TWAS hub - EXT1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1130	0.0410	3.3e-03	-0.001	NA	0.016	NA	-0.002	4.2e-01	NA	2.2e-02	NA	4.9e-01
2	METSIM	Adipose	0.0814	0.0221	5.3e-07	0.081	0.039	0.057	0.062	0.074	3.5e-12	1.3e-06	6.9e-09	1.2e-09	3.7e-11
3	YFS	Blood	0.0729	0.0159	2.1e-13	0.031	0.047	0.061	0.053	0.055	2.0e-10	3.6e-15	2.3e-19	6.0e-17	1.8e-17
4	TCGA	Lung Squamous Cell Carcinoma	0.0489	0.0217	6.7e-04	0.008	0.007	0.004	NA	0.002	4.0e-02	4.5e-02	9.3e-02	NA	1.7e-01
5	TCGA	Pancreatic Adenocarcinoma	0.2320	0.0950	4.9e-03	-0.001	0.014	0.010	NA	0.017	3.8e-01	7.9e-02	1.2e-01	NA	6.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Seen doctor (GP) for nerves, anxiety, tension or depression	3.9	6.0	13.8	-2.3	-0.9	-3.7	-0.5	3.2
Reaction Time	3.3	6.2	20.3	-0.6	-1.9	2.6	4.5	0.1
Verbal and Numeric Reasoning (VNR)	3.3	8.0	16.9	-2.1	-0.8	-4.0	-4.1	1.5
Number of incorrect matches in round	3.3	5.4	22.8	-0.3	-1.3	1.6	4.8	0.4
Fluid intelligence score	3.3	6.8	15.0	-2.6	0.2	-3.4	-3.9	0.8
Qualifications: College or University degree	3.2	10.0	27.3	-0.0	0.9	-4.6	-5.2	1.0
Mean time to correctly identify matches	3.2	6.1	16.6	-1.5	-2.6	2.1	4.1	0.8
Medication: Seretide 50 evohaler	3.0	3.4	9.9	-0.6	-3.1	1.0	1.2	-2.1
Intelligence (Savage-Jansen 2018)	2.9	8.8	18.2	-1.4	-0.9	-4.3	-4.0	2.6
BMI	2.8	16.5	40.7	4.5	1.8	2.9	-3.1	-6.4
Diabetes (self-reported)	2.8	4.3	12.3	1.8	-1.7	1.7	3.5	-0.3
Type 2 Diabetes (T2D) (2018)	2.7	5.1	11.4	2.2	-1.5	2.5	3.4	-0.9
Multivitamins +/- minerals	2.7	3.4	7.0	2.0	-2.6	1.2	0.6	-2.1
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	6.4	-0.2	2.3	-1.6	-2.5	-1.1
Average weekly spirits intake	2.6	3.2	9.1	0.0	1.0	1.1	-3.0	-2.2
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.2	7.2	0.8	0.5	2.7	2.3	-1.6
Diabetes diagnosed by doctor	2.6	4.2	11.1	1.2	-2.1	2.0	3.3	0.0
Illnesses of mother	2.5	3.1	12.3	-0.3	3.5	0.9	-1.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	10.0	3.2	1.4	0.7	0.4	-1.6
Age started oral contraceptive pill	2.5	3.1	11.9	-0.6	1.2	-1.4	-3.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	3.0	12.2	-1.3	-0.0	-0.9	0.6	3.5
Number of children fathered	2.3	2.6	6.3	0.1	-0.3	-2.1	-2.5	-1.5
Age at last live birth	2.3	3.3	7.3	-2.7	0.8	-2.3	-1.7	0.8
Ever depressed for a whole week	2.3	2.8	4.1	-2.0	-1.5	-2.0	0.4	1.9
Qualifications: None of the above	2.2	4.8	13.5	-0.3	-1.4	2.9	3.7	-0.3
Comparative body size at age 10	2.2	6.0	16.0	2.8	0.7	2.4	-0.2	-4.0
Ever had prostate specific antigen (PSA) test	2.2	2.5	6.0	-0.8	-2.5	-0.7	1.1	2.0
Bipolar Disorder (2011)	2.1	2.0	4.0	-1.6	-1.0	-1.5	0.6	2.0
Loud music exposure frequency	2.1	2.3	5.9	-2.4	0.6	-1.7	0.3	1.4
Heart disease (mother)	2.1	2.5	6.0	-0.8	-2.5	-1.6	0.6	1.7
Smoking status: Previous	2.1	3.1	7.7	-0.1	-2.5	1.0	2.8	-0.8
Alzheimer’s Disease (in father)	2.0	2.2	5.9	-1.6	0.3	-2.4	-1.2	0.9
