Hub : Genes

FAM104A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hippocampus 0.5500 0.1319 2.2e-03 0.001 NA -0.007 NA -0.004 3.0e-01 NA 5.1e-01 NA 4.1e-01
2 GTEx Testis 0.2170 0.0700 5.3e-04 0.111 NA 0.107 NA 0.139 1.3e-05 NA 1.8e-05 NA 9.8e-07
3 YFS Blood 0.0618 0.0133 2.9e-14 0.058 0.038 0.057 0.022 0.039 2.5e-18 1.4e-12 5.4e-18 6.8e-08 7.0e-13
4 TCGA Prostate Adenocarcinoma 0.0748 0.0327 2.5e-09 0.101 0.091 0.090 NA 0.084 1.1e-10 9.1e-10 1.1e-09 NA 4.4e-09
5 TCGA Thyroid Carcinoma 0.0300 0.0180 5.2e-03 -0.001 0.011 0.003 NA -0.003 3.8e-01 2.9e-02 1.5e-01 NA 8.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 0.5 0.4 -0.5 -0.6 0.7 0.4
Bipolar Disorder or Schizophrenia 0.1 0.4 0.8 0.3 -0.6 -0.6 0.5 0.9
Depressed Affect (Nagel 2018) 0.7 1.4 3.1 -0.9 1.3 1.2 -1.8 -0.2
Depression (Nagel 2018) 0.3 0.4 0.9 0.4 -0.6 -0.6 0.5 1.0
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.9 0.0 -0.9 -0.4 0.7 -0.6
Neuroticism (Nagel 2018) 0.2 0.5 2.0 -0.6 -0.2 -0.3 -0.3 1.4
Schizophrenia (2018) 0.1 0.2 0.7 0.1 -0.3 -0.3 0.0 0.8
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 0.8 0.3 0.7 -0.8 0.0
Worry (Nagel 2018) 1.1 2.3 3.3 0.2 -1.7 -1.8 1.5 1.8
Alzheimer’s Disease (in mother) 0.1 0.1 0.3 -0.5 -0.6 -0.0 0.3 0.2
Alzheimer’s Disease (in father) 2.7 2.9 4.0 -1.1 1.4 2.0 -2.0 -1.9
Alzheimer’s Disease (including proxy) 0.3 0.4 1.6 -1.2 -0.4 0.4 -0.1 -0.2
Crohns Disease (2017) 1.6 3.5 6.3 -0.1 -1.7 -2.1 1.9 2.5
Irritable Bowel Disease (IBD) 1.2 2.8 9.3 -0.5 -1.3 -1.5 0.8 3.0
Ulcerative Colitis (UC) 0.5 1.0 3.5 -0.4 0.2 0.2 -1.0 1.9
Major Depression (MDD) 1.8 2.2 3.9 2.0 -1.0 -1.5 1.3 1.5
Reaction Time 1.4 2.7 3.9 -1.6 2.0 1.6 -1.5 -1.4
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.6 1.3 -1.0 -0.4 0.7 -0.2
Breast Cancer 0.1 0.2 0.6 -0.0 -0.5 -0.3 0.8 -0.0
Ovarian Cancer 0.2 0.3 1.1 0.4 -1.1 -0.4 0.0 0.4
Prostate Cancer 0.1 0.1 0.3 0.4 0.2 0.2 -0.4 0.5
Age at First Birth 0.1 0.2 0.5 0.2 0.7 -0.0 0.2 -0.4
Bipolar Disorder (2011) 0.3 0.3 0.9 0.0 0.0 0.0 1.0 0.8
Body Mass Index (BMI) (2010) 0.3 0.4 1.5 -1.2 0.5 0.2 -0.2 -0.6
Coronary Artery Disease (CAD) 0.5 0.6 1.9 -1.4 0.7 -0.1 0.2 0.5
Crohns Disease (2012) 0.3 0.4 1.2 -0.0 -0.3 -0.6 0.7 1.1
Mean Putamen Volume 0.6 0.7 1.0 0.7 -1.0 -0.8 1.0 0.5
Fasting Glucose 0.2 0.3 0.5 -0.3 0.4 0.6 -0.5 -0.7
HbA1C 0.6 0.6 1.0 0.1 0.8 0.8 -0.9 -1.0
HDL Cholesterol 0.6 0.9 1.7 1.3 1.0 0.9 -0.5 -1.0
LDL Cholesterol 0.5 0.7 2.8 1.7 -0.2 -0.6 0.1 0.7
Lupus 0.4 0.6 1.8 -0.8 0.3 0.5 -0.1 -1.3
Neuroticism (2016) 0.9 1.2 2.1 -1.4 -1.1 -1.0 1.1 0.9
Primary Biliary Cirrhosis 1.2 1.8 6.3 2.5 0.5 0.8 -1.0 -0.8
Rheumatoid Arthritis 1.2 1.7 2.2 -0.8 1.5 1.5 -1.4 -1.2
Schizophrenia (2014) 0.1 0.2 0.4 0.6 0.2 0.2 -0.7 0.6
Triglycerides 0.3 0.5 2.1 -1.5 0.5 0.4 -0.3 -0.3
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.8 0.9 0.3 -0.1 0.1 0.3
