TWAS hub - EHD3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1610	0.0390	3.3e-07	0.087	0.081	0.107	0.109	0.091	1.0e-10	4.0e-10	6.1e-13	3.7e-13	3.9e-11
2	GTEx	Cells Transformed fibroblasts	0.0920	0.0410	8.9e-03	0.010	NA	0.012	NA	0.008	5.5e-02	NA	4.0e-02	NA	7.2e-02
3	GTEx	Esophagus Mucosa	0.3120	0.0580	2.1e-09	0.095	NA	0.182	NA	0.198	6.5e-07	NA	3.0e-12	NA	2.7e-13
4	GTEx	Nerve Tibial	0.1632	0.0573	2.3e-03	0.068	NA	0.109	NA	0.086	1.5e-05	NA	4.3e-08	NA	1.1e-06
5	GTEx	Pancreas	0.2920	0.0900	3.7e-03	-0.007	NA	-0.005	NA	-0.006	8.5e-01	NA	6.4e-01	NA	7.9e-01
6	YFS	Blood	0.0256	0.0103	5.0e-03	-0.001	0.003	0.000	0.005	-0.001	9.8e-01	2.6e-02	5.0e-01	8.4e-03	8.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	6
Blood Platelet Count	14.3	166.0	529.0	15.3	-1.3	23.0	12.2	-9.1
Depression (self-reported)	2.7	3.2	7.8	-1.1	1.2	2.4	2.8	-1.7
Diabetes (mother)	2.6	3.3	12.9	-0.6	-0.8	-3.6	-2.4	0.6
Lung cancer (father)	2.5	2.9	7.8	1.3	-1.5	-2.1	-2.8	-1.2
Ulcerative Colitis	2.0	2.9	10.6	-1.6	-1.4	-3.3	-1.4	0.5
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	9.5	1.9	-0.7	2.3	0.1	-3.1
Medication: Omeprazole	1.9	2.2	6.1	-0.5	1.2	1.5	1.8	-2.5
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	5.7	0.5	0.8	1.8	1.8	-2.4
HDL Cholesterol	1.7	2.8	6.8	-1.7	1.6	1.2	2.6	1.8
Worrier / anxious feelings	1.7	3.3	10.1	2.0	-0.3	2.2	0.5	-3.2
Exposure to tobacco smoke outside home	1.7	2.2	7.7	-0.1	2.1	2.8	1.0	0.6
Osteoporosis (self-reported)	1.7	2.1	5.9	2.4	-1.8	0.6	-0.8	-1.5
Basal cell carcinoma (self-reported)	1.7	2.0	8.2	0.8	0.8	-1.5	-2.9	0.5
Medication: Allopurinol	1.6	2.2	6.5	2.3	-0.6	-0.7	-2.5	0.6
Relative age voice broke	1.5	2.2	5.0	-0.2	-1.9	-2.2	-2.2	0.2
Falls in the last year	1.5	2.0	4.4	1.7	1.6	2.1	0.1	-1.4
Pulse wave reflection index	1.5	1.8	4.4	1.9	-1.7	0.1	-2.1	0.1
Mother’s age at death	1.5	1.9	6.2	1.2	-1.4	-1.3	-2.5	0.3
Fractured/broken bones in last 5 years	1.5	2.0	4.8	2.0	-2.2	0.4	-1.3	1.1
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.9	0.4	-1.6	-1.7	-1.3	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	5.2	2.3	-0.3	1.8	0.1	-2.1
Illnesses of mother	1.4	1.8	3.6	1.9	1.5	0.4	-1.5	-1.5
Tense / ‘highly strung’	1.4	2.3	8.3	1.6	-1.3	1.2	0.3	-2.9
Ulcerative Colitis (UC)	1.3	2.5	7.7	-0.6	-0.5	-2.8	-2.5	0.6
Current tobacco smoking	1.3	2.1	11.1	3.3	0.5	-0.4	-0.7	-0.7
Hair/balding pattern: Pattern 3	1.3	1.9	5.0	2.2	-2.2	0.4	-0.7	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	4.8	0.2	-2.2	-1.4	-1.1	0.9
Supplements: Vitamin C	1.3	1.6	4.7	1.8	-0.7	2.2	1.1	0.1
Medication: Gliclazide	1.3	1.4	5.0	-1.3	0.9	1.0	2.2	-0.5
Age at First Birth	1.2	1.8	5.0	0.9	-2.2	0.1	-2.2	-0.6
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	4.2	0.6	-0.2	-1.5	-2.0	-0.9
Townsend deprivation index at recruitment	1.2	1.7	5.2	-0.7	1.3	0.6	1.5	-2.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	5.6	-2.4	-1.2	-0.8	0.9	0.5
