Hub : Genes

FADD

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0680	0.0230	9.2e-04	0.061	0.022	0.054	0.039	0.057	6.2e-08	9.0e-04	3.7e-07	1.3e-05	1.6e-07
2	GTEx	Cells Transformed fibroblasts	0.0720	0.0270	3.8e-03	0.064	NA	0.061	NA	0.063	1.5e-05	NA	2.2e-05	NA	1.7e-05
3	GTEx	Esophagus Mucosa	0.1380	0.0510	3.2e-03	0.004	NA	0.009	NA	0.012	1.7e-01	NA	7.3e-02	NA	4.7e-02
4	NTR	Blood	0.0937	0.0170	0.0e+00	0.106	0.087	0.102	0.101	0.102	3.3e-32	1.4e-26	3.9e-31	8.1e-31	4.5e-31
5	ROSMAP	Brain Pre-frontal Cortex	0.1846	0.0352	0.0e+00	0.166	0.172	0.177	0.172	0.178	7.6e-21	1.7e-21	3.4e-22	1.4e-21	2.3e-22
6	YFS	Blood	0.0635	0.0143	2.7e-12	0.029	0.049	0.051	0.055	0.044	5.2e-10	1.4e-15	3.5e-16	1.7e-17	2.6e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.6	1.1	1.0	-0.8	-0.1	-0.8	1.1	-0.1
Bipolar Disorder or Schizophrenia	0.4	0.9	2.5	-0.5	-0.4	-1.4	-0.0	-0.5	-1.6
Depressed Affect (Nagel 2018)	0.5	1.1	2.4	1.3	-0.4	0.6	-1.5	1.5	0.1
Depression (Nagel 2018)	1.7	2.6	4.7	1.8	-1.7	-0.3	-2.2	2.2	-0.3
Intelligence (Savage-Jansen 2018)	3.3	10.1	15.2	3.5	-3.9	-0.8	-3.9	3.6	-2.1
Neuroticism (Nagel 2018)	0.1	0.3	0.9	0.1	1.0	0.7	0.1	0.1	0.7
Schizophrenia (2018)	0.9	1.8	3.8	-1.4	0.1	-1.7	0.7	-1.4	-1.9
Schizophrenia vs Biploar Disorder	0.2	0.3	1.1	-0.7	-0.1	-1.0	0.1	-0.6	-0.0
Worry (Nagel 2018)	0.3	0.7	1.2	-0.9	1.1	0.0	0.7	-1.0	-0.7
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.6	0.7	0.6	0.8	-0.3	0.4
Alzheimer’s Disease (in father)	1.3	1.4	2.7	0.9	-1.2	-1.6	-0.9	0.8	-1.5
Alzheimer’s Disease (including proxy)	0.6	0.8	1.6	0.9	-1.3	-0.2	-0.7	1.1	-0.8
Crohns Disease (2017)	0.1	0.3	0.7	-0.6	0.2	0.9	0.6	-0.3	-0.2
Irritable Bowel Disease (IBD)	0.3	0.6	1.5	-0.2	1.1	0.2	1.0	-0.1	1.2
Ulcerative Colitis (UC)	0.4	0.8	2.0	0.2	1.1	-0.8	0.8	0.2	1.4
Major Depression (MDD)	0.8	0.9	5.3	0.3	-0.2	-2.3	-0.0	0.5	-0.1
Reaction Time	0.2	0.4	1.8	-0.4	-0.2	0.6	-0.2	-0.1	-1.4
Verbal and Numeric Reasoning (VNR)	3.7	8.8	14.0	3.3	-3.6	-0.6	-3.7	3.2	-2.0
Breast Cancer	0.6	1.4	5.2	0.2	-0.9	1.6	-0.4	0.3	-2.3
Ovarian Cancer	0.1	0.2	0.4	-0.6	-0.3	-0.4	0.1	-0.7	-0.3
Prostate Cancer	0.9	1.3	2.3	1.0	-1.5	-0.9	-1.0	0.9	-1.3
Age at First Birth	0.4	0.6	1.3	-0.7	0.7	-0.3	0.4	-1.1	-0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.4	0.7	-1.2	-0.7	-1.0	0.8	-0.7
Coronary Artery Disease (CAD)	0.1	0.2	0.5	-0.6	0.0	0.7	0.3	-0.2	0.1
Crohns Disease (2012)	0.1	0.1	0.4	-0.5	0.1	0.5	0.6	-0.1	0.1
Mean Putamen Volume	1.0	1.1	2.9	-0.8	1.1	-1.7	1.2	-0.7	0.3
Fasting Glucose	0.2	0.3	0.7	0.5	-0.5	0.2	-0.5	0.8	-0.2
HbA1C	0.1	0.1	0.6	0.1	0.3	0.7	0.2	-0.2	-0.4
HDL Cholesterol	0.6	1.0	2.1	1.5	-0.4	-0.6	-1.2	1.5	-0.0
LDL Cholesterol	1.3	2.0	3.3	-1.3	1.6	1.8	1.4	-1.3	0.9
Lupus	0.3	0.5	0.8	0.7	-0.6	-0.7	-0.9	0.7	-0.6
Neuroticism (2016)	1.4	2.0	3.9	-1.1	2.0	-1.1	1.4	-1.2	1.5
Primary Biliary Cirrhosis	0.8	1.2	2.8	1.1	-1.4	-0.1	-1.7	0.9	-0.5
Rheumatoid Arthritis	0.6	0.8	1.8	0.7	-1.1	-1.4	-0.9	0.2	-0.4
Schizophrenia (2014)	0.8	1.7	3.0	-1.5	0.0	-1.7	0.8	-1.3	-1.6
