Hub : Genes

EIF4EBP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.1540	0.0470	0.00086	0.004	NA	0.011	NA	0.004	1.2e-01	NA	3.2e-02	NA	1.2e-01
2	NTR	Blood	0.0385	0.0142	0.00360	0.025	0.004	0.016	0.015	0.022	1.1e-08	1.4e-02	3.4e-06	7.8e-06	8.0e-08
3	YFS	Blood	0.2150	0.0263	0.00000	0.207	0.250	0.268	NA	0.269	7.8e-66	4.5e-81	1.1e-87	NA	3.2e-88

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	1.1	0.7	-1.1	0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	1.5	-0.7	0.5	-1.2
Depressed Affect (Nagel 2018)	0.7	1.5	4.1	0.6	0.4	-2.0
Depression (Nagel 2018)	0.9	1.3	2.0	0.5	1.4	-1.3
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.9	-0.8	0.2	1.7
Neuroticism (Nagel 2018)	1.0	2.2	3.8	2.0	0.7	-1.5
Schizophrenia (2018)	1.3	2.7	3.4	-1.5	1.6	-1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	2.2	-1.5	-0.3	-0.7
Worry (Nagel 2018)	0.3	0.6	1.2	1.1	0.5	-0.6
Alzheimer’s Disease (in mother)	1.3	1.5	3.0	-0.7	1.0	-1.7
Alzheimer’s Disease (in father)	1.7	1.9	4.7	-0.1	1.0	-2.2
Alzheimer’s Disease (including proxy)	3.0	4.3	9.8	-0.8	1.5	-3.1
Crohns Disease (2017)	0.4	0.8	1.4	1.2	0.1	1.0
Irritable Bowel Disease (IBD)	0.4	0.8	1.9	0.7	0.3	1.4
Ulcerative Colitis (UC)	0.2	0.4	1.2	-0.1	-0.1	1.1
Major Depression (MDD)	2.9	3.5	9.9	-3.1	0.8	-0.3
Reaction Time	0.8	1.6	2.2	-1.1	1.1	-1.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.1	-0.1	0.1	1.4
Breast Cancer	1.3	3.1	5.6	-0.8	-1.8	2.4
Ovarian Cancer	0.3	0.4	0.9	0.1	-0.9	0.4
Prostate Cancer	0.4	0.5	1.5	0.3	-1.2	0.0
Age at First Birth	0.5	0.7	1.6	-0.4	1.3	0.5
Bipolar Disorder (2011)	0.6	0.6	0.7	0.6	0.8	-0.8
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	-1.1	-0.0	0.4
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.1	-0.0	-0.2
Crohns Disease (2012)	1.4	2.3	5.2	2.3	1.2	0.6
Mean Putamen Volume	0.4	0.5	1.3	-0.2	1.1	-0.2
Fasting Glucose	1.0	1.2	3.5	0.4	1.9	-0.1
HbA1C	1.2	1.3	1.4	1.2	1.2	1.1
HDL Cholesterol	1.0	1.6	4.2	-0.7	-0.2	2.1
LDL Cholesterol	0.2	0.3	0.9	0.1	-0.2	-0.9
Lupus	0.1	0.2	0.4	0.2	0.1	0.6
Neuroticism (2016)	1.0	1.4	3.6	1.9	-0.0	-0.8
Primary Biliary Cirrhosis	0.4	0.6	1.6	-0.2	1.3	0.5
Rheumatoid Arthritis	0.2	0.2	0.6	-0.1	0.8	0.2
Schizophrenia (2014)	1.3	2.8	4.4	-2.1	1.0	-1.7
Triglycerides	0.1	0.2	0.6	0.8	-0.1	-0.1
Type 2 Diabetes (T2D) (2012)	1.0	1.1	1.9	1.4	-0.3	-1.2
Ulcerative Colitis	0.4	0.5	0.6	0.7	0.8	-0.7
Blood Eosinophil Count	0.0	0.1	0.2	0.1	0.5	0.4
Blood Platelet Count	0.0	0.5	0.7	0.8	0.5	-0.8
Blood Red Count	0.2	2.1	3.6	-1.9	0.2	-1.6
Blood White Count	0.1	1.0	1.8	0.1	1.1	1.4
Heel T-Score	0.4	3.1	5.6	1.3	-2.4	1.5
BMI	0.2	0.9	1.5	-1.2	-1.1	0.4
Height	0.7	13.8	34.1	0.7	-2.6	5.8
Waist Hip Ratio (WHR)	0.0	0.2	0.4	0.4	-0.6	-0.0
Systolic Blood Pressure	0.2	1.0	1.5	-1.2	0.6	-1.0
