Hub : Genes

FAM104A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hippocampus	0.5500	0.1319	2.2e-03	0.001	NA	-0.007	NA	-0.004	3.0e-01	NA	5.1e-01	NA	4.1e-01
2	GTEx	Testis	0.2170	0.0700	5.3e-04	0.111	NA	0.107	NA	0.139	1.3e-05	NA	1.8e-05	NA	9.8e-07
3	YFS	Blood	0.0618	0.0133	2.9e-14	0.058	0.038	0.057	0.022	0.039	2.5e-18	1.4e-12	5.4e-18	6.8e-08	7.0e-13
4	TCGA	Prostate Adenocarcinoma	0.0748	0.0327	2.5e-09	0.101	0.091	0.090	NA	0.084	1.1e-10	9.1e-10	1.1e-09	NA	4.4e-09
5	TCGA	Thyroid Carcinoma	0.0300	0.0180	5.2e-03	-0.001	0.011	0.003	NA	-0.003	3.8e-01	2.9e-02	1.5e-01	NA	8.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.5	0.4	-0.5	-0.6	0.7	0.4
Bipolar Disorder or Schizophrenia	0.1	0.4	0.8	0.3	-0.6	-0.6	0.5	0.9
Depressed Affect (Nagel 2018)	0.7	1.4	3.1	-0.9	1.3	1.2	-1.8	-0.2
Depression (Nagel 2018)	0.3	0.4	0.9	0.4	-0.6	-0.6	0.5	1.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	0.0	-0.9	-0.4	0.7	-0.6
Neuroticism (Nagel 2018)	0.2	0.5	2.0	-0.6	-0.2	-0.3	-0.3	1.4
Schizophrenia (2018)	0.1	0.2	0.7	0.1	-0.3	-0.3	0.0	0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	0.8	0.3	0.7	-0.8	0.0
Worry (Nagel 2018)	1.1	2.3	3.3	0.2	-1.7	-1.8	1.5	1.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.5	-0.6	-0.0	0.3	0.2
Alzheimer’s Disease (in father)	2.7	2.9	4.0	-1.1	1.4	2.0	-2.0	-1.9
Alzheimer’s Disease (including proxy)	0.3	0.4	1.6	-1.2	-0.4	0.4	-0.1	-0.2
Crohns Disease (2017)	1.6	3.5	6.3	-0.1	-1.7	-2.1	1.9	2.5
Irritable Bowel Disease (IBD)	1.2	2.8	9.3	-0.5	-1.3	-1.5	0.8	3.0
Ulcerative Colitis (UC)	0.5	1.0	3.5	-0.4	0.2	0.2	-1.0	1.9
Major Depression (MDD)	1.8	2.2	3.9	2.0	-1.0	-1.5	1.3	1.5
Reaction Time	1.4	2.7	3.9	-1.6	2.0	1.6	-1.5	-1.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.6	1.3	-1.0	-0.4	0.7	-0.2
Breast Cancer	0.1	0.2	0.6	-0.0	-0.5	-0.3	0.8	-0.0
Ovarian Cancer	0.2	0.3	1.1	0.4	-1.1	-0.4	0.0	0.4
Prostate Cancer	0.1	0.1	0.3	0.4	0.2	0.2	-0.4	0.5
Age at First Birth	0.1	0.2	0.5	0.2	0.7	-0.0	0.2	-0.4
Bipolar Disorder (2011)	0.3	0.3	0.9	0.0	0.0	0.0	1.0	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.5	-1.2	0.5	0.2	-0.2	-0.6
Coronary Artery Disease (CAD)	0.5	0.6	1.9	-1.4	0.7	-0.1	0.2	0.5
Crohns Disease (2012)	0.3	0.4	1.2	-0.0	-0.3	-0.6	0.7	1.1
Mean Putamen Volume	0.6	0.7	1.0	0.7	-1.0	-0.8	1.0	0.5
Fasting Glucose	0.2	0.3	0.5	-0.3	0.4	0.6	-0.5	-0.7
HbA1C	0.6	0.6	1.0	0.1	0.8	0.8	-0.9	-1.0
HDL Cholesterol	0.6	0.9	1.7	1.3	1.0	0.9	-0.5	-1.0
LDL Cholesterol	0.5	0.7	2.8	1.7	-0.2	-0.6	0.1	0.7
Lupus	0.4	0.6	1.8	-0.8	0.3	0.5	-0.1	-1.3
Neuroticism (2016)	0.9	1.2	2.1	-1.4	-1.1	-1.0	1.1	0.9
Primary Biliary Cirrhosis	1.2	1.8	6.3	2.5	0.5	0.8	-1.0	-0.8
Rheumatoid Arthritis	1.2	1.7	2.2	-0.8	1.5	1.5	-1.4	-1.2
Schizophrenia (2014)	0.1	0.2	0.4	0.6	0.2	0.2	-0.7	0.6
Triglycerides	0.3	0.5	2.1	-1.5	0.5	0.4	-0.3	-0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	0.9	0.3	-0.1	0.1	0.3
