Hub : Genes

EVA1C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1600	0.0650	0.00930	0.008	NA	0.030	NA	0.017	8.5e-02	NA	4.3e-03	NA	2.4e-02
2	GTEx	Lung	0.1380	0.0503	0.00500	-0.003	NA	-0.003	NA	-0.004	7.7e-01	NA	7.7e-01	NA	8.6e-01
3	METSIM	Adipose	0.0619	0.0218	0.00044	0.046	0.028	0.041	0.029	0.037	1.8e-07	4.5e-05	8.1e-07	3.3e-05	2.4e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	0.8	-0.6	0.4	-0.9
Bipolar Disorder or Schizophrenia	0.9	2.3	6.6	0.3	2.6	-0.4
Depressed Affect (Nagel 2018)	1.0	2.0	6.0	-0.4	-2.4	0.0
Depression (Nagel 2018)	0.2	0.3	0.7	0.1	0.4	-0.8
Intelligence (Savage-Jansen 2018)	0.6	1.7	4.6	-0.4	-2.1	-0.6
Neuroticism (Nagel 2018)	1.6	3.7	8.2	-1.3	-2.9	-1.1
Schizophrenia (2018)	1.5	3.1	8.3	0.9	2.9	0.3
Schizophrenia vs Biploar Disorder	0.7	1.0	2.4	0.3	0.6	1.6
Worry (Nagel 2018)	1.9	3.9	7.0	-1.1	-2.7	-1.9
Alzheimer’s Disease (in mother)	0.5	0.6	0.9	0.4	-0.9	1.0
Alzheimer’s Disease (in father)	1.2	1.3	2.1	-1.4	-1.3	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.5	0.9	-0.8	-0.9	0.3
Crohns Disease (2017)	0.3	0.6	1.0	0.4	-1.0	-0.7
Irritable Bowel Disease (IBD)	0.2	0.6	1.6	0.1	-1.2	-0.4
Ulcerative Colitis (UC)	0.3	0.5	1.4	-0.1	-1.2	0.1
Major Depression (MDD)	1.3	1.6	4.3	-2.1	-0.7	0.3
Reaction Time	0.8	1.6	2.7	1.6	1.2	0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.3	-1.5	-1.5	0.3
Breast Cancer	0.1	0.1	0.4	-0.6	-0.2	-0.1
Ovarian Cancer	1.7	2.3	3.3	0.9	1.8	1.7
Prostate Cancer	0.3	0.4	1.1	1.1	0.0	0.2
Age at First Birth	1.5	2.2	3.8	-1.9	-1.4	-0.8
Bipolar Disorder (2011)	0.9	0.9	1.6	-1.3	-0.3	-0.9
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	0.2	0.5	0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.3	-0.6	0.4	0.2
Crohns Disease (2012)	0.2	0.3	0.8	-0.3	-0.9	-0.3
Mean Putamen Volume	0.5	0.6	1.6	-1.3	-0.1	0.2
Fasting Glucose	0.6	0.8	1.8	-1.3	-0.3	0.7
HbA1C	0.4	0.5	1.1	-1.1	0.4	-0.2
HDL Cholesterol	0.8	1.3	2.3	-0.3	-1.5	-1.2
LDL Cholesterol	0.2	0.4	0.6	-0.7	-0.2	-0.8
Lupus	0.7	1.0	2.2	0.8	-1.5	0.4
Neuroticism (2016)	0.6	0.9	1.9	-0.7	-1.4	0.5
Primary Biliary Cirrhosis	3.0	4.3	8.2	2.9	1.8	1.2
Rheumatoid Arthritis	1.3	1.8	4.7	-0.6	2.2	0.6
Schizophrenia (2014)	1.1	2.4	5.8	0.3	2.4	1.1
Triglycerides	0.1	0.1	0.4	0.1	-0.6	-0.0
Type 2 Diabetes (T2D) (2012)	1.2	1.3	3.5	0.3	1.9	0.6
Ulcerative Colitis	0.1	0.1	0.2	-0.3	0.0	0.5
Blood Eosinophil Count	0.4	2.9	5.2	2.3	0.1	-1.8
Blood Platelet Count	0.3	4.0	6.4	-2.5	-1.9	-1.4
Blood Red Count	0.1	0.9	1.7	-1.3	-0.1	-1.0
Blood White Count	0.2	1.5	3.3	-1.1	-0.2	-1.8
Heel T-Score	0.5	4.3	8.2	0.7	-2.1	2.9
BMI	0.2	0.9	1.6	0.8	-0.6	1.3
Height	0.6	11.5	27.2	-2.3	1.4	-5.2
Waist Hip Ratio (WHR)	0.6	2.6	4.0	-1.9	0.0	-2.0
Systolic Blood Pressure	2.0	9.9	15.1	-3.3	-1.9	-3.9
Smoking Status	0.3	0.6	1.4	-0.2	-0.7	1.2
