Hub : Genes

FAM118B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.3030	0.0500	8.6e-12	0.210	NA	0.225	NA	0.239	4.4e-19	NA	1.5e-20	NA	7.0e-22
2	NTR	Blood	0.0241	0.0082	6.3e-04	0.026	0.011	0.022	0.015	0.022	5.8e-09	1.5e-04	8.6e-08	1.0e-05	8.6e-08
3	YFS	Blood	0.0288	0.0088	6.0e-05	0.016	0.013	0.018	0.014	0.021	2.8e-06	2.8e-05	1.0e-06	1.4e-05	1.4e-07
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0740	0.0350	8.1e-04	0.073	0.080	0.083	NA	0.083	5.4e-05	2.4e-05	1.7e-05	NA	1.7e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	2.2	1.1	1.5	0.4	-0.7
Bipolar Disorder or Schizophrenia	0.2	0.4	1.4	0.2	1.2	-0.3	-0.4
Depressed Affect (Nagel 2018)	0.7	1.4	3.7	0.5	0.5	1.2	-1.9
Depression (Nagel 2018)	0.3	0.5	1.5	0.3	0.0	0.7	-1.2
Intelligence (Savage-Jansen 2018)	0.8	2.4	3.4	-1.6	-1.8	-1.8	0.7
Neuroticism (Nagel 2018)	0.9	2.1	4.7	1.0	0.7	1.4	-2.2
Schizophrenia (2018)	0.1	0.2	0.4	-0.7	0.3	-0.6	0.0
Schizophrenia vs Biploar Disorder	0.6	0.8	1.5	-1.1	-0.7	-0.2	-1.2
Worry (Nagel 2018)	0.7	1.4	2.8	1.2	0.8	1.0	-1.7
Alzheimer’s Disease (in mother)	1.2	1.4	4.1	-0.2	1.2	0.4	-2.0
Alzheimer’s Disease (in father)	0.9	1.0	2.0	-1.3	-1.4	-0.5	-0.0
Alzheimer’s Disease (including proxy)	0.5	0.7	1.6	-1.2	-0.6	-0.6	-0.8
Crohns Disease (2017)	0.3	0.6	1.3	-1.2	-0.8	0.1	-0.6
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	0.0	0.6	0.6	-1.1
Ulcerative Colitis (UC)	1.3	2.4	3.2	1.5	1.8	1.2	-1.6
Major Depression (MDD)	0.5	0.6	1.6	0.4	0.1	0.8	-1.3
Reaction Time	0.0	0.0	0.0	0.1	0.0	-0.1	-0.2
Verbal and Numeric Reasoning (VNR)	0.8	2.0	2.5	-1.6	-1.6	-1.3	1.2
Breast Cancer	0.1	0.3	0.7	-0.8	-0.1	0.6	-0.3
Ovarian Cancer	1.1	1.5	2.4	-1.6	-1.4	-1.2	0.2
Prostate Cancer	2.0	2.9	4.2	1.8	1.7	2.0	-1.1
Age at First Birth	1.0	1.5	4.5	2.1	0.7	1.0	0.1
Bipolar Disorder (2011)	1.9	1.8	3.7	1.6	1.9	0.7	-0.6
Body Mass Index (BMI) (2010)	0.4	0.6	1.2	-1.1	-1.0	-0.4	-0.3
Coronary Artery Disease (CAD)	0.6	0.7	1.6	0.3	-1.3	-0.7	0.9
Crohns Disease (2012)	0.8	1.3	3.1	-1.8	-1.1	-0.8	0.4
Mean Putamen Volume	1.1	1.2	2.0	0.6	1.2	1.4	-1.0
Fasting Glucose	0.2	0.2	0.3	-0.1	0.6	0.4	0.5
HbA1C	0.1	0.1	0.3	0.5	0.2	-0.1	0.4
HDL Cholesterol	2.6	4.4	7.5	1.4	2.7	2.0	-2.0
LDL Cholesterol	6.0	9.5	18.1	-2.9	-4.3	-2.4	2.5
Lupus	0.9	1.3	3.8	0.1	2.0	0.5	-1.1
Neuroticism (2016)	1.3	1.8	6.4	-0.4	-0.2	0.9	-2.5
Primary Biliary Cirrhosis	4.4	6.3	8.3	2.7	2.9	2.7	-1.4
Rheumatoid Arthritis	1.0	1.4	3.0	0.9	0.5	1.2	-1.7
Schizophrenia (2014)	0.1	0.3	0.6	-0.2	0.6	-0.3	-0.8
Triglycerides	0.3	0.4	1.0	-1.0	-0.8	-0.2	0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	-0.3	0.6	0.6	-1.3
Ulcerative Colitis	1.7	2.5	4.8	2.2	2.1	1.0	-0.2