Triglycerides	0.4	0.6	1.0	-1.0	0.7	0.9	0.8	-1.0	0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	-0.7	0.9	0.8	1.0	-0.8	0.3
Ulcerative Colitis	0.2	0.3	0.9	0.6	0.1	-0.4	-0.2	0.5	1.0
Blood Eosinophil Count	0.1	1.0	3.7	-0.5	-0.2	1.9	-0.4	0.3	-1.3
Blood Platelet Count	0.2	2.5	4.9	-1.5	2.2	1.1	1.7	-1.6	1.1
Blood Red Count	0.1	1.0	1.7	1.2	-0.8	0.2	-1.2	1.3	-0.9
Blood White Count	0.1	1.1	2.7	-0.4	1.3	1.6	0.2	-0.1	1.4
Heel T-Score	0.2	1.7	4.5	-1.1	0.2	2.1	1.4	-1.1	-1.0
BMI	0.5	2.7	5.8	2.4	-0.4	-0.5	-1.8	2.3	1.2
Height	1.6	30.9	63.4	4.4	-6.0	-8.0	-5.5	4.3	-4.2
Waist Hip Ratio (WHR)	1.7	7.8	13.9	-2.5	3.7	1.2	3.0	-2.5	3.2
Systolic Blood Pressure	0.3	1.3	4.7	-0.2	-1.1	1.0	-0.7	0.3	-2.2
Smoking Status	0.7	1.7	3.3	1.3	-1.8	-0.4	-1.3	1.2	-1.4
Allergy or Eczema	1.1	2.8	10.0	1.0	-1.4	-3.2	-1.7	0.9	-0.6
Cardiovascular Disease	1.1	3.6	6.7	1.0	-2.6	1.5	-2.0	1.1	-2.5
Hypothyroidism (self reported)	0.2	0.5	2.0	-0.1	0.4	-0.2	0.8	-0.1	1.4
Respiratory disease	1.5	3.2	7.4	1.2	-2.3	-0.4	-2.0	1.1	-2.7
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.3	1.2	0.2	1.1	-0.7	1.3	1.5
Lung FEV1/FVC ratio	1.9	9.5	15.9	4.0	-3.9	-0.6	-3.4	3.5	-1.4
Lung FVC	0.4	2.1	4.1	-2.0	0.8	1.2	1.2	-1.8	-1.3
Neuroticism	0.3	0.8	2.1	-0.8	1.1	1.5	0.5	-0.6	0.4
Chronotype (morning person)	0.8	1.9	3.3	-1.6	0.9	1.8	1.5	-1.4	0.0
Hair Pigment	0.3	9.2	14.1	-3.5	3.8	0.0	3.7	-3.7	1.1
Tanning	0.1	0.6	2.5	0.7	-0.4	-1.6	-0.6	0.5	0.2
Hand grip strength (left)	1.1	2.9	12.4	-1.4	-0.8	0.9	-0.1	-1.4	-3.5
Number of treatments/medications taken	0.0	0.1	0.2	0.1	-0.2	-0.5	-0.4	0.2	0.2
Average weekly spirits intake	0.1	0.1	0.3	-0.4	-0.4	-0.1	-0.3	-0.2	-0.5
Sensitivity / hurt feelings	2.0	3.4	5.4	-2.0	1.7	2.3	2.0	-2.1	0.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.8	1.3	-0.5	0.1	-1.2	1.3	0.7
Hearing difficulty/problems: Yes	0.5	0.7	2.3	0.8	0.3	-0.4	-0.4	0.9	1.5
Relative age of first facial hair	0.8	1.5	6.3	-0.7	0.6	-2.5	1.1	-0.8	0.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	5.1	0.2	0.0	-2.3	-0.1	0.2	0.6
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.4	-1.4	1.7	0.3	1.8	-1.3	1.0
Ever had hysterectomy (womb removed)	0.4	0.4	1.0	0.7	-0.3	0.4	-0.8	1.0	-0.2
Systolic blood pressure, automated reading	0.6	1.7	5.8	0.0	-1.1	1.2	-1.0	0.8	-2.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.0	-0.2	0.4	-1.0	-0.2	-0.0	-0.3
Angina	0.3	0.4	0.8	0.7	-0.7	0.2	-0.8	0.4	-0.9
Medication for hormone replacement therapy	0.2	0.2	0.8	-0.5	0.9	0.2	0.4	-0.4	0.2
Vitamin and mineral supplements	0.4	0.5	1.5	-0.7	0.5	-0.3	0.6	-0.6	1.2
Supplements: Zinc	1.2	1.3	3.7	1.1	-0.6	1.9	-0.9	0.8	-1.1
Medication: Co-codamol	0.5	0.6	1.3	-0.7	0.1	-1.1	0.2	-1.0	-0.7
Medication: Metformin	0.3	0.4	1.0	0.8	0.3	0.1	-0.6	1.0	0.3
Diabetes (father)	0.2	0.2	0.9	0.2	0.2	0.9	-0.1	0.1	0.6
Diabetes (mother)	0.8	1.0	1.4	1.1	-0.9	-0.9	-1.2	1.1	0.7
Severe depression (siblings)	0.2	0.2	0.4	0.3	-0.7	-0.3	-0.4	0.3	-0.4
Pack years adult smoking proportion	0.6	1.0	3.2	0.7	-1.0	-1.8	-0.6	0.6	0.5
Impedance of leg (right)	1.0	4.7	7.2	-1.5	2.3	2.6	2.1	-1.4	2.7
