Hub : Genes

ESD

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0730 0.0240 3.8e-04 0.052 0.025 0.052 0.037 0.048 5.6e-07 3.9e-04 5.8e-07 2.5e-05 1.4e-06
2 GTEx Artery Aorta 0.1790 0.0650 5.9e-03 -0.005 NA 0.015 NA 0.002 8.8e-01 NA 5.0e-02 NA 2.4e-01
3 GTEx Artery Tibial 0.1211 0.0383 6.0e-04 0.096 NA 0.071 NA 0.083 6.0e-08 NA 3.0e-06 NA 4.9e-07
4 GTEx Stomach 0.2230 0.0830 7.0e-03 0.015 NA 0.003 NA 0.014 6.1e-02 NA 2.1e-01 NA 6.7e-02
5 GTEx Thyroid 0.1080 0.0410 5.0e-03 0.013 NA 0.043 NA 0.035 3.0e-02 NA 2.8e-04 NA 1.1e-03
6 YFS Blood 0.0497 0.0121 2.2e-10 0.047 0.038 0.047 0.044 0.047 4.1e-15 1.7e-12 4.1e-15 2.6e-14 5.0e-15
7 TCGA Brain Lower Grade Glioma 0.0801 0.0339 4.9e-06 0.035 0.050 0.039 NA 0.035 6.7e-05 2.0e-06 2.6e-05 NA 6.5e-05
8 TCGA Uterine Corpus Endometrial Carcinoma 0.1290 0.0610 5.7e-03 0.006 0.029 0.009 NA 0.008 2.2e-01 5.2e-02 1.7e-01 NA 1.9e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.3 0.4 1.5 -0.2 1.2 -0.0 -0.5 0.6 -0.5 -1.0 0.1
Bipolar Disorder or Schizophrenia 0.1 0.2 0.6 0.5 0.8 0.4 0.4 0.2 -0.7 -0.1 0.2
Depressed Affect (Nagel 2018) 1.0 2.2 3.9 -1.7 -2.0 -1.6 -0.0 -1.4 1.7 -1.0 1.5
Depression (Nagel 2018) 0.1 0.1 0.3 -0.1 -0.3 -0.5 -0.3 -0.1 -0.0 -0.5 0.6
Intelligence (Savage-Jansen 2018) 0.7 2.1 5.5 1.7 1.8 1.3 -1.1 1.0 -2.3 1.0 -0.3
Neuroticism (Nagel 2018) 0.4 0.9 3.4 -0.4 -1.8 -0.3 1.4 -0.9 0.9 -0.3 -0.2
Schizophrenia (2018) 0.1 0.3 0.9 0.8 0.0 0.5 0.9 -0.1 -0.5 0.7 0.2
Schizophrenia vs Biploar Disorder 1.0 1.4 3.8 1.4 -0.0 1.2 1.0 1.2 -0.5 2.0 -1.0
Worry (Nagel 2018) 0.8 1.7 4.2 1.4 -0.4 1.5 1.6 1.0 -1.2 0.6 -2.0
Alzheimer’s Disease (in mother) 2.1 2.5 6.5 1.4 0.9 1.7 -0.4 1.4 -1.7 2.6 -1.6
Alzheimer’s Disease (in father) 0.8 0.9 4.6 -0.5 -2.1 0.3 -0.4 0.2 0.8 -0.6 -1.0
Alzheimer’s Disease (including proxy) 0.3 0.4 1.0 0.2 -0.2 0.8 -0.1 0.9 -0.1 1.0 -0.9
Crohns Disease (2017) 1.3 2.8 5.0 2.0 2.0 1.7 0.2 2.0 -2.2 1.3 -1.0
Irritable Bowel Disease (IBD) 0.6 1.5 5.5 0.7 2.3 0.7 -1.5 1.3 -1.2 0.2 -0.7
Ulcerative Colitis (UC) 0.7 1.3 6.9 -0.3 2.6 0.0 -1.8 0.1 -0.5 -0.1 -0.1
Major Depression (MDD) 1.3 1.6 4.7 0.9 -2.2 0.9 0.7 1.2 -1.0 0.7 -1.8
Reaction Time 0.1 0.2 0.8 0.3 -0.3 0.1 0.9 0.1 -0.7 -0.4 -0.2
Verbal and Numeric Reasoning (VNR) 0.2 0.4 2.2 -0.1 0.1 -0.7 -0.6 -0.2 -0.3 0.2 1.5
Breast Cancer 0.1 0.2 0.8 -0.3 0.4 0.2 -0.3 0.9 0.7 -0.5 0.0
Ovarian Cancer 0.1 0.2 0.8 0.2 -0.9 0.3 0.1 0.1 -0.3 -0.4 -0.0
Prostate Cancer 0.5 0.7 3.6 0.2 0.7 0.2 -0.9 -1.9 -0.1 0.8 -0.0
Age at First Birth 0.4 0.6 1.4 -0.8 0.5 -1.1 -0.4 -0.6 -0.2 -1.0 1.2
Bipolar Disorder (2011) 1.9 1.9 6.2 1.6 0.8 1.6 0.4 0.4 -2.5 1.4 -0.7
Body Mass Index (BMI) (2010) 0.3 0.4 1.6 -0.2 -1.3 -0.0 -1.1 -0.3 -0.0 -0.2 0.3
Coronary Artery Disease (CAD) 1.0 1.2 6.5 -0.2 0.8 -0.2 2.5 1.5 0.0 -0.5 0.1
Crohns Disease (2012) 1.5 2.4 4.7 2.0 1.7 1.6 0.8 2.2 -1.8 0.7 -1.0
Mean Putamen Volume 1.0 1.1 2.1 1.2 0.3 1.2 -0.0 1.1 -1.5 1.3 -1.1
Fasting Glucose 0.8 1.0 2.4 -1.4 -1.4 -1.6 -0.4 -0.6 0.8 -0.7 0.4
HbA1C 0.3 0.3 1.1 0.2 -0.1 0.3 -0.9 1.0 0.5 0.3 -0.3
HDL Cholesterol 0.3 0.4 1.2 0.4 1.1 0.5 -0.6 0.3 -0.8 0.7 -0.5
LDL Cholesterol 0.4 0.6 1.3 -0.9 -0.9 -0.3 0.7 -1.1 0.6 -0.9 0.5
Lupus 0.4 0.6 2.0 0.2 0.9 0.3 1.3 0.2 -0.3 -0.2 -1.4
Neuroticism (2016) 0.2 0.4 1.2 0.0 -0.9 -0.3 0.3 -1.1 0.8 -0.2 -0.1
Primary Biliary Cirrhosis 0.3 0.5 1.8 0.7 -1.3 0.2 -0.5 0.5 -1.0 0.3 0.1
Rheumatoid Arthritis 0.8 1.1 4.1 1.5 -0.1 1.3 0.1 0.7 -0.6 2.0 -0.5