Ulcerative Colitis 0.5 0.7 3.3 0.1 0.1 0.0 -0.4 1.8
Blood Eosinophil Count 0.0 0.4 1.3 -0.4 -0.1 0.5 -0.2 -1.1
Blood Platelet Count 0.6 7.2 10.6 0.5 3.0 3.2 -2.5 -3.2
Blood Red Count 2.6 25.2 38.9 -0.5 -5.4 -5.9 4.8 6.2
Blood White Count 0.6 4.5 6.1 -1.2 2.5 2.4 -1.9 -2.3
Heel T-Score 0.2 1.6 4.0 -1.0 -1.0 -1.0 0.8 2.0
BMI 0.0 0.2 0.7 -0.8 -0.3 -0.1 0.2 -0.1
Height 0.1 2.5 4.7 0.2 -2.0 -1.3 2.2 -1.6
Waist Hip Ratio (WHR) 0.2 0.7 3.3 -1.8 0.2 0.0 0.3 0.1
Systolic Blood Pressure 0.1 0.3 0.7 -0.4 0.5 0.7 -0.8 -0.1
Smoking Status 0.1 0.1 0.4 -0.6 -0.1 0.0 -0.2 -0.5
Allergy or Eczema 0.1 0.4 0.9 -0.3 0.3 0.3 -0.8 1.0
Cardiovascular Disease 0.2 0.8 2.6 -0.6 -0.6 -0.7 0.4 1.6
Hypothyroidism (self reported) 0.3 0.6 1.5 -0.8 1.2 0.7 -0.7 -0.4
Respiratory disease 0.5 1.1 2.7 -0.8 1.0 1.1 -1.6 -0.4
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.2 -0.4 -0.3 0.5 -0.3 -0.3
Lung FEV1/FVC ratio 0.0 0.2 0.6 -0.5 0.3 -0.4 -0.1 0.8
Lung FVC 0.3 1.7 3.9 0.6 -2.0 -1.2 0.8 1.5
Neuroticism 0.3 0.7 1.6 0.6 -0.9 -0.6 0.4 1.3
Chronotype (morning person) 0.8 1.9 2.8 -0.4 -1.7 -1.6 1.4 1.5
Hair Pigment 0.0 0.9 3.4 1.8 -0.7 -0.1 -0.5 0.4
Tanning 0.1 0.9 1.3 1.2 1.0 1.1 -0.9 -0.4
Hand grip strength (left) 0.7 1.7 8.2 2.9 0.5 0.4 -0.2 0.1
Number of treatments/medications taken 0.4 0.8 3.6 -1.9 0.1 0.2 -0.3 0.3
Average weekly spirits intake 0.5 0.7 0.9 -1.0 0.8 0.8 -0.9 -0.5
Sensitivity / hurt feelings 0.7 1.2 3.1 0.3 -0.8 -1.1 0.9 1.7
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.3 0.5 -0.9 -1.1 0.7 1.5
Hearing difficulty/problems: Yes 1.7 2.7 3.9 0.2 2.0 1.9 -1.9 -1.4
Relative age of first facial hair 0.8 1.7 4.6 -2.1 0.1 1.2 -1.5 -0.2
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 2.6 -1.6 -0.6 -1.1 1.6 0.9
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 -0.6 0.3 0.0 0.2 -0.6
Ever had hysterectomy (womb removed) 0.0 0.0 0.1 0.3 -0.2 0.2 0.0 -0.2
Systolic blood pressure, automated reading 0.1 0.4 0.8 -0.7 0.2 0.7 -0.9 -0.2
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.7 0.8 -0.2 -0.2 -0.3 0.8
Angina 0.1 0.2 0.8 -0.2 0.1 0.2 0.2 -0.9
Medication for hormone replacement therapy 0.2 0.2 0.4 0.6 0.4 0.3 -0.3 -0.5
Vitamin and mineral supplements 1.2 1.6 2.8 0.0 -1.7 -1.3 1.3 1.3
Supplements: Zinc 1.9 2.0 3.6 0.6 -1.6 -1.7 1.9 0.8
Medication: Co-codamol 1.5 1.8 2.6 -1.6 1.5 1.2 -1.1 -1.1
Medication: Metformin 0.5 0.6 1.6 -1.3 -0.8 0.0 0.7 -0.6
Diabetes (father) 0.1 0.1 0.2 -0.4 -0.4 -0.1 0.0 0.3
Diabetes (mother) 1.1 1.4 1.8 1.1 -1.1 -1.3 1.0 1.3
Severe depression (siblings) 0.1 0.2 0.5 0.7 0.0 -0.1 0.3 -0.4
Pack years adult smoking proportion 0.2 0.3 0.9 -0.3 0.4 0.6 -0.9 -0.4
Impedance of leg (right) 0.1 0.3 1.0 0.1 1.0 0.4 -0.6 -0.1
Leg fat-free mass (left) 0.1 0.7 2.0 -0.1 -0.8 -0.7 1.4 -0.7
