Hub : Genes

ENPP6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1040	0.0310	3.6e-04	0.069	0.020	0.023	0.030	0.049	7.7e-09	1.6e-03	7.3e-04	0.00012	1.3e-06
2	METSIM	Adipose	0.0499	0.0202	4.7e-03	0.043	0.003	0.020	0.012	0.045	4.7e-07	9.6e-02	4.3e-04	0.00480	2.2e-07
3	NTR	Blood	0.0340	0.0120	1.0e-03	-0.001	0.012	0.000	0.011	-0.001	6.0e-01	7.6e-05	2.9e-01	0.00012	5.6e-01
4	TCGA	Breast Invasive Carcinoma	0.0715	0.0184	1.7e-12	0.069	0.063	0.069	NA	0.070	6.6e-14	6.5e-13	5.8e-14	NA	3.5e-14
5	TCGA	Lung Adenocarcinoma	0.0618	0.0252	8.9e-04	-0.002	0.035	0.008	NA	0.003	6.9e-01	4.8e-05	3.8e-02	NA	1.3e-01
6	TCGA	Prostate Adenocarcinoma	0.0425	0.0216	4.8e-03	0.004	0.010	0.008	NA	0.009	1.3e-01	3.1e-02	4.4e-02	NA	3.8e-02
7	TCGA	Thyroid Carcinoma	0.1430	0.0490	4.0e-06	0.078	0.066	0.071	NA	0.068	5.1e-08	5.0e-07	2.1e-07	NA	3.4e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.4	1.5	0.4	0.2	1.2	0.4	0.2	-0.8	-0.3
Bipolar Disorder or Schizophrenia	0.6	1.5	3.3	0.1	1.3	1.8	1.1	1.5	-1.1	0.7
Depressed Affect (Nagel 2018)	0.1	0.3	0.8	0.2	-0.8	-0.1	-0.1	-0.4	0.1	-0.9
Depression (Nagel 2018)	0.4	0.5	2.5	-0.1	-0.4	-1.0	-0.0	0.3	-0.1	-1.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.2	-0.9	-0.5	1.3	-1.8	-1.3	-0.2	-0.7
Neuroticism (Nagel 2018)	0.7	1.5	3.7	0.6	-1.5	-0.7	-0.4	-1.9	0.5	-1.9
Schizophrenia (2018)	0.8	1.7	3.4	-0.2	1.9	1.4	1.0	1.9	-0.7	1.2
Schizophrenia vs Biploar Disorder	0.5	0.7	2.6	-1.6	0.8	-0.7	0.5	-0.2	-0.7	0.7
Worry (Nagel 2018)	0.9	1.9	6.2	-0.2	-1.8	-0.3	-1.0	-2.5	0.4	-1.6
Alzheimer’s Disease (in mother)	1.6	1.9	5.4	-0.8	-1.1	-1.2	-1.1	-1.5	1.0	-2.3
Alzheimer’s Disease (in father)	0.5	0.6	1.5	-1.2	0.1	0.7	-0.7	-1.2	0.1	-0.4
Alzheimer’s Disease (including proxy)	0.8	1.2	3.3	-1.2	-0.3	-0.6	-0.7	-1.7	0.1	-1.8
Crohns Disease (2017)	0.4	0.8	3.2	1.8	0.1	-0.2	-0.2	-0.1	-0.1	-1.5
Irritable Bowel Disease (IBD)	0.3	0.7	2.3	1.3	-0.2	-0.4	0.3	-0.1	-0.8	-1.5
Ulcerative Colitis (UC)	0.3	0.5	1.2	0.1	-0.6	-0.3	1.0	-0.5	-0.9	-1.1
Major Depression (MDD)	0.3	0.4	1.3	0.5	0.2	-0.4	1.0	-0.4	-1.2	-0.1
Reaction Time	1.1	2.2	5.7	-1.7	0.2	-2.2	1.2	-2.4	-0.7	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.4	-0.4	-0.5	0.6	-1.6	-0.4	0.2	-0.5
Breast Cancer	0.4	0.9	2.8	-1.1	-0.2	-1.2	-0.2	-0.5	1.7	-0.5
Ovarian Cancer	0.9	1.2	2.8	0.3	-1.6	1.1	-0.8	-0.5	0.8	-1.7
Prostate Cancer	0.7	1.0	1.9	-1.2	0.8	-1.4	-1.0	0.6	-0.6	1.2
Age at First Birth	1.1	1.6	7.8	-1.1	-0.5	-2.8	-0.4	-1.1	0.9	0.1
Bipolar Disorder (2011)	0.5	0.5	1.6	0.7	-0.4	0.1	-0.5	0.8	0.1	-1.3
Body Mass Index (BMI) (2010)	0.4	0.5	2.2	-0.5	-0.0	0.2	-1.5	0.0	0.7	0.8
Coronary Artery Disease (CAD)	0.3	0.3	1.1	0.3	0.1	-0.8	-0.1	0.1	0.5	-1.1
Crohns Disease (2012)	0.6	0.9	1.7	1.2	0.8	1.2	0.3	1.3	-0.2	-1.1
Mean Putamen Volume	0.2	0.2	1.3	0.0	-0.1	-1.1	0.2	0.1	0.1	-0.2
Fasting Glucose	1.7	2.1	4.9	-0.2	1.3	2.2	1.5	1.2	-0.9	1.9
HbA1C	0.2	0.3	0.8	0.7	0.3	-0.0	0.6	0.9	-0.1	0.3
HDL Cholesterol	0.1	0.2	0.8	-0.5	0.2	0.1	0.6	0.1	-0.9	-0.2
LDL Cholesterol	0.2	0.3	0.9	-0.3	-0.0	-0.7	-0.0	-1.0	0.4	0.5
Lupus	1.4	2.1	5.8	-0.4	1.3	0.4	2.0	0.7	-2.4	1.5
Neuroticism (2016)	0.5	0.8	2.3	-0.1	1.5	-1.2	0.3	0.5	-0.8	0.8
Primary Biliary Cirrhosis	0.7	1.0	3.9	1.1	-0.2	-2.0	0.1	-1.3	-0.4	-0.3
