TWAS hub - EIF5A2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.104	0.0391	0.0023	-0.002	NA	0.027	NA	0.017	0.48	NA	0.0031	NA	0.016
2	GTEx	Cells Transformed fibroblasts	0.100	0.0380	0.0023	-0.001	NA	-0.001	NA	-0.003	0.36	NA	0.4200	NA	0.620

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Qualifications: CSEs or equivalent	5.1	6.7	6.7	-2.6	-2.6
Migraine (self-reported)	4.3	5.4	8.0	-1.7	2.8
Knee pain experienced in last month	4.3	6.7	9.6	-3.1	-2.0
Average weekly fortified wine intake	4.2	4.9	6.2	-2.5	-1.9
Body mass index (BMI)	4.1	17.3	33.2	-1.2	-5.8
Chronic bronchitis/emphysema (mother)	4.0	4.7	9.0	-0.6	-3.0
Fasting Glucose	3.9	4.7	5.4	-2.0	2.3
Leg fat mass (left)	3.6	13.9	26.2	-1.3	-5.1
Leg fat mass (right)	3.5	13.5	26.0	-1.0	-5.1
Arm fat mass (left)	3.5	14.4	27.0	-1.3	-5.2
Had menopause	3.4	4.2	8.4	2.9	-0.4
Health satisfaction	3.4	4.5	5.3	1.9	-2.3
Impedance of arm (right)	3.3	15.4	30.6	0.5	5.5
Arm fat mass (right)	3.3	13.5	25.2	-1.4	-5.0
BMI	3.2	18.5	37.0	-0.2	-6.1
Headache pain in last month	3.2	5.5	7.8	-1.8	2.8
Number of full sisters	3.2	3.9	6.2	-1.3	-2.5
Number of operations (self-reported)	3.2	4.8	9.4	-0.4	-3.1
Had other major operations	3.1	3.8	7.5	0.3	-2.7
Weight	3.1	15.1	28.7	-1.2	-5.4
Mouth/teeth dental problems: Loose teeth	3.1	3.7	5.5	1.4	-2.3
Whole body fat mass	3.1	13.0	23.9	-1.5	-4.9
Osteoarthritis (self-reported)	3.1	4.0	8.0	-0.0	-2.8
Waist circumference	3.0	11.0	21.9	-0.4	-4.7
Heart disease (mother)	3.0	3.7	5.2	-2.3	-1.5
Medication: Ibuprofen	2.9	3.4	6.5	-0.6	-2.5
Had major operations	2.9	3.4	4.8	-1.4	-2.2
Maternal smoking around birth	2.6	3.8	4.9	-2.2	-1.6
Hip circumference	2.6	11.1	21.0	-1.0	-4.6
Arm predicted mass (right)	2.6	13.2	25.6	-0.9	-5.1
Arm fat percentage (left)	2.6	10.5	19.5	-1.2	-4.4
Arm fat-free mass (left)	2.6	13.1	24.6	-1.3	-5.0
Trunk fat mass	2.5	10.9	20.0	-1.4	-4.5
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	5.2	-1.1	-2.3
Arm fat-free mass (right)	2.5	12.7	24.4	-1.0	-4.9
Long-standing illness, disability or infirmity	2.5	3.8	6.7	0.9	-2.6
Impedance of whole body	2.5	12.6	25.1	0.0	5.0
Impedance of arm (left)	2.4	11.3	22.7	0.1	4.8
Body fat percentage	2.4	9.6	17.5	-1.3	-4.2
Medication: Gliclazide	2.4	2.7	5.4	0.2	2.3
Leg fat percentage (left)	2.4	8.8	16.1	-1.2	-4.0
Arm predicted mass (left)	2.4	12.4	23.9	-1.0	-4.9
Prostate Cancer	2.3	3.3	3.8	-1.9	1.7
Leg fat-free mass (left)	2.3	12.0	22.6	-1.2	-4.8
Leg predicted mass (left)	2.3	12.0	22.8	-1.1	-4.8
Heart attack	2.3	2.9	3.9	-1.4	-2.0
Medication: Ventolin 100micrograms inhaler	2.3	3.0	6.0	2.4	0.0
Leg fat-free mass (right)	2.3	12.1	22.2	-1.4	-4.7
Arm fat percentage (right)	2.2	8.6	15.9	-1.2	-4.0
Leg fat percentage (right)	2.2	8.0	15.4	-0.7	-3.9
Leg predicted mass (right)	2.2	11.6	21.3	-1.4	-4.6
Basal metabolic rate	2.2	12.3	22.8	-1.4	-4.8
Worry (Nagel 2018)	2.1	4.5	9.1	-0.1	3.0
Type 2 Diabetes (T2D) (2018)	2.1	3.9	6.2	-1.2	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	5.4	0.5	-2.3
