Hub : Genes

FAM107B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.3680 0.0640 1.9e-07 0.310 NA 0.253 NA 0.301 1.4e-17 NA 3.4e-14 NA 5.2e-17
2 GTEx Artery Tibial 0.2694 0.0551 5.1e-06 0.201 NA 0.143 NA 0.202 1.1e-15 NA 2.4e-11 NA 9.3e-16
3 GTEx Muscle Skeletal 0.1328 0.0394 9.8e-04 0.010 NA 0.024 NA 0.010 3.0e-02 NA 1.7e-03 NA 3.3e-02
4 GTEx Nerve Tibial 0.1213 0.0427 4.2e-03 -0.004 NA -0.004 NA -0.004 9.5e-01 NA 9.8e-01 NA 9.0e-01
5 NTR Blood 0.0660 0.0157 5.5e-07 0.016 0.022 0.031 0.034 0.036 5.2e-06 7.6e-08 2.1e-10 2.6e-11 1.1e-11
6 ROSMAP Brain Pre-frontal Cortex 0.1840 0.0413 2.9e-06 0.066 0.067 0.082 0.112 0.071 6.3e-09 5.8e-09 9.3e-11 3.6e-14 1.7e-09
7 YFS Blood 0.1496 0.0229 0.0e+00 0.063 0.081 0.096 0.100 0.098 1.1e-19 3.8e-25 1.1e-29 5.7e-31 1.8e-30
8 TCGA Head and Neck Squamous Cell Carcinoma 0.0461 0.0205 6.3e-03 0.011 0.016 0.006 NA 0.023 1.9e-02 6.2e-03 5.6e-02 NA 1.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 1.3 2.1 7.9 0.4 0.8 0.2 -2.8 -1.4 0.2 0.1 2.4
Bipolar Disorder or Schizophrenia 0.8 1.9 7.2 -1.5 -1.3 -0.0 -2.7 -1.0 1.0 0.7 1.3
Depressed Affect (Nagel 2018) 0.5 1.0 1.9 -1.2 -1.2 -1.4 0.7 -0.4 1.2 0.8 0.2
Depression (Nagel 2018) 0.7 1.1 3.5 -1.9 -1.8 -0.5 0.6 0.0 1.0 0.3 0.4
Intelligence (Savage-Jansen 2018) 0.8 2.6 7.6 1.7 1.8 -1.2 0.3 1.6 -2.8 -1.5 -1.0
Neuroticism (Nagel 2018) 0.6 1.4 4.0 -0.8 -0.8 -1.3 2.0 -1.3 1.5 -0.2 0.2
Schizophrenia (2018) 0.8 1.7 5.3 -2.2 -2.3 -0.2 -1.2 -0.1 1.2 0.8 -0.3
Schizophrenia vs Biploar Disorder 1.1 1.5 3.3 -1.7 -1.8 -1.1 0.3 -1.2 1.7 -0.1 0.4
Worry (Nagel 2018) 0.9 1.8 6.1 -0.5 -0.5 -0.7 1.5 -2.5 2.1 -0.6 0.8
Alzheimer’s Disease (in mother) 0.7 0.8 2.0 -0.7 -0.8 -0.5 -0.7 -1.2 1.1 -1.4 -0.2
Alzheimer’s Disease (in father) 1.8 2.0 6.1 -1.0 -1.2 -2.5 -0.2 -0.2 1.2 -0.0 -2.4
Alzheimer’s Disease (including proxy) 1.1 1.5 3.3 -0.8 -0.9 -1.7 -0.5 -1.1 1.0 -1.8 -1.4
Crohns Disease (2017) 0.2 0.4 1.0 -0.2 -0.2 0.9 -0.1 -1.0 -0.5 -0.7 -0.8
Irritable Bowel Disease (IBD) 0.2 0.5 2.2 0.2 0.1 0.6 -1.5 0.4 -0.7 0.7 -0.2
Ulcerative Colitis (UC) 0.7 1.3 3.7 1.0 0.8 0.5 -1.9 1.5 -0.3 1.6 0.4
Major Depression (MDD) 0.8 0.9 2.3 -1.1 -1.1 -0.6 0.4 0.0 1.5 1.4 0.4
Reaction Time 1.1 2.1 5.5 -1.2 -1.0 -1.3 -0.3 -2.3 0.7 -2.0 -1.4
Verbal and Numeric Reasoning (VNR) 0.5 1.1 4.2 0.1 0.2 -1.2 0.2 2.0 -1.6 -0.1 -0.8
Breast Cancer 0.3 0.7 1.9 0.8 0.8 1.2 1.4 0.2 -0.7 -0.3 -0.4
Ovarian Cancer 0.8 1.0 2.1 -0.7 -0.3 1.2 -1.4 -0.6 -0.6 1.1 1.4
Prostate Cancer 0.3 0.5 0.9 -0.7 -0.8 0.9 0.6 0.2 0.7 0.9 -0.0
Age at First Birth 1.1 1.5 2.4 1.6 1.4 1.3 1.4 -0.8 1.2 0.5 1.3
Bipolar Disorder (2011) 1.9 1.9 5.5 -0.9 -0.8 -0.9 -2.4 0.3 1.0 2.1 -1.3
Body Mass Index (BMI) (2010) 0.6 0.8 3.8 0.1 0.0 1.0 0.4 0.3 -1.9 -1.2 0.3
Coronary Artery Disease (CAD) 1.2 1.4 3.6 -1.4 -1.3 -0.8 -0.6 -0.4 1.9 1.7 0.1
Crohns Disease (2012) 0.2 0.3 0.9 -0.0 0.1 -0.6 -0.3 -1.0 0.3 -0.8 -0.8
Mean Putamen Volume 0.5 0.6 1.6 -1.2 -1.2 0.8 -0.3 0.1 0.1 -0.1 -0.9
Fasting Glucose 1.1 1.3 2.1 -1.2 -1.0 -0.9 -1.5 -1.1 1.3 1.3 -0.6
HbA1C 0.6 0.6 1.6 0.8 0.9 -0.7 0.7 -0.4 -0.9 -1.3 0.6
HDL Cholesterol 0.4 0.6 1.9 0.6 0.6 0.9 -0.8 -0.3 -0.3 -1.4 0.6
LDL Cholesterol 0.4 0.6 3.1 -0.3 -0.4 -0.3 0.9 0.7 -0.2 0.3 1.8
Lupus 0.7 1.0 2.2 0.6 0.6 1.1 0.8 1.0 0.4 -1.5 -1.5
Neuroticism (2016) 0.3 0.5 1.7 -0.1 -0.4 -1.3 -0.5 -1.2 0.0 0.1 -0.3
Primary Biliary Cirrhosis 0.2 0.3 0.8 -0.1 -0.3 -0.1 -0.1 0.6 0.9 0.9 -0.4
Rheumatoid Arthritis 1.0 1.4 5.0 1.4 1.3 -1.3 -0.7 2.2 -0.6 0.7 -0.2