Qualifications: A levels/AS levels or equivalent	2.0	4.5	13.2	-0.2	1.4	-2.6	-3.6	0.9
Tense / ‘highly strung’	2.0	3.3	7.2	-2.7	-1.7	-1.3	1.9	1.1
Severe depression (siblings)	1.9	2.1	4.3	-1.3	1.8	2.1	1.1	0.5
Body mass index (BMI)	1.9	8.2	19.9	2.9	1.6	2.5	-2.0	-4.5
Father’s age at death	1.9	2.5	5.7	0.5	-2.4	-0.9	-1.6	-1.8
Migraine (self-reported)	1.9	2.4	3.3	-0.9	-1.4	-1.8	1.8	1.5
Long-standing illness, disability or infirmity	1.9	3.0	9.7	-3.1	1.0	-1.4	-1.0	1.0
Qualifications: nursing, teaching	1.9	3.0	8.9	-1.1	-0.4	-2.1	-3.0	0.5
Medication: Gliclazide	1.9	2.1	4.2	0.8	-1.4	2.1	1.8	-0.7
Worry (Nagel 2018)	1.8	3.8	7.8	-2.4	-2.2	-0.8	2.8	-0.1
Alzheimer’s Disease (including proxy)	1.8	2.6	5.3	-0.9	1.5	-1.8	-1.0	2.3
Rheumatoid Arthritis	1.8	2.5	6.3	1.6	-0.5	1.7	0.6	-2.5
Hearing difficulty/problems: Yes	1.8	2.7	7.5	-2.2	-2.7	0.7	-0.1	-0.8
Vitamin and mineral supplements	1.8	2.5	6.4	-1.2	2.5	-0.4	-1.5	1.5
Maternal smoking around birth	1.8	2.6	5.9	-0.6	-1.0	2.4	2.1	-1.1
Impedance of leg (left)	1.8	8.7	15.9	-3.4	-3.1	-1.9	1.5	4.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.2	5.2	1.3	-0.5	2.3	1.5	-1.2
Arm fat mass (left)	1.8	7.5	20.6	3.0	0.3	2.1	-2.0	-4.5
Lupus	1.7	2.6	7.9	1.6	0.6	0.7	-1.2	-2.8
Hair/balding pattern: Pattern 2	1.7	2.2	6.3	-1.5	0.9	-1.3	-0.1	2.5
Arm fat mass (right)	1.7	7.1	18.1	3.1	0.7	2.0	-1.9	-4.3
Ever taken oral contraceptive pill	1.7	1.9	4.8	2.2	-0.7	1.2	1.2	-1.1
Prostate Cancer	1.6	2.2	4.9	0.7	1.1	-2.0	-0.6	2.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	5.4	-2.3	1.2	-0.8	-1.5	0.4
Guilty feelings	1.6	2.5	8.8	-3.0	0.4	-0.6	-0.5	1.6
Medication: Bendroflumethiazide	1.6	2.5	5.9	1.8	-0.5	2.4	1.0	-1.4
Unable to work because of sickness or disability	1.6	2.1	5.5	1.6	2.3	1.0	-0.7	-1.0
Mean Putamen Volume	1.5	1.8	6.8	-0.0	0.8	-0.5	-2.6	-1.0
Waist circumference	1.5	5.4	12.8	2.8	0.2	1.4	-2.0	-3.6
Past tobacco smoking	1.5	2.8	6.9	1.1	2.4	-0.6	-2.6	0.1
Nervous feelings	1.5	2.7	5.8	-2.4	-1.9	-1.5	1.5	0.2
Hip circumference	1.5	6.4	12.7	3.4	1.0	1.0	-2.4	-3.6
Gout (self-reported)	1.5	2.0	3.0	0.2	1.2	1.7	-1.6	-1.7
Leg fat mass (right)	1.5	5.9	14.9	2.6	0.5	2.0	-1.8	-3.9
Arm fat percentage (left)	1.5	6.0	14.9	2.6	0.4	2.7	-0.9	-3.9
Commuting to job workplace: Public transport	1.5	1.7	2.8	-0.9	1.6	-1.5	-1.7	0.4
Breast Cancer	1.4	3.4	7.0	1.1	-1.3	2.4	2.6	-1.1
LDL Cholesterol	1.4	2.2	7.1	-0.6	-0.4	-2.7	-0.9	1.7
Type 2 Diabetes (T2D) (2012)	1.4	1.7	2.5	1.1	-1.1	1.6	1.1	-1.5
Ever used hormone-replacement therapy (HRT)	1.4	1.7	3.2	1.1	-1.2	1.8	-0.2	-1.7
Medication: Metformin	1.4	1.9	4.5	0.3	-0.2	2.0	2.1	-0.9
Impedance of leg (right)	1.4	6.7	13.0	-3.6	-2.2	-1.4	0.9	3.6
Average weekly fortified wine intake	1.4	1.6	3.9	-0.8	-1.8	2.0	0.3	0.1
Weight	1.4	6.7	17.1	3.1	0.2	0.8	-2.5	-4.1
Arm fat percentage (right)	1.4	5.6	11.8	2.8	0.6	2.8	-0.8	-3.4
