Hub : Genes

EMILIN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.168	0.0460	5.8e-05	0.027	0.048	0.078	0.085	0.083	3.0e-04	1.4e-06	8.5e-10	1.4e-10	2.5e-10
2	GTEx	Cells Transformed fibroblasts	0.380	0.0770	6.4e-06	0.146	NA	0.139	NA	0.143	4.7e-11	NA	1.4e-10	NA	6.9e-11
3	YFS	Blood	0.269	0.0335	0.0e+00	0.153	0.122	0.167	0.160	0.167	9.0e-48	1.1e-37	2.2e-52	7.7e-50	2.6e-52
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.162	0.0600	1.0e-03	-0.005	0.024	0.013	NA	-0.005	8.8e-01	1.5e-02	5.7e-02	NA	7.7e-01
5	TCGA	Ovarian Serous Cystadenocarcinoma	0.087	0.0380	4.0e-03	0.005	0.037	0.023	NA	0.011	1.3e-01	1.6e-03	9.6e-03	NA	5.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.7	-0.1	0.7	-0.6	-0.8	0.0
Bipolar Disorder or Schizophrenia	0.2	0.4	0.9	0.1	0.9	-0.4	0.7	-0.7
Depressed Affect (Nagel 2018)	1.1	2.4	8.2	-1.4	0.3	2.9	1.3	-0.0
Depression (Nagel 2018)	0.3	0.4	1.5	-0.3	-0.3	0.6	-0.0	-1.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.1	0.4	0.5	0.1	0.1	-1.1
Neuroticism (Nagel 2018)	0.7	1.7	5.1	-1.3	0.5	2.3	1.2	-0.0
Schizophrenia (2018)	0.3	0.6	1.5	0.6	0.4	-0.2	1.2	-1.1
Schizophrenia vs Biploar Disorder	0.2	0.2	1.0	0.3	-1.0	0.2	0.0	0.0
Worry (Nagel 2018)	0.5	1.1	2.5	-0.9	1.2	0.7	1.6	-0.5
Alzheimer’s Disease (in mother)	0.6	0.7	3.2	-1.8	0.2	-0.2	0.5	-0.3
Alzheimer’s Disease (in father)	2.6	2.8	7.0	2.0	-0.7	-2.6	-1.6	0.3
Alzheimer’s Disease (including proxy)	0.7	0.9	2.0	-0.8	-1.1	-1.4	-0.4	0.8
Crohns Disease (2017)	0.4	0.8	3.0	0.2	-0.5	-1.7	-0.7	0.5
Irritable Bowel Disease (IBD)	0.5	1.1	3.7	1.0	0.1	-1.9	-0.8	-0.5
Ulcerative Colitis (UC)	0.5	1.0	2.1	0.7	0.4	-1.4	-1.3	-0.8
Major Depression (MDD)	0.9	1.1	2.7	-1.3	0.3	1.1	1.6	-0.4
Reaction Time	0.4	0.8	2.3	0.6	0.4	0.2	1.5	-1.0
Verbal and Numeric Reasoning (VNR)	1.4	3.4	7.7	-2.7	0.3	2.8	1.2	0.9
Breast Cancer	0.7	1.8	6.0	0.7	2.5	1.0	1.0	-0.6
Ovarian Cancer	0.3	0.3	0.8	-0.1	0.5	-0.8	-0.0	-0.9
Prostate Cancer	2.0	2.8	6.2	1.5	0.3	-2.5	-2.2	-1.1
Age at First Birth	1.8	2.6	4.4	-1.1	-1.3	-1.6	-1.8	-2.1
Bipolar Disorder (2011)	0.1	0.1	0.3	0.1	0.0	0.5	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.3	2.3	-0.6	-1.5	1.5	0.9	1.0
Coronary Artery Disease (CAD)	0.4	0.4	0.7	-0.9	-0.7	0.6	0.1	-0.8
Crohns Disease (2012)	0.6	0.9	2.5	0.5	0.7	-1.6	1.1	0.4
Mean Putamen Volume	0.7	0.8	2.5	0.1	-0.5	0.4	-1.1	1.6
Fasting Glucose	0.8	0.9	4.4	-0.2	0.3	-0.1	-2.1	0.2
HbA1C	0.3	0.3	0.7	-0.3	-0.5	0.3	-0.8	0.6
HDL Cholesterol	0.1	0.2	0.5	-0.3	-0.7	-0.3	0.1	0.4
LDL Cholesterol	0.7	1.1	3.4	-1.0	-0.8	0.5	0.4	1.8
Lupus	0.6	1.0	1.7	-0.9	0.3	0.8	1.3	1.3
Neuroticism (2016)	1.0	1.5	3.3	-1.0	0.7	1.8	1.6	-0.1
Primary Biliary Cirrhosis	1.6	2.2	7.0	0.2	1.7	-1.0	2.6	-0.4
Rheumatoid Arthritis	0.0	0.0	0.0	-0.2	0.2	-0.1	0.0	0.0
Schizophrenia (2014)	0.5	1.1	3.7	0.9	0.0	-0.4	1.9	-0.9
