Hub : Genes

EXOC6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1270	0.0290	1.7e-11	0.151	0.083	0.130	0.121	0.147	5.7e-18	2.8e-10	1.4e-15	1.7e-14	1.7e-17
2	GTEx	Nerve Tibial	0.1891	0.0661	1.6e-03	-0.004	NA	0.048	NA	0.001	9.7e-01	NA	2.6e-04	NA	2.7e-01
3	METSIM	Adipose	0.0692	0.0249	9.0e-05	0.044	0.038	0.036	0.039	0.039	3.6e-07	2.1e-06	3.2e-06	1.3e-06	1.4e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	0.9	-0.3	0.9	-0.9
Bipolar Disorder or Schizophrenia	0.2	0.6	1.1	0.3	1.1	0.7
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	0.1	-0.1	-0.7
Depression (Nagel 2018)	0.4	0.5	0.9	-1.0	0.2	-0.8
Intelligence (Savage-Jansen 2018)	1.2	3.5	8.6	0.8	2.9	1.2
Neuroticism (Nagel 2018)	0.3	0.7	1.7	-1.3	-0.0	0.6
Schizophrenia (2018)	0.6	1.2	2.7	0.7	0.7	1.6
Schizophrenia vs Biploar Disorder	0.5	0.6	1.0	0.3	-0.9	1.0
Worry (Nagel 2018)	0.6	1.2	2.2	-1.1	0.4	1.5
Alzheimer’s Disease (in mother)	2.0	2.3	6.2	-0.8	0.2	2.5
Alzheimer’s Disease (in father)	2.7	2.9	5.7	1.4	2.4	-1.0
Alzheimer’s Disease (including proxy)	0.9	1.3	2.8	0.3	1.7	1.0
Crohns Disease (2017)	1.2	2.7	5.0	-2.2	0.4	1.7
Irritable Bowel Disease (IBD)	1.4	3.4	7.1	-2.7	-1.2	1.3
Ulcerative Colitis (UC)	1.1	2.1	3.9	-1.5	-2.0	0.6
Major Depression (MDD)	0.5	0.6	1.4	-1.2	0.2	0.6
Reaction Time	0.5	1.0	2.3	0.9	0.1	1.5
Verbal and Numeric Reasoning (VNR)	1.5	3.6	9.2	1.2	3.0	0.3
Breast Cancer	0.8	1.8	2.6	-1.6	-1.2	1.2
Ovarian Cancer	0.3	0.4	1.0	0.1	-1.0	-0.3
Prostate Cancer	0.5	0.7	1.3	-1.2	-0.5	0.6
Age at First Birth	0.6	0.9	1.2	1.1	-0.3	1.1
Bipolar Disorder (2011)	1.1	1.1	2.9	1.7	0.6	-0.2
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.4	-0.6	0.0
Coronary Artery Disease (CAD)	0.3	0.3	0.5	-0.3	0.7	-0.7
Crohns Disease (2012)	1.2	2.0	3.3	-1.3	-0.9	1.8
Mean Putamen Volume	0.1	0.1	0.2	-0.1	-0.2	-0.4
Fasting Glucose	1.1	1.3	2.7	1.0	1.7	-0.4
HbA1C	0.1	0.1	0.1	0.0	-0.4	-0.4
HDL Cholesterol	1.4	2.4	4.6	-1.5	-2.1	-0.5
LDL Cholesterol	1.0	1.5	3.5	-0.5	1.9	0.9
Lupus	0.3	0.4	0.7	-0.3	0.6	-0.8
Neuroticism (2016)	1.0	1.4	3.8	-1.9	-0.2	0.6
Primary Biliary Cirrhosis	0.6	0.8	1.3	-0.4	-1.2	0.9
Rheumatoid Arthritis	0.2	0.3	0.5	-0.2	0.7	0.5
Schizophrenia (2014)	0.5	1.1	3.0	0.2	0.5	1.7
Triglycerides	0.8	1.2	3.1	0.7	1.8	0.1
Type 2 Diabetes (T2D) (2012)	4.0	4.6	10.0	-1.7	0.9	3.2
Ulcerative Colitis	3.9	5.7	12.5	-2.1	-3.5	0.3
Blood Eosinophil Count	4.1	31.3	79.2	-3.8	-8.9	-0.2
Blood Platelet Count	1.1	12.8	24.2	4.9	3.6	0.9
Blood Red Count	0.0	0.4	0.6	0.8	0.7	-0.4
Blood White Count	0.8	6.0	10.0	1.0	-2.6	-3.2
Heel T-Score	0.3	2.6	6.2	0.8	1.0	2.5
BMI	0.9	5.1	6.7	2.2	-2.6	-1.9
Height	0.3	6.2	13.5	3.7	0.5	2.2
Waist Hip Ratio (WHR)	0.3	1.3	2.6	0.1	1.2	1.6
Systolic Blood Pressure	0.3	1.5	3.5	0.9	-0.4	1.9
Smoking Status	0.2	0.5	1.5	-0.2	-0.1	-1.2
