Hub : Genes

EXOC6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1270 0.0290 1.7e-11 0.151 0.083 0.130 0.121 0.147 5.7e-18 2.8e-10 1.4e-15 1.7e-14 1.7e-17
2 GTEx Nerve Tibial 0.1891 0.0661 1.6e-03 -0.004 NA 0.048 NA 0.001 9.7e-01 NA 2.6e-04 NA 2.7e-01
3 METSIM Adipose 0.0692 0.0249 9.0e-05 0.044 0.038 0.036 0.039 0.039 3.6e-07 2.1e-06 3.2e-06 1.3e-06 1.4e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.6 0.9 -0.3 0.9 -0.9
Bipolar Disorder or Schizophrenia 0.2 0.6 1.1 0.3 1.1 0.7
Depressed Affect (Nagel 2018) 0.1 0.2 0.5 0.1 -0.1 -0.7
Depression (Nagel 2018) 0.4 0.5 0.9 -1.0 0.2 -0.8
Intelligence (Savage-Jansen 2018) 1.2 3.5 8.6 0.8 2.9 1.2
Neuroticism (Nagel 2018) 0.3 0.7 1.7 -1.3 -0.0 0.6
Schizophrenia (2018) 0.6 1.2 2.7 0.7 0.7 1.6
Schizophrenia vs Biploar Disorder 0.5 0.6 1.0 0.3 -0.9 1.0
Worry (Nagel 2018) 0.6 1.2 2.2 -1.1 0.4 1.5
Alzheimer’s Disease (in mother) 2.0 2.3 6.2 -0.8 0.2 2.5
Alzheimer’s Disease (in father) 2.7 2.9 5.7 1.4 2.4 -1.0
Alzheimer’s Disease (including proxy) 0.9 1.3 2.8 0.3 1.7 1.0
Crohns Disease (2017) 1.2 2.7 5.0 -2.2 0.4 1.7
Irritable Bowel Disease (IBD) 1.4 3.4 7.1 -2.7 -1.2 1.3
Ulcerative Colitis (UC) 1.1 2.1 3.9 -1.5 -2.0 0.6
Major Depression (MDD) 0.5 0.6 1.4 -1.2 0.2 0.6
Reaction Time 0.5 1.0 2.3 0.9 0.1 1.5
Verbal and Numeric Reasoning (VNR) 1.5 3.6 9.2 1.2 3.0 0.3
Breast Cancer 0.8 1.8 2.6 -1.6 -1.2 1.2
Ovarian Cancer 0.3 0.4 1.0 0.1 -1.0 -0.3
Prostate Cancer 0.5 0.7 1.3 -1.2 -0.5 0.6
Age at First Birth 0.6 0.9 1.2 1.1 -0.3 1.1
Bipolar Disorder (2011) 1.1 1.1 2.9 1.7 0.6 -0.2
Body Mass Index (BMI) (2010) 0.1 0.2 0.4 0.4 -0.6 0.0
Coronary Artery Disease (CAD) 0.3 0.3 0.5 -0.3 0.7 -0.7
Crohns Disease (2012) 1.2 2.0 3.3 -1.3 -0.9 1.8
Mean Putamen Volume 0.1 0.1 0.2 -0.1 -0.2 -0.4
Fasting Glucose 1.1 1.3 2.7 1.0 1.7 -0.4
HbA1C 0.1 0.1 0.1 0.0 -0.4 -0.4
HDL Cholesterol 1.4 2.4 4.6 -1.5 -2.1 -0.5
LDL Cholesterol 1.0 1.5 3.5 -0.5 1.9 0.9
Lupus 0.3 0.4 0.7 -0.3 0.6 -0.8
Neuroticism (2016) 1.0 1.4 3.8 -1.9 -0.2 0.6
Primary Biliary Cirrhosis 0.6 0.8 1.3 -0.4 -1.2 0.9
Rheumatoid Arthritis 0.2 0.3 0.5 -0.2 0.7 0.5
Schizophrenia (2014) 0.5 1.1 3.0 0.2 0.5 1.7
Triglycerides 0.8 1.2 3.1 0.7 1.8 0.1
Type 2 Diabetes (T2D) (2012) 4.0 4.6 10.0 -1.7 0.9 3.2
Ulcerative Colitis 3.9 5.7 12.5 -2.1 -3.5 0.3
Blood Eosinophil Count 4.1 31.3 79.2 -3.8 -8.9 -0.2
Blood Platelet Count 1.1 12.8 24.2 4.9 3.6 0.9
Blood Red Count 0.0 0.4 0.6 0.8 0.7 -0.4
Blood White Count 0.8 6.0 10.0 1.0 -2.6 -3.2
Heel T-Score 0.3 2.6 6.2 0.8 1.0 2.5
BMI 0.9 5.1 6.7 2.2 -2.6 -1.9
Height 0.3 6.2 13.5 3.7 0.5 2.2
Waist Hip Ratio (WHR) 0.3 1.3 2.6 0.1 1.2 1.6
Systolic Blood Pressure 0.3 1.5 3.5 0.9 -0.4 1.9
Smoking Status 0.2 0.5 1.5 -0.2 -0.1 -1.2
Allergy or Eczema 0.2 0.4 0.6 -0.5 0.7 0.8