Rheumatoid Arthritis	1.1	1.5	3.0	-0.9	1.3	-1.3	1.7	0.7	-1.6	0.3
Schizophrenia (2014)	0.5	1.0	1.8	-0.8	1.4	1.2	0.9	0.7	-1.3	0.7
Triglycerides	0.4	0.7	2.2	0.3	-0.3	-0.7	-0.5	-1.5	1.0	0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.3	-0.9	-0.0	-0.4	0.2	-1.1	-0.8	-0.1
Ulcerative Colitis	0.6	0.9	3.8	-0.1	0.2	0.3	2.0	-0.3	-1.4	-0.0
Blood Eosinophil Count	0.1	0.8	2.6	0.2	1.2	-0.5	0.8	1.6	0.1	0.7
Blood Platelet Count	0.1	1.1	1.9	0.8	-1.4	-1.2	-0.9	-0.5	0.8	-1.4
Blood Red Count	0.2	2.3	4.9	-1.8	0.1	-1.4	-2.2	-1.4	1.7	-1.1
Blood White Count	0.3	2.3	4.9	-0.7	1.9	-2.2	-1.0	1.3	0.2	2.1
Heel T-Score	1.4	11.5	26.5	-2.2	-3.4	-2.4	-4.5	-2.8	5.2	-1.8
BMI	0.3	1.7	4.1	-1.1	1.5	0.7	-0.1	2.0	0.2	2.0
Height	0.2	3.0	8.1	2.8	1.3	-2.2	2.2	0.1	-1.0	-1.0
Waist Hip Ratio (WHR)	0.2	0.9	3.8	-0.3	1.9	0.0	-0.2	0.2	-1.3	0.6
Systolic Blood Pressure	0.1	0.4	1.6	0.7	0.5	-0.0	0.2	1.3	0.4	0.4
Smoking Status	1.0	2.5	5.9	1.8	2.1	-0.7	1.3	2.4	-1.0	0.6
Allergy or Eczema	0.9	2.4	5.3	-1.0	1.6	0.1	1.7	-0.5	-2.1	2.3
Cardiovascular Disease	0.5	1.6	4.8	0.8	2.2	0.5	1.0	1.0	-1.1	1.6
Hypothyroidism (self reported)	0.2	0.5	1.1	0.4	-1.0	-0.7	0.1	0.8	0.9	0.2
Respiratory disease	1.4	3.2	8.7	1.6	2.9	-2.3	1.1	0.4	-1.5	1.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	0.2	-0.4	0.8	0.4	-0.2	-0.7	0.4
Lung FEV1/FVC ratio	0.3	1.3	5.7	-1.5	-0.6	2.4	-0.3	-0.9	0.1	-0.2
Lung FVC	0.1	0.4	1.0	-0.5	-0.7	0.4	0.7	-1.0	0.4	0.2
Neuroticism	0.4	1.1	2.6	1.0	-1.3	-1.1	-0.1	-1.6	0.3	-1.0
Chronotype (morning person)	0.1	0.3	0.9	-0.6	-0.2	-0.6	0.9	0.2	-0.0	-0.4
Hair Pigment	0.0	0.6	2.7	0.1	-0.2	0.3	1.0	1.6	0.3	0.5
Tanning	0.4	4.6	12.4	0.6	2.6	-0.4	3.5	1.4	-3.0	1.3
Hand grip strength (left)	0.3	0.8	4.1	0.2	-0.1	-0.4	0.4	0.7	0.7	2.0
Number of treatments/medications taken	1.7	3.1	5.9	-0.2	2.4	-1.4	1.9	0.8	-1.9	2.4
Average weekly spirits intake	2.1	2.7	4.1	-0.9	2.0	-1.7	2.0	1.2	-1.6	1.7
Sensitivity / hurt feelings	0.7	1.1	2.6	1.6	-1.2	0.2	1.6	-1.1	-0.0	-0.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	0.5	0.4	-0.3	0.4	0.4	-0.6	-0.6
Hearing difficulty/problems: Yes	1.7	2.6	7.0	-0.7	0.4	-2.3	1.4	-1.8	-2.7	-0.4
Relative age of first facial hair	0.5	1.0	2.8	0.6	-1.7	-0.9	0.8	-1.2	-0.9	-0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.9	0.9	-0.4	0.1	0.2	-0.1	-0.7	-0.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.6	0.6	1.6	-1.3	0.9	0.2	-1.4	0.9
Ever had hysterectomy (womb removed)	1.1	1.3	4.6	0.2	-1.3	1.3	-0.7	-0.5	-0.2	-2.1
Systolic blood pressure, automated reading	0.1	0.2	0.4	0.5	0.6	-0.2	0.2	0.6	-0.1	-0.4
Eye problems/disorders: Diabetes related eye disease	1.8	1.9	4.9	1.0	-0.7	-1.7	-1.8	0.8	2.2	-0.4
Angina	0.3	0.4	1.1	0.4	0.8	0.1	0.1	1.1	-0.3	1.0
Medication for hormone replacement therapy	0.5	0.5	1.8	0.1	0.9	0.4	-0.2	1.4	0.2	0.9
Vitamin and mineral supplements	0.6	0.8	2.3	0.8	-0.4	0.2	-1.3	-0.5	0.4	-1.5
Supplements: Zinc	0.8	0.8	4.0	0.1	-0.6	-1.1	0.3	0.4	-0.1	2.0
Medication: Co-codamol	0.8	0.9	4.5	-0.9	0.2	0.7	0.1	-0.3	-0.6	-2.1
Medication: Metformin	0.4	0.6	2.3	-0.2	-0.5	-0.4	-0.1	-1.5	0.7	-0.8
Diabetes (father)	1.9	2.3	4.3	1.6	-1.4	2.1	-1.6	-0.4	2.0	-1.0
Diabetes (mother)	1.3	1.6	2.8	-1.6	1.7	-0.5	1.2	1.6	-0.7	1.2
Severe depression (siblings)	1.5	1.6	4.0	2.0	1.0	1.4	1.4	1.1	-0.7	0.8