Impedance of leg (left)	2.1	10.3	20.5	-0.2	4.5
Impedance of leg (right)	2.0	9.7	19.1	0.5	4.4
Trunk fat percentage	2.0	7.9	13.6	-1.5	-3.7
High blood pressure (mother)	2.0	2.9	4.1	-2.0	1.3
Pulse rate	2.0	3.4	4.4	1.5	-2.1
Mean time to correctly identify matches	2.0	3.8	6.5	2.5	1.1
Osteoporosis (self-reported)	2.0	2.5	4.9	2.2	0.1
Pain type(s) experienced in last month: Hip pain	2.0	2.5	4.1	2.0	-0.9
Whole body fat-free mass	1.9	10.8	20.1	-1.2	-4.5
Whole body water mass	1.9	10.8	20.3	-1.2	-4.5
Schizophrenia (2018)	1.8	3.8	7.3	-0.5	-2.7
Lupus	1.8	2.8	4.1	2.0	-1.2
Illnesses of mother	1.8	2.3	3.9	2.0	0.8
Chest pain or discomfort	1.8	2.6	3.8	-1.9	-1.2
Heart attack/myocardial infarction (self-reported)	1.8	2.4	2.9	-1.4	-1.7
Reaction Time	1.7	3.3	3.6	1.9	1.7
Chronic bronchitis/emphysema (father)	1.7	1.9	3.9	-0.0	-2.0
Happiness	1.7	2.0	3.5	1.9	-0.7
Medication: Atorvastatin	1.7	2.1	4.0	-2.0	-0.6
Commuting to job workplace: Cycle	1.7	2.1	3.9	2.0	-0.6
Schizophrenia vs Biploar Disorder	1.6	2.1	2.7	1.2	-1.6
Type 2 Diabetes (T2D) (2012)	1.6	1.9	3.5	-0.6	1.9
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	3.8	0.7	-1.9
Supplements: Zinc	1.6	1.7	2.0	-1.4	1.2
Relative age voice broke	1.6	2.5	2.6	1.5	1.6
Mouth/teeth dental problems: Dentures	1.6	2.6	5.3	-0.1	-2.3
Overall health rating	1.6	3.4	6.5	-0.6	-2.5
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	1.9	-1.4	-1.4
Alcohol drinker status: Previous	1.6	1.8	3.7	0.0	-1.9
HbA1C	1.5	1.7	2.6	-1.6	0.8
Hearing difficulty/problems: Yes	1.5	2.4	4.5	-2.1	0.4
Taking other prescription medications	1.5	2.3	3.2	-1.1	-1.8
Nervous feelings	1.5	2.8	4.6	1.0	2.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	1.9	1.4	-1.3
Medication: Lisinopril	1.5	1.9	3.9	2.0	0.1
Ulcerative Colitis (UC)	1.4	2.7	4.3	1.0	2.1
Hand grip strength (left)	1.4	3.7	6.1	-2.5	-1.1
Trunk fat-free mass	1.4	7.8	14.4	-1.1	-3.8
Qualifications: A levels/AS levels or equivalent	1.4	3.0	6.0	2.5	0.2
Trunk predicted mass	1.4	7.9	14.9	-1.0	-3.9
Qualifications: College or University degree	1.4	4.4	8.1	0.8	2.9
Leg pain on walking	1.4	1.8	3.1	0.7	-1.8
Average weekly red wine intake	1.4	2.0	3.3	1.8	0.9
Ever depressed for a whole week	1.4	1.7	1.9	1.3	-1.4
Alzheimer’s Disease (in father)	1.3	1.4	1.8	1.4	-1.0
Bipolar Disorder (2011)	1.3	1.2	1.5	1.2	1.0
Schizophrenia (2014)	1.3	2.9	5.8	0.0	-2.4
Number of incorrect matches in round	1.3	2.2	4.3	2.1	0.1
Pulse wave reflection index	1.3	1.6	2.8	-1.7	-0.7
Number of children fathered	1.3	1.5	1.9	-1.4	-1.0
Number of self-reported non-cancer illnesses	1.3	2.2	3.2	-1.2	-1.8
Hearing aid user	1.3	1.5	2.9	-1.7	-0.3
Ulcerative Colitis	1.2	1.7	3.1	0.5	1.8
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.0	1.7	-0.1
Supplements: Glucosamine	1.2	1.5	2.9	1.7	0.3
Medication: Lansoprazole	1.2	1.3	1.6	-1.3	-1.0
Medication for pain relief, constipation, heartburn	1.2	2.1	3.0	1.1	1.7