Cardiovascular Disease 0.7 2.5 3.8 1.3 -1.4 1.9
Hypothyroidism (self reported) 1.1 2.4 5.4 -2.3 -0.5 1.3
Respiratory disease 3.4 7.6 16.0 -4.0 -2.6 0.2
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.2 -0.0 0.1 -0.4
Lung FEV1/FVC ratio 0.4 2.0 4.0 2.0 -1.3 -0.3
Lung FVC 0.9 4.4 12.7 -3.6 0.7 -0.0
Neuroticism 0.9 2.2 4.2 -2.1 -0.6 1.4
Chronotype (morning person) 0.9 2.0 3.6 -1.9 -1.4 0.8
Hair Pigment 0.0 0.4 1.3 0.1 -0.0 -1.1
Tanning 0.2 1.9 5.0 -0.6 -2.2 0.6
Hand grip strength (left) 0.5 1.3 3.4 -0.3 -1.8 0.6
Number of treatments/medications taken 0.4 0.7 1.5 -1.2 -0.5 0.7
Average weekly spirits intake 2.2 2.7 6.2 -2.5 -0.8 -1.1
Sensitivity / hurt feelings 1.4 2.5 5.5 -2.3 -0.9 1.0
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.6 -0.8 0.2 -0.5
Hearing difficulty/problems: Yes 1.7 2.6 6.6 2.6 0.9 -0.6
Relative age of first facial hair 0.8 1.6 3.0 1.1 0.6 -1.7
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 3.3 -1.8 -0.5 0.5
Ever used hormone-replacement therapy (HRT) 2.1 2.7 6.7 -0.4 -1.1 2.6
Ever had hysterectomy (womb removed) 0.8 0.9 1.5 1.2 -0.5 1.0
Systolic blood pressure, automated reading 0.2 0.7 1.3 1.1 -0.2 0.8
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.7 0.0 0.9 0.5
Angina 0.3 0.4 0.7 -0.8 0.6 0.5
Medication for hormone replacement therapy 2.6 2.9 6.3 -2.5 -0.6 1.5
Vitamin and mineral supplements 0.8 1.1 2.6 -0.6 -1.6 0.7
Supplements: Zinc 1.9 2.0 5.0 2.2 -0.6 -0.9
Medication: Co-codamol 4.1 4.8 8.1 -2.8 -2.1 1.4
Medication: Metformin 0.1 0.1 0.3 -0.5 -0.3 -0.2
Diabetes (father) 0.8 1.0 1.1 -1.0 -0.9 1.1
Diabetes (mother) 1.1 1.4 2.8 1.7 0.4 -1.1
Severe depression (siblings) 1.3 1.4 3.6 -1.9 -0.5 -0.6
Pack years adult smoking proportion 0.7 1.1 2.4 1.0 -0.1 -1.5
Impedance of leg (right) 0.9 4.6 12.5 1.1 3.5 -0.0
Leg fat-free mass (left) 0.8 4.4 12.6 0.3 -3.5 -0.7
Trunk fat percentage 1.4 5.6 10.3 0.3 -2.6 -3.2
Hand grip strength (right) 0.8 2.3 6.7 -0.1 -2.6 0.4
Townsend deprivation index at recruitment 1.4 2.0 5.5 -2.4 0.2 -0.7
Current tobacco smoking 0.6 1.0 2.3 -0.7 -0.1 -1.5
Average weekly fortified wine intake 0.6 0.7 1.0 0.9 -1.0 -0.6
Maternal smoking around birth 2.1 3.0 5.0 -1.1 -1.7 -2.2
Fed-up feelings 0.7 1.3 3.7 -0.2 -1.9 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.9 -1.4 0.3 -0.1
Relative age voice broke 0.4 0.6 1.6 1.3 -0.2 -0.4
Taking other prescription medications 2.5 3.9 9.5 -3.1 -0.4 1.4
Age when periods started (menarche) 0.2 0.5 0.9 -0.9 -0.2 -0.8
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 2.8 0.0 -1.7 1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 1.9 1.4 -0.7 0.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.3 0.4 1.2 0.4
Qualifications: CSEs or equivalent 1.4 1.9 4.7 -0.8 -2.2 0.5
