Hub : Genes

EIF5B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.1760	0.0860	0.00043	0.130	NA	0.121	NA	0.113	2.0e-06	NA	4.7e-06	NA	9.5e-06
2	TCGA	Colon Adenocarcinoma	0.0850	0.0490	0.00037	0.062	0.046	0.026	NA	0.041	1.8e-04	0.00120	1.2e-02	NA	2.1e-03
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0573	0.0323	0.00410	0.005	0.024	0.025	NA	0.018	7.7e-02	0.00090	7.1e-04	NA	3.3e-03
4	TCGA	Thyroid Carcinoma	0.0910	0.0640	0.00021	0.042	0.045	0.054	NA	0.040	6.0e-05	0.00003	5.3e-06	NA	8.0e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	6.0	9.5	23.0	-2.9	4.8	1.4	-2.2
Bipolar Disorder or Schizophrenia	1.0	2.5	7.4	-1.0	2.7	0.8	-1.0
Depressed Affect (Nagel 2018)	0.6	1.2	3.3	-0.1	0.6	-1.8	-1.1
Depression (Nagel 2018)	1.2	1.9	5.5	-0.5	1.2	-0.5	-2.3
Intelligence (Savage-Jansen 2018)	1.1	3.5	7.3	0.4	-2.7	0.6	2.5
Neuroticism (Nagel 2018)	0.7	1.6	5.8	0.5	-0.0	-2.4	-0.4
Schizophrenia (2018)	0.2	0.4	1.2	1.1	-0.4	0.1	0.6
Schizophrenia vs Biploar Disorder	6.2	8.2	17.3	3.5	-4.2	-1.6	0.6
Worry (Nagel 2018)	1.6	3.4	6.3	-0.1	-2.4	-2.5	1.2
Alzheimer’s Disease (in mother)	0.5	0.6	1.2	-1.1	0.4	-0.3	-0.9
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.7	-0.1	-0.4	0.1
Alzheimer’s Disease (including proxy)	0.3	0.5	1.0	-0.1	0.6	-0.7	-1.0
Crohns Disease (2017)	0.1	0.2	0.4	-0.3	0.1	0.6	0.5
Irritable Bowel Disease (IBD)	0.2	0.4	1.3	1.1	-0.4	-0.2	0.2
Ulcerative Colitis (UC)	0.9	1.8	3.6	1.9	-1.4	-1.1	0.5
Major Depression (MDD)	4.1	5.0	13.2	-1.1	2.4	-0.1	-3.6
Reaction Time	0.5	1.0	1.8	-0.7	-1.4	0.1	1.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.9	0.1	-2.0	0.3	1.2
Breast Cancer	0.5	1.2	2.8	-0.5	-0.4	-1.7	-1.3
Ovarian Cancer	0.6	0.8	1.6	0.7	-1.0	0.4	1.3
Prostate Cancer	0.6	0.8	1.2	1.1	0.2	1.0	1.0
Age at First Birth	0.3	0.4	1.5	0.0	-0.3	-1.2	0.2
Bipolar Disorder (2011)	5.1	4.9	15.1	-2.1	3.9	-0.1	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	1.7	-0.8	-1.2	-1.3	0.2
Coronary Artery Disease (CAD)	1.1	1.4	1.8	-1.3	1.2	-0.7	-1.3
Crohns Disease (2012)	0.5	0.9	1.8	-1.3	0.4	1.2	-0.1
Mean Putamen Volume	0.7	0.8	2.2	0.8	0.1	1.5	0.4
Fasting Glucose	0.5	0.6	1.2	1.1	-0.3	0.9	-0.4
HbA1C	0.2	0.3	0.4	-0.5	-0.5	-0.6	-0.3
HDL Cholesterol	0.3	0.5	1.3	-0.7	1.1	-0.3	-0.3
LDL Cholesterol	0.2	0.3	0.9	-0.1	0.1	-0.6	-1.0
Lupus	0.1	0.2	0.4	0.2	0.5	-0.2	0.6
Neuroticism (2016)	0.4	0.6	1.4	0.9	-0.4	-1.2	-0.1
Primary Biliary Cirrhosis	0.9	1.3	2.2	1.0	-1.5	-1.4	-0.2
Rheumatoid Arthritis	0.9	1.2	2.5	-1.2	1.6	-0.1	-0.8
Schizophrenia (2014)	0.2	0.4	0.9	1.0	0.2	-0.6	-0.7
Triglycerides	0.3	0.5	1.0	0.4	-0.8	-0.4	1.0
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.2	0.6	-1.4	-1.5	0.1