Suffer from ‘nerves’	1.2	1.9	3.3	0.7	1.8
Fractured/broken bones in last 5 years	1.2	1.5	2.8	-0.5	1.7
Mean Putamen Volume	1.1	1.2	2.1	-1.4	-0.6
Ever had hysterectomy (womb removed)	1.1	1.2	1.4	1.0	-1.2
Father’s age at death	1.1	1.5	2.2	1.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.2	1.5	-1.2
Birth weight of first child	1.1	1.9	3.8	0.2	2.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.5	1.6	0.3
Medication: Aspirin	1.1	1.5	1.9	-1.4	-1.0
Mood swings	1.1	1.9	2.0	-1.4	1.4
Eye problems/disorders: Cataract	1.1	1.3	1.7	-1.3	-1.0
Basal cell carcinoma (self-reported)	1.1	1.3	2.6	-0.1	-1.6
Alzheimer’s Disease (including proxy)	1.0	1.5	3.0	0.0	-1.7
Breast Cancer	1.0	2.5	4.0	-2.0	-1.0
Ovarian Cancer	1.0	1.4	2.1	-0.8	1.4
Medication: Levothyroxine sodium	1.0	1.6	2.5	0.9	1.6
Diabetes (self-reported)	1.0	1.5	3.0	-0.1	1.7
Time employed in main current job	1.0	1.2	1.5	-1.0	-1.2
Tense / ‘highly strung’	1.0	1.7	2.3	1.0	1.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.2	1.8	-0.1
Medication: Aspirin	1.0	1.3	2.3	-1.5	-0.6
Depressed Affect (Nagel 2018)	0.9	1.8	2.8	-1.7	0.9
Neuroticism (Nagel 2018)	0.9	2.0	3.1	-1.0	1.8
Crohns Disease (2012)	0.9	1.5	2.2	-0.9	1.5
Relative age of first facial hair	0.9	1.9	3.7	-0.3	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.8	-2.0	0.6
Pain all over the body in last month	0.9	0.9	1.9	0.1	-1.4
Pulse wave Arterial Stiffness index	0.9	1.1	1.2	1.1	-0.9
Neck or shoulder pain in last month	0.9	1.3	2.2	-0.7	-1.5
Medication: Omeprazole	0.9	1.1	1.8	-1.4	-0.6
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.5	-0.8	1.2
Diabetes diagnosed by doctor	0.9	1.5	2.8	-0.4	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.9	0.3	-1.4
Average weekly beer plus cider intake	0.9	1.4	2.6	-1.6	-0.4
Bipolar Disorder or Schizophrenia	0.8	2.1	3.8	-0.5	-1.9
Irritable Bowel Disease (IBD)	0.8	1.8	3.5	0.4	1.9
Chronotype (morning person)	0.8	2.0	3.0	1.7	-1.0
Townsend deprivation index at recruitment	0.8	1.1	2.2	1.5	0.3
High blood pressure	0.8	2.3	2.7	1.4	-1.6
Multivitamins +/- minerals	0.8	1.0	1.9	-0.3	1.4
Medication: Atenolol	0.8	1.0	1.9	-0.2	-1.4
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.0	-0.4	1.4
Illnesses of siblings	0.8	1.1	1.4	0.9	1.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.0	-0.1	1.4
Birth weight	0.8	1.7	3.3	-0.3	-1.8
Pulse wave peak to peak time	0.8	1.0	1.0	-1.0	1.0
Back pain experienced in last month	0.8	1.1	2.2	-1.5	0.0
Angina	0.7	1.0	1.9	-1.4	-0.2
Medication: Metformin	0.7	1.0	1.1	0.9	1.0
Stomach or abdominal pain in last month	0.7	0.9	1.3	-1.1	0.7
Falls in the last year	0.7	1.0	2.0	-0.1	-1.4
Depression (self-reported)	0.7	0.8	1.4	-1.2	-0.4
Prospective memory result	0.7	0.9	1.6	0.5	1.3
Length of working week for main job	0.7	0.7	1.5	0.1	-1.2
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.7	1.3	0.0
Comparative body size at age 10	0.7	2.0	2.0	-1.4	-1.4
Number of full brothers	0.7	0.9	1.2	-0.8	1.1
