Hub : Genes

EIF3K

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1664	0.0699	0.00890	-0.008	NA	-0.008	NA	-0.008	0.990	NA	8.5e-01	NA	9.0e-01
2	GTEx	Colon Sigmoid	0.1570	0.0610	0.00290	0.003	NA	0.034	NA	0.010	0.250	NA	2.3e-02	NA	1.4e-01
3	YFS	Blood	0.0353	0.0153	0.00073	0.008	0.01	0.021	0.014	0.012	0.001	0.00028	1.1e-07	1.6e-05	4.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.3	2.0	2.9	-1.1	-1.7	-1.4
Bipolar Disorder or Schizophrenia	2.4	5.9	10.5	-1.7	-3.2	-2.1
Depressed Affect (Nagel 2018)	0.5	1.1	2.6	-0.7	-0.5	1.6
Depression (Nagel 2018)	0.6	0.8	1.3	-0.5	-1.1	-1.0
Intelligence (Savage-Jansen 2018)	0.8	2.3	6.0	-0.1	-1.0	2.5
Neuroticism (Nagel 2018)	0.1	0.3	0.9	0.1	0.0	0.9
Schizophrenia (2018)	2.0	4.1	8.0	-1.2	-2.8	-1.7
Schizophrenia vs Biploar Disorder	0.4	0.6	0.9	0.7	-0.9	-0.5
Worry (Nagel 2018)	0.6	1.3	2.7	0.8	1.6	0.8
Alzheimer’s Disease (in mother)	0.7	0.8	2.0	0.4	-0.5	-1.4
Alzheimer’s Disease (in father)	1.0	1.1	1.7	1.3	1.1	0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.3	1.1	-0.5	-0.7
Crohns Disease (2017)	0.9	1.9	3.6	-1.5	-0.0	-1.9
Irritable Bowel Disease (IBD)	1.3	3.2	6.9	-2.6	-0.9	-1.3
Ulcerative Colitis (UC)	0.7	1.4	2.8	-1.7	-1.2	-0.2
Major Depression (MDD)	1.3	1.5	2.0	-1.1	-1.4	-1.1
Reaction Time	0.3	0.5	1.1	0.5	-1.1	0.4
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.4	-1.4	-0.6	1.5
Breast Cancer	0.2	0.4	0.7	-0.8	0.5	-0.4
Ovarian Cancer	0.7	0.9	1.6	-0.8	0.6	-1.3
Prostate Cancer	6.6	9.3	12.3	-3.4	-3.5	-2.1
Age at First Birth	0.5	0.7	1.2	0.6	1.1	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	0.8	-0.9	-0.0	-0.8
Coronary Artery Disease (CAD)	0.9	1.1	1.7	1.0	0.7	1.3
Crohns Disease (2012)	0.6	0.9	1.7	-1.3	0.3	-1.0
Mean Putamen Volume	2.0	2.3	3.6	1.9	1.8	0.5
Fasting Glucose	0.6	0.7	2.0	1.4	-0.2	-0.1
HbA1C	0.3	0.3	0.7	-0.9	-0.3	0.1
HDL Cholesterol	0.0	0.1	0.1	0.2	-0.0	-0.3
LDL Cholesterol	0.1	0.2	0.4	0.4	0.1	-0.6
Lupus	0.2	0.3	0.4	-0.5	0.6	0.6
Neuroticism (2016)	0.1	0.2	0.4	-0.2	0.4	0.6
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.1	0.0	0.7
Rheumatoid Arthritis	1.3	1.7	4.8	-0.7	0.0	2.2
Schizophrenia (2014)	2.0	4.5	9.6	-0.6	-3.1	-1.9
Triglycerides	0.1	0.1	0.2	0.3	0.4	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.4	-0.3	0.6	-0.2
Ulcerative Colitis	1.7	2.4	4.4	-2.1	-1.5	0.7
Blood Eosinophil Count	1.2	9.1	10.6	2.6	3.3	3.2
Blood Platelet Count	9.1	105.3	156.2	12.5	8.7	9.1
Blood Red Count	0.2	2.3	3.5	-1.7	1.9	0.9
Blood White Count	0.2	1.3	3.5	-1.9	0.5	0.2
Heel T-Score	0.1	1.1	2.2	-1.5	-0.5	-1.0
BMI	0.2	1.4	3.2	-1.8	0.2	1.0
Height	0.0	0.1	0.1	-0.1	0.4	-0.4
Waist Hip Ratio (WHR)	1.5	6.8	14.4	-3.8	0.3	-2.4
Systolic Blood Pressure	0.4	1.9	3.8	-1.9	-0.9	1.0
Smoking Status	1.4	3.4	5.6	-2.4	-1.9	-1.1