Schizophrenia (2014) 0.2 0.4 1.7 0.6 -0.1 0.5 1.3 0.7 -0.1 0.5 -0.5
Triglycerides 0.1 0.1 0.3 0.2 -0.4 0.1 0.6 0.0 -0.2 -0.2 0.3
Type 2 Diabetes (T2D) (2012) 1.0 1.1 4.0 1.2 0.9 0.8 2.0 1.3 -0.6 0.2 -0.2
Ulcerative Colitis 1.0 1.4 3.2 -1.3 0.8 -1.1 -1.8 -0.8 0.7 -1.0 1.6
Blood Eosinophil Count 0.2 1.2 8.0 -0.4 0.4 -0.1 -2.8 -0.8 -0.8 -0.4 0.3
Blood Platelet Count 0.2 2.6 7.9 1.5 2.8 1.9 1.3 1.6 -0.8 0.3 -1.4
Blood Red Count 0.2 1.5 5.1 1.0 1.7 1.0 -0.6 -0.3 -2.2 0.8 -0.9
Blood White Count 0.1 0.8 3.0 0.3 0.5 0.9 0.4 1.1 0.6 -0.1 -1.7
Heel T-Score 0.1 0.4 3.2 -0.0 0.2 -0.3 0.1 -0.3 -0.1 -1.8 -0.1
BMI 0.1 0.8 3.3 -0.9 -1.8 -0.1 -0.7 -0.6 1.0 0.3 -0.8
Height 0.2 3.0 8.1 0.3 2.8 0.4 -2.5 2.1 -0.7 -2.1 -0.0
Waist Hip Ratio (WHR) 0.1 0.5 2.4 0.7 1.1 0.4 0.3 0.1 -1.5 0.1 -0.2
Systolic Blood Pressure 0.2 1.2 2.8 -1.3 -0.6 -1.1 1.7 0.7 0.8 -1.6 0.4
Smoking Status 0.1 0.2 0.8 -0.4 -0.3 -0.2 -0.9 0.7 0.3 -0.1 -0.0
Allergy or Eczema 0.1 0.3 0.5 0.7 0.7 0.6 -0.1 -0.0 -0.5 0.4 -0.5
Cardiovascular Disease 0.5 1.8 5.6 1.1 0.6 0.8 0.9 2.4 -1.6 -0.6 -1.6
Hypothyroidism (self reported) 0.3 0.6 4.4 -0.4 -2.1 -0.2 -0.3 -0.3 -0.1 -0.2 0.3
Respiratory disease 1.4 3.1 4.5 2.1 -1.0 2.0 -1.4 1.8 -1.8 1.8 -1.8
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.7 -0.7 0.7 -0.4 -0.1 -0.3 1.3 -0.8 1.0
Lung FEV1/FVC ratio 0.7 3.7 10.4 -1.8 -0.3 -2.0 0.6 -3.2 1.3 -0.5 3.1
Lung FVC 0.1 0.5 0.9 -0.2 -1.0 -0.2 0.4 0.9 0.9 -0.6 -0.8
Neuroticism 0.4 0.9 2.7 -0.5 -1.5 -0.5 1.7 -0.1 1.0 -0.8 -0.6
Chronotype (morning person) 0.7 1.7 4.1 1.7 -0.3 1.8 1.3 -0.5 -2.0 0.4 -1.1
Hair Pigment 0.0 0.8 1.6 1.0 -0.7 0.9 -1.0 0.7 0.0 0.8 -1.3
Tanning 0.1 1.2 5.4 -0.8 -2.3 -0.5 0.6 0.6 1.0 -0.3 -1.3
Hand grip strength (left) 1.1 3.0 4.4 -1.9 1.1 -2.1 -0.7 -1.2 2.1 -2.1 2.0
Number of treatments/medications taken 3.5 6.3 12.2 2.9 0.6 3.3 -0.3 3.5 -2.2 1.8 -3.2
Average weekly spirits intake 1.6 2.0 6.0 -1.5 -0.7 -1.3 -0.9 -0.7 1.9 -2.5 0.6
Sensitivity / hurt feelings 0.3 0.5 2.0 0.5 -0.1 0.5 1.0 0.3 0.5 0.1 -1.4
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.6 -0.5 0.2 -0.7 -0.6 -0.5 0.6 -1.3 0.7
Hearing difficulty/problems: Yes 0.1 0.2 1.0 0.5 0.1 0.1 -0.2 -0.1 -1.0 -0.1 -0.7
Relative age of first facial hair 0.2 0.4 1.0 0.9 -0.8 0.6 1.0 0.4 -0.3 0.4 -0.5
Other serious medical condition/disability diagnosed by doctor 1.8 2.4 4.5 2.0 0.8 1.9 1.1 1.3 -2.1 1.6 -1.1
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.0 0.8 1.1 1.0 0.6 1.1 -0.3 -0.0 -1.7
Ever had hysterectomy (womb removed) 0.8 0.8 3.0 0.6 0.6 0.5 1.4 1.7 0.4 0.6 -0.6
Systolic blood pressure, automated reading 0.2 0.7 1.7 -0.7 -1.2 -0.3 1.0 0.7 0.3 -1.3 -0.2
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.9 0.1 -0.7 0.3 -1.4 0.0 0.2 -0.4 -0.3
Angina 2.3 3.1 7.5 1.6 -0.8 1.9 1.3 2.7 -1.5 1.0 -2.3
Medication for hormone replacement therapy 1.3 1.5 4.2 -1.3 0.3 -0.9 2.0 -0.9 2.0 -0.5 0.3
Vitamin and mineral supplements 0.6 0.8 1.6 0.4 -1.2 0.7 0.9 0.6 -0.7 1.3 -0.9
Supplements: Zinc 1.0 1.0 6.1 -0.6 2.5 -0.4 -0.3 0.5 0.7 -0.8 0.2
Medication: Co-codamol 0.1 0.1 0.5 -0.2 -0.4 -0.1 -0.4 0.2 0.7 -0.1 0.2
Medication: Metformin 2.3 3.3 7.3 2.4 -0.6 2.7 -0.4 0.6 -2.0 1.6 -2.4
Diabetes (father) 0.1 0.1 0.4 0.1 -0.0 0.1 -0.0 -0.1 0.6 0.4 0.1
Diabetes (mother) 0.4 0.5 2.2 0.1 0.1 -0.2 -1.0 -1.5 -0.1 0.9 0.6
Severe depression (siblings) 0.6 0.7 1.8 -0.4 -1.3 -0.5 -1.3 -0.3 0.2 0.1 1.3
Pack years adult smoking proportion 0.5 0.7 2.7 0.4 -0.1 0.6 -1.6 1.1 -0.8 0.2 -0.7