Shortness of breath walking on level ground	0.7	0.8	1.6	0.2	-1.3
Emphysema/chronic bronchitis	0.7	0.7	1.5	-0.1	-1.2
Medication: Blood pressure	0.7	1.3	2.4	-0.5	-1.6
Medication: Allopurinol	0.7	0.9	1.7	-1.3	0.2
Pulse rate, automated reading	0.7	2.2	3.6	0.9	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.5	-1.6	-0.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.5	-0.0	1.2
Alcohol drinker status: Never	0.7	0.8	1.6	1.3	0.2
Age started oral contraceptive pill	0.7	0.9	1.7	1.3	0.2
Diastolic blood pressure, automated reading	0.7	2.1	4.1	0.4	-2.0
Vascular/heart problems diagnosed by doctor	0.7	1.8	2.2	-1.2	1.5
Crohns Disease (2017)	0.6	1.3	1.5	-1.1	1.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	1.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.1	1.0	0.5
Diabetes (mother)	0.6	0.8	0.9	-0.9	0.8
Hand grip strength (right)	0.6	1.5	2.6	-1.6	-0.7
Current tobacco smoking	0.6	1.0	1.8	0.5	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.2	-1.5	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.6	1.3	0.6
Mouth/teeth dental problems	0.6	0.9	1.3	0.7	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.4	-0.0	-1.2
Glaucoma (self-reported)	0.6	0.7	1.4	0.2	-1.2
Gout (self-reported)	0.6	0.9	1.5	-1.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.3	1.2	1.1
Wheeze or whistling in the chest in last year	0.6	1.1	1.2	-1.0	-1.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.2	-0.4	1.1
Hypertension (Self-reported)	0.6	1.7	1.7	1.3	-1.3
Breast cancer (self-reported)	0.6	0.7	1.2	1.1	0.5
Smoking status: Current	0.6	1.0	1.6	0.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	2.7	-0.3	1.6
Financial situation satisfaction	0.6	0.7	1.1	1.0	-0.6
Commuting to job workplace: Public transport	0.6	0.8	0.8	0.9	-0.8
Medication: Paracetamol	0.6	1.0	1.8	1.3	-0.5
Unable to work because of sickness or disability	0.6	0.8	1.0	0.8	-1.0
Pain experienced in last month	0.6	1.0	2.0	1.4	-0.1
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	-0.0	-1.2
Blood White Count	0.5	3.6	4.5	1.6	2.1
Number of treatments/medications taken	0.5	0.9	1.0	-1.0	-0.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.7	-0.8	-0.8
Alcohol usually taken with meals	0.5	0.9	1.5	1.2	-0.5
Hearing difficulty/problems with background noise	0.5	0.8	1.1	-1.0	-0.7
Financial difficulties in last 2 years	0.5	0.7	1.4	0.1	-1.2
Worrier / anxious feelings	0.5	0.9	1.0	-0.9	1.0
Hair/balding pattern: Pattern 3	0.5	0.7	1.1	-0.5	-1.1
Angina (self-reported)	0.5	0.6	1.2	-1.1	-0.2
Family relationship satisfaction	0.5	0.6	1.3	1.1	-0.0
Supplements: Vitamin C	0.5	0.5	1.1	-1.0	-0.2
Illnesses of siblings: Diabetes	0.5	0.7	1.3	-0.2	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.3	-1.1	-0.7
Illnesses of father: None of the above (group 1)	0.5	0.6	0.9	0.6	0.9
Wears glasses or contact lenses	0.5	0.6	0.6	-0.8	0.8
Ever smoked	0.5	0.8	1.3	0.6	1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.6	-0.8	-0.7
