Hub : Genes

FADD

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0680 0.0230 9.2e-04 0.061 0.022 0.054 0.039 0.057 6.2e-08 9.0e-04 3.7e-07 1.3e-05 1.6e-07
2 GTEx Cells Transformed fibroblasts 0.0720 0.0270 3.8e-03 0.064 NA 0.061 NA 0.063 1.5e-05 NA 2.2e-05 NA 1.7e-05
3 GTEx Esophagus Mucosa 0.1380 0.0510 3.2e-03 0.004 NA 0.009 NA 0.012 1.7e-01 NA 7.3e-02 NA 4.7e-02
4 NTR Blood 0.0937 0.0170 0.0e+00 0.106 0.087 0.102 0.101 0.102 3.3e-32 1.4e-26 3.9e-31 8.1e-31 4.5e-31
5 ROSMAP Brain Pre-frontal Cortex 0.1846 0.0352 0.0e+00 0.166 0.172 0.177 0.172 0.178 7.6e-21 1.7e-21 3.4e-22 1.4e-21 2.3e-22
6 YFS Blood 0.0635 0.0143 2.7e-12 0.029 0.049 0.051 0.055 0.044 5.2e-10 1.4e-15 3.5e-16 1.7e-17 2.6e-14

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.6 1.1 1.0 -0.8 -0.1 -0.8 1.1 -0.1
Bipolar Disorder or Schizophrenia 0.4 0.9 2.5 -0.5 -0.4 -1.4 -0.0 -0.5 -1.6
Depressed Affect (Nagel 2018) 0.5 1.1 2.4 1.3 -0.4 0.6 -1.5 1.5 0.1
Depression (Nagel 2018) 1.7 2.6 4.7 1.8 -1.7 -0.3 -2.2 2.2 -0.3
Intelligence (Savage-Jansen 2018) 3.3 10.1 15.2 3.5 -3.9 -0.8 -3.9 3.6 -2.1
Neuroticism (Nagel 2018) 0.1 0.3 0.9 0.1 1.0 0.7 0.1 0.1 0.7
Schizophrenia (2018) 0.9 1.8 3.8 -1.4 0.1 -1.7 0.7 -1.4 -1.9
Schizophrenia vs Biploar Disorder 0.2 0.3 1.1 -0.7 -0.1 -1.0 0.1 -0.6 -0.0
Worry (Nagel 2018) 0.3 0.7 1.2 -0.9 1.1 0.0 0.7 -1.0 -0.7
Alzheimer’s Disease (in mother) 0.3 0.4 0.7 -0.6 0.7 0.6 0.8 -0.3 0.4
Alzheimer’s Disease (in father) 1.3 1.4 2.7 0.9 -1.2 -1.6 -0.9 0.8 -1.5
Alzheimer’s Disease (including proxy) 0.6 0.8 1.6 0.9 -1.3 -0.2 -0.7 1.1 -0.8
Crohns Disease (2017) 0.1 0.3 0.7 -0.6 0.2 0.9 0.6 -0.3 -0.2
Irritable Bowel Disease (IBD) 0.3 0.6 1.5 -0.2 1.1 0.2 1.0 -0.1 1.2
Ulcerative Colitis (UC) 0.4 0.8 2.0 0.2 1.1 -0.8 0.8 0.2 1.4
Major Depression (MDD) 0.8 0.9 5.3 0.3 -0.2 -2.3 -0.0 0.5 -0.1
Reaction Time 0.2 0.4 1.8 -0.4 -0.2 0.6 -0.2 -0.1 -1.4
Verbal and Numeric Reasoning (VNR) 3.7 8.8 14.0 3.3 -3.6 -0.6 -3.7 3.2 -2.0
Breast Cancer 0.6 1.4 5.2 0.2 -0.9 1.6 -0.4 0.3 -2.3
Ovarian Cancer 0.1 0.2 0.4 -0.6 -0.3 -0.4 0.1 -0.7 -0.3
Prostate Cancer 0.9 1.3 2.3 1.0 -1.5 -0.9 -1.0 0.9 -1.3
Age at First Birth 0.4 0.6 1.3 -0.7 0.7 -0.3 0.4 -1.1 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 1.4 0.7 -1.2 -0.7 -1.0 0.8 -0.7
Coronary Artery Disease (CAD) 0.1 0.2 0.5 -0.6 0.0 0.7 0.3 -0.2 0.1
Crohns Disease (2012) 0.1 0.1 0.4 -0.5 0.1 0.5 0.6 -0.1 0.1
Mean Putamen Volume 1.0 1.1 2.9 -0.8 1.1 -1.7 1.2 -0.7 0.3
Fasting Glucose 0.2 0.3 0.7 0.5 -0.5 0.2 -0.5 0.8 -0.2
HbA1C 0.1 0.1 0.6 0.1 0.3 0.7 0.2 -0.2 -0.4
HDL Cholesterol 0.6 1.0 2.1 1.5 -0.4 -0.6 -1.2 1.5 -0.0
LDL Cholesterol 1.3 2.0 3.3 -1.3 1.6 1.8 1.4 -1.3 0.9
Lupus 0.3 0.5 0.8 0.7 -0.6 -0.7 -0.9 0.7 -0.6
Neuroticism (2016) 1.4 2.0 3.9 -1.1 2.0 -1.1 1.4 -1.2 1.5
Primary Biliary Cirrhosis 0.8 1.2 2.8 1.1 -1.4 -0.1 -1.7 0.9 -0.5
Rheumatoid Arthritis 0.6 0.8 1.8 0.7 -1.1 -1.4 -0.9 0.2 -0.4
Schizophrenia (2014) 0.8 1.7 3.0 -1.5 0.0 -1.7 0.8 -1.3 -1.6
