Hub : Genes

EGFR

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1010	0.0330	3.4e-04	0.003	0.041	0.044	0.042	0.026	1.1e-01	7.9e-06	3.6e-06	6.1e-06	3.8e-04
2	GTEx	Artery Aorta	0.1700	0.0680	9.9e-03	0.000	NA	-0.005	NA	0.003	3.2e-01	NA	7.9e-01	NA	2.0e-01
3	GTEx	Muscle Skeletal	0.0864	0.0328	3.4e-03	-0.003	NA	0.000	NA	-0.002	8.5e-01	NA	3.0e-01	NA	6.3e-01
4	GTEx	Nerve Tibial	0.1829	0.0487	3.0e-05	0.040	NA	0.079	NA	0.099	7.5e-04	NA	3.1e-06	NA	1.8e-07
5	ROSMAP	Brain Pre-frontal Cortex	0.1581	0.0358	1.6e-08	0.034	0.076	0.086	0.078	0.058	3.2e-05	5.2e-10	3.2e-11	3.2e-10	5.9e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.2	0.8	0.2	-0.9	-0.2	-0.3	0.2
Bipolar Disorder or Schizophrenia	0.4	1.0	3.7	0.2	-1.9	-0.6	-0.8	0.3
Depressed Affect (Nagel 2018)	1.1	2.3	6.7	0.8	0.7	2.6	-0.7	1.8
Depression (Nagel 2018)	0.7	1.0	3.3	0.5	0.0	1.8	-1.2	0.6
Intelligence (Savage-Jansen 2018)	1.3	3.9	12.0	-3.5	0.6	-0.3	2.3	-1.4
Neuroticism (Nagel 2018)	1.2	2.7	7.8	1.7	0.2	2.8	-0.4	1.7
Schizophrenia (2018)	0.4	0.8	3.0	0.0	-1.7	-0.5	-0.8	0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	-0.2	0.2	-0.2	-0.7	-0.1
Worry (Nagel 2018)	1.8	3.7	11.1	3.3	-0.0	1.8	-0.9	1.9
Alzheimer’s Disease (in mother)	2.2	2.6	8.5	2.9	0.3	0.6	1.0	1.7
Alzheimer’s Disease (in father)	2.1	2.2	6.4	2.5	1.1	1.0	-0.2	1.6
Alzheimer’s Disease (including proxy)	3.9	5.7	20.8	4.6	0.9	0.3	0.7	2.5
Crohns Disease (2017)	0.4	1.0	2.4	0.9	1.1	-1.6	-0.2	0.5
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	0.7	0.2	-1.1	-0.5	0.4
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.0	-0.6	-0.2	-0.6	0.4
Major Depression (MDD)	2.2	2.7	6.4	-0.5	-2.2	2.5	-0.6	-1.3
Reaction Time	2.6	5.0	9.9	3.1	0.3	-0.2	-2.8	2.6
Verbal and Numeric Reasoning (VNR)	1.2	2.9	7.4	-2.7	0.1	1.5	2.3	-0.1
Breast Cancer	0.3	0.8	2.7	-0.4	-0.0	-1.6	-0.5	0.9
Ovarian Cancer	0.4	0.6	1.9	-0.2	0.7	0.5	1.4	0.3
Prostate Cancer	1.7	2.3	4.4	-1.8	-1.4	0.5	-1.4	-2.1
Age at First Birth	0.9	1.3	4.5	-1.1	0.4	0.8	-2.1	0.1
Bipolar Disorder (2011)	2.5	2.5	11.9	-0.3	-3.5	-0.2	0.3	-0.4
Body Mass Index (BMI) (2010)	0.5	0.7	3.3	-0.1	-0.1	-0.2	1.8	-0.3
Coronary Artery Disease (CAD)	0.7	0.9	2.6	0.2	0.7	-1.6	-1.0	-0.0
Crohns Disease (2012)	0.6	1.0	3.0	1.7	0.6	-1.2	0.1	0.4
Mean Putamen Volume	3.2	3.6	7.5	-1.9	2.4	2.7	0.6	-1.0
Fasting Glucose	0.6	0.7	1.1	0.9	-0.1	-1.0	-1.0	1.1
HbA1C	0.9	1.0	2.9	-0.6	0.2	0.5	-1.7	-1.1
HDL Cholesterol	0.3	0.4	1.3	-0.1	1.2	-0.7	-0.6	-0.2
LDL Cholesterol	1.4	2.2	4.7	-0.9	-1.9	-2.2	0.1	1.4
Lupus	0.3	0.4	0.9	0.1	0.4	0.9	-0.9	0.3
Neuroticism (2016)	0.3	0.4	0.7	0.0	0.3	0.9	-0.7	0.8
Primary Biliary Cirrhosis	0.9	1.2	2.4	1.6	-0.2	-1.3	-0.9	1.1
Rheumatoid Arthritis	0.7	0.9	2.6	-0.0	-0.1	-1.0	-1.6	1.0
Schizophrenia (2014)	0.5	1.1	3.6	-0.2	-1.9	-0.9	-1.1	0.0
Triglycerides	1.4	2.2	5.3	1.4	-0.5	-1.9	-0.5	2.3
