Hub : Genes

EGFR

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1010 0.0330 3.4e-04 0.003 0.041 0.044 0.042 0.026 1.1e-01 7.9e-06 3.6e-06 6.1e-06 3.8e-04
2 GTEx Artery Aorta 0.1700 0.0680 9.9e-03 0.000 NA -0.005 NA 0.003 3.2e-01 NA 7.9e-01 NA 2.0e-01
3 GTEx Muscle Skeletal 0.0864 0.0328 3.4e-03 -0.003 NA 0.000 NA -0.002 8.5e-01 NA 3.0e-01 NA 6.3e-01
4 GTEx Nerve Tibial 0.1829 0.0487 3.0e-05 0.040 NA 0.079 NA 0.099 7.5e-04 NA 3.1e-06 NA 1.8e-07
5 ROSMAP Brain Pre-frontal Cortex 0.1581 0.0358 1.6e-08 0.034 0.076 0.086 0.078 0.058 3.2e-05 5.2e-10 3.2e-11 3.2e-10 5.9e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.1 0.2 0.8 0.2 -0.9 -0.2 -0.3 0.2
Bipolar Disorder or Schizophrenia 0.4 1.0 3.7 0.2 -1.9 -0.6 -0.8 0.3
Depressed Affect (Nagel 2018) 1.1 2.3 6.7 0.8 0.7 2.6 -0.7 1.8
Depression (Nagel 2018) 0.7 1.0 3.3 0.5 0.0 1.8 -1.2 0.6
Intelligence (Savage-Jansen 2018) 1.3 3.9 12.0 -3.5 0.6 -0.3 2.3 -1.4
Neuroticism (Nagel 2018) 1.2 2.7 7.8 1.7 0.2 2.8 -0.4 1.7
Schizophrenia (2018) 0.4 0.8 3.0 0.0 -1.7 -0.5 -0.8 0.2
Schizophrenia vs Biploar Disorder 0.1 0.1 0.4 -0.2 0.2 -0.2 -0.7 -0.1
Worry (Nagel 2018) 1.8 3.7 11.1 3.3 -0.0 1.8 -0.9 1.9
Alzheimer’s Disease (in mother) 2.2 2.6 8.5 2.9 0.3 0.6 1.0 1.7
Alzheimer’s Disease (in father) 2.1 2.2 6.4 2.5 1.1 1.0 -0.2 1.6
Alzheimer’s Disease (including proxy) 3.9 5.7 20.8 4.6 0.9 0.3 0.7 2.5
Crohns Disease (2017) 0.4 1.0 2.4 0.9 1.1 -1.6 -0.2 0.5
Irritable Bowel Disease (IBD) 0.2 0.4 1.2 0.7 0.2 -1.1 -0.5 0.4
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.0 -0.6 -0.2 -0.6 0.4
Major Depression (MDD) 2.2 2.7 6.4 -0.5 -2.2 2.5 -0.6 -1.3
Reaction Time 2.6 5.0 9.9 3.1 0.3 -0.2 -2.8 2.6
Verbal and Numeric Reasoning (VNR) 1.2 2.9 7.4 -2.7 0.1 1.5 2.3 -0.1
Breast Cancer 0.3 0.8 2.7 -0.4 -0.0 -1.6 -0.5 0.9
Ovarian Cancer 0.4 0.6 1.9 -0.2 0.7 0.5 1.4 0.3
Prostate Cancer 1.7 2.3 4.4 -1.8 -1.4 0.5 -1.4 -2.1
Age at First Birth 0.9 1.3 4.5 -1.1 0.4 0.8 -2.1 0.1
Bipolar Disorder (2011) 2.5 2.5 11.9 -0.3 -3.5 -0.2 0.3 -0.4
Body Mass Index (BMI) (2010) 0.5 0.7 3.3 -0.1 -0.1 -0.2 1.8 -0.3
Coronary Artery Disease (CAD) 0.7 0.9 2.6 0.2 0.7 -1.6 -1.0 -0.0
Crohns Disease (2012) 0.6 1.0 3.0 1.7 0.6 -1.2 0.1 0.4
Mean Putamen Volume 3.2 3.6 7.5 -1.9 2.4 2.7 0.6 -1.0
Fasting Glucose 0.6 0.7 1.1 0.9 -0.1 -1.0 -1.0 1.1
HbA1C 0.9 1.0 2.9 -0.6 0.2 0.5 -1.7 -1.1
HDL Cholesterol 0.3 0.4 1.3 -0.1 1.2 -0.7 -0.6 -0.2
LDL Cholesterol 1.4 2.2 4.7 -0.9 -1.9 -2.2 0.1 1.4
Lupus 0.3 0.4 0.9 0.1 0.4 0.9 -0.9 0.3
Neuroticism (2016) 0.3 0.4 0.7 0.0 0.3 0.9 -0.7 0.8
Primary Biliary Cirrhosis 0.9 1.2 2.4 1.6 -0.2 -1.3 -0.9 1.1
Rheumatoid Arthritis 0.7 0.9 2.6 -0.0 -0.1 -1.0 -1.6 1.0
Schizophrenia (2014) 0.5 1.1 3.6 -0.2 -1.9 -0.9 -1.1 0.0
Triglycerides 1.4 2.2 5.3 1.4 -0.5 -1.9 -0.5 2.3
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.9 -0.0 -1.7 -1.1 -0.5 -0.1