Allergy or Eczema	0.2	0.4	0.6	-0.5	0.7	0.8
Cardiovascular Disease	0.7	2.5	3.8	1.3	-1.4	1.9
Hypothyroidism (self reported)	1.1	2.4	5.4	-2.3	-0.5	1.3
Respiratory disease	3.4	7.6	16.0	-4.0	-2.6	0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	-0.0	0.1	-0.4
Lung FEV1/FVC ratio	0.4	2.0	4.0	2.0	-1.3	-0.3
Lung FVC	0.9	4.4	12.7	-3.6	0.7	-0.0
Neuroticism	0.9	2.2	4.2	-2.1	-0.6	1.4
Chronotype (morning person)	0.9	2.0	3.6	-1.9	-1.4	0.8
Hair Pigment	0.0	0.4	1.3	0.1	-0.0	-1.1
Tanning	0.2	1.9	5.0	-0.6	-2.2	0.6
Hand grip strength (left)	0.5	1.3	3.4	-0.3	-1.8	0.6
Number of treatments/medications taken	0.4	0.7	1.5	-1.2	-0.5	0.7
Average weekly spirits intake	2.2	2.7	6.2	-2.5	-0.8	-1.1
Sensitivity / hurt feelings	1.4	2.5	5.5	-2.3	-0.9	1.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	-0.8	0.2	-0.5
Hearing difficulty/problems: Yes	1.7	2.6	6.6	2.6	0.9	-0.6
Relative age of first facial hair	0.8	1.6	3.0	1.1	0.6	-1.7
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.3	-1.8	-0.5	0.5
Ever used hormone-replacement therapy (HRT)	2.1	2.7	6.7	-0.4	-1.1	2.6
Ever had hysterectomy (womb removed)	0.8	0.9	1.5	1.2	-0.5	1.0
Systolic blood pressure, automated reading	0.2	0.7	1.3	1.1	-0.2	0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.0	0.9	0.5
Angina	0.3	0.4	0.7	-0.8	0.6	0.5
Medication for hormone replacement therapy	2.6	2.9	6.3	-2.5	-0.6	1.5
Vitamin and mineral supplements	0.8	1.1	2.6	-0.6	-1.6	0.7
Supplements: Zinc	1.9	2.0	5.0	2.2	-0.6	-0.9
Medication: Co-codamol	4.1	4.8	8.1	-2.8	-2.1	1.4
Medication: Metformin	0.1	0.1	0.3	-0.5	-0.3	-0.2
Diabetes (father)	0.8	1.0	1.1	-1.0	-0.9	1.1
Diabetes (mother)	1.1	1.4	2.8	1.7	0.4	-1.1
Severe depression (siblings)	1.3	1.4	3.6	-1.9	-0.5	-0.6
Pack years adult smoking proportion	0.7	1.1	2.4	1.0	-0.1	-1.5
Impedance of leg (right)	0.9	4.6	12.5	1.1	3.5	-0.0
Leg fat-free mass (left)	0.8	4.4	12.6	0.3	-3.5	-0.7
Trunk fat percentage	1.4	5.6	10.3	0.3	-2.6	-3.2
Hand grip strength (right)	0.8	2.3	6.7	-0.1	-2.6	0.4
Townsend deprivation index at recruitment	1.4	2.0	5.5	-2.4	0.2	-0.7
Current tobacco smoking	0.6	1.0	2.3	-0.7	-0.1	-1.5
Average weekly fortified wine intake	0.6	0.7	1.0	0.9	-1.0	-0.6
Maternal smoking around birth	2.1	3.0	5.0	-1.1	-1.7	-2.2
Fed-up feelings	0.7	1.3	3.7	-0.2	-1.9	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.9	-1.4	0.3	-0.1
Relative age voice broke	0.4	0.6	1.6	1.3	-0.2	-0.4
Taking other prescription medications	2.5	3.9	9.5	-3.1	-0.4	1.4
Age when periods started (menarche)	0.2	0.5	0.9	-0.9	-0.2	-0.8
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.8	0.0	-1.7	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.9	1.4	-0.7	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	0.4	1.2	0.4