Triglycerides	0.3	0.4	1.1	-1.1	-0.3	0.4	0.8	0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.5	0.6	0.2	0.8	0.2
Ulcerative Colitis	0.4	0.6	1.4	0.0	0.6	-1.2	-0.9	-0.7
Blood Eosinophil Count	0.0	0.2	0.6	0.1	0.7	-0.5	0.7	0.0
Blood Platelet Count	0.2	2.5	6.5	2.5	-0.3	-1.9	-1.1	-1.0
Blood Red Count	0.1	0.6	1.9	-0.2	-1.4	-0.2	-0.5	0.8
Blood White Count	0.0	0.2	0.6	0.3	0.8	-0.1	0.4	-0.3
Heel T-Score	0.4	3.1	7.4	-2.7	-2.1	0.6	-1.1	1.6
BMI	1.1	6.2	10.6	3.3	3.1	0.2	0.6	-3.2
Height	0.0	0.6	1.2	0.1	0.7	1.1	-0.9	-0.7
Waist Hip Ratio (WHR)	6.4	28.6	99.6	0.6	-10.0	-1.5	-5.3	3.6
Systolic Blood Pressure	0.5	2.5	10.4	-0.2	-3.2	0.5	-1.0	0.8
Smoking Status	0.3	0.8	1.5	0.9	-0.5	-1.2	-1.0	0.4
Allergy or Eczema	0.7	1.8	3.6	1.5	0.8	-1.5	-0.6	-1.9
Cardiovascular Disease	0.9	3.1	7.2	2.7	-2.0	-1.4	0.3	-1.6
Hypothyroidism (self reported)	0.5	1.1	3.4	-0.6	-1.9	-0.1	-1.0	0.9
Respiratory disease	0.2	0.5	1.5	0.1	0.3	1.2	-0.3	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	0.4	-0.4	0.9	-0.6	0.4
Lung FEV1/FVC ratio	0.3	1.3	4.4	0.3	-1.1	-2.1	-0.9	-0.5
Lung FVC	0.2	0.9	2.8	-0.6	-1.1	-0.4	-1.7	-0.3
Neuroticism	0.6	1.4	2.9	-1.7	0.7	1.6	1.0	-0.2
Chronotype (morning person)	0.4	0.9	2.5	1.6	-0.6	-0.0	-1.2	0.2
Hair Pigment	0.0	1.4	4.0	-0.8	2.0	0.9	1.2	-0.2
Tanning	0.0	0.4	2.1	-0.2	0.2	0.2	-1.4	0.1
Hand grip strength (left)	0.8	2.0	7.4	-0.5	-2.7	0.5	-1.5	-0.2
Number of treatments/medications taken	0.3	0.5	1.9	1.4	-0.3	-0.5	0.2	-0.5
Average weekly spirits intake	0.8	1.0	2.2	-1.0	-1.5	0.3	-1.1	0.8
Sensitivity / hurt feelings	0.7	1.3	2.2	-1.5	1.3	1.2	0.6	0.6
Frequency of depressed mood in last 2 weeks	1.6	2.2	6.2	-2.0	-0.3	2.5	0.7	0.4
Hearing difficulty/problems: Yes	0.9	1.3	5.7	-0.7	2.4	-0.4	0.3	-0.1
Relative age of first facial hair	0.3	0.6	1.4	0.1	1.0	0.4	-0.5	-1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.5	0.8	1.2	-0.1	0.1	-0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.8	1.2	0.2	-0.6	1.3	0.3
Ever had hysterectomy (womb removed)	0.4	0.5	1.1	0.5	1.1	0.4	0.8	0.6
Systolic blood pressure, automated reading	0.3	0.9	2.1	-0.3	-0.8	1.5	-1.3	-0.1
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	4.1	1.4	-1.6	-2.0	-1.8	-1.3
Angina	0.5	0.6	2.4	1.6	-0.4	-0.6	0.1	0.3
Medication for hormone replacement therapy	0.4	0.5	1.9	0.0	-0.5	0.2	-1.4	0.5
Vitamin and mineral supplements	0.2	0.2	0.4	-0.3	-0.5	0.7	-0.5	0.1
Supplements: Zinc	0.8	0.9	2.2	0.6	0.9	-0.9	0.4	-1.5
Medication: Co-codamol	0.7	0.8	3.0	0.3	1.7	0.5	0.9	-0.2
Medication: Metformin	1.2	1.7	2.9	-0.5	-1.5	-0.9	-1.7	1.5
Diabetes (father)	1.0	1.3	4.4	0.7	-2.1	0.7	-0.2	1.0
Diabetes (mother)	0.7	0.9	2.3	-0.8	-1.5	1.0	0.4	0.8
Severe depression (siblings)	1.4	1.5	3.6	-1.4	-0.6	1.9	0.1	1.3
Pack years adult smoking proportion	2.1	3.2	5.4	2.0	2.3	-0.6	1.4	-2.1
Impedance of leg (right)	0.3	1.4	4.3	-0.5	0.6	-1.1	0.8	2.1