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.0	-1.3	-0.6	1.6	0.7	-2.0
Age at first live birth	1.4	2.4	5.8	-0.8	-0.6	-2.4	-2.1	0.9
Pulse wave peak to peak time	1.4	1.7	4.5	-0.2	-2.1	-1.4	1.3	0.7
Number of full sisters	1.4	1.7	6.6	-2.6	1.3	0.1	-0.2	0.4
Friendships satisfaction	1.4	1.7	3.5	-1.5	-0.7	-1.4	-1.9	-0.3
Mineral and other dietary supplements	1.4	1.9	6.8	-0.2	0.3	-1.5	-2.6	0.0
Leg fat mass (left)	1.4	5.5	14.3	2.6	0.3	1.8	-1.7	-3.8
Medication: Atenolol	1.3	1.6	4.9	-0.9	-0.4	1.5	2.2	-0.2
Leg predicted mass (left)	1.3	6.7	18.0	3.3	0.6	0.7	-1.9	-4.2
Neuroticism score	1.3	2.7	5.2	-2.3	-0.1	-1.0	1.7	2.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	6.2	0.0	0.2	-2.5	-2.0	0.7
Birth weight	1.3	2.8	8.1	2.0	0.0	-0.7	-2.8	-1.2
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.6	0.3	-1.4	0.8	0.5	-2.1
Illnesses of father: Heart disease	1.3	1.8	6.6	-2.6	-0.8	0.0	0.8	1.1
Ever had bowel cancer screening	1.3	1.6	4.0	-0.9	-2.0	-0.3	0.5	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.5	0.2	1.0	0.2	2.1	-1.3
Back pain experienced in last month	1.3	1.9	6.2	0.7	-0.5	1.5	0.3	-2.5
Commuting to job workplace: Cycle	1.3	1.6	5.5	-2.3	-0.1	-0.9	-0.9	0.9
Major Depression (MDD)	1.2	1.4	5.1	0.5	0.5	-2.3	-0.4	1.2
Coronary Artery Disease (CAD)	1.2	1.4	6.6	0.2	2.6	0.4	0.2	0.2
Neuroticism	1.2	3.0	5.0	-1.7	-0.8	-1.8	1.7	2.2
Diabetes (mother)	1.2	1.5	3.5	-1.2	-1.5	0.5	1.9	-0.5
Leg fat-free mass (left)	1.2	6.5	17.4	3.3	0.5	0.8	-1.9	-4.2
Qualifications: CSEs or equivalent	1.2	1.6	3.2	1.8	-0.6	1.0	1.7	-0.6
High blood pressure	1.2	3.3	11.6	-0.1	-0.2	3.4	0.7	-2.1
Trunk fat mass	1.2	5.0	13.9	2.3	-1.1	1.4	-1.6	-3.7
Mouth/teeth dental problems	1.2	1.8	5.4	0.9	-0.1	-2.3	-1.3	1.1
Prospective memory result	1.2	1.4	4.3	-0.7	-1.0	0.8	2.1	0.9
Whole body fat mass	1.2	5.2	14.6	2.3	-0.4	1.6	-1.8	-3.8
Overall health rating	1.2	2.6	4.5	-2.1	-1.3	-2.1	-0.5	1.3
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.8	-0.7	-0.6	-0.3	-2.2	-1.1
Arm fat-free mass (left)	1.2	6.1	15.3	3.0	0.4	0.0	-2.5	-3.9
Alcohol drinker status: Previous	1.2	1.3	4.5	-0.7	0.6	0.7	2.1	0.9
Impedance of whole body	1.2	6.1	12.2	-2.6	-2.6	-1.5	1.5	3.5
Angina	1.1	1.4	2.6	-0.1	1.6	1.1	-1.1	-1.4
Taking other prescription medications	1.1	1.7	3.3	0.0	-1.2	1.1	1.7	1.8
Serious illness, injury or assault to yourself	1.1	1.4	3.0	0.4	-1.5	-1.3	-1.7	0.0
Alcohol intake versus 10 years previously	1.1	1.7	5.5	-0.5	0.1	2.3	1.3	-1.0
Happiness	1.1	1.3	2.9	-1.7	0.4	1.3	1.2	0.1
Pulse wave Arterial Stiffness index	1.1	1.3	3.2	0.1	1.8	1.2	-1.3	-0.6
Exposure to tobacco smoke at home	1.1	1.2	2.6	-1.6	1.4	0.6	0.8	0.4
Birth weight of first child	1.1	1.9	8.9	0.2	0.4	-0.8	-3.0	0.3
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.6	0.8	-1.1	1.2	0.3	-1.9
Angina (self-reported)	1.1	1.5	3.2	0.1	1.8	1.0	-1.0	-1.4
Arm predicted mass (right)	1.1	5.5	15.9	2.6	0.3	-0.3	-2.1	-4.0