Triglycerides 0.4 0.6 1.0 -1.0 0.7 0.9 0.8 -1.0 0.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.1 -0.7 0.9 0.8 1.0 -0.8 0.3
Ulcerative Colitis 0.2 0.3 0.9 0.6 0.1 -0.4 -0.2 0.5 1.0
Blood Eosinophil Count 0.1 1.0 3.7 -0.5 -0.2 1.9 -0.4 0.3 -1.3
Blood Platelet Count 0.2 2.5 4.9 -1.5 2.2 1.1 1.7 -1.6 1.1
Blood Red Count 0.1 1.0 1.7 1.2 -0.8 0.2 -1.2 1.3 -0.9
Blood White Count 0.1 1.1 2.7 -0.4 1.3 1.6 0.2 -0.1 1.4
Heel T-Score 0.2 1.7 4.5 -1.1 0.2 2.1 1.4 -1.1 -1.0
BMI 0.5 2.7 5.8 2.4 -0.4 -0.5 -1.8 2.3 1.2
Height 1.6 30.9 63.4 4.4 -6.0 -8.0 -5.5 4.3 -4.2
Waist Hip Ratio (WHR) 1.7 7.8 13.9 -2.5 3.7 1.2 3.0 -2.5 3.2
Systolic Blood Pressure 0.3 1.3 4.7 -0.2 -1.1 1.0 -0.7 0.3 -2.2
Smoking Status 0.7 1.7 3.3 1.3 -1.8 -0.4 -1.3 1.2 -1.4
Allergy or Eczema 1.1 2.8 10.0 1.0 -1.4 -3.2 -1.7 0.9 -0.6
Cardiovascular Disease 1.1 3.6 6.7 1.0 -2.6 1.5 -2.0 1.1 -2.5
Hypothyroidism (self reported) 0.2 0.5 2.0 -0.1 0.4 -0.2 0.8 -0.1 1.4
Respiratory disease 1.5 3.2 7.4 1.2 -2.3 -0.4 -2.0 1.1 -2.7
Type 2 Diabetes (T2D) (2018) 0.6 1.2 2.3 1.2 0.2 1.1 -0.7 1.3 1.5
Lung FEV1/FVC ratio 1.9 9.5 15.9 4.0 -3.9 -0.6 -3.4 3.5 -1.4
Lung FVC 0.4 2.1 4.1 -2.0 0.8 1.2 1.2 -1.8 -1.3
Neuroticism 0.3 0.8 2.1 -0.8 1.1 1.5 0.5 -0.6 0.4
Chronotype (morning person) 0.8 1.9 3.3 -1.6 0.9 1.8 1.5 -1.4 0.0
Hair Pigment 0.3 9.2 14.1 -3.5 3.8 0.0 3.7 -3.7 1.1
Tanning 0.1 0.6 2.5 0.7 -0.4 -1.6 -0.6 0.5 0.2
Hand grip strength (left) 1.1 2.9 12.4 -1.4 -0.8 0.9 -0.1 -1.4 -3.5
Number of treatments/medications taken 0.0 0.1 0.2 0.1 -0.2 -0.5 -0.4 0.2 0.2
Average weekly spirits intake 0.1 0.1 0.3 -0.4 -0.4 -0.1 -0.3 -0.2 -0.5
Sensitivity / hurt feelings 2.0 3.4 5.4 -2.0 1.7 2.3 2.0 -2.1 0.1
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.8 1.3 -0.5 0.1 -1.2 1.3 0.7
Hearing difficulty/problems: Yes 0.5 0.7 2.3 0.8 0.3 -0.4 -0.4 0.9 1.5
Relative age of first facial hair 0.8 1.5 6.3 -0.7 0.6 -2.5 1.1 -0.8 0.6
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 5.1 0.2 0.0 -2.3 -0.1 0.2 0.6
Ever used hormone-replacement therapy (HRT) 1.5 1.9 3.4 -1.4 1.7 0.3 1.8 -1.3 1.0
Ever had hysterectomy (womb removed) 0.4 0.4 1.0 0.7 -0.3 0.4 -0.8 1.0 -0.2
Systolic blood pressure, automated reading 0.6 1.7 5.8 0.0 -1.1 1.2 -1.0 0.8 -2.4
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 1.0 -0.2 0.4 -1.0 -0.2 -0.0 -0.3
Angina 0.3 0.4 0.8 0.7 -0.7 0.2 -0.8 0.4 -0.9
Medication for hormone replacement therapy 0.2 0.2 0.8 -0.5 0.9 0.2 0.4 -0.4 0.2
Vitamin and mineral supplements 0.4 0.5 1.5 -0.7 0.5 -0.3 0.6 -0.6 1.2
Supplements: Zinc 1.2 1.3 3.7 1.1 -0.6 1.9 -0.9 0.8 -1.1
Medication: Co-codamol 0.5 0.6 1.3 -0.7 0.1 -1.1 0.2 -1.0 -0.7
Medication: Metformin 0.3 0.4 1.0 0.8 0.3 0.1 -0.6 1.0 0.3
Diabetes (father) 0.2 0.2 0.9 0.2 0.2 0.9 -0.1 0.1 0.6
Diabetes (mother) 0.8 1.0 1.4 1.1 -0.9 -0.9 -1.2 1.1 0.7
Severe depression (siblings) 0.2 0.2 0.4 0.3 -0.7 -0.3 -0.4 0.3 -0.4
Pack years adult smoking proportion 0.6 1.0 3.2 0.7 -1.0 -1.8 -0.6 0.6 0.5
Impedance of leg (right) 1.0 4.7 7.2 -1.5 2.3 2.6 2.1 -1.4 2.7
Leg fat-free mass (left) 2.1 11.3 22.4 2.9 -3.4 -4.7 -3.4 2.8 -2.4
