TWAS hub - FAM113A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0315	0.0118	0.0029	0.001	0.008	0.004	0.009	0.001	0.1100	0.00076	0.011	0.00062	0.110
2	TCGA	Esophageal Carcinoma	0.1270	0.0630	0.0050	0.051	0.030	-0.006	NA	0.033	0.0098	0.03800	0.560	NA	0.032

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Ever used hormone-replacement therapy (HRT)	5.7	7.3	12.9	-1.3	3.6
Pulse wave reflection index	5.0	6.1	6.3	2.4	-2.5
Qualifications: College or University degree	4.2	13.2	19.4	4.4	-2.7
Medication for hormone replacement therapy	3.9	4.4	7.7	-1.0	2.8
Family relationship satisfaction	3.9	4.8	7.1	1.6	-2.7
Exposure to tobacco smoke at home	3.8	4.3	8.6	-2.9	0.1
Eye problems/disorders: Diabetes related eye disease	3.6	4.0	6.8	-2.6	1.1
Bilateral oophorectomy (both ovaries removed)	3.6	4.2	8.2	-0.4	2.9
Maternal smoking around birth	3.2	4.7	5.9	-1.9	2.4
Medication for pain relief, constipation, heartburn	3.1	5.2	6.9	2.6	-1.9
Heart disease (siblings)	3.1	3.8	6.5	-1.1	2.5
Impedance of leg (right)	3.0	14.4	28.5	0.6	-5.3
Impedance of leg (left)	3.0	14.5	28.8	0.5	-5.4
Medication: Paracetamol	3.0	4.9	5.9	-2.4	2.0
Wears glasses or contact lenses	2.9	3.3	6.7	0.1	-2.6
Mean Putamen Volume	2.8	3.2	5.9	0.7	2.4
Depression (self-reported)	2.8	3.3	4.3	-2.1	1.5
Overall health rating	2.8	6.1	11.2	-3.3	1.0
Age at First Birth	2.7	3.9	4.6	2.1	-1.8
Lupus	2.7	4.0	4.2	2.0	-2.0
Average weekly fortified wine intake	2.7	3.1	3.7	-1.9	1.6
Pack years adult smoking proportion	2.6	4.0	7.4	-0.7	2.7
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	4.6	-2.1	1.3
Medication: Paracetamol	2.6	4.0	6.9	-2.6	1.1
Ever had prostate specific antigen (PSA) test	2.6	3.0	5.2	2.3	-0.9
Medication: Levothyroxine sodium	2.5	4.3	6.2	1.6	-2.5
Alcohol intake versus 10 years previously	2.5	3.8	4.5	-1.8	2.1
Ever smoked	2.5	4.4	5.8	-1.7	2.4
Impedance of whole body	2.5	12.7	22.1	1.8	-4.7
Illnesses of mother	2.4	3.0	5.8	-0.5	-2.4
Pack years of smoking	2.4	3.5	6.7	-0.6	2.6
Bipolar Disorder or Schizophrenia	2.3	5.7	8.9	3.0	-1.6
HDL Cholesterol	2.3	3.9	5.5	2.3	-1.5
Schizophrenia (2014)	2.3	5.0	6.0	2.5	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	8.2	-1.4	2.9
Smoking Status	2.2	5.2	9.7	-0.8	3.1
Pulse wave Arterial Stiffness index	2.2	2.5	4.9	0.4	-2.2
Systolic Blood Pressure	2.1	10.4	18.3	4.3	-1.6
Fasting Glucose	2.0	2.3	4.6	0.1	-2.2
Impedance of arm (right)	2.0	9.5	14.1	2.2	-3.8
Qualifications: A levels/AS levels or equivalent	2.0	4.4	4.8	2.0	-2.2
Knee pain experienced in last month	2.0	3.0	3.8	-1.5	1.9
Schizophrenia (2018)	1.9	4.0	5.3	2.3	-1.7
BMI	1.9	11.3	19.4	-1.8	4.4
Average weekly spirits intake	1.9	2.4	2.6	-1.5	1.6
Pain all over the body in last month	1.9	2.0	3.1	-1.8	0.9
Number of full brothers	1.9	2.4	4.3	0.7	2.1
Pulse wave peak to peak time	1.9	2.3	4.5	-0.2	2.1
Eye problems/disorders: None of the above	1.9	2.2	3.1	1.1	1.8