Ulcerative Colitis 0.9 1.3 2.1 0.7 -1.0 -1.2 -1.1 1.4
Blood Eosinophil Count 0.1 1.0 4.0 -0.8 -0.2 2.0 0.3 0.5
Blood Platelet Count 0.2 2.8 11.8 -0.5 0.6 1.2 -3.4 0.4
Blood Red Count 0.1 1.1 2.7 0.7 1.4 0.3 1.6 -0.4
Blood White Count 0.4 2.9 5.0 1.4 1.4 2.0 -2.2 1.1
Heel T-Score 1.3 10.7 30.0 1.8 2.6 -5.5 -2.4 2.8
BMI 0.5 2.7 7.2 -1.0 -1.4 2.7 0.1 -1.8
Height 0.1 1.3 2.6 -0.8 0.7 1.4 -1.6 0.8
Waist Hip Ratio (WHR) 0.1 0.6 1.4 1.2 -0.9 0.4 -0.7 0.3
Systolic Blood Pressure 0.4 1.8 6.6 1.1 -0.4 -2.6 0.8 0.8
Smoking Status 0.4 1.0 1.8 -1.4 -1.2 1.1 -0.6 -0.4
Allergy or Eczema 0.4 1.1 2.7 -0.1 -1.5 1.7 -0.2 0.4
Cardiovascular Disease 0.4 1.3 2.0 -0.4 -0.9 1.4 -1.3 1.3
Hypothyroidism (self reported) 0.4 0.9 2.2 -1.5 0.3 1.4 0.2 -0.7
Respiratory disease 0.4 1.0 1.9 -0.5 -0.8 0.5 -1.4 -1.3
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.2 -0.9 -0.5 -0.7 -1.1 0.5
Lung FEV1/FVC ratio 0.4 2.0 4.5 0.7 1.8 -0.2 -2.1 -1.4
Lung FVC 0.1 0.4 0.9 -0.5 -0.7 0.4 0.4 -0.9
Neuroticism 1.4 3.4 7.6 2.3 0.5 2.8 -0.3 2.0
Chronotype (morning person) 1.3 2.9 9.8 -2.0 -0.5 0.7 -0.5 -3.1
Hair Pigment 0.1 2.1 6.7 0.5 -0.2 1.9 2.6 -0.1
Tanning 0.2 2.2 4.1 -1.9 -0.0 1.2 1.5 -2.0
Hand grip strength (left) 0.4 1.1 5.2 -0.3 0.2 -2.3 -0.3 -0.2
Number of treatments/medications taken 0.7 1.3 3.0 0.5 -0.2 1.4 -1.7 1.0
Average weekly spirits intake 0.1 0.1 0.2 0.4 -0.2 0.5 -0.3 -0.1
Sensitivity / hurt feelings 0.1 0.2 0.7 0.3 -0.6 0.8 -0.1 -0.1
Frequency of depressed mood in last 2 weeks 0.7 0.9 3.4 0.5 0.4 1.9 -0.5 0.7
Hearing difficulty/problems: Yes 0.6 0.9 2.2 1.5 -0.8 0.3 -0.2 1.4
Relative age of first facial hair 0.5 1.0 2.3 -1.2 -0.6 0.7 0.8 -1.5
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.3 -1.1 -0.4 0.8 0.5 -0.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 3.4 0.1 -1.8 0.8 -0.4 0.1
Ever had hysterectomy (womb removed) 0.6 0.7 2.6 0.4 0.5 1.6 0.4 -0.3
Systolic blood pressure, automated reading 0.7 2.1 6.0 2.0 0.6 -2.5 -0.3 0.1
Eye problems/disorders: Diabetes related eye disease 1.0 1.0 4.3 0.2 0.1 -0.2 -2.1 0.9
Angina 0.6 0.8 1.3 -0.5 1.1 0.6 -1.0 1.0
Medication for hormone replacement therapy 0.8 0.9 2.8 -0.7 -1.7 -0.3 0.6 -0.9
Vitamin and mineral supplements 0.5 0.7 2.2 0.5 1.0 -1.5 -0.4 0.1
Supplements: Zinc 1.1 1.2 4.2 0.6 -2.1 1.1 0.2 0.1
Medication: Co-codamol 0.8 0.9 2.0 -1.2 -0.3 0.9 1.4 -0.7
Medication: Metformin 0.3 0.5 1.1 -0.8 -0.1 -0.6 -1.1 0.4
Diabetes (father) 0.4 0.5 0.9 -0.8 -1.0 -0.1 -0.5 0.8
Diabetes (mother) 1.0 1.2 3.0 0.2 -1.7 1.5 -0.7 -0.3
Severe depression (siblings) 0.6 0.6 1.9 0.8 1.4 0.5 0.2 0.5
Pack years adult smoking proportion 2.1 3.2 8.9 2.6 -0.1 0.3 -0.6 3.0
Impedance of leg (right) 0.2 1.2 4.0 1.2 0.6 -2.0 0.1 0.2
Leg fat-free mass (left) 0.3 1.8 5.2 -1.3 -0.9 2.3 0.0 -1.2