Trunk fat percentage 1.0 3.9 10.7 2.3 0.6 -1.2 -1.1 2.2 3.3
Hand grip strength (right) 0.6 1.7 7.4 -0.7 -0.9 1.1 -0.6 -0.7 -2.7
Townsend deprivation index at recruitment 0.2 0.3 0.7 -0.0 0.6 0.8 0.5 -0.2 0.9
Current tobacco smoking 0.6 1.1 1.5 1.1 -1.2 -1.0 -1.0 1.2 -0.3
Average weekly fortified wine intake 0.8 1.0 1.7 -1.3 1.0 -0.9 1.1 -1.1 0.3
Maternal smoking around birth 1.0 1.4 4.5 1.0 -0.9 -2.1 -1.0 0.9 0.6
Fed-up feelings 1.1 2.1 4.2 1.9 -0.8 0.1 -1.9 2.1 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.4 3.2 5.4 1.5 -2.2 -1.0 -2.3 2.0 -1.2
Relative age voice broke 0.1 0.1 0.4 0.1 0.1 -0.2 0.2 0.1 0.6
Taking other prescription medications 1.0 1.6 3.8 1.3 -0.6 -2.0 -1.1 1.3 0.8
Age when periods started (menarche) 0.3 0.6 1.5 1.2 -0.3 -0.0 -0.7 0.8 0.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.6 0.8 -0.2 0.3 -0.5 0.8 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 3.3 -1.4 1.8 -0.4 1.7 -1.4 1.5
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 3.5 -0.3 -0.1 -1.9 0.0 -0.3 -0.7
Qualifications: CSEs or equivalent 0.2 0.3 1.0 -0.5 0.3 1.0 0.3 -0.6 0.1
Serious illness, injury or assault to yourself 0.2 0.3 0.7 -0.7 0.4 -0.5 0.3 -0.4 0.8
High blood pressure 1.2 3.3 9.7 0.2 -2.5 1.2 -1.5 0.4 -3.1
Hayfever, allergic rhinitis or eczema 0.8 1.6 6.5 0.7 -1.0 -2.5 -1.0 0.5 -0.7
Multivitamins +/- minerals 0.4 0.5 1.3 -0.6 0.4 0.5 0.5 -0.8 -1.1
Stomach or abdominal pain in last month 1.3 1.6 4.3 0.2 -1.2 -1.9 -0.5 0.0 -2.1
Supplements: Glucosamine 0.6 0.7 2.8 0.8 0.3 -1.7 -0.5 0.8 0.3
Diverticular disease/diverticulitis (self-reported) 5.3 6.2 8.6 2.8 -2.9 -1.5 -2.5 2.3 -2.7
Medication: Atenolol 0.2 0.2 0.4 -0.7 -0.0 0.4 0.3 -0.7 -0.5
Medication: Levothyroxine sodium 0.3 0.6 1.1 -0.6 0.6 0.9 1.1 -0.6 0.6
Sitting height 0.8 5.8 11.0 1.5 -3.3 -2.5 -2.1 1.5 -2.9
Chronic bronchitis/emphysema (father) 3.1 3.7 5.5 2.0 -1.9 -1.9 -2.4 2.1 -1.0
High blood pressure (mother) 0.5 0.8 2.2 -0.6 -0.5 -1.5 0.5 -0.7 -1.0
Body mass index (BMI) 0.3 1.4 3.0 1.7 -0.1 -0.7 -1.1 1.6 1.1
Impedance of leg (left) 1.1 5.3 9.7 -1.6 2.6 1.9 2.5 -1.6 3.1
Leg predicted mass (left) 2.2 11.5 23.0 2.9 -3.5 -4.8 -3.4 2.8 -2.5
Trunk fat mass 0.9 4.0 6.3 2.5 -0.2 -2.0 -1.6 2.4 2.3
Waist circumference 0.4 1.5 3.4 1.5 0.3 -0.9 -0.6 1.4 1.8
Number of incorrect matches in round 0.5 0.8 1.7 -1.0 0.5 1.3 0.8 -0.9 -0.6
Past tobacco smoking 0.5 0.9 1.8 -0.9 1.4 0.6 0.9 -0.7 1.2
Alcohol usually taken with meals 0.5 0.8 2.2 -0.0 -1.0 1.5 -0.1 -0.1 -1.2
Nervous feelings 0.3 0.5 0.9 -0.9 1.0 0.1 0.7 -0.9 -0.0
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 2.4 1.1 -1.4 -0.9 -1.5 1.0 -1.4
Hearing difficulty/problems with background noise 0.1 0.2 0.5 0.5 -0.1 -0.6 -0.7 0.3 -0.0
Hair/balding pattern: Pattern 2 0.5 0.6 2.9 -0.1 -0.4 -1.7 -0.3 -0.1 -0.6
Had menopause 0.5 0.6 2.1 0.7 0.1 -1.4 -0.2 1.0 0.6
Had other major operations 2.3 2.8 9.9 0.9 -1.6 -3.1 -1.5 1.0 -0.7