Trunk fat percentage 0.3 1.3 5.3 -2.3 -0.3 -0.3 0.7 -0.6
Hand grip strength (right) 0.6 1.6 7.5 2.7 0.3 0.3 -0.4 0.3
Townsend deprivation index at recruitment 0.4 0.6 1.9 -0.9 0.4 -0.1 0.5 -1.4
Current tobacco smoking 0.6 1.0 2.1 1.4 -0.8 -1.0 1.2 -0.2
Average weekly fortified wine intake 0.5 0.5 0.9 -0.9 0.4 0.9 -1.0 -0.1
Maternal smoking around birth 0.1 0.2 0.3 -0.5 0.2 -0.5 0.1 0.5
Fed-up feelings 0.2 0.4 0.8 0.5 0.6 0.9 -0.8 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.1 0.8 -0.8 -1.1 0.8 1.1
Relative age voice broke 0.8 1.2 2.3 -1.2 -0.2 1.2 -0.9 -1.5
Taking other prescription medications 0.6 0.9 3.8 -1.9 0.3 0.2 0.0 -0.7
Age when periods started (menarche) 0.2 0.4 1.1 -0.4 -0.0 0.4 -0.8 -1.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.3 -1.1 0.6 0.4 -0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.4 -0.8 1.2 0.8 -0.6 -0.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.1 -0.0 -0.7 -0.6 1.1 0.9
Qualifications: CSEs or equivalent 2.0 2.7 4.4 -1.2 2.1 1.6 -1.5 -1.6
Serious illness, injury or assault to yourself 1.6 2.0 3.0 -0.8 -1.4 -1.7 1.7 1.2
High blood pressure 0.4 1.2 3.5 -1.9 -0.3 -0.6 0.5 1.3
Hayfever, allergic rhinitis or eczema 0.6 1.2 4.3 0.1 -0.8 -1.0 0.2 2.1
Multivitamins +/- minerals 1.5 1.9 3.2 0.1 1.3 1.5 -1.8 -1.5
Stomach or abdominal pain in last month 0.3 0.3 1.5 1.2 0.2 -0.1 0.2 0.3
Supplements: Glucosamine 0.9 1.2 2.5 -0.1 -1.6 -1.1 1.0 1.1
Diverticular disease/diverticulitis (self-reported) 1.8 2.2 4.3 -0.2 -2.1 -1.7 1.4 1.2
Medication: Atenolol 0.7 0.8 3.5 -1.9 0.3 -0.1 0.4 0.6
Medication: Levothyroxine sodium 0.5 0.8 1.5 -1.2 -0.5 -0.9 0.8 0.9
Sitting height 0.1 0.8 2.0 0.3 -0.8 -1.2 1.4 -0.2
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 -0.4 0.2 -0.1 0.4 0.2
High blood pressure (mother) 0.2 0.3 0.5 0.6 -0.4 -0.6 0.5 0.7
Body mass index (BMI) 0.2 0.8 2.8 -1.7 -0.3 -0.5 0.9 -0.2
Impedance of leg (left) 0.1 0.3 0.8 0.5 0.9 0.3 -0.5 -0.1
Leg predicted mass (left) 0.1 0.7 2.0 -0.1 -0.9 -0.7 1.4 -0.7
Trunk fat mass 0.3 1.2 3.5 -1.9 -0.6 -0.6 1.1 -0.5
Waist circumference 0.6 2.4 8.8 -3.0 -0.7 -0.8 1.2 0.6
Number of incorrect matches in round 0.5 0.8 1.9 -0.2 1.4 0.8 -1.0 -0.5
Past tobacco smoking 1.4 2.5 3.5 1.6 -1.5 -1.6 1.9 1.2
Alcohol usually taken with meals 0.2 0.4 0.7 -0.6 0.5 0.7 -0.8 0.0
Nervous feelings 0.8 1.4 2.1 0.2 -1.3 -1.4 1.4 1.2
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 5.2 2.3 -1.6 -1.4 1.2 1.4
Hearing difficulty/problems with background noise 0.4 0.7 1.1 -0.9 0.7 0.8 -1.0 -0.6
Hair/balding pattern: Pattern 2 0.4 0.5 0.8 0.8 0.3 0.9 -0.8 -0.6
Had menopause 0.4 0.5 1.1 -1.0 0.5 0.5 -0.3 -1.0
Had other major operations 1.9 2.3 4.2 0.5 -1.9 -1.7 2.1 0.8
Forced vital capacity (FVC) 0.5 2.0 3.6 1.4 -1.9 -1.4 1.2 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.2 -0.9 1.1 0.8 -0.9 0.1