Leg fat-free mass (left)	0.2	1.1	3.5	0.8	-0.3	1.0	0.3	-1.9
Trunk fat percentage	1.4	5.5	14.0	1.1	3.7	-0.0	1.5	-3.1
Hand grip strength (right)	0.3	0.9	2.6	0.2	-1.6	-0.1	-1.3	-0.6
Townsend deprivation index at recruitment	0.4	0.5	2.2	0.3	1.5	-0.2	-0.4	0.1
Current tobacco smoking	1.1	1.7	5.3	1.5	1.1	-2.3	0.1	0.0
Average weekly fortified wine intake	0.6	0.8	1.4	-1.0	-0.9	1.2	0.5	-0.6
Maternal smoking around birth	0.7	1.0	3.2	0.4	0.4	-0.4	1.2	-1.8
Fed-up feelings	0.4	0.8	1.7	0.1	0.6	1.3	0.5	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.1	-0.5	-0.4	-0.8	-0.7
Relative age voice broke	0.5	0.7	1.6	0.7	1.2	0.3	-0.1	-1.3
Taking other prescription medications	0.2	0.2	0.5	-0.4	-0.4	0.7	0.4	0.5
Age when periods started (menarche)	0.3	0.7	1.6	-0.8	-0.6	-1.3	-0.0	1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	0.7	0.2	0.7	-0.1	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.1	-0.9	-1.3	-1.4	-0.7	1.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.7	0.1	0.5	-0.3	-0.3
Qualifications: CSEs or equivalent	0.2	0.3	1.0	-0.2	0.4	0.3	1.0	0.2
Serious illness, injury or assault to yourself	0.5	0.6	1.1	-1.0	1.0	0.3	0.9	0.2
High blood pressure	0.8	2.2	6.0	1.8	-2.4	-0.8	-0.0	-1.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	1.3	0.1	-0.7	-0.1	-0.9
Multivitamins +/- minerals	0.3	0.4	0.9	0.4	0.2	-0.5	0.9	-0.9
Stomach or abdominal pain in last month	0.5	0.6	1.8	0.4	1.3	0.4	0.8	-0.3
Supplements: Glucosamine	0.7	1.0	3.1	0.3	-0.7	-1.1	-1.8	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.4	0.2	0.1	1.2	-0.0	0.5
Medication: Atenolol	0.6	0.8	0.9	-0.6	-1.0	1.0	0.8	0.9
Medication: Levothyroxine sodium	0.6	1.0	2.6	-1.3	-1.6	-0.2	-0.1	0.9
Sitting height	0.2	1.6	3.2	-1.3	-1.8	1.3	-0.9	-0.8
Chronic bronchitis/emphysema (father)	0.9	1.0	3.5	0.8	1.9	-0.4	0.1	-0.8
High blood pressure (mother)	0.2	0.3	1.1	0.0	-0.2	-0.5	-0.5	-1.1
Body mass index (BMI)	0.9	3.7	7.9	2.2	2.1	0.1	1.0	-2.8
Impedance of leg (left)	0.2	1.0	2.0	-0.7	1.3	-0.6	0.6	1.4
Leg predicted mass (left)	0.2	1.1	3.4	0.9	-0.3	1.0	0.2	-1.9
Trunk fat mass	1.0	4.3	9.9	1.3	2.9	0.3	1.1	-3.1
Waist circumference	0.2	0.8	2.2	1.5	-1.0	-0.2	-0.4	-0.8
Number of incorrect matches in round	0.1	0.2	0.7	-0.2	0.0	-0.8	-0.1	-0.4
Past tobacco smoking	0.2	0.3	0.9	0.4	0.6	-0.2	1.0	0.0
Alcohol usually taken with meals	0.7	1.2	2.0	-1.3	0.5	1.3	0.4	-1.4
Nervous feelings	1.0	1.8	4.2	-2.1	0.6	1.5	1.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.6	-0.4	-0.2	0.6	-0.4
Hearing difficulty/problems with background noise	1.3	2.0	5.4	-0.9	2.3	1.1	1.6	0.3
Hair/balding pattern: Pattern 2	1.1	1.4	2.8	-1.0	-1.4	1.7	-1.1	0.3
Had menopause	0.3	0.4	1.1	0.8	0.3	0.5	1.1	-0.3
Had other major operations	1.8	2.1	2.8	1.5	0.4	-1.7	-1.6	-1.7
Forced vital capacity (FVC)	0.2	0.6	1.6	-0.9	-0.6	1.3	-0.3	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.1	-0.6	-1.1	-1.0	-0.6	1.0