Ulcerative Colitis	0.5	0.7	3.3	0.1	0.1	0.0	-0.4	1.8
Blood Eosinophil Count	0.0	0.4	1.3	-0.4	-0.1	0.5	-0.2	-1.1
Blood Platelet Count	0.6	7.2	10.6	0.5	3.0	3.2	-2.5	-3.2
Blood Red Count	2.6	25.2	38.9	-0.5	-5.4	-5.9	4.8	6.2
Blood White Count	0.6	4.5	6.1	-1.2	2.5	2.4	-1.9	-2.3
Heel T-Score	0.2	1.6	4.0	-1.0	-1.0	-1.0	0.8	2.0
BMI	0.0	0.2	0.7	-0.8	-0.3	-0.1	0.2	-0.1
Height	0.1	2.5	4.7	0.2	-2.0	-1.3	2.2	-1.6
Waist Hip Ratio (WHR)	0.2	0.7	3.3	-1.8	0.2	0.0	0.3	0.1
Systolic Blood Pressure	0.1	0.3	0.7	-0.4	0.5	0.7	-0.8	-0.1
Smoking Status	0.1	0.1	0.4	-0.6	-0.1	0.0	-0.2	-0.5
Allergy or Eczema	0.1	0.4	0.9	-0.3	0.3	0.3	-0.8	1.0
Cardiovascular Disease	0.2	0.8	2.6	-0.6	-0.6	-0.7	0.4	1.6
Hypothyroidism (self reported)	0.3	0.6	1.5	-0.8	1.2	0.7	-0.7	-0.4
Respiratory disease	0.5	1.1	2.7	-0.8	1.0	1.1	-1.6	-0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.4	-0.3	0.5	-0.3	-0.3
Lung FEV1/FVC ratio	0.0	0.2	0.6	-0.5	0.3	-0.4	-0.1	0.8
Lung FVC	0.3	1.7	3.9	0.6	-2.0	-1.2	0.8	1.5
Neuroticism	0.3	0.7	1.6	0.6	-0.9	-0.6	0.4	1.3
Chronotype (morning person)	0.8	1.9	2.8	-0.4	-1.7	-1.6	1.4	1.5
Hair Pigment	0.0	0.9	3.4	1.8	-0.7	-0.1	-0.5	0.4
Tanning	0.1	0.9	1.3	1.2	1.0	1.1	-0.9	-0.4
Hand grip strength (left)	0.7	1.7	8.2	2.9	0.5	0.4	-0.2	0.1
Number of treatments/medications taken	0.4	0.8	3.6	-1.9	0.1	0.2	-0.3	0.3
Average weekly spirits intake	0.5	0.7	0.9	-1.0	0.8	0.8	-0.9	-0.5
Sensitivity / hurt feelings	0.7	1.2	3.1	0.3	-0.8	-1.1	0.9	1.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.3	0.5	-0.9	-1.1	0.7	1.5
Hearing difficulty/problems: Yes	1.7	2.7	3.9	0.2	2.0	1.9	-1.9	-1.4
Relative age of first facial hair	0.8	1.7	4.6	-2.1	0.1	1.2	-1.5	-0.2
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	2.6	-1.6	-0.6	-1.1	1.6	0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.6	0.3	0.0	0.2	-0.6
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	0.3	-0.2	0.2	0.0	-0.2
Systolic blood pressure, automated reading	0.1	0.4	0.8	-0.7	0.2	0.7	-0.9	-0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.8	-0.2	-0.2	-0.3	0.8
Angina	0.1	0.2	0.8	-0.2	0.1	0.2	0.2	-0.9
Medication for hormone replacement therapy	0.2	0.2	0.4	0.6	0.4	0.3	-0.3	-0.5
Vitamin and mineral supplements	1.2	1.6	2.8	0.0	-1.7	-1.3	1.3	1.3
Supplements: Zinc	1.9	2.0	3.6	0.6	-1.6	-1.7	1.9	0.8
Medication: Co-codamol	1.5	1.8	2.6	-1.6	1.5	1.2	-1.1	-1.1
Medication: Metformin	0.5	0.6	1.6	-1.3	-0.8	0.0	0.7	-0.6
Diabetes (father)	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.0	0.3
Diabetes (mother)	1.1	1.4	1.8	1.1	-1.1	-1.3	1.0	1.3
Severe depression (siblings)	0.1	0.2	0.5	0.7	0.0	-0.1	0.3	-0.4
Pack years adult smoking proportion	0.2	0.3	0.9	-0.3	0.4	0.6	-0.9	-0.4
Impedance of leg (right)	0.1	0.3	1.0	0.1	1.0	0.4	-0.6	-0.1
Leg fat-free mass (left)	0.1	0.7	2.0	-0.1	-0.8	-0.7	1.4	-0.7