Pack years adult smoking proportion	0.5	0.8	1.9	1.4	1.2	0.6	0.8	0.5	-0.3	1.0
Impedance of leg (right)	0.3	1.3	3.8	-0.1	1.9	-0.7	0.7	-0.4	-1.4	1.6
Leg fat-free mass (left)	0.2	0.9	3.1	0.1	0.7	-0.1	1.4	1.8	0.1	0.9
Trunk fat percentage	0.5	2.1	5.1	-0.3	1.7	0.4	1.3	2.3	-0.4	2.0
Hand grip strength (right)	0.4	1.1	3.7	1.6	-0.6	0.4	0.1	0.1	0.9	1.9
Townsend deprivation index at recruitment	1.2	1.7	4.7	1.7	2.2	0.4	0.8	1.2	-0.4	1.2
Current tobacco smoking	1.0	1.6	6.3	0.8	1.8	-0.6	0.6	2.5	0.1	0.6
Average weekly fortified wine intake	1.3	1.5	2.9	0.3	-0.7	1.7	0.8	-1.6	-1.2	-1.6
Maternal smoking around birth	1.5	2.2	10.0	1.1	0.5	0.8	-1.2	3.2	0.8	1.2
Fed-up feelings	0.2	0.4	1.0	0.3	0.1	-1.0	-0.6	-0.6	0.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	3.3	0.1	-0.6	-1.8	0.1	0.1	0.6	-1.7
Relative age voice broke	0.2	0.3	0.7	0.5	-0.8	-0.9	-0.5	-0.1	-0.3	0.3
Taking other prescription medications	1.4	2.2	6.2	-0.4	2.5	-1.4	0.1	1.0	-0.8	2.3
Age when periods started (menarche)	0.1	0.2	0.4	0.4	-0.4	-0.2	-0.6	0.4	-0.3	0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	0.4	0.4	-0.6	1.2	0.9	-0.0	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.2	11.7	-2.7	-2.1	-1.5	-3.0	-2.8	3.4	-1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	0.1	-1.0	-0.6	0.6	0.0	-0.0	-0.5
Qualifications: CSEs or equivalent	1.4	1.8	8.4	0.2	0.3	2.9	0.6	1.5	0.1	1.2
Serious illness, injury or assault to yourself	0.5	0.6	2.0	0.7	-0.5	0.6	0.6	0.8	-1.4	-0.2
High blood pressure	0.3	0.7	1.5	1.0	1.2	0.1	-0.2	1.2	0.4	0.9
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.5	-0.7	2.3	-0.6	2.4	0.8	-2.0	2.5
Multivitamins +/- minerals	0.5	0.6	1.4	-0.8	-0.3	-0.2	1.0	1.1	-0.0	1.2
Stomach or abdominal pain in last month	0.1	0.2	0.4	-0.4	0.1	0.4	0.4	0.3	-0.6	0.3
Supplements: Glucosamine	0.3	0.4	1.7	1.3	-0.8	-0.5	0.3	-0.0	0.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	2.7	0.7	0.4	1.1	0.1	1.7	0.8	-0.2
Medication: Atenolol	0.1	0.2	0.6	-0.2	0.7	0.1	0.1	-0.8	0.0	-0.3
Medication: Levothyroxine sodium	0.4	0.6	2.1	-0.7	-0.4	-1.5	-0.2	0.8	0.9	0.1
Sitting height	0.2	1.2	5.4	0.0	0.2	-2.3	1.2	0.3	-1.0	0.5
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	0.1	0.5	-0.4	-0.4	0.5	0.2	-0.5
High blood pressure (mother)	0.2	0.2	1.0	0.1	0.6	0.4	0.1	-0.4	1.0	-0.1
Body mass index (BMI)	0.2	0.9	2.6	0.0	1.0	-0.2	0.9	1.6	0.2	1.4
Impedance of leg (left)	0.2	0.9	2.2	-0.1	1.5	-0.7	0.6	-0.2	-1.1	1.4
Leg predicted mass (left)	0.1	0.8	2.9	0.1	0.6	-0.2	1.3	1.7	0.1	0.8
Trunk fat mass	0.5	2.2	4.8	-0.2	1.8	-0.1	1.6	2.2	-0.5	2.1
Waist circumference	0.2	0.8	1.6	0.9	1.3	-1.2	0.6	1.1	-0.1	0.5
Number of incorrect matches in round	1.4	2.4	4.8	0.4	2.1	-0.3	1.7	2.2	-0.9	2.0
Past tobacco smoking	1.1	2.0	6.8	-2.6	-0.5	0.5	-1.7	-0.4	1.8	0.7
Alcohol usually taken with meals	1.2	1.9	5.6	-1.4	-1.7	-1.1	-1.2	-2.4	-0.3	-0.6
Nervous feelings	0.5	1.0	3.0	-1.4	-0.4	-1.3	-0.0	-1.7	0.2	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	4.2	-1.0	-0.7	-1.9	-1.1	-2.0	-0.4	-1.6
Hearing difficulty/problems with background noise	1.9	3.0	12.0	0.5	0.5	-1.1	2.5	-0.6	-3.5	0.9
Hair/balding pattern: Pattern 2	1.7	2.2	6.8	2.6	-1.9	-0.4	1.2	-0.7	-1.3	-1.0
Had menopause	0.2	0.3	1.1	0.3	0.3	0.1	-0.0	-0.2	1.1	-0.8
Had other major operations	1.0	1.2	2.8	-0.3	1.3	0.2	1.7	0.7	-1.2	1.4