Nervous feelings	1.2	2.2	5.8	2.4	-1.6	-1.0	-1.5	-1.3
Had menopause	1.2	1.6	4.5	2.1	-1.4	-0.9	-1.3	0.5
Glaucoma (self-reported)	1.2	1.4	4.4	2.1	0.8	0.3	-1.2	-1.4
Medication: Seretide 50 evohaler	1.2	1.4	7.6	0.3	-0.4	-0.5	0.1	2.8
Medication: Aspirin	1.2	1.6	5.4	2.3	-0.8	1.0	-0.6	-1.5
Handedness (chirality/laterality): Left-handed	1.2	1.5	4.6	0.8	0.3	-1.9	-2.1	-0.2
Ever had bowel cancer screening	1.2	1.4	2.9	1.2	-1.7	-0.1	-1.6	1.1
Smoking status: Current	1.2	1.8	9.2	3.0	0.4	-0.6	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	5.9	1.1	-1.5	-2.1	-2.4	-1.2
Mean Putamen Volume	1.1	1.3	4.9	2.2	-1.0	-0.6	-0.9	-0.9
Respiratory disease	1.1	2.5	6.3	-2.4	0.7	1.6	2.5	0.4
Qualifications: A levels/AS levels or equivalent	1.1	2.4	7.1	-2.2	0.1	-1.4	0.5	2.7
Medication: Ibuprofen	1.1	1.4	3.4	0.2	1.2	1.8	0.5	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.7	2.2	0.7	1.6	0.5	-0.0
Medication: Aspirin	1.1	1.4	5.1	2.3	-0.4	1.3	-0.1	-1.1
Age started oral contraceptive pill	1.1	1.4	4.2	2.0	-1.3	1.5	-0.5	-0.2
Worry (Nagel 2018)	1.0	2.1	6.5	2.2	0.1	0.9	-0.6	-2.6
Alzheimer’s Disease (including proxy)	1.0	1.4	4.2	-1.5	1.4	-0.1	0.1	2.1
Irritable Bowel Disease (IBD)	1.0	2.5	9.4	-0.4	-0.7	-3.1	-2.1	0.7
Primary Biliary Cirrhosis	1.0	1.4	4.1	1.2	-2.0	-0.6	-0.9	-1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.2	3.9	-1.3	0.5	1.2	2.0	0.2
Wheeze or whistling in the chest in last year	1.0	1.8	6.7	-0.2	1.1	1.7	2.6	-0.5
Medication for pain relief, constipation, heartburn	1.0	1.8	4.0	-1.5	-1.0	-1.8	0.1	2.0
Medication for hormone replacement therapy	0.9	1.1	3.4	-0.5	1.8	-1.2	-0.6	1.0
Diabetes (father)	0.9	1.1	3.2	-1.5	0.9	-0.5	1.8	0.5
Medication: Atenolol	0.9	1.1	2.5	1.6	-1.0	0.5	-0.6	1.6
Length of working week for main job	0.9	1.0	2.8	-0.5	-1.5	-1.7	-0.5	0.7
Peak expiratory flow (PEF)	0.9	2.1	6.9	-2.6	1.8	0.7	1.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	4.1	0.9	0.3	0.5	-2.0	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.9	-0.3	1.7	0.2	1.7	-0.9
Pulse wave peak to peak time	0.9	1.1	2.7	-1.7	0.4	1.2	1.3	-0.7
Smoking status: Previous	0.9	1.4	2.5	-1.4	1.0	1.0	1.4	-1.6
Loneliness, isolation	0.9	1.3	5.1	0.9	0.3	-0.8	-1.0	-2.2
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.7	-0.7	1.1	1.4	0.7	-1.6
Alcohol drinker status: Never	0.9	1.1	3.1	1.8	-1.8	-0.5	-0.4	-0.0
Commuting to job workplace: Cycle	0.9	1.1	4.0	0.5	1.3	0.8	0.6	2.0
Alzheimer’s Disease (in mother)	0.8	0.9	3.5	-0.7	1.2	-0.0	-0.4	1.9
Major Depression (MDD)	0.8	1.0	3.2	-1.2	0.9	-0.2	1.8	-0.4
Bipolar Disorder (2011)	0.8	0.8	4.0	-0.1	-2.0	-0.1	-0.6	-0.4
Fasting Glucose	0.8	0.9	3.0	-0.6	-0.0	1.4	1.7	-0.3
HbA1C	0.8	0.9	2.9	-0.9	1.7	-0.3	1.2	0.1
LDL Cholesterol	0.8	1.3	2.8	0.6	1.4	-1.5	-1.7	-0.5
Triglycerides	0.8	1.4	3.1	1.2	-0.5	-1.6	-1.8	0.9