Serious illness, injury or assault to yourself 0.3 0.4 0.8 -0.2 0.9 -0.6
High blood pressure 1.4 3.8 5.7 -0.6 -2.4 2.3
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.9 0.0 0.9 -0.5
Multivitamins +/- minerals 0.7 0.9 2.1 0.7 1.5 -0.1
Stomach or abdominal pain in last month 0.6 0.8 1.4 -0.8 0.6 1.2
Supplements: Glucosamine 2.2 2.8 4.4 2.1 1.9 -0.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.4 -1.2 0.2 0.3
Medication: Atenolol 0.7 0.9 1.8 -0.8 -0.5 1.3
Medication: Levothyroxine sodium 0.7 1.2 2.4 -1.6 -0.6 0.9
Sitting height 0.2 1.3 2.1 0.8 -1.4 -1.1
Chronic bronchitis/emphysema (father) 1.4 1.6 3.0 0.5 1.2 -1.7
High blood pressure (mother) 1.1 1.5 2.4 1.5 -0.7 1.3
Body mass index (BMI) 1.1 4.6 9.0 0.6 -3.0 -2.1
Impedance of leg (left) 0.7 3.2 8.1 1.1 2.8 0.4
Leg predicted mass (left) 0.9 4.6 13.2 0.3 -3.6 -0.7
Trunk fat mass 1.4 5.8 10.1 0.7 -3.2 -2.6
Waist circumference 1.0 3.8 7.2 1.0 -2.7 -1.8
Number of incorrect matches in round 0.3 0.5 1.5 -1.2 -0.1 0.3
Past tobacco smoking 0.2 0.3 0.3 0.5 -0.6 -0.5
Alcohol usually taken with meals 1.2 2.0 4.2 0.9 -1.0 2.0
Nervous feelings 0.6 1.2 2.5 -1.0 0.4 1.6
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 3.6 -1.9 0.9 1.9
Hearing difficulty/problems with background noise 0.8 1.3 2.5 1.6 0.9 -0.7
Hair/balding pattern: Pattern 2 1.1 1.3 2.7 0.1 -1.6 -1.2
Had menopause 0.5 0.7 1.3 1.1 0.5 0.7
Had other major operations 0.5 0.6 1.4 -0.6 -1.2 -0.1
Forced vital capacity (FVC) 0.5 2.0 4.9 -2.2 -1.1 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.5 1.2 -0.9 -0.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.2 -0.7 1.1 1.0
Qualifications: None of the above 0.7 1.4 2.3 -1.4 -1.5 0.0
Financial difficulties in last 2 years 0.9 1.2 1.9 -1.4 -0.3 -1.3
Mouth/teeth dental problems 0.8 1.3 2.4 1.5 1.0 0.8
Heart attack 0.1 0.1 0.1 -0.0 0.4 0.4
Allergy 0.4 0.8 1.4 1.2 0.6 -0.8
Pain all over the body in last month 0.6 0.6 1.4 0.2 -1.2 0.6
Diabetes (self-reported) 0.2 0.3 0.8 0.2 0.2 0.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.0 -1.0 0.1 -1.0
Medication: Ramipril 1.9 2.5 7.2 -0.3 -2.7 0.4
Medication: Simvastatin 0.6 0.9 2.3 -0.1 1.5 -0.4
Fluid intelligence score 1.8 3.7 6.0 2.2 2.4 0.7
Illnesses of siblings 1.3 1.8 3.2 1.1 1.0 -1.8
Neuroticism score 0.8 1.8 2.2 -1.5 -1.0 1.5
Weight 1.0 4.9 10.7 1.3 -3.3 -1.5
Impedance of arm (right) 0.9 4.4 7.6 -0.6 2.3 -2.8
Arm fat percentage (right) 2.0 7.7 16.3 0.5 -2.6 -4.0
Trunk fat-free mass 0.6 3.4 6.5 1.7 -2.5 0.9
Hip circumference 1.4 6.1 11.5 1.4 -3.4 -2.2
Time employed in main current job 0.9 1.1 1.7 -1.2 0.2 1.3
Alcohol intake versus 10 years previously 0.8 1.2 2.3 -0.8 -0.8 -1.5
Father’s age at death 0.7 1.0 1.5 -0.3 1.2 1.1