Trunk fat percentage	0.3	1.3	5.3	-2.3	-0.3	-0.3	0.7	-0.6
Hand grip strength (right)	0.6	1.6	7.5	2.7	0.3	0.3	-0.4	0.3
Townsend deprivation index at recruitment	0.4	0.6	1.9	-0.9	0.4	-0.1	0.5	-1.4
Current tobacco smoking	0.6	1.0	2.1	1.4	-0.8	-1.0	1.2	-0.2
Average weekly fortified wine intake	0.5	0.5	0.9	-0.9	0.4	0.9	-1.0	-0.1
Maternal smoking around birth	0.1	0.2	0.3	-0.5	0.2	-0.5	0.1	0.5
Fed-up feelings	0.2	0.4	0.8	0.5	0.6	0.9	-0.8	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.1	0.8	-0.8	-1.1	0.8	1.1
Relative age voice broke	0.8	1.2	2.3	-1.2	-0.2	1.2	-0.9	-1.5
Taking other prescription medications	0.6	0.9	3.8	-1.9	0.3	0.2	0.0	-0.7
Age when periods started (menarche)	0.2	0.4	1.1	-0.4	-0.0	0.4	-0.8	-1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.3	-1.1	0.6	0.4	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	-0.8	1.2	0.8	-0.6	-0.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.1	-0.0	-0.7	-0.6	1.1	0.9
Qualifications: CSEs or equivalent	2.0	2.7	4.4	-1.2	2.1	1.6	-1.5	-1.6
Serious illness, injury or assault to yourself	1.6	2.0	3.0	-0.8	-1.4	-1.7	1.7	1.2
High blood pressure	0.4	1.2	3.5	-1.9	-0.3	-0.6	0.5	1.3
Hayfever, allergic rhinitis or eczema	0.6	1.2	4.3	0.1	-0.8	-1.0	0.2	2.1
Multivitamins +/- minerals	1.5	1.9	3.2	0.1	1.3	1.5	-1.8	-1.5
Stomach or abdominal pain in last month	0.3	0.3	1.5	1.2	0.2	-0.1	0.2	0.3
Supplements: Glucosamine	0.9	1.2	2.5	-0.1	-1.6	-1.1	1.0	1.1
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	4.3	-0.2	-2.1	-1.7	1.4	1.2
Medication: Atenolol	0.7	0.8	3.5	-1.9	0.3	-0.1	0.4	0.6
Medication: Levothyroxine sodium	0.5	0.8	1.5	-1.2	-0.5	-0.9	0.8	0.9
Sitting height	0.1	0.8	2.0	0.3	-0.8	-1.2	1.4	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.4	0.2	-0.1	0.4	0.2
High blood pressure (mother)	0.2	0.3	0.5	0.6	-0.4	-0.6	0.5	0.7
Body mass index (BMI)	0.2	0.8	2.8	-1.7	-0.3	-0.5	0.9	-0.2
Impedance of leg (left)	0.1	0.3	0.8	0.5	0.9	0.3	-0.5	-0.1
Leg predicted mass (left)	0.1	0.7	2.0	-0.1	-0.9	-0.7	1.4	-0.7
Trunk fat mass	0.3	1.2	3.5	-1.9	-0.6	-0.6	1.1	-0.5
Waist circumference	0.6	2.4	8.8	-3.0	-0.7	-0.8	1.2	0.6
Number of incorrect matches in round	0.5	0.8	1.9	-0.2	1.4	0.8	-1.0	-0.5
Past tobacco smoking	1.4	2.5	3.5	1.6	-1.5	-1.6	1.9	1.2
Alcohol usually taken with meals	0.2	0.4	0.7	-0.6	0.5	0.7	-0.8	0.0
Nervous feelings	0.8	1.4	2.1	0.2	-1.3	-1.4	1.4	1.2
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	5.2	2.3	-1.6	-1.4	1.2	1.4
Hearing difficulty/problems with background noise	0.4	0.7	1.1	-0.9	0.7	0.8	-1.0	-0.6
Hair/balding pattern: Pattern 2	0.4	0.5	0.8	0.8	0.3	0.9	-0.8	-0.6
Had menopause	0.4	0.5	1.1	-1.0	0.5	0.5	-0.3	-1.0
Had other major operations	1.9	2.3	4.2	0.5	-1.9	-1.7	2.1	0.8