Impedance of leg (right) 0.1 0.7 2.7 0.4 1.6 0.1 0.4 0.4 -1.4 -0.6 -0.1
Leg fat-free mass (left) 0.3 1.6 2.6 -1.6 -0.2 -1.3 -1.3 -1.2 1.6 -1.1 1.4
Trunk fat percentage 0.1 0.5 1.7 0.1 -1.1 0.5 -1.3 0.2 -1.0 -0.2 -0.4
Hand grip strength (right) 1.1 3.0 5.7 -1.9 0.9 -2.0 -0.3 -1.7 1.8 -2.0 2.4
Townsend deprivation index at recruitment 0.5 0.7 1.8 -0.7 -0.1 -0.5 -1.4 0.8 0.8 -0.7 -0.9
Current tobacco smoking 2.4 3.9 7.0 -2.5 -1.6 -2.1 -1.2 -1.7 2.6 -2.0 1.8
Average weekly fortified wine intake 0.4 0.5 3.8 0.3 0.0 0.1 -2.0 0.2 -0.1 -0.2 -0.3
Maternal smoking around birth 1.8 2.7 8.0 0.8 -2.8 1.6 -0.8 1.8 0.3 1.8 -1.7
Fed-up feelings 0.1 0.3 0.8 -0.5 0.2 -0.6 0.3 -0.6 0.5 -0.2 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.4 -0.4 -0.3 -0.2 -0.0 0.2 0.6 -0.4 -0.2
Relative age voice broke 1.6 2.4 3.8 1.9 -0.7 1.6 1.2 1.9 -1.6 1.8 -1.3
Taking other prescription medications 4.4 6.7 15.4 3.2 1.7 2.9 -0.8 3.9 -3.0 1.4 -2.3
Age when periods started (menarche) 0.2 0.4 1.4 0.7 -0.5 0.5 -0.3 0.5 -0.6 1.2 -0.2
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.3 0.2 -0.9 0.7 1.4 1.4 0.5 -0.1 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.0 1.0 -0.7 1.0 -0.1 -0.3 -0.7 0.8 -0.1
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 5.5 -0.1 -0.2 -0.6 -2.3 -0.0 0.3 -0.7 0.2
Qualifications: CSEs or equivalent 0.5 0.7 3.6 -0.3 -0.8 0.1 0.3 -1.9 0.6 0.5 0.6
Serious illness, injury or assault to yourself 1.1 1.4 3.3 1.0 -0.1 1.1 -1.2 1.8 -1.3 1.4 -0.6
High blood pressure 0.6 1.7 3.9 1.2 -0.4 1.3 0.2 2.0 -1.9 0.4 -1.7
Hayfever, allergic rhinitis or eczema 0.5 1.1 1.9 1.4 1.3 1.3 0.4 -0.0 -1.1 1.1 -0.7
Multivitamins +/- minerals 0.6 0.7 1.5 -0.4 0.8 -0.8 -0.7 -0.8 0.5 -1.0 1.2
Stomach or abdominal pain in last month 0.4 0.5 1.2 -0.7 1.0 -0.6 0.3 1.1 1.0 -0.4 0.3
Supplements: Glucosamine 0.4 0.5 2.4 -0.3 -1.1 -0.1 -0.1 1.6 0.2 -0.5 -0.5
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.4 -0.5 -1.2 -0.5 1.1 -0.4 0.2 -0.2 0.4
Medication: Atenolol 0.4 0.6 2.2 0.6 0.5 0.9 1.5 0.4 -0.4 0.1 -0.8
Medication: Levothyroxine sodium 1.7 2.8 15.6 -1.7 -4.0 -1.4 -0.1 -0.0 1.0 -1.0 0.7
Sitting height 0.6 4.4 11.2 -1.7 2.3 -1.8 -3.4 -0.7 1.4 -2.7 1.7
Chronic bronchitis/emphysema (father) 0.7 0.9 2.0 0.9 0.5 1.0 -0.5 1.3 -1.4 0.9 -0.4
High blood pressure (mother) 0.3 0.4 1.6 0.2 0.7 -0.3 -0.2 -1.3 -0.3 -0.7 0.8
Body mass index (BMI) 0.2 0.9 5.3 -0.5 -2.3 0.1 -1.1 -0.6 0.4 0.2 -0.1
Impedance of leg (left) 0.3 1.5 5.1 1.3 1.4 0.9 0.5 1.3 -2.3 0.3 -0.8
Leg predicted mass (left) 0.3 1.7 2.7 -1.6 -0.3 -1.4 -1.2 -1.2 1.6 -1.1 1.4
Trunk fat mass 0.1 0.5 2.6 -0.4 -1.0 0.0 -1.6 -0.1 -0.3 -0.6 0.1
Waist circumference 0.1 0.5 2.5 -0.2 -1.6 0.4 -1.0 -0.1 -0.3 0.2 -0.6
Number of incorrect matches in round 0.6 0.9 4.0 0.3 -0.9 0.6 0.7 -0.1 -0.8 1.0 -2.0
Past tobacco smoking 0.1 0.1 0.5 0.1 -0.3 0.3 -0.7 -0.3 0.4 0.4 0.3
Alcohol usually taken with meals 0.6 1.0 4.7 -0.5 0.1 -0.6 2.2 -1.4 0.5 -0.2 0.3
Nervous feelings 0.2 0.4 1.3 0.2 -0.7 0.4 1.1 -0.4 -0.1 -0.2 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.5 -0.4 -0.2 -0.5 -1.2 0.1 0.3 -0.6 0.3
Hearing difficulty/problems with background noise 0.4 0.6 2.3 0.5 1.5 0.3 -0.1 0.8 -1.0 -0.5 -0.8
Hair/balding pattern: Pattern 2 0.5 0.7 4.0 0.3 2.0 -0.0 0.4 -1.0 -0.4 -0.3 0.2
Had menopause 1.1 1.4 4.2 1.4 0.7 1.2 0.5 0.8 -2.0 1.1 -0.8
Had other major operations 0.8 1.0 2.7 -1.2 -0.4 -1.0 -1.6 -0.1 1.3 -1.0 0.1
