Hub : Genes

EHD3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1610 0.0390 3.3e-07 0.087 0.081 0.107 0.109 0.091 1.0e-10 4.0e-10 6.1e-13 3.7e-13 3.9e-11
2 GTEx Cells Transformed fibroblasts 0.0920 0.0410 8.9e-03 0.010 NA 0.012 NA 0.008 5.5e-02 NA 4.0e-02 NA 7.2e-02
3 GTEx Esophagus Mucosa 0.3120 0.0580 2.1e-09 0.095 NA 0.182 NA 0.198 6.5e-07 NA 3.0e-12 NA 2.7e-13
4 GTEx Nerve Tibial 0.1632 0.0573 2.3e-03 0.068 NA 0.109 NA 0.086 1.5e-05 NA 4.3e-08 NA 1.1e-06
5 GTEx Pancreas 0.2920 0.0900 3.7e-03 -0.007 NA -0.005 NA -0.006 8.5e-01 NA 6.4e-01 NA 7.9e-01
6 YFS Blood 0.0256 0.0103 5.0e-03 -0.001 0.003 0.000 0.005 -0.001 9.8e-01 2.6e-02 5.0e-01 8.4e-03 8.2e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.7 1.7 0.7 -0.7 1.2 1.3 0.0 0.0
Bipolar Disorder or Schizophrenia 0.2 0.6 2.6 0.7 -0.0 0.7 1.6 0.0 -0.1
Depressed Affect (Nagel 2018) 0.4 0.9 1.9 -0.6 -1.1 0.0 1.4 0.0 -1.4
Depression (Nagel 2018) 0.3 0.4 1.1 -0.1 0.3 1.0 0.6 0.0 -0.9
Intelligence (Savage-Jansen 2018) 0.6 1.9 10.2 -1.0 -3.2 -0.3 -0.2 0.0 0.5
Neuroticism (Nagel 2018) 0.5 1.1 4.2 0.5 -1.2 0.1 0.7 0.0 -2.0
Schizophrenia (2018) 0.1 0.2 1.0 0.3 0.5 -0.1 1.0 0.0 -0.2
Schizophrenia vs Biploar Disorder 0.3 0.3 0.9 0.3 -0.8 0.9 0.6 0.0 0.1
Worry (Nagel 2018) 1.0 2.1 6.5 2.2 0.1 0.9 -0.6 0.0 -2.6
Alzheimer’s Disease (in mother) 0.8 0.9 3.5 -0.7 1.2 -0.0 -0.4 0.0 1.9
Alzheimer’s Disease (in father) 0.6 0.6 1.7 -0.7 0.4 0.3 1.1 0.0 1.3
Alzheimer’s Disease (including proxy) 1.0 1.4 4.2 -1.5 1.4 -0.1 0.1 0.0 2.1
Crohns Disease (2017) 0.2 0.5 2.4 -0.2 -0.1 -1.6 -0.7 0.0 0.4
Irritable Bowel Disease (IBD) 1.0 2.5 9.4 -0.4 -0.7 -3.1 -2.1 0.0 0.7
Ulcerative Colitis (UC) 1.3 2.5 7.7 -0.6 -0.5 -2.8 -2.5 0.0 0.6
Major Depression (MDD) 0.8 1.0 3.2 -1.2 0.9 -0.2 1.8 0.0 -0.4
Reaction Time 0.1 0.3 1.0 0.1 1.0 -0.6 -0.1 0.0 -0.5
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.3 -1.2 -1.5 -0.7 0.1 0.0 -0.3
Breast Cancer 0.1 0.3 1.5 -0.2 0.1 -0.4 -0.4 0.0 1.2
Ovarian Cancer 0.3 0.4 1.4 -0.8 -0.7 -0.4 1.2 0.0 -0.3
Prostate Cancer 0.7 1.0 2.8 0.4 1.7 1.3 0.5 0.0 0.9
Age at First Birth 1.2 1.8 5.0 0.9 -2.2 0.1 -2.2 0.0 -0.6
Bipolar Disorder (2011) 0.8 0.8 4.0 -0.1 -2.0 -0.1 -0.6 0.0 -0.4
Body Mass Index (BMI) (2010) 0.3 0.4 2.1 0.2 -1.5 0.5 -0.1 0.0 -0.1
Coronary Artery Disease (CAD) 0.6 0.7 1.5 -1.2 -0.3 -0.2 1.2 0.0 1.1
Crohns Disease (2012) 0.3 0.5 1.5 -0.7 -1.0 -1.2 -0.1 0.0 -0.3
Mean Putamen Volume 1.1 1.3 4.9 2.2 -1.0 -0.6 -0.9 0.0 -0.9
Fasting Glucose 0.8 0.9 3.0 -0.6 -0.0 1.4 1.7 0.0 -0.3
HbA1C 0.8 0.9 2.9 -0.9 1.7 -0.3 1.2 0.0 0.1
HDL Cholesterol 1.7 2.8 6.8 -1.7 1.6 1.2 2.6 0.0 1.8
LDL Cholesterol 0.8 1.3 2.8 0.6 1.4 -1.5 -1.7 0.0 -0.5
Lupus 0.3 0.5 1.2 -1.0 -0.1 0.8 1.1 0.0 -0.4
Neuroticism (2016) 0.3 0.5 1.9 0.1 -0.8 0.2 0.5 0.0 -1.4
Primary Biliary Cirrhosis 1.0 1.4 4.1 1.2 -2.0 -0.6 -0.9 0.0 -1.4
Rheumatoid Arthritis 0.3 0.4 2.3 0.4 1.5 -0.2 -0.1 0.0 0.4
Schizophrenia (2014) 0.1 0.2 0.8 0.7 0.1 0.1 0.9 0.0 -0.3
Triglycerides 0.8 1.4 3.1 1.2 -0.5 -1.6 -1.8 0.0 0.9
