Hub : Genes

FAM124B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0430 0.0180 3.4e-03 0.059 0.015 0.054 0.023 0.057 9.5e-08 5.6e-03 3.3e-07 7.8e-04 1.7e-07
2 GTEx Adipose Subcutaneous 0.0760 0.0330 5.5e-03 -0.002 NA -0.003 NA -0.002 4.8e-01 NA 6.7e-01 NA 4.6e-01
3 GTEx Adrenal Gland 0.3113 0.0944 1.5e-04 0.170 NA 0.094 NA 0.172 1.1e-06 NA 3.1e-04 NA 9.2e-07
4 GTEx Heart Left Ventricle 0.1254 0.0562 5.5e-03 0.049 NA 0.030 NA 0.043 1.3e-03 NA 1.0e-02 NA 2.3e-03
5 METSIM Adipose 0.0418 0.0186 2.0e-03 0.007 0.022 0.008 0.023 0.010 2.3e-02 2.5e-04 1.9e-02 2.0e-04 1.0e-02
6 YFS Blood 0.0603 0.0178 1.4e-07 0.043 0.027 0.048 0.053 0.047 4.5e-14 2.5e-09 1.5e-15 9.0e-17 3.2e-15
7 TCGA Colon Adenocarcinoma 0.1190 0.0560 7.2e-03 0.053 0.013 0.033 NA 0.035 5.2e-04 5.9e-02 5.4e-03 NA 3.9e-03
8 TCGA Lung Adenocarcinoma 0.0624 0.0339 9.7e-04 0.035 0.032 0.021 NA 0.028 5.4e-05 1.1e-04 1.3e-03 NA 2.6e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.1 0.1 0.8 0.4 -0.9 0.0 0.0 -0.2 -0.0 -0.1 0.4
Bipolar Disorder or Schizophrenia 1.3 3.1 10.3 -0.8 -3.2 -2.2 0.9 -1.5 -0.1 -2.4 0.6
Depressed Affect (Nagel 2018) 0.6 1.2 3.8 -1.3 0.2 -1.0 -1.3 -0.8 1.9 -0.7 -0.9
Depression (Nagel 2018) 0.5 0.7 2.1 -0.6 0.6 -0.8 -0.1 -1.0 1.4 -0.9 -0.5
Intelligence (Savage-Jansen 2018) 2.1 6.4 13.3 -0.1 3.2 3.2 2.4 3.6 -0.8 2.3 2.3
Neuroticism (Nagel 2018) 0.6 1.4 8.9 0.7 0.1 -0.6 -1.0 0.1 3.0 0.2 -0.4
Schizophrenia (2018) 2.1 4.5 11.7 -1.3 -3.4 -2.9 1.2 -1.8 -0.1 -3.0 0.4
Schizophrenia vs Biploar Disorder 1.0 1.3 6.0 -1.1 -0.3 -0.5 0.3 0.3 -2.5 -1.4 -0.6
Worry (Nagel 2018) 0.9 1.9 8.0 2.1 -0.5 -0.5 -1.1 0.5 2.8 1.0 -0.1
Alzheimer’s Disease (in mother) 0.5 0.6 2.2 -1.5 -0.4 -0.5 -0.6 -0.7 0.1 -1.1 -0.4
Alzheimer’s Disease (in father) 0.3 0.4 1.3 0.1 -1.1 -0.0 -1.1 -0.2 0.5 0.0 0.3
Alzheimer’s Disease (including proxy) 0.1 0.2 0.7 -0.6 0.0 0.1 -0.8 -0.4 0.6 -0.4 -0.0
Crohns Disease (2017) 0.6 1.4 3.0 -0.7 -1.7 -0.6 -0.9 -1.3 -1.7 -1.2 -0.5
Irritable Bowel Disease (IBD) 0.6 1.5 3.6 0.1 -1.3 -1.6 -1.5 -1.9 -0.5 -0.8 -1.1
Ulcerative Colitis (UC) 0.6 1.0 2.5 0.9 -0.0 -1.5 -1.3 -1.6 0.1 0.3 -1.1