Allergy or Eczema	1.2	3.1	4.7	-2.1	2.2	0.2
Cardiovascular Disease	0.6	2.0	3.2	-1.8	-1.4	-0.9
Hypothyroidism (self reported)	0.2	0.4	0.7	0.8	-0.2	-0.6
Respiratory disease	1.8	4.1	9.1	1.0	3.0	-1.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	0.9	0.9	0.9	0.9
Lung FEV1/FVC ratio	0.8	4.2	9.2	0.1	-1.9	3.0
Lung FVC	0.9	4.7	9.7	-1.0	-3.1	1.9
Neuroticism	1.2	3.0	7.6	-0.4	-2.8	-1.1
Chronotype (morning person)	0.2	0.6	1.4	1.2	0.5	-0.3
Hair Pigment	0.2	6.8	10.8	2.0	2.4	3.3
Tanning	0.3	4.1	12.0	-3.5	-0.2	0.5
Hand grip strength (left)	2.4	6.3	12.9	-3.6	2.2	-1.0
Number of treatments/medications taken	0.9	1.6	3.6	1.9	-0.1	-1.0
Average weekly spirits intake	0.3	0.4	0.9	-0.0	-0.5	-0.9
Sensitivity / hurt feelings	0.9	1.5	2.5	-0.3	-1.4	1.6
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	0.0	-0.7	0.3
Hearing difficulty/problems: Yes	0.7	1.1	2.7	1.6	0.7	0.4
Relative age of first facial hair	0.2	0.4	1.0	-0.4	1.0	-0.1
Other serious medical condition/disability diagnosed by doctor	4.3	5.5	13.9	3.7	1.7	0.0
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.1	1.8	-1.0	1.3
Ever had hysterectomy (womb removed)	2.5	2.8	8.1	2.8	0.3	-0.5
Systolic blood pressure, automated reading	1.5	4.3	7.8	-1.7	-1.5	-2.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	1.4	-0.5	0.5
Angina	1.5	2.0	5.4	2.3	0.5	0.4
Medication for hormone replacement therapy	2.1	2.3	4.6	0.3	2.1	1.5
Vitamin and mineral supplements	0.2	0.3	0.8	0.2	-0.9	0.4
Supplements: Zinc	0.4	0.5	0.6	0.8	0.7	-0.6
Medication: Co-codamol	0.8	0.9	1.6	1.3	1.0	0.3
Medication: Metformin	0.6	0.9	1.9	-0.3	1.4	0.9
Diabetes (father)	0.2	0.2	0.4	0.2	-0.6	0.5
Diabetes (mother)	0.8	1.0	1.7	1.0	1.3	-0.6
Severe depression (siblings)	1.1	1.2	1.9	1.4	0.9	0.9
Pack years adult smoking proportion	0.4	0.6	1.4	0.5	0.4	1.2
Impedance of leg (right)	2.2	10.7	24.1	-0.1	2.8	-4.9
Leg fat-free mass (left)	0.2	1.1	2.2	-1.5	-0.5	0.9
Trunk fat percentage	0.1	0.5	0.7	0.6	-0.6	-0.8
Hand grip strength (right)	1.2	3.2	6.5	-2.6	1.7	-0.5
Townsend deprivation index at recruitment	4.0	5.6	7.0	2.6	2.6	1.7
Current tobacco smoking	1.3	2.1	6.1	0.4	0.3	2.5
Average weekly fortified wine intake	1.0	1.2	2.0	1.1	-0.6	1.4
Maternal smoking around birth	0.8	1.2	3.2	0.5	-1.8	0.3
Fed-up feelings	0.4	0.7	1.0	0.0	-1.0	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.4	1.2	0.4	0.6
Relative age voice broke	0.6	0.9	1.5	0.4	1.2	-0.9
Taking other prescription medications	1.6	2.4	4.2	2.1	1.1	-1.4
Age when periods started (menarche)	1.1	2.6	5.9	2.4	0.7	1.2
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.5	1.1	-0.5	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	1.8	1.3	-1.2	0.9
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.4	0.8	-1.5	1.1