Chest pain or discomfort	1.1	1.6	6.5	-2.5	-0.5	-1.1	0.4	-0.4
Leg fat-free mass (right)	1.1	6.0	16.0	3.3	0.3	0.3	-1.6	-4.0
Whole body water mass	1.1	6.3	16.2	3.3	0.3	-0.2	-2.1	-4.0
Leg predicted mass (right)	1.1	5.7	15.0	3.3	0.2	0.3	-1.6	-3.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.8	-0.9	-1.7	-0.7	0.2	1.5
Alcohol drinker status: Never	1.1	1.3	2.6	-1.4	0.2	-1.0	1.0	1.6
Basal metabolic rate	1.1	6.3	16.3	3.2	0.2	0.0	-2.2	-4.0
Irritability	1.1	1.8	3.3	-1.8	1.2	-1.4	-0.3	1.5
Myopia	1.1	1.6	3.5	-0.5	-1.9	0.8	1.8	0.0
Vascular/heart problems diagnosed by doctor	1.1	3.1	11.5	0.0	0.0	-3.4	-0.4	2.0
Arm predicted mass (left)	1.1	5.7	13.9	3.0	0.4	0.2	-2.3	-3.7
Alzheimer’s Disease (in mother)	1.0	1.1	4.0	0.4	0.4	-1.1	-0.4	2.0
Smoking Status	1.0	2.4	5.5	0.2	-1.5	2.0	2.3	0.3
Pain all over the body in last month	1.0	1.1	2.4	-0.0	0.5	-1.4	-1.5	-1.0
Impedance of arm (right)	1.0	4.8	11.9	-1.9	-2.2	-1.3	1.5	3.5
Time employed in main current job	1.0	1.2	2.4	-1.5	0.5	-1.3	0.4	1.1
Medication: Lansoprazole	1.0	1.1	2.6	0.8	0.2	1.5	1.6	-0.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.9	-0.0	0.6	-2.2	-1.4	0.8
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.3	0.6	-1.5	0.7	1.4	-0.7
Body fat percentage	1.0	3.8	9.4	1.9	-0.7	2.1	-1.0	-3.1
Arm fat-free mass (right)	1.0	5.3	14.9	2.5	0.2	-0.1	-2.3	-3.9
Suffer from ‘nerves’	1.0	1.5	5.7	-1.0	-0.8	0.3	2.4	0.6
Hypertension (Self-reported)	1.0	2.8	10.1	-0.1	-0.3	3.2	1.1	-1.7
Whole body fat-free mass	1.0	5.8	15.5	3.1	0.2	-0.1	-2.0	-3.9
Number of self-reported non-cancer illnesses	1.0	1.8	4.1	-0.9	-2.0	1.2	1.5	0.3
Supplements: Fish oil (including cod liver oil)	1.0	1.3	5.1	-0.4	-0.2	1.1	2.3	0.1
Risk taking	1.0	1.5	2.8	1.7	1.2	1.3	-0.5	-1.1
Neuroticism (Nagel 2018)	0.9	2.1	3.5	-1.9	-0.6	-1.8	1.3	1.4
Age at First Birth	0.9	1.4	4.4	0.4	-0.6	-1.1	-0.9	2.1
Lung FEV1/FVC ratio	0.9	4.6	12.7	-2.1	-0.5	-3.6	-0.0	2.4
Trunk fat percentage	0.9	3.6	9.6	1.7	-1.2	1.8	-1.1	-3.1
Noisy workplace	0.9	1.1	4.1	-1.0	-2.0	-0.2	0.4	-0.0
Impedance of arm (left)	0.9	3.9	7.9	-1.9	-2.2	-1.1	1.4	2.8
Leg fat percentage (right)	0.9	3.4	6.5	1.6	1.0	2.3	-1.3	-2.5
Medication: Blood pressure	0.9	1.7	6.5	0.6	0.2	2.5	0.7	-1.0
Supplements: Vitamin C	0.9	1.1	2.1	-1.5	0.8	-1.4	0.7	-0.3
Smoking status: Current	0.9	1.4	2.8	-0.3	1.0	1.4	1.1	1.7
Medication: Lisinopril	0.9	1.2	3.4	0.6	0.7	-0.8	-1.8	-1.0
Illnesses of father: High blood pressure	0.9	1.1	4.4	0.8	-0.6	-0.2	2.1	0.3
Number of operations (self-reported)	0.9	1.3	3.7	0.1	-0.7	1.5	1.9	-0.1
Heel T-Score	0.8	6.2	13.1	-1.0	-1.4	3.6	2.9	-2.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.0	0.8	1.4	1.0	-0.4	-0.5
Current tobacco smoking	0.8	1.3	2.2	-0.3	1.1	1.5	0.9	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	3.6	-1.9	-0.6	-1.2	0.5	0.6