Trunk fat percentage 0.5 1.9 6.2 0.7 0.2 2.5 0.7 -1.5
Hand grip strength (right) 0.1 0.4 1.0 0.3 0.3 -1.0 -0.6 0.7
Townsend deprivation index at recruitment 1.3 1.8 3.0 0.1 -1.7 1.6 1.7 -0.5
Current tobacco smoking 0.5 0.9 2.5 0.8 -1.6 0.2 -0.3 1.1
Average weekly fortified wine intake 0.6 0.7 1.4 0.4 0.4 -0.8 -1.0 1.2
Maternal smoking around birth 1.0 1.5 6.2 0.1 -2.5 -0.5 -0.9 0.6
Fed-up feelings 1.2 2.2 4.2 1.1 0.6 1.8 -2.1 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 1.5 0.8 -0.5 1.1 -1.2 1.2
Relative age voice broke 1.0 1.5 3.0 -1.7 0.4 1.1 0.6 -1.7
Taking other prescription medications 0.4 0.6 2.4 0.3 -0.3 -0.4 -1.5 0.6
Age when periods started (menarche) 0.6 1.5 3.0 1.7 -0.1 -0.7 -1.5 1.4
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.2 1.1 -0.6 0.5 0.3 0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.4 9.4 -0.9 -1.2 -3.1 -0.4 -0.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.9 0.6 -0.6 0.5 -0.5 -1.0
Qualifications: CSEs or equivalent 0.6 0.8 2.7 0.3 -0.1 1.6 -0.2 1.0
Serious illness, injury or assault to yourself 0.3 0.3 1.2 -0.1 0.1 1.1 -0.1 0.6
High blood pressure 0.3 0.9 2.5 0.6 -0.9 0.6 -1.6 0.9
Hayfever, allergic rhinitis or eczema 0.5 1.2 2.5 -0.7 -1.5 1.6 -0.5 0.3
Multivitamins +/- minerals 0.5 0.6 2.8 -0.3 -1.7 0.3 0.0 0.2
Stomach or abdominal pain in last month 0.2 0.3 0.9 -0.9 0.1 0.0 -0.5 -0.6
Supplements: Glucosamine 0.2 0.3 1.3 -0.1 -1.2 0.4 -0.2 0.2
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 6.0 -0.5 0.4 -2.4 -0.9 0.1
Medication: Atenolol 1.5 1.9 3.9 1.2 0.5 -0.4 -1.9 2.0
Medication: Levothyroxine sodium 1.4 2.4 5.2 -1.5 1.9 2.3 -0.4 -0.6
Sitting height 0.2 1.6 4.3 -2.1 -1.3 -1.1 -0.7 0.4
Chronic bronchitis/emphysema (father) 1.1 1.3 5.6 0.5 2.4 0.6 -0.0 -0.0
High blood pressure (mother) 0.4 0.6 1.3 0.3 0.6 1.1 1.1 0.1
Body mass index (BMI) 0.3 1.2 3.1 0.1 -0.3 1.8 -0.3 -1.6
Impedance of leg (left) 0.3 1.4 4.5 1.4 0.3 -2.1 0.4 0.4
Leg predicted mass (left) 0.3 1.8 5.0 -1.3 -0.9 2.2 0.1 -1.2
Trunk fat mass 0.3 1.4 4.8 0.2 -0.3 2.2 0.3 -1.5
Waist circumference 0.3 1.0 1.5 0.2 -1.1 1.2 -1.2 -0.9
Number of incorrect matches in round 0.3 0.5 1.1 0.9 -0.5 -0.1 -1.1 0.6
Past tobacco smoking 2.5 4.6 9.4 3.1 0.4 -2.4 -0.1 2.8
Alcohol usually taken with meals 0.4 0.6 2.3 -1.5 0.3 0.2 -0.3 -0.7
Nervous feelings 0.9 1.7 4.0 2.0 -0.6 1.7 -0.4 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.4 0.3 0.7 1.5 1.3 0.3
Hearing difficulty/problems with background noise 1.1 1.7 5.0 2.2 0.0 -1.3 0.5 1.3
Hair/balding pattern: Pattern 2 2.1 2.7 7.2 0.7 -2.3 2.7 -0.1 0.2
Had menopause 0.5 0.7 1.3 0.4 -1.1 -0.7 -1.1 -0.3
Had other major operations 0.2 0.2 0.5 0.5 0.3 -0.7 -0.1 0.7
Forced vital capacity (FVC) 0.4 1.4 2.2 -1.3 -1.2 0.3 1.5 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 5.7 -0.2 -1.0 -2.4 -0.5 0.1
