Hub : Genes

EPB41

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1510	0.0485	1.3e-04	0.055	NA	0.048	NA	0.053	5.1e-05	NA	1.4e-04	NA	7.0e-05
2	GTEx	Testis	0.1530	0.0490	1.2e-04	0.120	NA	0.101	NA	0.119	5.7e-06	NA	3.0e-05	NA	6.1e-06
3	NTR	Blood	0.0139	0.0067	1.1e-02	0.002	0.006	0.001	0.006	0.001	5.2e-02	4.8e-03	1.2e-01	3.5e-03	1.2e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.0586	0.0203	1.7e-05	0.058	0.043	0.055	0.049	0.058	5.7e-08	3.0e-06	1.2e-07	6.6e-07	5.4e-08
5	TCGA	Prostate Adenocarcinoma	0.0656	0.0302	2.6e-04	0.050	0.039	0.049	NA	0.055	5.3e-06	5.3e-05	7.3e-06	NA	1.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.6	2.5	3.8	1.4	1.6	1.3	-2.0	-1.5
Bipolar Disorder or Schizophrenia	2.2	5.5	14.8	3.8	-1.6	-3.0	0.1	-1.1
Depressed Affect (Nagel 2018)	0.4	0.8	2.4	-0.0	-0.6	-1.1	1.6	-0.1
Depression (Nagel 2018)	0.7	1.1	2.0	1.1	-0.6	-1.2	0.6	1.4
Intelligence (Savage-Jansen 2018)	3.6	11.2	33.3	0.6	2.7	1.1	-3.7	5.8
Neuroticism (Nagel 2018)	0.5	1.2	4.1	-0.6	-0.7	-0.8	2.0	0.5
Schizophrenia (2018)	5.0	10.4	24.0	3.8	-3.3	-4.9	1.7	-0.1
Schizophrenia vs Biploar Disorder	4.6	6.1	10.7	0.2	-3.3	-3.2	2.9	1.0
Worry (Nagel 2018)	0.3	0.7	2.9	-0.0	-0.7	-0.2	1.7	0.0
Alzheimer’s Disease (in mother)	0.4	0.4	0.6	0.7	-0.7	-0.7	-0.1	-0.8
Alzheimer’s Disease (in father)	3.4	3.6	7.0	0.4	2.1	1.3	-2.6	2.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	0.7	-0.2	-0.6	-0.8	0.3
Crohns Disease (2017)	1.5	3.3	7.3	-0.9	2.7	2.6	-0.9	0.8
Irritable Bowel Disease (IBD)	1.5	3.6	7.0	-1.4	2.6	2.6	-1.0	1.2
Ulcerative Colitis (UC)	0.9	1.6	2.6	-1.2	1.5	1.6	-0.6	1.2
Major Depression (MDD)	0.2	0.2	0.4	0.3	0.6	0.4	-0.7	0.1
Reaction Time	0.2	0.4	1.3	-0.0	0.2	1.1	0.5	-0.6
Verbal and Numeric Reasoning (VNR)	2.4	5.7	18.3	0.4	1.5	0.9	-2.6	4.3
Breast Cancer	0.6	1.5	3.8	0.8	1.5	0.6	-1.9	0.5
Ovarian Cancer	1.0	1.3	3.8	0.3	1.0	1.9	-0.8	-1.1
Prostate Cancer	0.6	0.8	2.9	0.8	0.2	0.3	-0.6	-1.7
Age at First Birth	1.6	2.3	8.1	2.9	-0.4	-1.1	-1.1	1.0
Bipolar Disorder (2011)	3.2	3.1	5.0	0.6	2.2	2.2	-2.2	0.2
Body Mass Index (BMI) (2010)	0.3	0.5	1.3	1.1	-0.6	-0.0	-0.8	0.2
Coronary Artery Disease (CAD)	0.2	0.2	0.8	-0.1	0.9	0.1	0.4	-0.0
Crohns Disease (2012)	0.8	1.4	2.9	0.4	1.6	1.7	-0.9	0.6
Mean Putamen Volume	1.2	1.4	3.9	1.3	1.0	0.0	-2.0	0.4
Fasting Glucose	0.1	0.1	0.2	-0.4	-0.1	-0.4	-0.2	0.4
HbA1C	0.3	0.3	0.9	-0.5	0.2	0.0	1.0	-0.6
HDL Cholesterol	1.3	2.1	5.3	0.5	-1.0	-1.1	2.3	-1.7
LDL Cholesterol	1.1	1.8	5.7	-2.4	-0.0	0.8	1.6	0.5
Lupus	0.3	0.4	0.9	-1.0	0.0	0.7	0.5	0.7
Neuroticism (2016)	0.7	1.0	3.8	-0.6	0.3	0.7	0.5	-2.0
Primary Biliary Cirrhosis	1.4	2.0	4.7	-1.7	1.5	2.2	0.5	0.2
Rheumatoid Arthritis	0.7	1.0	2.6	1.2	-0.8	-1.6	0.0	0.6
Schizophrenia (2014)	4.1	9.1	19.4	3.8	-3.1	-4.4	1.5	0.3
Triglycerides	0.3	0.5	1.8	-1.3	-0.3	-0.4	0.5	0.2
Type 2 Diabetes (T2D) (2012)	2.4	2.8	5.9	2.4	-1.6	-2.3	0.4	-0.3