Blood Eosinophil Count	5.7	44.0	71.4	4.8	8.4	7.6	-4.9
Blood Platelet Count	1.2	13.5	20.9	3.7	2.5	4.6	-3.6
Blood Red Count	0.5	4.4	9.5	1.3	2.4	3.1	-0.8
Blood White Count	0.6	4.5	9.3	3.0	1.1	2.4	-1.4
Heel T-Score	0.7	5.2	7.6	-1.1	-2.8	-2.5	2.4
BMI	0.2	1.2	2.8	-0.5	-1.2	-0.5	-1.7
Height	0.3	6.0	13.2	-3.6	-0.4	2.4	-2.2
Waist Hip Ratio (WHR)	1.2	5.3	7.3	1.8	2.7	2.4	-2.1
Systolic Blood Pressure	1.4	7.2	10.5	-2.7	-3.0	-3.2	1.3
Smoking Status	0.1	0.2	1.0	-0.1	1.0	0.1	0.1
Allergy or Eczema	0.2	0.5	1.3	-0.4	1.1	0.4	-0.8
Cardiovascular Disease	1.1	3.7	7.1	-1.6	-2.7	-1.8	1.4
Hypothyroidism (self reported)	0.4	1.0	1.9	0.3	-1.1	-0.9	1.4
Respiratory disease	0.7	1.5	2.9	-1.0	1.0	1.1	-1.7
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.9	0.8	1.4	1.0	-0.7
Lung FEV1/FVC ratio	0.3	1.7	5.9	-0.4	0.8	-0.4	2.4
Lung FVC	0.3	1.3	1.8	1.2	1.4	-0.3	1.3
Neuroticism	1.1	2.6	6.0	1.0	1.0	1.6	-2.5
Chronotype (morning person)	0.6	1.4	1.8	1.2	0.9	1.1	-1.3
Hair Pigment	0.1	2.3	3.7	-1.3	-1.2	-1.9	1.6
Tanning	0.3	3.2	5.0	0.8	1.9	2.2	-1.9
Hand grip strength (left)	0.2	0.6	1.2	-1.1	0.5	0.2	0.9
Number of treatments/medications taken	0.8	1.4	3.0	-0.3	-1.7	-1.5	0.3
Average weekly spirits intake	0.6	0.7	1.4	0.7	0.9	0.3	-1.2
Sensitivity / hurt feelings	0.5	0.9	1.2	0.8	1.1	1.0	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	0.7	0.2	0.8	-0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.6	0.7	0.7	-0.2
Relative age of first facial hair	0.3	0.6	1.1	-0.0	-0.9	-1.1	-0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	0.6	-0.1	-0.2	-1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.4	1.2	0.3	0.3	-0.0
Ever had hysterectomy (womb removed)	2.8	3.1	4.2	-1.4	-2.0	-1.9	1.7
Systolic blood pressure, automated reading	1.8	5.1	8.6	-2.2	-2.9	-2.6	0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	0.7	0.0	0.3	0.1
Angina	0.1	0.2	0.3	-0.5	-0.5	-0.1	-0.5
Medication for hormone replacement therapy	0.4	0.4	0.6	-0.8	-0.8	-0.5	-0.5
Vitamin and mineral supplements	0.1	0.2	0.3	0.5	0.1	0.6	-0.1
Supplements: Zinc	0.1	0.1	0.2	-0.5	-0.3	-0.3	-0.0
Medication: Co-codamol	0.4	0.5	1.7	0.3	0.1	-0.2	-1.3
Medication: Metformin	0.2	0.3	0.5	0.6	0.7	0.5	-0.3
Diabetes (father)	2.8	3.4	5.9	0.4	1.8	2.1	-2.4
Diabetes (mother)	1.9	2.4	4.0	0.8	2.0	1.6	-1.5
Severe depression (siblings)	0.8	0.9	2.1	-1.5	-0.4	-0.5	-1.0
Pack years adult smoking proportion	1.5	2.3	3.2	0.3	1.8	1.7	-1.8
Impedance of leg (right)	0.0	0.2	0.4	-0.3	0.6	-0.2	0.6
Leg fat-free mass (left)	0.2	1.1	2.2	-1.5	-1.0	0.5	-1.1
Trunk fat percentage	0.2	0.7	1.8	0.2	-1.0	0.1	-1.4
Hand grip strength (right)	0.2	0.7	1.2	-0.4	1.1	1.0	0.5