Smoking Status	0.1	0.3	0.6	0.2	-0.5	0.8
Allergy or Eczema	0.2	0.4	1.0	-1.0	0.2	0.4
Cardiovascular Disease	0.1	0.4	0.8	-0.9	0.1	-0.6
Hypothyroidism (self reported)	0.2	0.4	0.6	-0.1	-0.8	0.8
Respiratory disease	0.1	0.3	0.6	0.6	0.8	0.0
Type 2 Diabetes (T2D) (2018)	1.2	2.2	4.3	1.4	-2.1	-0.6
Lung FEV1/FVC ratio	0.4	2.2	4.0	0.3	-1.6	2.0
Lung FVC	0.0	0.2	0.3	-0.4	-0.4	-0.5
Neuroticism	0.3	0.8	1.3	1.1	-0.2	-1.0
Chronotype (morning person)	0.1	0.3	0.5	0.3	-0.7	-0.6
Hair Pigment	0.0	0.3	0.3	-0.6	-0.6	-0.5
Tanning	0.1	0.7	1.7	-0.4	0.5	-1.3
Hand grip strength (left)	0.1	0.4	0.5	-0.6	-0.7	0.6
Number of treatments/medications taken	0.1	0.1	0.3	-0.5	0.1	-0.4
Average weekly spirits intake	0.1	0.1	0.3	0.3	-0.5	-0.2
Sensitivity / hurt feelings	0.9	1.5	2.1	1.4	1.3	-0.9
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.6	0.2	1.9	-1.6
Hearing difficulty/problems: Yes	2.9	4.4	7.5	-1.6	2.7	-1.8
Relative age of first facial hair	0.0	0.1	0.2	-0.2	-0.5	-0.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.7	-1.9	-0.0	-0.1
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.4	-0.5	-1.2	-0.3
Ever had hysterectomy (womb removed)	2.0	2.2	3.3	-1.5	1.8	1.1
Systolic blood pressure, automated reading	0.3	1.0	2.5	-1.6	-0.6	0.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.4	0.6	-1.6	-0.5
Angina	0.6	0.8	1.4	-0.9	-0.4	1.2
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.3	0.8	-0.3
Vitamin and mineral supplements	2.3	3.1	8.3	-1.0	0.1	-2.9
Supplements: Zinc	0.1	0.2	0.5	-0.0	0.1	0.7
Medication: Co-codamol	1.7	1.9	5.7	-2.4	-0.3	-0.1
Medication: Metformin	0.3	0.4	0.8	-0.4	-0.4	-0.9
Diabetes (father)	0.3	0.4	0.8	-0.4	-0.5	-0.9
Diabetes (mother)	1.3	1.7	3.4	1.8	-0.7	-1.1
Severe depression (siblings)	1.5	1.7	3.7	1.9	1.0	-0.6
Pack years adult smoking proportion	1.1	1.7	2.6	0.6	1.4	-1.6
Impedance of leg (right)	0.3	1.7	4.1	-1.0	0.1	-2.0
Leg fat-free mass (left)	0.4	2.1	5.8	-0.2	-0.6	2.4
Trunk fat percentage	0.7	2.6	6.6	-2.6	-0.6	-0.9
Hand grip strength (right)	0.3	0.8	1.1	-0.8	-0.7	1.0
Townsend deprivation index at recruitment	0.3	0.4	1.2	-0.1	1.1	0.4
Current tobacco smoking	1.2	1.9	3.4	-0.9	1.8	-1.3
Average weekly fortified wine intake	0.2	0.3	0.3	-0.5	-0.5	0.5
Maternal smoking around birth	0.3	0.4	0.9	0.9	-0.2	-0.6
Fed-up feelings	0.2	0.4	0.6	0.7	0.2	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	4.6	-0.5	2.1	-0.8
Relative age voice broke	0.4	0.6	1.4	-1.2	-0.3	-0.5
Taking other prescription medications	0.7	1.2	1.9	-0.4	-1.4	1.2
Age when periods started (menarche)	1.0	2.5	5.2	1.2	-0.9	2.3
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.3	-1.1	0.5	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	4.2	-0.3	-1.7	2.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	-0.4	0.0	-1.1