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.9	-0.0	-1.7	-1.1	-0.5	-0.1
Ulcerative Colitis	0.9	1.3	2.1	0.7	-1.0	-1.2	-1.1	1.4
Blood Eosinophil Count	0.1	1.0	4.0	-0.8	-0.2	2.0	0.3	0.5
Blood Platelet Count	0.2	2.8	11.8	-0.5	0.6	1.2	-3.4	0.4
Blood Red Count	0.1	1.1	2.7	0.7	1.4	0.3	1.6	-0.4
Blood White Count	0.4	2.9	5.0	1.4	1.4	2.0	-2.2	1.1
Heel T-Score	1.3	10.7	30.0	1.8	2.6	-5.5	-2.4	2.8
BMI	0.5	2.7	7.2	-1.0	-1.4	2.7	0.1	-1.8
Height	0.1	1.3	2.6	-0.8	0.7	1.4	-1.6	0.8
Waist Hip Ratio (WHR)	0.1	0.6	1.4	1.2	-0.9	0.4	-0.7	0.3
Systolic Blood Pressure	0.4	1.8	6.6	1.1	-0.4	-2.6	0.8	0.8
Smoking Status	0.4	1.0	1.8	-1.4	-1.2	1.1	-0.6	-0.4
Allergy or Eczema	0.4	1.1	2.7	-0.1	-1.5	1.7	-0.2	0.4
Cardiovascular Disease	0.4	1.3	2.0	-0.4	-0.9	1.4	-1.3	1.3
Hypothyroidism (self reported)	0.4	0.9	2.2	-1.5	0.3	1.4	0.2	-0.7
Respiratory disease	0.4	1.0	1.9	-0.5	-0.8	0.5	-1.4	-1.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.2	-0.9	-0.5	-0.7	-1.1	0.5
Lung FEV1/FVC ratio	0.4	2.0	4.5	0.7	1.8	-0.2	-2.1	-1.4
Lung FVC	0.1	0.4	0.9	-0.5	-0.7	0.4	0.4	-0.9
Neuroticism	1.4	3.4	7.6	2.3	0.5	2.8	-0.3	2.0
Chronotype (morning person)	1.3	2.9	9.8	-2.0	-0.5	0.7	-0.5	-3.1
Hair Pigment	0.1	2.1	6.7	0.5	-0.2	1.9	2.6	-0.1
Tanning	0.2	2.2	4.1	-1.9	-0.0	1.2	1.5	-2.0
Hand grip strength (left)	0.4	1.1	5.2	-0.3	0.2	-2.3	-0.3	-0.2
Number of treatments/medications taken	0.7	1.3	3.0	0.5	-0.2	1.4	-1.7	1.0
Average weekly spirits intake	0.1	0.1	0.2	0.4	-0.2	0.5	-0.3	-0.1
Sensitivity / hurt feelings	0.1	0.2	0.7	0.3	-0.6	0.8	-0.1	-0.1
Frequency of depressed mood in last 2 weeks	0.7	0.9	3.4	0.5	0.4	1.9	-0.5	0.7
Hearing difficulty/problems: Yes	0.6	0.9	2.2	1.5	-0.8	0.3	-0.2	1.4
Relative age of first facial hair	0.5	1.0	2.3	-1.2	-0.6	0.7	0.8	-1.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	-1.1	-0.4	0.8	0.5	-0.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.4	0.1	-1.8	0.8	-0.4	0.1
Ever had hysterectomy (womb removed)	0.6	0.7	2.6	0.4	0.5	1.6	0.4	-0.3
Systolic blood pressure, automated reading	0.7	2.1	6.0	2.0	0.6	-2.5	-0.3	0.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.0	4.3	0.2	0.1	-0.2	-2.1	0.9
Angina	0.6	0.8	1.3	-0.5	1.1	0.6	-1.0	1.0
Medication for hormone replacement therapy	0.8	0.9	2.8	-0.7	-1.7	-0.3	0.6	-0.9
Vitamin and mineral supplements	0.5	0.7	2.2	0.5	1.0	-1.5	-0.4	0.1
Supplements: Zinc	1.1	1.2	4.2	0.6	-2.1	1.1	0.2	0.1
Medication: Co-codamol	0.8	0.9	2.0	-1.2	-0.3	0.9	1.4	-0.7
Medication: Metformin	0.3	0.5	1.1	-0.8	-0.1	-0.6	-1.1	0.4
Diabetes (father)	0.4	0.5	0.9	-0.8	-1.0	-0.1	-0.5	0.8
Diabetes (mother)	1.0	1.2	3.0	0.2	-1.7	1.5	-0.7	-0.3
Severe depression (siblings)	0.6	0.6	1.9	0.8	1.4	0.5	0.2	0.5
Pack years adult smoking proportion	2.1	3.2	8.9	2.6	-0.1	0.3	-0.6	3.0
Impedance of leg (right)	0.2	1.2	4.0	1.2	0.6	-2.0	0.1	0.2
Leg fat-free mass (left)	0.3	1.8	5.2	-1.3	-0.9	2.3	0.0	-1.2