Forced vital capacity (FVC)	0.5	2.0	3.6	1.4	-1.9	-1.4	1.2	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.2	-0.9	1.1	0.8	-0.9	0.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.4	2.1	0.5	1.4	-1.4	-0.8
Qualifications: None of the above	0.1	0.1	0.6	-0.8	-0.1	-0.1	-0.0	-0.0
Financial difficulties in last 2 years	1.5	2.1	3.6	-1.1	-1.9	-1.7	1.4	0.9
Mouth/teeth dental problems	0.1	0.2	0.7	-0.3	-0.3	-0.3	0.9	-0.2
Heart attack	0.6	0.8	1.5	-1.2	0.4	0.8	-1.2	0.1
Allergy	0.6	1.4	4.5	0.5	0.8	1.2	-0.2	-2.1
Pain all over the body in last month	0.3	0.3	1.3	-0.0	-0.2	0.3	-0.1	-1.1
Diabetes (self-reported)	0.2	0.3	1.0	-1.0	-0.5	0.0	0.0	0.2
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	2.8	1.7	-0.9	-1.5	1.2	1.6
Medication: Ramipril	0.4	0.5	1.5	1.2	-0.4	0.0	-0.4	0.6
Medication: Simvastatin	0.9	1.3	2.7	-0.7	1.1	1.4	-1.6	-0.5
Fluid intelligence score	0.6	1.3	2.4	1.6	-1.3	-0.9	1.0	0.6
Illnesses of siblings	0.5	0.7	2.2	0.0	-1.5	-0.7	0.5	0.8
Neuroticism score	0.2	0.3	1.1	0.5	-0.5	-0.4	0.2	1.0
Weight	0.2	0.9	2.2	-1.1	-0.6	-0.8	1.5	-0.5
Impedance of arm (right)	0.0	0.1	0.3	-0.2	0.5	0.3	-0.5	-0.2
Arm fat percentage (right)	0.3	1.2	4.1	-2.0	-0.4	-0.7	1.0	-0.1
Trunk fat-free mass	0.1	0.6	1.7	0.4	-0.7	-0.8	1.3	-0.3
Hip circumference	0.2	0.7	2.3	-1.5	-0.1	-0.2	0.7	-0.7
Time employed in main current job	1.7	2.0	6.7	0.0	0.8	1.5	-0.5	-2.6
Alcohol intake versus 10 years previously	0.1	0.1	0.6	0.2	-0.8	0.0	0.0	-0.1
Father’s age at death	2.4	3.3	4.8	2.1	-1.6	-1.7	2.2	1.4
Worrier / anxious feelings	0.2	0.4	1.0	-0.4	-0.6	-0.6	0.5	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.5	-0.4	-0.6	-0.7	0.5	0.7
Falls in the last year	1.5	2.0	3.0	-1.1	-0.9	-1.7	1.4	1.7
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	-0.3	0.3	0.5	-0.6	-0.5
Number of live births	0.1	0.2	0.5	0.7	0.3	0.2	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	3.0	1.3	-1.7	-1.6	1.3	1.5
Pulse rate	0.5	0.8	1.4	0.1	1.2	0.9	-1.1	-0.7
Happiness	0.5	0.5	2.4	0.5	-1.6	-0.0	0.0	0.0
Noisy workplace	3.3	4.0	6.4	0.4	2.5	2.4	-1.9	-2.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.4	1.8	-0.5	-0.1	0.3	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.4	0.1	-1.2	-1.0	0.9	0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	-0.8	0.1	0.1	-0.4	0.1
Asthma	0.2	0.4	0.9	-1.0	-0.3	-0.3	-0.4	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	-0.0	-1.0	-0.7	0.9	0.4
Medication: Cholesterol lowering	0.4	0.7	2.3	-1.5	0.2	0.2	-0.6	0.9
Depression (self-reported)	1.5	1.8	3.2	-1.8	0.9	1.3	-1.2	-1.3
Medication: Lansoprazole	0.8	0.9	3.7	-1.9	0.6	0.4	-0.6	0.0
Prospective memory result	0.4	0.5	1.3	0.3	1.1	0.8	-0.8	-0.2
Lung cancer (father)	0.3	0.4	0.8	0.3	0.3	0.7	-0.5	-0.9
Illnesses of mother	0.1	0.1	0.4	-0.4	-0.2	-0.1	-0.3	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.3	1.5	-0.7	-0.8	0.7	0.8
Pulse wave Arterial Stiffness index	1.0	1.1	1.6	0.7	-1.2	-1.2	1.0	1.1