Worrier / anxious feelings 2.1 4.1 8.3 -2.9 -1.9 0.6
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.0 4.1 -2.0 -1.0 1.0
Falls in the last year 0.5 0.6 1.1 -1.0 -0.6 -0.7
Hair/balding pattern: Pattern 3 0.6 0.9 1.7 0.8 1.3 -0.7
Number of live births 0.4 0.5 1.0 -1.0 -0.7 0.2
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.1 -1.4 -1.3 -0.6
Pulse rate 0.5 0.9 2.0 0.6 0.6 -1.4
Happiness 2.2 2.6 4.8 0.9 2.2 -1.5
Noisy workplace 0.8 1.0 2.1 -1.4 -0.7 -0.6
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.4 0.6 0.1 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 0.3 0.4 -0.4
Mouth/teeth dental problems: Dentures 1.5 2.5 3.6 -1.6 -1.2 -1.9
Asthma 3.1 6.1 10.4 -3.2 -2.5 1.3
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 4.0 2.0 -0.5 -0.9
Medication: Cholesterol lowering 1.3 2.0 2.8 1.4 1.7 -1.1
Depression (self-reported) 0.3 0.4 1.1 -1.0 -0.1 0.1
Medication: Lansoprazole 0.7 0.8 1.2 0.3 1.1 -1.0
Prospective memory result 0.1 0.2 0.5 -0.2 0.7 0.1
Lung cancer (father) 0.8 0.9 2.3 0.4 0.5 -1.5
Illnesses of mother 0.4 0.5 0.7 -0.7 0.8 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 4.1 -2.0 -1.6 -0.1
Pulse wave Arterial Stiffness index 0.3 0.3 0.5 -0.6 0.7 -0.2
Impedance of arm (left) 0.7 3.3 5.2 -0.8 2.0 -2.3
Arm fat mass (right) 1.5 6.2 9.1 1.0 -2.9 -3.0
Trunk predicted mass 0.6 3.3 6.6 1.6 -2.6 0.8
Standing height 0.2 1.6 3.1 1.8 -0.7 1.1
Length of working week for main job 0.3 0.3 0.6 -0.5 0.3 0.7
Exposure to tobacco smoke at home 1.3 1.5 4.4 -0.0 -2.1 -0.3
Breastfed as a baby 0.8 1.0 2.5 1.6 0.2 -0.7
Tense / ‘highly strung’ 0.3 0.4 1.1 0.3 0.2 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.7 -1.3 -1.3 0.1
Hair/balding pattern: Pattern 4 0.3 0.7 1.0 -1.0 0.5 -0.8
Birth weight of first child 0.5 0.8 2.4 -0.4 -0.0 1.6
Peak expiratory flow (PEF) 0.3 0.7 1.9 -0.1 -1.4 -0.5
Pulse wave reflection index 0.8 0.9 2.6 -1.6 -0.3 0.3
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.4 -0.1 -0.6 0.1
Loud music exposure frequency 0.6 0.6 1.0 0.5 1.0 -0.8
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.1 0.3 -0.0 0.2
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.3 1.1 -0.7 0.9
Blood clot in the leg (DVT) 0.2 0.2 0.3 0.4 -0.3 0.6
Medication: Paracetamol 1.1 1.8 1.9 -1.4 -1.4 1.2
Headache pain in last month 0.7 1.2 2.7 -1.6 -1.0 -0.0
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.8 -0.3 0.9 -0.2
Glaucoma (self-reported) 5.5 6.5 12.5 -2.5 -3.5 0.8
Gout (self-reported) 0.2 0.3 0.4 -0.6 -0.2 -0.6
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 6.8 -2.6 0.0 1.1
Medication: Amlodipine 3.5 5.0 6.3 -2.5 -2.0 2.2
Medication: Ventolin 100micrograms inhaler 2.1 2.7 6.0 -2.5 0.2 1.5
Birth weight 1.4 3.0 8.4 0.3 -2.9 0.6