Type 2 Diabetes (T2D) (2012) 1.4 1.6 2.9 0.4 -1.6 -1.7 -1.3 0.0 1.5
Ulcerative Colitis 2.0 2.9 10.6 -1.6 -1.4 -3.3 -1.4 0.0 0.5
Blood Eosinophil Count 0.4 3.4 10.0 0.4 -0.3 3.2 2.1 0.0 -2.3
Blood Platelet Count 14.3 166.0 529.0 15.3 -1.3 23.0 12.2 0.0 -9.1
Blood Red Count 0.2 2.0 8.5 2.9 0.6 1.8 -0.2 0.0 0.1
Blood White Count 0.8 6.0 13.8 3.7 1.8 2.0 1.1 0.0 -3.7
Heel T-Score 0.1 0.4 1.7 -0.5 -0.2 -0.8 0.2 0.0 1.3
BMI 0.3 1.7 4.9 -1.8 0.1 -1.3 -0.4 0.0 -2.2
Height 0.1 1.4 6.3 -1.0 0.7 -0.7 -2.5 0.0 0.0
Waist Hip Ratio (WHR) 0.2 0.7 1.9 1.4 1.1 1.1 -0.0 0.0 0.1
Systolic Blood Pressure 0.2 1.1 2.5 1.6 -1.3 0.8 -0.6 0.0 1.1
Smoking Status 0.7 1.6 4.0 1.1 1.7 0.3 1.0 0.0 -2.0
Allergy or Eczema 0.2 0.5 1.5 -0.0 1.2 -0.7 -0.9 0.0 0.3
Cardiovascular Disease 0.3 0.9 2.3 -0.6 1.2 1.3 1.5 0.0 0.2
Hypothyroidism (self reported) 0.3 0.6 2.9 0.1 0.5 -0.1 -0.7 0.0 -1.7
Respiratory disease 1.1 2.5 6.3 -2.4 0.7 1.6 2.5 0.0 0.4
Type 2 Diabetes (T2D) (2018) 0.1 0.2 1.1 0.2 -0.1 0.3 1.1 0.0 -0.2
Lung FEV1/FVC ratio 0.5 2.5 7.2 0.5 1.4 -2.4 -2.7 0.0 0.3
Lung FVC 0.4 1.9 5.7 1.2 -1.6 0.4 -1.1 0.0 -2.4
Neuroticism 0.4 1.0 3.0 1.7 -0.0 0.4 0.5 0.0 -1.7
Chronotype (morning person) 0.1 0.3 1.4 -0.4 0.6 -0.1 -1.2 0.0 0.1
Hair Pigment 0.1 1.6 3.9 0.2 0.5 -1.9 -2.0 0.0 1.4
Tanning 0.0 0.4 1.9 -0.2 0.6 0.4 1.4 0.0 -0.1
Hand grip strength (left) 0.2 0.5 1.4 -0.5 -1.2 1.0 0.2 0.0 0.6
Number of treatments/medications taken 0.4 0.7 1.7 0.9 0.2 1.3 1.3 0.0 0.1
Average weekly spirits intake 0.4 0.5 1.0 0.9 1.0 -0.1 0.6 0.0 -0.9
Sensitivity / hurt feelings 0.7 1.3 3.0 1.3 -0.4 1.0 1.3 0.0 -1.7
Frequency of depressed mood in last 2 weeks 0.6 0.8 3.1 -0.1 1.2 0.5 0.2 0.0 -1.8
Hearing difficulty/problems: Yes 0.4 0.6 1.6 0.3 1.2 0.3 0.6 0.0 1.3
Relative age of first facial hair 0.6 1.2 2.8 -1.5 -1.7 -1.3 0.4 0.0 0.5
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.3 1.1 0.3 0.1 0.0 0.0 -1.1
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.7 0.6 -0.3 -0.8 -0.6 0.0 0.9
Ever had hysterectomy (womb removed) 0.8 0.9 4.0 -0.4 -0.9 -2.0 0.4 0.0 0.5
Systolic blood pressure, automated reading 0.3 0.8 3.1 1.1 -1.7 0.2 -0.8 0.0 0.2
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 4.2 0.6 -0.2 -1.5 -2.0 0.0 -0.9
Angina 0.7 0.9 2.8 1.7 -0.7 0.1 -1.3 0.0 -0.2
Medication for hormone replacement therapy 0.9 1.1 3.4 -0.5 1.8 -1.2 -0.6 0.0 1.0
Vitamin and mineral supplements 0.2 0.3 0.9 -0.9 -0.5 0.2 -0.6 0.0 -0.6
Supplements: Zinc 0.6 0.7 2.0 -0.8 1.1 1.4 0.5 0.0 -0.0
Medication: Co-codamol 0.4 0.4 1.9 -0.2 0.5 -0.6 -1.4 0.0 0.3
Medication: Metformin 0.6 0.8 3.2 -0.7 1.0 0.0 1.8 0.0 0.6
Diabetes (father) 0.9 1.1 3.2 -1.5 0.9 -0.5 1.8 0.0 0.5
Diabetes (mother) 2.6 3.3 12.9 -0.6 -0.8 -3.6 -2.4 0.0 0.6
Severe depression (siblings) 0.5 0.5 1.2 1.1 0.5 1.0 -0.4 0.0 -0.6
Pack years adult smoking proportion 0.8 1.2 2.7 1.5 0.8 1.6 0.9 0.0 -0.8
Impedance of leg (right) 0.2 1.1 3.9 2.0 0.3 -0.6 -0.1 0.0 1.5
Leg fat-free mass (left) 0.3 1.5 6.6 -2.6 0.5 -0.6 -0.2 0.0 -1.3