Ever unenthusiastic/disinterested for a whole week	3.7	4.5	14.0	-0.2	1.7	2.4	3.7	0.4
Qualifications: None of the above	0.2	0.4	1.3	-0.0	-0.1	-0.6	0.4	1.1
Financial difficulties in last 2 years	0.4	0.6	1.9	0.1	-0.2	-0.8	-1.4	-0.4
Mouth/teeth dental problems	0.5	0.7	2.2	0.1	-0.8	-0.8	-0.4	-1.5
Heart attack	0.4	0.6	0.9	-0.9	0.9	0.8	0.6	-0.4
Allergy	0.1	0.2	0.6	-0.6	-0.8	0.5	-0.1	-0.3
Pain all over the body in last month	0.4	0.4	0.8	0.1	0.6	0.7	0.5	0.9
Diabetes (self-reported)	1.0	1.6	4.7	-0.5	-1.4	0.0	-1.0	2.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.3	1.1	-0.4	-0.7	-1.5	-1.4
Medication: Ramipril	0.4	0.5	1.5	0.2	-1.2	0.5	-0.7	0.3
Medication: Simvastatin	1.0	1.5	3.6	1.9	-0.3	-1.8	0.8	-0.1
Fluid intelligence score	0.7	1.4	3.7	-1.2	-0.2	1.9	-0.8	1.0
Illnesses of siblings	1.1	1.6	2.2	-1.5	-1.3	0.9	1.5	1.0
Neuroticism score	1.2	2.4	5.8	-1.3	1.5	2.4	1.6	-0.2
Weight	0.5	2.4	6.7	1.4	1.5	0.8	0.7	-2.6
Impedance of arm (right)	0.6	2.7	7.6	-2.8	1.7	0.4	1.3	1.2
Arm fat percentage (right)	1.1	4.2	8.7	1.4	3.0	-0.1	1.4	-2.9
Trunk fat-free mass	0.2	1.0	1.7	0.8	-1.3	1.1	-0.7	-0.9
Hip circumference	1.8	7.8	20.1	0.6	4.5	0.8	2.9	-3.1
Time employed in main current job	0.8	0.9	3.0	1.0	-0.5	1.7	0.1	-0.5
Alcohol intake versus 10 years previously	0.7	1.1	2.5	1.6	0.2	1.6	0.1	0.7
Father’s age at death	0.1	0.2	0.3	0.5	-0.2	-0.5	0.5	-0.1
Worrier / anxious feelings	0.4	0.7	1.5	0.1	1.2	0.9	0.7	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.6	1.3	0.4	0.8	0.2	-0.8
Falls in the last year	0.5	0.7	2.0	0.0	1.4	0.2	-0.4	1.1
Hair/balding pattern: Pattern 3	0.5	0.8	3.0	0.0	1.7	-0.4	0.7	-0.6
Number of live births	0.9	1.3	4.2	-0.4	-0.9	-0.4	-1.0	2.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.6	-1.5	-1.2	1.6	-0.1	0.2
Pulse rate	0.8	1.4	5.3	0.3	-0.7	-0.3	1.0	-2.3
Happiness	0.6	0.7	1.4	-1.0	0.9	0.5	1.2	-0.4
Noisy workplace	1.7	2.1	5.8	1.1	-0.3	-1.8	0.2	-2.4
Qualifications: A levels/AS levels or equivalent	1.1	2.4	5.9	1.1	0.2	-0.8	-2.0	-2.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.6	0.2	-0.3	-1.5	-1.6	-0.8
Mouth/teeth dental problems: Dentures	1.0	1.7	3.9	-2.0	0.1	0.7	0.4	1.9
Asthma	0.3	0.6	1.7	-0.6	-0.2	1.3	-0.5	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.9	1.2	-1.2	-1.4	-0.6	0.0
Medication: Cholesterol lowering	1.5	2.3	4.1	2.0	-0.0	-1.6	1.0	-2.0
Depression (self-reported)	1.2	1.5	3.3	-1.8	0.4	1.5	1.2	-0.3
Medication: Lansoprazole	0.6	0.6	1.2	1.1	0.8	-0.7	-0.4	-0.8
Prospective memory result	2.4	2.9	6.0	2.5	1.5	-1.0	0.3	-2.3
Lung cancer (father)	0.5	0.6	1.9	-1.4	-0.3	0.2	0.3	-0.9
Illnesses of mother	0.7	0.9	2.1	1.3	-0.4	0.4	0.6	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.2	-0.8	-0.4	0.6	1.1	-0.1
Pulse wave Arterial Stiffness index	2.9	3.3	9.0	2.2	0.5	-0.9	1.3	-3.0
