TWAS hub - EOMES

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0258	0.0102	4.0e-03	0.024	0.005	0.022	0.015	0.024	1.8e-08	1.0e-02	6.6e-08	8.6e-06	3.0e-08
2	YFS	Blood	0.0436	0.0135	1.3e-05	0.020	0.013	0.024	0.017	0.023	2.5e-07	2.8e-05	1.4e-08	2.2e-06	3.8e-08
3	TCGA	Prostate Adenocarcinoma	0.1127	0.0401	1.1e-09	0.103	0.100	0.100	NA	0.095	6.3e-11	1.3e-10	1.3e-10	NA	4.0e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Number of full brothers	7.5	9.4	14.7	-2.4	-3.8	-2.8
Blood White Count	6.2	46.1	74.8	8.7	4.7	6.5
Blood Eosinophil Count	5.8	44.7	80.0	8.9	0.8	7.3
Stomach or abdominal pain in last month	5.4	6.7	10.2	3.2	0.4	3.1
Rheumatoid Arthritis	5.2	7.1	17.2	4.2	-1.0	1.8
Long-standing illness, disability or infirmity	5.1	7.8	15.8	4.0	1.1	2.5
Bipolar Disorder (2011)	4.8	4.6	10.2	-3.2	-1.5	-1.1
Qualifications: O levels/GCSEs or equivalent	4.6	7.3	11.8	-3.4	-1.5	-2.8
Shortness of breath walking on level ground	4.1	4.9	7.2	2.6	2.7	0.9
Schizophrenia vs Biploar Disorder	3.8	5.0	7.7	2.8	0.4	2.7
Overall health rating	3.6	7.7	11.6	3.4	2.6	2.2
Average weekly spirits intake	3.5	4.3	5.2	1.9	2.3	2.0
Heart attack/myocardial infarction (self-reported)	3.5	4.6	4.9	2.2	2.2	2.0
Loud music exposure frequency	3.4	3.7	6.1	2.0	2.5	1.0
Blood Platelet Count	3.2	37.5	74.1	8.6	0.2	6.2
Heart attack	3.2	4.0	5.0	2.2	1.8	1.9
Frequency of tiredness / lethargy in last 2 weeks	3.2	5.2	8.0	2.8	1.4	2.4
Other serious medical condition/disability diagnosed by doctor	2.9	3.7	6.9	2.6	1.1	1.7
Qualifications: A levels/AS levels or equivalent	2.9	6.3	10.8	-3.3	0.6	-2.8
Medication: Blood pressure	2.9	5.2	5.7	2.4	2.4	2.0
Schizophrenia (2018)	2.7	5.6	9.4	2.4	1.3	3.1
Qualifications: None of the above	2.5	5.3	11.0	3.3	0.1	2.2
Father’s age at death	2.5	3.4	5.5	-2.1	-0.8	-2.3
Diabetes (father)	2.4	2.9	4.4	-2.0	-0.4	-2.1
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	6.1	-2.5	-1.7	-1.5
Wheeze or whistling in the chest in last year	2.3	4.1	4.8	2.2	1.7	2.1
Qualifications: nursing, teaching	2.3	3.5	6.2	-2.5	-0.5	-2.0
Number of self-reported non-cancer illnesses	2.3	4.0	9.6	3.1	0.7	1.4
Waist circumference	2.2	8.2	12.8	3.6	2.2	2.7
Hayfever/allergic rhinitis (self-reported)	2.1	2.7	3.8	-1.6	-1.9	-1.3
Ever highly irritable/argumentative for 2 days	2.1	2.5	5.0	2.2	0.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	4.9	1.2	2.2	1.1
Supplements: Vitamin C	2.1	2.5	3.5	1.8	1.0	1.9
Number of operations (self-reported)	2.1	3.1	7.6	1.2	-0.2	2.8
Qualifications: CSEs or equivalent	2.0	2.6	4.1	2.0	1.0	1.7
Alcohol intake versus 10 years previously	2.0	3.0	6.1	2.5	1.5	0.8
Hearing difficulty/problems with background noise	1.9	3.1	4.6	2.1	0.7	2.1
Fluid intelligence score	1.9	4.0	7.9	-2.8	-0.7	-1.9