Ulcerative Colitis	2.0	2.8	5.3	-0.9	2.1	2.3	-1.8	0.7
Blood Eosinophil Count	0.0	0.3	1.0	0.4	-0.2	1.0	-0.6	-0.5
Blood Platelet Count	1.6	18.2	38.8	-1.3	6.2	5.5	-4.5	0.1
Blood Red Count	0.4	3.7	12.9	0.4	-1.1	-2.0	-0.6	3.6
Blood White Count	0.1	0.7	1.7	-0.6	1.3	0.8	-0.9	-0.1
Heel T-Score	1.0	7.9	17.6	0.9	-2.2	-4.2	0.6	4.0
BMI	1.0	5.7	11.3	1.7	-2.5	-2.7	0.8	3.4
Height	0.3	5.7	11.3	-2.0	3.4	3.1	-1.6	-1.1
Waist Hip Ratio (WHR)	1.0	4.7	12.7	-2.0	-1.6	-0.8	3.6	1.9
Systolic Blood Pressure	1.8	9.1	17.9	-4.2	1.1	4.1	2.5	-1.7
Smoking Status	0.3	0.7	1.5	-1.2	1.0	0.1	0.5	-0.9
Allergy or Eczema	1.6	4.2	6.8	-2.1	2.6	1.9	-2.5	-0.1
Cardiovascular Disease	2.1	7.1	22.6	-2.7	-2.3	0.1	4.8	0.3
Hypothyroidism (self reported)	0.3	0.7	3.3	-0.4	0.1	0.2	0.2	-1.8
Respiratory disease	0.2	0.4	1.0	1.0	0.8	0.0	-0.5	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	-0.5	-0.7	-0.9	0.2	0.7
Lung FEV1/FVC ratio	0.2	0.9	4.3	0.2	-0.5	-0.3	0.1	2.1
Lung FVC	0.2	1.0	4.1	-0.6	-0.2	-0.7	-0.2	2.0
Neuroticism	0.3	0.8	2.5	-0.7	0.3	0.3	1.6	-0.9
Chronotype (morning person)	0.5	1.2	2.7	1.1	-0.6	-1.6	-1.0	0.8
Hair Pigment	0.3	7.2	18.6	-4.3	2.0	3.4	1.4	-0.3
Tanning	0.1	1.0	3.2	0.1	0.8	0.8	-0.8	-1.8
Hand grip strength (left)	0.4	1.1	1.7	-1.2	0.5	1.0	1.3	1.1
Number of treatments/medications taken	1.4	2.5	4.8	-0.2	-2.2	-1.4	2.0	1.3
Average weekly spirits intake	2.7	3.4	7.0	-0.4	2.6	1.3	-2.4	1.5
Sensitivity / hurt feelings	0.8	1.3	3.6	-0.5	-1.3	-0.7	1.9	0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.4	0.8	0.6	-0.2	-0.0
Hearing difficulty/problems: Yes	1.8	2.7	5.1	2.0	-2.1	-2.3	0.2	0.1
Relative age of first facial hair	0.1	0.3	1.2	0.4	-0.4	0.0	1.1	0.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.0	1.3	-0.8	-0.3	-0.0	-1.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	0.9	-0.7	-0.2	0.3	-0.5
Ever had hysterectomy (womb removed)	1.5	1.7	2.8	-1.5	-1.0	0.1	1.6	-1.7
Systolic blood pressure, automated reading	1.1	3.1	5.3	-2.2	0.1	2.3	1.9	-1.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	1.0	-0.4	-0.1	-0.7	-0.2
Angina	1.0	1.3	2.3	-1.3	-1.5	-0.5	1.3	0.6
Medication for hormone replacement therapy	0.4	0.5	1.3	1.1	0.1	-0.4	-0.9	0.2
Vitamin and mineral supplements	0.3	0.4	1.1	0.4	-1.0	-0.5	0.8	-0.2
Supplements: Zinc	0.5	0.6	2.0	0.2	0.9	0.2	-1.4	0.3
Medication: Co-codamol	0.2	0.3	0.6	-0.4	0.5	0.8	0.1	-0.5
Medication: Metformin	0.2	0.2	0.8	-0.0	0.1	0.5	-0.9	0.3
Diabetes (father)	0.5	0.6	1.1	-0.5	0.8	-0.4	-0.8	-1.0
Diabetes (mother)	0.5	0.6	1.3	1.0	0.6	-0.7	-1.1	0.0
Severe depression (siblings)	0.5	0.6	2.3	-0.7	-0.0	0.2	-0.0	1.5
Pack years adult smoking proportion	4.0	6.1	13.3	-0.7	-3.0	-1.8	3.6	-2.0
Impedance of leg (right)	0.8	3.8	12.3	-3.5	1.4	1.7	0.9	-1.1
Leg fat-free mass (left)	0.3	1.3	2.9	1.7	0.3	-0.3	-1.3	1.4