Impedance of arm (left)	0.6	2.6	7.6	-2.8	1.4	0.4	1.0	1.5
Arm fat mass (right)	0.8	3.3	8.0	1.6	2.2	0.3	1.1	-2.8
Trunk predicted mass	0.2	0.9	1.4	0.8	-1.2	1.1	-0.6	-0.9
Standing height	0.1	1.3	2.6	-1.2	-1.6	1.4	-0.7	0.1
Length of working week for main job	1.6	1.8	4.6	0.6	-2.1	1.2	-1.4	0.6
Exposure to tobacco smoke at home	0.3	0.4	0.8	0.4	0.7	-0.9	0.0	-0.7
Breastfed as a baby	0.7	0.9	2.5	-0.7	-0.8	-0.5	-0.8	-1.6
Tense / ‘highly strung’	2.2	3.6	8.3	1.0	2.2	0.5	1.9	-2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.2	9.3	-1.0	3.0	2.2	2.4	-0.4
Hair/balding pattern: Pattern 4	0.5	1.3	3.2	1.7	-0.3	-1.8	-0.2	-0.5
Birth weight of first child	0.2	0.4	1.2	0.1	-0.7	1.1	0.5	-0.1
Peak expiratory flow (PEF)	1.7	3.9	6.2	-2.1	-2.3	2.5	-0.8	1.7
Pulse wave reflection index	1.7	2.1	4.8	0.9	2.2	-0.9	1.7	-1.2
Ever highly irritable/argumentative for 2 days	2.2	2.7	6.9	0.2	-0.9	2.6	1.6	1.8
Loud music exposure frequency	1.5	1.7	7.6	0.4	0.1	0.8	2.8	0.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.2	0.8	0.4	-2.0	-0.3	-1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.6	-0.5	-0.5	0.5	-0.8	0.5
Blood clot in the leg (DVT)	0.6	0.8	2.4	0.0	-1.0	-0.8	-0.5	1.5
Medication: Paracetamol	0.3	0.4	1.1	-0.7	-1.0	0.0	-0.7	0.5
Headache pain in last month	0.5	0.8	1.5	1.2	-0.2	-1.2	-0.7	0.8
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	5.4	-2.1	0.9	2.3	-0.1	1.9
Glaucoma (self-reported)	1.9	2.2	7.5	1.4	0.4	0.6	0.9	-2.7
Gout (self-reported)	1.7	2.4	4.4	0.2	-0.3	2.1	2.0	1.8
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.9	-0.0	-0.9	-0.3	-0.3	-0.0
Medication: Amlodipine	0.8	1.2	2.4	1.5	-0.8	-0.7	1.2	0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.0	-1.4	0.4	0.6	-0.2	0.4
Birth weight	1.0	2.2	4.1	-1.6	-2.0	1.3	-1.4	0.8
Chronic bronchitis/emphysema (mother)	1.8	2.0	3.7	1.4	1.9	-1.0	0.3	-1.9
High blood pressure (siblings)	0.7	1.0	2.8	1.7	0.5	-0.0	-1.2	-0.8
Forced vital capacity (FVC), Best measure	0.0	0.2	0.5	-0.5	-0.2	-0.0	0.7	-0.2
Body fat percentage	1.4	5.5	13.9	1.5	3.7	-0.2	1.6	-3.0
Leg fat percentage (right)	1.6	5.9	12.0	2.6	3.5	-0.8	1.8	-2.6
Arm fat-free mass (right)	0.2	1.2	2.8	1.4	-0.6	0.8	-0.4	-1.7
Exposure to tobacco smoke outside home	0.5	0.6	1.4	-0.3	-0.6	-0.7	-1.2	0.9
Comparative body size at age 10	0.7	1.9	8.4	0.4	1.0	-0.2	-0.0	-2.9
Number of full brothers	1.0	1.3	4.1	0.9	2.0	-1.2	0.1	0.3
Worry too long after embarrassment	0.6	1.1	2.7	-1.1	-0.2	1.6	0.2	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.3	-0.6	2.3	1.6	1.5	-0.4
Wheeze or whistling in the chest in last year	0.4	0.7	1.7	0.8	-0.4	-1.3	-0.9	0.1
Number of children fathered	0.3	0.3	0.7	-0.7	0.9	-0.7	0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.6	-1.3	0.0	0.9	-0.2	0.1
Age at first live birth	0.6	1.1	3.9	1.2	0.2	-0.1	-0.5	-2.0
Pulse wave peak to peak time	2.9	3.4	9.1	-2.2	-0.5	1.2	-1.3	3.0