Forced vital capacity (FVC) 0.1 0.4 1.0 -0.1 1.0 -0.2 -0.9 0.7 0.5 -0.6 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.3 0.9 1.0 0.0 0.8 -0.6 -0.1 -0.6 0.6 -0.1
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 3.7 -0.9 1.6 -1.1 0.1 -0.8 0.4 -1.9 1.1
Qualifications: None of the above 0.3 0.7 2.5 -0.0 -1.6 0.1 0.5 1.3 -0.4 -0.7 -0.9
Financial difficulties in last 2 years 0.0 0.1 0.2 -0.1 0.0 -0.2 0.4 -0.0 0.4 -0.0 -0.2
Mouth/teeth dental problems 0.6 0.9 1.8 -1.3 0.2 -1.2 -0.5 -1.3 1.0 -0.8 1.0
Heart attack 1.0 1.2 2.6 1.3 -0.1 1.5 0.2 1.3 -1.6 1.0 -0.8
Allergy 0.2 0.5 1.2 -1.1 -0.1 -1.0 0.3 -0.3 1.0 -0.8 0.4
Pain all over the body in last month 0.6 0.6 3.4 -0.1 1.8 0.0 0.2 -0.2 -0.5 1.1 0.5
Diabetes (self-reported) 0.3 0.5 1.4 0.8 0.6 1.2 0.3 0.7 -0.5 0.6 -0.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 2.2 -0.1 -0.3 -0.5 -1.5 -0.5 0.3 -0.6 0.6
Medication: Ramipril 0.9 1.2 4.2 0.7 0.4 1.1 2.0 0.9 -1.1 0.5 -1.2
Medication: Simvastatin 1.6 2.4 5.3 1.7 0.6 1.9 1.1 2.3 -1.0 0.9 -2.0
Fluid intelligence score 0.2 0.5 1.5 0.1 0.6 -0.4 -0.3 -1.1 -0.6 0.3 1.2
Illnesses of siblings 0.4 0.5 2.9 0.2 1.7 -0.3 0.8 0.2 -0.2 -0.6 -0.3
Neuroticism score 0.4 0.8 2.2 -0.7 -1.0 -0.6 1.5 -0.4 1.4 -0.5 0.0
Weight 0.2 0.9 2.4 -1.2 -0.6 -0.7 -1.6 -0.7 0.7 -1.1 0.7
Impedance of arm (right) 0.4 1.8 4.6 1.7 1.7 1.3 -0.2 1.2 -2.1 0.8 -0.8
Arm fat percentage (right) 0.2 0.9 3.6 0.2 -1.9 0.7 -1.6 -0.2 -0.5 0.5 -0.5
Trunk fat-free mass 0.3 1.9 3.6 -1.9 0.2 -1.6 -1.2 -0.8 1.8 -1.6 1.2
Hip circumference 0.1 0.6 2.5 -0.7 -1.6 -0.0 -1.1 -0.3 0.5 -0.2 -0.1
Time employed in main current job 0.8 1.0 3.2 0.7 -0.4 1.3 -0.3 1.0 -0.3 1.0 -1.8
Alcohol intake versus 10 years previously 1.8 2.7 5.2 -2.3 -1.2 -2.1 -0.0 -1.6 1.8 -1.5 1.7
Father’s age at death 0.3 0.4 2.0 0.4 -1.4 0.5 0.3 -0.3 -0.2 0.7 -0.2
Worrier / anxious feelings 1.2 2.3 9.4 -1.2 -3.1 -1.0 1.4 -1.8 1.2 -0.6 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 4.0 -0.0 1.4 -0.2 2.0 0.2 -0.2 0.1 1.1
Falls in the last year 0.6 0.8 2.8 -0.3 1.5 -0.3 -1.7 -1.0 0.2 -0.2 0.2
Hair/balding pattern: Pattern 3 0.5 0.7 1.7 -1.2 -1.3 -1.0 -0.2 -0.6 0.8 0.2 0.5
Number of live births 0.3 0.5 2.1 0.1 0.1 0.2 -1.4 1.1 -0.7 0.0 -0.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.0 -0.7 0.7 -0.9 -0.5 -0.4 0.9 -0.7 1.0
Pulse rate 0.6 1.1 4.4 -0.5 1.6 -0.5 -2.1 -0.3 0.3 -0.8 0.2
Happiness 0.6 0.8 1.8 -0.9 -0.9 -0.9 0.0 -0.5 0.9 -1.0 1.3
Noisy workplace 0.8 1.0 4.3 -0.3 0.3 0.0 -1.8 -0.1 0.3 -2.1 -0.2
Qualifications: A levels/AS levels or equivalent 0.3 0.7 5.1 0.6 2.3 0.2 0.1 0.1 -0.1 0.3 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.6 1.3 -0.7 1.3 0.3 0.8 -0.9 0.6 -1.0
Mouth/teeth dental problems: Dentures 1.4 2.4 7.4 1.6 -0.2 1.9 -0.2 2.7 -1.8 0.8 -1.1
Asthma 0.3 0.6 1.5 0.6 -1.0 0.6 -1.2 0.8 -0.6 0.1 -0.5
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.0 4.7 -2.0 -0.8 -1.9 -2.2 -1.8 1.9 -1.6 1.3
Medication: Cholesterol lowering 0.2 0.3 2.0 0.0 -0.0 -0.0 1.4 0.5 0.1 -0.6 -0.1
Depression (self-reported) 0.3 0.4 1.9 -0.1 -0.5 -0.2 -0.5 0.7 0.3 -0.6 -1.4
Medication: Lansoprazole 4.2 4.8 9.4 2.8 0.9 2.8 -0.6 2.6 -3.1 1.3 -1.9
Prospective memory result 1.3 1.6 4.4 -1.7 -1.3 -1.1 0.2 -0.3 2.1 -1.3 0.6
Lung cancer (father) 0.5 0.6 1.7 0.2 0.3 0.2 -0.7 1.2 -0.0 -0.8 -1.3
Illnesses of mother 0.5 0.6 1.4 -0.9 -1.2 -0.7 1.1 0.0 0.7 -0.7 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 2.7 -1.3 0.4 -1.6 -0.7 -0.6 1.6 -1.3 1.6