Leg fat-free mass (left)	2.1	11.3	22.4	2.9	-3.4	-4.7	-3.4	2.8	-2.4
Trunk fat percentage	1.0	3.9	10.7	2.3	0.6	-1.2	-1.1	2.2	3.3
Hand grip strength (right)	0.6	1.7	7.4	-0.7	-0.9	1.1	-0.6	-0.7	-2.7
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.0	0.6	0.8	0.5	-0.2	0.9
Current tobacco smoking	0.6	1.1	1.5	1.1	-1.2	-1.0	-1.0	1.2	-0.3
Average weekly fortified wine intake	0.8	1.0	1.7	-1.3	1.0	-0.9	1.1	-1.1	0.3
Maternal smoking around birth	1.0	1.4	4.5	1.0	-0.9	-2.1	-1.0	0.9	0.6
Fed-up feelings	1.1	2.1	4.2	1.9	-0.8	0.1	-1.9	2.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	5.4	1.5	-2.2	-1.0	-2.3	2.0	-1.2
Relative age voice broke	0.1	0.1	0.4	0.1	0.1	-0.2	0.2	0.1	0.6
Taking other prescription medications	1.0	1.6	3.8	1.3	-0.6	-2.0	-1.1	1.3	0.8
Age when periods started (menarche)	0.3	0.6	1.5	1.2	-0.3	-0.0	-0.7	0.8	0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	0.8	-0.2	0.3	-0.5	0.8	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.3	-1.4	1.8	-0.4	1.7	-1.4	1.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	3.5	-0.3	-0.1	-1.9	0.0	-0.3	-0.7
Qualifications: CSEs or equivalent	0.2	0.3	1.0	-0.5	0.3	1.0	0.3	-0.6	0.1
Serious illness, injury or assault to yourself	0.2	0.3	0.7	-0.7	0.4	-0.5	0.3	-0.4	0.8
High blood pressure	1.2	3.3	9.7	0.2	-2.5	1.2	-1.5	0.4	-3.1
Hayfever, allergic rhinitis or eczema	0.8	1.6	6.5	0.7	-1.0	-2.5	-1.0	0.5	-0.7
Multivitamins +/- minerals	0.4	0.5	1.3	-0.6	0.4	0.5	0.5	-0.8	-1.1
Stomach or abdominal pain in last month	1.3	1.6	4.3	0.2	-1.2	-1.9	-0.5	0.0	-2.1
Supplements: Glucosamine	0.6	0.7	2.8	0.8	0.3	-1.7	-0.5	0.8	0.3
Diverticular disease/diverticulitis (self-reported)	5.3	6.2	8.6	2.8	-2.9	-1.5	-2.5	2.3	-2.7
Medication: Atenolol	0.2	0.2	0.4	-0.7	-0.0	0.4	0.3	-0.7	-0.5
Medication: Levothyroxine sodium	0.3	0.6	1.1	-0.6	0.6	0.9	1.1	-0.6	0.6
Sitting height	0.8	5.8	11.0	1.5	-3.3	-2.5	-2.1	1.5	-2.9
Chronic bronchitis/emphysema (father)	3.1	3.7	5.5	2.0	-1.9	-1.9	-2.4	2.1	-1.0
High blood pressure (mother)	0.5	0.8	2.2	-0.6	-0.5	-1.5	0.5	-0.7	-1.0
Body mass index (BMI)	0.3	1.4	3.0	1.7	-0.1	-0.7	-1.1	1.6	1.1
Impedance of leg (left)	1.1	5.3	9.7	-1.6	2.6	1.9	2.5	-1.6	3.1
Leg predicted mass (left)	2.2	11.5	23.0	2.9	-3.5	-4.8	-3.4	2.8	-2.5
Trunk fat mass	0.9	4.0	6.3	2.5	-0.2	-2.0	-1.6	2.4	2.3
Waist circumference	0.4	1.5	3.4	1.5	0.3	-0.9	-0.6	1.4	1.8
Number of incorrect matches in round	0.5	0.8	1.7	-1.0	0.5	1.3	0.8	-0.9	-0.6
Past tobacco smoking	0.5	0.9	1.8	-0.9	1.4	0.6	0.9	-0.7	1.2
Alcohol usually taken with meals	0.5	0.8	2.2	-0.0	-1.0	1.5	-0.1	-0.1	-1.2
Nervous feelings	0.3	0.5	0.9	-0.9	1.0	0.1	0.7	-0.9	-0.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.4	1.1	-1.4	-0.9	-1.5	1.0	-1.4
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.5	-0.1	-0.6	-0.7	0.3	-0.0
Hair/balding pattern: Pattern 2	0.5	0.6	2.9	-0.1	-0.4	-1.7	-0.3	-0.1	-0.6
Had menopause	0.5	0.6	2.1	0.7	0.1	-1.4	-0.2	1.0	0.6
Had other major operations	2.3	2.8	9.9	0.9	-1.6	-3.1	-1.5	1.0	-0.7