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.2 0.8 -0.5 0.8 0.3 1.1
Qualifications: None of the above 0.2 0.5 1.7 1.3 -0.6 0.0 0.1 -0.6
Financial difficulties in last 2 years 0.7 1.0 3.3 1.0 -0.8 -0.2 -0.1 1.8
Mouth/teeth dental problems 0.5 0.8 1.9 -0.2 -0.4 1.3 0.1 -1.4
Heart attack 0.6 0.8 1.2 1.1 -0.7 -1.1 -0.6 0.8
Allergy 0.4 1.0 1.8 0.9 1.2 -1.3 0.8 -0.0
Pain all over the body in last month 0.2 0.3 0.5 0.7 0.6 -0.1 -0.6 -0.3
Diabetes (self-reported) 0.7 1.1 3.8 -0.6 -1.2 0.0 -2.0 0.1
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 4.9 -0.8 -0.1 2.2 0.5 -1.1
Medication: Ramipril 3.3 4.2 9.4 1.0 -2.0 -0.4 -3.1 2.5
Medication: Simvastatin 0.8 1.1 2.3 0.6 -0.5 0.8 -1.4 1.5
Fluid intelligence score 1.4 2.9 11.8 -1.4 0.6 0.7 3.4 -0.3
Illnesses of siblings 1.3 1.8 5.2 2.3 0.9 -0.2 -0.9 1.4
Neuroticism score 1.6 3.4 13.2 1.3 0.2 3.6 0.5 1.2
Weight 0.3 1.4 3.7 -0.6 -0.6 1.9 -0.4 -1.5
Impedance of arm (right) 0.2 1.1 3.4 0.9 0.4 0.5 1.8 1.0
Arm fat percentage (right) 0.3 1.4 4.8 0.7 0.2 2.2 0.5 -1.1
Trunk fat-free mass 0.3 1.4 3.0 -1.7 -1.4 -0.1 -1.5 -0.2
Hip circumference 0.4 1.5 3.8 -1.1 -0.3 1.6 -0.3 -1.9
Time employed in main current job 0.6 0.7 1.3 0.7 0.8 1.2 1.0 -0.3
Alcohol intake versus 10 years previously 0.2 0.4 0.8 0.7 0.9 -0.6 0.2 0.1
Father’s age at death 1.1 1.4 2.7 -1.6 1.0 1.4 0.4 -1.1
Worrier / anxious feelings 1.2 2.2 8.3 0.7 0.3 2.9 0.0 1.5
Frequency of tiredness / lethargy in last 2 weeks 1.8 2.9 7.0 1.6 0.9 1.9 -0.7 2.6
Falls in the last year 0.7 0.9 2.3 -1.1 1.5 0.1 0.7 -0.6
Hair/balding pattern: Pattern 3 1.5 2.2 5.0 -0.3 2.2 -2.1 1.2 -0.0
Number of live births 0.8 1.1 2.0 1.1 1.4 -1.3 -0.0 0.6
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 2.2 -1.2 -0.9 0.4 1.0 -1.5
Pulse rate 0.5 0.8 1.7 1.3 -1.2 -0.8 -0.3 0.4
Happiness 2.7 3.3 7.8 2.7 1.1 0.3 -0.1 2.8
Noisy workplace 0.7 0.9 3.1 0.5 0.2 1.8 -0.6 0.7
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.3 -1.5 1.2 0.7 -0.2 0.0
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.4 -1.9 1.1 1.7 0.2 0.1
Mouth/teeth dental problems: Dentures 1.1 1.8 3.9 1.4 0.6 -2.0 -0.5 1.6
Asthma 0.4 0.8 1.7 -0.9 -0.1 0.8 -0.8 -1.3
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.6 0.8 1.3 1.2 0.7 0.5
Medication: Cholesterol lowering 0.8 1.2 3.3 -0.2 -1.5 0.1 -1.8 0.7
Depression (self-reported) 1.6 1.9 7.4 0.2 -2.7 0.4 -1.0 0.9
Medication: Lansoprazole 0.4 0.4 1.1 0.6 -0.2 -0.9 -1.0 0.3
Prospective memory result 0.7 0.9 2.9 0.4 -1.1 -1.7 0.2 -0.5
Lung cancer (father) 0.6 0.6 2.8 -0.2 0.3 -1.7 -0.2 -0.5
Illnesses of mother 0.4 0.4 1.2 -0.2 0.6 -1.1 -0.5 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.2 -1.1 -0.4 0.0 0.2 -0.7
Pulse wave Arterial Stiffness index 2.6 3.1 8.7 -1.3 -0.1 1.0 2.0 -3.0
Impedance of arm (left) 0.2 0.9 1.6 0.6 0.9 1.1 1.3 0.8