Townsend deprivation index at recruitment	1.4	2.0	3.0	-1.1	-1.6	-1.7	1.2
Current tobacco smoking	0.9	1.5	3.8	-0.3	1.0	1.1	-1.9
Average weekly fortified wine intake	0.8	0.9	1.1	1.1	1.1	0.8	-0.9
Maternal smoking around birth	0.1	0.1	0.3	0.4	0.5	-0.3	0.0
Fed-up feelings	0.7	1.3	3.7	0.3	0.4	1.2	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	4.6	0.9	0.7	1.6	-2.2
Relative age voice broke	0.3	0.5	0.8	0.6	0.8	-0.2	-0.9
Taking other prescription medications	0.2	0.3	0.7	0.4	-0.5	-0.2	-0.8
Age when periods started (menarche)	1.5	3.5	5.6	2.0	2.4	2.0	-0.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.2	-0.9	-1.1	-1.0	1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	4.6	-2.0	-2.1	-1.8	1.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.5	-0.6	-0.1	0.4	-1.2
Qualifications: CSEs or equivalent	5.0	6.6	8.3	2.4	2.3	2.6	-2.9
Serious illness, injury or assault to yourself	0.3	0.4	0.7	0.8	0.0	-0.5	0.9
High blood pressure	1.9	5.2	11.2	-1.6	-3.4	-2.3	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.8	-0.4	1.3	0.8	-1.0
Multivitamins +/- minerals	0.3	0.4	1.1	-0.5	0.2	-0.5	1.1
Stomach or abdominal pain in last month	2.0	2.6	6.5	2.5	1.1	1.4	-0.7
Supplements: Glucosamine	0.3	0.5	0.9	-0.6	-0.9	-0.5	0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.1	-0.4	0.1	0.3
Medication: Atenolol	2.3	2.8	4.0	-0.4	-1.8	-2.0	2.0
Medication: Levothyroxine sodium	0.2	0.3	0.8	0.9	-0.2	-0.3	0.5
Sitting height	1.1	7.6	21.5	-4.6	-2.6	-1.4	-0.2
Chronic bronchitis/emphysema (father)	3.2	3.8	8.2	1.1	1.5	1.8	-2.9
High blood pressure (mother)	0.2	0.2	0.3	-0.4	-0.6	0.3	0.5
Body mass index (BMI)	0.1	0.5	1.3	0.4	-1.1	-0.3	-0.6
Impedance of leg (left)	0.0	0.1	0.3	-0.2	0.5	-0.1	0.1
Leg predicted mass (left)	0.2	1.2	2.3	-1.5	-0.9	0.5	-1.2
Trunk fat mass	0.2	0.8	1.6	-0.4	-1.1	0.1	-1.3
Waist circumference	0.1	0.4	1.2	0.1	-0.6	0.3	-1.1
Number of incorrect matches in round	0.4	0.7	1.6	0.8	0.1	0.7	-1.3
Past tobacco smoking	0.4	0.8	1.6	1.3	0.3	0.9	-0.8
Alcohol usually taken with meals	0.2	0.3	0.9	-1.0	-0.3	-0.1	-0.0
Nervous feelings	0.3	0.6	0.9	0.7	0.7	0.6	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	6.5	-0.2	0.8	1.4	-2.5
Hearing difficulty/problems with background noise	0.5	0.8	3.0	-0.2	-0.4	-0.0	1.7
Hair/balding pattern: Pattern 2	0.6	0.8	1.6	1.1	1.3	0.6	-0.2
Had menopause	1.7	2.1	3.3	-0.7	-1.8	-1.5	1.5
Had other major operations	0.4	0.5	1.2	0.3	0.7	0.3	-1.1
Forced vital capacity (FVC)	0.3	1.1	2.6	-1.6	0.1	-0.8	1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	4.5	-2.0	-2.1	-2.0	2.0
Ever unenthusiastic/disinterested for a whole week	2.8	3.4	4.6	-1.5	-2.0	-2.1	1.7