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.3	-0.7	0.6
Serious illness, injury or assault to yourself	0.4	0.5	1.2	-0.7	-0.1	-1.1
High blood pressure	0.4	1.0	2.7	-0.5	-0.3	-1.6
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.0	-1.0	0.1	0.2
Multivitamins +/- minerals	1.3	1.6	2.8	1.4	0.2	1.7
Stomach or abdominal pain in last month	0.3	0.4	1.0	-1.0	0.1	-0.4
Supplements: Glucosamine	0.3	0.4	1.1	1.1	0.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	-0.6	0.2	-0.2
Medication: Atenolol	3.5	4.4	12.6	-3.5	-0.4	0.6
Medication: Levothyroxine sodium	0.7	1.2	3.3	-1.8	0.4	0.2
Sitting height	0.9	6.1	17.2	0.2	-1.1	4.2
Chronic bronchitis/emphysema (father)	2.6	3.0	8.5	-0.6	0.5	-2.9
High blood pressure (mother)	0.5	0.7	1.8	1.3	-0.6	-0.3
Body mass index (BMI)	0.3	1.3	3.6	-1.9	0.0	-0.5
Impedance of leg (left)	0.3	1.5	4.1	-0.5	0.1	-2.0
Leg predicted mass (left)	0.4	2.1	5.8	-0.3	-0.6	2.4
Trunk fat mass	0.5	2.0	4.9	-2.2	-1.0	0.1
Waist circumference	0.2	0.9	2.6	-1.6	-0.1	-0.1
Number of incorrect matches in round	0.0	0.0	0.0	-0.2	-0.1	0.0
Past tobacco smoking	0.7	1.3	2.3	-0.2	1.2	-1.5
Alcohol usually taken with meals	0.9	1.4	4.2	2.0	-0.0	0.4
Nervous feelings	0.9	1.7	4.0	2.0	1.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	3.8	1.1	1.1	-1.9
Hearing difficulty/problems with background noise	0.8	1.2	2.2	0.4	1.5	-1.1
Hair/balding pattern: Pattern 2	1.3	1.6	2.3	-1.3	1.5	-0.9
Had menopause	1.0	1.2	2.5	-0.2	-1.6	1.0
Had other major operations	3.9	4.8	9.6	-0.9	-2.0	3.1
Forced vital capacity (FVC)	0.8	3.1	5.0	0.1	-2.2	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.6	0.3	-1.6	1.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.6	-0.6	0.4	-1.6
Qualifications: None of the above	0.7	1.4	3.5	-0.9	0.2	-1.9
Financial difficulties in last 2 years	1.2	1.6	2.9	0.2	1.7	-1.3
Mouth/teeth dental problems	0.5	0.7	1.3	-0.3	-1.1	0.8
Heart attack	0.5	0.6	1.2	-0.7	1.1	-0.3
Allergy	0.1	0.3	0.4	0.7	0.3	-0.5
Pain all over the body in last month	1.5	1.6	3.9	2.0	-0.2	0.9
Diabetes (self-reported)	1.4	2.1	3.8	0.8	-2.0	-1.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.0	1.0	-0.6	0.4
Medication: Ramipril	0.2	0.3	0.7	-0.8	0.5	-0.3
Medication: Simvastatin	1.6	2.4	3.7	-1.9	1.6	-0.8
Fluid intelligence score	0.3	0.7	1.9	-0.3	0.3	1.4
Illnesses of siblings	0.6	0.8	2.1	-0.6	1.4	-0.2
Neuroticism score	0.8	1.7	2.3	1.2	1.1	-1.5
Weight	0.4	1.8	2.5	-1.6	-0.7	1.5
Impedance of arm (right)	0.0	0.2	0.3	-0.4	0.6	-0.3
Arm fat percentage (right)	0.6	2.5	6.3	-2.5	0.3	-1.0
Trunk fat-free mass	0.6	3.6	8.9	0.2	-1.3	3.0
Hip circumference	0.3	1.2	3.3	-1.8	0.6	0.2
Time employed in main current job	0.1	0.1	0.3	0.2	0.2	-0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.5	0.2	-0.7	-0.5