Allergy or Eczema	0.2	0.5	0.9	0.7	0.1	0.9
Cardiovascular Disease	0.1	0.2	0.5	-0.2	-0.7	-0.3
Hypothyroidism (self reported)	0.2	0.4	1.3	0.0	0.3	-1.1
Respiratory disease	0.7	1.6	2.6	1.6	-0.1	1.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.0	-0.8	-1.0	0.1
Lung FEV1/FVC ratio	0.2	0.9	2.4	0.6	-0.1	1.6
Lung FVC	0.3	1.7	2.2	-1.0	-1.4	1.5
Neuroticism	0.2	0.5	1.1	-0.6	-0.0	1.0
Chronotype (morning person)	0.4	1.0	1.9	0.6	1.4	-0.9
Hair Pigment	0.0	0.5	1.3	-0.5	-0.2	-1.1
Tanning	0.1	1.0	2.6	0.2	-0.7	-1.6
Hand grip strength (left)	0.4	1.0	1.8	1.1	1.3	-0.3
Number of treatments/medications taken	0.2	0.4	1.1	-1.1	0.4	0.1
Average weekly spirits intake	0.5	0.7	1.2	0.7	-0.5	1.1
Sensitivity / hurt feelings	1.5	2.5	7.3	0.5	-0.1	2.7
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.6	-1.2	-0.8	-0.5
Hearing difficulty/problems: Yes	0.5	0.7	1.7	-0.1	-1.3	-0.7
Relative age of first facial hair	0.3	0.5	1.2	0.3	1.1	-0.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.0	-1.1	-1.4	0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	-0.9	0.7	-0.2
Ever had hysterectomy (womb removed)	0.2	0.3	0.4	-0.4	-0.6	-0.5
Systolic blood pressure, automated reading	0.6	1.8	3.1	-1.4	-0.5	1.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	0.6	-0.4	0.7
Angina	1.2	1.5	2.5	1.6	0.8	1.2
Medication for hormone replacement therapy	0.1	0.2	0.5	0.1	0.7	0.0
Vitamin and mineral supplements	0.2	0.2	0.6	0.1	-0.3	0.8
Supplements: Zinc	0.7	0.7	1.2	-0.9	-1.1	0.5
Medication: Co-codamol	1.0	1.2	2.4	-1.6	0.0	1.1
Medication: Metformin	0.5	0.7	1.0	-0.7	-0.7	-1.0
Diabetes (father)	0.5	0.6	1.1	-1.1	0.7	0.5
Diabetes (mother)	0.5	0.7	1.3	-0.3	0.7	1.2
Severe depression (siblings)	0.6	0.7	1.9	-0.4	-1.4	-0.3
Pack years adult smoking proportion	0.5	0.7	1.0	-0.5	-1.0	-0.9
Impedance of leg (right)	0.2	0.9	2.4	-0.3	-0.6	-1.5
Leg fat-free mass (left)	0.1	0.6	1.1	-0.4	1.0	0.8
Trunk fat percentage	0.3	1.2	2.9	-0.5	1.7	0.8
Hand grip strength (right)	0.6	1.5	3.2	1.1	1.8	-0.4
Townsend deprivation index at recruitment	0.5	0.7	1.7	-1.3	-0.6	-0.1
Current tobacco smoking	0.9	1.4	1.6	-1.3	-1.2	-1.1
Average weekly fortified wine intake	1.2	1.4	2.0	-0.7	-1.4	-1.4
Maternal smoking around birth	0.0	0.1	0.1	-0.3	0.0	-0.3
Fed-up feelings	0.7	1.2	1.7	-1.3	-0.9	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.5	-0.7	-1.6	-0.5
Relative age voice broke	0.5	0.7	1.8	0.6	1.4	0.1
Taking other prescription medications	0.7	1.1	2.6	-1.6	-0.7	0.5
Age when periods started (menarche)	1.1	2.6	3.9	0.3	-2.0	-2.0
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	4.7	1.0	2.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	4.7	2.2	0.6	1.4
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.6	-1.6	-0.4	0.1
Qualifications: CSEs or equivalent	1.3	1.8	2.8	0.9	1.7	1.3