Trunk fat percentage	0.5	1.9	6.2	0.7	0.2	2.5	0.7	-1.5
Hand grip strength (right)	0.1	0.4	1.0	0.3	0.3	-1.0	-0.6	0.7
Townsend deprivation index at recruitment	1.3	1.8	3.0	0.1	-1.7	1.6	1.7	-0.5
Current tobacco smoking	0.5	0.9	2.5	0.8	-1.6	0.2	-0.3	1.1
Average weekly fortified wine intake	0.6	0.7	1.4	0.4	0.4	-0.8	-1.0	1.2
Maternal smoking around birth	1.0	1.5	6.2	0.1	-2.5	-0.5	-0.9	0.6
Fed-up feelings	1.2	2.2	4.2	1.1	0.6	1.8	-2.1	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.5	0.8	-0.5	1.1	-1.2	1.2
Relative age voice broke	1.0	1.5	3.0	-1.7	0.4	1.1	0.6	-1.7
Taking other prescription medications	0.4	0.6	2.4	0.3	-0.3	-0.4	-1.5	0.6
Age when periods started (menarche)	0.6	1.5	3.0	1.7	-0.1	-0.7	-1.5	1.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.2	1.1	-0.6	0.5	0.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	9.4	-0.9	-1.2	-3.1	-0.4	-0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	0.6	-0.6	0.5	-0.5	-1.0
Qualifications: CSEs or equivalent	0.6	0.8	2.7	0.3	-0.1	1.6	-0.2	1.0
Serious illness, injury or assault to yourself	0.3	0.3	1.2	-0.1	0.1	1.1	-0.1	0.6
High blood pressure	0.3	0.9	2.5	0.6	-0.9	0.6	-1.6	0.9
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.5	-0.7	-1.5	1.6	-0.5	0.3
Multivitamins +/- minerals	0.5	0.6	2.8	-0.3	-1.7	0.3	0.0	0.2
Stomach or abdominal pain in last month	0.2	0.3	0.9	-0.9	0.1	0.0	-0.5	-0.6
Supplements: Glucosamine	0.2	0.3	1.3	-0.1	-1.2	0.4	-0.2	0.2
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	6.0	-0.5	0.4	-2.4	-0.9	0.1
Medication: Atenolol	1.5	1.9	3.9	1.2	0.5	-0.4	-1.9	2.0
Medication: Levothyroxine sodium	1.4	2.4	5.2	-1.5	1.9	2.3	-0.4	-0.6
Sitting height	0.2	1.6	4.3	-2.1	-1.3	-1.1	-0.7	0.4
Chronic bronchitis/emphysema (father)	1.1	1.3	5.6	0.5	2.4	0.6	-0.0	-0.0
High blood pressure (mother)	0.4	0.6	1.3	0.3	0.6	1.1	1.1	0.1
Body mass index (BMI)	0.3	1.2	3.1	0.1	-0.3	1.8	-0.3	-1.6
Impedance of leg (left)	0.3	1.4	4.5	1.4	0.3	-2.1	0.4	0.4
Leg predicted mass (left)	0.3	1.8	5.0	-1.3	-0.9	2.2	0.1	-1.2
Trunk fat mass	0.3	1.4	4.8	0.2	-0.3	2.2	0.3	-1.5
Waist circumference	0.3	1.0	1.5	0.2	-1.1	1.2	-1.2	-0.9
Number of incorrect matches in round	0.3	0.5	1.1	0.9	-0.5	-0.1	-1.1	0.6
Past tobacco smoking	2.5	4.6	9.4	3.1	0.4	-2.4	-0.1	2.8
Alcohol usually taken with meals	0.4	0.6	2.3	-1.5	0.3	0.2	-0.3	-0.7
Nervous feelings	0.9	1.7	4.0	2.0	-0.6	1.7	-0.4	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.4	0.3	0.7	1.5	1.3	0.3
Hearing difficulty/problems with background noise	1.1	1.7	5.0	2.2	0.0	-1.3	0.5	1.3
Hair/balding pattern: Pattern 2	2.1	2.7	7.2	0.7	-2.3	2.7	-0.1	0.2
Had menopause	0.5	0.7	1.3	0.4	-1.1	-0.7	-1.1	-0.3
Had other major operations	0.2	0.2	0.5	0.5	0.3	-0.7	-0.1	0.7
Forced vital capacity (FVC)	0.4	1.4	2.2	-1.3	-1.2	0.3	1.5	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	5.7	-0.2	-1.0	-2.4	-0.5	0.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	0.8	-0.5	0.8	0.3	1.1