Trunk fat percentage	1.0	3.8	18.0	0.4	-0.7	-0.7	-0.2	4.2
Hand grip strength (right)	0.4	1.1	2.2	-0.8	1.5	1.5	-0.1	0.4
Townsend deprivation index at recruitment	0.3	0.4	1.5	-0.4	0.4	0.0	0.1	-1.2
Current tobacco smoking	0.5	0.8	2.0	-1.4	1.2	-0.2	0.2	0.6
Average weekly fortified wine intake	1.0	1.2	2.2	1.5	-0.3	-1.2	-0.4	1.5
Maternal smoking around birth	3.2	4.6	10.9	-2.2	3.3	2.3	-0.9	-1.1
Fed-up feelings	0.7	1.2	3.7	-1.9	0.6	0.9	1.0	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.4	1.2	-0.5	-1.1	0.3	1.0
Relative age voice broke	0.5	0.8	1.4	0.2	-0.8	-1.1	1.0	1.2
Taking other prescription medications	1.1	1.8	2.9	0.2	-1.7	-1.6	1.2	1.4
Age when periods started (menarche)	1.7	4.1	7.5	-1.4	-2.7	-1.6	2.7	-1.1
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	4.3	0.2	-2.1	-1.4	0.8	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.3	0.2	0.4	-1.0	-0.8	1.5
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.0	-0.3	-0.9	-0.4	1.0	2.0
Qualifications: CSEs or equivalent	0.1	0.2	0.7	-0.8	0.3	0.1	0.0	-0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.3	0.2	0.5	-0.2	-0.1
High blood pressure	2.7	7.4	17.2	-4.2	0.5	3.8	2.0	1.1
Hayfever, allergic rhinitis or eczema	1.8	4.0	7.3	-1.4	2.7	1.7	-2.7	0.7
Multivitamins +/- minerals	0.6	0.8	2.9	-1.7	0.6	-0.1	0.5	0.5
Stomach or abdominal pain in last month	0.7	0.9	1.7	-0.3	-1.2	-1.1	1.3	-0.2
Supplements: Glucosamine	1.1	1.4	3.1	1.4	-0.5	-1.8	-0.1	1.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.1	1.1	-0.1	0.2	-1.0	0.7
Medication: Atenolol	1.4	1.8	3.5	-1.9	-0.3	1.4	1.6	-0.9
Medication: Levothyroxine sodium	0.8	1.4	3.6	0.4	-1.0	-0.8	1.2	-1.9
Sitting height	0.9	6.6	11.7	-1.3	3.4	3.0	-2.8	1.6
Chronic bronchitis/emphysema (father)	1.0	1.2	3.0	-1.7	-0.3	0.8	0.4	-1.4
High blood pressure (mother)	0.4	0.6	1.4	-1.2	0.3	0.8	-0.1	-1.0
Body mass index (BMI)	0.8	3.4	9.9	1.7	-1.5	-1.4	0.2	3.1
Impedance of leg (left)	0.8	3.8	13.0	-3.6	1.4	1.7	0.9	-0.5
Leg predicted mass (left)	0.3	1.4	3.0	1.7	0.3	-0.3	-1.4	1.4
Trunk fat mass	0.8	3.5	16.0	0.6	-0.6	-0.7	-0.3	4.0
Waist circumference	0.8	3.0	11.7	0.5	-1.2	-0.5	1.1	3.4
Number of incorrect matches in round	1.4	2.4	3.8	0.0	1.7	1.4	-1.9	-1.9
Past tobacco smoking	0.4	0.7	1.6	-0.5	-1.3	-0.5	0.9	-0.8
Alcohol usually taken with meals	0.6	0.9	2.6	1.6	-1.3	-0.6	-0.0	-0.0
Nervous feelings	0.2	0.4	0.9	-0.9	0.4	0.5	0.8	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	-1.1	0.8	0.9	0.6	-0.0
Hearing difficulty/problems with background noise	3.2	5.1	10.6	3.2	-2.3	-2.8	-0.8	1.2
Hair/balding pattern: Pattern 2	1.9	2.5	6.3	-2.5	1.4	1.8	0.5	0.7
Had menopause	0.3	0.3	0.6	0.7	-0.7	0.3	0.2	0.8
Had other major operations	0.1	0.2	0.4	0.6	0.4	0.4	-0.3	0.3
Forced vital capacity (FVC)	0.5	1.9	4.2	-2.0	1.7	0.8	-0.9	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.9	0.5	0.5	-1.0	-1.0	2.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	2.6	-0.1	-1.2	-1.5	1.6	0.7