Ulcerative Colitis	0.7	1.0	2.6	1.6	-0.9	-0.6	-0.6
Blood Eosinophil Count	0.8	6.0	20.2	4.5	-1.9	-0.5	-0.4
Blood Platelet Count	0.1	0.7	1.8	-0.1	-0.7	1.4	0.7
Blood Red Count	0.3	2.8	5.6	0.1	2.4	-0.5	-2.3
Blood White Count	0.9	6.5	13.1	-1.4	3.6	2.1	-2.6
Heel T-Score	1.4	11.5	19.7	-1.7	4.1	4.4	-2.6
BMI	1.5	8.9	24.3	-0.4	3.0	-1.5	-4.9
Height	0.7	12.6	20.4	3.5	-4.5	-2.2	3.5
Waist Hip Ratio (WHR)	2.0	9.2	17.6	1.8	-4.2	-0.7	3.9
Systolic Blood Pressure	0.1	0.7	1.3	0.9	0.6	1.1	-0.7
Smoking Status	4.6	11.1	16.8	-3.4	4.1	3.5	-1.9
Allergy or Eczema	0.2	0.6	2.1	0.4	-1.4	-0.3	0.2
Cardiovascular Disease	0.4	1.4	2.6	-0.2	1.6	-1.1	-1.4
Hypothyroidism (self reported)	2.1	4.9	10.0	-0.7	3.2	0.8	-2.9
Respiratory disease	1.3	2.9	4.5	2.1	-1.6	-2.0	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.0	-0.2	-1.4	0.1	0.2
Lung FEV1/FVC ratio	2.4	12.3	28.4	-3.5	5.3	2.3	-1.9
Lung FVC	0.3	1.4	2.6	0.8	1.6	0.2	-1.6
Neuroticism	1.0	2.5	9.5	0.2	-0.3	-3.1	-0.4
Chronotype (morning person)	0.6	1.4	4.5	-2.1	0.5	0.6	0.7
Hair Pigment	0.2	4.8	10.0	-1.4	3.2	0.3	-2.6
Tanning	0.0	0.2	0.6	-0.3	0.3	-0.4	0.8
Hand grip strength (left)	1.1	2.9	6.2	1.1	-2.5	-1.3	1.7
Number of treatments/medications taken	0.9	1.6	2.5	-0.9	1.6	1.1	-1.3
Average weekly spirits intake	1.3	1.6	2.3	-1.0	1.2	-1.3	-1.5
Sensitivity / hurt feelings	0.5	0.8	2.2	0.3	-0.8	-1.5	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	0.4	-0.1	-0.9	-0.5
Hearing difficulty/problems: Yes	1.3	2.0	5.1	1.6	-2.3	-0.2	0.7
Relative age of first facial hair	0.1	0.1	0.3	0.2	-0.2	0.6	-0.3
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.5	0.2	1.9	0.9	-1.2
Ever used hormone-replacement therapy (HRT)	1.0	1.2	1.7	1.2	-1.3	-1.3	-0.1
Ever had hysterectomy (womb removed)	1.5	1.7	3.4	-0.8	1.7	-0.1	-1.8
Systolic blood pressure, automated reading	0.5	1.6	6.1	-0.3	0.3	-0.0	-2.5
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	-1.3	1.0	0.8	-0.5
Angina	1.3	1.7	2.9	0.5	1.2	1.7	-1.5
Medication for hormone replacement therapy	0.2	0.3	0.7	0.4	-0.8	0.3	-0.3
Vitamin and mineral supplements	0.6	0.8	1.8	0.9	1.4	0.0	-0.7
Supplements: Zinc	0.8	0.9	2.2	0.6	-1.5	0.4	0.9
Medication: Co-codamol	0.3	0.4	1.1	-0.5	0.3	1.1	-0.4
Medication: Metformin	0.4	0.5	1.0	0.1	-1.0	-0.4	-1.0
Diabetes (father)	0.8	0.9	2.0	1.4	0.2	0.7	-1.1
Diabetes (mother)	0.8	1.0	2.1	-0.6	-0.3	1.5	1.2
Severe depression (siblings)	1.9	2.1	7.5	0.8	0.6	-2.7	-0.2
Pack years adult smoking proportion	0.3	0.5	1.3	0.8	0.1	0.0	-1.1
Impedance of leg (right)	0.3	1.6	3.3	-0.8	0.1	1.6	1.8
Leg fat-free mass (left)	0.6	3.1	6.7	1.9	-0.6	-2.6	-1.2
Trunk fat percentage	0.7	2.6	8.2	0.1	1.4	-0.6	-2.9