Age started oral contraceptive pill	1.9	2.4	3.8	2.0	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	3.4	-1.9	1.1
Systolic blood pressure, automated reading	1.8	5.2	6.4	2.5	-2.0
Medication: Lansoprazole	1.8	2.0	2.8	-1.7	1.1
Impedance of arm (left)	1.8	8.2	11.8	2.2	-3.4
Peak expiratory flow (PEF)	1.8	4.1	4.8	2.2	-1.9
Eye problems/disorders: Glaucoma	1.8	2.1	4.2	0.1	-2.0
Coronary Artery Disease (CAD)	1.7	2.0	4.0	-2.0	0.2
HbA1C	1.7	1.8	2.5	-1.6	1.1
Leg fat-free mass (left)	1.6	8.6	17.0	0.4	4.1
Leg predicted mass (left)	1.6	8.7	17.2	0.3	4.2
Age at first live birth	1.6	2.9	4.0	2.0	-1.3
Medication: Omeprazole	1.6	1.9	3.6	-1.9	0.5
Leg fat-free mass (right)	1.6	8.7	17.1	0.5	4.1
Leg predicted mass (right)	1.6	8.5	16.7	0.6	4.1
Commuting to job workplace: Public transport	1.6	1.9	3.5	0.5	-1.9
Diastolic blood pressure, automated reading	1.6	5.1	10.0	3.2	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.4	-2.1	0.7
Prospective memory result	1.5	1.8	1.8	-1.4	1.4
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	4.0	1.4	-2.0
Schizophrenia vs Biploar Disorder	1.4	1.8	3.6	0.1	-1.9
Ovarian Cancer	1.4	1.9	2.6	-1.6	1.1
Medication: Co-codamol	1.4	1.7	1.7	-1.3	1.3
Relative age voice broke	1.4	2.1	4.2	2.1	0.0
Exposure to tobacco smoke outside home	1.4	1.9	2.6	-1.6	-1.0
Father’s age at death	1.3	1.8	2.3	1.2	-1.5
Pulse rate	1.3	2.2	4.1	0.4	2.0
Happiness	1.3	1.5	2.9	-0.4	-1.7
Medication: Cholesterol lowering	1.3	2.1	4.1	0.2	2.0
Blood clot in the leg (DVT)	1.3	1.7	2.6	-0.9	1.6
Health satisfaction	1.3	1.7	3.1	-0.6	1.8
Mouth/teeth dental problems: Loose teeth	1.3	1.6	2.3	-0.9	1.5
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.4	0.8	1.5
Medication: Gliclazide	1.3	1.4	2.9	-0.0	1.7
Miserableness	1.3	2.3	2.6	-1.4	-1.6
Bipolar Disorder (2018)	1.2	1.9	3.6	1.9	-0.4
Alzheimer’s Disease (in mother)	1.2	1.4	2.4	-0.6	1.6
Chronotype (morning person)	1.2	2.9	3.0	1.6	-1.7
Current tobacco smoking	1.2	1.9	3.2	-0.8	1.8
Serious illness, injury or assault to yourself	1.2	1.4	2.8	0.3	1.7
Chronic bronchitis/emphysema (mother)	1.2	1.5	2.6	-0.6	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.4	1.5	-0.7
Alcohol intake frequency.	1.2	2.7	4.2	-1.1	2.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.9	-0.1	-1.7
Medication: Aspirin	1.2	1.6	2.3	-1.5	0.9
Whole body fat-free mass	1.2	6.7	13.4	0.3	3.7
Loneliness, isolation	1.2	1.7	2.7	-1.6	0.8
Whole body water mass	1.2	7.0	14.0	0.2	3.7
Financial situation satisfaction	1.2	1.5	1.6	-1.2	1.3
Illnesses of father: High blood pressure	1.2	1.5	2.2	1.5	-0.9
Type 2 Diabetes (T2D) (2018)	1.1	2.2	2.6	-1.3	1.6
Fluid intelligence score	1.1	2.2	2.7	1.6	-1.3
Breastfed as a baby	1.1	1.4	2.8	-0.1	1.7
Wheeze or whistling in the chest in last year	1.1	2.0	2.7	-1.6	1.1
Leg pain on walking	1.1	1.4	2.6	-1.6	0.5
Average weekly red wine intake	1.1	1.6	3.1	-1.8	0.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.3	-0.3	1.8
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.5	0.6	-1.6