Father’s age at death	2.1	2.8	4.6	0.7	1.8	-2.1
Worrier / anxious feelings	0.4	0.7	1.6	1.3	-0.5	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.5	-1.2	0.8	-0.6
Falls in the last year	0.3	0.4	0.4	-0.7	-0.6	-0.6
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	-0.1	-0.7	0.8
Number of live births	0.4	0.6	1.8	-1.4	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	4.8	0.6	-2.2	2.1
Pulse rate	1.0	1.6	3.2	0.5	1.8	-1.2
Happiness	1.4	1.7	3.1	-1.8	1.4	-0.4
Noisy workplace	0.2	0.3	0.4	0.6	0.5	0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.8	0.7	-0.4	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.1	0.4	0.5
Mouth/teeth dental problems: Dentures	0.6	1.1	2.0	-1.1	-0.2	-1.4
Asthma	0.1	0.2	0.7	0.1	-0.8	-0.0
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	4.7	2.2	-0.5	0.5
Medication: Cholesterol lowering	0.3	0.4	1.3	-1.1	0.1	-0.2
Depression (self-reported)	1.2	1.4	2.0	1.4	0.4	-1.4
Medication: Lansoprazole	2.1	2.4	2.5	-1.6	1.6	-1.5
Prospective memory result	0.4	0.5	0.7	-0.8	0.9	-0.5
Lung cancer (father)	0.6	0.7	1.7	-0.4	0.4	-1.3
Illnesses of mother	0.1	0.1	0.2	-0.5	0.2	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	6.4	-0.1	-1.6	2.5
Pulse wave Arterial Stiffness index	0.9	1.1	2.2	0.3	-1.5	1.0
Impedance of arm (left)	0.2	0.7	0.8	-0.8	0.9	-0.9
Arm fat mass (right)	0.6	2.3	6.9	-2.6	-0.1	-0.1
Trunk predicted mass	0.6	3.4	8.5	0.2	-1.3	2.9
Standing height	0.7	7.2	19.0	0.1	-1.6	4.4
Length of working week for main job	1.9	2.1	5.4	0.2	2.3	-0.9
Exposure to tobacco smoke at home	0.3	0.3	0.8	0.9	0.3	0.1
Breastfed as a baby	0.5	0.7	2.0	1.4	-0.1	0.1
Tense / ‘highly strung’	0.5	0.8	1.4	1.2	0.6	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	4.4	0.2	2.1	-1.3
Hair/balding pattern: Pattern 4	0.5	1.2	1.9	-0.5	-1.4	-1.1
Birth weight of first child	0.4	0.7	1.3	-0.8	-1.1	0.4
Peak expiratory flow (PEF)	1.0	2.4	3.5	1.2	-1.9	1.5
Pulse wave reflection index	0.5	0.6	0.9	-0.6	-1.0	0.7
Ever highly irritable/argumentative for 2 days	0.9	1.0	1.8	1.1	-1.3	-0.2
Loud music exposure frequency	0.8	0.9	1.6	0.7	0.8	-1.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.2	1.8	0.4	1.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.6	1.6	1.5	0.1
Blood clot in the leg (DVT)	2.3	3.0	6.2	-2.5	1.1	-1.2
Medication: Paracetamol	0.1	0.2	0.6	0.8	0.2	-0.2
Headache pain in last month	0.8	1.4	3.5	1.9	-0.8	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.2	0.4	1.1	-0.6
Glaucoma (self-reported)	0.0	0.0	0.1	-0.1	-0.2	-0.2
Gout (self-reported)	2.4	3.2	5.3	0.0	-2.1	2.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.8	-1.7	-0.0	0.3
Medication: Amlodipine	1.9	2.6	7.1	-0.8	-0.4	-2.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.4	1.6	0.8	-1.1