Trunk fat percentage 0.4 1.4 3.0 -0.9 0.6 -1.5 -1.5 0.0 -1.7
Hand grip strength (right) 0.5 1.4 5.3 0.2 -2.3 0.5 -1.1 0.0 1.1
Townsend deprivation index at recruitment 1.2 1.7 5.2 -0.7 1.3 0.6 1.5 0.0 -2.3
Current tobacco smoking 1.3 2.1 11.1 3.3 0.5 -0.4 -0.7 0.0 -0.7
Average weekly fortified wine intake 0.1 0.2 0.5 0.1 0.5 0.7 -0.3 0.0 -0.1
Maternal smoking around birth 0.6 0.9 2.7 0.2 1.6 -1.2 -1.1 0.0 0.2
Fed-up feelings 0.7 1.3 2.9 -1.7 0.2 -0.4 1.7 0.0 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 4.5 0.8 0.2 1.1 -0.2 0.0 -2.1
Relative age voice broke 1.5 2.2 5.0 -0.2 -1.9 -2.2 -2.2 0.0 0.2
Taking other prescription medications 0.7 1.1 2.6 0.7 0.3 1.6 0.9 0.0 -1.6
Age when periods started (menarche) 0.2 0.5 0.8 -0.5 0.9 -0.8 0.7 0.0 0.7
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 1.8 0.7 -0.5 -1.2 -1.4 0.0 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 3.5 -1.2 1.2 -1.9 -0.2 0.0 -0.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.2 0.9 -0.2 0.5 -1.1 0.0 -0.1
Qualifications: CSEs or equivalent 0.4 0.6 1.4 -0.7 1.2 0.9 -0.5 0.0 0.7
Serious illness, injury or assault to yourself 0.3 0.4 1.4 0.2 0.3 0.6 0.6 0.0 1.2
High blood pressure 0.3 1.0 2.5 -0.6 0.5 1.6 1.3 0.0 1.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.1 -0.6 1.1 -0.7 -0.2 0.0 0.4
Multivitamins +/- minerals 0.6 0.8 3.2 0.8 1.8 -0.8 0.3 0.0 0.0
Stomach or abdominal pain in last month 0.4 0.5 1.4 0.0 -0.9 1.2 0.9 0.0 -0.3
Supplements: Glucosamine 0.1 0.1 0.3 0.2 0.6 -0.3 0.1 0.0 -0.5
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 5.6 -2.4 -1.2 -0.8 0.9 0.0 0.5
Medication: Atenolol 0.9 1.1 2.5 1.6 -1.0 0.5 -0.6 0.0 1.6
Medication: Levothyroxine sodium 0.2 0.4 1.1 -0.3 -0.6 -0.8 -1.0 0.0 -0.5
Sitting height 0.3 1.9 8.0 -2.8 1.0 1.0 0.9 0.0 0.7
Chronic bronchitis/emphysema (father) 0.1 0.1 0.5 -0.0 0.7 -0.2 0.5 0.0 0.1
High blood pressure (mother) 0.4 0.5 1.9 0.4 0.0 0.3 1.4 0.0 0.9
Body mass index (BMI) 0.4 1.8 6.1 -2.0 0.2 -0.8 -0.3 0.0 -2.5
Impedance of leg (left) 0.2 1.1 4.7 2.2 0.5 0.2 -0.4 0.0 1.1
Leg predicted mass (left) 0.3 1.4 6.5 -2.5 0.4 -0.6 -0.1 0.0 -1.2
Trunk fat mass 0.4 1.6 3.4 -1.4 0.6 -1.4 -1.3 0.0 -1.9
Waist circumference 0.2 0.9 3.3 -1.3 0.1 -0.5 -0.2 0.0 -1.8
Number of incorrect matches in round 0.8 1.3 2.3 1.2 0.6 -1.2 -1.4 0.0 1.5
Past tobacco smoking 0.6 1.1 2.9 0.3 -1.1 -0.9 -1.3 0.0 1.7
Alcohol usually taken with meals 0.2 0.4 1.5 -0.9 -1.2 -0.2 -0.1 0.0 0.1
Nervous feelings 1.2 2.2 5.8 2.4 -1.6 -1.0 -1.5 0.0 -1.3
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.1 5.2 2.3 -0.3 1.8 0.1 0.0 -2.1
Hearing difficulty/problems with background noise 0.2 0.4 1.1 -1.1 0.5 0.1 1.0 0.0 0.1
Hair/balding pattern: Pattern 2 0.8 1.1 2.1 -1.4 1.2 0.6 1.2 0.0 -1.0
Had menopause 1.2 1.6 4.5 2.1 -1.4 -0.9 -1.3 0.0 0.5
Had other major operations 0.2 0.2 0.6 0.2 0.8 0.3 -0.7 0.0 -0.4
Forced vital capacity (FVC) 0.1 0.5 1.2 -0.8 0.4 1.1 -0.5 0.0 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 4.4 -0.6 0.5 -1.9 -2.1 0.0 -1.2