Basal metabolic rate	1.1	6.1	12.1	0.1	3.5
Neuroticism (2016)	1.0	1.4	2.6	-1.6	0.5
Blood White Count	1.0	7.6	14.9	-0.6	-3.9
Number of treatments/medications taken	1.0	1.8	3.3	-0.4	1.8
Relative age of first facial hair	1.0	2.0	3.1	1.8	-1.0
Townsend deprivation index at recruitment	1.0	1.4	2.9	-1.7	-0.1
Body mass index (BMI)	1.0	4.5	7.5	-1.2	2.7
Past tobacco smoking	1.0	1.8	2.0	1.4	-1.2
Arm fat mass (right)	1.0	4.0	7.9	-0.2	2.8
Gout (self-reported)	1.0	1.3	1.7	-1.0	1.3
Arm fat-free mass (right)	1.0	5.3	10.6	-0.2	3.3
Arm predicted mass (right)	1.0	5.0	10.0	-0.2	3.2
Hypertension (Self-reported)	1.0	2.8	3.7	1.4	1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.9	1.7	-1.1
Eye problems/disorders: Cataract	1.0	1.2	2.0	0.5	-1.4
Breast cancer (self-reported)	1.0	1.2	2.3	-0.1	1.5
Osteoarthritis (self-reported)	1.0	1.2	2.4	-0.2	-1.6
Risk taking	1.0	1.4	2.8	-0.1	1.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.1	-0.6	1.5
Arm predicted mass (left)	1.0	5.0	9.9	-0.3	3.1
Alzheimer’s Disease (including proxy)	0.9	1.4	1.7	-1.0	1.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	1.4	-1.2	-0.9
Sitting height	0.9	6.2	9.6	3.1	-1.7
Chronic bronchitis/emphysema (father)	0.9	1.0	2.0	-1.4	0.0
Medication: Ramipril	0.9	1.2	2.1	-0.5	1.5
Medication: Allopurinol	0.9	1.2	1.6	-0.9	1.2
Medication: Seretide 50 evohaler	0.9	1.0	1.5	1.2	-0.7
Number of full sisters	0.9	1.1	1.3	-1.0	1.1
Chest pain or discomfort	0.9	1.3	1.7	-1.3	1.0
Smoking status: Previous	0.9	1.4	2.1	-1.5	0.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.1	1.0	-1.1
Medication: Bendroflumethiazide	0.9	1.3	1.4	1.1	1.2
Arm fat-free mass (left)	0.9	4.7	9.2	-0.3	3.0
Alcohol drinker status: Previous	0.9	1.1	1.6	-0.8	1.2
Triglycerides	0.8	1.4	1.8	-1.3	1.0
Blood Eosinophil Count	0.8	6.2	11.1	1.2	-3.3
Neuroticism	0.8	1.9	3.5	-0.5	-1.9
Diabetes (father)	0.8	1.0	1.5	-0.7	1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.5	-1.2	-0.5
Waist circumference	0.8	3.1	5.3	-0.9	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.2	-0.6	1.8
Trunk fat-free mass	0.8	4.5	8.9	0.3	3.0
Trunk predicted mass	0.8	4.4	8.8	0.3	3.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	1.8	-0.9	-1.3
Shortness of breath walking on level ground	0.8	0.9	1.8	-1.4	0.1
Age at last live birth	0.8	1.2	2.2	1.5	-0.4
Mood swings	0.8	1.4	2.7	-1.6	0.4
Back pain experienced in last month	0.8	1.2	2.3	0.4	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.1	1.8	-0.4
Arm fat mass (left)	0.8	3.4	6.6	-0.4	2.6
Hearing aid user	0.8	0.9	1.8	1.3	-0.2
Medication: Blood pressure	0.8	1.6	3.2	0.2	1.8
Reaction Time	0.7	1.4	1.5	-1.1	1.2
Verbal and Numeric Reasoning (VNR)	0.7	1.8	2.9	1.7	-0.8
Primary Biliary Cirrhosis	0.7	0.9	1.4	-0.7	1.2
Cardiovascular Disease	0.7	2.5	4.6	0.6	2.1
Sensitivity / hurt feelings	0.7	1.1	2.1	-1.5	-0.3
Diabetes (mother)	0.7	0.8	1.3	0.7	1.1
Severe depression (siblings)	0.7	0.8	1.5	1.2	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.2	-0.2	-1.5