Schizophrenia (2014) 0.6 1.4 3.9 -2.0 -2.0 0.1 -0.6 -1.0 1.3 0.3 0.3
Triglycerides 0.9 1.5 4.4 -0.8 -0.7 -1.5 -0.4 1.3 1.2 2.1 -0.6
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.6 0.7 0.8 1.6 0.1 -0.4 1.0 0.3 1.2
Ulcerative Colitis 1.2 1.8 8.0 -0.5 -0.7 -1.5 -2.8 1.0 -0.3 1.5 -0.4
Blood Eosinophil Count 0.6 4.9 8.1 2.2 2.4 1.8 -1.8 2.9 -2.7 1.7 2.1
Blood Platelet Count 0.7 7.7 32.0 1.2 1.1 1.1 -1.7 2.7 0.1 3.9 5.7
Blood Red Count 0.1 0.7 3.8 0.2 0.1 0.4 0.4 -0.5 -0.7 -1.9 -1.0
Blood White Count 0.3 2.1 6.3 -1.5 -1.5 -0.5 -0.7 -2.2 0.3 -0.3 2.5
Heel T-Score 0.3 2.3 4.7 2.1 2.1 0.7 0.7 1.4 -2.2 1.4 0.5
BMI 0.8 4.4 9.8 -3.0 -3.1 -1.5 -2.2 -0.9 0.6 -1.3 -2.5
Height 0.1 1.2 5.4 -0.6 -0.5 -0.3 0.0 -0.5 -2.3 -1.4 -1.1
Waist Hip Ratio (WHR) 0.5 2.2 7.1 0.4 0.5 -0.1 -0.1 -1.7 2.3 1.2 2.7
Systolic Blood Pressure 0.1 0.6 2.7 0.9 0.8 -0.2 1.6 -0.5 0.2 0.7 -0.2
Smoking Status 0.9 2.2 7.1 0.7 0.7 1.6 -0.7 -1.3 2.7 0.2 2.2
Allergy or Eczema 0.2 0.5 1.4 0.6 0.8 -0.3 -1.2 0.7 -0.6 0.3 -0.5
Cardiovascular Disease 0.2 0.7 1.9 -0.9 -1.1 -0.5 0.8 -0.7 1.4 0.8 0.1
Hypothyroidism (self reported) 0.6 1.4 5.6 -0.3 -0.1 0.5 -0.8 -0.6 -1.4 -1.4 -2.4
Respiratory disease 0.7 1.5 4.0 -0.4 -0.2 -0.0 -1.9 0.4 0.8 1.7 2.0
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.1 -1.0 -0.9 0.5 -0.1 -1.8 0.2 -1.7 -1.0
Lung FEV1/FVC ratio 1.0 4.8 11.2 3.2 3.0 1.8 3.4 -0.3 0.8 0.5 1.8
Lung FVC 0.2 1.1 3.0 1.7 1.7 -0.1 0.7 0.7 -1.2 -0.6 0.6
Neuroticism 0.5 1.2 2.4 -1.2 -1.2 -1.1 0.8 -1.5 1.5 0.2 -0.2
Chronotype (morning person) 0.1 0.2 0.5 -0.5 -0.3 -0.1 -0.4 -0.7 -0.5 -0.3 -0.3
Hair Pigment 0.0 1.1 5.9 0.4 0.2 -0.4 -2.4 0.9 0.8 1.1 0.3
Tanning 0.1 1.4 3.7 1.2 1.4 1.4 1.0 0.2 -1.1 0.1 1.9
Hand grip strength (left) 0.7 1.8 4.4 1.7 1.5 -0.2 0.6 2.1 0.4 1.8 1.2
Number of treatments/medications taken 0.6 1.1 3.6 -0.3 -0.3 -0.3 1.1 1.9 1.6 0.6 0.6
Average weekly spirits intake 0.5 0.7 1.5 0.8 0.7 -0.2 -1.2 -1.0 1.1 0.2 0.7
Sensitivity / hurt feelings 0.3 0.6 4.0 -0.1 -0.0 0.4 2.0 -0.3 0.4 0.2 0.3
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.6 -0.5 -0.4 0.0 0.8 0.3 0.5 0.5 0.1
Hearing difficulty/problems: Yes 0.8 1.2 2.0 -1.2 -1.1 -0.8 0.1 0.5 1.4 -1.4 -1.3
Relative age of first facial hair 0.8 1.6 3.5 1.9 1.7 -1.1 0.5 0.8 -0.6 1.7 1.0
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 5.7 -0.8 -0.8 -0.7 -0.2 1.1 1.4 2.4 -0.6
Ever used hormone-replacement therapy (HRT) 0.4 0.5 2.3 -0.1 -0.2 0.2 0.3 0.4 1.5 0.9 0.5
Ever had hysterectomy (womb removed) 1.5 1.7 5.0 1.2 1.1 -0.8 -0.5 2.2 0.8 1.8 1.3
Systolic blood pressure, automated reading 0.5 1.5 4.8 0.4 0.2 -0.8 2.2 -1.4 1.2 -1.2 -1.2
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 1.3 -0.1 -0.2 1.1 0.4 0.3 -0.4 0.1 -0.3
Angina 0.5 0.7 1.8 -1.1 -1.3 0.1 0.9 0.1 0.8 0.4 -1.0
Medication for hormone replacement therapy 0.3 0.4 1.1 -1.0 -1.1 -0.1 -0.2 0.1 0.7 0.4 0.5
Vitamin and mineral supplements 2.8 3.8 8.5 -2.9 -2.6 -2.1 -0.5 -2.7 1.3 -0.8 -0.8
Supplements: Zinc 1.1 1.2 4.2 1.0 0.9 1.2 2.0 1.1 -0.7 -0.3 0.6
Medication: Co-codamol 0.8 0.9 1.9 1.3 1.4 0.6 0.4 1.4 -0.0 -0.7 -0.8
Medication: Metformin 0.8 1.2 3.3 -1.8 -1.6 -0.1 0.2 -0.9 1.1 -0.9 -0.6
Diabetes (father) 0.7 0.9 2.3 0.0 0.2 0.8 0.1 -1.5 -0.6 -1.4 -1.4
Diabetes (mother) 0.5 0.6 2.8 0.4 0.4 -0.3 0.2 -0.1 1.0 0.7 1.7
Severe depression (siblings) 0.5 0.6 1.8 -0.7 -0.6 -0.8 -1.0 0.1 0.2 1.3 0.5
Pack years adult smoking proportion 1.6 2.4 8.5 -2.9 -2.6 0.3 -0.0 -0.8 0.4 -1.6 -0.5