Health satisfaction	0.9	1.2	2.7	0.7	-1.6	0.5	1.5	0.4
Shortness of breath walking on level ground	0.8	1.0	3.9	0.3	-0.8	-0.3	2.0	-0.5
Qualifications: College or University degree	0.4	1.1	3.1	0.0	0.9	1.8	0.8	-1.0
Eye problems/disorders: None of the above	0.9	1.1	5.0	0.1	-0.4	0.2	0.4	2.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.9	-0.3	2.0	0.2	-0.1	-0.8
Emphysema/chronic bronchitis	0.9	1.0	2.2	0.8	1.0	-1.5	-0.7	-0.7
Medication for pain relief, constipation, heartburn	1.2	2.1	4.4	-1.6	1.4	2.1	1.3	0.2
Neck or shoulder pain in last month	2.0	2.8	7.1	2.7	-1.3	-0.9	-2.1	-0.5
Medication: Blood pressure	0.6	1.0	1.8	1.1	-1.4	-1.2	0.0	-0.7
Angina (self-reported)	0.5	0.6	2.4	1.5	-0.4	-0.6	-0.0	0.3
Migraine (self-reported)	1.1	1.4	3.0	0.7	1.3	1.1	0.7	-1.7
Medication: Ibuprofen	0.5	0.6	1.1	1.0	-1.0	-0.9	0.2	0.1
Medication: Allopurinol	0.8	1.1	2.3	0.4	0.6	1.5	1.5	0.7
Medication: Omeprazole	1.0	1.2	3.4	1.8	0.5	-0.3	1.4	-0.7
Medication: Seretide 50 evohaler	0.7	0.8	1.9	-1.1	-0.2	1.4	0.8	0.4
Mean time to correctly identify matches	0.2	0.5	1.7	0.2	0.6	-0.0	1.3	-0.5
Heart disease (mother)	0.5	0.6	2.1	0.8	0.6	-0.1	0.0	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.9	-0.2	0.9	1.7	1.1	-0.3
Whole body fat mass	1.0	4.1	9.1	1.7	2.7	0.0	1.1	-3.0
Leg fat mass (right)	1.2	4.5	8.0	2.2	2.6	-0.1	1.6	-2.8
Arm predicted mass (right)	0.2	0.9	1.6	1.3	-0.6	1.0	-0.2	-1.2
Pulse rate, automated reading	0.5	1.7	5.5	1.5	-0.2	0.1	0.7	-2.3
Alcohol intake frequency.	0.4	0.9	3.3	1.8	0.0	0.7	0.2	0.8
Comparative height size at age 10	0.3	1.4	3.0	-1.7	-1.1	1.5	0.3	0.6
Number of full sisters	1.4	1.7	5.6	-2.4	0.5	-0.1	-1.5	-0.5
Suffer from ‘nerves’	1.2	1.9	2.8	-1.7	1.2	1.7	1.5	-0.0
Overall health rating	0.6	1.4	4.0	2.0	-0.4	-1.1	-0.6	-1.1
Chest pain or discomfort	0.5	0.7	2.4	0.7	0.2	-0.5	0.6	-1.6
Had major operations	1.0	1.2	4.8	-0.5	-0.1	0.7	2.2	0.5
Age at last live birth	0.7	1.0	2.7	1.7	0.6	-1.0	-0.6	-0.9
Family relationship satisfaction	0.8	1.0	2.8	1.7	0.7	-0.0	1.0	-0.7
Leg pain on walking	1.4	1.7	7.6	-0.0	1.0	0.3	2.8	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	-0.5	-0.5	0.5	-0.4	0.7
Commuting to job workplace: Car/motor vehicle	0.9	1.1	4.0	2.0	-0.1	-0.5	-0.0	-1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.5	0.8	-0.2	1.2	0.7	-0.0
Medication: Aspirin	0.2	0.3	0.5	0.6	-0.4	-0.7	-0.6	0.4
Supplements: Vitamin C	1.6	1.9	4.3	2.1	1.1	-0.6	1.6	-0.9
Knee pain experienced in last month	0.3	0.4	1.5	-1.2	0.6	0.4	0.5	0.1
Hypertension (Self-reported)	0.8	2.3	5.4	2.3	-2.0	-1.0	0.5	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	7.4	2.7	0.7	-1.5	0.4	-1.3
Illnesses of father: Heart disease	0.5	0.7	2.5	-0.7	0.8	-0.3	-0.2	-1.6
Illnesses of siblings: Diabetes	1.5	1.9	6.2	-0.6	-1.2	0.3	-2.5	1.2