Qualifications: None of the above	2.4	5.2	10.3	-1.4	-2.4	-0.6	3.2	-2.8
Financial difficulties in last 2 years	0.2	0.3	1.1	0.2	-0.3	-0.5	1.0	-0.4
Mouth/teeth dental problems	1.5	2.4	5.5	-2.4	1.9	1.0	-1.2	0.3
Heart attack	0.7	0.9	3.2	-1.8	-0.4	0.8	0.7	-0.2
Allergy	1.2	2.7	6.5	0.9	-2.5	-1.4	1.9	-0.7
Pain all over the body in last month	1.5	1.6	5.1	0.6	0.1	-1.5	-0.0	2.2
Diabetes (self-reported)	0.2	0.4	1.0	-1.0	0.3	0.5	-0.6	0.4
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	6.6	0.1	2.1	0.6	-2.2	2.6
Medication: Ramipril	2.2	2.8	5.9	-2.4	0.1	1.3	1.7	1.9
Medication: Simvastatin	2.3	3.5	8.5	-2.2	-1.9	0.2	2.9	0.6
Fluid intelligence score	3.5	7.3	13.9	0.0	2.8	1.4	-3.6	3.7
Illnesses of siblings	0.4	0.5	1.4	0.8	1.2	-0.5	-0.7	-0.0
Neuroticism score	0.4	0.9	1.8	-0.7	1.1	1.3	0.8	-0.5
Weight	0.5	2.5	10.4	1.2	-0.3	-0.5	-0.6	3.2
Impedance of arm (right)	0.2	1.1	2.0	-1.3	1.4	0.9	-0.7	-0.7
Arm fat percentage (right)	1.1	4.5	15.4	1.6	-1.3	-1.6	0.0	3.9
Trunk fat-free mass	0.1	0.6	1.7	1.3	0.6	0.2	-0.8	0.1
Hip circumference	0.6	2.4	10.7	1.1	-0.2	-0.2	-0.6	3.3
Time employed in main current job	0.2	0.3	0.4	0.5	0.2	0.6	-0.5	-0.6
Alcohol intake versus 10 years previously	0.2	0.4	1.5	-1.2	0.4	0.2	0.3	-0.2
Father’s age at death	2.9	3.9	11.1	3.3	0.5	-1.4	-2.4	0.6
Worrier / anxious feelings	0.6	1.2	3.5	0.0	-1.4	0.7	1.9	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	3.2	0.7	-1.3	-1.8	0.8	0.9
Falls in the last year	4.3	5.8	12.6	0.1	3.0	2.1	-3.6	-1.7
Hair/balding pattern: Pattern 3	1.5	2.2	3.4	1.4	-1.7	-1.9	0.5	1.5
Number of live births	2.4	3.3	5.8	-2.3	-0.4	1.3	2.4	-2.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.8	-1.7	1.2	0.4	-0.6	1.0
Pulse rate	0.7	1.2	3.0	-0.4	1.0	-0.3	-1.3	1.7
Happiness	0.9	1.1	2.2	0.4	-1.0	-1.2	1.5	0.8
Noisy workplace	0.7	0.9	1.6	1.1	-1.1	-1.2	0.7	0.1
Qualifications: A levels/AS levels or equivalent	3.1	6.9	21.6	1.9	2.8	0.5	-4.7	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	7.1	-0.5	0.3	-0.5	-1.1	2.7
Mouth/teeth dental problems: Dentures	0.6	1.1	2.6	0.3	-1.6	0.4	1.3	-1.0
Asthma	0.5	1.0	3.4	0.3	0.9	0.9	-0.1	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	4.9	2.2	-0.8	-2.2	-0.4	-1.0
Medication: Cholesterol lowering	3.6	5.6	15.4	-2.2	-2.7	-0.3	3.9	0.3
Depression (self-reported)	1.3	1.6	4.8	0.3	-1.5	-0.9	2.2	0.4
Medication: Lansoprazole	1.6	1.9	5.7	-0.6	-1.1	-1.4	0.4	2.4
Prospective memory result	0.7	0.9	2.0	0.2	-1.4	0.3	1.4	-0.7
Lung cancer (father)	0.5	0.5	1.5	-0.4	-1.2	-0.6	0.2	0.8
Illnesses of mother	0.5	0.6	1.7	-1.0	1.3	0.5	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.8	-0.8	0.9	0.1	-1.4	2.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	0.2	-0.5	-0.1	-0.4	-0.8
Impedance of arm (left)	0.2	1.0	2.7	-1.6	1.2	0.7	-0.6	0.2