Qualifications: CSEs or equivalent	0.2	0.2	0.4	0.6	-0.4	-0.3
Serious illness, injury or assault to yourself	0.7	0.8	1.1	1.1	-0.9	-0.8
High blood pressure	0.6	1.8	3.8	-1.1	-2.0	-0.5
Hayfever, allergic rhinitis or eczema	1.8	3.9	6.0	-2.4	2.4	0.0
Multivitamins +/- minerals	0.4	0.5	1.2	-0.0	1.1	-0.7
Stomach or abdominal pain in last month	1.2	1.5	2.2	-1.1	1.5	-1.1
Supplements: Glucosamine	0.2	0.2	0.4	0.7	-0.5	0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.3	-0.7	0.4
Medication: Atenolol	2.1	2.7	4.3	2.1	1.9	-0.4
Medication: Levothyroxine sodium	0.6	1.0	1.4	1.2	-1.2	-0.2
Sitting height	1.3	9.0	16.6	-4.1	1.1	-3.0
Chronic bronchitis/emphysema (father)	0.7	0.8	1.8	1.3	0.7	-0.1
High blood pressure (mother)	0.9	1.3	2.3	-1.5	-1.1	-0.7
Body mass index (BMI)	0.4	1.9	2.4	1.1	-1.5	1.4
Impedance of leg (left)	1.9	9.4	19.6	-0.1	2.9	-4.4
Leg predicted mass (left)	0.2	1.0	2.2	-1.5	-0.4	0.8
Trunk fat mass	0.1	0.4	0.7	-0.3	-0.7	-0.8
Waist circumference	0.1	0.2	0.7	-0.2	-0.8	-0.1
Number of incorrect matches in round	2.6	4.3	9.2	3.0	-1.0	-1.6
Past tobacco smoking	1.7	3.1	6.1	1.3	2.5	1.2
Alcohol usually taken with meals	0.2	0.2	0.5	-0.2	0.7	-0.4
Nervous feelings	0.3	0.5	1.1	-0.6	-1.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.5	-1.2	-0.3	-0.9
Hearing difficulty/problems with background noise	0.8	1.3	3.3	1.8	0.1	0.7
Hair/balding pattern: Pattern 2	0.3	0.3	0.5	0.7	-0.7	0.4
Had menopause	1.7	2.2	4.8	2.2	-1.3	0.2
Had other major operations	2.4	2.9	6.0	-1.0	-1.3	-2.4
Forced vital capacity (FVC)	1.1	4.4	10.8	-3.3	-0.4	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.3	1.2	-1.0	0.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.1	-1.5	0.4	1.0
Qualifications: None of the above	0.6	1.3	3.7	1.9	-0.3	-0.2
Financial difficulties in last 2 years	0.8	1.1	2.3	1.5	0.5	0.9
Mouth/teeth dental problems	1.1	1.8	2.7	-1.6	-0.0	1.6
Heart attack	0.8	1.1	2.9	1.7	-0.3	0.4
Allergy	2.1	4.8	8.9	1.9	-3.0	1.4
Pain all over the body in last month	2.3	2.4	6.4	-0.7	-0.6	-2.5
Diabetes (self-reported)	0.9	1.4	2.7	1.2	0.3	1.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.9	0.3	1.4	1.2
Medication: Ramipril	1.2	1.6	3.7	-0.5	-0.9	-1.9
Medication: Simvastatin	0.1	0.1	0.2	0.0	0.3	-0.5
Fluid intelligence score	0.7	1.5	4.3	-2.1	-0.3	0.2
Illnesses of siblings	0.6	0.9	1.0	-0.8	1.0	1.0
Neuroticism score	0.5	1.0	2.7	-0.5	-1.6	0.1
Weight	0.1	0.3	0.5	-0.7	-0.7	-0.3
Impedance of arm (right)	0.8	3.6	6.0	-0.6	2.4	-2.1
Arm fat percentage (right)	0.2	0.8	2.0	0.5	-1.4	0.2
Trunk fat-free mass	0.4	2.1	6.2	-2.5	-0.1	-0.2
Hip circumference	0.0	0.1	0.4	-0.1	-0.6	-0.1
Time employed in main current job	0.6	0.7	1.7	-0.2	-1.3	-0.7
Alcohol intake versus 10 years previously	0.5	0.8	1.2	1.1	-1.0	0.2
Father’s age at death	1.6	2.1	2.9	-1.5	-1.7	-1.0