Prospective memory result	1.9	2.3	4.0	1.3	2.0	1.1
Smoking status: Previous	1.9	2.9	4.3	2.1	0.2	2.1
Back pain experienced in last month	1.9	2.8	6.2	2.5	0.1	1.5
Vascular/heart problems diagnosed by doctor	1.9	5.1	8.1	-2.9	-2.1	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.7	5.3	1.6	0.5	2.3
Leg pain on walking	1.8	2.3	4.6	2.1	1.5	0.3
Ever taken oral contraceptive pill	1.8	2.0	3.5	1.9	0.2	1.6
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.2	1.4	0.9	1.8
Nervous feelings	1.7	3.1	6.5	1.7	-0.2	2.6
Medication: Ramipril	1.7	2.2	3.9	1.3	2.0	1.1
Osteoarthritis (self-reported)	1.7	2.2	3.7	1.9	0.5	1.6
Alcohol drinker status: Never	1.7	2.1	4.0	-0.1	-2.0	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.4	1.8	-0.1	1.7
Bipolar Disorder (2018)	1.6	2.5	3.9	-2.0	-0.9	-1.7
Depressed Affect (Nagel 2018)	1.6	3.4	5.8	1.5	2.4	1.4
Hearing difficulty/problems: Yes	1.6	2.4	3.1	1.8	1.1	1.7
Number of live births	1.6	2.2	3.7	-1.4	-1.0	-1.9
Medication: Cholesterol lowering	1.6	2.5	5.6	2.4	0.8	1.1
Exposure to tobacco smoke at home	1.6	1.8	3.0	1.7	-0.1	1.6
Pulse rate, automated reading	1.6	5.3	6.8	2.2	2.0	2.6
Number of full sisters	1.6	1.9	4.4	2.1	1.0	0.5
Commuting to job workplace: Cycle	1.6	1.9	3.0	-0.6	-1.7	-1.5
Verbal and Numeric Reasoning (VNR)	1.5	3.5	5.3	-2.3	-0.0	-2.3
Fed-up feelings	1.5	2.7	4.5	2.1	1.4	1.2
Past tobacco smoking	1.5	2.8	5.0	-2.2	-0.5	-1.8
Diabetes (self-reported)	1.5	2.3	4.6	1.1	2.1	1.1
Blood clot in the leg (DVT)	1.5	2.0	5.5	-0.6	-0.1	-2.3
Medication: Paracetamol	1.5	2.5	4.5	1.4	1.0	2.1
Coronary Artery Disease (CAD)	1.4	1.7	3.7	0.3	1.1	1.9
Leg fat percentage (right)	1.4	5.2	6.6	2.5	2.6	1.7
Medication for pain relief, constipation, heartburn	1.4	2.3	2.9	-1.7	-1.2	-1.6
Angina (self-reported)	1.4	1.8	4.5	2.1	-0.5	0.9
Leg fat mass (right)	1.4	5.4	8.2	2.9	2.1	1.9
Leg fat percentage (left)	1.4	5.1	6.7	2.6	2.4	1.7
Ever depressed for a whole week	1.4	1.7	2.7	-0.1	1.5	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	5.1	-0.5	-0.4	-2.3
Leg fat mass (left)	1.4	5.5	8.5	2.9	1.9	2.0
Fasting Glucose	1.3	1.6	3.6	-0.8	-0.7	-1.9
Schizophrenia (2014)	1.3	2.9	6.2	1.1	1.1	2.5
Happiness	1.3	1.5	2.9	0.9	1.0	1.7
High blood pressure (siblings)	1.3	1.9	3.0	1.6	1.7	-0.2
Loneliness, isolation	1.3	1.8	4.9	0.1	2.2	0.6
Diabetes diagnosed by doctor	1.3	2.1	3.2	1.3	1.8	1.2
Pain experienced in last month	1.3	2.2	3.1	-1.6	-0.9	-1.8
Neuroticism (Nagel 2018)	1.2	2.8	3.7	1.7	1.3	1.9
Ovarian Cancer	1.2	1.6	4.0	2.0	0.9	0.1
Lung FVC	1.2	5.9	10.1	-2.7	-0.8	-3.2
Chronotype (morning person)	1.2	2.9	4.4	1.4	-1.5	2.1
Angina	1.2	1.5	4.1	2.0	-0.4	0.6
Medication: Co-codamol	1.2	1.4	3.8	0.2	0.7	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	2.9	0.9	1.0	1.7