Hand grip strength (right)	1.8	4.9	7.1	2.7	-2.7	-1.5	1.7
Townsend deprivation index at recruitment	0.1	0.2	0.6	0.1	0.8	0.4	0.2
Current tobacco smoking	4.2	6.8	9.4	-2.6	3.0	3.1	-1.6
Average weekly fortified wine intake	0.5	0.6	1.3	-0.9	-1.2	0.3	-0.1
Maternal smoking around birth	1.0	1.5	4.7	0.4	2.2	0.4	-1.0
Fed-up feelings	1.1	2.0	6.1	-0.6	1.2	-2.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	5.7	-0.2	-0.4	-0.7	-2.4
Relative age voice broke	0.2	0.3	0.9	-0.2	0.9	0.3	-0.4
Taking other prescription medications	0.6	0.9	2.7	-0.0	1.0	1.7	0.1
Age when periods started (menarche)	0.5	1.1	2.5	0.9	0.5	1.0	1.6
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	5.8	-0.5	2.1	-0.7	-2.4
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	7.7	0.0	2.7	0.3	-2.8
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	6.0	-0.3	1.8	-0.1	-2.5
Qualifications: CSEs or equivalent	1.7	2.3	5.2	0.4	2.3	-1.3	-1.5
Serious illness, injury or assault to yourself	3.9	4.8	7.6	-1.2	2.8	1.9	-2.5
High blood pressure	0.1	0.3	0.5	-0.1	0.6	-0.7	-0.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	0.8	-0.7	-0.2	-0.2
Multivitamins +/- minerals	0.7	0.9	1.4	-0.9	-1.2	0.0	1.1
Stomach or abdominal pain in last month	0.9	1.1	2.3	-0.0	1.4	0.3	-1.5
Supplements: Glucosamine	0.6	0.8	2.7	-0.1	0.6	-1.6	-0.3
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	6.2	-0.8	1.5	-0.3	-2.5
Medication: Atenolol	0.4	0.5	1.6	-1.3	0.6	-0.0	-0.1
Medication: Levothyroxine sodium	1.7	2.8	6.6	0.0	2.6	-1.1	-1.9
Sitting height	1.1	8.1	11.6	3.0	-3.4	-2.8	2.0
Chronic bronchitis/emphysema (father)	0.1	0.2	0.6	-0.1	0.1	0.2	-0.8
High blood pressure (mother)	0.4	0.6	1.1	-1.1	0.7	-0.8	-0.0
Body mass index (BMI)	1.6	6.9	18.1	-0.2	2.7	-1.4	-4.3
Impedance of leg (left)	0.4	2.1	3.8	-1.0	-0.1	1.9	1.9
Leg predicted mass (left)	0.6	3.1	6.7	2.0	-0.6	-2.6	-1.2
Trunk fat mass	0.6	2.7	8.1	0.6	1.1	-1.1	-2.9
Waist circumference	0.5	1.9	2.6	1.6	-0.5	-1.6	-1.5
Number of incorrect matches in round	0.7	1.2	2.1	-1.4	0.4	-1.2	1.0
Past tobacco smoking	2.6	4.8	8.8	1.9	-3.0	-2.2	1.4
Alcohol usually taken with meals	0.3	0.4	1.0	-0.4	-0.7	-0.4	1.0
Nervous feelings	1.0	1.8	4.6	0.8	-0.7	-2.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.8	1.3	0.2	-1.9	0.2
Hearing difficulty/problems with background noise	1.8	2.8	7.8	2.8	-1.1	-0.8	-1.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.2	0.8	0.1	-0.6
Had menopause	3.9	4.9	16.1	0.5	-4.0	-0.1	1.8
Had other major operations	0.3	0.4	0.7	0.8	0.4	0.5	-0.7
Forced vital capacity (FVC)	0.3	1.1	4.0	2.0	-0.5	-0.0	0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	9.7	-0.4	3.1	0.3	-2.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.5	0.7	-0.6	0.5	0.3