Serious illness, injury or assault to yourself	0.3	0.3	0.8	0.3	0.9	-0.2
High blood pressure	0.2	0.6	1.5	-1.2	0.3	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.9	0.9	0.0	0.9
Multivitamins +/- minerals	0.5	0.6	1.0	-1.0	-0.2	-0.8
Stomach or abdominal pain in last month	0.5	0.6	1.6	-1.3	-0.2	0.3
Supplements: Glucosamine	3.0	4.0	5.4	1.8	1.8	2.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	-0.8	-0.0	0.7
Medication: Atenolol	1.5	1.9	2.9	1.7	1.7	0.1
Medication: Levothyroxine sodium	0.7	1.2	3.3	-0.2	1.8	0.5
Sitting height	0.1	0.7	1.0	-0.6	0.9	-1.0
Chronic bronchitis/emphysema (father)	0.8	1.0	2.9	0.2	-1.7	0.1
High blood pressure (mother)	1.6	2.2	4.4	-1.4	-2.1	-0.4
Body mass index (BMI)	0.2	1.0	2.2	-0.8	1.5	0.6
Impedance of leg (left)	0.2	0.9	2.1	-0.3	-0.7	-1.4
Leg predicted mass (left)	0.1	0.6	1.1	-0.3	1.1	0.8
Trunk fat mass	0.3	1.3	2.6	-1.0	1.6	0.6
Waist circumference	0.6	2.1	4.2	-2.0	1.4	-0.3
Number of incorrect matches in round	4.7	7.9	14.0	1.6	2.7	3.7
Past tobacco smoking	1.3	2.4	3.6	1.9	1.9	-0.1
Alcohol usually taken with meals	0.5	0.9	2.5	1.6	0.4	0.0
Nervous feelings	1.2	2.2	4.4	1.2	2.1	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	3.6	-1.6	-1.9	-1.5
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.3	-0.2	-0.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	0.2	-1.1	0.1
Had menopause	0.5	0.6	1.1	1.0	0.7	-0.3
Had other major operations	0.1	0.2	0.4	-0.3	-0.6	0.1
Forced vital capacity (FVC)	0.4	1.7	3.1	-1.4	-1.8	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.9	1.7	-0.5	1.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	-0.7	-0.1	-0.2
Qualifications: None of the above	0.0	0.1	0.2	0.1	-0.3	0.4
Financial difficulties in last 2 years	0.6	0.8	1.2	-1.0	0.2	-1.1
Mouth/teeth dental problems	0.7	1.0	2.8	-0.1	-1.7	-0.6
Heart attack	0.4	0.5	1.1	-0.6	-1.0	0.1
Allergy	0.2	0.5	0.8	-0.5	0.6	-0.9
Pain all over the body in last month	0.3	0.3	0.6	-0.5	-0.7	-0.4
Diabetes (self-reported)	0.7	1.1	1.8	-1.2	-1.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.4	-1.2	-0.2	-0.8
Medication: Ramipril	0.1	0.2	0.4	-0.2	0.6	-0.3
Medication: Simvastatin	0.2	0.3	0.8	-0.1	0.3	0.9
Fluid intelligence score	0.6	1.2	2.3	-1.5	-0.8	0.7
Illnesses of siblings	0.2	0.3	0.5	0.1	0.7	-0.6
Neuroticism score	0.9	1.8	2.8	-1.6	0.3	1.7
Weight	0.3	1.4	3.0	-1.1	1.7	0.2
Impedance of arm (right)	0.0	0.1	0.2	-0.2	0.2	-0.4
Arm fat percentage (right)	0.3	1.3	2.5	-1.1	1.6	0.5
Trunk fat-free mass	0.1	0.6	1.0	-0.9	1.0	-0.1
Hip circumference	0.1	0.6	1.5	-1.2	0.5	0.0
Time employed in main current job	3.0	3.5	9.0	3.0	0.5	1.1
Alcohol intake versus 10 years previously	2.3	3.4	9.5	-0.5	0.6	3.1
Father’s age at death	0.2	0.2	0.5	-0.7	0.1	0.5