Forced vital capacity (FVC)	0.2	0.6	2.3	0.7	0.2	-0.3	1.5	0.1	-0.4	1.2
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.9	12.1	-2.5	-2.3	-1.7	-3.1	-3.5	3.1	-1.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.1	0.1	0.5	-0.2	0.6	1.1	0.3	0.4
Qualifications: None of the above	1.0	2.2	4.7	0.9	2.2	-1.9	0.6	1.7	0.4	1.5
Financial difficulties in last 2 years	0.3	0.4	0.8	0.8	0.6	-0.9	0.8	0.2	-0.7	0.0
Mouth/teeth dental problems	1.2	1.8	6.2	-2.5	-0.7	1.4	-1.6	-0.8	0.8	0.6
Heart attack	0.3	0.3	0.8	0.8	0.9	0.0	-0.2	0.5	0.7	0.5
Allergy	1.2	2.7	7.4	-0.2	-2.6	0.9	-1.4	-0.9	1.1	-2.7
Pain all over the body in last month	0.3	0.4	0.9	0.0	0.7	-0.6	-0.6	0.3	0.9	0.6
Diabetes (self-reported)	0.4	0.5	2.0	0.4	-0.8	0.4	0.2	-1.4	-0.3	-0.9
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	3.9	0.2	1.6	-1.5	1.7	0.9	-2.0	1.8
Medication: Ramipril	1.1	1.3	4.0	-0.2	0.7	0.2	1.3	2.0	-0.5	1.7
Medication: Simvastatin	0.9	1.3	3.1	1.1	1.8	-0.2	0.9	0.6	-1.3	1.4
Fluid intelligence score	0.2	0.3	1.2	-0.7	0.3	0.1	-1.1	-0.5	0.6	-0.2
Illnesses of siblings	0.4	0.6	1.6	-0.3	-1.2	-0.0	0.5	-1.3	-0.7	-0.6
Neuroticism score	0.2	0.5	1.0	0.3	-0.8	-0.8	-0.2	-1.0	0.6	-0.7
Weight	0.3	1.5	2.9	0.8	1.3	-0.9	1.7	1.5	-0.4	1.3
Impedance of arm (right)	0.2	1.1	3.5	0.7	0.9	0.1	0.7	1.9	-0.4	1.5
Arm fat percentage (right)	0.5	2.1	6.0	-0.4	1.3	-0.1	1.3	2.5	-0.3	2.2
Trunk fat-free mass	0.2	1.0	2.8	0.8	0.4	-1.6	1.7	0.4	-0.6	0.2
Hip circumference	0.3	1.3	4.3	1.2	0.4	-2.1	1.0	1.1	0.4	0.6
Time employed in main current job	0.3	0.3	0.7	-0.8	0.0	-0.4	-0.4	0.8	0.6	0.7
Alcohol intake versus 10 years previously	0.2	0.4	1.2	0.1	0.8	1.1	0.8	0.2	-0.3	-0.1
Father’s age at death	0.7	0.9	2.7	0.9	0.6	0.7	0.1	-1.3	-0.6	-1.7
Worrier / anxious feelings	1.2	2.2	4.8	-0.4	-1.0	-2.2	-0.8	-2.2	1.0	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.0	-0.7	-0.3	-0.4	-0.7	1.0	-0.0	-0.5
Falls in the last year	1.0	1.4	3.3	1.0	-1.4	1.3	-0.1	1.3	-0.1	-1.8
Hair/balding pattern: Pattern 3	0.9	1.3	5.4	-2.3	0.8	-0.7	0.5	0.0	-0.6	1.5
Number of live births	0.6	0.9	3.1	-0.6	-0.0	-0.1	-1.0	-1.0	-0.9	-1.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.8	0.6	-0.2	0.7	1.4	-0.4	-0.2	0.9
Pulse rate	0.8	1.3	4.7	0.2	0.3	2.2	1.4	0.2	-1.4	-0.6
Happiness	2.8	3.4	8.0	0.3	-2.2	-1.5	-1.4	-2.8	0.6	-2.5
Noisy workplace	1.1	1.3	3.3	-1.4	0.8	-0.5	1.1	1.8	-0.2	1.3
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.9	-1.4	-0.5	-0.4	-0.7	-1.3	0.7	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.0	3.6	0.7	1.9	1.5	1.8	0.5	-1.3	1.6
Mouth/teeth dental problems: Dentures	0.5	0.9	4.2	2.1	0.3	-1.0	-0.2	0.6	0.4	-0.5
Asthma	1.7	3.3	8.2	1.3	2.9	-2.1	0.7	1.5	-0.4	2.4
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.6	0.7	-0.8	-1.1	-2.1	0.2	2.0	-1.2
Medication: Cholesterol lowering	1.1	1.7	6.8	0.0	2.6	0.5	0.4	0.8	-0.2	2.0
Depression (self-reported)	0.8	0.9	2.2	0.1	0.9	0.5	1.5	0.4	-1.3	1.1
Medication: Lansoprazole	0.3	0.3	1.2	0.2	0.4	0.1	-1.1	-0.4	0.5	0.4
Prospective memory result	1.8	2.2	5.4	1.3	0.7	0.5	2.3	2.3	0.1	1.4
Lung cancer (father)	0.4	0.4	1.3	0.2	-0.5	-1.1	0.7	-0.3	0.9	-0.3
Illnesses of mother	0.5	0.6	1.8	-0.2	-0.1	0.2	-0.9	0.9	-1.0	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	0.2	-0.2	0.8	0.8	-0.4	0.1	0.3