Financial difficulties in last 2 years	0.8	1.1	3.8	-0.1	0.7	1.9	1.0	-0.6
Trunk fat-free mass	0.8	4.7	11.4	2.8	0.0	-0.7	-2.0	-3.4
Worrier / anxious feelings	0.8	1.6	4.9	-1.4	-0.3	0.9	2.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	8.8	0.2	-1.9	-3.0	0.3	1.0
Mouth/teeth dental problems: Dentures	0.8	1.3	3.1	0.5	1.3	1.8	0.9	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	6.7	-0.0	-1.7	-2.6	1.0	1.1
Trunk predicted mass	0.8	4.7	11.7	2.8	0.0	-0.6	-1.9	-3.4
Pulse rate, automated reading	0.8	2.5	7.7	-0.2	1.9	-0.2	-2.8	1.1
Average weekly red wine intake	0.8	1.2	4.0	0.6	-1.3	-2.0	-0.4	0.2
Eye problems/disorders: Glaucoma	0.8	0.9	3.7	-0.1	1.9	-0.4	-0.9	-0.1
Ever smoked	0.8	1.3	2.8	-0.8	-1.7	0.4	1.6	-0.7
Leg fat percentage (left)	0.8	2.9	5.9	1.8	0.5	2.0	-1.0	-2.4
Supplements: Calcium	0.8	0.9	3.8	-1.9	-0.1	-0.0	-0.8	0.4
HDL Cholesterol	0.7	1.2	4.6	2.1	0.8	0.2	0.3	0.8
Waist Hip Ratio (WHR)	0.7	3.1	10.8	-0.5	-3.3	-1.8	-0.7	0.5
Stomach or abdominal pain in last month	0.7	0.8	2.6	-1.6	-0.3	0.9	0.5	0.8
Had other major operations	0.7	0.8	2.8	0.2	-0.3	0.2	1.0	1.7
Forced vital capacity (FVC)	0.7	2.8	7.2	0.4	-2.7	-2.3	0.7	0.9
Pulse rate	0.7	1.1	1.9	-1.0	1.4	-0.3	-1.2	1.2
Medication: Cholesterol lowering	0.7	1.1	3.5	0.0	-0.9	1.9	1.1	-0.0
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.1	-0.2	1.4	1.5	0.5	-0.3
Medication: Amlodipine	0.7	0.9	2.9	0.0	-0.1	1.7	0.7	-1.1
Forced vital capacity (FVC), Best measure	0.7	2.4	4.6	0.1	-2.1	-1.9	1.3	1.5
Worry too long after embarrassment	0.7	1.2	2.4	-0.9	-1.1	-1.6	0.4	1.2
Neck or shoulder pain in last month	0.7	1.0	1.8	-1.3	-1.4	0.2	0.2	-1.3
Family relationship satisfaction	0.7	0.9	1.8	-0.9	0.6	-1.2	-1.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	2.5	-1.4	0.0	-0.2	0.8	1.6
Wears glasses or contact lenses	0.7	0.8	1.8	-0.9	-0.9	0.8	-0.4	-1.3
Fractured/broken bones in last 5 years	0.7	0.9	1.8	0.3	1.3	1.4	0.5	0.7
Depressed Affect (Nagel 2018)	0.6	1.2	2.8	-0.8	0.6	-1.7	-0.0	1.5
Fasting Glucose	0.6	0.8	2.1	-1.4	0.2	0.1	0.9	1.0
Primary Biliary Cirrhosis	0.6	0.9	1.8	1.3	0.6	1.4	-0.2	-0.8
Cardiovascular Disease	0.6	2.0	4.8	-1.1	0.3	2.2	0.1	-1.9
Chronotype (morning person)	0.6	1.3	3.6	0.6	-1.1	0.1	1.2	-1.9
Number of treatments/medications taken	0.6	1.1	1.5	-1.1	-1.1	1.2	1.2	0.7
Ever had hysterectomy (womb removed)	0.6	0.7	2.5	0.7	-0.6	0.2	1.6	0.1
Townsend deprivation index at recruitment	0.6	0.8	2.0	1.0	0.5	1.4	0.5	-0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.8	0.1	0.4	1.7	0.8	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.3	-1.4	-2.1	0.6	0.2	-0.6
High blood pressure (mother)	0.6	0.8	3.4	0.2	-1.8	-0.7	-0.2	-0.5
Had menopause	0.6	0.8	2.4	-1.1	1.5	0.3	-0.3	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.0	-1.7	-1.0	-0.3	0.5	-0.7
Depression (self-reported)	0.6	0.8	1.7	-0.2	-1.2	-1.3	-0.7	0.3
Lung cancer (father)	0.6	0.7	2.2	-0.4	0.1	-1.0	-1.5	-0.0