Qualifications: CSEs or equivalent	1.4	1.9	4.7	-0.8	-2.2	0.5
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.2	0.9	-0.6
High blood pressure	1.4	3.8	5.7	-0.6	-2.4	2.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	0.0	0.9	-0.5
Multivitamins +/- minerals	0.7	0.9	2.1	0.7	1.5	-0.1
Stomach or abdominal pain in last month	0.6	0.8	1.4	-0.8	0.6	1.2
Supplements: Glucosamine	2.2	2.8	4.4	2.1	1.9	-0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	-1.2	0.2	0.3
Medication: Atenolol	0.7	0.9	1.8	-0.8	-0.5	1.3
Medication: Levothyroxine sodium	0.7	1.2	2.4	-1.6	-0.6	0.9
Sitting height	0.2	1.3	2.1	0.8	-1.4	-1.1
Chronic bronchitis/emphysema (father)	1.4	1.6	3.0	0.5	1.2	-1.7
High blood pressure (mother)	1.1	1.5	2.4	1.5	-0.7	1.3
Body mass index (BMI)	1.1	4.6	9.0	0.6	-3.0	-2.1
Impedance of leg (left)	0.7	3.2	8.1	1.1	2.8	0.4
Leg predicted mass (left)	0.9	4.6	13.2	0.3	-3.6	-0.7
Trunk fat mass	1.4	5.8	10.1	0.7	-3.2	-2.6
Waist circumference	1.0	3.8	7.2	1.0	-2.7	-1.8
Number of incorrect matches in round	0.3	0.5	1.5	-1.2	-0.1	0.3
Past tobacco smoking	0.2	0.3	0.3	0.5	-0.6	-0.5
Alcohol usually taken with meals	1.2	2.0	4.2	0.9	-1.0	2.0
Nervous feelings	0.6	1.2	2.5	-1.0	0.4	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	3.6	-1.9	0.9	1.9
Hearing difficulty/problems with background noise	0.8	1.3	2.5	1.6	0.9	-0.7
Hair/balding pattern: Pattern 2	1.1	1.3	2.7	0.1	-1.6	-1.2
Had menopause	0.5	0.7	1.3	1.1	0.5	0.7
Had other major operations	0.5	0.6	1.4	-0.6	-1.2	-0.1
Forced vital capacity (FVC)	0.5	2.0	4.9	-2.2	-1.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.5	1.2	-0.9	-0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.2	-0.7	1.1	1.0
Qualifications: None of the above	0.7	1.4	2.3	-1.4	-1.5	0.0
Financial difficulties in last 2 years	0.9	1.2	1.9	-1.4	-0.3	-1.3
Mouth/teeth dental problems	0.8	1.3	2.4	1.5	1.0	0.8
Heart attack	0.1	0.1	0.1	-0.0	0.4	0.4
Allergy	0.4	0.8	1.4	1.2	0.6	-0.8
Pain all over the body in last month	0.6	0.6	1.4	0.2	-1.2	0.6
Diabetes (self-reported)	0.2	0.3	0.8	0.2	0.2	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.0	-1.0	0.1	-1.0
Medication: Ramipril	1.9	2.5	7.2	-0.3	-2.7	0.4
Medication: Simvastatin	0.6	0.9	2.3	-0.1	1.5	-0.4
Fluid intelligence score	1.8	3.7	6.0	2.2	2.4	0.7
Illnesses of siblings	1.3	1.8	3.2	1.1	1.0	-1.8
Neuroticism score	0.8	1.8	2.2	-1.5	-1.0	1.5
Weight	1.0	4.9	10.7	1.3	-3.3	-1.5
Impedance of arm (right)	0.9	4.4	7.6	-0.6	2.3	-2.8
Arm fat percentage (right)	2.0	7.7	16.3	0.5	-2.6	-4.0
Trunk fat-free mass	0.6	3.4	6.5	1.7	-2.5	0.9
Hip circumference	1.4	6.1	11.5	1.4	-3.4	-2.2
Time employed in main current job	0.9	1.1	1.7	-1.2	0.2	1.3
Alcohol intake versus 10 years previously	0.8	1.2	2.3	-0.8	-0.8	-1.5
Father’s age at death	0.7	1.0	1.5	-0.3	1.2	1.1