Birth weight	0.3	0.6	0.9	0.5	-0.9	1.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.4	-0.2	0.7
High blood pressure (siblings)	0.4	0.6	1.1	0.7	-1.0	0.3
Forced vital capacity (FVC), Best measure	0.8	2.8	6.0	-0.5	-1.5	2.4
Body fat percentage	0.6	2.5	5.8	-2.4	-0.4	-1.3
Leg fat percentage (right)	0.9	3.2	5.1	-2.3	-0.1	-2.1
Arm fat-free mass (right)	0.3	1.6	3.1	-0.9	-0.9	1.8
Exposure to tobacco smoke outside home	0.4	0.6	1.7	0.3	1.3	-0.2
Comparative body size at age 10	0.8	2.2	5.6	0.8	2.4	-0.6
Number of full brothers	0.5	0.6	1.3	0.3	-1.1	0.6
Worry too long after embarrassment	1.2	2.0	5.0	2.2	0.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.5	0.4	1.9	-1.7
Wheeze or whistling in the chest in last year	1.7	3.0	4.4	-0.9	1.9	-2.1
Number of children fathered	0.6	0.6	1.8	-0.3	-1.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	-0.1	0.1	-0.1
Age at first live birth	0.3	0.6	1.7	0.3	-0.1	1.3
Pulse wave peak to peak time	0.8	0.9	2.3	-0.3	1.5	-0.5
Health satisfaction	0.4	0.6	0.9	-0.9	0.1	-0.9
Shortness of breath walking on level ground	1.0	1.1	3.3	-0.1	0.3	-1.8
Qualifications: College or University degree	0.5	1.6	2.7	-1.6	0.2	1.4
Eye problems/disorders: None of the above	0.7	0.8	1.0	0.7	1.0	0.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.5	-0.7	1.2	0.7
Emphysema/chronic bronchitis	0.7	0.8	1.2	0.9	-0.7	1.1
Medication for pain relief, constipation, heartburn	0.9	1.5	3.3	0.1	-1.1	1.8
Neck or shoulder pain in last month	1.3	1.8	2.5	-1.5	-1.6	0.9
Medication: Blood pressure	0.9	1.6	3.6	-0.0	-1.9	1.1
Angina (self-reported)	0.5	0.6	1.2	-0.8	-0.4	1.1
Migraine (self-reported)	1.9	2.4	6.7	2.6	0.2	-0.6
Medication: Ibuprofen	1.1	1.3	2.7	1.6	-0.5	1.0
Medication: Allopurinol	1.4	1.8	2.6	-0.8	-1.5	1.6
Medication: Omeprazole	0.6	0.7	1.1	-1.1	0.9	-0.3
Medication: Seretide 50 evohaler	0.3	0.3	0.7	0.0	-0.4	-0.9
Mean time to correctly identify matches	0.6	1.1	2.4	-0.7	0.4	-1.6
Heart disease (mother)	0.1	0.2	0.3	0.5	0.3	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.3	0.6	-1.3	1.8
Whole body fat mass	0.4	1.8	5.0	-2.2	-0.6	0.0
Leg fat mass (right)	0.4	1.7	4.8	-2.2	-0.1	-0.6
Arm predicted mass (right)	0.4	2.0	3.8	-0.7	-1.2	1.9
Pulse rate, automated reading	0.3	1.1	1.7	1.1	0.6	-1.3
Alcohol intake frequency.	0.8	1.8	4.4	-0.2	1.0	-2.1
Comparative height size at age 10	0.6	3.2	6.3	0.5	-1.8	2.5
Number of full sisters	0.6	0.7	1.9	-0.1	-0.5	1.4
Suffer from ‘nerves’	2.0	3.2	6.1	1.8	2.5	-0.4
Overall health rating	0.9	1.8	4.1	-2.0	-0.3	-1.2
Chest pain or discomfort	1.9	2.8	5.1	-1.1	2.2	-1.4
Had major operations	1.2	1.4	2.6	0.5	1.6	-1.2
Age at last live birth	1.2	1.8	4.0	-2.0	1.0	-0.7
Family relationship satisfaction	2.5	3.1	5.9	-2.4	1.5	1.1
Leg pain on walking	0.3	0.3	0.8	0.9	0.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.4	0.0	0.6	-0.6