Allergy	0.7	1.6	2.5	1.6	-0.9
Illnesses of siblings	0.7	1.0	1.0	-1.0	-1.0
Noisy workplace	0.7	0.8	0.9	-1.0	0.8
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.3	-0.5	1.1
Glaucoma (self-reported)	0.7	0.8	1.3	-0.5	-1.1
Neck or shoulder pain in last month	0.7	1.0	2.0	-1.4	0.3
Migraine (self-reported)	0.7	0.8	0.9	0.9	1.0
Medication: Ibuprofen	0.7	0.8	1.6	0.0	-1.3
Commuting to job workplace: Walk	0.7	0.8	1.4	-1.2	0.4
Medication for cholesterol	0.7	1.0	1.4	0.8	-1.2
Smoking status: Current	0.7	1.0	2.1	-0.1	1.4
Depressed Affect (Nagel 2018)	0.6	1.3	2.5	-1.6	-0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	0.8	0.9	-0.7
Hypothyroidism (self reported)	0.6	1.4	1.5	1.2	-1.2
Age when periods started (menarche)	0.6	1.4	1.6	1.3	-1.1
High blood pressure	0.6	1.6	1.7	1.2	1.3
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.5	-1.6	0.5
Multivitamins +/- minerals	0.6	0.7	1.2	-1.1	0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.7	-0.1	-1.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.5	1.2	-0.1
Heart disease (mother)	0.6	0.8	1.0	1.0	0.7
Leg fat mass (right)	0.6	2.2	4.2	-0.5	2.0
Friendships satisfaction	0.6	0.7	0.8	0.9	-0.8
Qualifications: nursing, teaching	0.6	0.9	1.0	1.0	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	-1.1	-0.1
Number of self-reported non-cancer illnesses	0.6	1.0	1.1	0.9	-1.1
Irritability	0.6	1.1	1.7	-1.3	0.6
Leg fat mass (left)	0.6	2.2	4.1	-0.4	2.0
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.7	1.6	0.4
Worry (Nagel 2018)	0.5	1.1	1.5	0.8	-1.2
Lung FVC	0.5	2.4	4.7	0.4	2.2
Tanning	0.5	6.2	7.2	-2.7	2.3
Angina	0.5	0.7	0.9	-1.0	-0.7
Stomach or abdominal pain in last month	0.5	0.6	1.2	-0.2	1.1
Hair/balding pattern: Pattern 2	0.5	0.7	1.4	-1.2	-0.1
Neuroticism score	0.5	1.0	1.8	-0.6	-1.3
Weight	0.5	2.6	5.1	0.1	2.3
Standing height	0.5	5.1	9.7	3.1	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.2	0.6	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.0	0.6	1.0
Medication: Blood pressure	0.5	0.8	1.0	1.0	0.8
Angina (self-reported)	0.5	0.6	0.6	-0.8	-0.8
Mean time to correctly identify matches	0.5	1.0	1.0	-1.0	1.0
Whole body fat mass	0.5	2.1	4.3	0.0	2.1
Illnesses of siblings: Diabetes	0.5	0.7	0.9	0.6	1.0
Arm fat percentage (left)	0.5	1.9	3.5	-0.4	1.9
Long-standing illness, disability or infirmity	0.5	0.8	1.7	-1.3	0.1
Diabetes diagnosed by doctor	0.5	0.8	1.4	-0.4	1.2
Medication: Aspirin	0.5	0.6	1.1	-1.0	0.4
Guilty feelings	0.5	0.7	1.4	-1.2	0.1
Number of operations (self-reported)	0.5	0.8	1.3	-1.1	0.5
Myopia	0.5	0.7	1.4	0.3	1.2
Pain experienced in last month	0.5	0.9	1.4	0.7	-1.2
Alzheimer’s Disease (in father)	0.4	0.4	0.6	-0.5	-0.8
Major Depression (MDD)	0.4	0.5	0.9	0.2	-1.0
Rheumatoid Arthritis	0.4	0.5	1.0	0.2	-1.0
Heel T-Score	0.4	3.1	6.1	0.1	2.5
Height	0.4	8.4	16.6	4.1	0.5
Ever had hysterectomy (womb removed)	0.4	0.5	0.8	-0.4	0.9
Supplements: Zinc	0.4	0.4	0.8	0.2	0.9