Forced vital capacity (FVC)	0.4	1.7	5.7	-0.0	-1.1	-2.4	-0.9	0.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	4.8	-1.6	2.0	-0.5	2.2	-1.7	1.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	3.4	-0.2	0.0	-1.8	0.3	-0.1	0.2
Qualifications: None of the above	0.5	1.2	1.6	1.1	-1.2	-0.0	-1.2	1.3	-1.1
Financial difficulties in last 2 years	0.6	0.8	1.5	-1.2	0.9	-0.2	0.9	-1.2	-0.2
Mouth/teeth dental problems	0.7	1.0	2.9	1.0	-1.7	-0.7	-1.0	0.5	-0.8
Heart attack	0.1	0.1	0.3	-0.3	0.0	0.4	0.0	-0.5	-0.1
Allergy	0.9	2.1	3.5	-1.3	1.8	1.1	1.9	-1.1	1.5
Pain all over the body in last month	0.6	0.6	3.6	0.0	0.2	-1.9	-0.3	-0.1	0.0
Diabetes (self-reported)	0.3	0.4	1.1	-0.1	1.1	0.4	0.3	-0.0	1.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.2	0.8	-1.2	-0.6	-1.3	0.7	-1.5
Medication: Ramipril	0.5	0.6	1.0	1.0	-0.4	0.9	-1.0	0.8	-0.2
Medication: Simvastatin	0.2	0.2	1.3	-0.1	-0.1	1.1	-0.1	-0.2	0.2
Fluid intelligence score	1.1	2.2	3.8	1.8	-1.7	-0.3	-1.8	1.9	-0.2
Illnesses of siblings	0.2	0.2	0.6	0.8	0.1	0.6	-0.5	0.4	-0.3
Neuroticism score	0.2	0.5	1.2	-0.7	1.1	0.4	0.6	-0.7	0.3
Weight	1.1	5.5	9.9	2.6	-1.9	-3.1	-2.5	2.5	-0.3
Impedance of arm (right)	0.3	1.3	4.2	-0.6	1.3	0.4	1.2	-0.5	2.0
Arm fat percentage (right)	0.5	2.1	5.5	1.7	0.5	-0.7	-0.8	1.6	2.3
Trunk fat-free mass	1.9	11.0	16.6	2.4	-3.9	-4.1	-3.3	2.4	-3.5
Hip circumference	1.1	4.8	8.0	2.8	-1.3	-2.6	-2.3	2.6	0.2
Time employed in main current job	1.5	1.7	2.8	-1.5	1.7	0.8	1.6	-1.2	0.9
Alcohol intake versus 10 years previously	0.4	0.5	2.0	-0.5	0.1	-1.4	0.6	-0.7	-0.2
Father’s age at death	2.3	3.2	5.0	-1.9	2.2	-0.2	2.2	-1.8	1.6
Worrier / anxious feelings	0.5	1.0	3.0	-0.9	1.7	-0.3	1.0	-1.1	-0.1
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.0	1.7	-0.1	-2.0	-1.6	1.7	1.4
Falls in the last year	0.6	0.8	2.9	-0.5	0.7	-1.7	0.6	-0.6	0.8
Hair/balding pattern: Pattern 3	0.8	1.2	2.4	0.7	-1.6	0.3	-0.9	0.9	-1.5
Number of live births	0.1	0.1	0.6	0.0	0.3	-0.8	0.3	0.2	0.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	8.8	0.4	-1.4	-3.0	-1.0	0.4	-1.8
Pulse rate	0.8	1.3	2.8	1.7	-0.6	0.5	-1.2	1.5	0.8
Happiness	0.9	1.1	1.5	1.2	-1.0	-0.6	-1.2	1.1	-1.1
Noisy workplace	0.4	0.5	2.5	0.4	-0.4	-1.6	-0.5	0.3	0.2
Qualifications: A levels/AS levels or equivalent	1.1	2.3	4.9	2.2	-1.6	0.0	-1.6	1.9	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.1	1.0	-1.3	-0.2	-1.0	1.1	-1.4
Mouth/teeth dental problems: Dentures	0.5	0.8	1.8	0.8	-0.7	0.4	-0.9	0.9	-1.4
Asthma	1.0	1.9	5.6	0.6	-1.7	0.2	-1.4	0.5	-2.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.7	0.1	0.9	0.4	0.2	-0.1	1.3
Medication: Cholesterol lowering	0.3	0.4	1.1	-0.1	0.6	1.1	0.2	-0.3	0.9
Depression (self-reported)	0.1	0.1	0.3	0.4	0.0	-0.3	-0.0	0.5	0.4
Medication: Lansoprazole	0.5	0.6	2.4	0.5	0.6	-0.5	0.3	0.2	1.5
Prospective memory result	0.1	0.2	0.5	-0.4	0.2	-0.7	0.1	-0.4	-0.4
Lung cancer (father)	0.2	0.2	0.3	0.5	0.4	0.4	-0.5	0.5	0.5
Illnesses of mother	0.6	0.7	3.3	-0.0	0.8	1.8	0.2	-0.1	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	6.2	0.4	-1.4	-2.5	-0.9	0.3	-1.9
Pulse wave Arterial Stiffness index	1.4	1.6	3.0	1.6	-0.6	-0.8	-1.3	1.7	1.2