Chronic bronchitis/emphysema (mother) 1.8 2.1 3.5 -1.9 -0.7 -1.5
High blood pressure (siblings) 1.0 1.4 4.1 -0.3 -0.2 2.0
Forced vital capacity (FVC), Best measure 0.8 3.0 6.9 -2.6 -1.4 0.3
Body fat percentage 1.2 4.9 8.6 0.5 -2.4 -2.9
Leg fat percentage (right) 1.0 3.5 4.7 0.9 -2.2 -2.2
Arm fat-free mass (right) 0.8 4.0 9.8 1.2 -3.1 0.8
Exposure to tobacco smoke outside home 0.5 0.7 1.7 -1.3 -0.0 -0.5
Comparative body size at age 10 1.0 2.8 7.2 0.2 -2.7 -1.0
Number of full brothers 4.0 5.0 10.9 -3.3 -1.6 1.3
Worry too long after embarrassment 1.2 2.1 3.7 -1.9 -1.3 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.3 -1.1 -0.4 -0.0
Wheeze or whistling in the chest in last year 2.0 3.5 6.1 -2.5 -1.7 1.3
Number of children fathered 0.1 0.1 0.4 0.7 0.0 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.6 -1.0 0.1 1.6
Age at first live birth 0.6 1.1 2.7 1.6 -0.6 -0.3
Pulse wave peak to peak time 0.5 0.6 1.0 1.0 -1.0 0.2
Health satisfaction 0.4 0.5 1.0 0.8 0.1 1.0
Shortness of breath walking on level ground 0.4 0.5 1.2 1.1 0.4 0.5
Qualifications: College or University degree 1.1 3.6 6.8 1.7 2.6 1.2
Eye problems/disorders: None of the above 2.5 2.9 4.4 2.1 2.1 -0.4
Mouth/teeth dental problems: Loose teeth 1.5 1.8 3.8 -0.7 -1.0 1.9
Emphysema/chronic bronchitis 1.8 2.0 5.6 -2.4 0.2 -0.7
Medication for pain relief, constipation, heartburn 0.3 0.6 1.7 0.1 0.3 -1.3
Neck or shoulder pain in last month 0.6 0.8 1.3 -1.1 -0.7 0.7
Medication: Blood pressure 1.3 2.3 5.7 -0.4 -2.4 1.0
Angina (self-reported) 0.3 0.5 0.8 -0.9 0.7 0.3
Migraine (self-reported) 0.5 0.7 1.0 -0.7 -1.0 -0.8
Medication: Ibuprofen 1.0 1.2 1.7 1.3 -1.2 -0.7
Medication: Allopurinol 0.5 0.6 1.3 -0.7 -1.1 -0.2
Medication: Omeprazole 0.9 1.1 1.4 -1.2 1.0 0.9
Medication: Seretide 50 evohaler 2.7 3.1 6.4 -2.5 -1.7 0.2
Mean time to correctly identify matches 0.5 0.9 1.5 0.9 0.7 1.2
Heart disease (mother) 0.5 0.7 1.0 -0.8 -1.0 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 1.7 -1.0 -1.3 -1.2
Whole body fat mass 1.2 5.1 8.8 0.9 -3.0 -2.4
Leg fat mass (right) 1.0 4.0 6.5 1.2 -2.5 -2.0
Arm predicted mass (right) 0.8 4.0 8.9 1.3 -3.0 1.1
Pulse rate, automated reading 0.5 1.6 2.2 0.9 1.3 -1.5
Alcohol intake frequency. 0.4 1.0 1.9 -1.4 0.9 -0.4
Comparative height size at age 10 0.1 0.6 1.7 0.4 -1.3 -0.3
Number of full sisters 0.8 0.9 1.7 -1.3 1.0 0.2
Suffer from ‘nerves’ 1.7 2.6 7.3 -0.7 0.1 2.7
Overall health rating 1.4 3.1 5.1 -1.6 -1.3 2.2
Chest pain or discomfort 0.2 0.2 0.7 0.0 -0.0 0.8
Had major operations 0.3 0.3 0.8 0.2 0.4 0.9
Age at last live birth 0.9 1.3 2.4 1.6 -1.2 0.0
Family relationship satisfaction 0.4 0.5 0.6 0.8 -0.8 -0.6
Leg pain on walking 0.2 0.2 0.7 -0.8 -0.2 0.1
Qualifications: NVQ or HND or HNC or equivalent 2.2 2.7 5.3 -0.9 -2.3 -1.4