Arm fat mass (right) 0.3 1.2 4.2 0.2 0.1 2.0 0.2 -1.3
Trunk predicted mass 0.2 1.3 2.5 -1.6 -1.4 -0.1 -1.4 -0.2
Standing height 0.1 0.9 3.3 -1.8 -0.8 0.7 0.0 -0.2
Length of working week for main job 1.1 1.2 2.8 -0.5 -0.6 -1.7 -1.6 0.5
Exposure to tobacco smoke at home 0.2 0.2 0.7 0.3 0.2 0.2 0.8 -0.0
Breastfed as a baby 1.8 2.2 6.5 -2.5 -0.4 0.6 1.7 -1.2
Tense / ‘highly strung’ 0.9 1.5 3.6 1.2 -0.5 1.5 1.9 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.1 2.0 1.2 -1.4 0.7 -0.0 1.3
Hair/balding pattern: Pattern 4 0.7 1.8 3.9 0.5 -1.0 -0.6 -1.8 2.0
Birth weight of first child 1.6 2.8 6.1 -2.5 -0.2 0.6 2.3 -1.5
Peak expiratory flow (PEF) 0.6 1.4 2.7 -0.8 -1.5 0.8 0.9 -1.6
Pulse wave reflection index 2.3 2.9 9.1 -1.5 -0.6 1.1 1.2 -3.0
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.8 1.2 1.4 0.8 0.5 0.4
Loud music exposure frequency 1.3 1.4 3.5 1.3 1.9 -0.6 1.0 0.7
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.3 -0.8 -0.8 0.3 -1.5 0.3
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 5.3 -2.3 -0.3 -0.5 0.1 -0.9
Blood clot in the leg (DVT) 2.0 2.6 4.7 1.3 0.4 -1.8 -1.8 2.2
Medication: Paracetamol 0.5 0.8 1.5 0.3 0.5 1.2 1.2 -0.7
Headache pain in last month 0.7 1.3 3.2 0.8 -0.5 1.8 1.5 0.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.3 0.1 1.2 -0.4 0.8 -1.1
Glaucoma (self-reported) 0.4 0.4 1.4 0.7 1.2 -0.1 0.4 0.0
Gout (self-reported) 0.5 0.6 1.7 -0.1 -0.6 1.3 0.5 -0.9
Hypothyroidism/myxoedema (self-reported) 1.1 2.1 4.3 -1.7 1.6 2.1 0.3 -1.1
Medication: Amlodipine 0.4 0.6 1.5 1.2 -0.4 -0.2 0.2 1.2
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.1 -0.3 0.6 -1.0 -1.2 -1.8
Birth weight 1.0 2.2 5.8 -2.4 -0.2 -1.8 0.4 -1.3
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.0 0.1 -1.3 -1.2 -1.4 0.6
High blood pressure (siblings) 1.0 1.4 2.6 -1.1 -0.1 1.1 1.6 -1.3
Forced vital capacity (FVC), Best measure 0.3 1.0 2.6 -1.6 -0.9 0.1 1.0 -0.8
Body fat percentage 0.4 1.6 4.4 0.6 -0.1 2.1 0.4 -1.8
Leg fat percentage (right) 0.4 1.5 6.8 0.4 -0.4 0.6 -0.3 -2.6
Arm fat-free mass (right) 0.2 0.9 1.5 -1.1 -1.1 0.2 -1.2 -0.9
Exposure to tobacco smoke outside home 1.3 1.7 3.8 1.8 -0.7 0.4 -0.9 2.0
Comparative body size at age 10 0.5 1.3 3.5 -0.3 1.4 1.9 -0.9 -0.0
Number of full brothers 0.8 1.0 2.0 1.0 -0.6 -1.2 -1.4 0.2
Worry too long after embarrassment 1.7 2.9 10.2 -0.2 -0.1 3.2 1.5 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.0 -0.5 -0.3 1.0 0.9 -0.6
Wheeze or whistling in the chest in last year 0.4 0.7 2.1 0.3 -0.4 -0.1 -1.5 1.1
Number of children fathered 2.2 2.5 8.7 -1.8 -0.2 -0.5 0.6 -3.0
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.7 -0.1 -1.6 -0.1 0.2 -0.3
Age at first live birth 0.7 1.2 2.2 -1.0 1.5 0.3 -1.5 -0.7
Pulse wave peak to peak time 3.0 3.6 10.6 1.5 0.3 -1.2 -1.9 3.3