Pulse wave Arterial Stiffness index 1.6 1.9 5.7 -1.1 1.2 -0.8 2.4 -2.0 0.7 -1.4 -0.0
Impedance of arm (left) 0.2 0.9 3.9 0.8 2.0 0.5 -0.1 1.0 -1.2 -0.2 -0.3
Arm fat mass (right) 0.1 0.5 2.2 -0.2 -1.4 0.4 -1.5 -0.0 -0.1 0.2 -0.2
Trunk predicted mass 0.3 1.9 3.5 -1.9 0.3 -1.6 -1.1 -0.8 1.8 -1.6 1.3
Standing height 0.4 3.7 10.6 -1.4 3.3 -1.7 -1.6 -0.3 0.7 -2.7 1.8
Length of working week for main job 1.8 2.0 5.0 -1.8 -1.5 -1.5 1.2 -1.0 2.2 -0.7 0.6
Exposure to tobacco smoke at home 0.2 0.2 0.5 0.3 -0.7 0.2 -0.5 0.7 0.0 0.5 0.2
Breastfed as a baby 0.3 0.3 1.6 -0.4 0.1 -0.4 0.5 -1.2 0.4 -0.4 0.4
Tense / ‘highly strung’ 0.3 0.5 1.5 0.3 0.0 0.4 1.2 0.5 0.1 0.9 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.7 -0.3 -0.0 -0.2 -0.6 0.5 0.0 -0.4 -0.9
Hair/balding pattern: Pattern 4 1.6 3.8 8.2 2.8 0.9 2.9 -0.5 1.1 -1.7 2.2 -2.0
Birth weight of first child 0.1 0.3 0.9 -0.5 0.3 0.2 -0.4 0.3 -0.1 0.9 -0.9
Peak expiratory flow (PEF) 0.1 0.3 1.3 -0.3 -0.5 -0.4 -0.4 -1.1 0.5 -0.5 0.3
Pulse wave reflection index 1.6 2.0 5.9 -1.6 -0.8 -1.1 2.4 -1.8 1.2 -0.9 0.7
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.9 0.3 -0.4 0.0 -0.5 1.0 -0.3 -0.9 -0.5
Loud music exposure frequency 0.5 0.5 1.6 0.6 0.6 0.7 -1.3 0.3 -0.9 0.6 -0.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.2 -0.1 1.1 -0.2 -0.4 -0.2 0.0 0.9 0.3
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.7 0.4 0.9 -0.1 0.3 0.4 -0.1 0.2 -0.0
Blood clot in the leg (DVT) 1.6 2.0 3.3 -1.8 -1.5 -1.7 0.3 -1.0 1.7 -1.0 1.8
Medication: Paracetamol 0.7 1.1 3.3 0.9 0.7 1.0 -1.2 1.0 0.1 0.6 -1.8
Headache pain in last month 0.1 0.1 0.6 0.3 -0.2 0.2 0.1 0.0 -0.0 0.8 -0.7
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 3.5 -0.5 0.2 -0.3 -1.9 -1.2 0.4 0.7 0.7
Glaucoma (self-reported) 1.8 2.1 5.4 1.8 1.5 1.8 0.3 0.7 -2.3 0.7 -1.2
Gout (self-reported) 1.8 2.5 4.8 1.6 -0.4 1.8 2.0 2.2 -0.7 0.8 -2.0
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 4.6 -0.9 -2.1 -0.9 -0.1 0.1 0.4 -0.9 0.7
Medication: Amlodipine 0.7 1.0 1.8 1.0 -0.1 1.3 1.3 0.7 -0.9 1.2 -1.0
Medication: Ventolin 100micrograms inhaler 0.6 0.7 3.5 0.4 -0.5 0.6 -1.9 -0.1 -0.7 1.1 0.2
Birth weight 1.3 2.8 5.6 1.4 -0.1 1.6 2.0 2.2 -0.9 1.7 -2.4
Chronic bronchitis/emphysema (mother) 1.3 1.5 3.4 1.2 -0.3 1.7 0.3 1.9 -0.9 0.6 -1.8
High blood pressure (siblings) 0.3 0.4 1.3 0.1 -0.7 0.1 -1.1 -0.8 0.0 0.7 0.6
Forced vital capacity (FVC), Best measure 0.3 1.3 2.5 -1.1 1.0 -1.3 -0.8 0.2 1.4 -1.6 1.1
Body fat percentage 0.2 0.6 2.2 0.1 -1.5 0.5 -1.3 0.1 -0.8 0.0 -0.4
Leg fat percentage (right) 0.1 0.5 2.7 -0.2 -1.6 0.1 -1.0 -0.2 -0.5 -0.5 -0.2
Arm fat-free mass (right) 0.4 1.9 3.5 -1.9 0.1 -1.6 -0.9 -1.1 1.7 -1.5 1.4
Exposure to tobacco smoke outside home 1.8 2.4 6.7 -1.2 -2.6 -1.1 -1.1 -1.1 1.2 -0.5 2.3
Comparative body size at age 10 0.1 0.3 1.3 -0.5 -1.1 0.2 -0.6 -0.5 0.6 -0.3 0.1
Number of full brothers 0.5 0.7 1.9 0.6 -0.5 1.2 -0.4 0.4 -0.5 1.4 -0.9
Worry too long after embarrassment 0.6 1.1 6.8 0.7 0.0 0.7 2.6 0.4 0.0 0.4 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.0 0.3 1.1 0.1 -1.4 -0.4 -0.0 -0.2 -0.8
Wheeze or whistling in the chest in last year 0.8 1.4 3.8 1.3 -0.2 1.3 -0.6 1.2 -1.4 1.9 -0.7
Number of children fathered 0.3 0.4 1.0 0.3 0.1 0.2 -0.6 1.0 -0.6 -1.0 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 5.9 -0.2 0.5 -0.3 2.4 0.3 -0.2 -1.0 -0.3
Age at first live birth 0.4 0.8 2.2 0.4 1.5 -0.0 1.0 -0.5 -1.3 -0.3 0.9