Age when periods started (menarche)	1.2	2.8	4.0	-2.0	-1.5	-1.4
Medication: Simvastatin	1.2	1.8	4.8	2.2	0.7	-0.4
Hip circumference	1.2	5.3	7.3	2.7	2.2	2.0
Birth weight of first child	1.2	2.2	6.0	0.4	2.4	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.5	-1.6	-0.3	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.2	1.4	0.1	1.5
Age at last live birth	1.2	1.7	2.2	-1.4	-1.0	-1.5
Knee pain experienced in last month	1.2	1.9	3.1	1.3	1.8	0.9
Arm fat mass (left)	1.2	4.8	6.6	2.6	2.1	1.9
Hayfever, allergic rhinitis or eczema	1.1	2.3	5.8	-2.4	-0.1	-1.1
Pulse rate	1.1	1.8	2.3	1.4	1.5	1.1
Hair/balding pattern: Pattern 4	1.1	2.5	3.4	-1.9	-1.1	-1.8
Health satisfaction	1.1	1.5	2.2	1.5	1.5	-0.2
Unable to work because of sickness or disability	1.1	1.5	2.6	1.3	-0.1	1.6
Smoking Status	1.0	2.5	4.1	2.0	0.5	1.7
Average weekly fortified wine intake	1.0	1.2	2.1	-0.5	-1.1	-1.5
High blood pressure	1.0	2.9	4.1	2.0	1.8	1.1
Body mass index (BMI)	1.0	4.4	6.8	2.6	1.6	2.0
Had menopause	1.0	1.2	1.8	-1.0	0.9	-1.4
Weight	1.0	4.9	6.7	2.6	1.9	2.1
Noisy workplace	1.0	1.2	2.0	-0.2	1.3	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.6	-0.9	-1.6	0.1
Lung cancer (father)	1.0	1.2	1.5	1.2	1.0	1.0
Arm fat mass (right)	1.0	4.0	5.3	2.3	1.9	1.7
Heart disease (mother)	1.0	1.2	2.1	1.2	-0.1	1.5
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.8	-0.6	1.7	-0.7
Arm fat-free mass (left)	1.0	5.2	7.9	2.8	1.1	2.6
Supplements: Calcium	1.0	1.1	1.7	1.3	1.1	0.6
Depression (Nagel 2018)	0.9	1.4	2.5	0.7	1.1	1.6
Intelligence (Savage-Jansen 2018)	0.9	2.8	5.4	-2.3	-0.5	-1.7
Respiratory disease	0.9	1.9	3.0	1.6	-0.3	1.7
Medication for hormone replacement therapy	0.9	1.0	2.0	-0.9	-1.4	-0.5
Medication: Metformin	0.9	1.2	2.5	0.9	0.6	1.6
Severe depression (siblings)	0.9	1.1	1.7	-1.3	0.7	-1.0
Serious illness, injury or assault to yourself	0.9	1.1	1.8	1.3	0.1	1.2
Trunk fat mass	0.9	3.8	5.0	2.2	2.0	1.5
Breastfed as a baby	0.9	1.1	2.0	-1.1	-0.0	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.3	-0.3	1.8	0.1
Whole body fat mass	0.9	3.9	5.3	2.3	2.0	1.5
Chest pain or discomfort	0.9	1.3	2.4	1.6	0.7	1.0
Had major operations	0.9	1.1	2.5	0.7	-0.3	1.6
Hypertension (Self-reported)	0.9	2.6	3.8	1.7	2.0	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.7	1.3	-0.3	-1.2
Friendships satisfaction	0.9	1.1	3.2	0.1	1.8	0.2
Guilty feelings	0.9	1.3	2.8	-1.1	-0.2	-1.7
Arm predicted mass (left)	0.9	4.6	6.6	2.6	1.2	2.4
Allergy or Eczema	0.8	2.0	4.8	-2.2	-0.7	-0.8
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.0	0.3	1.1	1.4
Systolic blood pressure, automated reading	0.8	2.2	2.8	1.7	1.5	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	4.8	0.5	-0.5	2.2
Alcohol usually taken with meals	0.8	1.3	1.8	-1.3	0.6	-1.3
Had other major operations	0.8	1.0	2.0	0.8	0.7	1.4