Major Depression (MDD) 0.9 1.1 3.3 -0.3 -1.8 -1.6 0.1 -0.2 0.5 -1.3 -1.0
Reaction Time 0.7 1.3 3.7 -1.6 -1.9 -0.4 0.0 -0.1 -0.7 -1.9 0.2
Verbal and Numeric Reasoning (VNR) 2.4 5.7 16.0 0.0 3.0 3.2 1.5 4.0 -0.5 2.4 1.6
Breast Cancer 0.2 0.5 2.0 0.3 0.8 0.6 -0.6 0.4 1.4 0.4 -0.4
Ovarian Cancer 0.4 0.6 2.5 -1.6 0.0 -0.0 0.0 -0.0 -1.4 -0.3 -0.4
Prostate Cancer 0.6 0.9 2.9 1.7 1.4 0.4 0.3 0.2 0.2 1.3 0.5
Age at First Birth 0.7 1.0 2.9 1.2 0.1 -0.5 -1.7 0.2 0.9 1.0 -1.3
Bipolar Disorder (2011) 0.3 0.3 1.1 0.7 -1.1 -0.4 0.3 -0.3 0.7 -0.3 -0.2
Body Mass Index (BMI) (2010) 0.7 1.0 2.2 -1.3 1.0 1.5 1.3 0.5 -1.2 -0.0 0.1
Coronary Artery Disease (CAD) 0.8 1.0 3.2 -0.1 1.8 0.9 0.8 0.4 1.4 0.5 0.8
Crohns Disease (2012) 0.3 0.5 2.5 -0.1 -0.6 0.4 -0.2 -1.0 -1.6 0.3 0.3
Mean Putamen Volume 0.3 0.3 1.6 -0.4 -1.3 -0.2 -0.4 0.0 -0.3 -0.4 -0.4
Fasting Glucose 2.0 2.4 6.0 -1.9 -1.8 -0.8 1.2 -0.2 -2.1 -2.5 0.1
HbA1C 1.1 1.2 4.6 -0.5 -0.9 -0.8 -1.5 -2.1 -0.4 0.2 -0.9
HDL Cholesterol 0.2 0.4 1.4 0.1 -0.7 0.5 1.2 0.7 -0.4 0.2 0.5
LDL Cholesterol 0.4 0.7 1.0 1.0 -0.7 0.1 0.8 1.0 1.0 0.8 1.0
Lupus 0.3 0.5 2.0 -0.5 0.0 -0.6 0.1 -0.7 -1.4 -0.7 -0.5
Neuroticism (2016) 1.4 2.0 4.4 -0.7 -1.8 -2.1 -1.1 -0.4 0.5 -1.9 -1.6
Primary Biliary Cirrhosis 0.3 0.4 2.1 -0.0 0.4 -0.1 -0.4 -0.9 -1.4 0.5 -0.2
Rheumatoid Arthritis 0.4 0.6 2.0 0.0 -1.4 -0.3 0.7 -0.2 1.1 -0.5 0.7
Schizophrenia (2014) 2.1 4.7 10.8 -2.5 -3.1 -2.4 1.0 -1.7 -0.9 -3.3 -0.0
Triglycerides 0.7 1.1 4.3 -0.5 1.4 0.1 -2.1 -0.4 0.9 0.6 -1.0
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.8 -0.3 -0.4 -0.2 -0.4 -0.5 0.9 -0.5 -0.7
Ulcerative Colitis 0.8 1.1 3.7 0.9 -0.6 -1.3 -1.2 -1.9 -0.4 0.4 -0.8
Blood Eosinophil Count 0.4 3.0 5.8 1.8 0.9 1.7 2.4 0.8 0.3 2.3 2.3
Blood Platelet Count 0.9 10.8 22.8 0.0 4.8 4.2 2.7 3.6 -1.0 4.5 2.1
Blood Red Count 0.2 1.5 5.2 -0.9 1.2 -0.4 -1.5 -0.4 -0.5 -1.1 -2.3
Blood White Count 0.6 4.3 9.5 0.8 0.5 3.1 3.0 2.5 -0.3 1.2 2.7
Heel T-Score 0.3 2.1 6.8 2.2 -2.6 -1.8 -0.8 -0.9 -0.3 0.1 -0.6
BMI 0.4 2.1 5.2 -0.3 2.0 2.3 1.1 0.5 1.1 1.7 1.6
Height 1.6 30.4 62.6 -0.5 -7.8 -7.9 -6.3 -5.2 -3.5 -4.2 -4.9