Forced vital capacity (FVC) 0.4 1.7 5.7 -0.0 -1.1 -2.4 -0.9 0.2 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 4.8 -1.6 2.0 -0.5 2.2 -1.7 1.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 3.4 -0.2 0.0 -1.8 0.3 -0.1 0.2
Qualifications: None of the above 0.5 1.2 1.6 1.1 -1.2 -0.0 -1.2 1.3 -1.1
Financial difficulties in last 2 years 0.6 0.8 1.5 -1.2 0.9 -0.2 0.9 -1.2 -0.2
Mouth/teeth dental problems 0.7 1.0 2.9 1.0 -1.7 -0.7 -1.0 0.5 -0.8
Heart attack 0.1 0.1 0.3 -0.3 0.0 0.4 0.0 -0.5 -0.1
Allergy 0.9 2.1 3.5 -1.3 1.8 1.1 1.9 -1.1 1.5
Pain all over the body in last month 0.6 0.6 3.6 0.0 0.2 -1.9 -0.3 -0.1 0.0
Diabetes (self-reported) 0.3 0.4 1.1 -0.1 1.1 0.4 0.3 -0.0 1.0
Hayfever/allergic rhinitis (self-reported) 0.9 1.1 2.2 0.8 -1.2 -0.6 -1.3 0.7 -1.5
Medication: Ramipril 0.5 0.6 1.0 1.0 -0.4 0.9 -1.0 0.8 -0.2
Medication: Simvastatin 0.2 0.2 1.3 -0.1 -0.1 1.1 -0.1 -0.2 0.2
Fluid intelligence score 1.1 2.2 3.8 1.8 -1.7 -0.3 -1.8 1.9 -0.2
Illnesses of siblings 0.2 0.2 0.6 0.8 0.1 0.6 -0.5 0.4 -0.3
Neuroticism score 0.2 0.5 1.2 -0.7 1.1 0.4 0.6 -0.7 0.3
Weight 1.1 5.5 9.9 2.6 -1.9 -3.1 -2.5 2.5 -0.3
Impedance of arm (right) 0.3 1.3 4.2 -0.6 1.3 0.4 1.2 -0.5 2.0
Arm fat percentage (right) 0.5 2.1 5.5 1.7 0.5 -0.7 -0.8 1.6 2.3
Trunk fat-free mass 1.9 11.0 16.6 2.4 -3.9 -4.1 -3.3 2.4 -3.5
Hip circumference 1.1 4.8 8.0 2.8 -1.3 -2.6 -2.3 2.6 0.2
Time employed in main current job 1.5 1.7 2.8 -1.5 1.7 0.8 1.6 -1.2 0.9
Alcohol intake versus 10 years previously 0.4 0.5 2.0 -0.5 0.1 -1.4 0.6 -0.7 -0.2
Father’s age at death 2.3 3.2 5.0 -1.9 2.2 -0.2 2.2 -1.8 1.6
Worrier / anxious feelings 0.5 1.0 3.0 -0.9 1.7 -0.3 1.0 -1.1 -0.1
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 4.0 1.7 -0.1 -2.0 -1.6 1.7 1.4
Falls in the last year 0.6 0.8 2.9 -0.5 0.7 -1.7 0.6 -0.6 0.8
Hair/balding pattern: Pattern 3 0.8 1.2 2.4 0.7 -1.6 0.3 -0.9 0.9 -1.5
Number of live births 0.1 0.1 0.6 0.0 0.3 -0.8 0.3 0.2 0.3
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 8.8 0.4 -1.4 -3.0 -1.0 0.4 -1.8
Pulse rate 0.8 1.3 2.8 1.7 -0.6 0.5 -1.2 1.5 0.8
Happiness 0.9 1.1 1.5 1.2 -1.0 -0.6 -1.2 1.1 -1.1
Noisy workplace 0.4 0.5 2.5 0.4 -0.4 -1.6 -0.5 0.3 0.2
Qualifications: A levels/AS levels or equivalent 1.1 2.3 4.9 2.2 -1.6 0.0 -1.6 1.9 -0.5
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 2.1 1.0 -1.3 -0.2 -1.0 1.1 -1.4
Mouth/teeth dental problems: Dentures 0.5 0.8 1.8 0.8 -0.7 0.4 -0.9 0.9 -1.4
Asthma 1.0 1.9 5.6 0.6 -1.7 0.2 -1.4 0.5 -2.4
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.7 0.1 0.9 0.4 0.2 -0.1 1.3
Medication: Cholesterol lowering 0.3 0.4 1.1 -0.1 0.6 1.1 0.2 -0.3 0.9
Depression (self-reported) 0.1 0.1 0.3 0.4 0.0 -0.3 -0.0 0.5 0.4
Medication: Lansoprazole 0.5 0.6 2.4 0.5 0.6 -0.5 0.3 0.2 1.5
Prospective memory result 0.1 0.2 0.5 -0.4 0.2 -0.7 0.1 -0.4 -0.4
Lung cancer (father) 0.2 0.2 0.3 0.5 0.4 0.4 -0.5 0.5 0.5
Illnesses of mother 0.6 0.7 3.3 -0.0 0.8 1.8 0.2 -0.1 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 6.2 0.4 -1.4 -2.5 -0.9 0.3 -1.9
Pulse wave Arterial Stiffness index 1.4 1.6 3.0 1.6 -0.6 -0.8 -1.3 1.7 1.2