Qualifications: None of the above	1.8	3.9	8.1	-1.8	2.8	0.5	-2.0
Financial difficulties in last 2 years	0.5	0.6	1.1	0.2	-1.0	1.0	-0.6
Mouth/teeth dental problems	0.4	0.6	1.8	-0.3	-0.3	-1.4	-0.5
Heart attack	0.5	0.6	2.0	0.5	0.4	1.4	-0.1
Allergy	0.3	0.7	1.2	-0.8	1.1	0.9	0.2
Pain all over the body in last month	3.5	3.8	6.8	2.6	-2.3	-0.3	1.7
Diabetes (self-reported)	0.3	0.5	1.5	-0.2	-1.2	0.7	-0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.2	1.8	-0.8	-0.2	0.8
Medication: Ramipril	0.3	0.3	0.6	0.3	-0.8	-0.3	0.8
Medication: Simvastatin	0.7	1.0	2.2	-1.2	1.5	0.4	-0.3
Fluid intelligence score	1.6	3.3	6.7	0.4	-2.6	1.1	2.2
Illnesses of siblings	0.8	1.1	2.6	1.2	-0.2	1.6	-0.4
Neuroticism score	0.6	1.4	4.9	0.2	-0.0	-2.2	-0.7
Weight	0.6	3.1	5.8	1.4	0.2	-2.1	-2.4
Impedance of arm (right)	1.1	5.1	7.8	-0.4	-2.2	2.8	2.8
Arm fat percentage (right)	1.4	5.6	15.6	-0.6	2.5	-0.5	-4.0
Trunk fat-free mass	0.5	2.8	6.6	1.8	-0.1	-2.6	-1.3
Hip circumference	1.0	4.2	8.9	1.9	1.1	-1.6	-3.0
Time employed in main current job	0.3	0.4	1.4	0.1	-1.2	0.2	-0.3
Alcohol intake versus 10 years previously	0.6	1.0	1.7	0.5	1.1	1.3	-0.8
Father’s age at death	0.0	0.1	0.2	-0.0	0.2	0.4	0.2
Worrier / anxious feelings	1.6	3.1	8.9	-0.1	-3.0	-1.6	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	4.7	1.4	1.0	-2.2	-1.9
Falls in the last year	0.6	0.8	2.9	1.7	0.4	-0.2	0.2
Hair/balding pattern: Pattern 3	0.6	0.9	3.4	0.2	-1.8	-0.3	0.2
Number of live births	0.3	0.4	0.9	-0.3	0.3	0.6	-1.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	0.9	0.9	0.8	0.6	-0.4
Pulse rate	1.5	2.5	4.4	1.2	-2.1	-1.7	0.9
Happiness	1.3	1.6	2.2	1.2	-1.3	-1.0	1.5
Noisy workplace	0.7	0.9	2.2	0.1	1.0	0.5	-1.5
Qualifications: A levels/AS levels or equivalent	2.9	6.3	16.1	1.1	-4.0	0.8	2.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.4	0.5	0.6	-0.1
Mouth/teeth dental problems: Dentures	1.4	2.3	3.8	-1.4	2.0	1.1	-1.5
Asthma	0.4	0.8	1.5	0.5	-1.2	-1.2	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	5.1	-2.3	1.4	0.5	-1.2
Medication: Cholesterol lowering	0.8	1.2	3.0	-0.1	1.7	0.6	-1.1
Depression (self-reported)	0.7	0.8	2.4	-0.6	0.6	-1.6	0.3
Medication: Lansoprazole	0.5	0.5	1.8	0.1	0.1	-0.5	-1.4
Prospective memory result	1.2	1.5	2.4	-1.4	1.1	-0.6	-1.6
Lung cancer (father)	1.2	1.4	3.8	-0.2	1.0	0.8	-2.0
Illnesses of mother	0.9	1.1	2.4	0.4	-0.8	1.1	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.0	-0.3	1.4	0.6	-0.2
Pulse wave Arterial Stiffness index	1.0	1.1	2.0	1.2	-0.9	-1.4	-0.4
Impedance of arm (left)	1.2	5.4	8.9	0.1	-2.9	2.0	3.0