Impedance of arm (left)	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.1	-0.1
Arm fat mass (right)	0.3	1.2	2.9	-1.7	-0.6	-0.9	1.4	-0.2
Trunk predicted mass	0.1	0.6	1.8	0.5	-0.7	-0.7	1.3	-0.4
Standing height	0.1	1.1	2.1	1.2	-0.9	-0.9	1.5	-0.8
Length of working week for main job	1.1	1.3	2.0	-0.4	-1.3	-1.4	1.4	0.7
Exposure to tobacco smoke at home	0.4	0.4	1.3	-1.2	0.5	0.6	-0.2	0.1
Breastfed as a baby	0.3	0.3	1.1	-1.0	-0.0	0.5	-0.5	-0.3
Tense / ‘highly strung’	0.7	1.1	2.5	1.6	-1.0	-0.9	1.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.0	-0.2	-0.5	-0.4	-0.1	1.4
Hair/balding pattern: Pattern 4	0.3	0.7	1.6	1.2	-0.6	-0.3	0.1	1.2
Birth weight of first child	0.1	0.2	0.5	0.5	-0.1	0.5	-0.7	-0.3
Peak expiratory flow (PEF)	1.5	3.5	6.4	0.3	-2.1	-2.0	1.6	2.5
Pulse wave reflection index	1.7	2.1	3.6	-0.7	-1.8	-1.5	0.9	1.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	0.2	-1.1	-0.5	1.1	-0.0
Loud music exposure frequency	3.0	3.3	8.1	2.8	1.7	1.4	-1.4	-1.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.2	-0.4	-0.2	0.3	-0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.0	0.9	0.5	1.0	-0.9	-0.9
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.6	0.3	0.3	-0.8	0.5
Medication: Paracetamol	0.6	1.0	3.2	1.8	-0.8	-0.7	0.9	0.2
Headache pain in last month	0.1	0.2	0.4	0.7	0.1	0.4	-0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.7	1.4	0.9	0.8	-0.2	-1.9
Glaucoma (self-reported)	0.1	0.1	0.2	0.5	-0.1	-0.2	0.3	0.1
Gout (self-reported)	3.1	4.3	5.8	0.8	2.3	2.2	-2.2	-2.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.0	-1.0	-0.2	-0.7	0.9	0.7
Medication: Amlodipine	0.7	0.9	2.9	-1.7	0.8	0.6	-0.6	0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.8	-0.8	0.8	0.8	-0.6	-1.3
Birth weight	0.4	0.8	2.6	0.6	0.6	0.9	0.2	-1.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	-0.9	-0.7	-0.3	0.4	-0.1
High blood pressure (siblings)	0.6	0.9	2.3	0.8	1.5	0.8	-0.5	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.8	2.8	1.7	-0.8	-0.6	0.6	0.2
Body fat percentage	0.3	1.3	4.9	-2.2	-0.3	-0.5	0.9	-0.4
Leg fat percentage (right)	0.3	1.2	4.8	-2.2	-0.2	-0.5	0.9	-0.1
Arm fat-free mass (right)	0.1	0.8	2.2	0.1	-0.9	-0.9	1.5	-0.3
Exposure to tobacco smoke outside home	0.3	0.5	1.6	0.5	1.2	0.6	-0.3	-0.1
Comparative body size at age 10	0.6	1.5	3.9	0.6	1.1	1.2	-0.8	-2.0
Number of full brothers	0.2	0.2	0.4	0.6	0.4	0.3	-0.3	-0.4
Worry too long after embarrassment	1.6	2.7	5.1	0.2	-1.8	-1.7	1.4	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.1	-0.0	-0.3	-0.3	0.2	1.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	-0.1	0.8	0.3	-0.6	0.2
Number of children fathered	0.1	0.1	0.5	-0.7	0.0	-0.1	0.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	-0.4	-0.7	-0.5	0.5	0.6
Age at first live birth	0.4	0.7	3.3	1.8	-0.0	0.1	-0.1	0.3
Pulse wave peak to peak time	0.9	1.1	1.4	-0.7	1.2	1.2	-0.8	-1.2