Impedance of leg (right) 2.2 10.7 24.7 5.0 4.8 2.0 3.2 -0.4 0.6 1.9 4.4
Leg fat-free mass (left) 1.5 8.2 18.6 -4.3 -4.0 -1.4 -2.5 0.1 -1.4 -2.7 -3.6
Trunk fat percentage 0.9 3.6 9.9 -3.1 -3.2 -1.2 -1.2 -0.3 0.2 -1.8 -1.8
Hand grip strength (right) 0.3 0.9 1.6 1.3 0.9 0.5 0.8 1.0 1.2 1.1 0.6
Townsend deprivation index at recruitment 0.3 0.4 1.0 -0.0 0.1 -1.0 -1.0 0.0 -1.0 -0.2 -0.7
Current tobacco smoking 0.8 1.3 2.7 -1.6 -1.4 1.2 -0.6 -0.0 0.9 0.4 1.6
Average weekly fortified wine intake 0.9 1.1 2.5 -1.0 -1.1 -1.6 -1.3 0.0 0.9 -0.0 -1.3
Maternal smoking around birth 1.4 2.0 5.2 1.0 1.0 0.7 0.2 2.0 -1.7 0.9 2.3
Fed-up feelings 0.8 1.5 3.1 -1.4 -1.4 -1.3 -0.2 -0.1 1.4 1.8 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 8.1 -0.4 -0.5 0.5 0.8 0.5 2.9 1.0 1.6
Relative age voice broke 2.1 3.2 10.4 3.2 2.9 1.3 1.5 -1.3 -0.0 -1.0 0.4
Taking other prescription medications 0.7 1.1 2.7 -1.6 -1.5 -0.9 0.3 0.2 1.6 0.5 0.3
Age when periods started (menarche) 0.7 1.7 5.6 0.4 0.4 1.2 -0.9 -2.1 0.8 0.8 2.4
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 4.3 -0.2 -0.3 -0.0 -1.0 1.0 2.1 0.6 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 4.9 1.8 1.7 -0.6 0.5 2.2 -1.4 1.1 1.0
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 3.6 -1.7 -1.9 -1.1 0.4 1.0 1.0 1.4 -0.0
Qualifications: CSEs or equivalent 0.4 0.5 2.4 -0.3 -0.1 0.9 -0.2 -0.8 -0.2 -1.6 -0.5
Serious illness, injury or assault to yourself 0.3 0.3 0.5 0.4 0.7 0.7 0.6 0.3 0.1 0.7 -0.6
High blood pressure 0.4 1.1 4.0 -0.2 -0.1 1.4 0.2 0.3 1.2 2.0 1.3
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.9 0.6 0.9 0.1 -0.3 1.1 -1.4 -0.2 -1.1
Multivitamins +/- minerals 3.5 4.4 9.1 3.0 2.7 2.2 1.2 2.8 -0.4 1.2 1.7
Stomach or abdominal pain in last month 1.2 1.6 7.2 -1.0 -0.9 -0.5 0.5 1.3 0.4 2.7 1.1
Supplements: Glucosamine 0.8 1.1 2.4 1.5 1.5 1.5 0.5 -0.0 -1.0 -0.4 0.5
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 9.9 -0.4 -0.4 -0.4 -3.1 2.6 0.3 1.5 -0.1
Medication: Atenolol 0.4 0.5 1.0 -0.8 -1.0 1.0 0.5 -0.9 -0.3 -0.7 -0.2
Medication: Levothyroxine sodium 1.3 2.2 9.3 -1.1 -1.0 -0.7 0.1 -0.8 -1.5 -1.6 -3.0
Sitting height 0.4 2.5 8.4 -0.6 -0.5 -0.9 -0.2 0.8 -2.9 -2.0 -2.4
Chronic bronchitis/emphysema (father) 1.9 2.2 6.6 1.7 2.0 2.6 -1.3 -0.6 -1.4 -0.7 0.5
High blood pressure (mother) 0.8 1.1 3.0 1.2 1.4 1.7 -1.1 -0.6 0.1 -0.8 -0.6
Body mass index (BMI) 1.0 4.2 9.0 -3.0 -2.9 -0.9 -2.0 -0.2 0.3 -2.3 -2.4
Impedance of leg (left) 2.2 10.5 26.5 5.1 4.8 1.9 3.2 -0.7 1.0 1.6 4.0
Leg predicted mass (left) 1.6 8.2 18.3 -4.3 -4.0 -1.6 -2.5 0.1 -1.4 -2.7 -3.7
Trunk fat mass 1.0 4.4 10.4 -3.2 -3.2 -1.2 -1.6 -0.5 -0.3 -2.4 -2.1
Waist circumference 0.9 3.3 8.3 -2.9 -2.8 -0.5 -1.8 -0.6 1.1 -2.1 -0.8
Number of incorrect matches in round 0.8 1.3 2.7 1.6 1.4 1.6 0.2 -0.3 -0.9 -1.4 0.6
Past tobacco smoking 1.0 1.7 3.9 -1.8 -1.7 -0.3 -0.3 1.2 -2.0 -0.4 -1.5
Alcohol usually taken with meals 0.3 0.5 2.1 0.5 0.4 0.5 -1.5 0.5 0.6 -0.5 -0.4
Nervous feelings 0.7 1.2 4.7 -0.6 -0.5 -1.1 -0.1 -0.6 2.2 1.1 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.7 -1.1 -0.9 0.5 0.2 0.8 0.5 1.3 0.6
Hearing difficulty/problems with background noise 0.5 0.7 2.4 -0.3 0.0 0.7 0.1 -0.7 1.5 -1.5 0.4
Hair/balding pattern: Pattern 2 1.1 1.3 6.3 0.4 0.4 -1.4 -0.8 0.3 -2.5 -1.2 0.0
Had menopause 1.0 1.3 3.3 1.8 1.5 0.9 0.1 -0.5 1.4 -0.2 1.2
Had other major operations 1.2 1.4 5.8 -0.1 -0.0 -1.8 -0.8 2.4 0.4 1.3 0.2