Arm fat mass (right)	1.2	4.8	14.1	0.5	1.8	-1.3	-3.8
Trunk predicted mass	0.5	2.8	6.6	1.8	-0.1	-2.6	-1.3
Standing height	1.2	12.3	23.3	3.4	-4.8	-1.8	3.4
Length of working week for main job	2.0	2.2	5.1	1.6	-2.3	-1.0	0.6
Exposure to tobacco smoke at home	1.9	2.1	6.4	-1.1	0.1	0.8	-2.5
Breastfed as a baby	0.8	1.0	1.7	1.3	-1.0	-1.1	-0.0
Tense / ‘highly strung’	0.5	0.9	1.7	0.4	-0.9	-0.9	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.6	-0.3	1.3	-0.4	-0.3
Hair/balding pattern: Pattern 4	0.8	1.9	3.5	-1.9	1.8	-0.1	-1.0
Birth weight of first child	0.1	0.2	0.8	0.3	0.0	0.9	0.0
Peak expiratory flow (PEF)	0.2	0.4	1.4	-0.2	0.4	1.2	0.0
Pulse wave reflection index	0.2	0.2	0.5	0.7	-0.2	0.1	-0.5
Ever highly irritable/argumentative for 2 days	1.8	2.1	6.5	1.3	-0.2	-2.5	0.5
Loud music exposure frequency	1.6	1.8	4.2	0.8	2.0	-1.1	-1.0
Qualifications: O levels/GCSEs or equivalent	6.1	9.7	23.5	2.4	-4.8	-0.5	3.0
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.4	1.6	-1.8	-0.4	1.5
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.1	0.1	-0.7	-0.8
Medication: Paracetamol	0.3	0.5	1.2	0.3	-0.1	0.8	-1.1
Headache pain in last month	2.8	4.8	8.8	-1.1	2.9	0.9	-3.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.7	-0.9	-0.3	0.2
Glaucoma (self-reported)	1.0	1.1	2.8	-0.5	1.1	1.7	-0.6
Gout (self-reported)	1.3	1.8	4.5	1.3	-0.9	-2.1	-0.7
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	5.0	-0.5	2.2	-0.1	-2.2
Medication: Amlodipine	0.2	0.3	0.6	0.0	0.5	0.8	-0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.7	1.3	-0.2	-1.0	0.4
Birth weight	0.2	0.4	1.4	0.0	-0.1	1.2	-0.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.5	0.0	1.2	-0.1	-1.6
High blood pressure (siblings)	0.8	1.2	2.9	-1.0	0.8	-1.7	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.2	0.7	0.8	0.4	0.2	-0.1
Body fat percentage	1.1	4.4	12.5	-0.2	2.1	-0.8	-3.5
Leg fat percentage (right)	2.3	8.4	20.5	-0.6	3.4	-1.0	-4.5
Arm fat-free mass (right)	0.7	3.6	7.7	1.8	0.1	-2.8	-1.8
Exposure to tobacco smoke outside home	0.4	0.5	1.4	-0.1	-0.8	0.2	-1.2
Comparative body size at age 10	0.1	0.3	1.1	0.0	-0.1	-0.3	-1.1
Number of full brothers	0.7	0.8	1.6	-1.3	0.6	1.1	0.2
Worry too long after embarrassment	1.4	2.3	4.2	1.2	0.9	-2.1	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.4	-1.3	1.8	0.1	-0.1
Wheeze or whistling in the chest in last year	0.7	1.2	2.1	1.5	-0.3	-1.4	-0.9
Number of children fathered	1.1	1.2	2.4	-0.8	1.3	0.5	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.7	1.6	-1.4	-1.1	0.4
Age at first live birth	1.2	2.1	5.0	0.4	-2.2	0.3	1.8
Pulse wave peak to peak time	0.6	0.8	1.7	-0.9	0.6	1.3	0.5