Qualifications: None of the above	0.2	0.5	1.7	1.3	-0.6	0.0	0.1	-0.6
Financial difficulties in last 2 years	0.7	1.0	3.3	1.0	-0.8	-0.2	-0.1	1.8
Mouth/teeth dental problems	0.5	0.8	1.9	-0.2	-0.4	1.3	0.1	-1.4
Heart attack	0.6	0.8	1.2	1.1	-0.7	-1.1	-0.6	0.8
Allergy	0.4	1.0	1.8	0.9	1.2	-1.3	0.8	-0.0
Pain all over the body in last month	0.2	0.3	0.5	0.7	0.6	-0.1	-0.6	-0.3
Diabetes (self-reported)	0.7	1.1	3.8	-0.6	-1.2	0.0	-2.0	0.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	4.9	-0.8	-0.1	2.2	0.5	-1.1
Medication: Ramipril	3.3	4.2	9.4	1.0	-2.0	-0.4	-3.1	2.5
Medication: Simvastatin	0.8	1.1	2.3	0.6	-0.5	0.8	-1.4	1.5
Fluid intelligence score	1.4	2.9	11.8	-1.4	0.6	0.7	3.4	-0.3
Illnesses of siblings	1.3	1.8	5.2	2.3	0.9	-0.2	-0.9	1.4
Neuroticism score	1.6	3.4	13.2	1.3	0.2	3.6	0.5	1.2
Weight	0.3	1.4	3.7	-0.6	-0.6	1.9	-0.4	-1.5
Impedance of arm (right)	0.2	1.1	3.4	0.9	0.4	0.5	1.8	1.0
Arm fat percentage (right)	0.3	1.4	4.8	0.7	0.2	2.2	0.5	-1.1
Trunk fat-free mass	0.3	1.4	3.0	-1.7	-1.4	-0.1	-1.5	-0.2
Hip circumference	0.4	1.5	3.8	-1.1	-0.3	1.6	-0.3	-1.9
Time employed in main current job	0.6	0.7	1.3	0.7	0.8	1.2	1.0	-0.3
Alcohol intake versus 10 years previously	0.2	0.4	0.8	0.7	0.9	-0.6	0.2	0.1
Father’s age at death	1.1	1.4	2.7	-1.6	1.0	1.4	0.4	-1.1
Worrier / anxious feelings	1.2	2.2	8.3	0.7	0.3	2.9	0.0	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	7.0	1.6	0.9	1.9	-0.7	2.6
Falls in the last year	0.7	0.9	2.3	-1.1	1.5	0.1	0.7	-0.6
Hair/balding pattern: Pattern 3	1.5	2.2	5.0	-0.3	2.2	-2.1	1.2	-0.0
Number of live births	0.8	1.1	2.0	1.1	1.4	-1.3	-0.0	0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.2	-1.2	-0.9	0.4	1.0	-1.5
Pulse rate	0.5	0.8	1.7	1.3	-1.2	-0.8	-0.3	0.4
Happiness	2.7	3.3	7.8	2.7	1.1	0.3	-0.1	2.8
Noisy workplace	0.7	0.9	3.1	0.5	0.2	1.8	-0.6	0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.3	-1.5	1.2	0.7	-0.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.4	-1.9	1.1	1.7	0.2	0.1
Mouth/teeth dental problems: Dentures	1.1	1.8	3.9	1.4	0.6	-2.0	-0.5	1.6
Asthma	0.4	0.8	1.7	-0.9	-0.1	0.8	-0.8	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	0.8	1.3	1.2	0.7	0.5
Medication: Cholesterol lowering	0.8	1.2	3.3	-0.2	-1.5	0.1	-1.8	0.7
Depression (self-reported)	1.6	1.9	7.4	0.2	-2.7	0.4	-1.0	0.9
Medication: Lansoprazole	0.4	0.4	1.1	0.6	-0.2	-0.9	-1.0	0.3
Prospective memory result	0.7	0.9	2.9	0.4	-1.1	-1.7	0.2	-0.5
Lung cancer (father)	0.6	0.6	2.8	-0.2	0.3	-1.7	-0.2	-0.5
Illnesses of mother	0.4	0.4	1.2	-0.2	0.6	-1.1	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.2	-1.1	-0.4	0.0	0.2	-0.7
Pulse wave Arterial Stiffness index	2.6	3.1	8.7	-1.3	-0.1	1.0	2.0	-3.0
Impedance of arm (left)	0.2	0.9	1.6	0.6	0.9	1.1	1.3	0.8