Standing height	0.6	5.5	13.2	0.7	-3.4	-3.6	-1.5	-0.1
Length of working week for main job	0.6	0.7	2.1	-0.6	-0.4	-1.5	-0.4	-0.8
Glaucoma (self-reported)	0.6	0.7	1.9	-0.9	1.4	-0.5	-0.6	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	0.3	0.3	-1.4	0.6	1.0
Health satisfaction	0.6	0.8	2.9	-1.7	0.5	0.7	-0.5	-0.0
Shortness of breath walking on level ground	0.6	0.7	2.0	-0.1	-1.0	0.3	-0.5	-1.4
Medication for pain relief, constipation, heartburn	0.6	1.0	3.1	0.2	0.1	-1.0	-1.8	-1.0
Medication: Omeprazole	0.6	0.7	2.6	-0.1	1.6	-0.1	0.2	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.0	-0.3	0.6	-0.4	1.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.9	1.7	-1.1	-1.5	0.3	-0.2
Illnesses of father: None of the above (group 1)	0.6	0.7	2.0	1.4	0.7	-0.0	-1.0	-0.1
Financial situation satisfaction	0.6	0.8	1.9	0.4	0.5	-1.2	-1.4	0.2
High cholesterol (Self-reported)	0.6	1.0	3.3	-1.8	-1.2	0.3	0.5	0.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	3.2	0.1	0.4	1.8	-0.2	-0.5
Ovarian Cancer	0.5	0.7	2.2	-0.0	-1.0	0.5	1.5	0.1
Neuroticism (2016)	0.5	0.7	2.4	-0.5	-0.7	-1.5	-0.0	0.5
Triglycerides	0.5	0.9	1.6	1.1	0.3	-1.1	-0.6	1.3
Height	0.5	10.4	33.2	0.4	-5.8	-4.1	-1.2	-0.3
Sensitivity / hurt feelings	0.5	0.9	3.8	0.1	-0.3	0.6	1.9	0.4
Medication for hormone replacement therapy	0.5	0.6	1.6	0.1	-0.7	1.3	0.2	-0.9
Medication: Co-codamol	0.5	0.6	0.9	-0.1	-0.8	-0.8	-0.7	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.8	-0.9	1.3	0.8	0.2	0.2
Supplements: Glucosamine	0.5	0.7	3.0	0.3	-0.3	0.4	1.7	0.2
Hearing difficulty/problems with background noise	0.5	0.8	1.6	-1.3	-1.1	1.0	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.9	-1.2	-1.7	0.6	0.0	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	-1.2	-0.3	-0.6	0.1	1.0
Hair/balding pattern: Pattern 3	0.5	0.8	1.3	-1.1	0.2	-0.9	-0.5	1.1
Peak expiratory flow (PEF)	0.5	1.2	3.1	-1.1	-1.1	-1.8	-0.6	-0.5
Blood clot in the leg (DVT)	0.5	0.6	2.5	0.2	0.2	1.6	-0.3	-0.6
Exposure to tobacco smoke outside home	0.5	0.6	2.0	0.2	-0.4	1.4	0.3	-1.0
Wheeze or whistling in the chest in last year	0.5	0.8	1.8	0.5	0.0	0.7	-1.4	-1.2
Eye problems/disorders: None of the above	0.5	0.6	2.7	-0.2	-1.6	0.2	0.1	0.3
Alcohol intake frequency.	0.5	1.1	2.2	-0.6	1.5	1.1	1.2	-0.1
Leg pain on walking	0.5	0.7	1.3	-0.9	-1.1	0.3	-0.4	-1.1
Loneliness, isolation	0.5	0.7	1.9	-1.0	0.7	-0.3	0.5	1.4
Eye problems/disorders: Cataract	0.5	0.5	2.4	-0.2	-0.4	0.1	-0.3	-1.6
Breast cancer (self-reported)	0.5	0.6	1.4	-0.1	-1.2	1.1	-0.3	-0.5
Osteoarthritis (self-reported)	0.5	0.6	1.4	-0.4	-1.2	-1.1	-0.0	-0.5
Cholesterol lowering medication	0.5	0.7	1.4	-1.2	0.2	0.7	-1.1	-0.8
Pain experienced in last month	0.5	0.8	1.8	-0.1	0.4	-1.0	-1.0	1.4
Basal cell carcinoma (self-reported)	0.5	0.5	1.1	0.9	1.0	0.7	-0.6	-0.3
Heart disease (siblings)	0.5	0.6	1.7	0.5	-1.3	-0.8	-0.4	0.5