Medication: Metformin	0.4	0.6	0.8	-0.6	0.9
Trunk fat mass	0.4	1.6	2.9	0.5	1.7
Nervous feelings	0.4	0.7	1.3	0.3	-1.1
Qualifications: None of the above	0.4	0.9	0.9	-1.0	0.9
Diabetes (self-reported)	0.4	0.6	1.0	-0.4	1.0
Medication: Simvastatin	0.4	0.6	1.2	0.1	1.1
Hip circumference	0.4	1.9	2.9	-0.9	1.7
Time employed in main current job	0.4	0.5	0.9	1.0	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	-0.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	-1.0	0.0
Illnesses of father: None of the above (group 1)	0.4	0.5	0.8	0.5	0.9
Medication: Lisinopril	0.4	0.5	1.0	1.0	0.0
Medication: Atorvastatin	0.4	0.5	0.9	-0.2	-0.9
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.1	-1.0	-1.0
Depression (Nagel 2018)	0.3	0.4	0.7	0.8	-0.4
Breast Cancer	0.3	0.6	0.7	-0.8	0.7
Respiratory disease	0.3	0.6	1.2	0.0	1.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	0.1	-0.9
Taking other prescription medications	0.3	0.5	0.9	0.2	1.0
Medication: Atenolol	0.3	0.3	0.6	0.2	0.8
High blood pressure (mother)	0.3	0.4	0.6	0.5	0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	-0.8	0.4
Mouth/teeth dental problems	0.3	0.5	0.8	-0.9	-0.4
Arm fat percentage (right)	0.3	1.4	2.6	-0.3	1.6
Falls in the last year	0.3	0.4	0.7	-0.4	0.8
Number of live births	0.3	0.4	0.6	-0.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.8	1.3	0.2
Tense / ‘highly strung’	0.3	0.4	0.7	0.8	-0.4
Hair/balding pattern: Pattern 4	0.3	0.8	1.0	0.7	1.0
Birth weight	0.3	0.6	1.1	-1.0	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.0	1.9	1.4	-0.1
Number of children fathered	0.3	0.3	0.6	0.8	0.1
Comparative height size at age 10	0.3	1.6	2.8	0.6	1.7
Had major operations	0.3	0.4	0.7	-0.8	-0.3
Mother’s age at death	0.3	0.4	0.6	0.3	-0.8
Supplements: Calcium	0.3	0.3	0.5	0.2	0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	-0.8	-0.4
Neuroticism (Nagel 2018)	0.2	0.6	0.9	-1.0	-0.4
Irritable Bowel Disease (IBD)	0.2	0.4	0.4	-0.6	-0.7
Ulcerative Colitis	0.2	0.3	0.7	-0.8	0.1
Blood Platelet Count	0.2	1.8	2.9	-0.9	-1.7
Allergy or Eczema	0.2	0.4	0.6	-0.8	0.4
Hand grip strength (right)	0.2	0.5	0.9	0.2	1.0
Fed-up feelings	0.2	0.3	0.4	-0.7	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.8	0.0
Supplements: Glucosamine	0.2	0.3	0.4	0.3	0.6
Number of incorrect matches in round	0.2	0.3	0.5	-0.1	0.7
Forced vital capacity (FVC)	0.2	0.6	1.2	1.1	-0.1
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.7	-0.3
Heart attack	0.2	0.3	0.6	-0.8	-0.2
Worrier / anxious feelings	0.2	0.3	0.5	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.5	1.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.6	-0.0
High blood pressure (siblings)	0.2	0.3	0.5	0.7	0.0
Pulse rate, automated reading	0.2	0.7	0.7	0.8	0.8
Illnesses of father: Heart disease	0.2	0.3	0.4	-0.6	-0.6
Ever had bowel cancer screening	0.2	0.2	0.4	0.1	0.6
Osteoporosis (self-reported)	0.2	0.2	0.2	0.5	-0.4
Average weekly champagne plus white wine intake	0.2	0.3	0.6	-0.3	-0.8