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 4.4 2.1 0.5 1.4 -1.4 -0.8
Qualifications: None of the above 0.1 0.1 0.6 -0.8 -0.1 -0.1 -0.0 -0.0
Financial difficulties in last 2 years 1.5 2.1 3.6 -1.1 -1.9 -1.7 1.4 0.9
Mouth/teeth dental problems 0.1 0.2 0.7 -0.3 -0.3 -0.3 0.9 -0.2
Heart attack 0.6 0.8 1.5 -1.2 0.4 0.8 -1.2 0.1
Allergy 0.6 1.4 4.5 0.5 0.8 1.2 -0.2 -2.1
Pain all over the body in last month 0.3 0.3 1.3 -0.0 -0.2 0.3 -0.1 -1.1
Diabetes (self-reported) 0.2 0.3 1.0 -1.0 -0.5 0.0 0.0 0.2
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 2.8 1.7 -0.9 -1.5 1.2 1.6
Medication: Ramipril 0.4 0.5 1.5 1.2 -0.4 0.0 -0.4 0.6
Medication: Simvastatin 0.9 1.3 2.7 -0.7 1.1 1.4 -1.6 -0.5
Fluid intelligence score 0.6 1.3 2.4 1.6 -1.3 -0.9 1.0 0.6
Illnesses of siblings 0.5 0.7 2.2 0.0 -1.5 -0.7 0.5 0.8
Neuroticism score 0.2 0.3 1.1 0.5 -0.5 -0.4 0.2 1.0
Weight 0.2 0.9 2.2 -1.1 -0.6 -0.8 1.5 -0.5
Impedance of arm (right) 0.0 0.1 0.3 -0.2 0.5 0.3 -0.5 -0.2
Arm fat percentage (right) 0.3 1.2 4.1 -2.0 -0.4 -0.7 1.0 -0.1
Trunk fat-free mass 0.1 0.6 1.7 0.4 -0.7 -0.8 1.3 -0.3
Hip circumference 0.2 0.7 2.3 -1.5 -0.1 -0.2 0.7 -0.7
Time employed in main current job 1.7 2.0 6.7 0.0 0.8 1.5 -0.5 -2.6
Alcohol intake versus 10 years previously 0.1 0.1 0.6 0.2 -0.8 0.0 0.0 -0.1
Father’s age at death 2.4 3.3 4.8 2.1 -1.6 -1.7 2.2 1.4
Worrier / anxious feelings 0.2 0.4 1.0 -0.4 -0.6 -0.6 0.5 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.5 -0.4 -0.6 -0.7 0.5 0.7
Falls in the last year 1.5 2.0 3.0 -1.1 -0.9 -1.7 1.4 1.7
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 -0.3 0.3 0.5 -0.6 -0.5
Number of live births 0.1 0.2 0.5 0.7 0.3 0.2 -0.3 -0.3
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 3.0 1.3 -1.7 -1.6 1.3 1.5
Pulse rate 0.5 0.8 1.4 0.1 1.2 0.9 -1.1 -0.7
Happiness 0.5 0.5 2.4 0.5 -1.6 -0.0 0.0 0.0
Noisy workplace 3.3 4.0 6.4 0.4 2.5 2.4 -1.9 -2.0
Qualifications: A levels/AS levels or equivalent 0.3 0.7 3.4 1.8 -0.5 -0.1 0.3 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.4 0.1 -1.2 -1.0 0.9 0.7
Mouth/teeth dental problems: Dentures 0.1 0.2 0.6 -0.8 0.1 0.1 -0.4 0.1
Asthma 0.2 0.4 0.9 -1.0 -0.3 -0.3 -0.4 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.0 -0.0 -1.0 -0.7 0.9 0.4
Medication: Cholesterol lowering 0.4 0.7 2.3 -1.5 0.2 0.2 -0.6 0.9
Depression (self-reported) 1.5 1.8 3.2 -1.8 0.9 1.3 -1.2 -1.3
Medication: Lansoprazole 0.8 0.9 3.7 -1.9 0.6 0.4 -0.6 0.0
Prospective memory result 0.4 0.5 1.3 0.3 1.1 0.8 -0.8 -0.2
Lung cancer (father) 0.3 0.4 0.8 0.3 0.3 0.7 -0.5 -0.9
Illnesses of mother 0.1 0.1 0.4 -0.4 -0.2 -0.1 -0.3 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.3 1.5 -0.7 -0.8 0.7 0.8
Pulse wave Arterial Stiffness index 1.0 1.1 1.6 0.7 -1.2 -1.2 1.0 1.1
Impedance of arm (left) 0.0 0.0 0.0 0.2 -0.1 -0.0 -0.1 -0.1