Arm fat mass (right)	0.3	1.2	4.2	0.2	0.1	2.0	0.2	-1.3
Trunk predicted mass	0.2	1.3	2.5	-1.6	-1.4	-0.1	-1.4	-0.2
Standing height	0.1	0.9	3.3	-1.8	-0.8	0.7	0.0	-0.2
Length of working week for main job	1.1	1.2	2.8	-0.5	-0.6	-1.7	-1.6	0.5
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.3	0.2	0.2	0.8	-0.0
Breastfed as a baby	1.8	2.2	6.5	-2.5	-0.4	0.6	1.7	-1.2
Tense / ‘highly strung’	0.9	1.5	3.6	1.2	-0.5	1.5	1.9	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.1	2.0	1.2	-1.4	0.7	-0.0	1.3
Hair/balding pattern: Pattern 4	0.7	1.8	3.9	0.5	-1.0	-0.6	-1.8	2.0
Birth weight of first child	1.6	2.8	6.1	-2.5	-0.2	0.6	2.3	-1.5
Peak expiratory flow (PEF)	0.6	1.4	2.7	-0.8	-1.5	0.8	0.9	-1.6
Pulse wave reflection index	2.3	2.9	9.1	-1.5	-0.6	1.1	1.2	-3.0
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.8	1.2	1.4	0.8	0.5	0.4
Loud music exposure frequency	1.3	1.4	3.5	1.3	1.9	-0.6	1.0	0.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	-0.8	-0.8	0.3	-1.5	0.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	5.3	-2.3	-0.3	-0.5	0.1	-0.9
Blood clot in the leg (DVT)	2.0	2.6	4.7	1.3	0.4	-1.8	-1.8	2.2
Medication: Paracetamol	0.5	0.8	1.5	0.3	0.5	1.2	1.2	-0.7
Headache pain in last month	0.7	1.3	3.2	0.8	-0.5	1.8	1.5	0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.3	0.1	1.2	-0.4	0.8	-1.1
Glaucoma (self-reported)	0.4	0.4	1.4	0.7	1.2	-0.1	0.4	0.0
Gout (self-reported)	0.5	0.6	1.7	-0.1	-0.6	1.3	0.5	-0.9
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	4.3	-1.7	1.6	2.1	0.3	-1.1
Medication: Amlodipine	0.4	0.6	1.5	1.2	-0.4	-0.2	0.2	1.2
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.1	-0.3	0.6	-1.0	-1.2	-1.8
Birth weight	1.0	2.2	5.8	-2.4	-0.2	-1.8	0.4	-1.3
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.0	0.1	-1.3	-1.2	-1.4	0.6
High blood pressure (siblings)	1.0	1.4	2.6	-1.1	-0.1	1.1	1.6	-1.3
Forced vital capacity (FVC), Best measure	0.3	1.0	2.6	-1.6	-0.9	0.1	1.0	-0.8
Body fat percentage	0.4	1.6	4.4	0.6	-0.1	2.1	0.4	-1.8
Leg fat percentage (right)	0.4	1.5	6.8	0.4	-0.4	0.6	-0.3	-2.6
Arm fat-free mass (right)	0.2	0.9	1.5	-1.1	-1.1	0.2	-1.2	-0.9
Exposure to tobacco smoke outside home	1.3	1.7	3.8	1.8	-0.7	0.4	-0.9	2.0
Comparative body size at age 10	0.5	1.3	3.5	-0.3	1.4	1.9	-0.9	-0.0
Number of full brothers	0.8	1.0	2.0	1.0	-0.6	-1.2	-1.4	0.2
Worry too long after embarrassment	1.7	2.9	10.2	-0.2	-0.1	3.2	1.5	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-0.5	-0.3	1.0	0.9	-0.6
Wheeze or whistling in the chest in last year	0.4	0.7	2.1	0.3	-0.4	-0.1	-1.5	1.1
Number of children fathered	2.2	2.5	8.7	-1.8	-0.2	-0.5	0.6	-3.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.7	-0.1	-1.6	-0.1	0.2	-0.3
Age at first live birth	0.7	1.2	2.2	-1.0	1.5	0.3	-1.5	-0.7
Pulse wave peak to peak time	3.0	3.6	10.6	1.5	0.3	-1.2	-1.9	3.3