Worrier / anxious feelings	1.6	3.0	5.4	0.8	2.3	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	0.9	-0.9	-0.2	0.9
Falls in the last year	0.5	0.7	1.9	0.1	0.2	-1.4
Hair/balding pattern: Pattern 3	1.6	2.4	3.3	1.8	0.9	1.7
Number of live births	1.1	1.6	3.5	-0.5	-1.0	-1.9
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.1	-1.5	-1.8	0.7
Pulse rate	2.5	4.3	7.2	2.7	2.3	0.5
Happiness	0.1	0.2	0.3	0.6	0.3	-0.4
Noisy workplace	0.9	1.2	2.5	1.6	0.7	0.8
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	-0.5	-0.7	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.5	0.7	-0.1	0.0
Mouth/teeth dental problems: Dentures	0.8	1.4	3.3	-0.3	1.8	0.9
Asthma	0.5	1.0	1.6	1.1	-0.3	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	1.8	1.3	0.9	-1.1
Medication: Cholesterol lowering	1.3	2.0	2.9	1.3	1.7	1.2
Depression (self-reported)	5.1	6.1	8.8	-3.0	-2.7	-1.5
Medication: Lansoprazole	0.5	0.6	1.4	-1.2	-0.5	-0.4
Prospective memory result	3.8	4.7	6.6	2.0	2.6	1.8
Lung cancer (father)	0.1	0.2	0.4	-0.6	0.2	-0.2
Illnesses of mother	0.2	0.2	0.4	-0.7	0.4	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	4.6	-1.6	-2.1	0.1
Pulse wave Arterial Stiffness index	0.8	0.9	1.5	1.2	1.0	0.4
Impedance of arm (left)	0.0	0.1	0.1	0.3	0.0	-0.4
Arm fat mass (right)	0.4	1.6	2.9	-1.4	1.7	0.3
Trunk predicted mass	0.1	0.6	1.0	-0.8	1.0	0.0
Standing height	0.1	1.0	1.2	-0.9	1.1	-1.0
Length of working week for main job	4.0	4.4	6.5	-2.6	-1.2	-2.3
Exposure to tobacco smoke at home	3.3	3.7	7.1	-1.7	-1.1	-2.7
Breastfed as a baby	0.8	0.9	2.0	1.4	-0.9	0.1
Tense / ‘highly strung’	0.5	0.8	1.6	-1.3	-0.8	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	7.6	-2.8	-1.4	-0.9
Hair/balding pattern: Pattern 4	0.3	0.8	1.8	1.3	-0.6	0.5
Birth weight of first child	0.6	1.1	2.2	-0.1	1.0	1.5
Peak expiratory flow (PEF)	1.0	2.3	3.6	-1.8	-1.9	-0.3
Pulse wave reflection index	1.2	1.4	3.5	-0.9	-1.9	-0.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	-1.1	-0.6	-0.5
Loud music exposure frequency	0.5	0.5	0.9	1.0	0.6	-0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.5	-0.1	1.2	-0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.4	0.2	0.6	1.2
Blood clot in the leg (DVT)	3.7	4.7	8.0	-2.8	-2.1	-1.3
Medication: Paracetamol	0.4	0.6	1.1	-1.0	-0.7	-0.5
Headache pain in last month	0.0	0.0	0.0	0.2	-0.0	-0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.4	0.0	-1.5	0.4
Glaucoma (self-reported)	0.2	0.2	0.5	-0.7	0.1	0.2
Gout (self-reported)	0.5	0.7	1.8	0.2	1.3	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	-0.1	0.8	-0.6
Medication: Amlodipine	0.5	0.7	1.4	-1.2	-0.9	-0.0
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	0.2	-0.2	-0.1
Birth weight	2.4	5.2	6.8	2.0	2.6	2.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	0.4	1.4	0.1