Arm fat mass (right) 0.3 1.2 2.9 -1.7 -0.6 -0.9 1.4 -0.2
Trunk predicted mass 0.1 0.6 1.8 0.5 -0.7 -0.7 1.3 -0.4
Standing height 0.1 1.1 2.1 1.2 -0.9 -0.9 1.5 -0.8
Length of working week for main job 1.1 1.3 2.0 -0.4 -1.3 -1.4 1.4 0.7
Exposure to tobacco smoke at home 0.4 0.4 1.3 -1.2 0.5 0.6 -0.2 0.1
Breastfed as a baby 0.3 0.3 1.1 -1.0 -0.0 0.5 -0.5 -0.3
Tense / ‘highly strung’ 0.7 1.1 2.5 1.6 -1.0 -0.9 1.1 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.0 -0.2 -0.5 -0.4 -0.1 1.4
Hair/balding pattern: Pattern 4 0.3 0.7 1.6 1.2 -0.6 -0.3 0.1 1.2
Birth weight of first child 0.1 0.2 0.5 0.5 -0.1 0.5 -0.7 -0.3
Peak expiratory flow (PEF) 1.5 3.5 6.4 0.3 -2.1 -2.0 1.6 2.5
Pulse wave reflection index 1.7 2.1 3.6 -0.7 -1.8 -1.5 0.9 1.9
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.3 0.2 -1.1 -0.5 1.1 -0.0
Loud music exposure frequency 3.0 3.3 8.1 2.8 1.7 1.4 -1.4 -1.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 0.2 -0.4 -0.2 0.3 -0.4
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.0 0.9 0.5 1.0 -0.9 -0.9
Blood clot in the leg (DVT) 0.2 0.3 0.6 -0.6 0.3 0.3 -0.8 0.5
Medication: Paracetamol 0.6 1.0 3.2 1.8 -0.8 -0.7 0.9 0.2
Headache pain in last month 0.1 0.2 0.4 0.7 0.1 0.4 -0.5 -0.1
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 3.7 1.4 0.9 0.8 -0.2 -1.9
Glaucoma (self-reported) 0.1 0.1 0.2 0.5 -0.1 -0.2 0.3 0.1
Gout (self-reported) 3.1 4.3 5.8 0.8 2.3 2.2 -2.2 -2.4
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.0 -1.0 -0.2 -0.7 0.9 0.7
Medication: Amlodipine 0.7 0.9 2.9 -1.7 0.8 0.6 -0.6 0.5
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.8 -0.8 0.8 0.8 -0.6 -1.3
Birth weight 0.4 0.8 2.6 0.6 0.6 0.9 0.2 -1.6
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.9 -0.9 -0.7 -0.3 0.4 -0.1
High blood pressure (siblings) 0.6 0.9 2.3 0.8 1.5 0.8 -0.5 -0.7
Forced vital capacity (FVC), Best measure 0.2 0.8 2.8 1.7 -0.8 -0.6 0.6 0.2
Body fat percentage 0.3 1.3 4.9 -2.2 -0.3 -0.5 0.9 -0.4
Leg fat percentage (right) 0.3 1.2 4.8 -2.2 -0.2 -0.5 0.9 -0.1
Arm fat-free mass (right) 0.1 0.8 2.2 0.1 -0.9 -0.9 1.5 -0.3
Exposure to tobacco smoke outside home 0.3 0.5 1.6 0.5 1.2 0.6 -0.3 -0.1
Comparative body size at age 10 0.6 1.5 3.9 0.6 1.1 1.2 -0.8 -2.0
Number of full brothers 0.2 0.2 0.4 0.6 0.4 0.3 -0.3 -0.4
Worry too long after embarrassment 1.6 2.7 5.1 0.2 -1.8 -1.7 1.4 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.1 -0.0 -0.3 -0.3 0.2 1.4
Wheeze or whistling in the chest in last year 0.1 0.2 0.6 -0.1 0.8 0.3 -0.6 0.2
Number of children fathered 0.1 0.1 0.5 -0.7 0.0 -0.1 0.2 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.5 -0.4 -0.7 -0.5 0.5 0.6
Age at first live birth 0.4 0.7 3.3 1.8 -0.0 0.1 -0.1 0.3
Pulse wave peak to peak time 0.9 1.1 1.4 -0.7 1.2 1.2 -0.8 -1.2