Blood White Count	0.8	6.0	13.8	3.7	1.8	2.0	1.1	-3.7
Ever had hysterectomy (womb removed)	0.8	0.9	4.0	-0.4	-0.9	-2.0	0.4	0.5
Pack years adult smoking proportion	0.8	1.2	2.7	1.5	0.8	1.6	0.9	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	4.5	0.8	0.2	1.1	-0.2	-2.1
Number of incorrect matches in round	0.8	1.3	2.3	1.2	0.6	-1.2	-1.4	1.5
Hair/balding pattern: Pattern 2	0.8	1.1	2.1	-1.4	1.2	0.6	1.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.4	0.1	1.9	0.9	-0.2	-1.4
Pulse wave Arterial Stiffness index	0.8	0.9	2.0	1.4	-0.2	-1.1	-1.2	0.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.3	0.4	0.6	-1.8	-1.3	-0.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	3.5	-1.7	-0.6	-0.8	0.3	1.9
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.4	-0.5	-1.6	-0.6	1.0	-1.2
Family relationship satisfaction	0.8	0.9	2.5	0.4	1.5	-0.5	-1.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	3.6	-1.9	-0.8	-1.0	0.6	0.3
Illnesses of siblings: Diabetes	0.8	1.0	4.5	0.6	1.0	-0.4	0.0	2.1
Breast cancer (self-reported)	0.8	1.0	2.6	-0.3	1.6	0.5	1.1	1.2
Asthma (self-reported)	0.8	1.5	4.5	-1.4	-0.9	1.4	2.1	0.4
Average weekly champagne plus white wine intake	0.8	1.1	4.0	1.4	0.2	-0.0	-1.0	2.0
Commuting to job workplace: Public transport	0.8	1.0	2.3	-1.2	0.5	0.3	1.4	-1.5
Eye problems/disorders: Glaucoma	0.8	0.9	3.7	1.9	0.6	-0.1	-0.6	-1.1
Pack years of smoking	0.8	1.2	3.0	1.2	0.9	1.7	0.9	-1.1
Prostate Cancer	0.7	1.0	2.8	0.4	1.7	1.3	0.5	0.9
Smoking Status	0.7	1.6	4.0	1.1	1.7	0.3	1.0	-2.0
Sensitivity / hurt feelings	0.7	1.3	3.0	1.3	-0.4	1.0	1.3	-1.7
Angina	0.7	0.9	2.8	1.7	-0.7	0.1	-1.3	-0.2
Fed-up feelings	0.7	1.3	2.9	-1.7	0.2	-0.4	1.7	-1.4
Taking other prescription medications	0.7	1.1	2.6	0.7	0.3	1.6	0.9	-1.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	1.8	0.7	-0.5	-1.2	-1.4	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.4	-0.6	0.5	-1.9	-2.1	-1.2
Qualifications: None of the above	0.7	1.6	5.8	2.4	-0.6	-0.6	-1.4	-0.9
Neuroticism score	0.7	1.6	6.0	1.5	-0.9	0.6	0.1	-2.5
Asthma	0.7	1.4	4.3	-1.3	-0.9	1.2	2.1	0.3
Loud music exposure frequency	0.7	0.8	1.9	1.4	0.8	1.1	0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.8	1.1	0.8	-0.5	-1.3	1.1
Gout (self-reported)	0.7	0.9	2.1	1.4	-0.8	-0.2	-1.4	0.7
Comparative body size at age 10	0.7	1.9	5.3	-0.5	-2.3	-1.5	-1.2	-1.4
Emphysema/chronic bronchitis	0.7	0.8	2.3	0.2	1.2	1.5	0.7	-0.6
Angina (self-reported)	0.7	1.0	3.3	1.8	-0.8	0.3	-1.3	-0.2
Leg pain on walking	0.7	0.9	4.0	-1.0	0.0	-0.3	0.3	-2.0
Knee pain experienced in last month	0.7	1.0	3.3	1.8	-0.5	1.2	0.4	-1.0
Long-standing illness, disability or infirmity	0.7	1.1	2.4	1.0	-1.6	1.2	1.1	-0.8
Back pain experienced in last month	0.7	1.0	2.9	0.8	0.2	1.5	0.6	-1.7
Illnesses of father: None of the above (group 1)	0.7	0.9	2.6	-1.6	1.3	-0.3	-0.7	-0.5
Hearing aid user	0.7	0.8	2.1	0.8	-0.7	1.4	0.2	-1.2