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.5 0.5 0.7 0.7
Illness, injury, bereavement, stress in last 2 years 1.9 2.4 4.3 -0.9 -1.4 2.1
Medication: Aspirin 0.4 0.5 1.1 1.1 0.1 0.5
Supplements: Vitamin C 0.6 0.7 1.8 1.3 0.2 -0.4
Knee pain experienced in last month 0.4 0.7 2.0 0.0 -1.4 0.2
Hypertension (Self-reported) 1.0 2.9 5.0 -0.0 -2.2 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.4 7.1 0.0 2.7 0.2
Illnesses of father: Heart disease 0.2 0.3 0.7 0.1 0.1 0.9
Illnesses of siblings: Diabetes 1.7 2.1 3.4 -1.7 -0.6 1.8
Smoking status: Previous 0.3 0.4 0.6 0.7 0.4 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 4.3 0.1 -2.1 -1.2
Whole body fat-free mass 0.7 3.8 9.9 1.2 -3.1 0.4
Leg fat-free mass (right) 1.0 5.5 16.2 0.2 -4.0 -0.4
Arm fat percentage (left) 1.8 7.4 15.3 0.4 -2.6 -3.9
Average weekly red wine intake 0.5 0.8 2.3 0.0 -0.1 1.5
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 0.2 -0.4 0.4
Mood swings 0.2 0.4 0.6 -0.5 -0.8 0.5
Loneliness, isolation 0.3 0.5 1.3 1.1 0.3 -0.1
Long-standing illness, disability or infirmity 0.8 1.2 1.9 -1.3 -1.4 -0.4
Ever had bowel cancer screening 0.7 0.9 2.3 -1.5 0.5 0.3
Diabetes diagnosed by doctor 0.1 0.2 0.4 0.2 0.6 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.0 -1.0 0.1 -0.9
Friendships satisfaction 0.9 1.2 1.3 1.1 1.1 -1.0
Qualifications: nursing, teaching 1.6 2.4 4.9 2.2 1.3 -0.8
Commuting to job workplace: Walk 0.2 0.3 0.6 -0.8 0.4 0.1
Eye problems/disorders: Cataract 1.0 1.2 2.8 -1.7 -0.9 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.3 -0.0 1.5 0.4
Medication for cholesterol 0.8 1.2 3.3 -0.6 -0.1 -1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.6 -0.8 -0.1 0.1
Back pain experienced in last month 1.1 1.6 4.4 2.1 0.4 -0.6
Mineral and other dietary supplements 1.7 2.3 4.0 -2.0 -1.7 -0.2
Breast cancer (self-reported) 1.6 1.9 2.5 1.6 1.3 -1.2
Asthma (self-reported) 3.3 6.5 10.9 -3.3 -2.6 1.3
Osteoporosis (self-reported) 0.6 0.8 1.4 -0.5 0.8 1.2
Osteoarthritis (self-reported) 0.6 0.8 1.5 -1.2 -0.7 0.7
Medication: Aspirin 0.4 0.5 1.1 1.0 0.0 0.7
Medication: Gliclazide 1.1 1.2 2.5 -0.4 -1.0 -1.6
Illnesses of father: None of the above (group 1) 0.8 1.0 2.1 -0.5 -1.5 0.7
Smoking status: Current 0.7 1.1 1.9 -1.1 0.2 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 6.4 -2.5 -1.8 -0.3
Whole body water mass 0.7 3.9 10.0 1.2 -3.2 0.4
Leg predicted mass (right) 1.0 5.4 16.2 0.2 -4.0 -0.4
Arm fat mass (left) 1.5 6.1 8.9 1.1 -2.9 -3.0
Number of self-reported non-cancer illnesses 1.4 2.4 4.5 -2.1 -0.9 1.4
Average weekly champagne plus white wine intake 0.9 1.2 2.6 1.6 0.7 0.7
Miserableness 0.3 0.6 1.3 -1.1 -0.4 0.5
Guilty feelings 1.9 2.8 5.2 -1.5 -1.0 2.3