Health satisfaction	2.3	3.0	10.7	1.1	1.2	3.3	0.0	1.2
Shortness of breath walking on level ground	0.9	1.0	3.4	1.1	-0.2	-0.1	-0.7	1.9
Qualifications: College or University degree	1.1	3.6	13.5	-3.7	1.2	1.2	1.2	-0.5
Eye problems/disorders: None of the above	2.1	2.5	4.1	-1.4	-2.0	1.2	1.7	-1.4
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.0	-1.4	-0.9	-1.1	0.3	0.3
Emphysema/chronic bronchitis	1.1	1.2	3.4	0.6	1.8	-0.5	1.3	0.6
Medication for pain relief, constipation, heartburn	0.3	0.4	1.6	-0.6	0.1	-1.2	0.5	0.1
Neck or shoulder pain in last month	3.3	4.6	7.9	2.7	1.2	2.2	1.0	2.8
Medication: Blood pressure	0.2	0.3	0.8	0.3	-0.7	0.3	-0.5	0.9
Angina (self-reported)	0.6	0.8	1.4	-0.5	1.2	0.9	-1.0	0.8
Migraine (self-reported)	0.4	0.5	1.6	0.7	0.3	-1.3	0.4	-0.1
Medication: Ibuprofen	0.7	0.8	1.8	-0.3	0.9	1.3	1.1	-0.2
Medication: Allopurinol	0.9	1.2	2.4	-0.5	-1.1	1.5	0.9	-1.2
Medication: Omeprazole	1.6	1.9	5.1	1.0	-1.8	0.3	-2.3	0.0
Medication: Seretide 50 evohaler	0.9	1.1	2.1	1.5	1.1	0.1	-0.4	1.4
Mean time to correctly identify matches	2.3	4.3	7.5	2.7	-0.1	0.0	-2.7	2.6
Heart disease (mother)	1.8	2.2	4.0	-2.0	1.5	1.1	1.5	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.8	0.6	0.8	2.0	0.7	-1.1
Whole body fat mass	0.3	1.4	4.0	0.1	-0.5	2.0	-0.0	-1.7
Leg fat mass (right)	0.4	1.4	5.3	0.2	-0.3	1.3	-0.3	-2.3
Arm predicted mass (right)	0.2	0.9	1.3	-1.1	-1.1	0.0	-1.1	-0.8
Pulse rate, automated reading	0.1	0.5	1.1	0.2	-0.1	-1.0	-1.0	-0.2
Alcohol intake frequency.	0.1	0.2	0.7	0.8	-0.2	-0.3	0.6	-0.0
Comparative height size at age 10	0.1	0.7	1.3	-0.7	-0.1	1.1	0.5	-1.1
Number of full sisters	0.4	0.5	1.7	1.3	-0.3	-0.3	0.5	-0.4
Suffer from ‘nerves’	1.1	1.7	6.3	2.5	-0.3	0.8	-0.3	1.1
Overall health rating	1.6	3.5	5.9	2.4	-0.3	0.6	-2.4	2.3
Chest pain or discomfort	0.5	0.7	1.8	1.4	0.1	-0.8	-0.8	0.6
Had major operations	0.8	1.0	3.8	0.3	-0.7	-0.5	-1.9	-0.2
Age at last live birth	0.5	0.8	1.9	0.0	1.0	1.0	-1.4	-0.2
Family relationship satisfaction	1.4	1.7	3.4	1.8	1.3	-0.4	0.5	1.7
Leg pain on walking	0.6	0.7	2.2	0.6	1.5	0.1	1.1	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	2.2	-1.0	-1.5	1.4	-0.9	0.8
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.2	1.5	0.3	0.4	-1.1	1.8
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.0	-0.0	0.6	-1.4	-0.8	-1.4
Medication: Aspirin	0.5	0.7	2.4	0.1	0.4	0.4	-0.7	1.6
Supplements: Vitamin C	0.6	0.7	3.1	0.5	0.1	1.8	-0.1	-0.1
Knee pain experienced in last month	0.6	1.0	2.4	-0.5	0.0	1.2	1.6	0.9
Hypertension (Self-reported)	0.4	1.0	2.4	0.3	-0.8	1.0	-1.6	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	5.2	0.5	-2.3	-1.1	-1.4	-0.3
Illnesses of father: Heart disease	0.4	0.5	1.6	0.4	0.1	-0.7	-0.6	1.3
Illnesses of siblings: Diabetes	1.5	1.9	3.8	-2.0	-0.2	-1.5	-1.1	-1.4
Smoking status: Previous	3.5	5.2	10.9	-3.3	-0.5	2.0	-0.2	-3.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	-0.5	0.6	0.5	0.3	-0.0