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.9	-0.6	0.5	-1.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.0	-1.0	-0.9	0.8
Medication: Aspirin	0.4	0.5	0.8	-0.7	0.4	-0.9
Supplements: Vitamin C	0.8	1.0	2.0	-0.9	0.4	1.4
Knee pain experienced in last month	0.5	0.7	1.7	-1.3	0.6	-0.4
Hypertension (Self-reported)	0.4	1.1	2.2	-0.9	-0.6	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	4.4	-1.3	2.1	-0.7
Illnesses of father: Heart disease	2.8	3.9	5.0	2.2	-2.1	1.5
Illnesses of siblings: Diabetes	1.1	1.4	3.1	-1.0	0.2	-1.8
Smoking status: Previous	1.8	2.7	4.2	0.2	-2.0	2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.1	-0.1	-0.1	1.4
Whole body fat-free mass	0.5	2.9	7.6	0.1	-1.0	2.8
Leg fat-free mass (right)	0.4	2.2	6.4	0.0	-0.4	2.5
Arm fat percentage (left)	0.7	2.9	6.5	-2.5	0.6	-1.3
Average weekly red wine intake	0.5	0.8	1.1	0.9	0.8	1.1
Handedness (chirality/laterality): Left-handed	2.0	2.5	4.3	1.3	-1.2	2.1
Mood swings	1.0	1.8	3.2	1.0	1.0	-1.8
Loneliness, isolation	1.5	2.1	5.0	0.5	2.2	-1.0
Long-standing illness, disability or infirmity	1.0	1.6	3.0	-1.3	-1.7	-0.0
Ever had bowel cancer screening	0.6	0.7	1.8	1.3	-0.3	0.6
Diabetes diagnosed by doctor	1.2	1.9	4.0	0.7	-2.0	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.6	0.7	0.8	-0.3
Friendships satisfaction	1.1	1.3	3.6	-1.9	-0.5	0.2
Qualifications: nursing, teaching	0.3	0.4	0.9	0.7	0.9	0.1
Commuting to job workplace: Walk	0.5	0.5	1.3	-0.4	-1.1	0.4
Eye problems/disorders: Cataract	0.3	0.4	1.0	-1.0	-0.2	0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.4	0.6	0.1
Medication for cholesterol	1.7	2.6	5.0	1.6	-0.5	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.7	-0.6	-1.3	0.4
Back pain experienced in last month	0.1	0.1	0.2	-0.5	0.1	0.1
Mineral and other dietary supplements	0.4	0.5	0.9	0.4	-0.7	-1.0
Breast cancer (self-reported)	1.7	2.0	5.2	-0.8	0.3	2.3
Asthma (self-reported)	0.0	0.1	0.3	0.1	-0.5	-0.2
Osteoporosis (self-reported)	0.6	0.8	1.6	-1.3	-0.9	0.1
Osteoarthritis (self-reported)	1.5	2.0	5.3	0.2	0.7	-2.3
Medication: Aspirin	0.7	0.9	2.2	-0.8	0.3	-1.5
Medication: Gliclazide	1.0	1.1	1.6	-1.3	-1.2	-0.5
Illnesses of father: None of the above (group 1)	2.0	2.5	6.7	-0.8	-0.4	2.6
Smoking status: Current	0.9	1.4	2.5	-0.7	1.6	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.9	0.2	-1.0	0.9
Whole body water mass	0.5	2.9	7.7	-0.1	-1.0	2.8
Leg predicted mass (right)	0.4	2.2	6.3	0.0	-0.5	2.5
Arm fat mass (left)	0.5	2.1	6.2	-2.5	0.0	-0.2
Number of self-reported non-cancer illnesses	0.4	0.6	1.1	-0.8	-0.4	-1.1
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.1	0.7	-0.4
Miserableness	0.9	1.5	3.9	2.0	-0.2	-0.7
Guilty feelings	0.9	1.4	3.8	2.0	0.3	-0.5