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.3 0.4 1.2 -0.1 -0.1 0.0 -0.3
Qualifications: None of the above 0.7 1.6 5.8 2.4 -0.6 -0.6 -1.4 0.0 -0.9
Financial difficulties in last 2 years 0.5 0.6 2.0 -0.5 0.3 0.7 0.9 0.0 -1.4
Mouth/teeth dental problems 0.1 0.2 0.8 -0.9 -0.5 0.0 0.3 0.0 0.4
Heart attack 0.2 0.3 1.0 -0.1 0.1 1.0 -0.5 0.0 -0.7
Allergy 0.1 0.3 0.6 0.7 -0.5 0.4 -0.3 0.0 -0.8
Pain all over the body in last month 0.2 0.2 0.9 0.2 0.6 -0.0 -0.5 0.0 -0.9
Diabetes (self-reported) 0.1 0.2 0.5 -0.4 0.1 -0.0 0.7 0.0 0.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.6 -0.7 -0.1 -0.8 -0.6 0.0 0.2
Medication: Ramipril 0.3 0.4 1.0 0.3 -0.8 1.0 0.4 0.0 0.6
Medication: Simvastatin 0.6 1.0 3.3 -1.1 1.1 0.3 1.8 0.0 0.0
Fluid intelligence score 0.3 0.7 2.9 -1.7 -0.7 -0.1 0.7 0.0 -0.1
Illnesses of siblings 0.2 0.3 1.2 -0.1 -0.1 0.6 0.5 0.0 -1.1
Neuroticism score 0.7 1.6 6.0 1.5 -0.9 0.6 0.1 0.0 -2.5
Weight 0.4 2.0 7.2 -2.7 0.5 -0.8 -0.5 0.0 -2.0
Impedance of arm (right) 0.1 0.7 3.0 1.7 0.7 0.4 -0.4 0.0 0.5
Arm fat percentage (right) 0.5 2.0 9.1 -0.8 0.5 -0.9 -1.1 0.0 -3.0
Trunk fat-free mass 0.3 1.5 6.5 -2.5 0.1 -0.2 -0.1 0.0 -1.5
Hip circumference 0.4 1.8 5.6 -2.4 -0.7 -0.7 0.2 0.0 -2.1
Time employed in main current job 0.5 0.5 1.4 1.2 -0.6 0.6 0.2 0.0 -1.0
Alcohol intake versus 10 years previously 0.5 0.7 2.5 0.1 1.6 0.6 0.9 0.0 -0.8
Father’s age at death 0.6 0.8 2.3 -0.6 -0.9 1.5 1.1 0.0 0.0
Worrier / anxious feelings 1.7 3.3 10.1 2.0 -0.3 2.2 0.5 0.0 -3.2
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.2 9.5 1.9 -0.7 2.3 0.1 0.0 -3.1
Falls in the last year 1.5 2.0 4.4 1.7 1.6 2.1 0.1 0.0 -1.4
Hair/balding pattern: Pattern 3 1.3 1.9 5.0 2.2 -2.2 0.4 -0.7 0.0 1.0
Number of live births 0.4 0.6 1.4 0.5 -0.9 1.1 0.3 0.0 -1.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.6 -0.8 0.7 0.2 -1.2 0.0 -0.8
Pulse rate 0.6 1.0 3.4 0.2 1.3 -1.8 -0.8 0.0 -0.3
Happiness 0.4 0.4 1.1 1.1 0.4 0.5 -0.8 0.0 -0.6
Noisy workplace 0.3 0.4 0.8 -0.9 0.3 -0.8 -0.2 0.0 -0.9
Qualifications: A levels/AS levels or equivalent 1.1 2.4 7.1 -2.2 0.1 -1.4 0.5 0.0 2.7
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 4.8 0.2 -2.2 -1.4 -1.1 0.0 0.9
Mouth/teeth dental problems: Dentures 0.3 0.6 2.9 1.7 -0.3 0.2 0.2 0.0 -0.5
Asthma 0.7 1.4 4.3 -1.3 -0.9 1.2 2.1 0.0 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.4 0.1 1.9 0.9 -0.2 0.0 -1.4
Medication: Cholesterol lowering 0.5 0.8 1.6 -0.8 0.3 -1.3 1.2 0.0 1.1
Depression (self-reported) 2.7 3.2 7.8 -1.1 1.2 2.4 2.8 0.0 -1.7
Medication: Lansoprazole 0.3 0.3 1.0 1.0 -0.9 0.0 -0.3 0.0 0.3
Prospective memory result 0.6 0.7 2.2 1.5 -0.3 1.2 -0.2 0.0 0.7
Lung cancer (father) 2.5 2.9 7.8 1.3 -1.5 -2.1 -2.8 0.0 -1.2
Illnesses of mother 1.4 1.8 3.6 1.9 1.5 0.4 -1.5 0.0 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 3.9 -0.5 1.4 0.1 -2.0 0.0 -1.0
Pulse wave Arterial Stiffness index 0.8 0.9 2.0 1.4 -0.2 -1.1 -1.2 0.0 0.7