Health satisfaction 2.3 3.0 10.7 1.1 1.2 3.3 0.0 1.2
Shortness of breath walking on level ground 0.9 1.0 3.4 1.1 -0.2 -0.1 -0.7 1.9
Qualifications: College or University degree 1.1 3.6 13.5 -3.7 1.2 1.2 1.2 -0.5
Eye problems/disorders: None of the above 2.1 2.5 4.1 -1.4 -2.0 1.2 1.7 -1.4
Mouth/teeth dental problems: Loose teeth 0.7 0.9 2.0 -1.4 -0.9 -1.1 0.3 0.3
Emphysema/chronic bronchitis 1.1 1.2 3.4 0.6 1.8 -0.5 1.3 0.6
Medication for pain relief, constipation, heartburn 0.3 0.4 1.6 -0.6 0.1 -1.2 0.5 0.1
Neck or shoulder pain in last month 3.3 4.6 7.9 2.7 1.2 2.2 1.0 2.8
Medication: Blood pressure 0.2 0.3 0.8 0.3 -0.7 0.3 -0.5 0.9
Angina (self-reported) 0.6 0.8 1.4 -0.5 1.2 0.9 -1.0 0.8
Migraine (self-reported) 0.4 0.5 1.6 0.7 0.3 -1.3 0.4 -0.1
Medication: Ibuprofen 0.7 0.8 1.8 -0.3 0.9 1.3 1.1 -0.2
Medication: Allopurinol 0.9 1.2 2.4 -0.5 -1.1 1.5 0.9 -1.2
Medication: Omeprazole 1.6 1.9 5.1 1.0 -1.8 0.3 -2.3 0.0
Medication: Seretide 50 evohaler 0.9 1.1 2.1 1.5 1.1 0.1 -0.4 1.4
Mean time to correctly identify matches 2.3 4.3 7.5 2.7 -0.1 0.0 -2.7 2.6
Heart disease (mother) 1.8 2.2 4.0 -2.0 1.5 1.1 1.5 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.8 0.6 0.8 2.0 0.7 -1.1
Whole body fat mass 0.3 1.4 4.0 0.1 -0.5 2.0 -0.0 -1.7
Leg fat mass (right) 0.4 1.4 5.3 0.2 -0.3 1.3 -0.3 -2.3
Arm predicted mass (right) 0.2 0.9 1.3 -1.1 -1.1 0.0 -1.1 -0.8
Pulse rate, automated reading 0.1 0.5 1.1 0.2 -0.1 -1.0 -1.0 -0.2
Alcohol intake frequency. 0.1 0.2 0.7 0.8 -0.2 -0.3 0.6 -0.0
Comparative height size at age 10 0.1 0.7 1.3 -0.7 -0.1 1.1 0.5 -1.1
Number of full sisters 0.4 0.5 1.7 1.3 -0.3 -0.3 0.5 -0.4
Suffer from ‘nerves’ 1.1 1.7 6.3 2.5 -0.3 0.8 -0.3 1.1
Overall health rating 1.6 3.5 5.9 2.4 -0.3 0.6 -2.4 2.3
Chest pain or discomfort 0.5 0.7 1.8 1.4 0.1 -0.8 -0.8 0.6
Had major operations 0.8 1.0 3.8 0.3 -0.7 -0.5 -1.9 -0.2
Age at last live birth 0.5 0.8 1.9 0.0 1.0 1.0 -1.4 -0.2
Family relationship satisfaction 1.4 1.7 3.4 1.8 1.3 -0.4 0.5 1.7
Leg pain on walking 0.6 0.7 2.2 0.6 1.5 0.1 1.1 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 2.2 -1.0 -1.5 1.4 -0.9 0.8
Commuting to job workplace: Car/motor vehicle 1.2 1.4 3.2 1.5 0.3 0.4 -1.1 1.8
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.0 -0.0 0.6 -1.4 -0.8 -1.4
Medication: Aspirin 0.5 0.7 2.4 0.1 0.4 0.4 -0.7 1.6
Supplements: Vitamin C 0.6 0.7 3.1 0.5 0.1 1.8 -0.1 -0.1
Knee pain experienced in last month 0.6 1.0 2.4 -0.5 0.0 1.2 1.6 0.9
Hypertension (Self-reported) 0.4 1.0 2.4 0.3 -0.8 1.0 -1.6 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.7 5.2 0.5 -2.3 -1.1 -1.4 -0.3
Illnesses of father: Heart disease 0.4 0.5 1.6 0.4 0.1 -0.7 -0.6 1.3
Illnesses of siblings: Diabetes 1.5 1.9 3.8 -2.0 -0.2 -1.5 -1.1 -1.4
Smoking status: Previous 3.5 5.2 10.9 -3.3 -0.5 2.0 -0.2 -3.3