Health satisfaction 0.4 0.6 2.0 -1.4 -0.9 0.1 -0.2 -0.3
Shortness of breath walking on level ground 0.2 0.2 0.5 -0.7 -0.3 0.3 -0.3 -0.6
Qualifications: College or University degree 0.1 0.2 0.6 0.2 0.3 0.8 -0.4 -0.4
Eye problems/disorders: None of the above 0.1 0.2 0.5 0.2 -0.4 -0.4 0.7 0.1
Mouth/teeth dental problems: Loose teeth 1.2 1.4 5.7 2.4 0.0 -0.6 -0.0 0.9
Emphysema/chronic bronchitis 0.5 0.5 0.8 -0.1 0.7 0.9 -0.7 -0.9
Medication for pain relief, constipation, heartburn 0.3 0.4 0.9 -0.4 1.0 0.6 -0.8 -0.4
Neck or shoulder pain in last month 0.6 0.9 2.0 -0.5 -0.9 -1.0 0.7 1.4
Medication: Blood pressure 0.2 0.4 1.6 -1.3 0.2 0.4 -0.4 0.0
Angina (self-reported) 0.2 0.3 1.0 -0.5 0.2 0.3 0.1 -1.0
Migraine (self-reported) 0.4 0.5 1.5 0.3 -1.2 -0.7 0.1 0.7
Medication: Ibuprofen 0.1 0.1 0.4 0.2 -0.2 0.0 0.3 -0.6
Medication: Allopurinol 1.2 1.5 3.1 -0.2 1.8 1.3 -1.5 -0.8
Medication: Omeprazole 0.7 0.8 1.4 -1.2 -1.0 -0.6 1.1 0.3
Medication: Seretide 50 evohaler 1.9 2.2 10.4 -3.2 0.5 0.2 0.2 -0.4
Mean time to correctly identify matches 1.1 2.0 2.4 -1.5 1.6 1.5 -1.4 -1.2
Heart disease (mother) 1.1 1.4 2.6 0.3 1.6 1.2 -1.3 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.3 3.9 6.2 -2.0 1.5 2.2 -2.5 -1.5
Whole body fat mass 0.3 1.1 2.7 -1.6 -0.6 -0.8 1.3 -0.3
Leg fat mass (right) 0.3 1.1 3.8 -1.9 -0.3 -0.4 1.0 -0.5
Arm predicted mass (right) 0.2 0.9 2.6 -0.1 -0.9 -1.0 1.6 -0.3
Pulse rate, automated reading 0.1 0.3 1.2 -0.3 0.3 0.2 0.2 -1.1
Alcohol intake frequency. 0.3 0.6 1.5 -1.2 0.9 0.6 -0.5 -0.4
Comparative height size at age 10 0.1 0.5 1.5 -0.1 0.3 -0.3 0.9 -1.2
Number of full sisters 0.4 0.5 1.6 0.6 0.2 0.5 -0.4 -1.3
Suffer from ‘nerves’ 0.1 0.2 0.4 -0.6 -0.5 -0.5 0.5 -0.3
Overall health rating 0.4 0.9 4.1 -2.0 0.1 -0.1 0.4 -0.5
Chest pain or discomfort 1.0 1.5 4.9 -2.2 -0.9 -0.6 1.1 -0.0
Had major operations 0.2 0.2 0.6 -0.4 0.1 -0.3 0.8 -0.2
Age at last live birth 1.2 1.7 2.6 1.1 1.4 1.4 -1.6 -0.8
Family relationship satisfaction 0.3 0.4 0.9 0.9 -1.0 0.4 -0.3 -0.4
Leg pain on walking 0.8 1.0 2.0 0.9 -1.4 -1.1 0.8 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.1 -0.2 -0.5 -1.0 1.0 0.3
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.3 0.3 0.7 0.9 -1.2 -0.1
Illness, injury, bereavement, stress in last 2 years 5.4 6.6 9.5 2.2 2.5 3.1 -2.6 -2.3
Medication: Aspirin 0.2 0.2 0.5 -0.3 0.2 0.6 -0.4 -0.7
Supplements: Vitamin C 0.7 0.8 1.5 0.5 -0.9 -1.2 1.1 0.7
Knee pain experienced in last month 0.8 1.2 1.7 -1.0 -1.3 -1.3 1.1 0.8
Hypertension (Self-reported) 0.4 1.2 3.6 -1.9 -0.2 -0.6 0.6 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.1 -0.9 -0.2 -0.8 0.9 1.0
Illnesses of father: Heart disease 0.1 0.2 0.7 -0.3 0.4 -0.1 -0.0 0.8
Illnesses of siblings: Diabetes 0.1 0.1 0.5 -0.3 0.2 0.1 0.0 -0.7