Pulse wave peak to peak time 1.5 1.8 6.1 1.0 -1.1 0.6 -2.5 1.9 -0.7 1.1 0.1
Health satisfaction 0.1 0.1 0.3 0.2 -0.1 0.2 -0.6 -0.1 0.0 0.3 0.2
Shortness of breath walking on level ground 3.0 3.6 6.0 2.2 0.6 2.4 -0.7 2.4 -2.0 1.7 -2.2
Qualifications: College or University degree 0.9 2.8 13.4 1.4 3.7 0.9 0.2 1.8 -1.0 1.3 -0.5
Eye problems/disorders: None of the above 0.7 0.8 2.7 -0.6 -1.6 -0.7 -0.5 0.6 1.0 0.9 0.7
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.2 0.6 -0.6 0.6 1.1 0.2 0.0 -0.2 -1.0
Emphysema/chronic bronchitis 4.1 4.6 9.5 2.8 0.4 2.7 -0.1 1.5 -2.7 3.1 -1.6
Medication for pain relief, constipation, heartburn 1.6 2.8 8.5 -1.3 -0.8 -1.8 1.4 -2.3 0.6 -0.3 2.9
Neck or shoulder pain in last month 0.4 0.5 2.5 0.1 -1.6 -0.1 0.2 -0.1 0.8 -0.8 -0.7
Medication: Blood pressure 0.4 0.7 1.6 0.3 -1.3 0.7 1.2 0.9 -0.5 0.1 -1.1
Angina (self-reported) 3.4 4.4 9.5 2.2 -0.7 2.5 0.9 3.1 -2.0 1.4 -2.8
Migraine (self-reported) 0.3 0.3 1.2 0.7 0.3 0.3 -0.6 0.3 -0.5 1.1 -0.1
Medication: Ibuprofen 2.6 3.1 5.1 -2.2 -0.9 -2.3 -0.9 -1.4 2.1 -1.9 1.8
Medication: Allopurinol 1.4 1.9 5.4 1.3 -0.0 1.4 2.3 1.9 -0.5 1.0 -1.2
Medication: Omeprazole 0.7 0.9 4.6 -0.8 -2.2 -0.2 -0.5 0.6 0.6 -0.5 -0.5
Medication: Seretide 50 evohaler 0.1 0.1 0.6 0.2 0.2 0.3 0.8 0.2 0.2 0.4 -0.3
Mean time to correctly identify matches 0.2 0.3 1.1 0.1 -0.3 -0.1 0.6 0.3 -0.7 -1.0 -0.8
Heart disease (mother) 0.7 0.8 2.3 -0.5 -0.1 -0.7 -1.2 -1.3 0.3 -1.5 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.7 1.0 0.1 1.3 0.6 1.0 -0.4 0.3 -0.8
Whole body fat mass 0.1 0.5 2.0 -0.3 -1.2 0.2 -1.4 0.0 -0.3 -0.4 -0.1
Leg fat mass (right) 0.1 0.5 1.9 -0.6 -1.4 -0.1 -1.1 -0.2 0.1 -0.4 0.1
Arm predicted mass (right) 0.3 1.7 3.3 -1.8 0.2 -1.5 -0.8 -0.8 1.6 -1.3 1.4
Pulse rate, automated reading 0.3 0.8 3.6 0.5 -0.0 0.6 -1.9 1.0 -0.6 0.9 -0.3
Alcohol intake frequency. 0.2 0.5 1.3 0.7 -0.3 1.0 -0.2 -0.1 0.2 1.1 -1.0
Comparative height size at age 10 0.2 1.0 5.0 -0.2 2.2 -0.0 -0.8 0.6 0.3 -1.4 0.5
Number of full sisters 0.4 0.5 1.6 -0.7 -0.5 -0.7 -0.7 -1.3 0.5 -0.4 0.7
Suffer from ‘nerves’ 0.3 0.5 1.5 0.6 0.0 0.3 1.2 0.3 -0.5 -0.6 -1.1
Overall health rating 0.7 1.5 3.3 1.4 0.0 1.8 0.0 1.6 -0.8 1.2 -1.6
Chest pain or discomfort 2.0 2.8 4.8 2.1 1.0 2.2 -0.7 1.6 -1.3 1.8 -2.1
Had major operations 1.0 1.2 2.1 1.2 -0.6 0.9 1.5 0.8 -1.3 1.4 -0.9
Age at last live birth 0.3 0.5 2.4 0.6 1.6 0.1 -0.2 -0.0 -0.9 -0.1 0.2
Family relationship satisfaction 0.3 0.4 1.0 0.6 0.3 0.3 -0.9 -0.2 -0.9 0.5 1.0
Leg pain on walking 0.8 1.0 2.9 -0.9 0.4 -0.9 0.8 -0.8 1.7 -1.3 0.9
Qualifications: NVQ or HND or HNC or equivalent 2.1 2.6 6.3 -1.8 -0.5 -1.6 -1.0 -1.5 2.5 -2.2 0.4
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.8 -0.0 0.3 0.4 0.2 -0.9 0.6 0.6 0.8
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 3.2 -0.3 1.8 -0.5 0.5 0.3 -0.0 -0.5 -0.6
Medication: Aspirin 4.1 5.4 14.8 2.2 1.4 2.5 0.2 3.8 -2.2 0.4 -3.2
Supplements: Vitamin C 0.7 0.9 2.0 -0.7 1.2 -0.8 -0.5 0.3 1.1 -1.4 0.8
Knee pain experienced in last month 0.3 0.5 1.9 0.0 -1.4 0.2 1.1 -0.6 -0.0 0.1 -0.6
Hypertension (Self-reported) 0.6 1.5 3.2 1.1 -0.4 1.2 0.3 1.8 -1.8 0.3 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.6 3.0 4.0 1.9 -1.8 2.0 -1.5 1.5 -1.7 1.6 -1.9
Illnesses of father: Heart disease 1.9 2.6 4.8 2.2 1.7 1.9 1.9 1.0 -1.6 0.4 -1.6
Illnesses of siblings: Diabetes 1.0 1.2 4.5 1.0 -0.1 1.5 -0.7 -0.1 -0.6 2.1 -0.8