High blood pressure (siblings)	0.3	0.5	0.8	-0.1	-0.8	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.6	3.6	-1.0	-1.9	-0.5
Body fat percentage	0.3	1.0	2.1	-0.7	1.4	0.7
Leg fat percentage (right)	0.2	0.9	1.4	-1.1	1.2	0.2
Arm fat-free mass (right)	0.0	0.2	0.6	-0.2	0.8	0.2
Exposure to tobacco smoke outside home	0.7	0.9	2.2	0.0	-1.5	-0.6
Comparative body size at age 10	1.2	3.2	8.1	1.0	0.9	2.8
Number of full brothers	0.7	0.9	2.2	-1.5	0.1	-0.7
Worry too long after embarrassment	1.3	2.2	4.2	-0.2	2.1	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	3.5	4.6	7.3	-2.7	-2.5	0.1
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	-0.2	-0.4	1.1
Number of children fathered	0.8	0.9	1.2	-1.1	-0.7	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.0	0.1	0.5
Age at first live birth	0.9	1.6	2.4	-1.4	-0.7	-1.5
Pulse wave peak to peak time	1.1	1.3	2.6	-1.6	-1.0	-0.6
Health satisfaction	0.4	0.5	0.9	0.4	0.7	-0.9
Shortness of breath walking on level ground	1.6	1.9	3.8	-0.7	-1.2	-1.9
Qualifications: College or University degree	3.0	9.3	14.7	-3.8	-2.7	-2.5
Eye problems/disorders: None of the above	0.8	0.9	1.4	1.1	1.2	-0.3
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.4	-0.9	-0.9	-1.2
Emphysema/chronic bronchitis	0.4	0.5	0.8	0.9	0.1	0.8
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	-0.1	-0.0	-0.3
Neck or shoulder pain in last month	0.6	0.8	2.1	-0.3	-1.4	0.5
Medication: Blood pressure	0.9	1.5	2.1	-1.1	1.1	-1.4
Angina (self-reported)	1.4	1.8	2.6	1.6	0.8	1.5
Migraine (self-reported)	0.2	0.3	0.5	-0.4	-0.5	0.7
Medication: Ibuprofen	0.6	0.7	0.9	0.9	0.6	-1.0
Medication: Allopurinol	0.5	0.7	1.6	-0.7	-0.1	-1.2
Medication: Omeprazole	0.5	0.6	1.0	-1.0	0.2	0.9
Medication: Seretide 50 evohaler	0.7	0.9	1.4	0.2	1.2	1.1
Mean time to correctly identify matches	0.2	0.4	1.0	1.0	-0.1	-0.3
Heart disease (mother)	0.4	0.5	0.7	-0.8	-0.9	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	0.6	0.2	-0.7
Whole body fat mass	0.3	1.3	3.0	-0.8	1.7	0.5
Leg fat mass (right)	0.3	1.0	1.7	-1.1	1.3	0.4
Arm predicted mass (right)	0.1	0.4	1.0	-0.2	1.0	0.4
Pulse rate, automated reading	2.6	8.5	13.2	3.6	3.4	0.9
Alcohol intake frequency.	0.5	1.2	2.4	-1.0	0.4	1.5
Comparative height size at age 10	0.5	3.0	8.1	0.8	2.9	0.6
Number of full sisters	0.6	0.8	1.9	-0.2	-1.4	-0.6
Suffer from ‘nerves’	0.8	1.3	2.7	-0.9	0.5	1.6
Overall health rating	0.3	0.6	1.4	-0.7	-1.2	-0.0
Chest pain or discomfort	0.7	1.0	1.9	0.4	-0.9	1.4
Had major operations	0.8	1.0	1.7	1.0	-0.4	1.3
Age at last live birth	2.2	3.2	5.4	-1.1	-1.7	-2.3
Family relationship satisfaction	0.3	0.3	0.5	0.7	-0.7	-0.3
Leg pain on walking	0.5	0.7	1.5	-0.7	-0.2	-1.2
Qualifications: NVQ or HND or HNC or equivalent	3.3	3.9	4.9	1.7	2.1	2.2