Glaucoma (self-reported)	0.8	1.0	1.9	1.0	1.4	0.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.0	-1.4	-0.8	-0.5
Qualifications: College or University degree	0.8	2.4	5.0	-2.2	-0.5	-1.4
Emphysema/chronic bronchitis	0.8	0.9	1.4	0.9	0.6	1.2
Medication: Ibuprofen	0.8	0.9	2.4	-1.6	0.5	0.1
Medication: Omeprazole	0.8	0.9	1.1	0.9	-1.0	1.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.8	-0.3	0.9	1.3
Medication: Aspirin	0.8	1.1	1.6	1.2	1.2	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.8	-1.3	1.3	0.3
Osteoporosis (self-reported)	0.8	1.0	1.8	1.3	-0.6	0.9
Average weekly champagne plus white wine intake	0.8	1.1	2.0	-1.4	-1.1	0.3
Financial situation satisfaction	0.8	1.0	2.9	0.1	1.7	0.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.5	1.6	0.4	0.6
Medication: Atorvastatin	0.8	1.0	2.4	0.7	0.4	1.5
Irritability	0.8	1.3	1.9	1.3	1.4	0.6
Mean Putamen Volume	0.7	0.8	1.7	0.1	1.3	-0.9
BMI	0.7	4.0	5.9	2.4	1.3	2.1
Hypothyroidism (self reported)	0.7	1.6	2.8	-1.3	-0.3	-1.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	0.8	-0.9	0.9	-0.7
Mouth/teeth dental problems	0.7	1.1	2.8	0.6	-1.7	0.3
Impedance of arm (right)	0.7	3.2	4.8	-2.2	0.2	-2.2
Time employed in main current job	0.7	0.8	1.0	0.6	-1.0	1.0
Trunk predicted mass	0.7	3.7	4.7	2.2	1.5	2.1
Body fat percentage	0.7	2.9	3.8	2.0	1.8	1.2
Arm fat-free mass (right)	0.7	3.5	5.3	2.3	0.9	2.0
Number of children fathered	0.7	0.8	1.7	-0.6	-1.3	0.6
Neck or shoulder pain in last month	0.7	1.0	1.7	1.3	0.2	1.1
Suffer from ‘nerves’	0.7	1.1	2.3	0.7	1.5	0.7
Illnesses of siblings: Diabetes	0.7	0.8	2.0	-0.7	-1.4	0.1
Arm fat percentage (left)	0.7	3.0	3.9	2.0	1.9	1.2
Mood swings	0.7	1.3	2.4	1.2	0.2	1.6
Commuting to job workplace: Public transport	0.7	0.8	1.1	-1.0	1.0	-0.6
Basal metabolic rate	0.7	3.7	5.5	2.4	1.1	2.1
Age started oral contraceptive pill	0.7	0.9	1.5	-1.2	-0.7	-0.9
Alzheimer’s Disease (in father)	0.6	0.6	1.6	-1.3	0.4	0.2
Crohns Disease (2017)	0.6	1.3	2.5	-1.2	0.1	-1.6
Age at First Birth	0.6	0.8	2.2	-0.2	-0.5	-1.5
Body Mass Index (BMI) (2010)	0.6	0.9	1.8	-0.9	0.3	-1.3
Ulcerative Colitis	0.6	0.8	1.5	0.3	-1.0	1.2
Vitamin and mineral supplements	0.6	0.8	1.5	-1.2	-0.6	-0.6
Maternal smoking around birth	0.6	0.9	1.1	1.0	-1.1	0.7
Arm fat percentage (right)	0.6	2.4	3.2	1.8	1.7	1.0
Trunk fat-free mass	0.6	3.6	4.4	2.1	1.5	2.0
Falls in the last year	0.6	0.9	1.8	0.6	0.7	1.3
Impedance of arm (left)	0.6	3.0	4.5	-2.1	0.2	-2.1
Exposure to tobacco smoke outside home	0.6	0.7	1.5	1.2	0.2	0.8
Arm predicted mass (right)	0.6	3.0	4.8	2.2	0.7	1.9
Commuting to job workplace: Walk	0.6	0.7	1.8	1.3	-0.4	0.1
Illnesses of father: None of the above (group 1)	0.6	0.8	1.4	1.2	-0.5	0.9
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	1.3	0.7	-0.3