Pulse wave Arterial Stiffness index	0.6	0.7	3.9	0.1	0.1	-1.1	0.1	-0.2	0.3	-2.0
Impedance of arm (left)	0.1	0.4	0.7	0.8	0.6	0.6	0.3	0.8	-0.4	0.7
Arm fat mass (right)	0.4	1.6	3.7	-0.2	1.1	-0.5	1.5	1.9	-0.2	1.9
Trunk predicted mass	0.2	1.0	3.0	0.8	0.5	-1.6	1.7	0.4	-0.7	0.2
Standing height	0.2	2.0	5.8	1.3	1.1	-1.8	2.4	0.1	-1.6	0.5
Length of working week for main job	0.6	0.6	2.0	1.4	-0.1	-0.9	-0.3	0.8	0.6	-0.5
Exposure to tobacco smoke at home	0.3	0.3	0.9	0.9	0.4	0.6	0.3	0.4	-0.5	-0.7
Breastfed as a baby	1.5	1.9	7.5	-1.6	-1.2	2.7	0.9	0.6	-0.4	-0.3
Tense / ‘highly strung’	0.6	1.0	4.4	0.0	-1.0	-1.1	-0.7	-2.1	0.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.1	0.4	0.0	-0.7	1.4	0.2	0.2	0.2
Hair/balding pattern: Pattern 4	0.5	1.3	3.4	0.8	0.0	-0.8	-0.6	-1.8	-0.7	-1.8
Birth weight of first child	0.7	1.3	5.2	-2.3	0.5	-0.7	-0.8	-0.9	-0.2	-1.3
Peak expiratory flow (PEF)	0.7	1.7	4.5	0.7	-2.1	-0.1	-1.4	-1.3	1.6	-0.8
Pulse wave reflection index	0.6	0.7	3.0	-0.2	0.2	-1.0	-0.6	-0.5	0.4	-1.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.4	-0.4	1.2	-0.4	0.5	-0.2	-0.7	0.1
Loud music exposure frequency	0.6	0.6	2.7	-0.2	-0.4	1.6	-0.9	-0.6	0.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.7	-1.7	-0.5	0.6	-0.4	-0.2	1.1	-0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.1	1.5	0.4	-0.2	1.3	1.2	-0.2	-0.2
Blood clot in the leg (DVT)	1.0	1.2	6.2	0.2	-0.7	0.0	-1.2	0.7	2.5	-0.2
Medication: Paracetamol	0.4	0.6	1.6	-0.0	-0.4	-1.3	-0.2	-0.9	0.1	-1.3
Headache pain in last month	0.5	0.9	2.4	-0.3	-1.1	-1.0	-1.6	-1.2	0.4	-0.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.9	0.1	-2.4	-0.3	0.3	-1.5	-0.2	-2.0
Glaucoma (self-reported)	0.2	0.3	1.7	0.3	0.4	-1.3	-0.3	0.3	0.0	0.0
Gout (self-reported)	0.4	0.5	1.2	-0.7	0.7	1.1	0.5	0.3	1.0	0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.2	-0.4	-0.3	-1.8	-0.1	1.1	0.9	0.5
Medication: Amlodipine	0.1	0.1	0.6	-0.1	-0.3	0.5	0.3	-0.0	0.2	0.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.2	0.4	0.9	-0.7	0.9	0.6	-0.8	1.8
Birth weight	0.7	1.6	7.8	0.6	-0.1	-2.8	0.2	-0.5	1.2	-1.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.8	-0.7	-0.1	0.2	-0.3	0.7	-0.2
High blood pressure (siblings)	0.2	0.2	0.6	-0.1	0.6	0.2	-0.4	0.8	0.5	0.6
Forced vital capacity (FVC), Best measure	0.1	0.2	0.9	0.3	0.3	0.1	0.9	0.1	0.1	0.6
Body fat percentage	0.6	2.4	5.6	-0.4	2.0	0.1	1.4	2.1	-0.7	2.4
Leg fat percentage (right)	0.9	3.3	7.9	-0.8	2.8	-0.2	1.6	1.9	-1.4	2.6
Arm fat-free mass (right)	0.1	0.4	1.0	0.8	0.6	-0.6	1.0	0.4	0.1	-0.1
Exposure to tobacco smoke outside home	0.8	1.0	2.6	1.4	-0.5	1.6	-0.9	-0.4	0.6	-1.1
Comparative body size at age 10	0.5	1.5	5.8	1.6	0.9	-2.4	1.0	0.4	0.1	0.2
Number of full brothers	1.5	2.0	7.4	0.4	0.8	-0.9	2.7	1.1	-1.8	0.2
Worry too long after embarrassment	2.7	4.5	10.5	0.8	-3.2	-1.2	-1.8	-2.1	2.1	-2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	4.3	-0.8	-0.4	0.1	2.1	-1.0	-1.1	0.2
Wheeze or whistling in the chest in last year	1.3	2.4	6.0	-0.5	2.4	-2.4	1.2	1.4	0.0	1.3
Number of children fathered	0.7	0.8	1.6	-1.2	-0.5	0.5	1.0	-0.9	-1.0	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.4	1.6	-0.0	-0.7	-0.0	-0.5	-0.3	-0.5