Arm fat mass (right)	0.8	3.3	11.9	1.3	-1.1	-1.2	0.1	3.4
Trunk predicted mass	0.1	0.6	1.6	1.2	0.7	0.3	-0.8	0.1
Standing height	0.3	3.0	6.7	-1.2	2.6	1.9	-1.7	0.1
Length of working week for main job	1.8	2.0	4.8	2.2	-1.4	-1.4	0.8	-0.5
Exposure to tobacco smoke at home	1.1	1.3	4.2	-2.0	1.0	0.6	-0.3	0.9
Breastfed as a baby	2.9	3.6	8.7	1.3	-2.0	-1.2	1.5	3.0
Tense / ‘highly strung’	0.8	1.3	3.2	-1.8	1.5	1.0	0.3	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	2.6	0.7	-1.4	-1.6	1.6	0.8
Hair/balding pattern: Pattern 4	0.9	2.2	5.0	-1.3	-0.7	-0.1	1.9	-2.2
Birth weight of first child	0.7	1.2	2.6	1.6	-0.5	-1.3	-0.1	1.2
Peak expiratory flow (PEF)	1.0	2.3	4.1	-1.4	2.0	1.4	-1.8	0.5
Pulse wave reflection index	1.1	1.4	5.2	0.2	0.0	1.3	0.2	-2.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.6	1.6	-0.2	-0.3	-0.1	0.1
Loud music exposure frequency	0.3	0.4	1.2	1.1	-0.0	-0.3	-0.3	0.6
Qualifications: O levels/GCSEs or equivalent	2.6	4.2	7.4	0.5	2.3	0.6	-2.7	2.7
Mouth/teeth dental problems: Bleeding gums	3.4	4.5	13.7	3.7	-2.4	-1.6	0.4	-0.5
Blood clot in the leg (DVT)	0.6	0.8	2.7	-0.5	-0.9	-0.4	1.6	-0.0
Medication: Paracetamol	1.2	2.0	4.2	1.1	-1.6	-2.0	0.1	-1.4
Headache pain in last month	0.6	1.0	3.9	-0.2	-0.1	-0.6	1.0	-2.0
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	5.4	1.3	1.9	-0.4	-2.3	0.5
Glaucoma (self-reported)	0.9	1.1	1.5	-1.1	-0.9	-1.0	1.2	0.9
Gout (self-reported)	0.5	0.7	2.5	-0.3	0.7	-0.2	-0.5	1.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	6.9	0.4	-0.9	-0.3	1.1	-2.6
Medication: Amlodipine	1.2	1.7	4.8	-2.2	0.4	1.7	0.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.6	0.2	-0.6	-1.2	0.7	1.3
Birth weight	0.1	0.2	0.5	0.7	-0.3	0.3	0.1	-0.5
Chronic bronchitis/emphysema (mother)	2.1	2.4	5.1	-2.3	1.6	2.1	-0.2	0.3
High blood pressure (siblings)	0.1	0.2	0.5	-0.2	-0.3	0.7	-0.5	0.1
Forced vital capacity (FVC), Best measure	0.8	3.1	4.9	-1.6	2.0	1.0	-1.7	2.2
Body fat percentage	1.1	4.4	19.6	0.6	-1.0	-0.9	-0.0	4.4
Leg fat percentage (right)	0.9	3.3	10.9	0.5	-1.7	-1.2	1.1	3.3
Arm fat-free mass (right)	0.1	0.7	2.0	1.1	-0.0	-0.2	-0.4	1.4
Exposure to tobacco smoke outside home	3.0	4.0	10.9	-3.3	1.3	1.9	0.2	2.0
Comparative body size at age 10	2.5	6.9	23.1	4.8	-0.1	-2.4	-2.2	0.5
Number of full brothers	0.5	0.6	2.5	-1.6	0.0	0.0	0.7	-0.1
Worry too long after embarrassment	1.0	1.7	4.6	0.5	1.4	2.2	-1.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	10.0	3.2	0.5	-0.9	-1.5	0.4
Wheeze or whistling in the chest in last year	0.6	1.1	2.9	-1.2	-0.6	-0.1	1.7	0.8
Number of children fathered	0.5	0.6	2.6	0.6	-0.1	0.4	-0.2	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.0	-0.0	-1.4	-1.1	1.0	1.4
Age at first live birth	0.1	0.1	0.3	0.5	-0.3	0.1	0.1	0.6
Pulse wave peak to peak time	0.2	0.3	0.8	-0.3	0.9	0.5	0.1	0.6