Smoking status: Previous 1.4 2.0 4.0 1.6 0.6 1.5 0.6 1.4 -2.0 0.9 -2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 2.9 -1.4 0.6 -1.1 -1.4 -0.9 1.3 -1.2 1.7
Whole body fat-free mass 0.3 1.5 2.9 -1.7 0.1 -1.4 -1.1 -0.8 1.6 -1.2 1.2
Leg fat-free mass (right) 0.2 0.9 1.3 -1.1 -0.3 -0.9 -1.1 -0.8 1.1 -0.5 1.1
Arm fat percentage (left) 0.2 0.6 2.9 -0.2 -1.7 0.3 -1.4 -0.4 -0.0 0.1 -0.2
Average weekly red wine intake 1.2 1.7 4.0 -0.6 -0.6 -1.3 1.4 -1.9 1.0 -2.0 0.7
Handedness (chirality/laterality): Left-handed 1.4 1.6 3.6 -1.7 1.2 -1.3 -0.5 -0.9 1.3 -1.9 0.6
Mood swings 1.8 3.3 4.7 -2.1 -1.7 -2.0 1.2 -2.2 2.1 -1.1 1.8
Loneliness, isolation 0.7 1.0 1.8 -0.9 -1.1 -1.1 -0.2 -1.4 1.0 -0.8 1.1
Long-standing illness, disability or infirmity 2.6 4.0 7.1 2.3 -0.8 2.7 -0.2 2.2 -1.9 2.3 -2.3
Ever had bowel cancer screening 0.5 0.6 1.4 0.9 0.1 1.0 0.6 0.6 -1.2 0.3 -0.7
Diabetes diagnosed by doctor 0.4 0.6 1.8 1.0 0.2 1.3 0.2 0.7 -0.6 0.9 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 0.7 -0.8 0.7 0.5 0.1 -0.4 0.4 -0.4
Friendships satisfaction 0.3 0.4 1.8 -0.0 0.3 -0.3 -1.1 0.1 -0.1 -1.4 0.3
Qualifications: nursing, teaching 0.2 0.3 1.0 1.0 0.7 0.7 -0.1 -0.2 -0.6 0.5 0.1
Commuting to job workplace: Walk 1.3 1.4 3.6 -0.8 0.8 -1.2 1.9 -1.2 0.3 -1.7 0.3
Eye problems/disorders: Cataract 1.2 1.4 7.5 0.9 2.7 0.8 0.8 -0.0 -1.3 -0.2 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.3 0.7 -1.3 0.6 0.0 -0.2 -0.6 1.5 -0.8
Medication for cholesterol 3.2 4.9 11.1 -2.3 -0.3 -2.9 -1.9 -2.3 1.7 -1.6 3.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 4.7 0.8 0.3 1.1 -0.4 2.2 -1.1 0.5 -2.0
Back pain experienced in last month 0.7 1.1 3.3 -0.9 -1.8 -0.6 0.3 0.7 1.8 -0.5 -0.4
Mineral and other dietary supplements 0.2 0.3 0.7 0.3 -0.6 0.4 -0.7 0.2 -0.1 0.8 -0.5
Breast cancer (self-reported) 0.7 0.8 2.6 -0.8 -0.7 -1.2 -0.1 -1.6 0.9 -0.5 0.7
Asthma (self-reported) 0.5 0.9 2.1 1.0 -0.7 1.0 -1.4 0.9 -1.1 0.7 -0.6
Osteoporosis (self-reported) 0.5 0.7 2.2 -0.7 -0.4 -0.9 1.1 -0.6 0.1 -0.4 1.5
Osteoarthritis (self-reported) 1.5 2.0 4.6 -1.3 -2.2 -1.5 -0.4 -1.0 1.0 -2.0 1.1
Medication: Aspirin 4.2 5.5 14.2 2.4 1.3 2.7 -0.1 3.8 -2.4 0.7 -3.0
Medication: Gliclazide 0.9 1.0 2.5 1.5 -0.4 1.6 -0.3 -0.6 -0.8 1.3 -0.8
Illnesses of father: None of the above (group 1) 1.2 1.5 3.3 -1.4 -1.3 -1.8 -1.2 -1.0 0.4 -1.1 1.2
Smoking status: Current 2.7 4.3 7.4 -2.7 -1.2 -2.4 -0.8 -1.9 2.7 -1.9 2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.0 -0.7 -0.0 -1.0 -0.9 -0.6 0.7 -0.8 0.9
Whole body water mass 0.3 1.4 2.7 -1.6 -0.0 -1.4 -1.1 -0.8 1.6 -1.1 1.2
Leg predicted mass (right) 0.2 0.8 1.5 -1.1 -0.4 -0.9 -1.0 -0.7 1.2 -0.5 1.0
Arm fat mass (left) 0.2 0.6 2.6 -0.5 -1.4 0.1 -1.6 -0.4 0.1 -0.1 -0.1
Number of self-reported non-cancer illnesses 1.9 3.2 4.9 2.2 -0.9 2.2 -0.2 2.2 -2.0 1.4 -2.1
Average weekly champagne plus white wine intake 0.2 0.3 1.4 0.2 1.2 -0.0 0.3 0.3 0.6 0.2 -0.4
Miserableness 1.7 2.9 6.8 -2.1 -1.3 -1.9 -0.5 -1.5 2.6 -1.6 1.1
Guilty feelings 1.9 2.9 7.5 -2.0 -1.5 -1.7 0.4 -2.2 2.7 -0.9 0.9
Wears glasses or contact lenses 0.9 1.1 1.9 1.2 -0.1 1.4 -0.1 0.5 -1.4 1.2 -1.2
Ever taken oral contraceptive pill 2.2 2.4 4.0 1.5 0.6 1.6 -2.0 1.4 -1.8 2.0 -1.1
Hearing aid user 0.7 0.8 3.2 1.0 1.8 1.0 0.2 0.3 -1.0 0.3 -0.3
Mother’s age at death 0.7 0.9 2.3 -0.2 -1.5 -0.5 1.5 -0.9 0.9 0.7 0.4
Financial situation satisfaction 1.1 1.4 3.1 -1.4 -0.0 -1.3 0.4 -0.1 1.8 -1.7 1.1