Impedance of arm (left) 0.2 1.0 3.0 1.7 0.1 -0.4 -0.7 0.0 1.4
Arm fat mass (right) 0.6 2.3 7.5 -1.8 0.6 -1.3 -1.1 0.0 -2.7
Trunk predicted mass 0.3 1.5 6.4 -2.5 0.1 -0.3 -0.1 0.0 -1.6
Standing height 0.1 1.0 3.6 -1.9 0.9 -0.1 -0.6 0.0 1.0
Length of working week for main job 0.9 1.0 2.8 -0.5 -1.5 -1.7 -0.5 0.0 0.7
Exposure to tobacco smoke at home 0.5 0.6 1.7 1.3 -0.1 0.5 -0.9 0.0 -0.8
Breastfed as a baby 0.6 0.7 1.3 -1.2 -0.8 0.9 0.7 0.0 -1.0
Tense / ‘highly strung’ 1.4 2.3 8.3 1.6 -1.3 1.2 0.3 0.0 -2.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.6 1.1 0.8 0.4 1.3 0.0 -0.7
Hair/balding pattern: Pattern 4 0.4 0.9 2.8 0.3 -1.7 -1.4 -0.6 0.0 -0.2
Birth weight of first child 0.6 1.0 3.1 0.9 -0.1 -0.4 -1.5 0.0 -1.8
Peak expiratory flow (PEF) 0.9 2.1 6.9 -2.6 1.8 0.7 1.4 0.0 0.2
Pulse wave reflection index 1.5 1.8 4.4 1.9 -1.7 0.1 -2.1 0.0 0.1
Ever highly irritable/argumentative for 2 days 0.8 1.0 3.3 0.4 0.6 -1.8 -1.3 0.0 -0.7
Loud music exposure frequency 0.7 0.8 1.9 1.4 0.8 1.1 0.6 0.0 -0.8
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 3.5 -1.7 -0.6 -0.8 0.3 0.0 1.9
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.8 1.1 0.8 -0.5 -1.3 0.0 1.1
Blood clot in the leg (DVT) 0.2 0.3 1.0 -0.7 0.2 0.1 0.2 0.0 1.0
Medication: Paracetamol 0.2 0.4 1.3 1.1 0.4 0.6 -0.6 0.0 0.3
Headache pain in last month 0.5 0.8 2.5 1.4 0.2 -0.1 -0.7 0.0 -1.6
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 4.1 0.9 0.3 0.5 -2.0 0.0 -1.8
Glaucoma (self-reported) 1.2 1.4 4.4 2.1 0.8 0.3 -1.2 0.0 -1.4
Gout (self-reported) 0.7 0.9 2.1 1.4 -0.8 -0.2 -1.4 0.0 0.7
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.7 -0.6 0.2 -0.3 -0.5 0.0 -0.8
Medication: Amlodipine 0.5 0.7 2.7 1.1 0.3 1.6 -0.1 0.0 0.6
Medication: Ventolin 100micrograms inhaler 1.0 1.2 3.9 -1.3 0.5 1.2 2.0 0.0 0.2
Birth weight 0.3 0.8 2.7 -0.1 -0.3 -0.5 -1.2 0.0 -1.6
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.4 -0.5 -1.6 -0.6 1.0 0.0 -1.2
High blood pressure (siblings) 0.2 0.3 0.8 0.1 0.8 -0.1 -0.9 0.0 0.1
Forced vital capacity (FVC), Best measure 0.2 0.8 1.4 -0.6 1.2 0.9 -1.1 0.0 -1.0
Body fat percentage 0.3 1.4 4.0 -0.7 0.4 -1.3 -1.3 0.0 -2.0
Leg fat percentage (right) 0.3 1.0 3.4 -0.7 0.2 -1.4 -0.6 0.0 -1.9
Arm fat-free mass (right) 0.2 1.3 5.2 -2.3 -0.1 -1.0 -0.6 0.0 -1.0
Exposure to tobacco smoke outside home 1.7 2.2 7.7 -0.1 2.1 2.8 1.0 0.0 0.6
Comparative body size at age 10 0.7 1.9 5.3 -0.5 -2.3 -1.5 -1.2 0.0 -1.4
Number of full brothers 0.1 0.2 0.8 -0.1 0.9 -0.4 -0.1 0.0 0.0
Worry too long after embarrassment 0.5 0.8 2.2 -0.5 -1.5 -1.2 0.2 0.0 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 2.9 -0.3 1.7 0.2 1.7 0.0 -0.9
Wheeze or whistling in the chest in last year 1.0 1.8 6.7 -0.2 1.1 1.7 2.6 0.0 -0.5
Number of children fathered 0.6 0.7 1.9 -0.5 1.4 -0.5 1.2 0.0 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.7 -0.8 0.8 -0.1 0.1 0.0 -1.6
Age at first live birth 0.4 0.7 1.9 -0.3 -1.4 -0.4 -0.8 0.0 1.1
Pulse wave peak to peak time 0.9 1.1 2.7 -1.7 0.4 1.2 1.3 0.0 -0.7