Worrier / anxious feelings	1.0	1.9	4.9	-0.9	-2.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	0.4	1.2	0.3
Falls in the last year	0.2	0.3	0.8	0.3	0.3	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	0.9	-0.9	0.7	0.6
Number of live births	2.3	3.2	5.9	2.4	0.2	1.9
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	13.7	-3.7	-1.1	-0.8
Pulse rate	0.1	0.2	0.5	-0.1	0.2	0.7
Happiness	0.6	0.7	1.8	0.2	-0.6	1.3
Noisy workplace	0.2	0.2	0.3	0.5	-0.5	-0.4
Qualifications: A levels/AS levels or equivalent	1.5	3.3	8.1	-2.8	-0.3	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	2.6	-1.6	0.1	-1.5
Mouth/teeth dental problems: Dentures	0.8	1.4	3.0	1.7	-0.5	1.0
Asthma	1.3	2.5	4.3	1.0	2.1	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.4	-0.0	1.6	0.7
Medication: Cholesterol lowering	0.2	0.3	0.6	0.1	0.4	-0.8
Depression (self-reported)	1.1	1.3	2.4	1.6	0.5	1.2
Medication: Lansoprazole	0.6	0.6	1.9	0.1	-1.4	0.1
Prospective memory result	0.1	0.1	0.1	0.2	-0.2	-0.4
Lung cancer (father)	0.3	0.3	0.6	-0.3	-0.8	0.6
Illnesses of mother	0.8	1.0	2.3	0.8	1.5	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	10.6	-3.3	-1.6	-0.4
Pulse wave Arterial Stiffness index	2.3	2.7	6.6	-0.5	-2.6	-1.1
Impedance of arm (left)	0.6	2.9	5.3	-1.0	1.5	-2.3
Arm fat mass (right)	0.1	0.5	1.5	0.0	-1.2	0.4
Trunk predicted mass	0.3	2.0	5.9	-2.4	-0.1	-0.2
Standing height	1.0	9.9	16.2	-4.0	1.7	-3.3
Length of working week for main job	0.1	0.2	0.4	0.2	0.6	0.0
Exposure to tobacco smoke at home	3.6	4.0	6.9	-1.9	-2.6	-1.2
Breastfed as a baby	1.9	2.3	6.5	0.1	-0.7	2.6
Tense / ‘highly strung’	0.7	1.2	1.8	-1.3	0.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.1	-0.3	-0.9
Hair/balding pattern: Pattern 4	0.9	2.3	5.9	2.4	-0.8	0.4
Birth weight of first child	1.2	2.2	4.6	-2.1	-1.4	0.0
Peak expiratory flow (PEF)	0.9	2.1	5.8	-2.4	0.7	-0.2
Pulse wave reflection index	1.3	1.6	4.5	0.5	-2.1	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.1	0.1	0.4
Loud music exposure frequency	1.3	1.4	1.9	-1.3	-0.8	-1.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.2	-1.5	-0.2	-0.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.4	0.3	1.6	-1.2
Blood clot in the leg (DVT)	0.5	0.6	1.4	-0.1	1.2	-0.7
Medication: Paracetamol	0.9	1.5	3.0	1.1	0.6	-1.7
Headache pain in last month	0.5	0.9	1.7	0.8	0.5	-1.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.8	1.2	-0.5	1.4
Glaucoma (self-reported)	2.0	2.3	6.3	0.0	0.8	-2.5
Gout (self-reported)	1.4	1.9	4.6	-0.2	2.2	-1.0
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.6	1.0	-1.9	-1.0
Medication: Amlodipine	0.5	0.7	1.6	0.6	0.1	1.3
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.9	-0.0	1.7	-0.5
Birth weight	0.2	0.5	1.2	1.1	0.4	-0.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.4	0.2	0.2