Health satisfaction	0.4	0.6	2.0	-1.4	-0.9	0.1	-0.2	-0.3
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.7	-0.3	0.3	-0.3	-0.6
Qualifications: College or University degree	0.1	0.2	0.6	0.2	0.3	0.8	-0.4	-0.4
Eye problems/disorders: None of the above	0.1	0.2	0.5	0.2	-0.4	-0.4	0.7	0.1
Mouth/teeth dental problems: Loose teeth	1.2	1.4	5.7	2.4	0.0	-0.6	-0.0	0.9
Emphysema/chronic bronchitis	0.5	0.5	0.8	-0.1	0.7	0.9	-0.7	-0.9
Medication for pain relief, constipation, heartburn	0.3	0.4	0.9	-0.4	1.0	0.6	-0.8	-0.4
Neck or shoulder pain in last month	0.6	0.9	2.0	-0.5	-0.9	-1.0	0.7	1.4
Medication: Blood pressure	0.2	0.4	1.6	-1.3	0.2	0.4	-0.4	0.0
Angina (self-reported)	0.2	0.3	1.0	-0.5	0.2	0.3	0.1	-1.0
Migraine (self-reported)	0.4	0.5	1.5	0.3	-1.2	-0.7	0.1	0.7
Medication: Ibuprofen	0.1	0.1	0.4	0.2	-0.2	0.0	0.3	-0.6
Medication: Allopurinol	1.2	1.5	3.1	-0.2	1.8	1.3	-1.5	-0.8
Medication: Omeprazole	0.7	0.8	1.4	-1.2	-1.0	-0.6	1.1	0.3
Medication: Seretide 50 evohaler	1.9	2.2	10.4	-3.2	0.5	0.2	0.2	-0.4
Mean time to correctly identify matches	1.1	2.0	2.4	-1.5	1.6	1.5	-1.4	-1.2
Heart disease (mother)	1.1	1.4	2.6	0.3	1.6	1.2	-1.3	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.3	3.9	6.2	-2.0	1.5	2.2	-2.5	-1.5
Whole body fat mass	0.3	1.1	2.7	-1.6	-0.6	-0.8	1.3	-0.3
Leg fat mass (right)	0.3	1.1	3.8	-1.9	-0.3	-0.4	1.0	-0.5
Arm predicted mass (right)	0.2	0.9	2.6	-0.1	-0.9	-1.0	1.6	-0.3
Pulse rate, automated reading	0.1	0.3	1.2	-0.3	0.3	0.2	0.2	-1.1
Alcohol intake frequency.	0.3	0.6	1.5	-1.2	0.9	0.6	-0.5	-0.4
Comparative height size at age 10	0.1	0.5	1.5	-0.1	0.3	-0.3	0.9	-1.2
Number of full sisters	0.4	0.5	1.6	0.6	0.2	0.5	-0.4	-1.3
Suffer from ‘nerves’	0.1	0.2	0.4	-0.6	-0.5	-0.5	0.5	-0.3
Overall health rating	0.4	0.9	4.1	-2.0	0.1	-0.1	0.4	-0.5
Chest pain or discomfort	1.0	1.5	4.9	-2.2	-0.9	-0.6	1.1	-0.0
Had major operations	0.2	0.2	0.6	-0.4	0.1	-0.3	0.8	-0.2
Age at last live birth	1.2	1.7	2.6	1.1	1.4	1.4	-1.6	-0.8
Family relationship satisfaction	0.3	0.4	0.9	0.9	-1.0	0.4	-0.3	-0.4
Leg pain on walking	0.8	1.0	2.0	0.9	-1.4	-1.1	0.8	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	-0.2	-0.5	-1.0	1.0	0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	0.3	0.7	0.9	-1.2	-0.1
Illness, injury, bereavement, stress in last 2 years	5.4	6.6	9.5	2.2	2.5	3.1	-2.6	-2.3
Medication: Aspirin	0.2	0.2	0.5	-0.3	0.2	0.6	-0.4	-0.7
Supplements: Vitamin C	0.7	0.8	1.5	0.5	-0.9	-1.2	1.1	0.7
Knee pain experienced in last month	0.8	1.2	1.7	-1.0	-1.3	-1.3	1.1	0.8
Hypertension (Self-reported)	0.4	1.2	3.6	-1.9	-0.2	-0.6	0.6	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.1	-0.9	-0.2	-0.8	0.9	1.0
Illnesses of father: Heart disease	0.1	0.2	0.7	-0.3	0.4	-0.1	-0.0	0.8
Illnesses of siblings: Diabetes	0.1	0.1	0.5	-0.3	0.2	0.1	0.0	-0.7