HbA1C	0.4	0.4	1.3	0.7	0.4	-0.4	-1.1	0.4
Schizophrenia (2014)	0.4	0.8	2.7	-0.6	-0.8	0.0	1.6	0.7
Ulcerative Colitis	0.4	0.5	0.9	-0.9	-0.2	-0.8	-0.6	0.8
Lung FVC	0.4	1.8	3.9	0.2	0.0	-1.4	1.8	2.0
Fed-up feelings	0.4	0.8	2.1	-0.4	0.8	-0.9	0.5	1.4
Age when periods started (menarche)	0.4	1.1	2.5	0.3	1.4	-1.6	-0.8	0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.3	-0.6	0.1	-0.5	-1.1	-0.7
Alcohol usually taken with meals	0.4	0.6	1.9	-1.1	-1.4	-0.1	-0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.6	-0.5	-1.3	0.0	-0.1	-1.0
Medication: Ramipril	0.4	0.5	1.7	0.4	0.0	0.8	1.3	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.9	-0.0	-0.0	1.4	0.8	0.1
Breastfed as a baby	0.4	0.5	1.6	-0.2	-1.0	0.1	1.3	0.2
Hair/balding pattern: Pattern 4	0.4	0.9	2.3	0.6	-1.5	-1.2	0.1	0.3
Pulse wave reflection index	0.4	0.5	1.4	0.7	-0.3	0.1	-0.7	-1.2
Medication: Ibuprofen	0.4	0.5	2.1	-0.2	-0.1	1.4	0.4	0.6
Medication: Allopurinol	0.4	0.6	2.0	0.3	0.3	0.7	-1.4	-0.3
Comparative height size at age 10	0.4	2.0	4.0	1.2	-2.0	0.0	1.5	-1.6
Mood swings	0.4	0.7	1.2	-1.1	0.8	-1.0	-0.6	0.7
Commuting to job workplace: Walk	0.4	0.4	0.8	-0.5	0.6	0.1	-0.8	-0.9
Hearing aid user	0.4	0.4	1.2	0.5	-0.1	-0.6	-0.5	1.1
Average weekly beer plus cider intake	0.4	0.6	1.8	0.1	-0.7	-0.4	0.6	1.4
Diastolic blood pressure, automated reading	0.4	1.4	3.4	-0.2	-0.2	1.7	-0.7	-1.9
Schizophrenia (2018)	0.3	0.7	2.0	-0.4	-1.0	-0.2	1.4	0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	0.8	0.3	0.7	0.7	-0.4
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	0.3	-0.4	-0.0	-1.0	-0.8
Blood White Count	0.3	1.9	3.0	1.7	-1.1	1.6	0.9	-1.3
Hypothyroidism (self reported)	0.3	0.7	1.5	-0.7	0.1	0.9	1.2	-0.9
Systolic blood pressure, automated reading	0.3	1.0	2.0	0.1	-1.0	1.4	0.5	-1.3
Diabetes (father)	0.3	0.4	1.3	-0.3	1.1	-0.5	-0.2	0.5
Relative age voice broke	0.3	0.5	1.5	-0.8	0.4	-0.5	-0.3	1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	-0.8	-0.2	-0.4	-0.7	0.8
Medication: Levothyroxine sodium	0.3	0.6	1.9	-1.4	0.8	0.2	0.6	0.2
Allergy	0.3	0.6	2.6	-0.6	0.1	-0.2	-0.2	1.6
Medication: Simvastatin	0.3	0.4	0.8	0.0	-0.7	0.9	-0.7	0.1
Number of live births	0.3	0.4	1.3	-0.1	0.8	-0.0	-0.5	-1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.8	-1.7	0.1	0.1	0.4	0.3
High blood pressure (siblings)	0.3	0.4	0.9	-0.9	-0.4	0.2	-0.1	-0.9
Number of full brothers	0.3	0.4	1.1	0.4	0.8	-0.4	1.0	0.2
Had major operations	0.3	0.3	1.2	0.4	-0.0	0.4	1.1	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	-0.4	-0.5	-0.5	-0.8	-0.8
Asthma (self-reported)	0.3	0.6	2.0	0.5	-0.1	1.4	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.3	0.9	-1.5	-0.5	0.4	0.0
Medication: Atorvastatin	0.3	0.3	0.7	-0.7	0.5	0.4	-0.8	0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	-0.5	1.0	0.2	0.7	0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	-0.6	-1.0	-0.5	0.7	0.5