Impedance of arm (left) 0.5 2.3 10.2 -0.3 1.6 -0.0 1.1 -0.2 3.2
Arm fat mass (right) 0.9 3.6 5.9 2.4 -0.5 -2.1 -1.7 2.3 1.6
Trunk predicted mass 1.9 10.7 16.9 2.3 -3.8 -4.1 -3.2 2.3 -3.5
Standing height 1.5 15.3 32.3 2.9 -4.4 -5.7 -3.8 2.9 -3.0
Length of working week for main job 2.0 2.2 3.9 1.9 -1.4 -0.6 -2.0 1.7 -0.6
Exposure to tobacco smoke at home 0.2 0.3 0.6 -0.5 0.8 0.0 0.6 -0.6 0.2
Breastfed as a baby 0.7 0.8 1.7 1.3 -0.8 0.4 -1.1 1.2 -0.1
Tense / ‘highly strung’ 0.1 0.2 0.4 0.5 -0.6 -0.2 -0.5 0.3 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 5.2 0.2 1.1 -0.6 0.5 -0.0 2.3
Hair/balding pattern: Pattern 4 0.9 2.2 4.0 -1.2 2.0 1.1 1.5 -1.2 1.6
Birth weight of first child 1.2 2.3 4.4 1.5 -2.1 -0.7 -1.8 1.2 -1.4
Peak expiratory flow (PEF) 0.7 1.6 7.9 0.4 -0.7 -2.8 -0.6 0.3 -0.6
Pulse wave reflection index 1.4 1.7 2.8 1.3 -1.4 -1.7 -1.3 1.4 -0.3
Ever highly irritable/argumentative for 2 days 1.1 1.3 4.6 0.3 -0.7 -2.1 -0.8 0.8 1.1
Loud music exposure frequency 1.0 1.1 3.9 -0.6 0.6 -2.0 0.9 -0.5 0.8
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.7 0.2 -0.3 0.9 -0.2 0.1 0.2
Mouth/teeth dental problems: Bleeding gums 2.1 2.7 4.9 -1.6 1.8 2.2 1.5 -1.1 1.5
Blood clot in the leg (DVT) 0.1 0.1 0.7 0.0 0.8 0.1 0.1 -0.2 0.4
Medication: Paracetamol 0.9 1.6 2.8 -1.7 1.3 -0.1 1.5 -1.5 0.6
Headache pain in last month 1.5 2.5 4.1 -2.0 2.0 -0.2 1.8 -1.8 0.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.5 -0.9 0.8 -1.2 1.1 -0.7 -0.0
Glaucoma (self-reported) 0.9 1.0 3.4 0.0 0.3 -1.9 0.1 -0.0 1.6
Gout (self-reported) 0.2 0.2 0.6 0.3 -0.1 0.8 -0.2 0.3 0.7
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.8 -0.5 0.6 0.5 1.2 -0.4 1.3
Medication: Amlodipine 0.3 0.4 1.5 -0.3 -0.5 0.8 -0.3 -0.2 -1.2
Medication: Ventolin 100micrograms inhaler 2.9 3.8 7.5 1.6 -2.4 -0.6 -2.0 1.5 -2.7
Birth weight 0.7 1.5 5.2 -0.6 -1.5 -0.8 -0.6 -0.3 -2.3
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.1 0.8 -1.0 -0.3 -1.1 0.9 0.0
High blood pressure (siblings) 0.7 1.1 1.8 -1.2 -0.3 -1.1 0.7 -1.1 -1.3
Forced vital capacity (FVC), Best measure 0.5 1.8 5.7 -0.2 -1.1 -2.4 -0.6 -0.1 -1.9
Body fat percentage 0.8 3.2 11.5 1.7 1.1 -0.8 -0.5 1.6 3.4
Leg fat percentage (right) 0.6 2.2 9.2 0.9 1.4 0.8 0.1 0.9 3.0
Arm fat-free mass (right) 1.4 7.1 13.8 2.5 -2.6 -3.7 -2.8 2.4 -1.4
Exposure to tobacco smoke outside home 0.5 0.6 1.1 -0.9 0.7 -1.0 0.9 -0.6 -0.1
Comparative body size at age 10 0.7 1.9 4.7 -1.5 0.9 2.2 1.1 -1.5 -0.0
Number of full brothers 1.0 1.2 2.2 1.5 -0.9 -0.9 -1.1 1.3 -0.6
Worry too long after embarrassment 0.4 0.7 1.5 -0.3 1.1 0.7 0.8 -0.3 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.0 -0.5 1.0 0.0 1.0 -0.8 0.2
Wheeze or whistling in the chest in last year 1.2 2.1 3.9 1.2 -1.4 -1.5 -1.4 0.9 -2.0
Number of children fathered 0.2 0.2 0.4 -0.4 0.5 -0.2 0.6 -0.4 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 2.0 -1.1 0.5 -0.3 0.8 -1.4 -0.4
Age at first live birth 0.6 1.0 2.8 0.5 -1.7 -0.2 -0.9 0.7 -1.3
Pulse wave peak to peak time 1.7 2.0 3.9 -1.9 0.6 0.4 1.5 -2.0 -1.4