Age at first live birth	0.9	1.6	4.9	-1.0	-1.6	-0.3	-1.0	-0.3	1.3	-2.2
Pulse wave peak to peak time	0.5	0.6	3.5	0.1	-0.1	0.6	-0.0	0.0	-0.3	1.9
Health satisfaction	1.0	1.3	2.8	1.6	-0.4	-1.7	-0.7	-1.1	0.2	-1.3
Shortness of breath walking on level ground	0.4	0.5	1.7	0.3	0.9	-1.3	0.4	0.6	0.1	0.4
Qualifications: College or University degree	1.0	3.2	7.4	-1.1	-2.2	-0.3	-1.2	-2.6	0.8	-2.7
Eye problems/disorders: None of the above	1.9	2.2	4.8	-1.9	-1.7	0.5	-1.5	-2.2	0.1	-1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	-1.2	-0.6	0.3	1.1	0.9	0.0	0.5
Emphysema/chronic bronchitis	1.4	1.6	3.1	0.9	1.3	-1.1	-1.0	1.7	-0.8	1.8
Medication for pain relief, constipation, heartburn	0.6	1.1	2.9	-0.5	-1.3	1.7	-1.0	-0.7	0.4	-1.0
Neck or shoulder pain in last month	1.0	1.4	3.7	1.1	1.9	-1.8	0.7	0.9	-0.5	-0.2
Medication: Blood pressure	0.4	0.7	1.5	-0.0	1.2	0.6	-0.6	1.0	0.6	1.2
Angina (self-reported)	0.3	0.4	1.6	0.4	0.7	0.2	0.0	0.8	-0.2	1.3
Migraine (self-reported)	1.1	1.4	4.8	0.5	0.9	-0.6	1.1	0.4	-2.2	1.5
Medication: Ibuprofen	1.3	1.5	2.6	1.2	-1.1	-1.5	-1.3	-0.3	1.6	-1.2
Medication: Allopurinol	0.4	0.5	1.3	-1.1	0.5	0.9	0.5	0.2	0.5	0.7
Medication: Omeprazole	0.4	0.5	1.3	-0.5	0.9	-0.7	1.1	0.4	-0.6	0.1
Medication: Seretide 50 evohaler	2.7	3.1	8.1	-0.2	2.8	-0.9	1.2	2.2	-1.6	1.9
Mean time to correctly identify matches	1.4	2.6	6.0	-2.1	0.2	-2.4	1.1	-2.5	-0.9	-0.2
Heart disease (mother)	0.5	0.6	2.1	0.4	-0.0	-0.9	0.6	-0.5	-0.5	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	7.1	-0.4	-2.7	0.3	-1.8	-2.2	1.2	-2.2
Whole body fat mass	0.5	2.3	5.1	-0.1	1.8	-0.3	1.6	2.1	-0.6	2.3
Leg fat mass (right)	0.8	3.2	7.0	-0.5	2.6	-0.4	1.8	2.1	-0.9	2.6
Arm predicted mass (right)	0.0	0.2	0.5	0.5	0.4	-0.6	0.7	0.1	0.1	-0.0
Pulse rate, automated reading	0.6	2.0	3.8	0.1	2.0	1.5	1.5	1.8	-1.5	0.5
Alcohol intake frequency.	0.3	0.6	1.4	-1.1	1.0	-0.7	0.1	0.0	-0.1	1.2
Comparative height size at age 10	0.7	4.0	8.6	0.4	2.8	-1.9	2.9	1.1	-2.0	1.7
Number of full sisters	0.5	0.6	2.3	1.1	0.3	1.5	0.3	0.8	0.4	-0.1
Suffer from ‘nerves’	2.8	4.4	14.5	-1.1	-2.2	-0.9	-1.9	-3.8	0.8	-2.2
Overall health rating	0.4	0.8	2.4	1.6	0.9	-0.7	-1.0	0.0	0.1	-0.8
Chest pain or discomfort	0.4	0.6	1.5	0.7	0.4	-1.1	-1.2	-0.6	0.4	-0.7
Had major operations	0.5	0.5	2.4	0.5	0.2	-0.7	1.5	0.2	-0.8	-0.1
Age at last live birth	2.0	2.9	6.2	-1.5	-2.3	1.2	-1.7	-0.8	1.2	-2.5
Family relationship satisfaction	3.2	3.9	10.4	1.0	-2.3	-1.0	-1.4	-2.7	0.7	-3.2
Leg pain on walking	0.3	0.4	1.0	0.3	0.7	-0.1	0.7	1.0	-0.0	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.0	1.6	-0.5	1.7	0.8	0.7	0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.3	-1.8	0.2	0.1	1.0	1.0	-0.2	-0.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	4.9	-0.3	-1.4	-2.2	-0.9	-0.7	1.1	-0.5
Medication: Aspirin	0.3	0.3	1.7	1.3	-0.5	-0.1	0.2	-0.1	0.3	0.5
Supplements: Vitamin C	0.4	0.5	1.5	-0.4	0.8	-0.9	0.7	0.3	0.1	1.2
Knee pain experienced in last month	0.8	1.3	5.0	2.2	1.1	1.0	0.8	0.6	-1.0	-0.0
Hypertension (Self-reported)	0.3	0.7	2.2	1.0	1.5	-0.1	0.4	1.1	-0.1	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.7	-1.9	0.2	1.9	-1.6	-1.9	-0.3	-1.0
Illnesses of father: Heart disease	0.5	0.7	1.3	-1.1	-1.1	-0.1	-0.2	0.9	1.2	-0.1
Illnesses of siblings: Diabetes	0.7	0.9	3.4	0.4	1.3	-1.8	-0.0	-0.2	-0.8	-0.1