Impedance of arm (left)	0.5	2.3	10.2	-0.3	1.6	-0.0	1.1	-0.2	3.2
Arm fat mass (right)	0.9	3.6	5.9	2.4	-0.5	-2.1	-1.7	2.3	1.6
Trunk predicted mass	1.9	10.7	16.9	2.3	-3.8	-4.1	-3.2	2.3	-3.5
Standing height	1.5	15.3	32.3	2.9	-4.4	-5.7	-3.8	2.9	-3.0
Length of working week for main job	2.0	2.2	3.9	1.9	-1.4	-0.6	-2.0	1.7	-0.6
Exposure to tobacco smoke at home	0.2	0.3	0.6	-0.5	0.8	0.0	0.6	-0.6	0.2
Breastfed as a baby	0.7	0.8	1.7	1.3	-0.8	0.4	-1.1	1.2	-0.1
Tense / ‘highly strung’	0.1	0.2	0.4	0.5	-0.6	-0.2	-0.5	0.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	5.2	0.2	1.1	-0.6	0.5	-0.0	2.3
Hair/balding pattern: Pattern 4	0.9	2.2	4.0	-1.2	2.0	1.1	1.5	-1.2	1.6
Birth weight of first child	1.2	2.3	4.4	1.5	-2.1	-0.7	-1.8	1.2	-1.4
Peak expiratory flow (PEF)	0.7	1.6	7.9	0.4	-0.7	-2.8	-0.6	0.3	-0.6
Pulse wave reflection index	1.4	1.7	2.8	1.3	-1.4	-1.7	-1.3	1.4	-0.3
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.6	0.3	-0.7	-2.1	-0.8	0.8	1.1
Loud music exposure frequency	1.0	1.1	3.9	-0.6	0.6	-2.0	0.9	-0.5	0.8
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	0.2	-0.3	0.9	-0.2	0.1	0.2
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	4.9	-1.6	1.8	2.2	1.5	-1.1	1.5
Blood clot in the leg (DVT)	0.1	0.1	0.7	0.0	0.8	0.1	0.1	-0.2	0.4
Medication: Paracetamol	0.9	1.6	2.8	-1.7	1.3	-0.1	1.5	-1.5	0.6
Headache pain in last month	1.5	2.5	4.1	-2.0	2.0	-0.2	1.8	-1.8	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	-0.9	0.8	-1.2	1.1	-0.7	-0.0
Glaucoma (self-reported)	0.9	1.0	3.4	0.0	0.3	-1.9	0.1	-0.0	1.6
Gout (self-reported)	0.2	0.2	0.6	0.3	-0.1	0.8	-0.2	0.3	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.8	-0.5	0.6	0.5	1.2	-0.4	1.3
Medication: Amlodipine	0.3	0.4	1.5	-0.3	-0.5	0.8	-0.3	-0.2	-1.2
Medication: Ventolin 100micrograms inhaler	2.9	3.8	7.5	1.6	-2.4	-0.6	-2.0	1.5	-2.7
Birth weight	0.7	1.5	5.2	-0.6	-1.5	-0.8	-0.6	-0.3	-2.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	0.8	-1.0	-0.3	-1.1	0.9	0.0
High blood pressure (siblings)	0.7	1.1	1.8	-1.2	-0.3	-1.1	0.7	-1.1	-1.3
Forced vital capacity (FVC), Best measure	0.5	1.8	5.7	-0.2	-1.1	-2.4	-0.6	-0.1	-1.9
Body fat percentage	0.8	3.2	11.5	1.7	1.1	-0.8	-0.5	1.6	3.4
Leg fat percentage (right)	0.6	2.2	9.2	0.9	1.4	0.8	0.1	0.9	3.0
Arm fat-free mass (right)	1.4	7.1	13.8	2.5	-2.6	-3.7	-2.8	2.4	-1.4
Exposure to tobacco smoke outside home	0.5	0.6	1.1	-0.9	0.7	-1.0	0.9	-0.6	-0.1
Comparative body size at age 10	0.7	1.9	4.7	-1.5	0.9	2.2	1.1	-1.5	-0.0
Number of full brothers	1.0	1.2	2.2	1.5	-0.9	-0.9	-1.1	1.3	-0.6
Worry too long after embarrassment	0.4	0.7	1.5	-0.3	1.1	0.7	0.8	-0.3	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-0.5	1.0	0.0	1.0	-0.8	0.2
Wheeze or whistling in the chest in last year	1.2	2.1	3.9	1.2	-1.4	-1.5	-1.4	0.9	-2.0
Number of children fathered	0.2	0.2	0.4	-0.4	0.5	-0.2	0.6	-0.4	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	-1.1	0.5	-0.3	0.8	-1.4	-0.4
Age at first live birth	0.6	1.0	2.8	0.5	-1.7	-0.2	-0.9	0.7	-1.3
Pulse wave peak to peak time	1.7	2.0	3.9	-1.9	0.6	0.4	1.5	-2.0	-1.4