Health satisfaction 1.8 2.3 4.1 1.6 -1.5 -1.7 -2.0 1.6 -0.3
Shortness of breath walking on level ground 0.6 0.7 2.2 0.6 -1.0 0.0 -0.8 0.4 -1.5
Qualifications: College or University degree 0.4 1.2 4.6 0.8 -0.4 -2.1 -0.2 0.7 1.1
Eye problems/disorders: None of the above 0.7 0.8 1.4 1.1 -1.2 -0.1 -0.7 0.9 -0.8
Mouth/teeth dental problems: Loose teeth 0.2 0.3 1.3 -0.4 0.1 1.1 0.3 -0.3 0.1
Emphysema/chronic bronchitis 2.1 2.4 3.3 1.6 -1.5 1.8 -1.5 1.5 -1.2
Medication for pain relief, constipation, heartburn 0.1 0.2 0.3 0.6 -0.1 -0.3 -0.3 0.6 0.3
Neck or shoulder pain in last month 0.8 1.2 2.1 -1.2 1.2 1.4 0.9 -0.7 0.7
Medication: Blood pressure 0.7 1.2 2.0 0.9 -1.4 0.9 -1.4 0.8 -1.0
Angina (self-reported) 0.2 0.2 0.5 0.4 -0.4 0.3 -0.5 0.2 -0.7
Migraine (self-reported) 0.8 1.0 2.1 -1.5 0.8 -1.1 1.1 -0.9 -0.0
Medication: Ibuprofen 0.7 0.8 1.9 -1.0 1.4 0.2 0.9 -1.1 0.4
Medication: Allopurinol 0.3 0.4 0.6 0.8 -0.7 -0.3 -0.8 0.7 -0.2
Medication: Omeprazole 0.2 0.2 1.1 -0.3 -0.4 0.3 -0.0 -0.2 -1.0
Medication: Seretide 50 evohaler 0.3 0.3 1.1 -0.6 -0.2 0.4 -0.0 -0.5 -1.1
Mean time to correctly identify matches 0.2 0.3 1.1 0.0 -0.2 0.6 -0.6 0.3 -1.0
Heart disease (mother) 0.6 0.7 1.0 -0.9 0.8 -0.9 1.0 -0.8 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.4 1.5 -1.2 0.8 -1.0 1.5 -0.6
Whole body fat mass 0.9 3.7 6.2 2.5 -0.4 -2.1 -1.7 2.3 1.9
Leg fat mass (right) 0.5 2.1 4.0 1.8 0.2 -1.3 -1.0 1.6 2.0
Arm predicted mass (right) 1.5 7.9 14.3 2.6 -2.9 -3.8 -2.9 2.5 -1.9
Pulse rate, automated reading 0.2 0.6 1.8 0.6 -0.1 1.4 -0.4 0.9 0.5
Alcohol intake frequency. 0.6 1.4 3.2 -1.8 0.2 -1.1 1.1 -1.6 -0.2
Comparative height size at age 10 1.3 7.3 12.8 2.0 -3.1 -3.6 -2.4 1.9 -2.8
Number of full sisters 1.8 2.1 5.3 -1.2 1.7 -2.3 1.2 -1.3 0.3
Suffer from ‘nerves’ 1.1 1.7 3.1 -1.6 1.7 -0.2 1.2 -1.8 0.1
Overall health rating 0.8 1.8 5.3 0.1 1.0 -2.3 0.3 0.0 2.1
Chest pain or discomfort 1.4 2.0 3.2 -1.7 0.7 -1.8 1.4 -1.8 -0.4
Had major operations 0.3 0.4 0.6 -0.6 0.4 -0.7 0.8 -0.6 0.6
Age at last live birth 1.2 1.8 5.2 0.2 -1.9 -1.2 -0.7 0.3 -2.3
Family relationship satisfaction 0.4 0.4 0.8 0.8 -0.7 0.4 -0.6 0.9 -0.4
Leg pain on walking 0.3 0.3 0.8 -0.6 0.7 -0.9 0.3 -0.4 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.7 3.1 -0.5 -0.1 -1.8 0.0 -0.3 -0.7
Commuting to job workplace: Car/motor vehicle 0.1 0.2 0.3 0.1 -0.5 -0.5 -0.3 0.4 -0.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.9 -0.6 1.0 0.7 0.7 -0.7 0.6
Medication: Aspirin 0.8 1.1 2.0 1.4 -0.7 -0.4 -1.4 1.3 0.3
Supplements: Vitamin C 1.1 1.3 2.9 1.3 -1.0 1.7 -0.9 1.2 -0.2
Knee pain experienced in last month 0.5 0.7 2.6 -0.6 1.0 1.6 0.4 -0.3 0.4
Hypertension (Self-reported) 1.1 2.9 9.6 -0.1 -2.3 1.0 -1.2 0.0 -3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 5.1 1.0 -0.9 -2.3 -1.1 0.8 -0.5
Illnesses of father: Heart disease 0.2 0.2 1.3 -0.3 -0.2 1.1 -0.1 0.2 -0.2
Illnesses of siblings: Diabetes 0.2 0.2 0.4 -0.5 0.6 0.6 0.2 -0.4 -0.0