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	0.5	1.1	0.8
High cholesterol (Self-reported)	0.6	1.1	2.7	1.6	-0.5	-0.4
Illnesses of father: High blood pressure	0.6	0.7	1.8	0.5	1.3	0.2
Risk taking	0.6	0.8	1.9	-1.4	-0.5	-0.6
Myopia	0.6	0.9	1.4	1.1	1.2	0.4
Worry (Nagel 2018)	0.5	1.1	2.4	0.9	-0.0	1.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	-1.2	0.5	0.6
HDL Cholesterol	0.5	0.9	1.1	1.1	-0.9	0.8
Systolic Blood Pressure	0.5	2.5	2.8	1.5	1.6	1.7
Hair Pigment	0.5	14.2	24.7	5.0	3.1	2.8
Ever had hysterectomy (womb removed)	0.5	0.5	1.2	-1.1	-0.6	-0.1
Trunk fat percentage	0.5	2.0	2.8	1.7	1.6	0.9
Taking other prescription medications	0.5	0.8	2.0	1.4	0.5	0.3
Neuroticism score	0.5	1.1	1.5	0.9	1.2	1.0
Medication: Lansoprazole	0.5	0.5	1.6	1.2	0.0	-0.1
Whole body fat-free mass	0.5	3.0	4.5	2.1	1.0	1.9
Average weekly red wine intake	0.5	0.8	1.2	-1.0	-0.5	-1.1
Ever had bowel cancer screening	0.5	0.6	1.2	-1.1	-0.6	-0.5
Medication for cholesterol	0.5	0.8	1.9	0.7	0.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.2	-0.7	0.4	-1.5
Whole body water mass	0.5	3.1	4.5	2.1	0.9	2.0
Mother’s age at death	0.5	0.6	1.3	-1.1	0.2	-0.7
Ever smoked	0.5	0.9	1.2	1.1	0.8	0.9
Cholesterol lowering medication	0.5	0.8	2.3	-0.2	0.0	-1.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	0.7	-1.1	0.5
Heart disease (siblings)	0.5	0.7	1.9	-0.1	0.2	-1.4
Reaction Time	0.4	0.7	1.7	1.3	0.4	0.5
Crohns Disease (2012)	0.4	0.6	1.0	1.0	0.4	0.7
LDL Cholesterol	0.4	0.6	1.1	0.0	-1.1	-0.8
Lupus	0.4	0.6	1.1	0.7	1.1	0.5
Neuroticism	0.4	0.9	1.3	0.6	1.0	1.1
Number of treatments/medications taken	0.4	0.7	1.9	1.4	0.5	0.2
Sensitivity / hurt feelings	0.4	0.7	1.9	0.4	-0.1	1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.9	-0.7	-0.9	0.0
Leg fat-free mass (left)	0.4	2.0	3.3	1.8	0.3	1.7
Relative age voice broke	0.4	0.6	1.3	0.6	1.1	-0.3
Multivitamins +/- minerals	0.4	0.5	1.0	1.0	0.8	0.2
Supplements: Glucosamine	0.4	0.5	1.1	-0.3	-1.1	0.4
Leg predicted mass (left)	0.4	2.1	3.2	1.8	0.3	1.7
Hair/balding pattern: Pattern 2	0.4	0.5	0.7	0.8	0.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.5	0.1	0.1	1.6
Tense / ‘highly strung’	0.4	0.7	1.6	0.7	-0.2	1.3
Headache pain in last month	0.4	0.7	1.6	0.7	1.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.7	-1.3	-0.4	-0.7
Age at first live birth	0.4	0.7	1.2	-1.1	-0.2	-0.9
Eye problems/disorders: None of the above	0.4	0.4	0.9	-0.3	-1.0	-0.5
Illnesses of father: Heart disease	0.4	0.6	1.5	-0.5	-0.3	-1.2
Leg fat-free mass (right)	0.4	2.0	3.5	1.9	0.1	1.6
Medication: Aspirin	0.4	0.6	1.0	1.0	0.4	-0.8
Medication: Gliclazide	0.4	0.4	0.8	0.5	0.9	0.4
Leg predicted mass (right)	0.4	2.0	3.4	1.8	0.1	1.6
Hearing aid user	0.4	0.4	0.9	0.9	0.0	0.6