Smoking status: Previous	1.4	2.1	8.8	3.0	0.6	-0.9	1.6	-0.2	-1.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	0.3	-0.4	0.4	0.6	0.4	-0.3	0.5
Whole body fat-free mass	0.1	0.7	2.2	0.5	0.5	-1.1	1.5	0.9	-0.2	0.4
Leg fat-free mass (right)	0.1	0.6	2.7	0.2	0.1	-0.2	1.1	1.6	0.4	0.4
Arm fat percentage (left)	0.4	1.8	4.5	-0.4	1.5	0.3	0.9	2.1	-0.2	2.1
Average weekly red wine intake	0.4	0.5	2.4	0.0	-0.3	-0.2	1.1	-1.5	-0.2	-0.2
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.9	-1.1	1.5	-0.3	-0.6	1.8	1.4	2.0
Mood swings	0.5	0.9	3.7	-0.6	0.7	-1.9	1.0	-0.4	-0.4	-0.5
Loneliness, isolation	0.8	1.1	4.1	0.4	0.2	1.8	0.2	2.0	0.3	0.5
Long-standing illness, disability or infirmity	2.1	3.2	8.0	1.4	2.5	-1.5	1.8	1.1	-2.8	0.1
Ever had bowel cancer screening	2.5	2.9	9.0	0.3	1.9	-0.0	2.1	0.4	-3.0	1.8
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.0	-0.4	0.4	0.8	-0.8	-0.7	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.6	0.1	-0.2	-0.2	-0.8	-0.4	-0.3
Friendships satisfaction	1.0	1.3	3.2	0.7	-1.5	-0.5	0.4	-1.4	-0.8	-1.8
Qualifications: nursing, teaching	0.5	0.7	1.3	-1.1	-0.8	1.1	-0.6	0.2	-0.6	-1.0
Commuting to job workplace: Walk	1.3	1.4	4.4	0.2	-0.4	-0.4	-2.1	-1.5	1.4	-0.9
Eye problems/disorders: Cataract	2.3	2.7	5.4	0.8	2.2	-1.1	1.4	2.3	-0.3	2.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.2	0.2	0.7	0.1	1.5	-0.0	-1.0	1.0
Medication for cholesterol	1.1	1.6	3.7	-0.9	-1.2	0.6	-1.8	-0.7	1.9	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	-0.7	0.6	0.3	-0.1	0.3	0.2	0.9
Back pain experienced in last month	0.8	1.2	5.6	1.3	0.6	-2.4	-0.3	0.2	0.0	-0.7
Mineral and other dietary supplements	0.7	1.0	3.4	-1.0	0.4	0.3	-1.1	-0.3	0.9	-1.8
Breast cancer (self-reported)	0.9	1.1	2.2	1.3	0.1	-0.1	1.3	-1.5	-1.0	-1.1
Asthma (self-reported)	2.1	4.2	10.7	1.4	3.3	-2.1	1.1	1.9	-0.8	2.7
Osteoporosis (self-reported)	1.5	1.8	4.1	0.9	1.3	1.7	1.5	0.9	-2.0	0.3
Osteoarthritis (self-reported)	0.9	1.2	3.0	1.7	0.3	1.1	1.2	0.7	-0.5	-1.3
Medication: Aspirin	0.4	0.5	1.9	1.4	-0.3	-0.3	0.9	0.4	0.1	0.8
Medication: Gliclazide	0.7	0.8	2.4	0.1	1.6	-0.6	1.1	0.8	-0.4	1.0
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	-0.6	1.0	-0.4	-0.6	-0.6	-0.2	1.0
Smoking status: Current	1.0	1.6	5.9	0.5	1.9	-0.5	0.5	2.4	-0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.9	-2.0	0.1	1.1	-0.0	-0.5	0.5	0.8
Whole body water mass	0.1	0.6	1.6	0.4	0.4	-1.0	1.2	0.9	0.0	0.5
Leg predicted mass (right)	0.1	0.6	2.8	0.2	0.0	-0.2	1.1	1.7	0.4	0.4
Arm fat mass (left)	0.3	1.4	3.2	0.0	1.2	-0.3	1.4	1.8	-0.2	1.8
Number of self-reported non-cancer illnesses	0.9	1.6	3.9	0.7	2.0	-1.9	1.0	0.2	-1.0	1.2
Average weekly champagne plus white wine intake	2.4	3.3	9.6	-1.2	-1.8	1.6	-3.1	-1.4	1.5	-1.6
Miserableness	0.3	0.6	2.0	0.7	-1.0	0.5	-0.2	-0.6	0.4	-1.4
Guilty feelings	0.2	0.3	0.6	-0.5	-0.7	-0.6	-0.0	-0.7	0.8	0.4
Wears glasses or contact lenses	1.1	1.2	4.3	-0.3	0.3	-1.3	-1.1	-2.1	-1.1	0.3
Ever taken oral contraceptive pill	0.6	0.7	2.2	-0.9	0.2	-1.5	-0.9	0.6	-0.7	0.5
Hearing aid user	2.3	2.6	8.3	0.2	0.2	-1.4	2.9	0.6	-2.4	1.3
Mother’s age at death	1.3	1.6	5.0	-0.7	-1.5	-0.7	-0.6	-2.2	1.1	-1.3
Financial situation satisfaction	1.0	1.2	2.6	0.3	-1.1	-1.3	-1.6	-1.2	0.8	-0.9
