9
Arm predicted mass (right) 0.5 2.5 4.9 0.4 1.4 -0.2 -2.2 -2.1 -2.1 -1.8 -1.2 -1.6
Pulse rate, automated reading 0.3 1.1 3.3 -1.8 -1.8 -0.6 -0.4 0.0 0.0 -0.5 -1.2 0.8
Alcohol intake frequency. 0.2 0.5 1.5 -0.0 -0.2 -1.2 0.5 0.9 0.9 0.8 0.2 -0.4
Comparative height size at age 10 0.1 0.8 1.6 0.2 0.9 0.4 -0.8 -1.3 -1.3 -1.3 0.2 -0.8
Number of full sisters 0.2 0.3 1.6 -0.2 -0.1 -0.2 -0.2 -0.3 -0.3 1.3 0.6 -0.4
Suffer from ‘nerves’ 0.9 1.3 5.7 -0.2 2.4 1.8 0.3 -0.7 -0.7 -0.1 1.1 -0.9
Overall health rating 0.3 0.7 1.5 -1.1 -1.2 0.2 0.9 1.1 1.1 0.4 -0.5 0.0
Chest pain or discomfort 0.5 0.8 1.8 -1.0 -0.4 0.7 -0.8 -0.7 -0.7 -1.2 -1.3 -0.8
Had major operations 1.3 1.5 4.4 -0.4 0.7 1.6 -1.3 -0.8 -0.8 -2.1 -0.9 -1.5
Age at last live birth 3.4 5.0 11.2 -0.4 2.6 1.6 -2.2 -2.7 -2.7 -3.4 -0.7 -1.9
Family relationship satisfaction 0.7 0.9 2.4 -1.0 0.4 -0.7 -0.8 -1.0 -1.0 -1.1 -1.6 -0.6
Leg pain on walking 0.6 0.8 2.8 -0.9 0.9 1.7 -0.4 -0.5 -0.5 -0.3 -0.3 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.5 0.6 -1.6 0.9 0.7 1.0 1.0 0.2 0.7 1.0
Commuting to job workplace: Car/motor vehicle 2.5 2.8 7.3 1.2 0.1 -0.8 1.8 1.6 1.6 2.1 2.7 1.8
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.5 0.4 0.7 -0.0 0.8 0.8 0.8 1.0 1.2 0.6
Medication: Aspirin 0.7 1.0 2.8 -1.3 0.9 -0.6 -1.1 -0.8 -0.8 -1.7 0.5 -0.7
Supplements: Vitamin C 0.6 0.7 2.0 -1.4 -0.2 -0.3 -0.9 -0.9 -0.9 -0.4 -1.1 -0.7
Knee pain experienced in last month 2.6 4.0 9.3 -2.0 0.9 1.2 -2.0 -2.3 -2.3 -0.8 -2.3 -3.1
Hypertension (Self-reported) 0.5 1.4 3.2 1.1 1.3 -1.8 -0.4 -0.9 -0.9 0.6 1.5 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.0 0.4 -1.0 -0.9 -0.6 0.1 0.1 -0.3 -0.8 -0.3
Illnesses of father: Heart disease 1.6 2.2 4.5 -1.8 0.7 -0.5 -1.8 -1.3 -1.3 -1.2 -1.9 -2.1
Illnesses of siblings: Diabetes 0.7 0.9 4.4 -1.3 -0.4 -2.1 -0.3 0.1 0.1 -0.2 -0.5 1.1
Smoking status: Previous 0.3 0.4 0.9 0.8 -0.0 -0.5 0.9 0.7 0.7 0.4 0.6 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 3.9 0.2 1.6 1.1 -0.9 -1.8 -1.8 -2.0 -0.2 -0.0
Whole body fat-free mass 0.8 4.3 7.2 0.1 1.9 0.5 -2.7 -2.5 -2.5 -2.6 -1.6 -2.3
Leg fat-free mass (right) 0.9 5.0 9.3 -0.3 1.9 0.7 -2.9 -2.4 -2.4 -3.0 -1.8 -2.8
Arm fat percentage (left) 0.9 3.6 7.3 0.0 -2.7 -2.1 1.2 2.6 2.6 1.5 0.8 1.8