Worrier / anxious feelings	2.1	4.1	8.3	-2.9	-1.9	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.0	4.1	-2.0	-1.0	1.0
Falls in the last year	0.5	0.6	1.1	-1.0	-0.6	-0.7
Hair/balding pattern: Pattern 3	0.6	0.9	1.7	0.8	1.3	-0.7
Number of live births	0.4	0.5	1.0	-1.0	-0.7	0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.1	-1.4	-1.3	-0.6
Pulse rate	0.5	0.9	2.0	0.6	0.6	-1.4
Happiness	2.2	2.6	4.8	0.9	2.2	-1.5
Noisy workplace	0.8	1.0	2.1	-1.4	-0.7	-0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	0.6	0.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	0.3	0.4	-0.4
Mouth/teeth dental problems: Dentures	1.5	2.5	3.6	-1.6	-1.2	-1.9
Asthma	3.1	6.1	10.4	-3.2	-2.5	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	4.0	2.0	-0.5	-0.9
Medication: Cholesterol lowering	1.3	2.0	2.8	1.4	1.7	-1.1
Depression (self-reported)	0.3	0.4	1.1	-1.0	-0.1	0.1
Medication: Lansoprazole	0.7	0.8	1.2	0.3	1.1	-1.0
Prospective memory result	0.1	0.2	0.5	-0.2	0.7	0.1
Lung cancer (father)	0.8	0.9	2.3	0.4	0.5	-1.5
Illnesses of mother	0.4	0.5	0.7	-0.7	0.8	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.1	-2.0	-1.6	-0.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.5	-0.6	0.7	-0.2
Impedance of arm (left)	0.7	3.3	5.2	-0.8	2.0	-2.3
Arm fat mass (right)	1.5	6.2	9.1	1.0	-2.9	-3.0
Trunk predicted mass	0.6	3.3	6.6	1.6	-2.6	0.8
Standing height	0.2	1.6	3.1	1.8	-0.7	1.1
Length of working week for main job	0.3	0.3	0.6	-0.5	0.3	0.7
Exposure to tobacco smoke at home	1.3	1.5	4.4	-0.0	-2.1	-0.3
Breastfed as a baby	0.8	1.0	2.5	1.6	0.2	-0.7
Tense / ‘highly strung’	0.3	0.4	1.1	0.3	0.2	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.7	-1.3	-1.3	0.1
Hair/balding pattern: Pattern 4	0.3	0.7	1.0	-1.0	0.5	-0.8
Birth weight of first child	0.5	0.8	2.4	-0.4	-0.0	1.6
Peak expiratory flow (PEF)	0.3	0.7	1.9	-0.1	-1.4	-0.5
Pulse wave reflection index	0.8	0.9	2.6	-1.6	-0.3	0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.1	-0.6	0.1
Loud music exposure frequency	0.6	0.6	1.0	0.5	1.0	-0.8
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.3	-0.0	0.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.3	1.1	-0.7	0.9
Blood clot in the leg (DVT)	0.2	0.2	0.3	0.4	-0.3	0.6
Medication: Paracetamol	1.1	1.8	1.9	-1.4	-1.4	1.2
Headache pain in last month	0.7	1.2	2.7	-1.6	-1.0	-0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	-0.3	0.9	-0.2
Glaucoma (self-reported)	5.5	6.5	12.5	-2.5	-3.5	0.8
Gout (self-reported)	0.2	0.3	0.4	-0.6	-0.2	-0.6
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	6.8	-2.6	0.0	1.1
Medication: Amlodipine	3.5	5.0	6.3	-2.5	-2.0	2.2
Medication: Ventolin 100micrograms inhaler	2.1	2.7	6.0	-2.5	0.2	1.5
Birth weight	1.4	3.0	8.4	0.3	-2.9	0.6