Forced vital capacity (FVC) 0.4 1.7 6.5 0.1 0.4 -0.3 -0.1 -0.5 -2.3 -2.5 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 2.7 1.7 1.6 -0.5 0.6 1.6 -0.8 1.2 1.5
Ever unenthusiastic/disinterested for a whole week 1.4 1.8 6.4 -1.4 -1.5 -0.5 0.3 -0.8 2.5 1.6 -0.5
Qualifications: None of the above 1.3 2.8 10.9 -1.6 -1.6 -0.7 -0.1 -1.8 3.3 0.5 1.8
Financial difficulties in last 2 years 0.9 1.2 4.9 -0.1 -0.2 -0.4 0.2 1.8 1.2 2.2 -0.1
Mouth/teeth dental problems 0.7 1.0 3.6 0.4 0.5 -0.1 1.0 -0.2 -1.2 -1.3 -1.9
Heart attack 3.1 3.9 8.3 -1.9 -2.0 -1.2 1.8 -2.5 1.4 -1.7 -2.9
Allergy 0.2 0.4 1.1 -0.4 -0.8 -0.3 0.9 -1.1 0.6 -0.6 0.2
Pain all over the body in last month 0.2 0.2 0.6 0.3 0.3 0.4 -0.5 0.8 0.6 0.1 0.3
Diabetes (self-reported) 0.5 0.8 1.6 -1.1 -1.0 -0.2 0.6 -1.3 0.9 -1.0 -0.7
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 5.1 -0.3 -0.4 -0.5 0.5 -0.3 -2.3 -1.2 -1.9
Medication: Ramipril 1.2 1.5 4.6 0.0 0.1 0.9 1.4 -0.9 2.1 -1.6 1.0
Medication: Simvastatin 1.9 2.8 4.8 -1.8 -1.9 -2.2 0.8 -1.1 1.8 -1.9 -1.6
Fluid intelligence score 0.2 0.5 2.6 -0.0 0.2 -0.5 0.0 1.6 -1.0 -0.2 -0.1
Illnesses of siblings 0.6 0.8 2.9 0.8 1.0 0.7 1.7 0.6 -0.7 0.4 0.6
Neuroticism score 0.6 1.2 2.2 -0.7 -0.7 -1.1 1.4 -1.3 1.2 1.5 0.5
Weight 0.9 4.7 9.3 -3.1 -2.9 -1.1 -2.1 -0.2 -0.6 -2.7 -2.5
Impedance of arm (right) 0.2 1.0 1.8 -1.2 -1.2 -1.1 1.3 0.2 -0.1 1.3 0.6
Arm fat percentage (right) 1.3 5.1 15.6 -3.9 -3.8 -1.4 -1.3 0.3 0.1 -1.7 -2.2
Trunk fat-free mass 0.5 2.8 5.9 -1.8 -1.6 -0.8 -1.6 0.2 -1.6 -2.4 -2.3
Hip circumference 1.0 4.4 9.4 -3.1 -3.0 -0.4 -2.0 0.3 -1.0 -2.8 -1.9
Time employed in main current job 0.6 0.7 2.8 0.4 0.4 -0.6 -0.7 -0.9 1.7 -0.1 -0.8
Alcohol intake versus 10 years previously 0.3 0.4 2.5 -0.1 0.1 1.6 0.5 0.6 -0.1 -0.2 0.2
Father’s age at death 0.5 0.7 1.3 -0.9 -1.1 -1.2 0.0 -0.6 0.4 -0.6 -1.1
Worrier / anxious feelings 1.1 2.1 4.4 -1.2 -1.4 -2.1 0.7 -1.2 1.8 1.8 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 3.9 -0.0 0.0 1.5 0.4 -1.4 2.0 0.3 1.2
Falls in the last year 0.3 0.4 1.5 -0.3 -0.3 -0.6 -1.2 0.3 0.1 0.6 -1.0
Hair/balding pattern: Pattern 3 0.8 1.3 6.4 0.2 0.1 0.6 2.5 0.7 1.4 0.8 -0.4
Number of live births 1.1 1.5 3.1 -1.7 -1.7 -1.2 -1.8 -0.4 0.1 -1.1 -0.4
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 6.3 0.4 0.6 0.1 0.5 -0.7 -2.5 -2.2 -0.7
Pulse rate 0.6 1.0 2.9 1.6 1.7 0.5 -0.3 -0.4 -0.6 -0.2 1.2
Happiness 1.2 1.4 4.3 -0.7 -0.9 -2.1 -0.8 0.9 1.4 0.7 -1.5
Noisy workplace 2.6 3.2 7.5 -2.2 -2.3 -2.7 1.4 0.2 2.0 1.3 -0.7
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.0 0.3 0.3 0.3 -1.0 -0.7 -1.0 -0.7 -1.4
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 2.4 -0.5 -0.8 1.5 1.0 0.5 0.6 1.2 -1.5
Mouth/teeth dental problems: Dentures 0.6 1.0 2.0 -1.3 -1.4 0.3 -0.3 -0.6 1.4 -0.5 1.4
Asthma 0.2 0.3 0.6 0.5 0.6 0.5 -0.8 -0.0 0.1 0.6 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.0 -0.0 -0.1 0.2 -1.4 0.5 1.0 0.1 0.8
Medication: Cholesterol lowering 1.5 2.3 8.4 -0.5 -0.5 -2.9 1.9 -0.8 1.7 -0.2 -1.6
Depression (self-reported) 1.4 1.7 3.8 -2.0 -1.9 -1.5 -0.1 -0.5 1.1 1.0 -1.1
Medication: Lansoprazole 1.5 1.7 6.5 -1.2 -1.1 -0.5 -1.0 -0.8 2.5 1.1 -1.2
Prospective memory result 1.2 1.5 7.2 -1.2 -1.4 0.2 0.1 -2.7 -1.1 -0.0 -0.4
Lung cancer (father) 2.1 2.5 8.5 -1.0 -1.2 -2.0 -0.7 1.9 1.0 2.9 -0.2
Illnesses of mother 1.2 1.4 5.6 -0.3 -0.4 0.0 1.4 1.5 -1.1 2.4 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 3.2 1.1 1.3 -0.3 -0.0 -0.8 -1.8 -1.8 -0.7