Waist Hip Ratio (WHR) 0.9 4.3 10.8 1.1 1.4 3.1 -0.2 1.9 -2.1 3.3 1.5
Systolic Blood Pressure 1.6 8.0 15.1 2.4 3.9 3.5 1.0 3.6 -1.3 3.7 1.4
Smoking Status 1.5 3.6 11.6 -3.4 -1.5 -1.8 0.4 -2.4 -0.6 -2.2 -0.8
Allergy or Eczema 0.1 0.3 1.2 -0.7 0.3 -0.6 -0.2 -0.4 -0.1 -0.2 -1.1
Cardiovascular Disease 1.1 3.6 11.0 0.3 3.3 2.8 0.1 1.2 0.3 2.8 0.8
Hypothyroidism (self reported) 0.2 0.5 1.3 0.5 -0.8 -0.1 0.7 0.9 1.1 0.2 0.4
Respiratory disease 0.5 1.1 2.7 1.5 0.7 1.2 0.2 0.5 0.3 1.6 1.3
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.6 0.3 -0.7 -1.0 -1.2 -1.6 -1.5 0.5 -0.9
Lung FEV1/FVC ratio 0.3 1.7 8.1 0.3 -0.6 0.8 1.2 0.9 2.8 0.3 1.6
Lung FVC 0.9 4.7 14.7 -0.3 -3.8 -1.6 3.1 -0.1 -1.5 -2.5 1.2
Neuroticism 0.4 1.0 4.7 -0.1 0.3 -0.4 -1.6 0.4 2.2 0.4 -0.6
Chronotype (morning person) 1.4 3.1 6.5 -2.5 2.2 -0.6 -2.5 -1.2 -0.3 -0.9 -2.2
Hair Pigment 0.2 5.8 17.1 -0.9 -3.2 -3.2 -1.1 -1.7 -0.5 -4.1 -2.0
Tanning 0.0 0.5 1.4 0.3 -1.2 -0.7 0.4 -0.6 0.2 0.1 1.1
Hand grip strength (left) 0.7 1.8 6.4 1.2 -1.9 -2.5 -0.8 -0.6 -0.5 -0.1 -1.4
Number of treatments/medications taken 0.6 1.1 3.7 -0.1 1.4 0.7 -0.5 0.7 1.9 1.2 0.5
Average weekly spirits intake 0.6 0.7 3.1 -1.8 -0.2 0.3 0.9 0.3 0.8 -0.9 0.1
Sensitivity / hurt feelings 1.1 1.9 4.3 1.9 -0.1 0.6 1.6 1.4 2.1 0.6 1.4
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.6 -1.6 0.7 -1.0 -0.1 -0.7 0.2 -1.5 -0.6
Hearing difficulty/problems: Yes 1.3 1.9 6.4 -0.5 2.5 2.0 0.3 1.3 0.6 1.4 0.9
Relative age of first facial hair 0.3 0.6 2.1 1.1 -0.8 -0.4 0.6 1.4 -0.8 0.1 -0.1
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.7 -0.8 0.3 0.1 0.1 -0.1 0.7 0.1 0.4
Ever used hormone-replacement therapy (HRT) 1.8 2.3 7.6 -0.8 2.8 2.1 0.5 2.0 0.0 1.1 0.8
Ever had hysterectomy (womb removed) 0.6 0.7 1.5 1.0 0.0 0.8 0.6 1.1 -0.7 1.2 0.6
Systolic blood pressure, automated reading 1.9 5.5 12.1 2.4 2.6 2.8 1.2 3.5 -1.1 2.4 1.8
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 2.4 1.3 0.8 0.5 -0.3 -0.5 -1.0 1.5 -0.6
Angina 1.7 2.2 8.5 -1.5 2.9 2.0 1.0 0.7 -0.4 0.8 0.6
Medication for hormone replacement therapy 0.5 0.6 2.8 -1.7 0.7 0.4 0.6 0.6 0.4 -0.3 0.0