Wears glasses or contact lenses 0.4 0.5 0.7 -0.6 -0.6 0.9
Ever taken oral contraceptive pill 0.7 0.8 2.2 -0.4 -0.3 -1.5
Hearing aid user 2.5 2.8 7.5 2.7 0.9 -0.4
Mother’s age at death 0.6 0.8 1.7 0.7 0.3 1.3
Financial situation satisfaction 1.0 1.3 3.1 -1.8 0.8 0.4
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 0.3 -0.4 -0.3
Commuting to job workplace: Public transport 2.6 3.1 7.3 -2.7 0.6 1.3
Eye problems/disorders: Glaucoma 6.3 7.5 15.1 -2.7 -3.9 0.5
Medication: Blood pressure 0.8 1.5 3.2 0.9 -0.6 1.8
Pain type(s) experienced in last month: Hip pain 1.0 1.2 1.9 -1.4 -0.6 -1.2
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.9 1.7 1.1 -0.3
High cholesterol (Self-reported) 1.0 1.7 3.3 1.3 1.8 0.2
Medication: Bendroflumethiazide 2.1 3.2 9.3 3.1 -0.3 -0.2
Medication: Paracetamol 0.7 1.1 1.8 -1.4 -0.8 0.9
Medication: Lisinopril 1.0 1.2 2.0 1.4 -0.1 -1.3
Medication: Atorvastatin 0.6 0.8 1.8 1.3 -0.4 -0.7
Illnesses of father: High blood pressure 1.2 1.4 1.8 -1.1 -1.4 1.1
Alcohol drinker status: Never 1.4 1.7 3.3 1.0 1.8 0.8
Ever smoked 0.0 0.0 0.1 -0.2 -0.1 0.1
Basal metabolic rate 0.8 4.3 10.9 1.3 -3.3 -0.2
Leg fat percentage (left) 1.1 3.9 7.5 0.9 -2.7 -1.8
Arm fat-free mass (left) 0.7 3.8 8.6 1.6 -2.9 0.5
Number of operations (self-reported) 0.5 0.7 1.7 0.2 -1.3 0.7
Average weekly beer plus cider intake 0.6 0.9 1.5 1.2 -0.4 -0.9
Irritability 0.5 0.8 2.0 -0.5 0.3 1.4
Risk taking 0.4 0.6 0.8 0.9 0.8 0.7
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.0 1.0 0.4 -0.3
Fractured/broken bones in last 5 years 0.1 0.1 0.1 0.4 -0.4 0.1
Age started oral contraceptive pill 0.1 0.1 0.3 0.2 0.1 0.6
Diastolic blood pressure, automated reading 0.4 1.3 1.9 1.4 -0.7 -1.2
Ever depressed for a whole week 1.2 1.4 2.7 -0.5 1.2 1.6
Unable to work because of sickness or disability 1.1 1.4 2.3 -1.5 -0.2 1.4
Commuting to job workplace: Cycle 1.1 1.3 1.9 1.4 1.2 -0.8
Myopia 0.7 1.0 1.6 -1.3 0.3 1.1
Vascular/heart problems diagnosed by doctor 1.1 3.1 4.6 0.6 2.1 -2.1
Cholesterol lowering medication 0.4 0.6 1.3 0.8 1.1 0.2
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.1 -1.4 0.7 0.7
Pain experienced in last month 0.4 0.7 2.2 -0.2 1.5 -0.2
Supplements: Calcium 0.5 0.5 1.3 0.4 0.3 1.2
Basal cell carcinoma (self-reported) 0.2 0.2 0.7 0.1 0.1 0.8
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.0 -0.1 0.2 0.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.5 0.5 -0.4 0.7
Heart disease (siblings) 0.6 0.7 1.6 -1.3 -0.3 0.7
Alcohol drinker status: Previous 2.8 3.2 9.7 -3.1 0.1 0.0
Pack years of smoking 0.9 1.3 3.3 0.8 -0.2 -1.8
Impedance of whole body 0.5 2.4 5.7 -0.2 2.4 -1.2
Leg fat mass (left) 1.1 4.3 8.2 1.2 -2.9 -1.8
Arm predicted mass (left) 0.8 4.1 8.8 1.8 -3.0 0.4