Qualifications: None of the above	0.3	0.7	1.2	1.1	0.8	0.7	-0.7
Financial difficulties in last 2 years	0.1	0.2	0.4	0.3	0.6	0.4	0.1
Mouth/teeth dental problems	0.1	0.2	0.8	-0.9	-0.1	-0.0	0.2
Heart attack	3.2	4.1	7.3	2.7	1.7	2.1	-1.4
Allergy	1.1	2.5	4.3	-0.4	-1.8	-1.5	2.1
Pain all over the body in last month	1.5	1.6	2.9	-1.7	-1.1	-1.1	1.0
Diabetes (self-reported)	0.2	0.3	0.6	0.1	0.8	0.7	-0.1
Hayfever/allergic rhinitis (self-reported)	4.4	5.8	8.4	1.9	2.9	2.4	-2.3
Medication: Ramipril	1.0	1.3	2.5	-0.1	0.5	1.5	-1.6
Medication: Simvastatin	3.7	5.4	9.8	-1.0	-3.1	-2.6	2.0
Fluid intelligence score	1.9	4.0	4.7	-1.8	-2.1	-2.2	1.9
Illnesses of siblings	0.4	0.5	1.5	-0.6	0.2	-0.5	1.2
Neuroticism score	2.5	5.3	10.5	1.4	1.7	2.4	-3.2
Weight	0.3	1.3	2.4	-1.3	-1.6	-0.1	-0.9
Impedance of arm (right)	0.1	0.4	0.9	0.3	0.7	0.4	-0.9
Arm fat percentage (right)	0.2	0.7	1.0	0.9	-0.9	-0.2	-1.0
Trunk fat-free mass	0.5	2.6	7.6	-2.8	-1.6	-0.6	0.1
Hip circumference	0.3	1.2	3.5	-0.8	-1.9	-0.6	-0.5
Time employed in main current job	0.2	0.2	0.6	-0.0	0.3	-0.0	-0.8
Alcohol intake versus 10 years previously	1.1	1.7	4.1	0.1	0.4	1.6	-2.0
Father’s age at death	0.5	0.6	1.3	1.0	0.2	0.2	1.2
Worrier / anxious feelings	0.6	1.2	1.7	1.0	1.0	1.0	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.0	0.0	0.4	-0.4
Falls in the last year	0.1	0.1	0.3	0.2	0.2	0.3	-0.6
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.0	0.1	-0.3	-0.5
Number of live births	0.3	0.4	1.5	0.1	0.3	-0.2	1.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.2	-1.2	0.2	-0.6	1.5
Pulse rate	1.0	1.6	2.7	1.2	1.5	1.6	-0.3
Happiness	0.8	0.9	2.0	0.8	0.4	0.9	-1.4
Noisy workplace	0.6	0.8	1.3	0.5	0.7	1.0	-1.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.6	-0.6	-0.1	0.0	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.2	-0.9	-0.6	0.2
Mouth/teeth dental problems: Dentures	0.4	0.7	1.4	-0.2	-0.7	-1.1	1.2
Asthma	1.0	2.0	3.2	0.2	1.4	1.8	-1.6
Medication: Ibuprofen (e.g. Nurofen)	4.6	5.9	6.4	2.5	2.4	2.5	-2.3
Medication: Cholesterol lowering	3.5	5.4	9.9	-1.0	-3.2	-2.4	2.3
Depression (self-reported)	1.6	1.9	5.9	0.1	0.7	1.1	-2.4
Medication: Lansoprazole	1.1	1.3	2.6	-1.1	-1.6	-1.1	0.4
Prospective memory result	2.1	2.6	4.2	1.6	1.5	1.1	-2.0
Lung cancer (father)	0.0	0.0	0.1	-0.0	0.1	-0.0	0.3
Illnesses of mother	2.0	2.5	3.5	-1.5	-1.8	-1.9	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.9	-1.1	0.2	-0.7	1.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.4	-0.1	0.5	-0.1
Impedance of arm (left)	0.1	0.3	0.5	0.2	0.7	0.6	-0.4
Arm fat mass (right)	0.2	0.8	2.2	-0.1	-1.5	-0.5	-0.8