Pulse wave Arterial Stiffness index 0.6 0.8 2.6 -0.0 0.1 0.7 -0.4 -0.4 -1.3 -1.6 -0.9
Impedance of arm (left) 0.2 0.9 2.7 -1.1 -1.1 -0.8 1.2 -0.1 0.3 1.6 0.3
Arm fat mass (right) 1.4 5.8 15.6 -3.9 -3.8 -1.2 -1.9 -0.1 0.1 -2.3 -2.4
Trunk predicted mass 0.5 2.7 5.7 -1.8 -1.6 -0.7 -1.6 0.2 -1.5 -2.4 -2.2
Standing height 0.1 1.2 4.5 -0.8 -0.7 -1.0 -0.2 0.0 -2.1 -1.3 -0.9
Length of working week for main job 1.2 1.3 3.7 0.3 0.2 0.1 -1.4 1.6 1.4 1.9 0.3
Exposure to tobacco smoke at home 0.8 0.9 4.3 -0.1 -0.3 -0.2 2.1 -0.1 1.1 1.1 0.6
Breastfed as a baby 2.2 2.8 6.2 -2.2 -2.5 -1.7 -0.8 0.1 1.9 0.4 -2.0
Tense / ‘highly strung’ 0.5 0.8 2.0 0.3 0.3 -0.2 1.4 -1.0 1.2 -0.4 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 10.7 -0.1 -0.2 -0.1 -0.2 1.3 2.2 3.3 0.7
Hair/balding pattern: Pattern 4 0.4 0.9 1.7 1.1 1.1 1.3 -0.2 -0.3 1.1 -0.8 1.1
Birth weight of first child 0.5 1.0 2.5 -0.2 -0.4 -1.1 -1.6 -0.6 1.1 -0.3 -1.5
Peak expiratory flow (PEF) 0.9 2.2 6.1 2.1 2.2 0.7 -0.1 1.0 -2.5 -0.8 -0.1
Pulse wave reflection index 0.6 0.7 1.5 -0.9 -0.6 -0.2 -1.1 -0.6 0.1 -1.2 -1.1
Ever highly irritable/argumentative for 2 days 0.8 0.9 3.8 -0.5 -0.4 0.5 2.0 -1.0 1.1 -0.4 -0.7
Loud music exposure frequency 1.1 1.2 5.0 -0.1 0.1 0.3 0.3 1.2 1.5 2.2 0.9
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 5.2 -0.4 -0.2 0.6 0.5 0.6 -1.3 -0.3 -2.3
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.6 -1.3 -1.1 -0.1 -0.2 -0.7 0.2 -0.2 -0.4
Blood clot in the leg (DVT) 0.4 0.5 1.0 -1.0 -0.8 0.7 1.0 -0.5 0.5 0.3 -0.3
Medication: Paracetamol 1.0 1.7 2.8 -1.5 -1.7 -0.2 -1.4 1.2 1.3 1.2 -1.3
Headache pain in last month 0.7 1.3 4.9 -0.9 -1.1 -0.6 1.0 2.2 -0.4 1.4 -0.3
Medication for cholesterol, blood pressure or diabetes 0.8 1.2 4.7 0.2 0.2 1.6 -2.2 0.4 -1.1 -0.4 1.0
Glaucoma (self-reported) 2.2 2.6 10.7 -0.5 -0.1 1.8 -2.1 -0.8 3.3 -0.5 1.0
Gout (self-reported) 0.6 0.9 3.1 -0.4 -0.1 -0.2 -0.2 1.3 -0.8 1.8 1.1
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 4.5 -1.1 -1.0 -0.0 -0.8 -0.3 -1.5 -0.8 -2.1
Medication: Amlodipine 0.8 1.1 3.5 -0.9 -0.5 1.4 -0.3 -0.9 -0.9 -0.6 1.9
Medication: Ventolin 100micrograms inhaler 0.8 1.1 2.9 1.4 1.4 1.7 0.4 0.1 -0.4 -0.5 1.0
Birth weight 0.6 1.4 3.3 -1.3 -1.0 -1.1 -0.8 -1.2 1.8 -1.0 -0.9
Chronic bronchitis/emphysema (mother) 2.1 2.5 8.0 -2.8 -2.7 -0.5 -1.5 -0.5 1.2 -0.6 0.1
High blood pressure (siblings) 0.7 1.0 2.5 -1.1 -1.3 0.1 -1.6 -0.9 1.1 -0.2 -0.9
Forced vital capacity (FVC), Best measure 0.3 1.2 4.1 0.7 0.8 -0.4 -0.6 -0.6 -1.7 -2.0 -0.8
Body fat percentage 0.6 2.2 6.2 -2.5 -2.5 -0.8 -0.8 -0.1 0.3 -1.6 -1.3
Leg fat percentage (right) 0.2 0.7 4.4 -0.5 -0.5 0.4 -0.1 -0.8 0.4 -2.1 0.0
Arm fat-free mass (right) 0.4 2.2 5.5 -1.3 -1.3 -0.2 -1.9 -0.4 -1.0 -2.3 -2.0
Exposure to tobacco smoke outside home 1.0 1.3 3.9 0.8 0.8 2.0 -0.1 -0.7 1.0 0.7 1.9
Comparative body size at age 10 0.3 0.8 2.6 0.3 0.4 1.6 -1.5 0.4 -0.9 -0.9 0.0
Number of full brothers 1.2 1.5 4.2 -1.5 -1.5 -2.1 -0.6 -0.8 0.2 -0.3 -1.3
Worry too long after embarrassment 0.8 1.4 2.9 -0.9 -1.0 -1.4 0.3 -1.2 1.1 -1.1 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.0 8.9 -0.1 -0.3 -1.7 -0.5 1.7 0.7 3.0 0.7
Wheeze or whistling in the chest in last year 0.2 0.3 1.1 -0.5 -0.4 0.5 -0.3 0.4 0.5 0.6 1.1
Number of children fathered 0.8 0.9 2.7 -1.0 -1.0 -1.0 -1.0 0.4 -0.1 0.2 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 4.5 0.1 0.1 1.6 -0.6 -0.2 -2.1 -0.2 0.6