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.4 -0.5 0.6 0.5 0.3 -0.0
Whole body fat-free mass 0.2 1.1 1.9 -1.4 -1.3 0.9 -0.8 -0.6
Leg fat-free mass (right) 0.3 1.6 4.5 -1.1 -1.1 2.1 0.2 -1.0
Arm fat percentage (left) 0.4 1.7 6.0 0.4 0.3 2.5 0.3 -1.5
Average weekly red wine intake 0.6 0.9 2.3 -1.0 1.5 0.1 -1.0 -0.2
Handedness (chirality/laterality): Left-handed 1.0 1.2 3.0 1.2 1.7 1.2 -0.3 0.2
Mood swings 1.2 2.2 8.6 0.2 -0.0 2.9 0.2 1.5
Loneliness, isolation 1.6 2.1 4.1 1.2 -1.2 0.9 -1.7 2.0
Long-standing illness, disability or infirmity 0.6 1.0 3.2 1.2 0.6 0.0 -0.1 1.8
Ever had bowel cancer screening 2.6 3.1 6.1 -2.5 -2.1 1.6 0.9 -1.2
Diabetes diagnosed by doctor 0.9 1.4 3.8 -1.6 -0.8 -0.4 -2.0 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.6 -0.7 -0.7 0.8 0.1 -0.5
Friendships satisfaction 1.0 1.2 5.0 0.8 -0.1 0.2 0.4 2.2
Qualifications: nursing, teaching 0.6 0.9 3.1 -0.6 0.7 -0.5 -1.8 0.4
Commuting to job workplace: Walk 2.3 2.5 4.8 -1.2 -0.9 -0.9 2.2 -2.2
Eye problems/disorders: Cataract 1.1 1.2 3.6 0.3 1.3 -0.8 -0.5 1.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.5 0.1 -0.3 -0.4 0.7 0.0
Medication for cholesterol 0.4 0.6 0.9 0.3 0.9 -0.8 1.0 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.2 -0.4 -0.5 -1.1 1.1 -0.3
Back pain experienced in last month 0.9 1.2 3.8 0.2 0.8 1.9 1.3 0.3
Mineral and other dietary supplements 0.8 1.0 2.3 0.8 1.5 -1.4 0.4 0.3
Breast cancer (self-reported) 0.4 0.5 1.0 0.7 1.0 0.9 0.0 0.2
Asthma (self-reported) 0.5 1.0 1.9 -1.1 -0.5 1.1 -0.7 -1.4
Osteoporosis (self-reported) 0.4 0.5 2.1 0.0 -1.5 0.2 -0.5 0.0
Osteoarthritis (self-reported) 0.7 0.9 2.1 -0.5 -0.6 -0.4 1.5 -1.2
Medication: Aspirin 0.3 0.4 1.4 0.0 0.6 0.1 -0.5 1.2
Medication: Gliclazide 0.4 0.5 1.6 -0.8 0.3 -1.2 0.3 0.2
Illnesses of father: None of the above (group 1) 0.2 0.2 1.0 -0.3 0.1 -0.2 0.1 -1.0
Smoking status: Current 0.6 1.0 2.2 0.8 -1.5 -0.1 -0.6 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.4 0.0 -0.1 -0.6 -0.4 0.2
Whole body water mass 0.2 1.0 1.7 -1.3 -1.3 1.0 -0.7 -0.6
Leg predicted mass (right) 0.3 1.5 4.4 -1.1 -1.1 2.1 0.2 -0.9
Arm fat mass (left) 0.2 1.0 3.1 0.3 -0.3 1.8 -0.2 -1.2
Number of self-reported non-cancer illnesses 0.6 1.0 3.3 0.3 -0.5 1.8 -1.1 -0.5
Average weekly champagne plus white wine intake 0.6 0.8 2.5 -0.1 -0.4 -1.2 1.6 -0.0
Miserableness 1.4 2.5 9.9 1.1 1.1 0.2 -0.3 3.2
Guilty feelings 1.0 1.5 5.1 0.2 -1.4 2.3 0.5 0.1
Wears glasses or contact lenses 2.6 3.0 4.9 -2.2 0.4 2.1 0.9 -2.2
Ever taken oral contraceptive pill 0.5 0.5 1.2 -0.7 1.1 -0.1 -0.7 -0.7
Hearing aid user 1.7 1.9 4.8 -0.8 -1.5 -1.3 -0.2 -2.2
Mother’s age at death 0.2 0.3 0.8 0.2 -0.9 -0.7 0.1 0.0
Financial situation satisfaction 3.2 4.0 10.2 3.2 1.4 -0.5 -0.3 2.7
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.3 -0.1 0.4 1.1 0.6 0.3