Trunk predicted mass	0.4	2.5	7.5	-2.7	-1.5	-0.5	0.1
Standing height	0.4	4.1	14.6	-3.8	-1.1	0.4	-0.5
Length of working week for main job	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.1
Exposure to tobacco smoke at home	1.1	1.2	2.6	1.1	0.5	0.8	-1.6
Breastfed as a baby	3.0	3.7	6.9	-0.8	-1.8	-2.1	2.6
Tense / ‘highly strung’	2.1	3.5	5.5	1.6	1.8	1.6	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.1	-0.3	0.2	-1.0
Hair/balding pattern: Pattern 4	3.1	7.4	11.1	-3.3	-3.0	-2.3	2.0
Birth weight of first child	4.4	7.9	9.1	-2.9	-2.4	-3.0	2.9
Peak expiratory flow (PEF)	0.3	0.7	1.3	-0.5	1.1	0.9	0.8
Pulse wave reflection index	0.5	0.7	1.5	-0.3	-0.6	-1.2	0.9
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.1	-0.0	0.4	-0.1
Loud music exposure frequency	0.6	0.7	1.2	-1.1	-0.9	-0.9	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.9	-0.7	-0.6	-0.9	0.8
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.6	0.8	0.0	0.1	-0.1
Blood clot in the leg (DVT)	0.2	0.2	0.8	0.9	0.2	0.4	0.1
Medication: Paracetamol	0.1	0.2	0.4	0.6	-0.3	-0.4	0.2
Headache pain in last month	0.4	0.6	1.0	1.0	0.3	1.0	-0.7
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	5.2	0.8	2.3	1.6	-1.7
Glaucoma (self-reported)	1.1	1.3	2.4	1.1	1.5	1.2	-0.4
Gout (self-reported)	1.5	2.1	5.3	0.7	-0.9	-1.4	2.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	0.7	-0.3	-0.2	0.7
Medication: Amlodipine	0.1	0.1	0.3	0.3	-0.6	-0.1	0.1
Medication: Ventolin 100micrograms inhaler	1.5	1.9	7.2	-0.5	-0.0	0.2	-2.7
Birth weight	0.3	0.7	1.6	-1.3	0.2	-0.1	-1.0
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.3	1.8	1.2	0.9	0.2
High blood pressure (siblings)	0.5	0.8	0.9	-0.9	-0.9	-0.7	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.2	3.0	-1.7	-0.2	-0.8	1.0
Body fat percentage	0.2	0.6	1.4	0.4	-1.0	-0.1	-1.2
Leg fat percentage (right)	0.1	0.5	0.9	0.6	-1.0	-0.4	-0.7
Arm fat-free mass (right)	0.4	1.9	5.3	-2.3	-1.4	-0.1	-0.4
Exposure to tobacco smoke outside home	0.2	0.2	0.8	0.0	-0.9	0.1	-0.4
Comparative body size at age 10	3.7	10.2	15.5	-2.4	-3.9	-3.6	2.6
Number of full brothers	1.4	1.8	3.2	1.6	1.8	0.9	-0.8
Worry too long after embarrassment	0.9	1.5	2.3	0.8	1.2	1.2	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.2	-0.1	-0.2	-0.6
Wheeze or whistling in the chest in last year	2.9	5.2	6.6	1.6	2.3	2.5	-2.6
Number of children fathered	3.8	4.3	14.4	-0.5	0.8	1.3	-3.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.2	1.1	1.1	0.2	0.3
Age at first live birth	0.2	0.4	0.9	0.2	0.5	0.5	-0.9
Pulse wave peak to peak time	0.3	0.4	1.0	-1.0	-0.3	-0.7	0.2
Health satisfaction	1.0	1.4	3.0	-1.4	-0.6	-0.3	-1.7