Smoking status: Previous 0.3 0.5 0.9 0.7 -0.9 -0.3 -0.6 0.5 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.6 7.2 2.2 -2.6 -1.1 -2.7 2.1 -1.7
Whole body fat-free mass 1.9 11.1 20.2 2.5 -3.7 -4.5 -3.3 2.5 -3.1
Leg fat-free mass (right) 2.2 12.0 26.3 2.8 -3.5 -5.1 -3.4 2.7 -2.5
Arm fat percentage (left) 0.9 3.4 10.0 2.1 0.6 -0.9 -1.0 2.0 3.2
Average weekly red wine intake 1.2 1.8 7.5 -0.8 0.5 2.7 1.1 -1.0 0.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.6 0.5 -0.8 -1.6 -0.8 0.4 -0.7
Mood swings 0.3 0.5 1.0 -1.0 0.5 0.8 0.5 -0.8 -0.1
Loneliness, isolation 0.2 0.2 1.0 -0.1 1.0 -0.0 0.1 -0.1 0.5
Long-standing illness, disability or infirmity 0.4 0.5 1.7 0.7 -0.4 -1.3 -0.8 0.5 0.1
Ever had bowel cancer screening 1.2 1.4 3.1 1.4 -0.1 -1.8 -0.8 1.2 1.2
Diabetes diagnosed by doctor 0.3 0.4 1.5 0.3 0.8 0.3 -0.1 0.5 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 3.6 -0.1 0.2 -0.3 1.0 0.0 1.9
Friendships satisfaction 1.5 1.8 3.1 1.5 -1.5 0.4 -1.7 1.8 -0.5
Qualifications: nursing, teaching 1.3 2.1 3.7 -0.9 1.9 -1.0 1.5 -1.3 1.8
Commuting to job workplace: Walk 0.2 0.3 0.5 0.7 -0.5 -0.4 -0.7 0.4 0.3
Eye problems/disorders: Cataract 0.4 0.4 0.8 -0.7 0.9 0.6 0.3 -0.7 0.6
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.2 -1.3 1.5 0.3 1.5 -1.1 1.1
Medication for cholesterol 0.1 0.1 0.4 0.3 0.3 -0.4 -0.1 0.2 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 3.5 -0.6 -0.4 1.9 0.4 -0.7 -0.2
Back pain experienced in last month 0.2 0.2 0.5 0.1 -0.7 -0.4 -0.3 0.2 -0.7
Mineral and other dietary supplements 0.8 1.1 3.1 -1.3 0.4 1.8 0.9 -1.0 0.1
Breast cancer (self-reported) 1.2 1.5 4.3 -0.9 1.2 -2.1 1.0 -0.8 0.7
Asthma (self-reported) 0.9 1.7 4.8 0.7 -1.5 0.7 -1.4 0.6 -2.2
Osteoporosis (self-reported) 0.7 0.8 1.5 1.2 -0.6 -0.7 -0.5 1.2 1.0
Osteoarthritis (self-reported) 0.3 0.3 0.9 0.2 -0.0 -0.8 -0.4 0.5 0.9
Medication: Aspirin 0.6 0.8 1.5 1.2 -0.3 -0.6 -1.2 1.1 0.6
Medication: Gliclazide 0.4 0.4 2.2 -0.1 0.4 -1.5 -0.2 -0.2 -0.0
Illnesses of father: None of the above (group 1) 2.9 3.6 6.5 -2.4 1.7 0.8 2.3 -2.5 0.0
Smoking status: Current 0.5 0.8 1.3 0.8 -1.1 -1.0 -0.9 1.0 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.3 -0.9 1.1 -0.3 1.0 -1.1 0.9
Whole body water mass 2.0 11.7 20.5 2.7 -3.8 -4.5 -3.4 2.7 -3.0
Leg predicted mass (right) 2.2 11.7 25.4 2.8 -3.5 -5.0 -3.3 2.7 -2.5
Arm fat mass (left) 1.0 3.9 6.4 2.5 -0.5 -2.1 -1.8 2.4 1.8
Number of self-reported non-cancer illnesses 1.0 1.7 3.3 0.7 -1.8 -1.4 -1.5 0.7 -1.3
Average weekly champagne plus white wine intake 1.7 2.3 3.3 -1.4 1.3 1.8 1.8 -1.2 1.5
Miserableness 0.6 1.0 2.0 1.4 -0.8 0.0 -1.3 1.4 0.1
Guilty feelings 1.0 1.5 5.8 -0.1 1.5 0.2 0.9 0.2 2.4
Wears glasses or contact lenses 0.4 0.5 2.0 0.1 0.4 -1.4 0.0 0.2 0.8
Ever taken oral contraceptive pill 0.8 0.9 1.6 -1.2 0.5 1.1 1.1 -1.3 -0.3
Hearing aid user 0.6 0.7 1.7 0.8 -0.4 -1.0 -0.4 0.7 1.3
Mother’s age at death 0.3 0.4 0.9 -0.1 0.4 0.9 0.5 0.1 1.0
Financial situation satisfaction 0.5 0.6 1.5 0.7 -1.2 -0.4 -0.7 0.6 -0.8
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.6 0.7 -0.4 0.3 -0.3 0.8 0.3