Medication: Paracetamol	0.4	0.6	1.3	0.5	0.6	1.1
Impedance of whole body	0.4	2.3	3.5	-1.8	0.3	-1.9
Bipolar Disorder or Schizophrenia	0.3	0.8	1.8	0.6	0.4	1.3
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	-0.9	-0.1	0.4
Irritable Bowel Disease (IBD)	0.3	0.6	0.9	-0.9	-0.7	-0.7
HbA1C	0.3	0.3	0.7	0.5	-0.8	-0.1
Triglycerides	0.3	0.5	1.2	0.1	1.1	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.0	0.5	1.0	0.8
Relative age of first facial hair	0.3	0.7	2.1	1.4	-0.2	0.2
High blood pressure (mother)	0.3	0.4	1.1	1.1	0.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	0.6	0.8	-0.3
Financial difficulties in last 2 years	0.3	0.3	0.7	-0.8	0.6	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.5	0.4	0.9
Length of working week for main job	0.3	0.4	0.5	-0.5	-0.7	0.6
Pulse wave reflection index	0.3	0.4	0.7	0.3	0.8	-0.5
Birth weight	0.3	0.6	1.4	-0.5	-1.2	-0.1
Worry too long after embarrassment	0.3	0.5	1.1	1.1	-0.3	0.4
Pulse wave peak to peak time	0.3	0.3	0.5	-0.2	-0.6	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.5	0.5	0.5	-0.7
Migraine (self-reported)	0.3	0.4	0.8	0.4	0.9	0.4
Mean time to correctly identify matches	0.3	0.6	1.3	1.2	0.6	0.4
Alcohol intake frequency.	0.3	0.7	1.9	0.4	-1.4	-0.1
Breast cancer (self-reported)	0.3	0.4	0.6	0.1	-0.8	-0.8
Medication: Lisinopril	0.3	0.4	0.7	0.8	0.2	-0.6
Average weekly beer plus cider intake	0.3	0.4	0.5	0.6	-0.7	0.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.0	1.0	0.1	0.2
Diastolic blood pressure, automated reading	0.3	1.0	2.6	0.5	1.6	0.3
Alcohol drinker status: Previous	0.3	0.3	0.6	-0.7	-0.5	0.3
Ulcerative Colitis (UC)	0.2	0.3	0.7	-0.8	-0.5	0.2
Major Depression (MDD)	0.2	0.3	0.6	-0.8	-0.4	0.3
Breast Cancer	0.2	0.4	0.8	-0.1	0.6	-0.9
Neuroticism (2016)	0.2	0.3	0.7	0.0	0.8	0.4
Primary Biliary Cirrhosis	0.2	0.3	0.8	0.2	-0.3	0.9
Blood Red Count	0.2	2.2	2.9	-1.7	1.5	-1.2
Cardiovascular Disease	0.2	0.8	1.6	0.8	1.3	-0.1
Diabetes (mother)	0.2	0.2	0.6	0.1	-0.7	0.2
Impedance of leg (right)	0.2	0.9	1.0	-1.0	1.0	-0.9
Townsend deprivation index at recruitment	0.2	0.2	0.6	0.1	-0.8	0.2
Current tobacco smoking	0.2	0.4	1.0	0.3	1.0	-0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.4	-0.6	0.4
Number of incorrect matches in round	0.2	0.4	0.7	0.9	-0.5	0.5
Forced vital capacity (FVC)	0.2	0.6	1.1	-1.0	0.4	-0.7
Illnesses of siblings	0.2	0.2	0.4	-0.2	0.5	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.8	-0.3	0.4
Illnesses of mother	0.2	0.2	0.3	-0.6	0.1	-0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.3	0.6	-0.5
Gout (self-reported)	0.2	0.3	0.8	-0.2	0.9	-0.0
Medication: Amlodipine	0.2	0.3	0.4	0.6	0.6	-0.3
Comparative height size at age 10	0.2	1.0	2.7	0.2	0.6	1.6