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.2 0.8 1.1 0.7 -0.2 0.6 -0.3 -0.6 -0.3
Commuting to job workplace: Public transport 1.1 1.4 2.4 1.4 0.9 1.0 1.3 1.3 -1.6 0.2 -1.1
Eye problems/disorders: Glaucoma 0.2 0.3 0.7 0.2 0.4 0.6 -0.9 -0.2 -0.6 -0.3 -0.5
Medication: Blood pressure 2.5 4.7 8.7 2.3 -0.8 2.6 1.3 2.6 -2.5 1.3 -3.0
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.5 0.8 1.2 1.2 -0.0 -0.0 -0.4 0.6 -0.8
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.9 -0.5 0.9 -0.6 -0.0 -0.6 -0.3 -0.9 0.7
High cholesterol (Self-reported) 2.4 4.3 9.2 2.4 1.5 2.3 1.7 3.0 -2.0 0.9 -2.1
Medication: Bendroflumethiazide 0.5 0.7 4.6 -0.7 -2.1 -0.2 -0.2 0.1 0.2 -0.6 -0.3
Medication: Paracetamol 0.7 1.1 2.6 1.1 1.2 1.1 -0.5 1.3 -0.3 0.9 -1.6
Medication: Lisinopril 1.1 1.4 2.1 1.4 -0.3 1.4 1.2 0.7 -1.4 1.2 -1.4
Medication: Atorvastatin 0.1 0.2 0.5 0.1 0.5 0.4 -0.7 -0.1 -0.5 -0.4 -0.1
Illnesses of father: High blood pressure 0.4 0.5 1.4 -0.5 0.1 -0.1 -0.5 -1.0 1.1 0.2 1.2
Alcohol drinker status: Never 0.4 0.5 1.3 -0.1 -0.6 -0.1 -1.1 0.6 0.6 0.7 -1.1
Ever smoked 0.5 0.9 2.1 -1.3 0.2 -1.4 0.8 -0.2 1.1 -1.3 0.4
Basal metabolic rate 0.3 1.6 2.8 -1.7 -0.2 -1.4 -1.3 -0.9 1.6 -1.2 1.2
Leg fat percentage (left) 0.2 0.8 3.9 0.2 -2.0 0.6 -1.0 0.1 -0.9 0.1 -0.7
Arm fat-free mass (left) 0.2 0.8 1.6 -1.3 -0.1 -1.0 -0.9 -0.6 1.1 -0.8 0.8
Number of operations (self-reported) 0.6 0.9 2.6 0.8 -0.8 0.6 1.5 0.7 -0.7 0.1 -1.6
Average weekly beer plus cider intake 0.2 0.2 0.5 -0.7 -0.4 0.0 0.2 0.6 0.7 -0.4 -0.5
Irritability 0.7 1.1 6.0 0.1 -1.2 0.2 2.4 -0.4 0.8 0.0 -0.9
Risk taking 0.2 0.3 0.7 -0.4 -0.5 -0.7 -0.8 -0.8 -0.2 -0.1 0.5
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.1 0.3 -0.7 0.3 -0.2 0.9 -0.2 -1.0 -1.0
Fractured/broken bones in last 5 years 0.6 0.8 2.2 0.1 -0.9 0.3 -1.5 1.3 -0.5 -0.1 -1.2
Age started oral contraceptive pill 0.6 0.7 1.6 0.5 1.2 0.4 0.8 0.1 -1.1 0.6 -1.2
Diastolic blood pressure, automated reading 1.4 4.4 9.2 -3.0 -1.6 -2.6 -1.6 -1.5 2.0 -2.0 1.9
Ever depressed for a whole week 0.6 0.7 1.5 -0.3 0.9 -0.1 1.2 1.0 0.9 -0.7 -0.9
Unable to work because of sickness or disability 0.8 1.1 4.5 -0.7 1.4 -0.2 -2.1 -0.3 0.7 -0.9 0.5
Commuting to job workplace: Cycle 1.5 1.8 4.7 1.6 -0.5 1.4 0.3 1.3 -0.8 1.5 -2.2
Myopia 0.4 0.6 2.0 -0.1 -0.1 0.5 -1.4 0.1 0.6 1.4 -0.4
Vascular/heart problems diagnosed by doctor 1.0 2.7 5.4 -1.5 0.7 -1.7 -0.6 -2.3 2.2 -0.4 2.3
Cholesterol lowering medication 10.1 14.8 27.1 4.7 1.5 5.2 0.0 4.7 -3.6 2.9 -4.9
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 6.2 -0.9 -2.5 -0.3 -0.9 0.3 0.7 -0.6 -0.2
Pain experienced in last month 0.8 1.3 3.8 1.5 0.6 1.3 0.2 1.3 -1.9 0.4 -0.6
Supplements: Calcium 0.5 0.5 1.0 -0.9 -0.2 -0.8 0.4 -0.5 0.8 -0.7 1.0
Basal cell carcinoma (self-reported) 0.6 0.7 1.4 0.8 1.1 0.7 -0.3 1.0 -0.8 -0.2 -1.2
Heart attack/myocardial infarction (self-reported) 1.2 1.5 3.2 1.5 -0.2 1.6 0.2 1.4 -1.8 1.2 -0.9
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 2.7 -1.6 -1.7 -1.4 0.6 -0.7 1.5 -0.6 1.3
Heart disease (siblings) 0.3 0.3 1.4 0.0 0.4 0.7 0.2 0.5 0.3 0.5 -1.2
Alcohol drinker status: Previous 1.1 1.3 3.9 0.8 -0.9 1.2 -0.5 1.6 -0.5 0.6 -2.0
Pack years of smoking 0.5 0.8 1.7 0.6 -0.5 0.7 -1.3 1.3 -0.9 0.4 -1.0
Impedance of whole body 0.2 1.1 3.7 1.0 1.9 0.6 -0.0 0.7 -1.8 -0.2 -0.3
Leg fat mass (left) 0.1 0.5 2.4 -0.3 -1.6 0.2 -1.1 -0.1 -0.1 -0.1 -0.2
Arm predicted mass (left) 0.1 0.7 1.5 -1.1 0.4 -0.8 -1.2 -0.5 0.9 -0.7 0.8