Health satisfaction	1.3	1.7	4.7	1.3	0.2	-0.7	-2.2
Shortness of breath walking on level ground	0.3	0.3	0.5	-0.1	-0.5	-0.7	0.7
Qualifications: College or University degree	2.5	8.0	20.3	1.5	-4.5	-0.1	3.0
Eye problems/disorders: None of the above	0.8	0.9	2.2	0.7	-0.0	-1.5	-0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	0.4	-0.2	0.8	0.7
Emphysema/chronic bronchitis	0.4	0.5	1.5	0.6	0.3	-1.2	-0.2
Medication for pain relief, constipation, heartburn	2.1	3.6	8.8	1.7	-1.5	-0.2	3.0
Neck or shoulder pain in last month	1.1	1.6	4.8	-0.0	2.2	0.2	-1.3
Medication: Blood pressure	0.1	0.2	0.3	-0.5	0.4	-0.5	0.2
Angina (self-reported)	1.3	1.7	3.3	0.3	1.3	1.8	-1.4
Migraine (self-reported)	0.3	0.4	0.9	-0.6	1.0	0.6	-0.4
Medication: Ibuprofen	1.5	1.8	3.5	-1.9	1.3	0.7	-1.2
Medication: Allopurinol	1.1	1.5	4.4	0.5	-0.9	-2.1	-0.7
Medication: Omeprazole	0.5	0.6	1.4	0.4	0.8	-1.2	-0.5
Medication: Seretide 50 evohaler	1.4	1.6	4.2	1.1	-2.1	-0.4	1.0
Mean time to correctly identify matches	0.8	1.5	4.4	0.2	-2.1	-0.7	1.0
Heart disease (mother)	2.1	2.6	6.4	-1.1	1.6	-0.4	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.4	0.0	-0.0	-0.3	1.6
Whole body fat mass	0.9	3.8	10.6	0.7	1.5	-1.3	-3.3
Leg fat mass (right)	1.7	6.6	18.0	0.1	2.5	-1.4	-4.2
Arm predicted mass (right)	0.7	3.3	8.4	1.6	-0.0	-2.9	-1.6
Pulse rate, automated reading	0.3	1.1	1.7	0.6	-1.3	-1.3	0.8
Alcohol intake frequency.	1.0	2.3	5.1	-0.5	1.9	0.2	-2.2
Comparative height size at age 10	0.7	4.0	10.4	1.1	-3.2	-1.6	1.3
Number of full sisters	1.3	1.6	3.7	1.9	-1.5	0.4	0.4
Suffer from ‘nerves’	0.6	0.9	1.7	-0.1	-1.2	-1.3	0.7
Overall health rating	1.8	3.8	6.3	2.5	-1.4	-2.3	-1.3
Chest pain or discomfort	3.3	4.7	11.9	-0.6	2.4	1.1	-3.5
Had major operations	0.2	0.2	0.4	0.6	0.2	0.3	-0.5
Age at last live birth	0.8	1.2	3.0	-0.4	-1.7	0.2	1.2
Family relationship satisfaction	1.4	1.8	3.0	-0.1	-1.7	1.7	1.0
Leg pain on walking	0.4	0.5	1.0	1.0	-0.1	0.7	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.8	-0.9	1.9	0.1	-1.0
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.2	-1.5	0.3	-0.3	-1.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.9	-0.2	-0.2	-0.9	-0.6
Medication: Aspirin	0.3	0.4	1.3	0.7	0.2	0.1	-1.1
Supplements: Vitamin C	0.6	0.7	1.2	-0.9	1.1	0.7	-0.6
Knee pain experienced in last month	3.4	5.2	10.1	-0.6	3.2	1.1	-3.0
Hypertension (Self-reported)	0.1	0.4	0.7	0.1	0.5	-0.8	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.2	-0.1	0.3	-1.5	-1.3
Illnesses of father: Heart disease	0.6	0.8	2.0	-0.6	-0.4	-0.8	-1.4
Illnesses of siblings: Diabetes	2.1	2.6	8.0	-2.8	1.3	0.9	0.1
Smoking status: Previous	2.8	4.1	8.2	-1.7	2.9	1.4	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	4.9	2.2	-1.3	-1.8	1.4