Family relationship satisfaction	0.2	0.2	0.4	-0.1	0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.2	0.4	0.4	1.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	-0.1	0.9	0.2
Mineral and other dietary supplements	0.2	0.3	0.3	-0.4	-0.5	-0.5
Asthma (self-reported)	0.2	0.3	0.7	0.8	-0.1	0.5
Smoking status: Current	0.2	0.3	0.5	0.7	0.6	-0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.5	0.7	0.3
Medication: Bendroflumethiazide	0.2	0.3	0.8	0.3	-0.2	0.9
Prostate Cancer	0.1	0.1	0.2	0.0	-0.3	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.4	-0.1	0.0	-0.7
Waist Hip Ratio (WHR)	0.1	0.6	1.3	1.1	-0.1	0.7
Lung FEV1/FVC ratio	0.1	0.5	0.6	-0.8	-0.5	-0.7
Hand grip strength (left)	0.1	0.4	1.0	0.3	-1.0	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.3	0.2	-0.5
Pack years adult smoking proportion	0.1	0.2	0.6	-0.2	0.8	-0.3
Hand grip strength (right)	0.1	0.3	0.4	-0.1	-0.7	-0.6
Medication: Atenolol	0.1	0.1	0.2	0.3	0.1	-0.5
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.2	-0.6	-0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.2	0.2	0.6
Impedance of leg (left)	0.1	0.7	0.9	-0.8	0.8	-0.9
Allergy	0.1	0.3	0.8	0.9	-0.1	0.1
Pain all over the body in last month	0.1	0.2	0.4	-0.1	0.1	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.1	-1.0	-0.1	-0.6
Asthma	0.1	0.3	0.6	0.8	-0.0	0.4
Depression (self-reported)	0.1	0.1	0.2	-0.2	0.3	0.5
Standing height	0.1	0.7	1.8	0.3	1.3	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.3	0.3	-0.3
Peak expiratory flow (PEF)	0.1	0.3	0.4	-0.6	-0.6	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.4	0.5	-0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.1	-0.3	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.5	-0.7	0.4	-0.5
Comparative body size at age 10	0.1	0.2	0.4	-0.3	-0.1	0.6
Medication: Allopurinol	0.1	0.1	0.2	0.4	0.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.0	-0.3	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.0	-0.1	0.5
Wears glasses or contact lenses	0.1	0.1	0.2	-0.3	0.4	0.1
Medication: Blood pressure	0.1	0.2	0.3	0.5	0.6	0.2
Fractured/broken bones in last 5 years	0.1	0.1	0.1	0.1	-0.3	-0.4
Pack years of smoking	0.1	0.2	0.5	-0.1	0.7	-0.3
Heel T-Score	0.0	0.4	0.9	-0.1	0.9	0.5
Height	0.0	0.8	1.9	0.4	1.4	0.5
Tanning	0.0	0.3	0.6	0.3	0.5	0.8
Supplements: Zinc	0.0	0.1	0.1	-0.4	-0.1	0.1
Sitting height	0.0	0.3	0.8	-0.0	0.9	0.2
Worrier / anxious feelings	0.0	0.1	0.1	0.2	0.4	0.3
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	0.2	0.2	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.2	0.3	-0.5	0.3	-0.3
Medication: Seretide 50 evohaler	0.0	0.0	0.1	0.3	-0.0	0.3
Eye problems/disorders: Cataract	0.0	0.1	0.1	-0.1	0.2	-0.4
Miserableness	0.0	0.1	0.1	0.2	0.2	0.4

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Trait associations