Medication: Blood pressure	0.7	1.4	4.1	1.7	0.2	2.0	-1.1	-0.2
Medication: Lisinopril	0.7	0.8	1.7	-0.5	1.0	1.3	0.8	1.2
Medication: Atorvastatin	0.7	0.9	2.3	1.1	-1.5	-0.8	-1.1	-0.2
Myopia	0.7	1.0	1.8	-1.3	1.4	-0.8	-0.3	1.3
Pain experienced in last month	0.7	1.2	3.3	-1.8	-0.6	-1.6	0.1	1.1
Supplements: Calcium	0.7	0.7	1.4	1.1	-0.7	1.2	-0.1	-1.1
Intelligence (Savage-Jansen 2018)	0.6	1.9	10.2	-1.0	-3.2	-0.3	-0.2	0.5
Alzheimer’s Disease (in father)	0.6	0.6	1.7	-0.7	0.4	0.3	1.1	1.3
Coronary Artery Disease (CAD)	0.6	0.7	1.5	-1.2	-0.3	-0.2	1.2	1.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.1	-0.1	1.2	0.5	0.2	-1.8
Relative age of first facial hair	0.6	1.2	2.8	-1.5	-1.7	-1.3	0.4	0.5
Supplements: Zinc	0.6	0.7	2.0	-0.8	1.1	1.4	0.5	-0.0
Medication: Metformin	0.6	0.8	3.2	-0.7	1.0	0.0	1.8	0.6
Maternal smoking around birth	0.6	0.9	2.7	0.2	1.6	-1.2	-1.1	0.2
Multivitamins +/- minerals	0.6	0.8	3.2	0.8	1.8	-0.8	0.3	0.0
Past tobacco smoking	0.6	1.1	2.9	0.3	-1.1	-0.9	-1.3	1.7
Medication: Simvastatin	0.6	1.0	3.3	-1.1	1.1	0.3	1.8	0.0
Father’s age at death	0.6	0.8	2.3	-0.6	-0.9	1.5	1.1	0.0
Pulse rate	0.6	1.0	3.4	0.2	1.3	-1.8	-0.8	-0.3
Prospective memory result	0.6	0.7	2.2	1.5	-0.3	1.2	-0.2	0.7
Arm fat mass (right)	0.6	2.3	7.5	-1.8	0.6	-1.3	-1.1	-2.7
Breastfed as a baby	0.6	0.7	1.3	-1.2	-0.8	0.9	0.7	-1.0
Birth weight of first child	0.6	1.0	3.1	0.9	-0.1	-0.4	-1.5	-1.8
Number of children fathered	0.6	0.7	1.9	-0.5	1.4	-0.5	1.2	-0.1
Overall health rating	0.6	1.3	3.8	2.0	-0.2	1.0	-0.6	-1.7
Chest pain or discomfort	0.6	0.9	3.7	0.4	-0.5	1.0	-0.4	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.8	0.9	0.1	0.7	0.5	-1.7
Average weekly red wine intake	0.6	0.9	2.1	-1.4	-0.9	-1.2	-1.0	0.5
Mood swings	0.6	1.2	3.6	-1.1	-0.2	-0.2	1.4	-1.9
Friendships satisfaction	0.6	0.8	3.6	-0.4	1.9	0.9	-0.2	-0.3
Eye problems/disorders: Cataract	0.6	0.7	2.4	-0.3	-1.6	-0.4	-0.1	1.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.6	-1.6	1.6	-0.3	0.8	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.0	1.1	-0.1	0.4	-0.9	-1.4
Wears glasses or contact lenses	0.6	0.7	2.2	-0.2	-1.5	-0.6	1.0	-0.5
Medication: Paracetamol	0.6	1.0	3.9	2.0	-0.2	1.2	-0.7	0.1
Illnesses of father: High blood pressure	0.6	0.8	3.0	-0.0	-0.2	1.7	1.2	-0.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	-0.8	0.5	-1.2	1.0	-1.0
Ever depressed for a whole week	0.6	0.8	2.1	-0.4	0.7	0.8	1.1	1.4
Cholesterol lowering medication	0.6	0.9	2.2	1.0	1.1	1.5	-0.2	-1.0
Neuroticism (Nagel 2018)	0.5	1.1	4.2	0.5	-1.2	0.1	0.7	-2.0
Lung FEV1/FVC ratio	0.5	2.5	7.2	0.5	1.4	-2.4	-2.7	0.3
Severe depression (siblings)	0.5	0.5	1.2	1.1	0.5	1.0	-0.4	-0.6
Hand grip strength (right)	0.5	1.4	5.3	0.2	-2.3	0.5	-1.1	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.5	-1.2	1.2	-1.9	-0.2	-0.2
Financial difficulties in last 2 years	0.5	0.6	2.0	-0.5	0.3	0.7	0.9	-1.4