Chronic bronchitis/emphysema (mother)	1.8	2.1	3.5	-1.9	-0.7	-1.5
High blood pressure (siblings)	1.0	1.4	4.1	-0.3	-0.2	2.0
Forced vital capacity (FVC), Best measure	0.8	3.0	6.9	-2.6	-1.4	0.3
Body fat percentage	1.2	4.9	8.6	0.5	-2.4	-2.9
Leg fat percentage (right)	1.0	3.5	4.7	0.9	-2.2	-2.2
Arm fat-free mass (right)	0.8	4.0	9.8	1.2	-3.1	0.8
Exposure to tobacco smoke outside home	0.5	0.7	1.7	-1.3	-0.0	-0.5
Comparative body size at age 10	1.0	2.8	7.2	0.2	-2.7	-1.0
Number of full brothers	4.0	5.0	10.9	-3.3	-1.6	1.3
Worry too long after embarrassment	1.2	2.1	3.7	-1.9	-1.3	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.3	-1.1	-0.4	-0.0
Wheeze or whistling in the chest in last year	2.0	3.5	6.1	-2.5	-1.7	1.3
Number of children fathered	0.1	0.1	0.4	0.7	0.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.6	-1.0	0.1	1.6
Age at first live birth	0.6	1.1	2.7	1.6	-0.6	-0.3
Pulse wave peak to peak time	0.5	0.6	1.0	1.0	-1.0	0.2
Health satisfaction	0.4	0.5	1.0	0.8	0.1	1.0
Shortness of breath walking on level ground	0.4	0.5	1.2	1.1	0.4	0.5
Qualifications: College or University degree	1.1	3.6	6.8	1.7	2.6	1.2
Eye problems/disorders: None of the above	2.5	2.9	4.4	2.1	2.1	-0.4
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.8	-0.7	-1.0	1.9
Emphysema/chronic bronchitis	1.8	2.0	5.6	-2.4	0.2	-0.7
Medication for pain relief, constipation, heartburn	0.3	0.6	1.7	0.1	0.3	-1.3
Neck or shoulder pain in last month	0.6	0.8	1.3	-1.1	-0.7	0.7
Medication: Blood pressure	1.3	2.3	5.7	-0.4	-2.4	1.0
Angina (self-reported)	0.3	0.5	0.8	-0.9	0.7	0.3
Migraine (self-reported)	0.5	0.7	1.0	-0.7	-1.0	-0.8
Medication: Ibuprofen	1.0	1.2	1.7	1.3	-1.2	-0.7
Medication: Allopurinol	0.5	0.6	1.3	-0.7	-1.1	-0.2
Medication: Omeprazole	0.9	1.1	1.4	-1.2	1.0	0.9
Medication: Seretide 50 evohaler	2.7	3.1	6.4	-2.5	-1.7	0.2
Mean time to correctly identify matches	0.5	0.9	1.5	0.9	0.7	1.2
Heart disease (mother)	0.5	0.7	1.0	-0.8	-1.0	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	1.7	-1.0	-1.3	-1.2
Whole body fat mass	1.2	5.1	8.8	0.9	-3.0	-2.4
Leg fat mass (right)	1.0	4.0	6.5	1.2	-2.5	-2.0
Arm predicted mass (right)	0.8	4.0	8.9	1.3	-3.0	1.1
Pulse rate, automated reading	0.5	1.6	2.2	0.9	1.3	-1.5
Alcohol intake frequency.	0.4	1.0	1.9	-1.4	0.9	-0.4
Comparative height size at age 10	0.1	0.6	1.7	0.4	-1.3	-0.3
Number of full sisters	0.8	0.9	1.7	-1.3	1.0	0.2
Suffer from ‘nerves’	1.7	2.6	7.3	-0.7	0.1	2.7
Overall health rating	1.4	3.1	5.1	-1.6	-1.3	2.2
Chest pain or discomfort	0.2	0.2	0.7	0.0	-0.0	0.8
Had major operations	0.3	0.3	0.8	0.2	0.4	0.9
Age at last live birth	0.9	1.3	2.4	1.6	-1.2	0.0
Family relationship satisfaction	0.4	0.5	0.6	0.8	-0.8	-0.6
Leg pain on walking	0.2	0.2	0.7	-0.8	-0.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.7	5.3	-0.9	-2.3	-1.4