Smoking status: Previous	0.9	1.4	2.3	-1.5	1.0	1.1	-1.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.1	1.2	-1.2	-1.2	1.8	0.8
Whole body fat-free mass	0.1	0.7	2.1	0.3	-0.8	-0.8	1.5	-0.4
Leg fat-free mass (right)	0.2	0.8	2.0	0.2	-1.0	-0.8	1.4	-0.7
Arm fat percentage (left)	0.3	1.2	2.9	-1.7	-0.7	-0.9	1.3	-0.0
Average weekly red wine intake	1.5	2.2	3.1	-0.7	-1.4	-1.7	1.6	1.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.6	-0.2	0.5	0.3	0.2	-1.3
Mood swings	0.3	0.6	1.1	1.0	0.6	0.2	-1.0	0.8
Loneliness, isolation	1.6	2.3	3.4	-1.9	-1.8	-1.3	1.5	0.9
Long-standing illness, disability or infirmity	0.9	1.4	1.7	-0.9	1.1	1.3	-1.2	-1.3
Ever had bowel cancer screening	2.7	3.2	4.7	-1.0	-2.1	-2.1	2.2	1.2
Diabetes diagnosed by doctor	0.4	0.7	3.2	-1.8	-0.1	0.4	-0.4	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	0.8	0.7	0.3	-0.7	0.0
Friendships satisfaction	0.4	0.5	1.7	0.4	-1.3	0.4	-0.5	-0.1
Qualifications: nursing, teaching	0.8	1.3	2.0	1.2	1.0	1.4	-1.0	-1.0
Commuting to job workplace: Walk	0.7	0.8	1.1	1.0	-1.1	-1.0	0.5	0.8
Eye problems/disorders: Cataract	0.3	0.3	1.1	0.1	0.4	0.5	-1.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.1	-0.3	0.8	0.7	-1.4	0.4
Medication for cholesterol	0.5	0.8	1.7	0.8	-1.3	-1.0	0.6	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	-0.2	0.7	1.0	-0.5	-0.2
Back pain experienced in last month	0.4	0.6	1.5	-0.2	-0.6	-0.9	0.7	1.2
Mineral and other dietary supplements	0.6	0.8	1.3	0.4	1.1	1.0	-0.9	-0.7
Breast cancer (self-reported)	0.3	0.4	0.9	-0.9	-0.2	-0.3	0.9	-0.5
Asthma (self-reported)	0.2	0.4	1.1	-1.1	-0.1	-0.2	-0.5	0.8
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.2	0.1	-0.2	0.4	-0.6
Osteoarthritis (self-reported)	0.7	1.0	1.3	0.7	0.6	1.1	-1.1	-1.1
Medication: Aspirin	0.2	0.2	0.5	-0.7	0.1	0.5	-0.2	-0.5
Medication: Gliclazide	0.1	0.2	0.7	-0.8	-0.2	0.1	0.1	0.2
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	0.9	-0.7	-0.3	-0.0	0.1
Smoking status: Current	0.6	1.0	1.6	1.2	-1.0	-1.1	1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.9	1.7	0.1	-0.4	0.4	-0.1
Whole body water mass	0.1	0.8	2.2	0.1	-0.9	-0.8	1.5	-0.4
Leg predicted mass (right)	0.2	0.9	2.2	0.2	-1.0	-0.8	1.5	-0.6
Arm fat mass (left)	0.3	1.3	2.7	-1.7	-0.7	-1.0	1.5	-0.2
Number of self-reported non-cancer illnesses	0.9	1.5	6.2	-2.5	-0.4	-0.6	0.7	0.6
Average weekly champagne plus white wine intake	0.4	0.6	1.6	-0.3	0.5	0.8	-1.3	-0.5
Miserableness	0.5	0.9	2.5	-1.6	0.7	0.6	-1.0	0.2
Guilty feelings	0.3	0.5	1.0	0.3	0.6	0.9	-1.0	0.2
Wears glasses or contact lenses	0.6	0.7	1.5	-1.2	-0.9	-0.5	0.3	1.1
Ever taken oral contraceptive pill	5.7	6.3	9.9	-0.2	-2.7	-3.0	2.4	3.1
Hearing aid user	1.1	1.2	2.4	1.5	0.7	1.1	-1.5	0.1
Mother’s age at death	0.1	0.1	0.4	0.0	-0.3	-0.2	0.6	-0.1
Financial situation satisfaction	0.6	0.7	2.8	0.5	-1.7	-0.4	0.4	0.5