Heart disease (siblings)	0.5	0.6	0.9	-0.9	-0.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.3	0.4	1.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.4	0.6	1.2
LDL Cholesterol	0.4	0.7	1.0	-1.0	0.6
Triglycerides	0.4	0.7	1.2	0.4	-1.1
Sensitivity / hurt feelings	0.4	0.7	1.3	1.2	-0.2
Past tobacco smoking	0.4	0.7	1.3	-1.1	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.1	-1.0	-0.5
Age at first live birth	0.4	0.8	1.5	-0.2	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	1.0	-0.0
Loneliness, isolation	0.4	0.6	0.7	-0.8	-0.7
Ever had bowel cancer screening	0.4	0.5	0.9	0.9	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	-0.2	-0.9
Ever taken oral contraceptive pill	0.4	0.5	0.9	1.0	0.2
High cholesterol (Self-reported)	0.4	0.8	1.5	-0.0	1.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	0.2	0.9
Myopia	0.4	0.6	1.3	1.1	0.1
Major Depression (MDD)	0.3	0.3	0.6	0.8	-0.1
Neuroticism (2016)	0.3	0.5	0.9	0.3	0.9
Rheumatoid Arthritis	0.3	0.5	0.7	-0.5	-0.8
Blood Platelet Count	0.3	3.8	7.6	-0.2	2.8
Smoking Status	0.3	0.7	1.2	-0.5	-1.1
Hypothyroidism (self reported)	0.3	0.7	1.2	1.1	0.4
Lung FEV1/FVC ratio	0.3	1.7	2.9	-0.7	-1.7
Systolic blood pressure, automated reading	0.3	0.8	0.9	0.9	-0.9
Severe depression (siblings)	0.3	0.3	0.6	0.8	-0.1
Age when periods started (menarche)	0.3	0.7	1.4	-0.3	1.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.7	0.0	-0.8
Qualifications: None of the above	0.3	0.7	1.1	-1.1	-0.4
Number of live births	0.3	0.5	0.6	0.6	-0.8
Hair/balding pattern: Pattern 4	0.3	0.7	1.0	1.0	-0.7
Peak expiratory flow (PEF)	0.3	0.7	0.9	-0.7	-0.9
Loud music exposure frequency	0.3	0.4	0.7	-0.8	0.2
Exposure to tobacco smoke outside home	0.3	0.4	0.8	0.9	-0.0
Worry too long after embarrassment	0.3	0.5	0.9	1.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.9	-0.0
Illnesses of father: Heart disease	0.3	0.4	0.4	-0.7	0.6
Friendships satisfaction	0.3	0.4	0.6	0.6	-0.7
Asthma (self-reported)	0.3	0.6	0.7	0.7	-0.8
Guilty feelings	0.3	0.4	0.6	-0.8	0.5
Mother’s age at death	0.3	0.4	0.6	0.4	0.8
Medication: Bendroflumethiazide	0.3	0.5	0.9	1.0	0.1
Risk taking	0.3	0.5	0.9	-0.1	1.0
Depression (Nagel 2018)	0.2	0.3	0.6	0.8	-0.3
Neuroticism	0.2	0.5	1.1	0.1	1.0
Medication for hormone replacement therapy	0.2	0.2	0.3	0.6	-0.4
Sitting height	0.2	1.4	1.7	-1.3	1.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	-0.7	0.2
Medication: Ramipril	0.2	0.3	0.4	-0.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.3	-1.1	0.1
Noisy workplace	0.2	0.2	0.4	-0.7	-0.1
Medication: Cholesterol lowering	0.2	0.3	0.4	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.1	-1.1	0.0
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.3	0.6
Breastfed as a baby	0.2	0.2	0.4	0.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.6	0.5
Blood clot in the leg (DVT)	0.2	0.3	0.3	0.5	-0.5
Medication: Paracetamol	0.2	0.3	0.5	0.7	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.7	0.3