Arm fat percentage (right)	0.5	2.0	9.1	-0.8	0.5	-0.9	-1.1	-3.0
Time employed in main current job	0.5	0.5	1.4	1.2	-0.6	0.6	0.2	-1.0
Alcohol intake versus 10 years previously	0.5	0.7	2.5	0.1	1.6	0.6	0.9	-0.8
Medication: Cholesterol lowering	0.5	0.8	1.6	-0.8	0.3	-1.3	1.2	1.1
Exposure to tobacco smoke at home	0.5	0.6	1.7	1.3	-0.1	0.5	-0.9	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.6	1.1	0.8	0.4	1.3	-0.7
Headache pain in last month	0.5	0.8	2.5	1.4	0.2	-0.1	-0.7	-1.6
Medication: Amlodipine	0.5	0.7	2.7	1.1	0.3	1.6	-0.1	0.6
Worry too long after embarrassment	0.5	0.8	2.2	-0.5	-1.5	-1.2	0.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.7	-0.8	0.8	-0.1	0.1	-1.6
Eye problems/disorders: None of the above	0.5	0.5	1.5	-1.1	1.2	-0.5	-0.2	-0.6
Medication: Blood pressure	0.5	0.8	3.7	-0.1	-0.0	0.6	1.9	0.9
Number of full sisters	0.5	0.6	1.4	0.7	1.2	1.1	0.6	-0.6
Suffer from ‘nerves’	0.5	0.7	2.3	1.5	1.0	0.3	0.0	-1.0
Had major operations	0.5	0.6	1.1	0.5	0.4	1.1	1.0	-1.0
Medication for cholesterol	0.5	0.7	1.5	-1.1	-1.0	-0.7	1.2	0.0
Arm fat mass (left)	0.5	2.0	6.1	-1.8	0.3	-1.3	-1.1	-2.5
Number of self-reported non-cancer illnesses	0.5	0.8	1.6	-0.2	-0.8	1.2	1.2	-1.2
Tinnitus: Yes, now most or all of the time	0.5	0.5	2.0	1.4	0.5	0.8	0.6	-0.0
Medication: Bendroflumethiazide	0.5	0.8	2.2	0.7	0.1	1.5	0.1	1.4
Ever smoked	0.5	1.0	3.7	0.7	1.9	0.5	0.9	-0.7
Risk taking	0.5	0.7	1.5	0.7	1.2	0.6	1.2	-0.9
Bipolar Disorder (2018)	0.4	0.7	1.7	0.7	-0.7	1.2	1.3	0.0
Depressed Affect (Nagel 2018)	0.4	0.9	1.9	-0.6	-1.1	0.0	1.4	-1.4
Blood Eosinophil Count	0.4	3.4	10.0	0.4	-0.3	3.2	2.1	-2.3
Lung FVC	0.4	1.9	5.7	1.2	-1.6	0.4	-1.1	-2.4
Neuroticism	0.4	1.0	3.0	1.7	-0.0	0.4	0.5	-1.7
Number of treatments/medications taken	0.4	0.7	1.7	0.9	0.2	1.3	1.3	0.1
Average weekly spirits intake	0.4	0.5	1.0	0.9	1.0	-0.1	0.6	-0.9
Hearing difficulty/problems: Yes	0.4	0.6	1.6	0.3	1.2	0.3	0.6	1.3
Medication: Co-codamol	0.4	0.4	1.9	-0.2	0.5	-0.6	-1.4	0.3
Trunk fat percentage	0.4	1.4	3.0	-0.9	0.6	-1.5	-1.5	-1.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.9	-0.2	0.5	-1.1	-0.1
Qualifications: CSEs or equivalent	0.4	0.6	1.4	-0.7	1.2	0.9	-0.5	0.7
Stomach or abdominal pain in last month	0.4	0.5	1.4	0.0	-0.9	1.2	0.9	-0.3
High blood pressure (mother)	0.4	0.5	1.9	0.4	0.0	0.3	1.4	0.9
Body mass index (BMI)	0.4	1.8	6.1	-2.0	0.2	-0.8	-0.3	-2.5
Trunk fat mass	0.4	1.6	3.4	-1.4	0.6	-1.4	-1.3	-1.9
Weight	0.4	2.0	7.2	-2.7	0.5	-0.8	-0.5	-2.0
Hip circumference	0.4	1.8	5.6	-2.4	-0.7	-0.7	0.2	-2.1
Number of live births	0.4	0.6	1.4	0.5	-0.9	1.1	0.3	-1.2
Happiness	0.4	0.4	1.1	1.1	0.4	0.5	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.9	-0.5	1.4	0.1	-2.0	-1.0
Hair/balding pattern: Pattern 4	0.4	0.9	2.8	0.3	-1.7	-1.4	-0.6	-0.2
Age at first live birth	0.4	0.7	1.9	-0.3	-1.4	-0.4	-0.8	1.1