Age at first live birth 0.4 0.8 1.5 1.2 1.2 0.5 1.1 0.8 -0.3 0.3 -1.1
Pulse wave peak to peak time 0.7 0.8 2.8 -0.1 -0.2 -0.8 0.3 0.5 1.4 1.7 0.9
Health satisfaction 1.3 1.6 7.1 -0.8 -1.0 -0.6 -1.1 -1.5 2.7 0.1 -0.8
Shortness of breath walking on level ground 0.8 0.9 2.4 -1.6 -1.4 -0.0 0.9 0.8 -0.1 0.2 -1.3
Qualifications: College or University degree 0.5 1.5 3.4 0.6 0.6 -1.6 -1.9 1.5 -0.8 1.3 -0.6
Eye problems/disorders: None of the above 1.5 1.7 6.8 1.1 1.0 -0.5 1.7 0.9 -2.6 -0.5 0.5
Mouth/teeth dental problems: Loose teeth 1.6 1.9 4.9 -2.2 -2.2 -0.6 -0.4 -0.5 1.9 0.3 -0.9
Emphysema/chronic bronchitis 0.8 0.9 2.4 0.1 0.3 0.4 -0.9 -0.5 1.6 1.2 1.3
Medication for pain relief, constipation, heartburn 0.8 1.4 2.6 1.2 1.6 0.6 0.6 -1.5 -1.3 -0.9 1.5
Neck or shoulder pain in last month 0.4 0.6 2.7 0.6 0.6 -0.7 0.7 0.3 -1.7 0.2 -0.6
Medication: Blood pressure 0.3 0.6 3.5 0.2 0.1 0.1 1.9 -0.6 0.5 0.7 -0.2
Angina (self-reported) 0.6 0.8 2.3 -1.3 -1.5 -0.2 0.9 -0.3 0.8 0.1 -1.0
Migraine (self-reported) 0.7 0.9 3.8 -0.5 -0.5 -0.2 -0.6 1.0 -1.2 -0.3 -1.9
Medication: Ibuprofen 0.6 0.7 2.7 0.3 0.3 -0.0 -1.7 0.2 0.9 -0.4 1.2
Medication: Allopurinol 1.0 1.3 3.7 -0.6 -0.4 -0.6 -1.0 1.9 0.4 1.8 1.3
Medication: Omeprazole 0.9 1.0 2.3 -0.7 -1.1 -1.4 -1.0 0.6 1.5 0.7 -0.7
Medication: Seretide 50 evohaler 1.0 1.1 6.6 0.1 -0.0 0.3 0.1 0.9 1.1 2.6 -0.5
Mean time to correctly identify matches 0.9 1.7 4.8 -1.0 -0.8 -1.0 -0.6 -2.2 1.1 -2.1 -0.5
Heart disease (mother) 0.7 0.9 3.3 -0.2 -0.5 -1.8 -0.2 -0.4 -0.1 -1.0 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 3.5 0.3 0.4 -0.3 -0.2 1.9 -0.3 -0.2 -0.4
Whole body fat mass 0.9 3.6 9.0 -3.0 -2.9 -1.0 -1.3 -0.2 -0.1 -2.2 -1.9
Leg fat mass (right) 0.5 2.0 6.1 -1.9 -1.8 -0.2 -1.3 -0.6 -0.0 -2.5 -1.0
Arm predicted mass (right) 0.4 2.0 4.4 -1.3 -1.2 -0.1 -1.7 -0.1 -1.1 -2.1 -2.0
Pulse rate, automated reading 0.7 2.1 6.2 2.5 2.3 0.5 -0.4 1.1 -0.5 0.9 1.7
Alcohol intake frequency. 1.5 3.5 10.3 -3.2 -3.0 -0.4 -0.6 -0.1 -0.9 -2.0 -1.9
Comparative height size at age 10 0.4 2.4 6.1 -0.6 -0.7 0.5 2.3 0.8 -2.5 -2.4 -0.6
Number of full sisters 2.6 3.1 8.3 -2.9 -2.6 -2.0 -0.6 -1.3 1.9 -0.5 -0.1
Suffer from ‘nerves’ 0.5 0.7 2.6 0.0 -0.0 -0.7 1.0 -1.1 1.6 0.6 -0.3
Overall health rating 0.6 1.3 4.3 -1.5 -1.5 -0.2 0.5 -1.2 2.1 -0.3 -0.3
Chest pain or discomfort 2.9 4.2 11.5 -2.5 -2.6 -0.6 1.1 2.2 1.2 3.4 1.0
Had major operations 1.3 1.6 3.2 1.7 1.8 -0.0 1.4 1.0 -0.2 1.2 1.4
Age at last live birth 0.7 1.0 1.8 1.4 1.2 -0.0 0.8 1.1 -1.1 -0.2 -1.3
Family relationship satisfaction 0.5 0.6 1.7 -0.2 -0.3 -0.7 0.5 1.3 -1.0 1.0 -0.6
Leg pain on walking 1.8 2.3 6.1 -2.2 -2.5 -1.2 0.4 -0.8 2.1 0.8 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.6 -0.0 0.1 0.8 0.7 -0.2 -0.8 -0.1 0.1
Commuting to job workplace: Car/motor vehicle 1.0 1.2 3.4 0.3 0.3 -0.3 1.7 -1.4 1.0 -1.8 0.3
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 9.2 -0.2 -0.0 0.2 -1.0 -0.8 -3.0 -2.1 1.3
Medication: Aspirin 0.7 0.9 2.0 -1.2 -1.4 -0.2 0.8 -0.2 1.2 -0.7 -0.9
Supplements: Vitamin C 1.1 1.3 3.8 1.9 1.7 1.2 -0.4 1.0 -0.8 -0.2 -0.7
Knee pain experienced in last month 0.8 1.3 3.6 0.4 0.4 0.7 0.9 -1.4 1.6 -0.7 1.9
Hypertension (Self-reported) 0.5 1.4 4.4 0.2 0.1 1.8 -0.5 0.1 1.1 2.1 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 4.1 -1.1 -1.4 -1.2 0.2 -0.1 2.0 0.6 -1.5
Illnesses of father: Heart disease 1.0 1.4 3.3 -1.5 -1.6 -1.1 1.8 -0.4 1.3 0.1 -0.1
Illnesses of siblings: Diabetes 1.5 1.9 9.7 -0.8 -0.8 0.1 -3.1 0.4 0.6 1.6 1.0