Average weekly red wine intake 0.5 0.8 2.2 1.5 1.5 1.1 -0.1 -0.7 -0.7 0.3 0.8 0.1
Handedness (chirality/laterality): Left-handed 3.3 4.0 8.3 -0.9 2.0 2.5 -1.6 -1.6 -1.6 -2.9 -1.8 -2.3
Mood swings 1.4 2.6 6.1 1.4 0.9 0.6 2.5 1.8 1.8 0.9 2.5 1.0
Loneliness, isolation 0.2 0.3 1.3 -1.1 -0.6 0.8 -0.3 -0.3 -0.3 -0.2 -0.5 0.2
Long-standing illness, disability or infirmity 0.6 0.8 1.9 0.2 -0.6 1.4 1.0 1.2 1.2 1.1 0.4 -0.2
Ever had bowel cancer screening 0.4 0.5 1.5 0.0 1.2 -0.2 0.6 0.3 0.3 0.7 1.2 0.5
Diabetes diagnosed by doctor 0.2 0.4 1.8 -0.4 -0.3 1.3 0.4 0.5 0.5 0.6 0.3 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 1.0 0.7 0.0 1.0 0.3 -0.1 -0.1 0.2 0.2 0.4
Friendships satisfaction 0.6 0.7 1.5 -0.6 0.1 -0.9 -1.2 -0.8 -0.8 -0.6 -1.0 -1.1
Qualifications: nursing, teaching 1.5 2.4 5.6 1.7 0.2 2.4 1.7 1.9 1.9 0.6 1.6 0.5
Commuting to job workplace: Walk 1.1 1.2 6.0 -2.4 -0.2 -0.5 -0.8 -0.9 -0.9 -0.8 -1.1 -0.7
Eye problems/disorders: Cataract 0.8 0.9 2.2 0.1 0.7 0.4 -1.5 -1.4 -1.4 -0.3 0.3 -1.0
Mouth/teeth dental problems: Mouth ulcers 1.5 2.3 6.1 -1.8 -0.2 -0.6 -1.8 -1.0 -1.0 -2.5 -1.9 -1.4
Medication for cholesterol 0.8 1.2 2.1 1.1 -0.5 -0.0 1.3 1.5 1.5 1.5 1.0 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 3.5 0.5 -1.0 -1.0 1.3 1.0 1.0 1.8 1.9 1.3
Back pain experienced in last month 0.7 1.0 5.7 -0.8 0.1 1.4 -0.6 -0.2 -0.2 -0.1 -0.5 -2.4
Mineral and other dietary supplements 1.0 1.4 4.1 2.0 -0.1 -0.9 1.5 1.1 1.1 1.2 0.9 0.8
Breast cancer (self-reported) 0.5 0.6 1.0 -0.5 0.9 -0.0 -0.9 -1.0 -1.0 -0.8 -0.7 0.1
Asthma (self-reported) 0.4 0.7 3.3 1.2 0.9 1.8 0.2 0.3 0.3 -0.6 -0.3 -0.6
Osteoporosis (self-reported) 1.0 1.2 4.2 1.6 -0.3 0.3 1.0 0.4 0.4 1.2 1.0 2.1
Osteoarthritis (self-reported) 0.9 1.1 5.9 0.6 1.4 2.4 0.2 -0.4 -0.4 0.9 0.7 -0.1
Medication: Aspirin 0.6 0.7 1.8 -1.1 0.8 -0.8 -1.0 -0.6 -0.6 -1.4 0.6 -0.3
Medication: Gliclazide 0.6 0.6 2.6 -0.9 -1.6 -0.5 0.3 0.7 0.7 0.4 -0.9 -0.2
Illnesses of father: None of the above (group 1) 2.2 2.7 6.4 1.5 -0.1 1.2 2.1 1.2 1.2 2.5 1.8 1.9
Smoking status: Current 0.5 0.8 2.7 -1.6 0.2 -0.3 -0.9 -1.3 -1.3 -0.1 -0.3 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.8 3.8 13.9 -1.8 -3.7 -2.5 0.8 2.0 2.0 1.6 -0.5 0.6
Whole body water mass 0.7 4.0 6.6 0.3 1.9 0.5 -2.6 -2.4 -2.4 -2.5 -1.6 -2.3