Smoking status: Previous 0.9 1.4 2.3 -1.5 1.0 1.1 -1.4 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 3.1 1.2 -1.2 -1.2 1.8 0.8
Whole body fat-free mass 0.1 0.7 2.1 0.3 -0.8 -0.8 1.5 -0.4
Leg fat-free mass (right) 0.2 0.8 2.0 0.2 -1.0 -0.8 1.4 -0.7
Arm fat percentage (left) 0.3 1.2 2.9 -1.7 -0.7 -0.9 1.3 -0.0
Average weekly red wine intake 1.5 2.2 3.1 -0.7 -1.4 -1.7 1.6 1.8
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.6 -0.2 0.5 0.3 0.2 -1.3
Mood swings 0.3 0.6 1.1 1.0 0.6 0.2 -1.0 0.8
Loneliness, isolation 1.6 2.3 3.4 -1.9 -1.8 -1.3 1.5 0.9
Long-standing illness, disability or infirmity 0.9 1.4 1.7 -0.9 1.1 1.3 -1.2 -1.3
Ever had bowel cancer screening 2.7 3.2 4.7 -1.0 -2.1 -2.1 2.2 1.2
Diabetes diagnosed by doctor 0.4 0.7 3.2 -1.8 -0.1 0.4 -0.4 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.7 0.8 0.7 0.3 -0.7 0.0
Friendships satisfaction 0.4 0.5 1.7 0.4 -1.3 0.4 -0.5 -0.1
Qualifications: nursing, teaching 0.8 1.3 2.0 1.2 1.0 1.4 -1.0 -1.0
Commuting to job workplace: Walk 0.7 0.8 1.1 1.0 -1.1 -1.0 0.5 0.8
Eye problems/disorders: Cataract 0.3 0.3 1.1 0.1 0.4 0.5 -1.0 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.1 -0.3 0.8 0.7 -1.4 0.4
Medication for cholesterol 0.5 0.8 1.7 0.8 -1.3 -1.0 0.6 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.0 -0.2 0.7 1.0 -0.5 -0.2
Back pain experienced in last month 0.4 0.6 1.5 -0.2 -0.6 -0.9 0.7 1.2
Mineral and other dietary supplements 0.6 0.8 1.3 0.4 1.1 1.0 -0.9 -0.7
Breast cancer (self-reported) 0.3 0.4 0.9 -0.9 -0.2 -0.3 0.9 -0.5
Asthma (self-reported) 0.2 0.4 1.1 -1.1 -0.1 -0.2 -0.5 0.8
Osteoporosis (self-reported) 0.1 0.1 0.3 -0.2 0.1 -0.2 0.4 -0.6
Osteoarthritis (self-reported) 0.7 1.0 1.3 0.7 0.6 1.1 -1.1 -1.1
Medication: Aspirin 0.2 0.2 0.5 -0.7 0.1 0.5 -0.2 -0.5
Medication: Gliclazide 0.1 0.2 0.7 -0.8 -0.2 0.1 0.1 0.2
Illnesses of father: None of the above (group 1) 0.2 0.3 0.8 0.9 -0.7 -0.3 -0.0 0.1
Smoking status: Current 0.6 1.0 1.6 1.2 -1.0 -1.1 1.3 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.9 1.7 0.1 -0.4 0.4 -0.1
Whole body water mass 0.1 0.8 2.2 0.1 -0.9 -0.8 1.5 -0.4
Leg predicted mass (right) 0.2 0.9 2.2 0.2 -1.0 -0.8 1.5 -0.6
Arm fat mass (left) 0.3 1.3 2.7 -1.7 -0.7 -1.0 1.5 -0.2
Number of self-reported non-cancer illnesses 0.9 1.5 6.2 -2.5 -0.4 -0.6 0.7 0.6
Average weekly champagne plus white wine intake 0.4 0.6 1.6 -0.3 0.5 0.8 -1.3 -0.5
Miserableness 0.5 0.9 2.5 -1.6 0.7 0.6 -1.0 0.2
Guilty feelings 0.3 0.5 1.0 0.3 0.6 0.9 -1.0 0.2
Wears glasses or contact lenses 0.6 0.7 1.5 -1.2 -0.9 -0.5 0.3 1.1
Ever taken oral contraceptive pill 5.7 6.3 9.9 -0.2 -2.7 -3.0 2.4 3.1
Hearing aid user 1.1 1.2 2.4 1.5 0.7 1.1 -1.5 0.1
Mother’s age at death 0.1 0.1 0.4 0.0 -0.3 -0.2 0.6 -0.1
Financial situation satisfaction 0.6 0.7 2.8 0.5 -1.7 -0.4 0.4 0.5
Tinnitus: Yes, now most or all of the time 1.6 1.9 3.1 0.7 1.3 1.8 -1.7 -1.1