Vitamin and mineral supplements 0.4 0.5 1.5 -0.8 0.6 -0.2 0.3 0.4 -1.1 -0.3 -1.2
Supplements: Zinc 0.1 0.1 0.4 0.4 0.2 0.7 -0.0 -0.5 -0.1 -0.0 0.5
Medication: Co-codamol 0.6 0.7 4.1 0.7 -0.1 -0.2 1.0 0.1 2.0 0.5 0.3
Medication: Metformin 0.5 0.8 3.3 0.6 -0.5 0.2 -0.9 -0.1 -1.8 0.9 -0.7
Diabetes (father) 0.4 0.4 1.7 0.4 -1.3 -1.1 0.2 -0.1 -0.1 -0.6 -0.2
Diabetes (mother) 1.3 1.7 5.5 0.4 2.3 1.7 -1.0 -0.0 -0.8 1.7 0.8
Severe depression (siblings) 0.6 0.6 1.6 0.2 0.1 1.2 1.2 -0.0 0.1 0.9 1.3
Pack years adult smoking proportion 1.7 2.5 7.6 -0.2 -0.7 1.5 2.8 2.4 1.1 -0.3 1.7
Impedance of leg (right) 0.7 3.6 10.8 -0.1 3.3 2.6 -0.8 1.9 -1.6 2.1 0.3
Leg fat-free mass (left) 1.8 9.3 22.9 -0.8 -4.8 -4.6 -1.5 -2.9 0.4 -3.7 -2.3
Trunk fat percentage 0.5 1.9 5.4 -0.7 2.3 1.8 1.1 1.8 0.5 0.9 0.7
Hand grip strength (right) 0.6 1.6 5.2 -0.3 -1.8 -2.3 -0.8 -0.7 -1.0 -0.9 -1.3
Townsend deprivation index at recruitment 1.1 1.5 5.7 -1.1 -0.8 0.3 2.4 1.1 0.8 0.1 1.6
Current tobacco smoking 0.8 1.3 2.9 -1.7 -1.2 -1.4 1.1 -1.2 0.5 -1.1 -0.1
Average weekly fortified wine intake 1.1 1.3 4.6 -0.4 -0.7 -0.0 -2.1 -1.4 -1.0 0.3 -1.4
Maternal smoking around birth 1.2 1.7 11.0 -3.3 -0.1 -0.1 -0.4 -0.8 0.2 -1.3 -0.5
Fed-up feelings 0.4 0.8 2.9 -1.7 -0.0 -0.6 -0.3 -1.1 0.8 -1.1 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 5.4 -1.5 -1.1 -1.7 -0.1 -1.6 1.2 -2.3 -0.8
Relative age voice broke 0.4 0.7 2.5 -0.1 -0.7 -1.0 -1.6 -0.6 -0.2 -0.3 -1.0
Taking other prescription medications 0.5 0.8 2.8 -0.5 1.6 0.1 -0.6 -0.2 1.7 0.3 -0.0
Age when periods started (menarche) 0.5 1.1 2.0 -1.0 -0.8 -1.4 -0.7 -1.0 -1.0 -1.3 -1.1
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.6 0.8 -0.4 -0.0 -0.2 0.1 0.4 0.5 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.0 0.8 -0.8 -0.0 0.7 0.3 -1.0 0.3 0.7
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.6 1.6 0.1 0.3 0.4 0.3 0.6 1.2 0.9
Qualifications: CSEs or equivalent 0.4 0.6 1.5 0.6 1.0 0.9 0.9 0.1 -0.3 -0.3 1.2
Serious illness, injury or assault to yourself 0.4 0.5 1.1 -0.9 0.8 0.3 -1.0 0.2 0.7 -1.0 -0.4