Health satisfaction 0.4 0.5 1.3 0.5 0.7 0.9 -0.1 0.0 -1.2
Shortness of breath walking on level ground 0.2 0.2 0.5 0.0 0.7 0.5 0.1 0.0 0.6
Qualifications: College or University degree 0.1 0.4 2.2 -0.3 -0.5 0.3 0.1 0.0 1.5
Eye problems/disorders: None of the above 0.5 0.5 1.5 -1.1 1.2 -0.5 -0.2 0.0 -0.6
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.9 -0.6 0.9 -0.4 -0.1 0.0 0.0
Emphysema/chronic bronchitis 0.7 0.8 2.3 0.2 1.2 1.5 0.7 0.0 -0.6
Medication for pain relief, constipation, heartburn 1.0 1.8 4.0 -1.5 -1.0 -1.8 0.1 0.0 2.0
Neck or shoulder pain in last month 0.1 0.2 0.8 0.5 0.0 0.9 0.2 0.0 -0.1
Medication: Blood pressure 0.5 0.8 3.7 -0.1 -0.0 0.6 1.9 0.0 0.9
Angina (self-reported) 0.7 1.0 3.3 1.8 -0.8 0.3 -1.3 0.0 -0.2
Migraine (self-reported) 0.3 0.4 1.2 0.8 -1.1 -0.5 0.6 0.0 -0.1
Medication: Ibuprofen 1.1 1.4 3.4 0.2 1.2 1.8 0.5 0.0 -1.8
Medication: Allopurinol 1.6 2.2 6.5 2.3 -0.6 -0.7 -2.5 0.0 0.6
Medication: Omeprazole 1.9 2.2 6.1 -0.5 1.2 1.5 1.8 0.0 -2.5
Medication: Seretide 50 evohaler 1.2 1.4 7.6 0.3 -0.4 -0.5 0.1 0.0 2.8
Mean time to correctly identify matches 0.2 0.3 0.9 0.4 0.6 -0.7 -0.3 0.0 -1.0
Heart disease (mother) 0.2 0.2 1.2 -1.1 0.0 0.2 -0.2 0.0 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 4.7 2.2 0.7 1.6 0.5 0.0 -0.0
Whole body fat mass 0.4 1.7 3.8 -1.6 0.6 -1.5 -1.1 0.0 -2.0
Leg fat mass (right) 0.4 1.6 5.2 -1.4 0.3 -1.3 -0.7 0.0 -2.3
Arm predicted mass (right) 0.2 1.1 5.4 -2.3 -0.3 -0.7 -0.2 0.0 -0.9
Pulse rate, automated reading 0.3 1.0 3.2 0.5 1.8 -1.5 -0.3 0.0 -0.5
Alcohol intake frequency. 0.4 0.8 3.8 0.5 -0.1 0.5 0.8 0.0 -1.9
Comparative height size at age 10 0.1 0.6 2.0 -0.6 -1.4 -0.0 -0.7 0.0 0.9
Number of full sisters 0.5 0.6 1.4 0.7 1.2 1.1 0.6 0.0 -0.6
Suffer from ‘nerves’ 0.5 0.7 2.3 1.5 1.0 0.3 0.0 0.0 -1.0
Overall health rating 0.6 1.3 3.8 2.0 -0.2 1.0 -0.6 0.0 -1.7
Chest pain or discomfort 0.6 0.9 3.7 0.4 -0.5 1.0 -0.4 0.0 -1.9
Had major operations 0.5 0.6 1.1 0.5 0.4 1.1 1.0 0.0 -1.0
Age at last live birth 0.2 0.3 1.2 -0.3 -0.4 1.1 -0.2 0.0 0.3
Family relationship satisfaction 0.8 0.9 2.5 0.4 1.5 -0.5 -1.6 0.0 -0.5
Leg pain on walking 0.7 0.9 4.0 -1.0 0.0 -0.3 0.3 0.0 -2.0
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 3.6 -1.9 -0.8 -1.0 0.6 0.0 0.3
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.7 0.3 -0.4 -0.1 -0.8 0.0 1.3
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.7 -0.3 0.4 -0.8 -0.7 0.0 -0.5
Medication: Aspirin 1.2 1.6 5.4 2.3 -0.8 1.0 -0.6 0.0 -1.5
Supplements: Vitamin C 1.3 1.6 4.7 1.8 -0.7 2.2 1.1 0.0 0.1
Knee pain experienced in last month 0.7 1.0 3.3 1.8 -0.5 1.2 0.4 0.0 -1.0
Hypertension (Self-reported) 0.3 0.9 3.8 0.1 0.5 2.0 0.9 0.0 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.8 0.9 0.1 0.7 0.5 0.0 -1.7
Illnesses of father: Heart disease 0.2 0.3 1.1 1.1 -0.2 -0.7 -0.3 0.0 0.4
Illnesses of siblings: Diabetes 0.8 1.0 4.5 0.6 1.0 -0.4 0.0 0.0 2.1