Commuting to job workplace: Public transport 0.4 0.4 1.1 -0.3 -0.3 -0.7 1.0 0.6
Eye problems/disorders: Glaucoma 0.2 0.3 0.5 0.0 0.7 0.7 -0.5 -0.3
Medication: Blood pressure 0.5 1.0 3.8 -1.9 0.9 0.5 -0.5 0.0
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.4 0.1 -0.2 0.3 -0.4 0.6
Supplements: Fish oil (including cod liver oil) 1.4 1.9 2.8 -1.2 -1.7 -1.4 1.3 1.2
High cholesterol (Self-reported) 0.4 0.7 1.3 0.5 1.2 0.9 -1.0 -0.2
Medication: Bendroflumethiazide 0.6 1.0 4.4 -2.1 0.6 0.1 0.2 -0.1
Medication: Paracetamol 0.9 1.5 7.2 2.7 -0.3 -0.0 0.2 -0.1
Medication: Lisinopril 0.1 0.1 0.3 -0.6 0.0 -0.1 0.2 -0.1
Medication: Atorvastatin 0.5 0.6 0.8 -0.9 0.7 0.8 -0.8 -0.6
Illnesses of father: High blood pressure 1.1 1.4 2.1 0.0 -1.0 -1.5 1.4 1.4
Alcohol drinker status: Never 1.3 1.6 4.3 -2.1 -0.9 -0.8 1.3 -0.7
Ever smoked 1.8 3.1 4.6 -0.5 2.1 2.0 -2.2 -1.5
Basal metabolic rate 0.1 0.8 2.2 -0.1 -0.8 -0.8 1.5 -0.5
Leg fat percentage (left) 0.2 0.9 3.3 -1.8 -0.2 -0.5 0.8 -0.1
Arm fat-free mass (left) 0.1 0.6 1.7 -0.4 -0.6 -0.7 1.3 -0.6
Number of operations (self-reported) 0.4 0.5 1.4 -0.7 -0.6 -0.4 1.2 -0.5
Average weekly beer plus cider intake 1.3 1.8 4.3 0.3 1.1 1.5 -1.1 -2.1
Irritability 0.1 0.2 0.5 0.7 0.2 0.2 -0.6 0.4
Risk taking 0.0 0.0 0.0 0.1 -0.2 0.2 -0.2 -0.1
Ever had prostate specific antigen (PSA) test 1.3 1.5 4.1 -2.0 -1.3 -0.9 0.7 0.6
Fractured/broken bones in last 5 years 0.4 0.5 1.1 -0.6 1.0 0.7 -0.8 0.3
Age started oral contraceptive pill 0.2 0.3 0.8 -0.9 -0.3 -0.0 -0.5 0.4
Diastolic blood pressure, automated reading 0.0 0.1 0.2 -0.5 0.3 0.3 -0.2 -0.4
Ever depressed for a whole week 0.6 0.7 2.4 1.6 -0.5 -0.1 -0.5 0.8
Unable to work because of sickness or disability 0.2 0.3 0.5 -0.7 -0.5 -0.4 0.6 -0.6
Commuting to job workplace: Cycle 1.0 1.2 2.7 0.9 -1.6 -0.9 0.9 0.9
Myopia 2.2 3.2 5.6 1.1 -1.5 -2.4 2.0 1.7
Vascular/heart problems diagnosed by doctor 0.3 0.7 2.1 1.4 0.3 0.4 -0.3 -1.0
Cholesterol lowering medication 1.0 1.4 2.6 -0.3 1.6 1.3 -1.1 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.0 -0.2 -0.9 -0.7 1.0 0.1
Pain experienced in last month 0.1 0.2 0.4 0.6 0.2 -0.2 0.3 0.5
Supplements: Calcium 0.3 0.4 0.5 0.6 -0.6 -0.7 0.7 0.5
Basal cell carcinoma (self-reported) 2.6 3.1 5.6 0.1 -1.8 -2.4 1.9 1.8
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.0 -0.9 0.7 1.1 -1.4 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.9 -0.5 -0.0 0.0 -0.5 1.0
Heart disease (siblings) 0.4 0.4 0.8 -0.4 0.7 -0.7 0.5 0.9
Alcohol drinker status: Previous 1.0 1.1 3.5 0.3 -1.0 -0.9 0.4 1.9
Pack years of smoking 0.2 0.3 1.2 -1.1 0.1 0.3 -0.6 -0.2
Impedance of whole body 0.0 0.1 0.3 0.4 0.6 0.2 -0.3 -0.1
Leg fat mass (left) 0.2 0.9 2.6 -1.6 -0.4 -0.6 1.1 -0.3
Arm predicted mass (left) 0.1 0.3 0.8 -0.2 -0.0 -0.3 0.9 -0.7