Health satisfaction	0.4	0.5	1.3	0.5	0.7	0.9	-0.1	-1.2
Whole body fat mass	0.4	1.7	3.8	-1.6	0.6	-1.5	-1.1	-2.0
Leg fat mass (right)	0.4	1.6	5.2	-1.4	0.3	-1.3	-0.7	-2.3
Alcohol intake frequency.	0.4	0.8	3.8	0.5	-0.1	0.5	0.8	-1.9
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.7	0.3	-0.4	-0.1	-0.8	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.9	-0.9	1.7	0.8	-1.0	0.1
Arm fat percentage (left)	0.4	1.7	5.9	-1.0	0.3	-1.3	-1.1	-2.4
Mineral and other dietary supplements	0.4	0.6	1.7	0.3	-0.4	0.9	-1.3	-0.9
Miserableness	0.4	0.7	2.4	-0.7	-0.3	-0.9	0.5	-1.6
Ever taken oral contraceptive pill	0.4	0.5	1.3	-0.3	1.1	-0.6	0.4	1.0
Financial situation satisfaction	0.4	0.5	1.5	-1.1	1.2	0.2	0.3	-0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.2	0.2	-0.1	-1.5	-0.3	0.9
Leg fat mass (left)	0.4	1.5	5.3	-1.5	0.4	-1.0	-0.6	-2.3
Depression (Nagel 2018)	0.3	0.4	1.1	-0.1	0.3	1.0	0.6	-0.9
Schizophrenia vs Biploar Disorder	0.3	0.3	0.9	0.3	-0.8	0.9	0.6	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.3	-1.2	-1.5	-0.7	0.1	-0.3
Ovarian Cancer	0.3	0.4	1.4	-0.8	-0.7	-0.4	1.2	-0.3
Body Mass Index (BMI) (2010)	0.3	0.4	2.1	0.2	-1.5	0.5	-0.1	-0.1
Crohns Disease (2012)	0.3	0.5	1.5	-0.7	-1.0	-1.2	-0.1	-0.3
Lupus	0.3	0.5	1.2	-1.0	-0.1	0.8	1.1	-0.4
Neuroticism (2016)	0.3	0.5	1.9	0.1	-0.8	0.2	0.5	-1.4
Rheumatoid Arthritis	0.3	0.4	2.3	0.4	1.5	-0.2	-0.1	0.4
BMI	0.3	1.7	4.9	-1.8	0.1	-1.3	-0.4	-2.2
Cardiovascular Disease	0.3	0.9	2.3	-0.6	1.2	1.3	1.5	0.2
Hypothyroidism (self reported)	0.3	0.6	2.9	0.1	0.5	-0.1	-0.7	-1.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	1.1	0.3	0.1	0.0	-1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	0.6	-0.3	-0.8	-0.6	0.9
Systolic blood pressure, automated reading	0.3	0.8	3.1	1.1	-1.7	0.2	-0.8	0.2
Leg fat-free mass (left)	0.3	1.5	6.6	-2.6	0.5	-0.6	-0.2	-1.3
Serious illness, injury or assault to yourself	0.3	0.4	1.4	0.2	0.3	0.6	0.6	1.2
High blood pressure	0.3	1.0	2.5	-0.6	0.5	1.6	1.3	1.0
Sitting height	0.3	1.9	8.0	-2.8	1.0	1.0	0.9	0.7
Leg predicted mass (left)	0.3	1.4	6.5	-2.5	0.4	-0.6	-0.1	-1.2
Medication: Ramipril	0.3	0.4	1.0	0.3	-0.8	1.0	0.4	0.6
Fluid intelligence score	0.3	0.7	2.9	-1.7	-0.7	-0.1	0.7	-0.1
Trunk fat-free mass	0.3	1.5	6.5	-2.5	0.1	-0.2	-0.1	-1.5
Noisy workplace	0.3	0.4	0.8	-0.9	0.3	-0.8	-0.2	-0.9
Mouth/teeth dental problems: Dentures	0.3	0.6	2.9	1.7	-0.3	0.2	0.2	-0.5
Medication: Lansoprazole	0.3	0.3	1.0	1.0	-0.9	0.0	-0.3	0.3
Trunk predicted mass	0.3	1.5	6.4	-2.5	0.1	-0.3	-0.1	-1.6
Birth weight	0.3	0.8	2.7	-0.1	-0.3	-0.5	-1.2	-1.6
Body fat percentage	0.3	1.4	4.0	-0.7	0.4	-1.3	-1.3	-2.0
Leg fat percentage (right)	0.3	1.0	3.4	-0.7	0.2	-1.4	-0.6	-1.9
Migraine (self-reported)	0.3	0.4	1.2	0.8	-1.1	-0.5	0.6	-0.1
Pulse rate, automated reading	0.3	1.0	3.2	0.5	1.8	-1.5	-0.3	-0.5
Hypertension (Self-reported)	0.3	0.9	3.8	0.1	0.5	2.0	0.9	0.6