Smoking status: Previous 0.9 1.4 2.5 -1.4 1.0 1.0 1.4 0.0 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.9 -0.9 1.7 0.8 -1.0 0.0 0.1
Whole body fat-free mass 0.2 1.4 6.0 -2.4 0.2 -0.2 -0.2 0.0 -1.4
Leg fat-free mass (right) 0.3 1.5 7.2 -2.7 0.6 -0.1 -0.2 0.0 -1.2
Arm fat percentage (left) 0.4 1.7 5.9 -1.0 0.3 -1.3 -1.1 0.0 -2.4
Average weekly red wine intake 0.6 0.9 2.1 -1.4 -0.9 -1.2 -1.0 0.0 0.5
Handedness (chirality/laterality): Left-handed 1.2 1.5 4.6 0.8 0.3 -1.9 -2.1 0.0 -0.2
Mood swings 0.6 1.2 3.6 -1.1 -0.2 -0.2 1.4 0.0 -1.9
Loneliness, isolation 0.9 1.3 5.1 0.9 0.3 -0.8 -1.0 0.0 -2.2
Long-standing illness, disability or infirmity 0.7 1.1 2.4 1.0 -1.6 1.2 1.1 0.0 -0.8
Ever had bowel cancer screening 1.2 1.4 2.9 1.2 -1.7 -0.1 -1.6 0.0 1.1
Diabetes diagnosed by doctor 0.3 0.4 0.7 -0.7 0.8 -0.4 0.8 0.0 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.5 0.3 0.0 -0.5 0.4 0.0 -0.7
Friendships satisfaction 0.6 0.8 3.6 -0.4 1.9 0.9 -0.2 0.0 -0.3
Qualifications: nursing, teaching 0.3 0.4 2.0 -1.4 0.2 -0.5 0.6 0.0 0.1
Commuting to job workplace: Walk 0.2 0.2 0.7 0.8 -0.0 -0.6 -0.2 0.0 0.0
Eye problems/disorders: Cataract 0.6 0.7 2.4 -0.3 -1.6 -0.4 -0.1 0.0 1.2
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.6 -1.6 1.6 -0.3 0.8 0.0 -0.2
Medication for cholesterol 0.5 0.7 1.5 -1.1 -1.0 -0.7 1.2 0.0 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.0 1.1 -0.1 0.4 -0.9 0.0 -1.4
Back pain experienced in last month 0.7 1.0 2.9 0.8 0.2 1.5 0.6 0.0 -1.7
Mineral and other dietary supplements 0.4 0.6 1.7 0.3 -0.4 0.9 -1.3 0.0 -0.9
Breast cancer (self-reported) 0.8 1.0 2.6 -0.3 1.6 0.5 1.1 0.0 1.2
Asthma (self-reported) 0.8 1.5 4.5 -1.4 -0.9 1.4 2.1 0.0 0.4
Osteoporosis (self-reported) 1.7 2.1 5.9 2.4 -1.8 0.6 -0.8 0.0 -1.5
Osteoarthritis (self-reported) 0.2 0.2 0.4 -0.7 0.6 -0.1 0.5 0.0 -0.5
Medication: Aspirin 1.1 1.4 5.1 2.3 -0.4 1.3 -0.1 0.0 -1.1
Medication: Gliclazide 1.3 1.4 5.0 -1.3 0.9 1.0 2.2 0.0 -0.5
Illnesses of father: None of the above (group 1) 0.7 0.9 2.6 -1.6 1.3 -0.3 -0.7 0.0 -0.5
Smoking status: Current 1.2 1.8 9.2 3.0 0.4 -0.6 -0.7 0.0 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 5.9 1.1 -1.5 -2.1 -2.4 0.0 -1.2
Whole body water mass 0.3 1.5 6.2 -2.5 0.2 -0.5 -0.4 0.0 -1.5
Leg predicted mass (right) 0.3 1.5 7.0 -2.6 0.5 -0.2 -0.3 0.0 -1.2
Arm fat mass (left) 0.5 2.0 6.1 -1.8 0.3 -1.3 -1.1 0.0 -2.5
Number of self-reported non-cancer illnesses 0.5 0.8 1.6 -0.2 -0.8 1.2 1.2 0.0 -1.2
Average weekly champagne plus white wine intake 0.8 1.1 4.0 1.4 0.2 -0.0 -1.0 0.0 2.0
Miserableness 0.4 0.7 2.4 -0.7 -0.3 -0.9 0.5 0.0 -1.6
Guilty feelings 0.3 0.5 1.7 0.2 -1.3 0.7 0.5 0.0 -0.5
Wears glasses or contact lenses 0.6 0.7 2.2 -0.2 -1.5 -0.6 1.0 0.0 -0.5
Ever taken oral contraceptive pill 0.4 0.5 1.3 -0.3 1.1 -0.6 0.4 0.0 1.0
Hearing aid user 0.7 0.8 2.1 0.8 -0.7 1.4 0.2 0.0 -1.2
Mother’s age at death 1.5 1.9 6.2 1.2 -1.4 -1.3 -2.5 0.0 0.3
Financial situation satisfaction 0.4 0.5 1.5 -1.1 1.2 0.2 0.3 0.0 -0.0
Tinnitus: Yes, now most or all of the time 0.5 0.5 2.0 1.4 0.5 0.8 0.6 0.0 -0.0