Health satisfaction	1.5	1.9	2.7	-0.2	-1.5	-1.4	1.6	1.6
Shortness of breath walking on level ground	3.4	4.0	9.8	-1.5	-2.4	-1.6	3.1	0.2
Qualifications: College or University degree	2.2	6.9	14.4	1.4	3.0	1.9	-3.8	2.3
Eye problems/disorders: None of the above	0.5	0.6	1.6	0.8	0.7	0.2	-1.3	0.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.1	-0.4	1.8	1.6	-0.3	-0.8
Emphysema/chronic bronchitis	0.8	0.9	1.9	-1.0	0.4	1.2	0.1	-1.4
Medication for pain relief, constipation, heartburn	2.0	3.4	7.3	-0.5	2.5	2.7	-1.8	0.5
Neck or shoulder pain in last month	0.1	0.2	0.4	0.4	-0.1	-0.4	-0.4	-0.7
Medication: Blood pressure	1.0	1.7	3.2	-1.4	-1.4	0.9	1.8	-0.7
Angina (self-reported)	1.2	1.5	2.6	-1.4	-1.6	-0.4	1.6	0.6
Migraine (self-reported)	4.4	5.5	15.9	-4.0	2.3	2.3	-0.6	-0.8
Medication: Ibuprofen	3.3	3.9	9.4	2.9	-1.2	-3.1	0.1	-0.6
Medication: Allopurinol	0.9	1.2	3.5	-0.2	1.0	0.7	-0.9	1.9
Medication: Omeprazole	0.2	0.2	0.4	-0.1	-0.7	-0.4	0.5	-0.6
Medication: Seretide 50 evohaler	0.5	0.6	1.5	-0.6	-0.5	0.4	1.2	-0.9
Mean time to correctly identify matches	0.1	0.2	1.0	0.4	-0.1	1.0	0.0	-0.2
Heart disease (mother)	0.5	0.6	1.4	-0.1	-0.8	-0.8	0.5	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.1	-0.3	0.6	1.4	-0.9	-0.9
Whole body fat mass	0.8	3.5	15.7	0.8	-0.7	-0.7	-0.2	4.0
Leg fat mass (right)	0.8	2.9	11.2	1.0	-1.2	-0.9	0.4	3.4
Arm predicted mass (right)	0.1	0.6	1.8	1.0	0.1	-0.0	-0.3	1.3
Pulse rate, automated reading	0.7	2.4	8.4	-1.1	-0.4	-1.4	0.2	2.9
Alcohol intake frequency.	0.5	1.1	1.8	-1.2	-1.0	-1.0	1.4	-0.4
Comparative height size at age 10	0.5	2.6	5.6	0.6	2.0	1.2	-1.4	-2.4
Number of full sisters	1.0	1.3	2.2	0.9	-1.5	-1.0	0.8	-1.3
Suffer from ‘nerves’	0.4	0.6	1.1	-0.2	-0.3	0.8	1.1	-1.0
Overall health rating	3.3	7.0	10.5	-1.1	-2.7	-2.6	3.0	3.2
Chest pain or discomfort	0.7	1.1	3.2	-1.1	0.4	0.5	0.8	1.8
Had major operations	0.7	0.8	1.6	0.9	1.0	0.7	-1.3	0.6
Age at last live birth	0.4	0.6	1.8	-1.0	-0.1	0.4	1.3	-0.2
Family relationship satisfaction	0.1	0.1	0.3	-0.2	0.3	0.6	0.5	0.2
Leg pain on walking	0.0	0.1	0.2	0.1	-0.0	-0.4	-0.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.0	1.0	-1.4	-1.3	0.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.2	0.8	0.7	0.0	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	0.3	-0.1	-0.4	0.5	-0.8
Medication: Aspirin	3.4	4.5	8.9	-2.7	-1.6	-0.2	3.0	1.9
Supplements: Vitamin C	0.6	0.8	1.7	0.5	0.9	1.0	-1.3	0.1
Knee pain experienced in last month	0.8	1.2	2.6	1.6	0.4	-0.3	-1.4	1.1
Hypertension (Self-reported)	2.3	6.5	15.4	-3.9	-0.1	3.1	2.5	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.6	-1.3	-0.4	-0.2	0.4	1.6
Illnesses of father: Heart disease	0.1	0.1	0.5	-0.0	-0.7	-0.0	0.4	-0.2
Illnesses of siblings: Diabetes	0.5	0.7	1.3	-1.1	0.2	0.6	-0.7	1.1
Smoking status: Previous	0.2	0.2	0.5	0.5	0.6	0.7	-0.0	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.7	14.7	-1.6	3.8	1.8	-2.7	0.4