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.6	-0.7	-1.3	-1.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.9	0.3	-0.2
Medication: Aspirin	0.3	0.4	0.7	-0.6	-0.8	-0.2
Supplements: Vitamin C	0.2	0.2	0.4	0.1	-0.5	0.7
Knee pain experienced in last month	0.1	0.2	0.5	-0.7	-0.2	-0.2
Hypertension (Self-reported)	0.3	0.9	2.4	-1.5	0.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	3.7	-1.9	0.6	-1.1
Illnesses of father: Heart disease	0.3	0.4	0.6	0.8	-0.4	0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.6	0.0	0.8	0.2
Smoking status: Previous	0.5	0.8	0.9	-0.9	-0.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.5	-0.7	-0.7	-0.3
Whole body fat-free mass	0.1	0.5	1.0	-0.7	1.0	0.3
Leg fat-free mass (right)	0.1	0.5	0.8	-0.3	0.9	0.8
Arm fat percentage (left)	0.3	1.3	2.6	-0.8	1.6	0.7
Average weekly red wine intake	1.2	1.7	3.1	-0.1	-1.8	-1.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.5	-0.7	0.3	0.6
Mood swings	1.1	2.1	3.6	-1.9	-1.4	0.8
Loneliness, isolation	2.4	3.3	7.9	-2.8	-1.4	-0.2
Long-standing illness, disability or infirmity	0.6	0.9	1.8	-0.4	-1.3	0.9
Ever had bowel cancer screening	0.6	0.6	1.9	0.0	1.4	-0.2
Diabetes diagnosed by doctor	1.0	1.6	2.9	-1.1	-1.7	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.5	-0.7	-0.7	0.4
Friendships satisfaction	0.3	0.4	0.7	0.0	-0.9	-0.6
Qualifications: nursing, teaching	1.5	2.4	2.8	-1.7	-1.4	-1.5
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.4	-0.3	-0.5
Eye problems/disorders: Cataract	0.5	0.6	0.9	-0.9	-0.5	0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	2.9	0.3	-0.3	-1.7
Medication for cholesterol	0.8	1.2	2.9	1.7	-0.1	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	-0.3	0.9	0.2
Back pain experienced in last month	0.3	0.5	0.8	-0.7	-0.9	-0.3
Mineral and other dietary supplements	0.1	0.1	0.2	-0.1	0.4	-0.4
Breast cancer (self-reported)	0.8	0.9	2.1	1.4	0.8	-0.2
Asthma (self-reported)	0.4	0.8	1.2	1.1	-0.0	1.0
Osteoporosis (self-reported)	0.6	0.7	1.4	-1.2	-0.4	0.7
Osteoarthritis (self-reported)	0.4	0.5	0.9	0.5	0.9	-0.6
Medication: Aspirin	0.2	0.3	0.6	-0.6	-0.7	-0.2
Medication: Gliclazide	2.0	2.3	3.8	-1.2	-2.0	-1.2
Illnesses of father: None of the above (group 1)	0.3	0.3	0.5	-0.1	0.7	-0.7
Smoking status: Current	1.0	1.6	2.1	-1.4	-1.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.7	-1.1	-1.3	0.3
Whole body water mass	0.1	0.4	0.9	-0.6	1.0	0.3
Leg predicted mass (right)	0.1	0.6	0.9	-0.2	1.0	0.9
Arm fat mass (left)	0.4	1.5	3.0	-1.1	1.7	0.4
Number of self-reported non-cancer illnesses	0.6	1.0	2.7	-1.7	0.6	0.1
Average weekly champagne plus white wine intake	0.6	0.8	1.7	1.3	0.9	0.1
Miserableness	0.5	0.9	1.5	-0.9	-0.7	1.2
Guilty feelings	0.0	0.0	0.1	-0.2	-0.2	-0.1