Smoking status: Previous 1.0 1.5 3.6 1.9 1.8 -0.2 0.7 -0.9 1.7 0.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.4 -0.6 -0.5 -0.5 -0.4 -0.1 0.1 -0.4 -0.5
Whole body fat-free mass 0.8 4.7 8.7 -2.9 -2.7 -1.2 -1.9 0.1 -1.4 -2.6 -3.0
Leg fat-free mass (right) 1.7 9.0 19.6 -4.4 -4.2 -1.7 -2.4 0.1 -1.3 -2.7 -4.1
Arm fat percentage (left) 1.2 5.0 15.2 -3.9 -3.8 -1.0 -1.3 0.2 0.0 -1.6 -2.3
Average weekly red wine intake 1.6 2.4 7.9 2.8 2.8 0.2 -1.3 0.5 -0.5 0.7 0.8
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.6 0.7 0.6 -1.1 1.0 1.6 0.8 1.2 0.5
Mood swings 0.8 1.5 3.2 -1.0 -1.1 -1.3 1.8 -0.7 1.6 1.3 0.3
Loneliness, isolation 0.6 0.8 3.1 -0.5 -0.5 -0.6 -0.1 0.8 0.7 1.8 1.0
Long-standing illness, disability or infirmity 2.2 3.4 12.7 -1.9 -1.8 -0.6 0.0 0.2 3.6 2.2 1.6
Ever had bowel cancer screening 0.8 1.0 4.2 -0.1 -0.2 0.2 -1.8 0.1 0.3 0.4 -2.0
Diabetes diagnosed by doctor 0.4 0.6 1.3 -1.0 -0.9 0.5 0.0 -0.8 0.5 -1.1 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.1 4.6 0.0 -0.1 -1.6 -2.2 1.9 1.2 1.9 -1.0
Friendships satisfaction 0.6 0.8 2.0 1.4 1.2 0.5 0.5 1.4 -0.2 0.5 -0.5
Qualifications: nursing, teaching 1.1 1.6 7.7 -0.1 0.2 -2.8 -0.4 1.1 -1.7 0.5 -0.9
Commuting to job workplace: Walk 0.6 0.6 1.7 -0.8 -0.7 -0.6 -0.0 0.1 -0.9 1.0 1.3
Eye problems/disorders: Cataract 0.7 0.8 2.1 0.3 0.2 0.0 -1.3 -1.3 0.6 0.1 -1.5
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.7 1.1 1.0 0.1 -0.2 2.2 0.5 1.8 1.6
Medication for cholesterol 0.3 0.5 1.0 1.0 0.9 -0.7 0.3 -0.6 0.5 0.9 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 2.6 1.5 1.6 0.4 -0.2 1.4 -1.5 1.3 -1.1
Back pain experienced in last month 0.8 1.1 3.2 1.2 1.0 0.9 0.8 1.3 -0.4 0.5 1.8
Mineral and other dietary supplements 1.1 1.5 4.0 -2.0 -1.7 -1.1 -0.7 -1.7 0.0 -0.7 -0.2
Breast cancer (self-reported) 0.2 0.2 0.7 -0.5 -0.4 -0.4 -0.2 0.8 -0.5 -0.6 0.2
Asthma (self-reported) 0.1 0.3 0.6 0.5 0.6 0.4 -0.7 -0.0 0.2 0.7 0.7
Osteoporosis (self-reported) 1.2 1.5 4.8 -0.3 -0.3 -0.1 -1.6 -1.0 2.2 1.8 0.4
Osteoarthritis (self-reported) 0.4 0.5 2.8 -0.5 -0.6 -0.4 -1.7 0.3 0.6 -0.4 -0.2
Medication: Aspirin 0.6 0.8 2.1 -1.1 -1.4 -0.1 0.5 -0.5 1.4 -0.7 -0.7
Medication: Gliclazide 0.3 0.3 0.9 -0.5 -0.4 -0.8 -0.4 0.1 0.9 -0.1 0.7
Illnesses of father: None of the above (group 1) 0.5 0.6 1.8 -1.1 -1.3 -0.3 -0.6 0.7 -0.1 0.9 0.3
Smoking status: Current 0.9 1.5 2.7 -1.6 -1.4 1.5 -0.9 -0.4 1.1 0.5 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.5 0.7 0.7 0.1 0.3 -0.7 -0.3 -0.6 -0.4
Whole body water mass 0.9 5.0 9.5 -3.0 -2.8 -1.2 -2.0 0.1 -1.3 -2.6 -3.1
Leg predicted mass (right) 1.7 9.2 20.0 -4.5 -4.2 -1.8 -2.5 0.2 -1.3 -2.7 -4.1
Arm fat mass (left) 1.3 5.4 15.0 -3.9 -3.7 -1.0 -1.8 -0.0 -0.1 -2.2 -2.3
Number of self-reported non-cancer illnesses 1.0 1.8 5.5 -1.1 -1.1 -0.7 0.2 1.3 2.1 2.4 -0.0
Average weekly champagne plus white wine intake 0.6 0.9 2.4 -0.6 -0.6 -1.6 -0.9 1.3 0.7 0.8 -0.4
Miserableness 0.5 0.8 3.9 -0.1 -0.0 -0.7 0.5 0.6 0.9 2.0 -0.7
Guilty feelings 0.7 1.1 5.6 -0.5 -0.6 -0.3 2.4 -0.0 0.5 1.5 -0.2
Wears glasses or contact lenses 1.5 1.7 5.1 -0.9 -0.8 -0.6 -1.7 0.8 1.9 2.3 -0.3
Ever taken oral contraceptive pill 1.0 1.2 6.5 0.1 0.0 -0.4 2.5 0.9 0.1 1.2 -0.6
Hearing aid user 0.7 0.8 1.6 0.4 0.4 0.0 1.1 -1.2 1.1 -1.3 0.7
Mother’s age at death 0.7 0.9 2.1 1.1 1.1 0.1 0.8 1.3 1.5 0.5 0.5
Financial situation satisfaction 0.7 0.9 2.8 0.4 0.3 0.8 0.5 1.7 -0.1 1.2 1.3