Shortness of breath walking on level ground	1.4	1.7	3.9	-2.0	-1.6	-0.4	-0.1
Qualifications: College or University degree	0.1	0.4	1.0	-1.0	-0.5	-0.6	0.2
Eye problems/disorders: None of the above	0.5	0.6	1.4	-1.2	-0.4	-0.7	-0.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.1	-0.9	-0.6	-1.2	1.4
Emphysema/chronic bronchitis	0.5	0.6	2.3	0.1	-0.1	0.1	-1.5
Medication for pain relief, constipation, heartburn	0.7	1.2	4.4	-2.1	-0.4	-0.2	0.4
Neck or shoulder pain in last month	2.0	2.9	4.1	1.2	1.5	2.0	-1.9
Medication: Blood pressure	0.6	1.1	1.9	-0.2	-1.1	-1.0	1.4
Angina (self-reported)	0.2	0.2	0.7	-0.4	-0.2	0.1	-0.9
Migraine (self-reported)	0.3	0.3	0.9	-1.0	-0.4	-0.0	-0.5
Medication: Ibuprofen	4.6	5.5	6.0	2.4	2.4	2.5	-2.1
Medication: Allopurinol	1.4	1.8	4.5	0.2	-1.1	-1.2	2.1
Medication: Omeprazole	0.1	0.2	0.5	0.2	-0.1	-0.3	-0.7
Medication: Seretide 50 evohaler	0.7	0.8	3.2	-0.1	-0.0	0.2	-1.8
Mean time to correctly identify matches	0.2	0.4	0.8	-0.2	-0.7	-0.9	0.5
Heart disease (mother)	0.5	0.6	1.5	1.2	0.1	0.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	-0.3	-0.3	0.4	-0.3
Whole body fat mass	0.2	0.7	1.6	-0.4	-1.3	-0.2	-1.0
Leg fat mass (right)	0.1	0.6	1.2	-0.0	-1.1	-0.1	-1.0
Arm predicted mass (right)	0.4	2.1	5.6	-2.4	-1.6	-0.4	-0.1
Pulse rate, automated reading	0.2	0.5	1.3	0.4	0.7	1.1	-0.1
Alcohol intake frequency.	0.5	1.1	2.6	-1.1	-1.6	-0.6	-0.5
Comparative height size at age 10	0.7	4.0	13.7	-3.7	-1.4	-0.3	0.5
Number of full sisters	1.1	1.3	1.9	1.4	1.0	1.1	-1.0
Suffer from ‘nerves’	1.2	1.9	5.8	0.5	0.9	0.9	-2.4
Overall health rating	0.4	0.9	1.7	-0.6	-1.3	-1.2	0.3
Chest pain or discomfort	0.4	0.6	1.2	0.4	-1.1	-0.1	1.0
Had major operations	1.9	2.2	4.7	2.2	1.3	1.4	-0.7
Age at last live birth	0.4	0.5	0.9	0.5	0.7	0.7	-0.9
Family relationship satisfaction	0.3	0.4	0.8	0.6	0.5	0.9	-0.3
Leg pain on walking	0.6	0.8	2.8	0.6	0.3	0.3	-1.7
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	3.5	-1.7	-1.9	-1.4	1.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	1.9	1.2	1.1	1.4	-0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.0	0.4	0.4	1.0	0.1
Medication: Aspirin	2.2	2.8	5.1	-0.5	-1.9	-1.6	2.3
Supplements: Vitamin C	4.0	4.7	10.7	1.3	1.9	1.7	-3.3
Knee pain experienced in last month	0.3	0.5	1.4	-0.3	0.4	0.4	-1.2
Hypertension (Self-reported)	1.5	4.1	8.7	-1.4	-3.0	-2.1	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.4	-0.2	-0.6	-0.2	-0.4
Illnesses of father: Heart disease	1.4	2.0	3.3	0.3	-1.6	-1.5	1.8
Illnesses of siblings: Diabetes	0.8	1.0	3.6	0.4	0.1	0.5	-1.9
Smoking status: Previous	1.0	1.5	2.2	-1.3	-0.6	-1.4	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.3	-1.5	-0.6	0.3	-0.4