Health satisfaction	1.8	2.3	4.1	1.6	-1.5	-1.7	-2.0	1.6	-0.3
Shortness of breath walking on level ground	0.6	0.7	2.2	0.6	-1.0	0.0	-0.8	0.4	-1.5
Qualifications: College or University degree	0.4	1.2	4.6	0.8	-0.4	-2.1	-0.2	0.7	1.1
Eye problems/disorders: None of the above	0.7	0.8	1.4	1.1	-1.2	-0.1	-0.7	0.9	-0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.3	-0.4	0.1	1.1	0.3	-0.3	0.1
Emphysema/chronic bronchitis	2.1	2.4	3.3	1.6	-1.5	1.8	-1.5	1.5	-1.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.6	-0.1	-0.3	-0.3	0.6	0.3
Neck or shoulder pain in last month	0.8	1.2	2.1	-1.2	1.2	1.4	0.9	-0.7	0.7
Medication: Blood pressure	0.7	1.2	2.0	0.9	-1.4	0.9	-1.4	0.8	-1.0
Angina (self-reported)	0.2	0.2	0.5	0.4	-0.4	0.3	-0.5	0.2	-0.7
Migraine (self-reported)	0.8	1.0	2.1	-1.5	0.8	-1.1	1.1	-0.9	-0.0
Medication: Ibuprofen	0.7	0.8	1.9	-1.0	1.4	0.2	0.9	-1.1	0.4
Medication: Allopurinol	0.3	0.4	0.6	0.8	-0.7	-0.3	-0.8	0.7	-0.2
Medication: Omeprazole	0.2	0.2	1.1	-0.3	-0.4	0.3	-0.0	-0.2	-1.0
Medication: Seretide 50 evohaler	0.3	0.3	1.1	-0.6	-0.2	0.4	-0.0	-0.5	-1.1
Mean time to correctly identify matches	0.2	0.3	1.1	0.0	-0.2	0.6	-0.6	0.3	-1.0
Heart disease (mother)	0.6	0.7	1.0	-0.9	0.8	-0.9	1.0	-0.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.4	1.5	-1.2	0.8	-1.0	1.5	-0.6
Whole body fat mass	0.9	3.7	6.2	2.5	-0.4	-2.1	-1.7	2.3	1.9
Leg fat mass (right)	0.5	2.1	4.0	1.8	0.2	-1.3	-1.0	1.6	2.0
Arm predicted mass (right)	1.5	7.9	14.3	2.6	-2.9	-3.8	-2.9	2.5	-1.9
Pulse rate, automated reading	0.2	0.6	1.8	0.6	-0.1	1.4	-0.4	0.9	0.5
Alcohol intake frequency.	0.6	1.4	3.2	-1.8	0.2	-1.1	1.1	-1.6	-0.2
Comparative height size at age 10	1.3	7.3	12.8	2.0	-3.1	-3.6	-2.4	1.9	-2.8
Number of full sisters	1.8	2.1	5.3	-1.2	1.7	-2.3	1.2	-1.3	0.3
Suffer from ‘nerves’	1.1	1.7	3.1	-1.6	1.7	-0.2	1.2	-1.8	0.1
Overall health rating	0.8	1.8	5.3	0.1	1.0	-2.3	0.3	0.0	2.1
Chest pain or discomfort	1.4	2.0	3.2	-1.7	0.7	-1.8	1.4	-1.8	-0.4
Had major operations	0.3	0.4	0.6	-0.6	0.4	-0.7	0.8	-0.6	0.6
Age at last live birth	1.2	1.8	5.2	0.2	-1.9	-1.2	-0.7	0.3	-2.3
Family relationship satisfaction	0.4	0.4	0.8	0.8	-0.7	0.4	-0.6	0.9	-0.4
Leg pain on walking	0.3	0.3	0.8	-0.6	0.7	-0.9	0.3	-0.4	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	3.1	-0.5	-0.1	-1.8	0.0	-0.3	-0.7
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	0.1	-0.5	-0.5	-0.3	0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	-0.6	1.0	0.7	0.7	-0.7	0.6
Medication: Aspirin	0.8	1.1	2.0	1.4	-0.7	-0.4	-1.4	1.3	0.3
Supplements: Vitamin C	1.1	1.3	2.9	1.3	-1.0	1.7	-0.9	1.2	-0.2
Knee pain experienced in last month	0.5	0.7	2.6	-0.6	1.0	1.6	0.4	-0.3	0.4
Hypertension (Self-reported)	1.1	2.9	9.6	-0.1	-2.3	1.0	-1.2	0.0	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	5.1	1.0	-0.9	-2.3	-1.1	0.8	-0.5
Illnesses of father: Heart disease	0.2	0.2	1.3	-0.3	-0.2	1.1	-0.1	0.2	-0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.4	-0.5	0.6	0.6	0.2	-0.4	-0.0