High blood pressure (siblings)	1.7	2.4	4.8	0.9	-1.3	-2.2
Forced vital capacity (FVC), Best measure	1.2	4.5	11.2	-3.3	-1.0	-1.1
Body fat percentage	0.2	0.7	0.9	0.7	-0.8	-0.9
Leg fat percentage (right)	0.6	2.1	3.5	0.9	-1.4	-1.9
Arm fat-free mass (right)	0.2	0.9	2.5	-1.6	-0.3	-0.3
Exposure to tobacco smoke outside home	0.6	0.8	1.3	1.1	1.1	0.1
Comparative body size at age 10	0.8	2.3	5.7	0.1	-2.4	1.1
Number of full brothers	2.5	3.2	7.1	2.7	0.3	1.6
Worry too long after embarrassment	0.4	0.7	1.1	-1.0	-1.0	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.8	0.9	-0.1	1.7
Wheeze or whistling in the chest in last year	2.4	4.3	6.3	2.5	1.5	2.1
Number of children fathered	0.7	0.8	1.7	-0.8	-1.3	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.5	-0.9	-0.1	-1.2
Age at first live birth	0.1	0.1	0.2	-0.5	0.4	-0.3
Pulse wave peak to peak time	2.3	2.7	6.8	0.4	2.6	1.1
Health satisfaction	1.2	1.6	3.9	0.6	-2.0	-0.7
Shortness of breath walking on level ground	1.8	2.1	4.7	2.2	-0.4	1.2
Qualifications: College or University degree	2.0	6.4	16.4	-4.0	0.6	-1.6
Eye problems/disorders: None of the above	1.2	1.4	3.1	1.0	-0.3	1.8
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.4	-0.7	-1.3	-1.6
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.4	0.2	0.3
Medication for pain relief, constipation, heartburn	1.1	2.0	3.0	-1.3	-1.1	1.7
Neck or shoulder pain in last month	0.1	0.2	0.2	0.5	-0.4	-0.3
Medication: Blood pressure	0.8	1.5	4.3	-0.4	-0.0	-2.1
Angina (self-reported)	1.4	1.9	5.5	2.3	0.2	0.4
Migraine (self-reported)	0.3	0.4	0.8	0.4	0.9	-0.5
Medication: Ibuprofen	0.6	0.8	1.2	-0.2	1.1	1.0
Medication: Allopurinol	2.0	2.7	7.2	0.1	2.7	-0.9
Medication: Omeprazole	0.7	0.8	1.1	-1.1	-1.0	-0.6
Medication: Seretide 50 evohaler	3.1	3.6	6.4	2.5	2.0	-0.5
Mean time to correctly identify matches	1.5	2.9	7.8	2.8	0.3	0.9
Heart disease (mother)	1.4	1.7	3.9	-1.1	-0.4	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.0	0.6	1.0	0.9
Whole body fat mass	0.1	0.2	0.5	0.1	-0.7	-0.4
Leg fat mass (right)	0.2	0.7	1.0	0.4	-0.9	-1.0
Arm predicted mass (right)	0.1	0.6	1.6	-1.3	-0.4	-0.0
Pulse rate, automated reading	0.3	0.8	1.3	-0.6	0.9	1.1
Alcohol intake frequency.	1.2	2.8	5.0	2.2	-0.3	1.8
Comparative height size at age 10	1.0	5.7	10.3	-2.6	0.1	-3.2
Number of full sisters	1.3	1.5	3.6	1.9	0.9	0.5
Suffer from ‘nerves’	0.4	0.6	1.8	-0.2	-1.3	-0.3
Overall health rating	0.4	0.9	2.7	1.6	-0.1	-0.1
Chest pain or discomfort	0.8	1.2	2.7	1.6	0.9	0.1
Had major operations	0.4	0.5	0.8	-0.7	-0.9	-0.4
Age at last live birth	0.2	0.3	0.9	0.9	0.0	0.3
Family relationship satisfaction	1.2	1.5	2.2	0.5	-1.4	1.5