Whole body fat-free mass	0.6	3.2	6.8	2.0	-0.4	-2.6	-1.3
Leg fat-free mass (right)	0.6	3.0	5.6	2.1	-1.1	-2.4	-0.8
Arm fat percentage (left)	1.4	5.4	15.6	-0.5	2.4	-0.6	-4.0
Average weekly red wine intake	0.9	1.4	2.8	1.1	-1.7	-0.7	1.0
Handedness (chirality/laterality): Left-handed	2.2	2.7	5.1	1.5	-2.2	-1.2	1.4
Mood swings	0.9	1.7	3.5	-0.6	0.4	-1.9	-1.6
Loneliness, isolation	0.2	0.3	0.8	0.3	-0.6	-0.9	0.2
Long-standing illness, disability or infirmity	1.2	1.9	6.8	2.6	-0.6	-0.5	-0.3
Ever had bowel cancer screening	0.5	0.6	1.0	-1.0	0.0	0.8	-0.9
Diabetes diagnosed by doctor	0.2	0.4	0.7	-0.2	-0.3	0.8	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.4	1.6	0.2	0.6	-0.2
Friendships satisfaction	0.7	0.8	1.3	0.4	-1.1	1.0	0.9
Qualifications: nursing, teaching	0.3	0.4	0.9	-0.7	-0.9	-0.2	-0.5
Commuting to job workplace: Walk	0.4	0.4	0.7	0.8	-0.3	0.7	-0.7
Eye problems/disorders: Cataract	0.9	1.0	3.4	-0.2	1.9	0.6	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.7	-0.2	-0.2	1.7	1.4
Medication for cholesterol	0.7	1.1	2.9	-0.5	0.2	1.0	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	-0.3	0.6	-0.5	-1.1
Back pain experienced in last month	0.7	1.0	3.4	-0.1	0.4	-1.9	-0.5
Mineral and other dietary supplements	0.4	0.5	1.8	0.1	0.1	1.4	0.3
Breast cancer (self-reported)	1.0	1.2	3.3	1.8	-1.0	0.2	-0.8
Asthma (self-reported)	0.5	0.9	1.7	0.6	-1.3	-1.2	-0.1
Osteoporosis (self-reported)	1.0	1.2	2.0	-1.2	-0.8	0.8	1.4
Osteoarthritis (self-reported)	2.0	2.6	6.8	-0.2	1.9	-0.1	-2.6
Medication: Aspirin	0.3	0.4	0.8	0.8	0.4	0.2	-0.9
Medication: Gliclazide	0.5	0.5	1.2	0.7	-1.1	0.1	-0.7
Illnesses of father: None of the above (group 1)	0.7	0.9	3.4	0.3	0.1	0.3	1.9
Smoking status: Current	5.0	7.9	12.1	-2.9	3.1	3.5	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.7	6.4	-1.2	2.5	0.8	-2.5
Whole body water mass	0.5	2.9	6.6	1.8	-0.2	-2.6	-1.4
Leg predicted mass (right)	0.5	2.9	5.4	2.0	-1.1	-2.3	-0.8
Arm fat mass (left)	1.1	4.5	13.2	0.4	1.7	-1.3	-3.6
Number of self-reported non-cancer illnesses	0.5	0.9	1.9	0.2	1.4	-0.6	-1.1
Average weekly champagne plus white wine intake	5.2	7.2	19.0	0.7	-3.0	-0.4	4.4
Miserableness	1.3	2.2	4.2	0.2	1.4	-1.6	-2.0
Guilty feelings	2.1	3.2	4.9	-1.7	2.2	-0.5	-2.2
Wears glasses or contact lenses	0.5	0.6	1.6	0.3	-0.7	-0.4	1.3
Ever taken oral contraceptive pill	1.5	1.7	6.6	-0.1	2.6	0.5	0.0
Hearing aid user	0.4	0.5	0.7	-0.9	-0.5	-0.8	-0.6
Mother’s age at death	1.3	1.6	4.6	-0.4	-2.1	-0.2	1.3
Financial situation satisfaction	0.4	0.5	0.8	0.3	0.9	0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.6	-1.1	0.5	0.8	1.3