Whole body fat-free mass	0.1	0.8	2.2	1.5	0.5	0.1	-1.1	0.7
Leg fat-free mass (right)	0.3	1.4	3.0	1.7	0.3	-0.3	-1.3	1.5
Arm fat percentage (left)	1.3	5.4	19.4	1.4	-1.6	-1.8	0.3	4.4
Average weekly red wine intake	0.2	0.3	0.8	0.5	-0.1	0.3	-0.9	0.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	0.8	0.1	0.5	-0.6	1.1
Mood swings	0.3	0.5	1.9	-0.3	-0.3	-0.2	1.4	-0.5
Loneliness, isolation	0.2	0.3	0.9	0.7	1.0	-0.1	-0.3	-0.0
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.2	0.4	0.4	0.1	0.6
Ever had bowel cancer screening	0.2	0.3	0.8	-0.9	-0.8	0.0	0.3	0.0
Diabetes diagnosed by doctor	0.2	0.4	0.7	-0.6	0.4	0.5	-0.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.6	-0.3	-0.8	-0.8	0.8	1.3
Friendships satisfaction	0.3	0.4	1.3	0.4	-0.1	-0.5	0.3	-1.1
Qualifications: nursing, teaching	5.3	8.3	15.7	-0.5	4.0	3.4	-3.5	1.4
Commuting to job workplace: Walk	1.9	2.1	3.8	1.7	-1.8	-2.0	-0.2	0.5
Eye problems/disorders: Cataract	1.3	1.5	2.4	0.0	-1.6	-1.3	1.4	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.4	0.4	0.1	-0.9	0.2	1.2
Medication for cholesterol	1.5	2.3	4.8	2.1	0.8	-0.6	-2.2	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	-1.3	0.3	-0.6	-0.3	-0.8
Back pain experienced in last month	0.9	1.3	3.5	-1.1	-0.6	-0.6	1.0	-1.9
Mineral and other dietary supplements	0.3	0.4	0.8	-0.7	0.6	0.4	-0.4	0.9
Breast cancer (self-reported)	0.0	0.0	0.1	-0.1	-0.1	0.4	0.1	0.1
Asthma (self-reported)	0.5	1.0	2.8	0.5	1.0	0.9	-0.3	1.7
Osteoporosis (self-reported)	0.5	0.6	1.2	1.1	-0.8	-0.2	0.1	-1.1
Osteoarthritis (self-reported)	1.9	2.4	7.4	1.4	-0.8	-1.3	0.6	2.7
Medication: Aspirin	2.8	3.6	8.1	-2.8	-1.2	0.3	2.2	1.9
Medication: Gliclazide	0.6	0.7	1.3	-1.0	0.3	0.4	-1.0	-1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	2.1	1.4	-1.2	-1.1	0.6	-0.2
Smoking status: Current	0.5	0.7	2.1	-1.4	1.1	-0.4	0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	6.0	0.1	-1.7	-2.5	-0.1	1.9
Whole body water mass	0.2	0.9	2.5	1.6	0.5	-0.0	-1.1	0.7
Leg predicted mass (right)	0.3	1.4	3.0	1.7	0.4	-0.2	-1.3	1.5
Arm fat mass (left)	1.0	3.9	15.7	1.3	-1.0	-1.1	-0.1	4.0
Number of self-reported non-cancer illnesses	0.5	0.9	1.5	-1.0	-0.5	0.6	1.2	1.2
Average weekly champagne plus white wine intake	0.8	1.1	2.5	1.6	0.5	-0.4	-1.6	-0.5
Miserableness	0.3	0.5	1.6	-0.3	-0.3	-0.6	1.3	0.6
Guilty feelings	0.2	0.2	0.8	0.9	0.1	0.2	0.6	0.3
Wears glasses or contact lenses	0.6	0.7	1.3	-0.5	-1.1	-0.6	1.1	0.7
Ever taken oral contraceptive pill	0.4	0.5	1.1	-0.0	1.0	0.9	-0.0	-0.7
Hearing aid user	1.1	1.2	3.7	0.6	-1.2	-1.9	0.8	-0.0
Mother’s age at death	1.4	1.8	3.7	0.8	-1.4	-1.6	0.3	1.9
Financial situation satisfaction	3.1	3.8	8.0	-1.2	-2.3	-1.3	2.8	1.6
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.7	-1.9	1.2	0.5	-0.4	0.6