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.1	0.7	1.3	1.8	-1.7	-1.1
Commuting to job workplace: Public transport	0.4	0.4	1.1	-0.3	-0.3	-0.7	1.0	0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.0	0.7	0.7	-0.5	-0.3
Medication: Blood pressure	0.5	1.0	3.8	-1.9	0.9	0.5	-0.5	0.0
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	0.1	-0.2	0.3	-0.4	0.6
Supplements: Fish oil (including cod liver oil)	1.4	1.9	2.8	-1.2	-1.7	-1.4	1.3	1.2
High cholesterol (Self-reported)	0.4	0.7	1.3	0.5	1.2	0.9	-1.0	-0.2
Medication: Bendroflumethiazide	0.6	1.0	4.4	-2.1	0.6	0.1	0.2	-0.1
Medication: Paracetamol	0.9	1.5	7.2	2.7	-0.3	-0.0	0.2	-0.1
Medication: Lisinopril	0.1	0.1	0.3	-0.6	0.0	-0.1	0.2	-0.1
Medication: Atorvastatin	0.5	0.6	0.8	-0.9	0.7	0.8	-0.8	-0.6
Illnesses of father: High blood pressure	1.1	1.4	2.1	0.0	-1.0	-1.5	1.4	1.4
Alcohol drinker status: Never	1.3	1.6	4.3	-2.1	-0.9	-0.8	1.3	-0.7
Ever smoked	1.8	3.1	4.6	-0.5	2.1	2.0	-2.2	-1.5
Basal metabolic rate	0.1	0.8	2.2	-0.1	-0.8	-0.8	1.5	-0.5
Leg fat percentage (left)	0.2	0.9	3.3	-1.8	-0.2	-0.5	0.8	-0.1
Arm fat-free mass (left)	0.1	0.6	1.7	-0.4	-0.6	-0.7	1.3	-0.6
Number of operations (self-reported)	0.4	0.5	1.4	-0.7	-0.6	-0.4	1.2	-0.5
Average weekly beer plus cider intake	1.3	1.8	4.3	0.3	1.1	1.5	-1.1	-2.1
Irritability	0.1	0.2	0.5	0.7	0.2	0.2	-0.6	0.4
Risk taking	0.0	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.1	-2.0	-1.3	-0.9	0.7	0.6
Fractured/broken bones in last 5 years	0.4	0.5	1.1	-0.6	1.0	0.7	-0.8	0.3
Age started oral contraceptive pill	0.2	0.3	0.8	-0.9	-0.3	-0.0	-0.5	0.4
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.5	0.3	0.3	-0.2	-0.4
Ever depressed for a whole week	0.6	0.7	2.4	1.6	-0.5	-0.1	-0.5	0.8
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.7	-0.5	-0.4	0.6	-0.6
Commuting to job workplace: Cycle	1.0	1.2	2.7	0.9	-1.6	-0.9	0.9	0.9
Myopia	2.2	3.2	5.6	1.1	-1.5	-2.4	2.0	1.7
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.1	1.4	0.3	0.4	-0.3	-1.0
Cholesterol lowering medication	1.0	1.4	2.6	-0.3	1.6	1.3	-1.1	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-0.2	-0.9	-0.7	1.0	0.1
Pain experienced in last month	0.1	0.2	0.4	0.6	0.2	-0.2	0.3	0.5
Supplements: Calcium	0.3	0.4	0.5	0.6	-0.6	-0.7	0.7	0.5
Basal cell carcinoma (self-reported)	2.6	3.1	5.6	0.1	-1.8	-2.4	1.9	1.8
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	-0.9	0.7	1.1	-1.4	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	-0.5	-0.0	0.0	-0.5	1.0
Heart disease (siblings)	0.4	0.4	0.8	-0.4	0.7	-0.7	0.5	0.9
Alcohol drinker status: Previous	1.0	1.1	3.5	0.3	-1.0	-0.9	0.4	1.9
Pack years of smoking	0.2	0.3	1.2	-1.1	0.1	0.3	-0.6	-0.2
Impedance of whole body	0.0	0.1	0.3	0.4	0.6	0.2	-0.3	-0.1
Leg fat mass (left)	0.2	0.9	2.6	-1.6	-0.4	-0.6	1.1	-0.3
Arm predicted mass (left)	0.1	0.3	0.8	-0.2	-0.0	-0.3	0.9	-0.7