Commuting to job workplace: Public transport	4.5	5.4	14.2	1.6	-2.2	-0.3	3.8
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	-1.0	0.9	0.8	-1.5
Medication: Blood pressure	0.3	0.6	1.6	0.2	0.2	-1.3	-0.9
Pain type(s) experienced in last month: Hip pain	3.5	4.4	8.7	-0.4	2.7	1.2	-3.0
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.3	-1.0	1.1	0.5	-1.2
High cholesterol (Self-reported)	0.4	0.8	2.1	-1.0	1.4	0.2	-0.2
Medication: Bendroflumethiazide	0.3	0.4	1.0	-0.5	0.4	-0.5	-1.0
Medication: Paracetamol	0.6	0.9	2.5	0.3	-0.0	0.9	-1.6
Medication: Lisinopril	0.1	0.1	0.1	-0.4	-0.2	0.3	-0.0
Medication: Atorvastatin	1.0	1.2	3.0	-0.3	1.7	-0.4	-1.2
Illnesses of father: High blood pressure	0.5	0.6	1.0	-1.0	0.9	-0.6	0.2
Alcohol drinker status: Never	0.1	0.2	0.6	-0.0	0.0	-0.2	-0.8
Ever smoked	2.0	3.5	9.4	-1.7	1.4	3.1	-0.1
Basal metabolic rate	0.6	3.3	7.0	1.9	-0.2	-2.6	-1.6
Leg fat percentage (left)	2.0	7.2	17.5	-0.7	3.2	-0.8	-4.2
Arm fat-free mass (left)	0.6	3.2	7.2	1.7	0.3	-2.7	-1.7
Number of operations (self-reported)	0.3	0.4	1.1	0.3	0.4	1.0	-0.7
Average weekly beer plus cider intake	0.8	1.2	3.4	0.1	-1.9	-0.2	1.2
Irritability	0.6	1.1	3.1	1.8	-0.5	-0.6	0.8
Risk taking	0.3	0.5	0.8	0.2	0.9	0.8	0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	-1.0	-0.1	0.8	-0.5
Fractured/broken bones in last 5 years	0.6	0.8	1.8	-1.3	0.8	-0.6	-0.7
Age started oral contraceptive pill	1.7	2.2	3.8	1.8	-1.9	-1.2	-0.6
Diastolic blood pressure, automated reading	0.7	2.1	7.1	0.6	0.7	-0.6	-2.7
Ever depressed for a whole week	0.2	0.3	0.9	0.9	-0.1	-0.4	-0.3
Unable to work because of sickness or disability	0.6	0.8	2.2	0.2	0.9	0.3	-1.5
Commuting to job workplace: Cycle	0.4	0.5	0.9	0.1	0.5	0.9	1.0
Myopia	0.9	1.3	2.8	0.9	-1.3	0.0	1.7
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.5	-0.3	0.2	0.8
Cholesterol lowering medication	0.5	0.7	1.3	0.1	0.9	-0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.4	1.2	0.4	-1.8	-0.6
Pain experienced in last month	2.1	3.5	7.0	-0.1	-2.6	-0.5	2.6
Supplements: Calcium	2.1	2.4	4.0	1.7	-2.0	-1.2	1.1
Basal cell carcinoma (self-reported)	0.7	0.8	2.0	-0.5	-1.4	0.1	0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.7	0.7	0.1	1.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	-0.4	-0.1	-0.4	-0.7
Heart disease (siblings)	0.4	0.5	1.3	-0.1	-0.1	1.1	-0.7
Alcohol drinker status: Previous	0.8	0.9	2.9	-0.1	0.4	-1.7	0.7
Pack years of smoking	0.4	0.5	1.4	0.8	0.1	-0.2	-1.2
Impedance of whole body	0.9	4.3	8.5	-0.4	-1.9	2.3	2.9
Leg fat mass (left)	1.4	5.7	15.3	0.3	2.3	-1.4	-3.9
Arm predicted mass (left)	0.6	3.2	6.5	1.4	0.5	-2.5	-2.1