Smoking status: Previous	0.3	0.5	0.9	0.7	-0.9	-0.3	-0.6	0.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	7.2	2.2	-2.6	-1.1	-2.7	2.1	-1.7
Whole body fat-free mass	1.9	11.1	20.2	2.5	-3.7	-4.5	-3.3	2.5	-3.1
Leg fat-free mass (right)	2.2	12.0	26.3	2.8	-3.5	-5.1	-3.4	2.7	-2.5
Arm fat percentage (left)	0.9	3.4	10.0	2.1	0.6	-0.9	-1.0	2.0	3.2
Average weekly red wine intake	1.2	1.8	7.5	-0.8	0.5	2.7	1.1	-1.0	0.3
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.6	0.5	-0.8	-1.6	-0.8	0.4	-0.7
Mood swings	0.3	0.5	1.0	-1.0	0.5	0.8	0.5	-0.8	-0.1
Loneliness, isolation	0.2	0.2	1.0	-0.1	1.0	-0.0	0.1	-0.1	0.5
Long-standing illness, disability or infirmity	0.4	0.5	1.7	0.7	-0.4	-1.3	-0.8	0.5	0.1
Ever had bowel cancer screening	1.2	1.4	3.1	1.4	-0.1	-1.8	-0.8	1.2	1.2
Diabetes diagnosed by doctor	0.3	0.4	1.5	0.3	0.8	0.3	-0.1	0.5	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	3.6	-0.1	0.2	-0.3	1.0	0.0	1.9
Friendships satisfaction	1.5	1.8	3.1	1.5	-1.5	0.4	-1.7	1.8	-0.5
Qualifications: nursing, teaching	1.3	2.1	3.7	-0.9	1.9	-1.0	1.5	-1.3	1.8
Commuting to job workplace: Walk	0.2	0.3	0.5	0.7	-0.5	-0.4	-0.7	0.4	0.3
Eye problems/disorders: Cataract	0.4	0.4	0.8	-0.7	0.9	0.6	0.3	-0.7	0.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.2	-1.3	1.5	0.3	1.5	-1.1	1.1
Medication for cholesterol	0.1	0.1	0.4	0.3	0.3	-0.4	-0.1	0.2	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.5	-0.6	-0.4	1.9	0.4	-0.7	-0.2
Back pain experienced in last month	0.2	0.2	0.5	0.1	-0.7	-0.4	-0.3	0.2	-0.7
Mineral and other dietary supplements	0.8	1.1	3.1	-1.3	0.4	1.8	0.9	-1.0	0.1
Breast cancer (self-reported)	1.2	1.5	4.3	-0.9	1.2	-2.1	1.0	-0.8	0.7
Asthma (self-reported)	0.9	1.7	4.8	0.7	-1.5	0.7	-1.4	0.6	-2.2
Osteoporosis (self-reported)	0.7	0.8	1.5	1.2	-0.6	-0.7	-0.5	1.2	1.0
Osteoarthritis (self-reported)	0.3	0.3	0.9	0.2	-0.0	-0.8	-0.4	0.5	0.9
Medication: Aspirin	0.6	0.8	1.5	1.2	-0.3	-0.6	-1.2	1.1	0.6
Medication: Gliclazide	0.4	0.4	2.2	-0.1	0.4	-1.5	-0.2	-0.2	-0.0
Illnesses of father: None of the above (group 1)	2.9	3.6	6.5	-2.4	1.7	0.8	2.3	-2.5	0.0
Smoking status: Current	0.5	0.8	1.3	0.8	-1.1	-1.0	-0.9	1.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.3	-0.9	1.1	-0.3	1.0	-1.1	0.9
Whole body water mass	2.0	11.7	20.5	2.7	-3.8	-4.5	-3.4	2.7	-3.0
Leg predicted mass (right)	2.2	11.7	25.4	2.8	-3.5	-5.0	-3.3	2.7	-2.5
Arm fat mass (left)	1.0	3.9	6.4	2.5	-0.5	-2.1	-1.8	2.4	1.8
Number of self-reported non-cancer illnesses	1.0	1.7	3.3	0.7	-1.8	-1.4	-1.5	0.7	-1.3
Average weekly champagne plus white wine intake	1.7	2.3	3.3	-1.4	1.3	1.8	1.8	-1.2	1.5
Miserableness	0.6	1.0	2.0	1.4	-0.8	0.0	-1.3	1.4	0.1
Guilty feelings	1.0	1.5	5.8	-0.1	1.5	0.2	0.9	0.2	2.4
Wears glasses or contact lenses	0.4	0.5	2.0	0.1	0.4	-1.4	0.0	0.2	0.8
Ever taken oral contraceptive pill	0.8	0.9	1.6	-1.2	0.5	1.1	1.1	-1.3	-0.3
Hearing aid user	0.6	0.7	1.7	0.8	-0.4	-1.0	-0.4	0.7	1.3
Mother’s age at death	0.3	0.4	0.9	-0.1	0.4	0.9	0.5	0.1	1.0
Financial situation satisfaction	0.5	0.6	1.5	0.7	-1.2	-0.4	-0.7	0.6	-0.8
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.6	0.7	-0.4	0.3	-0.3	0.8	0.3