Leg fat-free mass (right)	0.3	1.5	7.2	-2.7	0.6	-0.1	-0.2	-1.2
Diabetes diagnosed by doctor	0.3	0.4	0.7	-0.7	0.8	-0.4	0.8	0.8
Qualifications: nursing, teaching	0.3	0.4	2.0	-1.4	0.2	-0.5	0.6	0.1
Whole body water mass	0.3	1.5	6.2	-2.5	0.2	-0.5	-0.4	-1.5
Leg predicted mass (right)	0.3	1.5	7.0	-2.6	0.5	-0.2	-0.3	-1.2
Guilty feelings	0.3	0.5	1.7	0.2	-1.3	0.7	0.5	-0.5
Basal metabolic rate	0.3	1.7	6.8	-2.6	0.3	-0.5	-0.3	-1.8
Leg fat percentage (left)	0.3	1.0	4.2	-0.6	0.4	-0.9	-0.5	-2.0
Number of operations (self-reported)	0.3	0.5	1.2	-0.7	1.1	-1.1	-0.3	-0.0
Average weekly beer plus cider intake	0.3	0.5	1.7	1.3	-0.7	0.1	-0.8	0.2
Unable to work because of sickness or disability	0.3	0.4	1.1	1.1	0.0	1.0	0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.4	-0.9	0.3	0.1	0.4	1.2
Alcohol drinker status: Previous	0.3	0.4	0.9	0.7	0.9	0.5	-0.6	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.6	2.6	0.7	-0.0	0.7	1.6	-0.1
Crohns Disease (2017)	0.2	0.5	2.4	-0.2	-0.1	-1.6	-0.7	0.4
Blood Red Count	0.2	2.0	8.5	2.9	0.6	1.8	-0.2	0.1
Waist Hip Ratio (WHR)	0.2	0.7	1.9	1.4	1.1	1.1	-0.0	0.1
Systolic Blood Pressure	0.2	1.1	2.5	1.6	-1.3	0.8	-0.6	1.1
Allergy or Eczema	0.2	0.5	1.5	-0.0	1.2	-0.7	-0.9	0.3
Hand grip strength (left)	0.2	0.5	1.4	-0.5	-1.2	1.0	0.2	0.6
Vitamin and mineral supplements	0.2	0.3	0.9	-0.9	-0.5	0.2	-0.6	-0.6
Impedance of leg (right)	0.2	1.1	3.9	2.0	0.3	-0.6	-0.1	1.5
Age when periods started (menarche)	0.2	0.5	0.8	-0.5	0.9	-0.8	0.7	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-0.6	1.1	-0.7	-0.2	0.4
Medication: Levothyroxine sodium	0.2	0.4	1.1	-0.3	-0.6	-0.8	-1.0	-0.5
Impedance of leg (left)	0.2	1.1	4.7	2.2	0.5	0.2	-0.4	1.1
Waist circumference	0.2	0.9	3.3	-1.3	0.1	-0.5	-0.2	-1.8
Alcohol usually taken with meals	0.2	0.4	1.5	-0.9	-1.2	-0.2	-0.1	0.1
Hearing difficulty/problems with background noise	0.2	0.4	1.1	-1.1	0.5	0.1	1.0	0.1
Had other major operations	0.2	0.2	0.6	0.2	0.8	0.3	-0.7	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.3	0.4	1.2	-0.1	-0.1	-0.3
Heart attack	0.2	0.3	1.0	-0.1	0.1	1.0	-0.5	-0.7
Pain all over the body in last month	0.2	0.2	0.9	0.2	0.6	-0.0	-0.5	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	-0.7	-0.1	-0.8	-0.6	0.2
Illnesses of siblings	0.2	0.3	1.2	-0.1	-0.1	0.6	0.5	-1.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.6	-0.8	0.7	0.2	-1.2	-0.8
Impedance of arm (left)	0.2	1.0	3.0	1.7	0.1	-0.4	-0.7	1.4
Blood clot in the leg (DVT)	0.2	0.3	1.0	-0.7	0.2	0.1	0.2	1.0
Medication: Paracetamol	0.2	0.4	1.3	1.1	0.4	0.6	-0.6	0.3
High blood pressure (siblings)	0.2	0.3	0.8	0.1	0.8	-0.1	-0.9	0.1
Forced vital capacity (FVC), Best measure	0.2	0.8	1.4	-0.6	1.2	0.9	-1.1	-1.0
Arm fat-free mass (right)	0.2	1.3	5.2	-2.3	-0.1	-1.0	-0.6	-1.0