High blood pressure 1.4 3.8 9.5 1.1 3.1 2.8 -0.6 1.8 0.1 2.8 0.6
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.4 -1.2 0.7 -0.8 -0.1 -1.0 -0.1 -0.6 -1.1
Multivitamins +/- minerals 1.6 2.0 8.1 1.1 0.4 1.5 1.3 0.4 1.0 1.3 2.8
Stomach or abdominal pain in last month 3.3 4.1 11.1 -0.2 -3.3 -2.3 -1.1 -1.1 2.6 -2.4 -1.1
Supplements: Glucosamine 0.4 0.6 1.4 -0.7 -0.6 -0.7 -1.2 -1.0 -0.1 -0.9 0.3
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.5 0.2 -0.5 -0.5 -0.6 -1.2 0.6 -0.3 -0.0
Medication: Atenolol 0.7 0.9 3.2 -0.6 1.8 1.1 0.5 -0.4 -0.4 1.3 0.3
Medication: Levothyroxine sodium 0.5 0.8 1.8 1.4 -0.8 0.6 0.1 -0.7 0.9 0.8 1.3
Sitting height 3.7 26.0 53.0 -2.6 -7.3 -7.2 -3.8 -4.7 -2.3 -6.2 -4.0
Chronic bronchitis/emphysema (father) 0.3 0.4 1.2 -1.1 0.8 0.3 -0.6 -0.3 -0.6 -0.3 -0.3
High blood pressure (mother) 0.7 1.0 5.1 0.8 2.2 0.8 -0.4 0.1 0.5 1.0 0.3
Body mass index (BMI) 0.4 1.9 3.6 0.2 1.9 1.6 1.1 0.6 1.9 1.4 1.2
Impedance of leg (left) 0.7 3.3 10.4 -0.1 3.2 2.3 -1.2 1.1 -1.7 2.3 0.2
Leg predicted mass (left) 1.8 9.6 23.8 -0.7 -4.9 -4.7 -1.5 -2.9 0.4 -3.8 -2.3
Trunk fat mass 0.1 0.2 0.6 -0.7 0.8 0.4 0.1 0.6 0.4 0.1 -0.1
Waist circumference 0.2 0.7 2.2 -0.1 1.0 1.1 -0.9 -0.2 0.7 1.5 0.0
Number of incorrect matches in round 0.5 0.8 2.0 -0.4 1.2 -0.7 -0.8 -1.4 -0.6 1.0 -0.5
Past tobacco smoking 0.7 1.3 7.5 2.7 -0.3 0.3 0.2 1.1 0.2 1.1 0.1
Alcohol usually taken with meals 1.1 1.8 4.3 0.5 1.9 0.7 -2.1 -1.2 -0.0 2.0 -1.0
Nervous feelings 0.9 1.7 8.4 2.9 -1.2 -0.7 -0.1 0.7 1.3 1.0 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 5.7 0.3 0.8 -0.4 -0.9 -0.6 2.4 0.5 -0.8
Hearing difficulty/problems with background noise 0.8 1.3 1.8 -1.3 1.4 -0.9 -0.9 0.5 1.4 -1.2 -1.2
Hair/balding pattern: Pattern 2 4.8 6.1 14.7 -2.3 -3.3 -3.0 -0.8 -2.0 0.3 -3.8 -2.0
Had menopause 0.6 0.8 1.8 0.2 1.0 0.5 -1.4 1.2 -0.8 0.8 0.2
Had other major operations 0.5 0.6 2.0 -0.3 1.4 0.7 -0.3 1.0 0.1 0.8 -0.6
Forced vital capacity (FVC) 1.8 6.9 19.6 -1.0 -4.4 -2.9 0.1 -2.0 -3.6 -2.8 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.0 2.9 1.4 -1.7 -0.6 1.3 -0.1 -0.6 -0.1 0.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.6 -0.2 0.9 0.5 0.6 -0.3 0.7 0.3 1.3