Whole body fat-free mass	0.4	2.0	5.8	-2.4	-1.5	-0.2	-0.4
Leg fat-free mass (right)	0.3	1.4	2.3	-1.5	-0.9	0.7	-1.4
Arm fat percentage (left)	0.1	0.5	0.9	0.8	-0.9	-0.3	-0.7
Average weekly red wine intake	1.0	1.4	2.3	0.6	1.1	1.5	-1.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.4	0.5	0.3	0.0
Mood swings	3.9	7.1	14.6	0.9	2.2	2.8	-3.8
Loneliness, isolation	0.2	0.2	0.9	0.0	0.3	0.1	-0.9
Long-standing illness, disability or infirmity	0.5	0.8	1.1	-0.6	-0.9	-0.8	1.1
Ever had bowel cancer screening	3.1	3.6	5.1	-1.2	-1.9	-2.1	2.3
Diabetes diagnosed by doctor	0.0	0.1	0.2	0.0	0.4	0.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.3	0.5	0.1	-0.1
Friendships satisfaction	0.5	0.7	1.3	-1.0	-0.6	-0.2	-1.1
Qualifications: nursing, teaching	0.7	1.1	2.7	-1.6	-1.1	-0.6	0.5
Commuting to job workplace: Walk	0.8	0.9	2.6	-0.5	-0.5	-0.6	1.6
Eye problems/disorders: Cataract	0.6	0.7	1.4	0.8	1.0	1.2	-0.0
Mouth/teeth dental problems: Mouth ulcers	4.8	7.7	8.7	2.6	2.7	2.8	-2.9
Medication for cholesterol	1.5	2.3	5.3	0.9	2.3	1.4	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	0.5	0.9	0.1	0.1
Back pain experienced in last month	0.4	0.5	1.5	0.5	0.5	0.3	-1.2
Mineral and other dietary supplements	0.5	0.6	0.9	-0.9	-0.8	-0.8	0.6
Breast cancer (self-reported)	0.3	0.4	0.8	-0.5	-0.7	-0.9	0.3
Asthma (self-reported)	1.6	3.2	5.0	0.6	1.9	2.2	-2.0
Osteoporosis (self-reported)	0.4	0.5	1.9	-0.3	-0.2	-0.0	-1.4
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.8	0.7	0.4	0.3
Medication: Aspirin	1.1	1.4	2.3	-0.4	-1.5	-1.0	1.5
Medication: Gliclazide	0.6	0.7	1.0	1.0	1.0	0.9	-0.2
Illnesses of father: None of the above (group 1)	1.0	1.3	2.6	0.9	1.6	1.2	-0.2
Smoking status: Current	1.0	1.7	3.9	-0.1	1.1	1.2	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	0.2	0.7	-0.1	-0.6
Whole body water mass	0.3	1.9	5.3	-2.3	-1.4	-0.1	-0.4
Leg predicted mass (right)	0.2	1.3	2.2	-1.5	-0.9	0.6	-1.3
Arm fat mass (left)	0.2	0.7	2.2	-0.1	-1.5	-0.5	-0.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.1	-0.7	-0.2	-0.5
Average weekly champagne plus white wine intake	0.7	1.0	2.3	-1.5	-0.9	-0.8	0.2
Miserableness	2.7	4.8	9.7	1.0	1.7	2.3	-3.1
Guilty feelings	0.6	0.9	1.4	0.6	1.0	1.0	-1.2
Wears glasses or contact lenses	0.1	0.1	0.2	-0.5	-0.0	0.1	0.1
Ever taken oral contraceptive pill	0.9	1.0	2.0	0.0	1.2	1.4	0.7
Hearing aid user	1.7	1.9	4.4	2.1	1.2	1.3	0.5
Mother’s age at death	0.2	0.2	0.7	0.5	-0.1	-0.1	0.9
Financial situation satisfaction	0.2	0.3	0.8	-0.9	-0.3	0.3	-0.4
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.6	-0.6	0.4	0.1	1.3