Commuting to job workplace: Public transport 0.5 0.6 1.7 -1.3 0.9 -0.1 0.7 0.3
Eye problems/disorders: Glaucoma 1.2 1.5 5.9 0.3 2.4 -0.6 -0.9 -0.4
Medication: Blood pressure 0.6 1.2 3.6 -0.2 -1.2 -0.1 -1.9 0.9
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.8 -0.3 0.6 0.1 0.9 0.0
Supplements: Fish oil (including cod liver oil) 0.9 1.2 1.5 0.3 -1.2 1.2 -1.1 1.2
High cholesterol (Self-reported) 0.8 1.4 3.1 0.5 0.5 0.9 -1.6 1.8
Medication: Bendroflumethiazide 0.2 0.3 0.5 0.6 -0.7 0.3 -0.6 0.3
Medication: Paracetamol 1.0 1.6 4.3 -0.1 0.5 2.1 0.7 -1.7
Medication: Lisinopril 0.6 0.7 2.0 -1.3 -0.1 -0.0 1.4 -0.2
Medication: Atorvastatin 0.4 0.5 1.2 -1.1 0.6 0.8 -0.6 -0.1
Illnesses of father: High blood pressure 2.0 2.5 5.5 -1.7 -1.4 1.0 2.4 -1.1
Alcohol drinker status: Never 0.8 1.0 2.6 -0.6 0.6 0.8 1.6 -0.9
Ever smoked 1.4 2.5 5.4 -1.9 0.0 2.3 0.8 -1.8
Basal metabolic rate 0.2 1.0 1.4 -1.2 -1.1 1.2 -0.6 -0.9
Leg fat percentage (left) 0.4 1.4 5.5 0.6 -0.5 0.8 -0.1 -2.4
Arm fat-free mass (left) 0.1 0.7 1.3 -0.7 -1.1 0.1 -1.0 -0.7
Number of operations (self-reported) 0.5 0.8 2.2 0.9 -0.6 0.2 -1.5 0.7
Average weekly beer plus cider intake 1.6 2.4 7.0 2.7 1.0 0.9 -1.0 1.4
Irritability 1.1 1.9 5.5 0.2 1.0 2.4 1.5 0.9
Risk taking 1.2 1.7 3.6 -1.3 -1.7 -1.9 0.6 0.2
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.5 -0.7 -0.6 -1.6 0.9 0.1
Fractured/broken bones in last 5 years 0.8 1.0 2.5 -0.7 -0.7 0.4 -1.1 1.6
Age started oral contraceptive pill 0.4 0.4 0.7 0.7 0.5 -0.8 -0.5 -0.6
Diastolic blood pressure, automated reading 0.3 1.0 2.8 1.4 0.3 -1.7 -0.1 -0.6
Ever depressed for a whole week 0.8 1.0 2.5 0.1 -1.6 -0.7 -0.1 1.3
Unable to work because of sickness or disability 1.0 1.3 4.0 1.1 0.0 2.0 -0.4 1.1
Commuting to job workplace: Cycle 2.9 3.5 9.1 -3.0 -0.6 0.2 2.5 -1.3
Myopia 1.0 1.4 2.9 -1.7 0.9 1.5 1.0 0.1
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.8 -0.5 0.6 0.1 2.0 -1.0
Cholesterol lowering medication 0.6 0.9 1.8 -0.1 0.5 1.2 -0.8 1.3
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 7.0 0.7 -1.5 0.1 -2.6 -0.4
Pain experienced in last month 1.0 1.6 2.9 -1.3 -1.1 -1.4 -1.7 -0.7
Supplements: Calcium 0.4 0.4 1.2 0.0 -1.1 -0.5 0.7 -0.0
Basal cell carcinoma (self-reported) 0.2 0.3 0.7 -0.6 0.5 0.2 -0.3 -0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.2 1.1 -0.9 -1.0 -0.5 0.6
Deep venous thrombosis (DVT) (self-reported) 2.2 2.8 5.5 1.4 0.4 -1.7 -1.9 2.3
Heart disease (siblings) 0.1 0.1 0.3 -0.2 0.0 0.5 0.6 0.2
Alcohol drinker status: Previous 0.6 0.7 2.8 -0.5 -0.5 1.7 0.4 -0.3
Pack years of smoking 2.1 3.1 8.7 2.5 0.2 0.1 -0.6 2.9
Impedance of whole body 0.2 0.8 1.6 1.3 0.7 -0.4 1.1 0.8
Leg fat mass (left) 0.4 1.5 5.3 0.1 -0.5 1.3 -0.1 -2.3
Arm predicted mass (left) 0.1 0.7 1.6 -0.9 -1.3 -0.2 -0.8 -0.7