Wears glasses or contact lenses	0.3	0.3	0.8	0.9	-0.3	0.4
Ever taken oral contraceptive pill	3.9	4.3	6.2	2.5	-1.1	2.4
Hearing aid user	0.4	0.5	0.7	-0.8	-0.8	-0.1
Mother’s age at death	0.7	0.8	1.8	-1.4	-0.4	0.7
Financial situation satisfaction	0.3	0.3	0.7	0.5	0.2	0.8
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.2	0.1	-1.6	1.8
Commuting to job workplace: Public transport	1.7	2.0	3.6	-0.2	1.9	-1.6
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	0.9	0.2	-0.5
Medication: Blood pressure	1.3	2.5	5.3	-1.4	-0.1	-2.3
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.2	-1.5	1.4	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	-0.5	0.9	0.1
High cholesterol (Self-reported)	0.6	1.1	2.1	-1.5	1.0	0.6
Medication: Bendroflumethiazide	0.8	1.2	3.3	-1.8	0.3	-0.6
Medication: Paracetamol	0.3	0.5	1.3	1.1	0.4	0.1
Medication: Lisinopril	0.3	0.4	0.7	-0.8	-0.0	-0.6
Medication: Atorvastatin	0.4	0.5	1.4	0.3	-0.0	-1.2
Illnesses of father: High blood pressure	0.1	0.1	0.1	0.3	-0.2	-0.3
Alcohol drinker status: Never	1.1	1.4	2.0	-0.7	1.4	-1.3
Ever smoked	0.2	0.4	0.6	-0.6	0.8	0.5
Basal metabolic rate	0.4	2.3	5.7	-0.5	-0.9	2.4
Leg fat percentage (left)	0.6	2.3	3.7	-1.8	-0.3	-1.9
Arm fat-free mass (left)	0.4	2.3	4.8	-0.8	-1.2	2.2
Number of operations (self-reported)	0.7	1.0	1.7	-0.8	-0.8	1.3
Average weekly beer plus cider intake	1.0	1.5	1.7	-1.0	1.3	-1.3
Irritability	0.4	0.8	1.8	-0.6	0.2	-1.3
Risk taking	0.5	0.8	2.0	1.4	0.2	-0.5
Ever had prostate specific antigen (PSA) test	1.9	2.2	2.9	1.7	-0.8	1.7
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.7	-0.2	0.6
Age started oral contraceptive pill	1.4	1.7	3.7	1.9	-0.4	1.2
Diastolic blood pressure, automated reading	0.1	0.3	0.6	0.4	-0.7	0.6
Ever depressed for a whole week	0.9	1.1	1.4	0.6	-1.2	-1.2
Unable to work because of sickness or disability	1.4	1.9	2.8	-1.0	-1.4	-1.7
Commuting to job workplace: Cycle	2.2	2.6	4.0	0.3	-2.0	2.0
Myopia	1.9	2.7	6.3	2.5	-0.4	1.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.0	0.7	-0.2	1.4
Cholesterol lowering medication	0.9	1.4	2.1	-1.0	1.0	-1.4
Medication: Omeprazole (e.g. Zanprol)	2.4	3.0	6.4	-2.5	1.2	-1.0
Pain experienced in last month	0.0	0.1	0.1	-0.0	-0.2	0.4
Supplements: Calcium	1.4	1.5	2.3	1.5	0.1	1.5
Basal cell carcinoma (self-reported)	2.9	3.4	5.3	-2.3	2.1	-0.7
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.7	-0.9	1.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	5.5	-2.4	0.9	-1.3
Heart disease (siblings)	0.7	0.8	1.3	1.1	-0.9	0.6
Alcohol drinker status: Previous	1.0	1.1	2.7	0.3	0.7	-1.6
Pack years of smoking	1.1	1.6	2.5	0.7	1.4	-1.6
Impedance of whole body	0.2	1.0	2.2	-0.8	0.3	-1.5
Leg fat mass (left)	0.4	1.4	3.9	-2.0	-0.3	-0.5
Arm predicted mass (left)	0.4	2.2	4.5	-0.6	-1.3	2.1