Commuting to job workplace: Public transport 1.9 2.3 5.3 -1.1 2.3 0.8 1.6 -1.4 1.5
Eye problems/disorders: Glaucoma 0.6 0.7 1.1 -0.6 0.8 -1.0 0.8 -0.6 1.1
Medication: Blood pressure 0.5 1.0 3.4 -0.7 -1.2 0.3 -0.3 -0.6 -1.8
Pain type(s) experienced in last month: Hip pain 1.3 1.6 2.8 -1.1 1.7 -1.6 0.9 -1.3 0.8
Supplements: Fish oil (including cod liver oil) 0.5 0.6 3.1 0.3 0.5 -1.8 -0.0 0.1 0.5
High cholesterol (Self-reported) 1.3 2.3 3.7 1.8 -1.9 0.7 -1.7 1.8 -0.8
Medication: Bendroflumethiazide 0.1 0.2 0.4 -0.6 0.4 -0.1 0.6 -0.5 0.1
Medication: Paracetamol 1.5 2.4 4.2 -2.0 1.6 0.6 1.9 -1.8 0.2
Medication: Lisinopril 1.9 2.5 4.8 0.6 -2.2 1.8 -1.2 0.7 -2.2
Medication: Atorvastatin 0.5 0.6 1.2 1.1 -0.0 -0.6 -1.0 1.0 0.4
Illnesses of father: High blood pressure 1.5 1.9 3.8 1.4 -2.0 -0.4 -1.5 1.3 -1.3
Alcohol drinker status: Never 1.5 1.8 3.2 -1.8 1.1 0.5 1.5 -1.5 1.4
Ever smoked 0.8 1.5 3.1 1.0 -1.8 0.3 -1.0 0.9 -1.6
Basal metabolic rate 1.8 10.2 20.2 2.7 -3.4 -4.5 -3.2 2.6 -2.4
Leg fat percentage (left) 0.7 2.5 10.8 1.0 1.5 0.0 0.1 0.9 3.3
Arm fat-free mass (left) 1.5 7.4 13.8 2.1 -2.9 -3.7 -2.7 2.1 -2.4
Number of operations (self-reported) 0.2 0.3 1.4 0.3 -0.3 -1.2 -0.2 0.2 0.0
Average weekly beer plus cider intake 0.7 1.0 2.6 -1.2 0.9 0.4 1.6 -1.0 0.6
Irritability 0.2 0.3 0.6 0.8 -0.7 0.4 -0.7 0.5 0.0
Risk taking 0.9 1.4 2.7 -0.8 0.9 -1.6 1.2 -0.8 1.5
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 0.3 -0.6 0.5 -0.1 0.3 -0.3
Fractured/broken bones in last 5 years 3.1 4.0 6.9 -2.6 2.4 0.1 2.5 -2.2 0.7
Age started oral contraceptive pill 0.3 0.3 1.1 -0.2 0.4 1.1 0.7 -0.3 0.2
Diastolic blood pressure, automated reading 3.7 11.5 19.4 2.6 -4.4 1.8 -3.8 3.1 -3.9
Ever depressed for a whole week 0.2 0.3 0.7 -0.1 0.4 -0.9 0.3 -0.0 0.7
Unable to work because of sickness or disability 0.8 1.1 1.7 -1.1 0.9 -1.3 1.1 -1.0 0.6
Commuting to job workplace: Cycle 0.4 0.5 1.1 0.6 -1.1 -0.3 -0.3 0.8 -0.8
Myopia 0.4 0.5 1.2 1.1 -0.6 -0.1 -0.9 0.8 -0.4
Vascular/heart problems diagnosed by doctor 1.5 4.1 9.4 -0.8 2.8 -1.2 2.0 -0.9 3.1
Cholesterol lowering medication 0.6 0.9 1.6 1.3 -1.2 -0.3 -1.1 1.1 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 1.1 -0.2 -0.5 -0.2 0.1 -0.3 -1.1
Pain experienced in last month 0.5 0.8 1.7 1.3 -1.0 0.4 -0.8 1.1 -0.1
Supplements: Calcium 0.8 0.9 2.2 1.2 -0.7 -0.5 -0.9 1.5 -0.3
Basal cell carcinoma (self-reported) 0.8 1.0 1.7 1.2 -0.7 -0.8 -1.3 1.2 0.3
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 -0.2 -0.0 -0.0 -0.0 -0.4 0.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.8 -0.1 0.9 0.6 0.1 -0.2 0.2
Heart disease (siblings) 0.6 0.8 3.9 0.2 0.3 0.1 0.1 0.8 2.0
Alcohol drinker status: Previous 0.8 0.9 4.7 0.2 -0.6 -2.2 -0.3 0.1 -0.3
Pack years of smoking 0.8 1.1 2.3 1.1 -1.2 -1.5 -0.9 1.0 0.4
Impedance of whole body 0.8 3.9 12.1 -0.9 2.3 1.0 1.9 -0.9 3.5
Leg fat mass (left) 0.6 2.3 4.7 1.6 0.3 -1.8 -0.9 1.4 2.2
Arm predicted mass (left) 1.5 7.6 15.8 2.2 -2.8 -4.0 -2.7 2.2 -2.2