Leg predicted mass (right) 0.9 5.0 9.5 -0.2 1.9 0.7 -2.8 -2.4 -2.4 -3.1 -1.8 -2.9
Arm fat mass (left) 0.4 1.6 3.4 0.4 -1.8 -1.6 0.5 1.7 1.7 0.7 0.3 1.2
Number of self-reported non-cancer illnesses 0.1 0.2 1.0 0.6 1.0 0.3 0.5 -0.1 -0.1 0.2 0.4 0.5
Average weekly champagne plus white wine intake 0.8 1.1 1.8 -0.9 1.3 0.5 -0.4 -1.1 -1.1 -1.1 -1.1 -1.4
Miserableness 0.3 0.6 3.1 -1.8 -0.1 -0.1 1.0 0.6 0.6 0.3 -0.2 0.1
Guilty feelings 1.6 2.4 5.2 -0.9 2.3 1.3 -1.5 -1.9 -1.9 -1.1 0.2 -2.0
Wears glasses or contact lenses 1.1 1.3 2.7 1.3 1.3 1.5 1.3 0.7 0.7 0.8 1.6 -0.0
Ever taken oral contraceptive pill 1.1 1.3 7.1 0.6 1.4 0.2 0.7 0.1 0.1 0.6 2.7 1.1
Hearing aid user 1.5 1.7 6.5 0.3 -2.5 -1.6 0.0 0.9 0.9 1.9 -0.6 0.3
Mother’s age at death 1.1 1.4 3.8 -0.3 -1.5 -1.9 -0.3 0.5 0.5 -1.9 -1.1 1.1
Financial situation satisfaction 0.4 0.5 1.8 -0.2 -0.3 -0.4 1.1 0.6 0.6 0.0 -0.1 1.4
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.5 1.2 0.1 -0.6 1.1 1.1 1.1 1.2 1.9 1.2
Commuting to job workplace: Public transport 3.2 3.9 9.0 -1.6 -0.6 -1.0 -2.4 -2.1 -2.1 -2.0 -3.0 -1.8
Eye problems/disorders: Glaucoma 4.1 4.9 9.4 2.1 0.1 -1.2 2.3 1.9 1.9 3.1 2.9 2.8
Medication: Blood pressure 0.2 0.4 1.0 -0.3 -0.4 -0.7 -0.7 -1.0 -1.0 0.4 -0.7 0.0
Pain type(s) experienced in last month: Hip pain 0.7 0.8 4.7 1.2 0.4 -0.1 0.7 0.1 0.1 2.2 0.6 0.6
Supplements: Fish oil (including cod liver oil) 1.5 2.0 4.1 -1.7 0.9 0.7 -1.7 -1.6 -1.6 -2.0 -0.9 -0.9
High cholesterol (Self-reported) 0.9 1.5 6.1 0.3 -1.7 -2.5 -0.9 -0.6 -0.6 1.2 -0.8 1.1
Medication: Bendroflumethiazide 0.4 0.6 1.7 -0.8 0.1 -0.9 -1.0 -0.8 -0.8 -0.4 -1.3 -0.6
Medication: Paracetamol 0.8 1.2 3.3 -1.3 -1.4 -0.6 -1.0 -0.1 -0.1 -1.8 -1.5 -0.3
Medication: Lisinopril 1.2 1.6 8.9 -1.7 -1.2 -3.0 -0.2 0.3 0.3 -0.0 -0.9 0.4
Medication: Atorvastatin 0.3 0.3 2.3 -1.5 -0.1 -0.1 -0.5 -0.4 -0.4 0.2 -0.1 0.3
Illnesses of father: High blood pressure 1.0 1.2 2.8 -1.7 -0.0 -1.7 -1.0 -0.4 -0.4 -1.5 -0.7 -1.1
Alcohol drinker status: Never 0.2 0.3 0.6 -0.3 0.1 -0.6 -0.7 -0.3 -0.3 -0.8 -0.6 -0.4
Ever smoked 0.5 0.9 2.7 -1.2 -1.1 -1.6 -0.6 -0.6 -0.6 -0.4 -1.1 0.4
Basal metabolic rate 0.5 2.5 4.8 0.2 1.2 0.0 -2.2 -1.8 -1.8 -2.1 -1.4 -1.7
Leg fat percentage (left) 2.3 8.1 15.3 -0.3 -3.9 -3.8 1.7 3.3 3.3 2.8 1.3 3.1