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.5	0.5	0.7	0.7
Illness, injury, bereavement, stress in last 2 years	1.9	2.4	4.3	-0.9	-1.4	2.1
Medication: Aspirin	0.4	0.5	1.1	1.1	0.1	0.5
Supplements: Vitamin C	0.6	0.7	1.8	1.3	0.2	-0.4
Knee pain experienced in last month	0.4	0.7	2.0	0.0	-1.4	0.2
Hypertension (Self-reported)	1.0	2.9	5.0	-0.0	-2.2	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	7.1	0.0	2.7	0.2
Illnesses of father: Heart disease	0.2	0.3	0.7	0.1	0.1	0.9
Illnesses of siblings: Diabetes	1.7	2.1	3.4	-1.7	-0.6	1.8
Smoking status: Previous	0.3	0.4	0.6	0.7	0.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.3	0.1	-2.1	-1.2
Whole body fat-free mass	0.7	3.8	9.9	1.2	-3.1	0.4
Leg fat-free mass (right)	1.0	5.5	16.2	0.2	-4.0	-0.4
Arm fat percentage (left)	1.8	7.4	15.3	0.4	-2.6	-3.9
Average weekly red wine intake	0.5	0.8	2.3	0.0	-0.1	1.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.2	-0.4	0.4
Mood swings	0.2	0.4	0.6	-0.5	-0.8	0.5
Loneliness, isolation	0.3	0.5	1.3	1.1	0.3	-0.1
Long-standing illness, disability or infirmity	0.8	1.2	1.9	-1.3	-1.4	-0.4
Ever had bowel cancer screening	0.7	0.9	2.3	-1.5	0.5	0.3
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.2	0.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.0	-1.0	0.1	-0.9
Friendships satisfaction	0.9	1.2	1.3	1.1	1.1	-1.0
Qualifications: nursing, teaching	1.6	2.4	4.9	2.2	1.3	-0.8
Commuting to job workplace: Walk	0.2	0.3	0.6	-0.8	0.4	0.1
Eye problems/disorders: Cataract	1.0	1.2	2.8	-1.7	-0.9	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.3	-0.0	1.5	0.4
Medication for cholesterol	0.8	1.2	3.3	-0.6	-0.1	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	-0.8	-0.1	0.1
Back pain experienced in last month	1.1	1.6	4.4	2.1	0.4	-0.6
Mineral and other dietary supplements	1.7	2.3	4.0	-2.0	-1.7	-0.2
Breast cancer (self-reported)	1.6	1.9	2.5	1.6	1.3	-1.2
Asthma (self-reported)	3.3	6.5	10.9	-3.3	-2.6	1.3
Osteoporosis (self-reported)	0.6	0.8	1.4	-0.5	0.8	1.2
Osteoarthritis (self-reported)	0.6	0.8	1.5	-1.2	-0.7	0.7
Medication: Aspirin	0.4	0.5	1.1	1.0	0.0	0.7
Medication: Gliclazide	1.1	1.2	2.5	-0.4	-1.0	-1.6
Illnesses of father: None of the above (group 1)	0.8	1.0	2.1	-0.5	-1.5	0.7
Smoking status: Current	0.7	1.1	1.9	-1.1	0.2	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	6.4	-2.5	-1.8	-0.3
Whole body water mass	0.7	3.9	10.0	1.2	-3.2	0.4
Leg predicted mass (right)	1.0	5.4	16.2	0.2	-4.0	-0.4
Arm fat mass (left)	1.5	6.1	8.9	1.1	-2.9	-3.0
Number of self-reported non-cancer illnesses	1.4	2.4	4.5	-2.1	-0.9	1.4
Average weekly champagne plus white wine intake	0.9	1.2	2.6	1.6	0.7	0.7
Miserableness	0.3	0.6	1.3	-1.1	-0.4	0.5
Guilty feelings	1.9	2.8	5.2	-1.5	-1.0	2.3