Smoking status: Previous	0.1	0.2	0.6	-0.4	-0.2	0.1	-0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.7	-0.4	-0.8	-0.0	0.1	0.0
Whole body fat-free mass	0.2	1.0	2.0	0.9	-0.8	1.2	-0.4	-1.4
Leg fat-free mass (right)	0.2	1.3	4.4	0.7	-0.1	1.2	-0.1	-2.1
Arm fat percentage (left)	1.0	3.9	8.5	1.4	2.9	-0.2	1.1	-2.8
Average weekly red wine intake	0.2	0.2	0.9	0.0	-0.0	-0.5	-0.9	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.4	0.4	-1.2	-0.0	0.6	0.3
Mood swings	1.6	2.9	10.3	-1.3	0.1	3.2	1.4	0.8
Loneliness, isolation	2.7	3.7	10.3	-0.5	1.9	3.2	2.2	-0.1
Long-standing illness, disability or infirmity	0.2	0.3	1.1	-0.4	-0.4	0.3	-0.2	1.1
Ever had bowel cancer screening	0.1	0.1	0.5	-0.1	-0.1	0.7	-0.1	-0.1
Diabetes diagnosed by doctor	0.7	1.2	2.1	0.2	-1.4	-0.4	-1.4	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.3	0.6	1.5	-1.1	-0.7	-0.5
Friendships satisfaction	0.3	0.4	0.8	-0.1	-0.3	0.7	0.9	-0.8
Qualifications: nursing, teaching	0.4	0.6	2.4	0.6	-0.2	-0.2	-1.5	-0.2
Commuting to job workplace: Walk	0.3	0.3	1.0	-0.1	-0.2	0.7	0.1	1.0
Eye problems/disorders: Cataract	1.1	1.3	4.7	0.8	1.0	0.2	-0.1	-2.2
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	7.9	2.8	0.3	-0.2	-0.1	1.4
Medication for cholesterol	1.3	1.9	5.8	-1.8	2.4	-0.1	0.1	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.2	-0.5	-0.5	-0.4	-0.1	0.5
Back pain experienced in last month	1.3	1.9	3.3	1.6	1.3	-1.4	0.1	-1.8
Mineral and other dietary supplements	0.8	1.0	3.2	0.1	0.5	1.8	0.7	-1.1
Breast cancer (self-reported)	0.2	0.3	0.6	0.3	0.8	-0.7	0.5	0.2
Asthma (self-reported)	0.3	0.5	1.8	-0.4	-0.2	1.3	-0.4	0.7
Osteoporosis (self-reported)	0.3	0.4	1.4	1.2	-0.1	-0.3	0.5	0.6
Osteoarthritis (self-reported)	0.8	1.1	3.1	0.2	-1.3	1.8	-0.0	-0.6
Medication: Aspirin	0.3	0.4	0.7	0.5	-0.7	-0.6	-0.8	0.5
Medication: Gliclazide	0.6	0.7	1.9	-0.9	-1.4	-0.3	-0.1	0.7
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.5	-0.7	1.2	0.6	0.2
Smoking status: Current	0.7	1.1	2.7	1.3	0.6	-1.6	0.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.2	-1.2	-0.2	-0.9	0.5	1.5
Whole body water mass	0.2	1.0	1.9	0.8	-0.9	1.2	-0.3	-1.4
Leg predicted mass (right)	0.2	1.2	4.2	0.7	-0.0	1.2	-0.1	-2.0
Arm fat mass (left)	0.8	3.2	7.5	1.7	2.1	0.2	1.1	-2.7
Number of self-reported non-cancer illnesses	0.3	0.6	1.4	0.5	-1.2	0.4	0.2	-1.0
Average weekly champagne plus white wine intake	1.2	1.6	5.3	0.8	-0.3	0.6	-1.2	-2.3
Miserableness	1.1	1.9	4.9	-0.8	1.0	2.2	1.7	-0.5
Guilty feelings	0.2	0.3	0.7	0.1	0.7	0.3	0.4	0.8
Wears glasses or contact lenses	0.9	1.0	2.7	0.2	1.1	0.6	0.7	-1.7
Ever taken oral contraceptive pill	0.6	0.6	1.4	0.1	-1.2	0.8	0.8	0.8
Hearing aid user	1.4	1.6	3.3	0.7	0.9	-1.8	0.0	-1.8
Mother’s age at death	2.5	3.1	5.6	-2.4	-0.1	2.2	0.2	2.2
Financial situation satisfaction	1.2	1.5	6.1	0.9	-0.1	-2.5	-0.7	-0.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.6	0.8	0.4	-1.1	1.0	-1.3