Wears glasses or contact lenses	2.4	2.8	5.5	1.6	2.3	0.5
Ever taken oral contraceptive pill	0.8	0.9	2.6	0.1	0.4	-1.6
Hearing aid user	1.2	1.4	2.8	1.0	1.7	0.6
Mother’s age at death	0.7	0.9	1.4	0.9	1.2	0.7
Financial situation satisfaction	1.0	1.2	2.7	0.9	-0.5	-1.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.4	0.5	0.6	-0.6
Commuting to job workplace: Public transport	0.2	0.3	0.4	0.7	0.2	-0.6
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	-0.8	-0.7	0.3
Medication: Blood pressure	0.6	1.2	3.2	-1.8	-0.5	-0.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.4	-1.6	0.4	-0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.6	0.9	-0.1	1.3
High cholesterol (Self-reported)	1.1	2.0	2.8	1.7	1.4	1.1
Medication: Bendroflumethiazide	0.3	0.4	1.1	-1.1	0.4	-0.2
Medication: Paracetamol	0.5	0.8	1.1	-0.8	-1.0	-0.8
Medication: Lisinopril	1.0	1.3	3.0	-1.7	-0.2	-1.0
Medication: Atorvastatin	4.1	5.1	9.2	3.0	2.4	0.3
Illnesses of father: High blood pressure	1.5	1.9	2.3	-1.3	-1.5	-1.2
Alcohol drinker status: Never	0.2	0.2	0.7	0.1	0.8	-0.0
Ever smoked	1.7	3.0	5.5	-2.3	-1.8	-0.6
Basal metabolic rate	0.1	0.6	1.3	-0.8	1.1	0.3
Leg fat percentage (left)	0.2	0.9	1.5	-1.2	1.1	0.3
Arm fat-free mass (left)	0.1	0.5	0.8	-0.8	0.9	0.1
Number of operations (self-reported)	0.0	0.1	0.2	-0.1	-0.1	0.4
Average weekly beer plus cider intake	0.8	1.2	1.8	-1.1	-0.7	1.4
Irritability	2.4	4.0	6.2	-2.5	-1.7	-1.7
Risk taking	0.4	0.5	0.9	-0.8	-0.3	-0.9
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	-0.6	0.6	-0.2
Fractured/broken bones in last 5 years	0.4	0.5	1.3	0.2	-1.1	-0.5
Age started oral contraceptive pill	1.9	2.4	3.7	-1.9	-0.5	-1.8
Diastolic blood pressure, automated reading	0.3	0.8	1.4	0.3	1.0	1.2
Ever depressed for a whole week	0.3	0.4	0.8	0.6	0.2	0.9
Unable to work because of sickness or disability	1.5	1.9	3.8	-1.1	-1.9	-0.8
Commuting to job workplace: Cycle	1.8	2.1	3.9	-1.6	-2.0	-0.3
Myopia	0.2	0.3	0.8	-0.3	-0.2	0.9
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.4	0.6	-0.3	0.3
Cholesterol lowering medication	0.1	0.1	0.2	0.5	-0.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.6	-1.3	0.3	0.6
Pain experienced in last month	0.2	0.3	1.0	0.1	-0.2	-1.0
Supplements: Calcium	0.3	0.4	0.7	-0.8	-0.5	0.4
Basal cell carcinoma (self-reported)	1.0	1.2	2.2	-0.8	-1.5	-0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	-0.7	-1.1	0.0
Deep venous thrombosis (DVT) (self-reported)	3.6	4.6	8.2	-2.9	-2.0	-1.2
Heart disease (siblings)	0.4	0.4	1.0	-0.1	-1.0	-0.5
Alcohol drinker status: Previous	0.1	0.2	0.4	-0.2	-0.6	-0.2
Pack years of smoking	0.3	0.4	0.5	-0.5	-0.7	-0.7
Impedance of whole body	0.1	0.3	0.8	-0.0	-0.2	-0.9
Leg fat mass (left)	0.3	1.1	1.6	-1.2	1.3	0.3
Arm predicted mass (left)	0.1	0.5	0.9	-0.9	0.8	-0.0