Commuting to job workplace: Public transport	1.9	2.3	5.3	-1.1	2.3	0.8	1.6	-1.4	1.5
Eye problems/disorders: Glaucoma	0.6	0.7	1.1	-0.6	0.8	-1.0	0.8	-0.6	1.1
Medication: Blood pressure	0.5	1.0	3.4	-0.7	-1.2	0.3	-0.3	-0.6	-1.8
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.8	-1.1	1.7	-1.6	0.9	-1.3	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.6	3.1	0.3	0.5	-1.8	-0.0	0.1	0.5
High cholesterol (Self-reported)	1.3	2.3	3.7	1.8	-1.9	0.7	-1.7	1.8	-0.8
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.6	0.4	-0.1	0.6	-0.5	0.1
Medication: Paracetamol	1.5	2.4	4.2	-2.0	1.6	0.6	1.9	-1.8	0.2
Medication: Lisinopril	1.9	2.5	4.8	0.6	-2.2	1.8	-1.2	0.7	-2.2
Medication: Atorvastatin	0.5	0.6	1.2	1.1	-0.0	-0.6	-1.0	1.0	0.4
Illnesses of father: High blood pressure	1.5	1.9	3.8	1.4	-2.0	-0.4	-1.5	1.3	-1.3
Alcohol drinker status: Never	1.5	1.8	3.2	-1.8	1.1	0.5	1.5	-1.5	1.4
Ever smoked	0.8	1.5	3.1	1.0	-1.8	0.3	-1.0	0.9	-1.6
Basal metabolic rate	1.8	10.2	20.2	2.7	-3.4	-4.5	-3.2	2.6	-2.4
Leg fat percentage (left)	0.7	2.5	10.8	1.0	1.5	0.0	0.1	0.9	3.3
Arm fat-free mass (left)	1.5	7.4	13.8	2.1	-2.9	-3.7	-2.7	2.1	-2.4
Number of operations (self-reported)	0.2	0.3	1.4	0.3	-0.3	-1.2	-0.2	0.2	0.0
Average weekly beer plus cider intake	0.7	1.0	2.6	-1.2	0.9	0.4	1.6	-1.0	0.6
Irritability	0.2	0.3	0.6	0.8	-0.7	0.4	-0.7	0.5	0.0
Risk taking	0.9	1.4	2.7	-0.8	0.9	-1.6	1.2	-0.8	1.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.3	-0.6	0.5	-0.1	0.3	-0.3
Fractured/broken bones in last 5 years	3.1	4.0	6.9	-2.6	2.4	0.1	2.5	-2.2	0.7
Age started oral contraceptive pill	0.3	0.3	1.1	-0.2	0.4	1.1	0.7	-0.3	0.2
Diastolic blood pressure, automated reading	3.7	11.5	19.4	2.6	-4.4	1.8	-3.8	3.1	-3.9
Ever depressed for a whole week	0.2	0.3	0.7	-0.1	0.4	-0.9	0.3	-0.0	0.7
Unable to work because of sickness or disability	0.8	1.1	1.7	-1.1	0.9	-1.3	1.1	-1.0	0.6
Commuting to job workplace: Cycle	0.4	0.5	1.1	0.6	-1.1	-0.3	-0.3	0.8	-0.8
Myopia	0.4	0.5	1.2	1.1	-0.6	-0.1	-0.9	0.8	-0.4
Vascular/heart problems diagnosed by doctor	1.5	4.1	9.4	-0.8	2.8	-1.2	2.0	-0.9	3.1
Cholesterol lowering medication	0.6	0.9	1.6	1.3	-1.2	-0.3	-1.1	1.1	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.1	-0.2	-0.5	-0.2	0.1	-0.3	-1.1
Pain experienced in last month	0.5	0.8	1.7	1.3	-1.0	0.4	-0.8	1.1	-0.1
Supplements: Calcium	0.8	0.9	2.2	1.2	-0.7	-0.5	-0.9	1.5	-0.3
Basal cell carcinoma (self-reported)	0.8	1.0	1.7	1.2	-0.7	-0.8	-1.3	1.2	0.3
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.2	-0.0	-0.0	-0.0	-0.4	0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.8	-0.1	0.9	0.6	0.1	-0.2	0.2
Heart disease (siblings)	0.6	0.8	3.9	0.2	0.3	0.1	0.1	0.8	2.0
Alcohol drinker status: Previous	0.8	0.9	4.7	0.2	-0.6	-2.2	-0.3	0.1	-0.3
Pack years of smoking	0.8	1.1	2.3	1.1	-1.2	-1.5	-0.9	1.0	0.4
Impedance of whole body	0.8	3.9	12.1	-0.9	2.3	1.0	1.9	-0.9	3.5
Leg fat mass (left)	0.6	2.3	4.7	1.6	0.3	-1.8	-0.9	1.4	2.2
Arm predicted mass (left)	1.5	7.6	15.8	2.2	-2.8	-4.0	-2.7	2.2	-2.2