Commuting to job workplace: Public transport	1.4	1.7	2.7	1.6	-1.2	-1.6	0.1	1.3
Eye problems/disorders: Glaucoma	0.6	0.8	1.1	-1.0	-0.9	-0.9	1.0	0.2
Medication: Blood pressure	1.6	3.0	8.1	-2.8	-0.0	1.9	1.7	0.5
Pain type(s) experienced in last month: Hip pain	1.1	1.4	4.3	2.1	-1.2	-1.0	-0.6	0.1
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.7	-0.4	-0.8	0.3	1.3	-2.2
High cholesterol (Self-reported)	2.7	4.8	15.0	-1.5	-2.6	-0.1	3.9	0.3
Medication: Bendroflumethiazide	0.4	0.6	1.1	-1.1	-0.3	1.0	0.2	0.8
Medication: Paracetamol	2.2	3.4	6.5	1.7	-2.5	-2.5	1.1	-0.1
Medication: Lisinopril	0.1	0.1	0.2	0.4	-0.4	0.2	0.2	0.5
Medication: Atorvastatin	0.5	0.7	1.1	-0.5	-0.9	-1.1	1.0	0.4
Illnesses of father: High blood pressure	0.7	0.8	2.3	-0.2	0.9	0.3	-1.0	-1.5
Alcohol drinker status: Never	1.2	1.5	3.4	0.1	-1.8	-1.8	0.6	0.6
Ever smoked	1.0	1.7	4.0	0.3	2.0	0.4	-1.6	1.4
Basal metabolic rate	0.2	1.0	2.1	1.3	0.5	0.0	-1.0	1.4
Leg fat percentage (left)	1.1	3.9	13.6	0.5	-1.8	-1.2	1.0	3.7
Arm fat-free mass (left)	0.1	0.5	0.9	0.9	0.4	0.3	-0.9	1.0
Number of operations (self-reported)	1.2	1.8	5.9	2.4	0.3	0.2	-1.4	1.0
Average weekly beer plus cider intake	0.2	0.4	0.7	-0.6	0.8	0.9	-0.1	-0.2
Irritability	0.3	0.5	1.7	-0.5	0.6	-0.0	1.3	0.7
Risk taking	1.2	1.8	3.6	-1.3	1.8	1.9	-0.4	-0.5
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.9	0.3	0.0	0.6	-0.3	0.9
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.5	0.5	-0.5	-0.3	-0.7
Age started oral contraceptive pill	0.6	0.7	2.4	0.1	0.3	1.6	-1.0	0.2
Diastolic blood pressure, automated reading	1.3	4.0	11.2	-3.4	0.4	1.8	2.4	-0.0
Ever depressed for a whole week	1.5	1.9	4.8	0.2	-1.4	-2.2	1.6	0.4
Unable to work because of sickness or disability	0.5	0.6	1.7	-0.2	-0.4	-0.8	0.8	-1.3
Commuting to job workplace: Cycle	0.9	1.0	2.8	-1.7	0.4	0.9	0.3	-1.2
Myopia	0.3	0.4	1.0	-1.0	-0.8	-0.1	0.8	-0.1
Vascular/heart problems diagnosed by doctor	2.3	6.1	13.0	3.6	-0.1	-3.2	-2.2	-1.7
Cholesterol lowering medication	1.4	2.1	4.9	-1.7	-1.2	-0.5	2.2	1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	-0.2	-1.1	-1.1	0.5	0.4
Pain experienced in last month	0.6	0.9	1.7	-1.2	0.6	0.9	-0.4	1.3
Supplements: Calcium	0.6	0.7	2.0	0.9	0.4	-0.1	-1.4	0.6
Basal cell carcinoma (self-reported)	0.8	1.0	1.8	-0.3	-1.0	-1.4	0.4	1.3
Heart attack/myocardial infarction (self-reported)	0.8	1.1	4.0	-2.0	-0.2	0.9	0.7	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.0	-0.8	-0.8	-0.3	1.4	0.1
Heart disease (siblings)	3.7	4.5	12.0	-0.9	-2.4	-1.4	3.5	1.3
Alcohol drinker status: Previous	0.3	0.3	0.6	-0.7	0.7	-0.6	-0.1	-0.4
Pack years of smoking	4.1	5.9	13.1	-0.6	-3.1	-1.5	3.6	-2.1
Impedance of whole body	0.5	2.4	8.0	-2.8	1.5	1.3	0.0	-0.3
Leg fat mass (left)	0.8	3.3	12.9	1.1	-1.3	-0.9	0.2	3.6
Arm predicted mass (left)	0.1	0.6	1.3	1.2	0.3	0.1	-0.8	0.9