Whole body fat-free mass	0.2	1.1	1.9	-1.4	-1.3	0.9	-0.8	-0.6
Leg fat-free mass (right)	0.3	1.6	4.5	-1.1	-1.1	2.1	0.2	-1.0
Arm fat percentage (left)	0.4	1.7	6.0	0.4	0.3	2.5	0.3	-1.5
Average weekly red wine intake	0.6	0.9	2.3	-1.0	1.5	0.1	-1.0	-0.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.0	1.2	1.7	1.2	-0.3	0.2
Mood swings	1.2	2.2	8.6	0.2	-0.0	2.9	0.2	1.5
Loneliness, isolation	1.6	2.1	4.1	1.2	-1.2	0.9	-1.7	2.0
Long-standing illness, disability or infirmity	0.6	1.0	3.2	1.2	0.6	0.0	-0.1	1.8
Ever had bowel cancer screening	2.6	3.1	6.1	-2.5	-2.1	1.6	0.9	-1.2
Diabetes diagnosed by doctor	0.9	1.4	3.8	-1.6	-0.8	-0.4	-2.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.6	-0.7	-0.7	0.8	0.1	-0.5
Friendships satisfaction	1.0	1.2	5.0	0.8	-0.1	0.2	0.4	2.2
Qualifications: nursing, teaching	0.6	0.9	3.1	-0.6	0.7	-0.5	-1.8	0.4
Commuting to job workplace: Walk	2.3	2.5	4.8	-1.2	-0.9	-0.9	2.2	-2.2
Eye problems/disorders: Cataract	1.1	1.2	3.6	0.3	1.3	-0.8	-0.5	1.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.5	0.1	-0.3	-0.4	0.7	0.0
Medication for cholesterol	0.4	0.6	0.9	0.3	0.9	-0.8	1.0	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.2	-0.4	-0.5	-1.1	1.1	-0.3
Back pain experienced in last month	0.9	1.2	3.8	0.2	0.8	1.9	1.3	0.3
Mineral and other dietary supplements	0.8	1.0	2.3	0.8	1.5	-1.4	0.4	0.3
Breast cancer (self-reported)	0.4	0.5	1.0	0.7	1.0	0.9	0.0	0.2
Asthma (self-reported)	0.5	1.0	1.9	-1.1	-0.5	1.1	-0.7	-1.4
Osteoporosis (self-reported)	0.4	0.5	2.1	0.0	-1.5	0.2	-0.5	0.0
Osteoarthritis (self-reported)	0.7	0.9	2.1	-0.5	-0.6	-0.4	1.5	-1.2
Medication: Aspirin	0.3	0.4	1.4	0.0	0.6	0.1	-0.5	1.2
Medication: Gliclazide	0.4	0.5	1.6	-0.8	0.3	-1.2	0.3	0.2
Illnesses of father: None of the above (group 1)	0.2	0.2	1.0	-0.3	0.1	-0.2	0.1	-1.0
Smoking status: Current	0.6	1.0	2.2	0.8	-1.5	-0.1	-0.6	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.4	0.0	-0.1	-0.6	-0.4	0.2
Whole body water mass	0.2	1.0	1.7	-1.3	-1.3	1.0	-0.7	-0.6
Leg predicted mass (right)	0.3	1.5	4.4	-1.1	-1.1	2.1	0.2	-0.9
Arm fat mass (left)	0.2	1.0	3.1	0.3	-0.3	1.8	-0.2	-1.2
Number of self-reported non-cancer illnesses	0.6	1.0	3.3	0.3	-0.5	1.8	-1.1	-0.5
Average weekly champagne plus white wine intake	0.6	0.8	2.5	-0.1	-0.4	-1.2	1.6	-0.0
Miserableness	1.4	2.5	9.9	1.1	1.1	0.2	-0.3	3.2
Guilty feelings	1.0	1.5	5.1	0.2	-1.4	2.3	0.5	0.1
Wears glasses or contact lenses	2.6	3.0	4.9	-2.2	0.4	2.1	0.9	-2.2
Ever taken oral contraceptive pill	0.5	0.5	1.2	-0.7	1.1	-0.1	-0.7	-0.7
Hearing aid user	1.7	1.9	4.8	-0.8	-1.5	-1.3	-0.2	-2.2
Mother’s age at death	0.2	0.3	0.8	0.2	-0.9	-0.7	0.1	0.0
Financial situation satisfaction	3.2	4.0	10.2	3.2	1.4	-0.5	-0.3	2.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	-0.1	0.4	1.1	0.6	0.3