Commuting to job workplace: Public transport	1.1	1.3	2.4	-0.4	-0.9	-1.3	1.5
Eye problems/disorders: Glaucoma	1.8	2.2	2.9	1.7	1.7	1.6	-0.6
Medication: Blood pressure	1.5	2.8	5.6	-1.2	-2.4	-1.8	0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.9	1.4	0.5	0.7	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.4	0.7	1.2	0.8	-0.8
High cholesterol (Self-reported)	3.4	6.1	11.8	-1.2	-3.4	-2.7	2.0
Medication: Bendroflumethiazide	0.3	0.5	1.0	0.4	-0.5	-0.9	1.0
Medication: Paracetamol	0.2	0.2	0.4	0.5	-0.6	-0.6	0.2
Medication: Lisinopril	4.4	5.7	8.5	-1.9	-2.1	-2.9	2.5
Medication: Atorvastatin	0.4	0.5	1.3	-0.7	-1.2	-0.3	0.2
Illnesses of father: High blood pressure	0.7	0.9	2.0	-1.1	-1.4	-0.7	-0.1
Alcohol drinker status: Never	0.8	0.9	1.9	0.7	0.8	1.4	-0.9
Ever smoked	0.8	1.4	4.2	-2.0	-0.8	-0.9	0.5
Basal metabolic rate	0.3	1.7	4.3	-2.1	-1.4	-0.1	-0.6
Leg fat percentage (left)	0.2	0.6	1.1	0.6	-1.0	-0.3	-1.0
Arm fat-free mass (left)	0.4	1.8	4.7	-2.2	-1.6	-0.2	-0.3
Number of operations (self-reported)	2.2	3.2	4.9	1.6	1.4	1.8	-2.2
Average weekly beer plus cider intake	0.4	0.5	1.5	1.2	0.6	-0.1	0.3
Irritability	1.8	3.1	4.4	1.8	1.7	2.1	-1.3
Risk taking	1.0	1.5	2.6	-1.6	-1.1	-1.0	1.1
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	-0.7	-0.4	0.4	-0.6
Fractured/broken bones in last 5 years	1.1	1.4	2.5	-1.6	-1.1	-1.2	0.7
Age started oral contraceptive pill	0.3	0.3	0.5	0.1	-0.7	-0.7	0.6
Diastolic blood pressure, automated reading	1.0	3.0	5.2	-1.7	-2.3	-1.7	0.8
Ever depressed for a whole week	1.7	2.2	3.4	-0.7	-1.7	-1.9	1.3
Unable to work because of sickness or disability	0.4	0.5	1.2	-0.1	0.8	1.1	-0.3
Commuting to job workplace: Cycle	0.7	0.8	1.5	1.1	1.2	0.7	0.1
Myopia	0.6	0.9	1.8	0.3	-1.0	-0.7	1.3
Vascular/heart problems diagnosed by doctor	1.3	3.5	8.3	1.4	2.9	1.8	-0.8
Cholesterol lowering medication	0.3	0.4	1.5	-0.1	-1.2	-0.4	0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.5	0.4	-0.1	0.1	-0.7
Pain experienced in last month	0.5	0.9	2.1	-0.8	-0.3	-0.9	1.4
Supplements: Calcium	0.2	0.2	0.7	0.8	0.1	0.3	-0.2
Basal cell carcinoma (self-reported)	1.5	1.8	2.3	-1.1	-1.4	-1.3	1.5
Heart attack/myocardial infarction (self-reported)	2.9	3.8	7.0	2.6	1.6	1.9	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.4	1.2	0.4	0.8	-0.4
Heart disease (siblings)	0.1	0.2	0.5	0.7	0.0	0.3	0.1
Alcohol drinker status: Previous	4.3	4.9	7.1	-2.7	-2.6	-2.4	0.2
Pack years of smoking	1.0	1.5	2.2	0.4	1.5	1.4	-1.3
Impedance of whole body	0.0	0.2	0.5	-0.1	0.7	0.4	-0.3
Leg fat mass (left)	0.2	0.6	1.3	-0.0	-1.1	-0.1	-1.1
Arm predicted mass (left)	0.4	2.2	5.2	-2.3	-1.8	-0.6	-0.0