Crohns Disease (2017)	0.2	0.4	1.5	0.3	-0.5	-0.0	-1.2	0.4
Ulcerative Colitis (UC)	0.2	0.5	0.7	-0.8	-0.8	0.4	0.5	0.7
Systolic Blood Pressure	0.2	0.8	1.7	0.4	-1.0	1.3	0.8	-0.7
Allergy or Eczema	0.2	0.5	1.1	1.1	0.8	-0.6	-0.4	-0.7
Respiratory disease	0.2	0.4	1.0	0.2	1.0	-0.1	-1.0	-0.5
Hair Pigment	0.2	6.6	26.2	1.6	1.8	-0.9	-5.1	-0.2
Tanning	0.2	2.0	4.0	0.5	-1.8	1.4	2.0	0.5
Hand grip strength (left)	0.2	0.6	1.7	1.0	-1.3	-0.3	0.0	-0.4
Supplements: Zinc	0.2	0.2	0.7	-0.8	-0.4	0.3	-0.3	0.1
Hand grip strength (right)	0.2	0.5	1.4	0.4	-0.8	-1.2	-0.3	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.8	0.9	0.4	-0.9	-0.3	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	-0.5	-0.3	0.1	0.5	0.9
Heart attack	0.2	0.3	0.4	0.6	0.4	-0.1	-0.6	0.6
Asthma	0.2	0.5	1.3	0.7	-0.3	1.1	0.1	-0.7
Medication: Paracetamol	0.2	0.3	0.7	0.8	-0.3	0.3	0.9	-0.4
Headache pain in last month	0.2	0.3	0.7	-0.1	-0.1	-0.7	-0.6	-0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.6	0.2	-0.5	-0.2	0.8
Medication: Aspirin	0.2	0.2	0.6	-0.8	-0.2	-0.7	-0.1	-0.1
Knee pain experienced in last month	0.2	0.3	0.8	0.0	-0.1	-0.6	-0.9	-0.5
Medication for cholesterol	0.2	0.3	0.9	-0.6	-0.3	-0.4	1.0	0.4
Osteoporosis (self-reported)	0.2	0.3	0.9	-0.9	0.1	0.7	-0.3	-0.1
Medication: Aspirin	0.2	0.3	1.0	-1.0	0.3	-0.6	-0.1	-0.2
Miserableness	0.2	0.3	0.8	-0.9	0.5	-0.6	0.1	0.1
Mother’s age at death	0.2	0.3	0.6	0.3	-0.2	0.8	-0.5	0.6
Medication: Blood pressure	0.2	0.4	0.9	0.9	0.5	1.0	0.1	0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.9	-0.4	-0.2	0.6	0.9	-0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.0	0.2	0.3	-0.3	-0.3	1.0
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.5	-0.3	-0.5	-0.6	0.1
Depression (Nagel 2018)	0.1	0.1	0.4	0.1	0.6	-0.5	0.3	0.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.5	-0.7	0.3	-0.1	0.9
Crohns Disease (2012)	0.1	0.1	0.2	-0.1	-0.2	0.1	-0.4	0.5
Blood Eosinophil Count	0.1	0.7	2.4	-1.6	-0.4	-0.7	-0.6	0.4
Blood Platelet Count	0.1	0.7	1.1	1.1	-0.7	-1.0	0.5	0.8
Blood Red Count	0.1	1.4	3.8	-2.0	1.4	-0.1	-0.9	0.7
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.0	0.2	0.3	0.2	0.5
Relative age of first facial hair	0.1	0.3	0.6	-0.7	0.5	-0.2	-0.2	0.7
Pack years adult smoking proportion	0.1	0.2	0.4	0.6	0.6	-0.1	-0.3	-0.0
Sitting height	0.1	0.7	2.0	0.4	-0.6	-1.4	-0.9	-0.4
Illnesses of siblings	0.1	0.2	0.7	-0.1	0.8	0.4	-0.2	0.2
Falls in the last year	0.1	0.2	0.7	-0.1	0.4	0.1	0.9	-0.4
Emphysema/chronic bronchitis	0.1	0.2	0.5	0.0	-0.7	-0.4	0.3	0.3
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.5	0.6	0.4	0.2	0.0
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.1	-0.7	0.3	0.6	-0.1
Medication: Paracetamol	0.1	0.2	0.4	0.3	-0.1	0.0	0.7	0.5
Pack years of smoking	0.1	0.1	0.3	0.6	0.4	0.0	-0.2	0.2

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