Commuting to job workplace: Public transport	0.5	0.6	1.7	-1.3	0.9	-0.1	0.7	0.3
Eye problems/disorders: Glaucoma	1.2	1.5	5.9	0.3	2.4	-0.6	-0.9	-0.4
Medication: Blood pressure	0.6	1.2	3.6	-0.2	-1.2	-0.1	-1.9	0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.8	-0.3	0.6	0.1	0.9	0.0
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.5	0.3	-1.2	1.2	-1.1	1.2
High cholesterol (Self-reported)	0.8	1.4	3.1	0.5	0.5	0.9	-1.6	1.8
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.6	-0.7	0.3	-0.6	0.3
Medication: Paracetamol	1.0	1.6	4.3	-0.1	0.5	2.1	0.7	-1.7
Medication: Lisinopril	0.6	0.7	2.0	-1.3	-0.1	-0.0	1.4	-0.2
Medication: Atorvastatin	0.4	0.5	1.2	-1.1	0.6	0.8	-0.6	-0.1
Illnesses of father: High blood pressure	2.0	2.5	5.5	-1.7	-1.4	1.0	2.4	-1.1
Alcohol drinker status: Never	0.8	1.0	2.6	-0.6	0.6	0.8	1.6	-0.9
Ever smoked	1.4	2.5	5.4	-1.9	0.0	2.3	0.8	-1.8
Basal metabolic rate	0.2	1.0	1.4	-1.2	-1.1	1.2	-0.6	-0.9
Leg fat percentage (left)	0.4	1.4	5.5	0.6	-0.5	0.8	-0.1	-2.4
Arm fat-free mass (left)	0.1	0.7	1.3	-0.7	-1.1	0.1	-1.0	-0.7
Number of operations (self-reported)	0.5	0.8	2.2	0.9	-0.6	0.2	-1.5	0.7
Average weekly beer plus cider intake	1.6	2.4	7.0	2.7	1.0	0.9	-1.0	1.4
Irritability	1.1	1.9	5.5	0.2	1.0	2.4	1.5	0.9
Risk taking	1.2	1.7	3.6	-1.3	-1.7	-1.9	0.6	0.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.5	-0.7	-0.6	-1.6	0.9	0.1
Fractured/broken bones in last 5 years	0.8	1.0	2.5	-0.7	-0.7	0.4	-1.1	1.6
Age started oral contraceptive pill	0.4	0.4	0.7	0.7	0.5	-0.8	-0.5	-0.6
Diastolic blood pressure, automated reading	0.3	1.0	2.8	1.4	0.3	-1.7	-0.1	-0.6
Ever depressed for a whole week	0.8	1.0	2.5	0.1	-1.6	-0.7	-0.1	1.3
Unable to work because of sickness or disability	1.0	1.3	4.0	1.1	0.0	2.0	-0.4	1.1
Commuting to job workplace: Cycle	2.9	3.5	9.1	-3.0	-0.6	0.2	2.5	-1.3
Myopia	1.0	1.4	2.9	-1.7	0.9	1.5	1.0	0.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.8	-0.5	0.6	0.1	2.0	-1.0
Cholesterol lowering medication	0.6	0.9	1.8	-0.1	0.5	1.2	-0.8	1.3
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	7.0	0.7	-1.5	0.1	-2.6	-0.4
Pain experienced in last month	1.0	1.6	2.9	-1.3	-1.1	-1.4	-1.7	-0.7
Supplements: Calcium	0.4	0.4	1.2	0.0	-1.1	-0.5	0.7	-0.0
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	-0.6	0.5	0.2	-0.3	-0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.2	1.1	-0.9	-1.0	-0.5	0.6
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	5.5	1.4	0.4	-1.7	-1.9	2.3
Heart disease (siblings)	0.1	0.1	0.3	-0.2	0.0	0.5	0.6	0.2
Alcohol drinker status: Previous	0.6	0.7	2.8	-0.5	-0.5	1.7	0.4	-0.3
Pack years of smoking	2.1	3.1	8.7	2.5	0.2	0.1	-0.6	2.9
Impedance of whole body	0.2	0.8	1.6	1.3	0.7	-0.4	1.1	0.8
Leg fat mass (left)	0.4	1.5	5.3	0.1	-0.5	1.3	-0.1	-2.3
Arm predicted mass (left)	0.1	0.7	1.6	-0.9	-1.3	-0.2	-0.8	-0.7