Ever taken oral contraceptive pill	0.2	0.2	0.3	0.5	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.2	0.4	-0.5
Alcohol drinker status: Never	0.2	0.2	0.2	0.5	-0.4
Average weekly beer plus cider intake	0.2	0.3	0.6	0.3	-0.8
Commuting to job workplace: Cycle	0.2	0.3	0.3	-0.5	-0.6
Crohns Disease (2017)	0.1	0.2	0.3	-0.2	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.5	-0.3
Prostate Cancer	0.1	0.1	0.2	-0.4	0.2
Bipolar Disorder (2011)	0.1	0.0	0.1	0.3	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	0.2
Crohns Disease (2012)	0.1	0.1	0.2	-0.1	-0.4
Blood Red Count	0.1	0.7	0.9	0.7	1.0
Waist Hip Ratio (WHR)	0.1	0.5	0.9	-0.3	1.0
Lung FEV1/FVC ratio	0.1	0.7	1.4	1.2	0.2
Hair Pigment	0.1	3.4	5.2	-2.3	1.3
Hand grip strength (left)	0.1	0.3	0.5	-0.3	0.7
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.2	0.6
Vitamin and mineral supplements	0.1	0.2	0.4	0.6	-0.0
Trunk fat percentage	0.1	0.5	0.8	0.5	0.9
Qualifications: CSEs or equivalent	0.1	0.1	0.1	0.0	-0.4
Alcohol usually taken with meals	0.1	0.1	0.2	0.4	0.3
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.4	0.5
Had menopause	0.1	0.1	0.2	-0.4	0.1
Lung cancer (father)	0.1	0.1	0.3	0.5	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.3	-0.6
Birth weight of first child	0.1	0.1	0.2	-0.1	0.4
Loud music exposure frequency	0.1	0.1	0.2	-0.4	0.4
Headache pain in last month	0.1	0.1	0.2	0.3	0.5
Medication: Amlodipine	0.1	0.2	0.2	0.4	-0.4
Body fat percentage	0.1	0.4	0.9	-0.0	0.9
Leg fat percentage (right)	0.1	0.3	0.4	-0.6	0.4
Worry too long after embarrassment	0.1	0.1	0.2	-0.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.1	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.1	0.4
Mineral and other dietary supplements	0.1	0.1	0.1	0.3	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.4	-0.2
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.6	-0.1
Leg fat percentage (left)	0.1	0.3	0.3	-0.6	0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.1	-0.0	-0.4
Ever depressed for a whole week	0.1	0.1	0.2	-0.5	0.0
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.4	-0.3
Cholesterol lowering medication	0.1	0.2	0.3	-0.6	-0.2
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.5	0.2
LDL Cholesterol	0.0	0.1	0.1	-0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.1	0.1	0.0	-0.3
Had other major operations	0.0	0.0	0.0	-0.1	-0.2
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.2	0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	0.3	-0.0
Asthma	0.0	0.0	0.1	0.3	0.2
Length of working week for main job	0.0	0.0	0.1	-0.1	0.3
Comparative body size at age 10	0.0	0.1	0.1	0.4	0.0
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.0	0.1
Suffer from ‘nerves’	0.0	0.1	0.1	0.1	-0.4
Supplements: Vitamin C	0.0	0.0	0.1	-0.1	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	-0.0	0.0
Asthma (self-reported)	0.0	0.0	0.1	0.3	0.1

Hub : Genes

FAM113A

Models

Trait associations