Leg pain on walking	1.0	1.3	2.2	1.5	-0.6	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.6	-0.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.0	-0.2	1.4	-0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	-0.2	0.6	0.9
Medication: Aspirin	0.6	0.8	1.6	1.3	-0.9	-0.1
Supplements: Vitamin C	0.3	0.3	0.9	0.2	-1.0	-0.3
Knee pain experienced in last month	0.3	0.5	0.6	-0.7	-0.7	0.7
Hypertension (Self-reported)	0.4	1.1	2.6	-0.7	-1.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.8	0.3	-1.3	-1.1
Illnesses of father: Heart disease	0.1	0.1	0.1	-0.1	-0.3	-0.3
Illnesses of siblings: Diabetes	0.5	0.6	1.3	0.7	-1.2	0.1
Smoking status: Previous	1.8	2.7	3.4	-1.3	-1.7	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	7.4	-1.5	2.7	-1.7
Whole body fat-free mass	0.3	1.5	4.4	-2.1	-0.3	0.3
Leg fat-free mass (right)	0.3	1.4	2.7	-1.6	-0.4	1.2
Arm fat percentage (left)	0.3	1.0	2.8	0.4	-1.7	0.2
Average weekly red wine intake	1.8	2.6	4.4	-2.1	-1.5	-1.1
Handedness (chirality/laterality): Left-handed	1.4	1.7	2.6	-1.2	1.1	-1.6
Mood swings	1.6	2.9	7.8	0.6	-2.8	-0.7
Loneliness, isolation	1.8	2.5	7.3	-0.5	-0.0	2.7
Long-standing illness, disability or infirmity	0.6	0.9	1.9	1.4	0.2	-0.8
Ever had bowel cancer screening	0.1	0.2	0.4	-0.2	-0.6	-0.2
Diabetes diagnosed by doctor	0.7	1.2	1.4	1.1	1.0	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	-0.3	0.6	-0.0
Friendships satisfaction	0.5	0.6	0.9	-1.0	0.6	0.8
Qualifications: nursing, teaching	0.3	0.5	1.1	-1.0	0.2	0.7
Commuting to job workplace: Walk	1.0	1.1	3.0	-1.7	-0.5	-0.1
Eye problems/disorders: Cataract	0.1	0.2	0.2	-0.4	0.3	0.5
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	8.8	0.9	0.1	-3.0
Medication for cholesterol	1.2	1.8	2.7	-1.0	-1.6	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	1.9	4.2	2.0	1.0	-0.8
Back pain experienced in last month	0.1	0.1	0.3	0.2	0.6	-0.0
Mineral and other dietary supplements	0.3	0.5	1.2	-1.1	-0.1	-0.5
Breast cancer (self-reported)	0.3	0.3	0.5	-0.7	-0.0	-0.7
Asthma (self-reported)	1.3	2.5	4.4	1.1	2.1	-1.4
Osteoporosis (self-reported)	0.2	0.2	0.4	0.7	0.2	-0.3
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.9	-0.0	0.5
Medication: Aspirin	0.8	1.1	2.7	1.6	-0.7	-0.1
Medication: Gliclazide	0.1	0.1	0.2	-0.1	0.1	0.5
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	1.1	-0.2	-0.2
Smoking status: Current	1.2	1.8	5.4	0.3	0.2	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	-0.4	-0.3	0.7
Whole body water mass	0.3	1.4	4.2	-2.1	-0.2	0.2
Leg predicted mass (right)	0.2	1.3	2.3	-1.5	-0.4	1.2
Arm fat mass (left)	0.2	0.9	2.5	0.2	-1.6	0.2
Number of self-reported non-cancer illnesses	0.5	0.9	1.7	0.9	-0.6	-1.3
Average weekly champagne plus white wine intake	0.5	0.7	1.7	-0.1	0.6	1.3
Miserableness	0.4	0.7	1.9	-1.4	-0.5	-0.1
Guilty feelings	0.3	0.5	1.3	-0.2	-1.1	-0.3