Arm fat-free mass (left) 0.4 2.3 4.6 0.4 1.2 -0.3 -2.1 -1.8 -1.8 -1.9 -1.2 -1.6
Number of operations (self-reported) 0.5 0.7 3.0 -0.4 -0.3 1.2 -0.5 -0.4 -0.4 -0.9 -1.7 -0.5
Average weekly beer plus cider intake 1.5 2.1 8.8 -0.0 -3.0 -1.8 0.8 1.4 1.4 1.0 0.3 1.2
Irritability 0.6 1.0 3.5 -0.7 1.1 1.6 -0.0 -0.5 -0.5 -0.6 -0.7 -1.9
Risk taking 0.6 0.9 2.6 -0.3 -0.2 0.9 -1.1 -0.5 -0.5 -1.3 -0.9 -1.6
Ever had prostate specific antigen (PSA) test 0.9 1.1 3.3 -1.8 0.0 -0.4 -0.9 -0.7 -0.7 -0.3 -1.5 -1.5
Fractured/broken bones in last 5 years 0.7 0.9 5.2 0.6 1.3 2.3 0.4 0.2 0.2 -0.3 0.8 -0.5
Age started oral contraceptive pill 1.8 2.2 5.4 -0.8 -0.3 -0.4 -2.3 -1.5 -1.5 -2.2 -1.8 -0.9
Diastolic blood pressure, automated reading 0.5 1.5 5.0 0.5 0.2 -2.2 -0.3 -0.3 -0.3 0.2 1.8 2.2
Ever depressed for a whole week 0.3 0.4 1.4 -1.2 -0.1 -0.8 0.2 0.2 0.2 0.4 0.9 0.6
Unable to work because of sickness or disability 0.4 0.5 2.0 -0.9 -0.2 1.4 0.2 0.4 0.4 0.8 -0.1 -0.6
Commuting to job workplace: Cycle 2.2 2.7 5.5 -1.1 1.5 1.2 -1.0 -2.4 -2.4 -1.6 -1.7 -1.3
Myopia 0.2 0.3 1.0 -0.9 -0.3 -1.0 0.1 -0.1 -0.1 0.2 -0.4 -0.3
Vascular/heart problems diagnosed by doctor 0.4 1.2 3.0 -0.2 -1.0 1.7 1.0 1.5 1.5 -0.2 -0.4 -0.9
Cholesterol lowering medication 0.7 1.0 2.2 -0.0 -1.1 -1.5 0.7 0.7 0.7 1.3 0.3 1.5
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.9 0.1 0.1 1.7 0.6 0.9 0.9 0.1 -0.1 -2.0
Pain experienced in last month 0.5 0.9 1.6 1.2 -0.1 -0.6 1.0 0.9 0.9 1.1 0.8 1.2
Supplements: Calcium 1.1 1.2 2.4 -0.8 0.3 1.1 -1.3 -1.1 -1.1 -1.6 -0.7 -1.3
Basal cell carcinoma (self-reported) 3.4 4.0 11.8 1.6 -0.1 -1.4 2.0 1.3 1.3 3.4 2.4 2.5
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.3 -0.3 -0.6 -0.3 0.6 0.5 0.5 1.0 0.6 1.1
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.1 0.3 -1.2 -1.1 0.9 1.4 1.4 1.0 -0.3 0.6
Heart disease (siblings) 1.4 1.7 5.4 -1.8 -1.8 -1.3 -1.0 -0.1 -0.1 -0.2 -2.3 -0.9
Alcohol drinker status: Previous 0.5 0.6 1.1 0.8 1.1 0.8 0.9 0.8 0.8 -0.1 0.0 -0.7
Pack years of smoking 0.5 0.7 2.4 -1.1 -0.3 0.8 -0.3 -0.9 -0.9 1.5 -0.5 -0.5
Impedance of whole body 0.9 4.4 10.7 0.8 -1.7 -0.8 2.7 2.2 2.2 2.0 2.0 3.3
Leg fat mass (left) 0.7 2.8 7.2 -0.2 -2.5 -2.7 0.6 1.8 1.8 1.3 0.4 1.7
Arm predicted mass (left) 0.4 2.1 5.0 0.2 0.9 -0.6 -2.2 -1.8 -1.8 -1.7 -1.2 -1.5