Tinnitus: Yes, now most or all of the time 1.7 2.0 8.3 -1.5 -1.3 -1.6 0.5 -1.0 2.9 -0.2 0.5
Commuting to job workplace: Public transport 1.5 1.8 4.8 -1.1 -1.4 -0.3 -1.4 1.6 0.9 2.2 -0.9
Eye problems/disorders: Glaucoma 2.8 3.3 12.0 -0.2 0.3 2.6 -1.8 -0.9 3.5 -0.9 1.6
Medication: Blood pressure 0.7 1.3 4.4 -0.1 0.1 2.1 -0.4 1.0 -0.5 0.8 1.9
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.0 0.0 0.5 -0.1 0.4 0.3 0.5 0.2
Supplements: Fish oil (including cod liver oil) 1.2 1.6 5.3 2.3 2.0 0.9 0.9 1.0 0.7 0.2 0.0
High cholesterol (Self-reported) 0.6 1.0 3.5 -0.1 -0.3 -1.9 1.0 -0.6 0.7 -1.3 -1.1
Medication: Bendroflumethiazide 0.6 0.9 2.4 0.3 0.2 1.6 -0.3 0.7 -1.0 0.8 1.5
Medication: Paracetamol 0.6 0.9 2.1 -1.4 -1.5 -0.1 -0.6 0.4 1.2 0.5 -1.1
Medication: Lisinopril 1.4 1.8 4.3 -0.8 -0.7 -1.4 1.4 1.8 -1.3 2.1 0.2
Medication: Atorvastatin 0.8 1.0 3.0 0.4 0.4 -0.7 1.2 -1.1 -0.6 -1.7 -0.9
Illnesses of father: High blood pressure 1.2 1.5 4.2 0.1 0.3 1.8 -2.0 -1.9 0.0 -0.9 0.5
Alcohol drinker status: Never 1.7 2.0 4.2 1.0 1.1 2.1 1.4 -0.5 -1.8 -2.0 0.0
Ever smoked 0.2 0.3 1.2 0.5 0.5 0.1 0.2 -0.5 0.7 0.1 1.1
Basal metabolic rate 0.9 5.0 9.4 -3.1 -2.9 -1.1 -2.0 0.1 -1.2 -2.6 -2.9
Leg fat percentage (left) 0.3 1.0 5.4 -0.6 -0.6 0.2 -0.0 -1.0 0.7 -2.3 -0.3
Arm fat-free mass (left) 0.5 2.3 5.6 -1.6 -1.6 -0.4 -1.9 0.0 -0.8 -2.4 -1.9
Number of operations (self-reported) 2.2 3.2 11.1 1.4 1.4 0.1 1.0 3.3 -0.4 2.8 1.2
Average weekly beer plus cider intake 0.4 0.6 2.7 0.4 0.4 0.5 1.7 -0.7 -0.5 0.6 0.8
Irritability 0.7 1.3 4.7 0.2 0.3 0.1 1.8 -1.3 0.3 0.4 2.2
Risk taking 0.4 0.7 2.0 -0.2 -0.4 0.2 1.0 0.1 -0.0 1.4 1.4
Ever had prostate specific antigen (PSA) test 0.4 0.5 2.3 -0.4 -0.4 -0.2 0.5 -0.8 1.5 -0.4 0.2
Fractured/broken bones in last 5 years 0.7 0.9 3.3 -1.8 -1.7 0.1 0.9 0.1 -0.6 0.1 -0.2
Age started oral contraceptive pill 1.1 1.4 3.5 1.9 1.5 -0.4 1.7 0.5 -1.2 -0.1 1.0
Diastolic blood pressure, automated reading 0.2 0.7 1.5 0.9 0.7 -1.2 0.4 -1.0 1.2 0.1 -0.5
Ever depressed for a whole week 1.7 2.2 5.2 -2.0 -1.9 -1.5 1.0 0.1 1.1 0.2 -2.3
Unable to work because of sickness or disability 1.7 2.2 5.3 -2.3 -2.3 -0.5 -0.9 -0.8 1.3 1.3 -1.3
Commuting to job workplace: Cycle 0.6 0.8 1.7 1.0 1.3 1.0 -0.1 -0.2 -0.3 -1.1 1.1
Myopia 0.3 0.4 0.8 0.8 0.9 0.7 -0.6 0.5 0.4 -0.1 -0.8
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.9 0.4 0.4 -1.0 -0.8 0.0 -0.9 -1.4 -0.1
Cholesterol lowering medication 1.1 1.7 9.1 -0.6 -0.7 0.1 0.1 -0.6 -1.5 -3.0 -0.9
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.9 -0.4 -0.9 -1.3 -1.7 0.2 1.5 1.2 -0.3
Pain experienced in last month 1.2 2.0 4.1 -2.0 -1.9 -1.5 -1.0 -0.8 1.2 -0.4 -1.7
Supplements: Calcium 0.6 0.7 2.6 -0.7 -0.7 -0.5 -0.1 0.8 -0.2 1.6 0.9
Basal cell carcinoma (self-reported) 1.2 1.4 4.5 0.6 0.6 -1.7 2.1 1.3 -1.1 0.1 0.6
Heart attack/myocardial infarction (self-reported) 3.1 4.0 8.5 -2.0 -2.0 -1.1 1.8 -2.4 1.4 -1.8 -2.9
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.0 -0.5 -0.3 0.8 1.0 -0.8 0.3 0.1 -0.1
Heart disease (siblings) 0.5 0.6 1.4 -0.9 -1.1 -1.2 0.4 0.2 0.8 -0.7 0.2
Alcohol drinker status: Previous 1.3 1.5 4.7 -2.2 -2.0 0.5 -1.4 -0.1 -0.2 -0.0 -1.1
Pack years of smoking 1.5 2.1 7.0 -2.6 -2.4 0.2 -0.0 -0.9 0.4 -1.7 -0.4
Impedance of whole body 0.5 2.7 5.8 1.9 1.8 0.4 2.4 -0.2 0.3 1.9 2.3
Leg fat mass (left) 0.5 2.1 6.2 -2.0 -1.9 -0.2 -1.3 -0.6 0.1 -2.5 -1.0
Arm predicted mass (left) 0.4 2.1 5.8 -1.6 -1.5 -0.5 -1.3 0.1 -0.8 -2.4 -1.9