Commuting to job workplace: Public transport	1.0	1.2	2.5	-1.5	-0.4	0.7	-0.6	1.6
Eye problems/disorders: Glaucoma	1.1	1.3	5.9	0.7	0.0	0.2	0.3	-2.4
Medication: Blood pressure	0.4	0.8	3.4	1.8	-0.5	0.3	0.7	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.6	0.3	-0.7	-0.2	1.3	0.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.1	-0.8	-0.8	-1.5	-0.2	1.2
High cholesterol (Self-reported)	0.9	1.6	2.4	1.5	-1.3	-0.8	1.5	-1.0
Medication: Bendroflumethiazide	0.4	0.6	1.1	1.0	-1.0	-0.9	-0.1	-0.5
Medication: Paracetamol	0.9	1.4	2.5	-0.9	-1.6	0.3	-1.6	0.9
Medication: Lisinopril	0.5	0.6	1.4	0.8	0.4	-1.2	0.2	1.0
Medication: Atorvastatin	0.3	0.4	1.2	1.1	0.1	-0.2	0.6	-0.6
Illnesses of father: High blood pressure	0.6	0.8	2.1	1.5	-0.6	-1.2	-0.0	0.1
Alcohol drinker status: Never	0.4	0.5	1.3	0.7	0.2	-0.5	-0.4	1.1
Ever smoked	0.2	0.3	0.6	-0.0	-0.8	0.2	-0.7	0.5
Basal metabolic rate	0.2	1.1	3.0	1.1	-0.3	1.1	0.0	-1.7
Leg fat percentage (left)	1.8	6.5	14.7	2.4	3.8	-0.5	1.7	-3.0
Arm fat-free mass (left)	0.2	1.1	2.4	1.4	-0.5	0.8	-0.4	-1.6
Number of operations (self-reported)	0.3	0.5	1.8	0.7	-0.1	-1.4	-0.0	0.2
Average weekly beer plus cider intake	0.9	1.3	4.2	1.5	-0.0	-2.0	0.2	0.3
Irritability	0.5	0.9	2.1	0.6	1.2	1.4	0.4	-0.6
Risk taking	0.3	0.4	0.9	0.4	0.8	0.4	-0.3	-0.9
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.4	1.5	0.6	-0.0	-1.1	-1.8
Fractured/broken bones in last 5 years	0.5	0.7	2.6	1.6	-0.2	0.0	-0.2	-0.8
Age started oral contraceptive pill	0.7	0.9	2.5	1.6	-0.9	-1.0	0.2	-0.4
Diastolic blood pressure, automated reading	0.3	0.9	1.9	-0.5	-1.1	1.4	-0.9	-0.6
Ever depressed for a whole week	3.4	4.2	10.7	0.2	1.9	2.6	3.3	-0.1
Unable to work because of sickness or disability	0.5	0.7	1.3	1.2	0.9	-1.1	0.2	-0.1
Commuting to job workplace: Cycle	0.5	0.6	1.6	0.8	0.3	0.7	-0.1	-1.3
Myopia	0.1	0.1	0.4	0.2	0.1	-0.2	0.6	0.2
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.8	-1.9	2.2	0.8	0.0	1.0
Cholesterol lowering medication	1.3	1.9	6.7	0.5	-1.1	0.8	0.8	2.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.6	1.9	1.2	-0.6	1.4	-1.4
Pain experienced in last month	0.4	0.7	2.6	-1.6	-0.4	0.7	0.2	0.6
Supplements: Calcium	0.9	1.0	2.3	1.5	0.6	-1.5	0.1	0.1
Basal cell carcinoma (self-reported)	1.3	1.5	3.5	-0.4	-1.9	1.3	0.4	1.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.2	-1.1	0.8	0.8	0.8	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	0.0	-0.8	-0.7	-0.5	1.3
Heart disease (siblings)	0.3	0.4	1.4	-0.1	1.2	0.1	-0.5	0.4
Alcohol drinker status: Previous	1.1	1.2	3.8	1.9	1.0	0.7	0.1	-0.9
Pack years of smoking	2.3	3.4	5.6	2.0	2.4	-0.7	1.4	-2.2
Impedance of whole body	0.4	2.0	3.5	-1.9	1.7	-0.2	1.0	1.6
Leg fat mass (left)	1.3	4.9	9.5	2.1	2.9	0.2	1.7	-3.1
Arm predicted mass (left)	0.2	1.1	2.7	1.5	-0.3	0.6	0.1	-1.6