Wears glasses or contact lenses	0.4	0.5	0.7	-0.6	-0.6	0.9
Ever taken oral contraceptive pill	0.7	0.8	2.2	-0.4	-0.3	-1.5
Hearing aid user	2.5	2.8	7.5	2.7	0.9	-0.4
Mother’s age at death	0.6	0.8	1.7	0.7	0.3	1.3
Financial situation satisfaction	1.0	1.3	3.1	-1.8	0.8	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.3	-0.4	-0.3
Commuting to job workplace: Public transport	2.6	3.1	7.3	-2.7	0.6	1.3
Eye problems/disorders: Glaucoma	6.3	7.5	15.1	-2.7	-3.9	0.5
Medication: Blood pressure	0.8	1.5	3.2	0.9	-0.6	1.8
Pain type(s) experienced in last month: Hip pain	1.0	1.2	1.9	-1.4	-0.6	-1.2
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.9	1.7	1.1	-0.3
High cholesterol (Self-reported)	1.0	1.7	3.3	1.3	1.8	0.2
Medication: Bendroflumethiazide	2.1	3.2	9.3	3.1	-0.3	-0.2
Medication: Paracetamol	0.7	1.1	1.8	-1.4	-0.8	0.9
Medication: Lisinopril	1.0	1.2	2.0	1.4	-0.1	-1.3
Medication: Atorvastatin	0.6	0.8	1.8	1.3	-0.4	-0.7
Illnesses of father: High blood pressure	1.2	1.4	1.8	-1.1	-1.4	1.1
Alcohol drinker status: Never	1.4	1.7	3.3	1.0	1.8	0.8
Ever smoked	0.0	0.0	0.1	-0.2	-0.1	0.1
Basal metabolic rate	0.8	4.3	10.9	1.3	-3.3	-0.2
Leg fat percentage (left)	1.1	3.9	7.5	0.9	-2.7	-1.8
Arm fat-free mass (left)	0.7	3.8	8.6	1.6	-2.9	0.5
Number of operations (self-reported)	0.5	0.7	1.7	0.2	-1.3	0.7
Average weekly beer plus cider intake	0.6	0.9	1.5	1.2	-0.4	-0.9
Irritability	0.5	0.8	2.0	-0.5	0.3	1.4
Risk taking	0.4	0.6	0.8	0.9	0.8	0.7
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.0	1.0	0.4	-0.3
Fractured/broken bones in last 5 years	0.1	0.1	0.1	0.4	-0.4	0.1
Age started oral contraceptive pill	0.1	0.1	0.3	0.2	0.1	0.6
Diastolic blood pressure, automated reading	0.4	1.3	1.9	1.4	-0.7	-1.2
Ever depressed for a whole week	1.2	1.4	2.7	-0.5	1.2	1.6
Unable to work because of sickness or disability	1.1	1.4	2.3	-1.5	-0.2	1.4
Commuting to job workplace: Cycle	1.1	1.3	1.9	1.4	1.2	-0.8
Myopia	0.7	1.0	1.6	-1.3	0.3	1.1
Vascular/heart problems diagnosed by doctor	1.1	3.1	4.6	0.6	2.1	-2.1
Cholesterol lowering medication	0.4	0.6	1.3	0.8	1.1	0.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.1	-1.4	0.7	0.7
Pain experienced in last month	0.4	0.7	2.2	-0.2	1.5	-0.2
Supplements: Calcium	0.5	0.5	1.3	0.4	0.3	1.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.1	0.1	0.8
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.1	0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.5	-0.4	0.7
Heart disease (siblings)	0.6	0.7	1.6	-1.3	-0.3	0.7
Alcohol drinker status: Previous	2.8	3.2	9.7	-3.1	0.1	0.0
Pack years of smoking	0.9	1.3	3.3	0.8	-0.2	-1.8
Impedance of whole body	0.5	2.4	5.7	-0.2	2.4	-1.2
Leg fat mass (left)	1.1	4.3	8.2	1.2	-2.9	-1.8
Arm predicted mass (left)	0.8	4.1	8.8	1.8	-3.0	0.4