Wears glasses or contact lenses	0.1	0.1	0.1	0.1	-0.4	0.3
Ever taken oral contraceptive pill	0.6	0.7	1.3	0.0	1.1	0.9
Hearing aid user	0.4	0.4	0.7	0.7	-0.8	-0.5
Mother’s age at death	0.0	0.1	0.1	-0.2	0.2	-0.3
Financial situation satisfaction	0.3	0.4	0.6	0.6	-0.4	0.8
Tinnitus: Yes, now most or all of the time	1.7	2.0	3.5	-1.9	-0.0	1.6
Commuting to job workplace: Public transport	0.2	0.3	0.5	-0.0	0.7	0.5
Eye problems/disorders: Glaucoma	1.9	2.2	6.2	-0.6	-0.1	-2.5
Medication: Blood pressure	0.2	0.3	0.7	0.9	-0.3	0.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	1.8	1.3	1.2	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.2	1.1	0.6	0.3
High cholesterol (Self-reported)	0.5	0.9	1.8	0.5	-0.7	-1.4
Medication: Bendroflumethiazide	0.9	1.4	4.0	2.0	-0.3	0.0
Medication: Paracetamol	0.5	0.8	2.1	0.6	-0.1	-1.4
Medication: Lisinopril	0.5	0.7	1.2	1.0	-1.1	0.1
Medication: Atorvastatin	0.6	0.7	1.0	0.8	-0.6	-1.0
Illnesses of father: High blood pressure	1.3	1.6	4.3	-2.1	0.5	-0.7
Alcohol drinker status: Never	1.6	1.9	4.2	-1.1	-2.0	0.4
Ever smoked	1.6	2.7	4.0	-1.1	-2.0	-1.7
Basal metabolic rate	0.2	1.1	3.2	-1.8	-0.2	0.0
Leg fat percentage (left)	0.5	1.7	2.1	1.1	-1.4	-1.4
Arm fat-free mass (left)	0.1	0.3	0.9	-1.0	0.1	-0.1
Number of operations (self-reported)	0.8	1.2	2.6	-0.7	-0.7	-1.6
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.7	-0.6	0.0
Irritability	1.3	2.2	3.4	-1.6	-0.7	-1.8
Risk taking	0.1	0.2	0.5	0.3	0.2	-0.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	-0.9	-1.2	-0.2
Fractured/broken bones in last 5 years	0.6	0.8	1.6	0.2	0.9	-1.2
Age started oral contraceptive pill	1.6	2.0	4.1	1.3	0.5	2.0
Diastolic blood pressure, automated reading	0.4	1.3	1.4	-1.2	-1.1	-1.1
Ever depressed for a whole week	1.1	1.3	3.5	-1.9	0.5	0.5
Unable to work because of sickness or disability	0.7	0.9	2.1	1.5	0.2	-0.7
Commuting to job workplace: Cycle	1.5	1.8	2.6	-1.6	-1.6	0.6
Myopia	0.1	0.2	0.4	0.1	-0.3	-0.6
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.3	-0.0	1.8	-0.1
Cholesterol lowering medication	0.7	1.0	2.6	1.6	-0.5	0.4
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	1.9	-1.4	-1.2	-1.1
Pain experienced in last month	0.2	0.3	0.7	0.2	0.8	0.3
Supplements: Calcium	0.7	0.7	1.4	0.4	1.2	0.8
Basal cell carcinoma (self-reported)	0.9	1.1	1.9	-1.4	-1.1	-0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	1.5	-0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	0.0	1.0	-0.1
Heart disease (siblings)	0.6	0.7	1.3	1.1	-0.9	-0.0
Alcohol drinker status: Previous	0.7	0.8	1.7	-0.5	1.3	0.6
Pack years of smoking	0.5	0.7	1.6	0.8	-0.2	1.3
Impedance of whole body	1.2	6.1	12.6	-0.4	2.4	-3.6
Leg fat mass (left)	0.1	0.5	0.7	0.4	-0.9	-0.8
Arm predicted mass (left)	0.1	0.3	0.8	-0.9	-0.0	-0.2