Shortness of breath walking on level ground	0.2	0.2	0.5	0.0	0.7	0.5	0.1	0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.9	-0.6	0.9	-0.4	-0.1	0.0
Mean time to correctly identify matches	0.2	0.3	0.9	0.4	0.6	-0.7	-0.3	-1.0
Heart disease (mother)	0.2	0.2	1.2	-1.1	0.0	0.2	-0.2	-0.3
Arm predicted mass (right)	0.2	1.1	5.4	-2.3	-0.3	-0.7	-0.2	-0.9
Age at last live birth	0.2	0.3	1.2	-0.3	-0.4	1.1	-0.2	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.3	0.4	-0.8	-0.7	-0.5
Illnesses of father: Heart disease	0.2	0.3	1.1	1.1	-0.2	-0.7	-0.3	0.4
Whole body fat-free mass	0.2	1.4	6.0	-2.4	0.2	-0.2	-0.2	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.3	0.0	-0.5	0.4	-0.7
Commuting to job workplace: Walk	0.2	0.2	0.7	0.8	-0.0	-0.6	-0.2	0.0
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.7	0.6	-0.1	0.5	-0.5
High cholesterol (Self-reported)	0.2	0.4	1.1	-0.7	1.1	-0.9	0.1	0.4
Arm fat-free mass (left)	0.2	1.1	3.5	-1.9	0.1	-0.1	-0.3	-1.7
Diastolic blood pressure, automated reading	0.2	0.6	2.3	0.3	-1.5	0.8	-0.2	-0.5
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.3	0.2	-0.4	-1.1	-0.9	-0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.7	0.1	0.1	1.3	-0.2	-0.4
Impedance of whole body	0.2	1.2	4.0	2.0	0.5	0.2	-0.5	1.6
Arm predicted mass (left)	0.2	1.2	4.1	-2.0	0.3	-0.3	-0.5	-1.7
Schizophrenia (2018)	0.1	0.2	1.0	0.3	0.5	-0.1	1.0	-0.2
Reaction Time	0.1	0.3	1.0	0.1	1.0	-0.6	-0.1	-0.5
Breast Cancer	0.1	0.3	1.5	-0.2	0.1	-0.4	-0.4	1.2
Schizophrenia (2014)	0.1	0.2	0.8	0.7	0.1	0.1	0.9	-0.3
Heel T-Score	0.1	0.4	1.7	-0.5	-0.2	-0.8	0.2	1.3
Height	0.1	1.4	6.3	-1.0	0.7	-0.7	-2.5	0.0
Type 2 Diabetes (T2D) (2018)	0.1	0.2	1.1	0.2	-0.1	0.3	1.1	-0.2
Chronotype (morning person)	0.1	0.3	1.4	-0.4	0.6	-0.1	-1.2	0.1
Hair Pigment	0.1	1.6	3.9	0.2	0.5	-1.9	-2.0	1.4
Average weekly fortified wine intake	0.1	0.2	0.5	0.1	0.5	0.7	-0.3	-0.1
Supplements: Glucosamine	0.1	0.1	0.3	0.2	0.6	-0.3	0.1	-0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.5	-0.0	0.7	-0.2	0.5	0.1
Forced vital capacity (FVC)	0.1	0.5	1.2	-0.8	0.4	1.1	-0.5	-0.9
Mouth/teeth dental problems	0.1	0.2	0.8	-0.9	-0.5	0.0	0.3	0.4
Allergy	0.1	0.3	0.6	0.7	-0.5	0.4	-0.3	-0.8
Diabetes (self-reported)	0.1	0.2	0.5	-0.4	0.1	-0.0	0.7	0.6
Impedance of arm (right)	0.1	0.7	3.0	1.7	0.7	0.4	-0.4	0.5
Standing height	0.1	1.0	3.6	-1.9	0.9	-0.1	-0.6	1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.7	-0.6	0.2	-0.3	-0.5	-0.8
Number of full brothers	0.1	0.2	0.8	-0.1	0.9	-0.4	-0.1	0.0
Qualifications: College or University degree	0.1	0.4	2.2	-0.3	-0.5	0.3	0.1	1.5
Neck or shoulder pain in last month	0.1	0.2	0.8	0.5	0.0	0.9	0.2	-0.1
Comparative height size at age 10	0.1	0.6	2.0	-0.6	-1.4	-0.0	-0.7	0.9
Irritability	0.1	0.2	0.9	-0.2	0.1	-0.4	0.7	-0.9
Heart disease (siblings)	0.1	0.1	0.2	-0.4	-0.2	-0.5	0.3	-0.3
Tanning	0.0	0.4	1.9	-0.2	0.6	0.4	1.4	-0.1

Hub : Genes

EHD3

Models

Trait associations