Tinnitus: Yes, now most or all of the time	0.9	1.1	4.9	0.4	-1.2	-0.8	0.5	-2.2	-0.1	0.1
Commuting to job workplace: Public transport	0.6	0.7	1.8	1.1	0.5	-0.8	0.2	-0.3	-1.1	1.3
Eye problems/disorders: Glaucoma	0.3	0.3	0.9	0.6	0.6	-1.0	-0.2	0.6	-0.1	0.3
Medication: Blood pressure	0.4	0.7	2.2	0.8	0.5	-0.9	1.0	-0.3	-1.5	-0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.8	1.3	-0.4	1.0	-0.3	0.2	-0.5	-0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.4	0.3	-1.6	0.1	0.7	0.2	0.0	0.9
High cholesterol (Self-reported)	0.9	1.6	2.7	0.7	1.6	1.5	1.6	0.6	-0.9	1.4
Medication: Bendroflumethiazide	0.8	1.2	2.3	0.8	1.5	-0.6	1.1	0.6	-1.3	1.5
Medication: Paracetamol	0.9	1.5	3.3	0.3	-1.0	-1.8	0.3	-1.6	0.2	-1.8
Medication: Lisinopril	0.5	0.7	1.3	1.0	0.9	-0.2	0.6	0.5	-1.2	1.0
Medication: Atorvastatin	0.3	0.4	1.3	-1.1	0.7	-0.3	0.4	0.1	-0.5	-0.6
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.4	-0.5	0.1	-0.1	0.2	0.1	-0.1
Alcohol drinker status: Never	0.8	1.0	3.1	-1.8	-0.3	-0.5	1.6	0.2	-1.0	0.4
Ever smoked	0.6	1.0	2.1	1.1	-0.1	0.3	1.4	-0.2	-1.4	-1.3
Basal metabolic rate	0.2	0.9	2.4	0.6	0.6	-1.0	1.5	1.2	-0.2	0.7
Leg fat percentage (left)	0.8	2.8	5.9	-0.7	2.4	0.0	1.6	2.0	-1.2	2.4
Arm fat-free mass (left)	0.1	0.6	2.5	0.5	0.2	-0.9	1.6	0.5	-0.1	0.2
Number of operations (self-reported)	2.9	4.4	7.7	0.5	2.8	-0.8	2.8	1.6	-2.6	2.2
Average weekly beer plus cider intake	0.6	0.9	1.8	0.5	1.1	1.1	1.0	1.4	-0.3	0.6
Irritability	1.5	2.5	6.8	0.1	1.6	-2.2	2.6	-0.1	-1.8	-0.1
Risk taking	1.0	1.4	4.0	0.7	0.2	-0.2	1.5	0.4	-1.8	2.0
Ever had prostate specific antigen (PSA) test	1.2	1.4	5.4	-2.3	-0.8	-0.5	-1.1	-1.5	0.0	0.1
Fractured/broken bones in last 5 years	1.3	1.7	4.8	2.2	0.1	1.5	1.5	0.4	-1.3	-0.9
Age started oral contraceptive pill	0.1	0.2	0.9	-0.0	0.3	-0.9	-0.0	-0.4	0.3	0.0
Diastolic blood pressure, automated reading	0.1	0.4	0.9	0.3	0.3	0.8	0.2	0.9	0.7	-0.7
Ever depressed for a whole week	0.3	0.3	0.9	0.7	-0.5	-0.4	0.9	0.0	0.4	-0.5
Unable to work because of sickness or disability	0.5	0.7	1.9	0.2	0.1	0.1	1.4	1.2	-1.2	0.2
Commuting to job workplace: Cycle	1.0	1.2	3.1	1.1	-0.8	0.4	-1.2	-1.3	0.6	-1.7
Myopia	0.8	1.2	2.3	0.7	0.9	-0.3	1.3	-1.1	-1.5	-1.2
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.5	-1.2	-1.2	-0.1	0.2	-1.1	-0.4	-1.1
Cholesterol lowering medication	1.4	2.1	7.0	0.0	0.7	-0.3	2.4	-0.6	-2.6	1.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.9	-0.9	0.6	-0.7	0.0	-0.0	-0.1	-0.5
Pain experienced in last month	0.5	0.9	3.3	-1.0	-1.8	1.0	-0.1	-0.6	0.8	0.1
Supplements: Calcium	1.4	1.5	4.5	0.8	1.0	0.6	0.9	1.0	-2.1	1.6
Basal cell carcinoma (self-reported)	0.8	0.9	2.7	-1.1	1.6	0.4	-0.1	0.9	0.5	1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.7	1.2	0.1	0.1	0.8	0.7	0.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	6.2	0.0	-0.1	-0.1	-1.1	0.8	2.5	0.1
Heart disease (siblings)	1.2	1.5	4.4	0.7	1.2	0.3	0.6	1.0	-1.7	2.1
Alcohol drinker status: Previous	0.7	0.8	4.3	0.5	-0.2	-2.1	-0.5	-0.7	0.3	-0.2
Pack years of smoking	0.6	0.8	2.5	1.3	1.6	0.1	0.6	0.3	-0.4	1.0
Impedance of whole body	0.1	0.3	0.8	0.4	0.9	0.3	0.2	0.2	-0.6	0.8
Leg fat mass (left)	0.8	3.0	6.5	-0.4	2.4	-0.2	1.8	2.2	-0.8	2.5
Arm predicted mass (left)	0.1	0.5	1.6	0.5	0.4	-0.9	1.3	0.6	0.1	0.1