Medication: Amlodipine	0.2	0.2	0.4	-0.2	0.7
Smoking status: Previous	0.2	0.3	0.6	0.8	0.1
Qualifications: nursing, teaching	0.2	0.3	0.5	0.7	0.2
Commuting to job workplace: Walk	0.2	0.2	0.2	0.5	0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.3	0.5	-0.5
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.1	0.7
Supplements: Calcium	0.2	0.2	0.4	0.6	-0.2
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.3	-0.4
Age at First Birth	0.1	0.2	0.2	-0.5	-0.4
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.2	0.6
Blood Eosinophil Count	0.1	0.6	0.7	0.8	0.8
Blood Red Count	0.1	1.2	2.5	1.6	0.1
Heel T-Score	0.1	1.2	2.3	0.1	1.5
Waist Hip Ratio (WHR)	0.1	0.5	0.5	0.7	0.7
Systolic Blood Pressure	0.1	0.4	0.4	0.7	0.5
Allergy or Eczema	0.1	0.3	0.5	-0.7	0.1
Cardiovascular Disease	0.1	0.3	0.3	0.6	-0.5
Respiratory disease	0.1	0.3	0.4	-0.4	-0.6
Vitamin and mineral supplements	0.1	0.1	0.3	0.5	-0.1
Pack years adult smoking proportion	0.1	0.1	0.2	-0.5	-0.0
Fed-up feelings	0.1	0.1	0.2	-0.5	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	-0.4	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.3	-0.3
Forced vital capacity (FVC)	0.1	0.2	0.4	-0.6	0.2
Allergy	0.1	0.1	0.2	-0.2	0.5
Fluid intelligence score	0.1	0.2	0.3	0.3	0.5
Neuroticism score	0.1	0.3	0.5	0.7	0.3
Asthma	0.1	0.3	0.3	0.6	-0.5
High blood pressure (siblings)	0.1	0.1	0.1	-0.3	-0.3
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.4	-0.1
Alcohol intake frequency.	0.1	0.2	0.4	-0.2	-0.6
Comparative height size at age 10	0.1	0.5	0.9	1.0	-0.2
Age at last live birth	0.1	0.1	0.1	-0.3	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.6	0.1
Medication for cholesterol	0.1	0.1	0.1	-0.3	-0.2
Mineral and other dietary supplements	0.1	0.2	0.2	0.4	0.4
Miserableness	0.1	0.2	0.4	0.2	-0.6
Medication: Blood pressure	0.1	0.2	0.3	0.5	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.2	-0.5	0.4
Cholesterol lowering medication	0.1	0.1	0.1	-0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	0.3	-0.5
Pack years of smoking	0.1	0.1	0.1	-0.4	0.1
Bipolar Disorder (2018)	0.0	0.1	0.1	-0.2	0.3
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.2	-0.1
HDL Cholesterol	0.0	0.0	0.1	0.1	0.3
Height	0.0	0.1	0.2	-0.4	0.1
Lung FVC	0.0	0.2	0.3	0.2	0.6
Hair Pigment	0.0	1.4	2.2	-0.8	-1.5
Tanning	0.0	0.4	0.9	-0.9	0.1
Average weekly spirits intake	0.0	0.0	0.0	-0.2	-0.1
Medication: Co-codamol	0.0	0.0	0.0	-0.1	0.2
Diabetes (father)	0.0	0.0	0.0	0.1	0.0
Serious illness, injury or assault to yourself	0.0	0.1	0.1	-0.1	-0.3
Medication: Simvastatin	0.0	0.1	0.1	0.3	0.2
Lung cancer (father)	0.0	0.0	0.0	-0.0	-0.1
Standing height	0.0	0.2	0.5	-0.7	0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	-0.3	0.1
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	0.2	0.0
Average weekly champagne plus white wine intake	0.0	0.1	0.1	-0.3	-0.1
Irritability	0.0	0.1	0.1	-0.3	-0.2

Hub : Genes

EIF5A2

Models

Trait associations