Commuting to job workplace: Public transport 0.8 1.0 2.3 -1.2 0.5 0.3 1.4 0.0 -1.5
Eye problems/disorders: Glaucoma 0.8 0.9 3.7 1.9 0.6 -0.1 -0.6 0.0 -1.1
Medication: Blood pressure 0.7 1.4 4.1 1.7 0.2 2.0 -1.1 0.0 -0.2
Pain type(s) experienced in last month: Hip pain 0.9 1.1 2.7 -0.7 1.1 1.4 0.7 0.0 -1.6
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.2 0.2 -0.1 -1.5 -0.3 0.0 0.9
High cholesterol (Self-reported) 0.2 0.4 1.1 -0.7 1.1 -0.9 0.1 0.0 0.4
Medication: Bendroflumethiazide 0.5 0.8 2.2 0.7 0.1 1.5 0.1 0.0 1.4
Medication: Paracetamol 0.6 1.0 3.9 2.0 -0.2 1.2 -0.7 0.0 0.1
Medication: Lisinopril 0.7 0.8 1.7 -0.5 1.0 1.3 0.8 0.0 1.2
Medication: Atorvastatin 0.7 0.9 2.3 1.1 -1.5 -0.8 -1.1 0.0 -0.2
Illnesses of father: High blood pressure 0.6 0.8 3.0 -0.0 -0.2 1.7 1.2 0.0 -0.5
Alcohol drinker status: Never 0.9 1.1 3.1 1.8 -1.8 -0.5 -0.4 0.0 -0.0
Ever smoked 0.5 1.0 3.7 0.7 1.9 0.5 0.9 0.0 -0.7
Basal metabolic rate 0.3 1.7 6.8 -2.6 0.3 -0.5 -0.3 0.0 -1.8
Leg fat percentage (left) 0.3 1.0 4.2 -0.6 0.4 -0.9 -0.5 0.0 -2.0
Arm fat-free mass (left) 0.2 1.1 3.5 -1.9 0.1 -0.1 -0.3 0.0 -1.7
Number of operations (self-reported) 0.3 0.5 1.2 -0.7 1.1 -1.1 -0.3 0.0 -0.0
Average weekly beer plus cider intake 0.3 0.5 1.7 1.3 -0.7 0.1 -0.8 0.0 0.2
Irritability 0.1 0.2 0.9 -0.2 0.1 -0.4 0.7 0.0 -0.9
Risk taking 0.5 0.7 1.5 0.7 1.2 0.6 1.2 0.0 -0.9
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.5 -0.8 0.5 -1.2 1.0 0.0 -1.0
Fractured/broken bones in last 5 years 1.5 2.0 4.8 2.0 -2.2 0.4 -1.3 0.0 1.1
Age started oral contraceptive pill 1.1 1.4 4.2 2.0 -1.3 1.5 -0.5 0.0 -0.2
Diastolic blood pressure, automated reading 0.2 0.6 2.3 0.3 -1.5 0.8 -0.2 0.0 -0.5
Ever depressed for a whole week 0.6 0.8 2.1 -0.4 0.7 0.8 1.1 0.0 1.4
Unable to work because of sickness or disability 0.3 0.4 1.1 1.1 0.0 1.0 0.3 0.0 -0.6
Commuting to job workplace: Cycle 0.9 1.1 4.0 0.5 1.3 0.8 0.6 0.0 2.0
Myopia 0.7 1.0 1.8 -1.3 1.4 -0.8 -0.3 0.0 1.3
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.3 0.2 -0.4 -1.1 -0.9 0.0 -0.8
Cholesterol lowering medication 0.6 0.9 2.2 1.0 1.1 1.5 -0.2 0.0 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 5.7 0.5 0.8 1.8 1.8 0.0 -2.4
Pain experienced in last month 0.7 1.2 3.3 -1.8 -0.6 -1.6 0.1 0.0 1.1
Supplements: Calcium 0.7 0.7 1.4 1.1 -0.7 1.2 -0.1 0.0 -1.1
Basal cell carcinoma (self-reported) 1.7 2.0 8.2 0.8 0.8 -1.5 -2.9 0.0 0.5
Heart attack/myocardial infarction (self-reported) 0.2 0.3 1.7 0.1 0.1 1.3 -0.2 0.0 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.4 -0.9 0.3 0.1 0.4 0.0 1.2
Heart disease (siblings) 0.1 0.1 0.2 -0.4 -0.2 -0.5 0.3 0.0 -0.3
Alcohol drinker status: Previous 0.3 0.4 0.9 0.7 0.9 0.5 -0.6 0.0 -0.3
Pack years of smoking 0.8 1.2 3.0 1.2 0.9 1.7 0.9 0.0 -1.1
Impedance of whole body 0.2 1.2 4.0 2.0 0.5 0.2 -0.5 0.0 1.6
Leg fat mass (left) 0.4 1.5 5.3 -1.5 0.4 -1.0 -0.6 0.0 -2.3
Arm predicted mass (left) 0.2 1.2 4.1 -2.0 0.3 -0.3 -0.5 0.0 -1.7