Qualifications: None of the above 0.3 0.5 1.4 -1.2 0.7 -0.4 -0.8 -0.4 1.1 -0.1 -0.5
Financial difficulties in last 2 years 0.2 0.3 0.7 0.4 -0.8 -0.5 0.7 -0.3 0.5 -0.4 0.4
Mouth/teeth dental problems 1.1 1.7 4.5 0.3 1.1 -0.8 -1.6 0.4 2.1 -0.5 -1.9
Heart attack 2.2 2.8 6.1 -0.3 2.2 2.5 1.7 2.3 -0.0 0.7 1.5
Allergy 0.2 0.5 1.3 -0.6 -0.6 -0.4 -1.0 -0.2 -1.1 -0.5 -0.6
Pain all over the body in last month 0.4 0.4 1.8 0.2 -1.3 -0.4 -0.3 -0.7 0.1 -0.9 0.0
Diabetes (self-reported) 0.9 1.4 3.1 0.3 -0.7 -1.3 -1.5 -1.8 -1.4 0.2 -1.1
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.6 -0.8 -0.2 -1.4 -1.1 -1.6 -0.1 -0.9 -1.5
Medication: Ramipril 0.4 0.5 2.0 0.7 0.5 0.7 -0.4 1.4 0.2 0.8 -0.4
Medication: Simvastatin 1.3 1.9 4.5 -0.9 1.7 -0.2 -1.1 -1.4 -2.1 1.2 -1.4
Fluid intelligence score 2.0 4.2 11.2 -0.2 2.9 2.5 1.0 3.4 -0.0 1.9 1.5
Illnesses of siblings 2.1 2.9 6.7 -0.8 -2.6 -2.2 0.3 -1.7 -0.9 -2.5 -0.8
Neuroticism score 0.3 0.7 2.5 -0.4 -0.3 -1.1 -0.9 -0.2 1.6 -0.5 -0.7
Weight 0.3 1.6 3.5 -0.2 -1.4 -1.9 -1.4 -1.5 0.4 -0.9 -1.2
Impedance of arm (right) 0.4 2.1 6.2 -1.4 0.9 1.4 0.9 2.5 -2.2 -0.3 0.3
Arm fat percentage (right) 0.7 2.9 7.4 -0.9 2.7 2.4 1.4 1.9 0.8 1.4 1.0
Trunk fat-free mass 2.5 14.3 30.8 0.5 -5.5 -5.5 -3.7 -4.6 -0.0 -2.9 -3.2
Hip circumference 0.5 2.3 4.7 -1.7 -0.3 -1.5 -1.8 -2.2 0.3 -1.4 -1.8
Time employed in main current job 1.3 1.5 3.5 -1.2 -0.6 -0.9 -1.6 -1.9 -1.5 -0.8 -0.8
Alcohol intake versus 10 years previously 0.4 0.6 1.4 -1.2 1.0 0.2 -0.3 0.8 -0.1 -0.7 -1.0
Father’s age at death 0.5 0.7 2.5 -0.0 -0.9 -1.6 -0.1 -0.9 -0.1 -0.8 -0.8
Worrier / anxious feelings 0.7 1.4 4.8 0.6 0.1 -1.4 -1.8 -0.4 1.0 0.1 -2.2
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 3.8 1.5 -1.9 -1.7 1.2 -1.3 1.7 -0.7 0.8
Falls in the last year 0.2 0.3 1.1 0.2 0.5 -0.2 -0.5 0.7 1.0 -0.1 0.3
Hair/balding pattern: Pattern 3 4.1 6.1 14.4 1.9 2.6 3.5 1.2 2.1 1.3 3.8 2.0
Number of live births 1.8 2.5 5.0 2.2 -1.8 0.5 1.6 1.5 1.8 -0.1 1.9
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 10.8 -1.0 -3.3 -1.8 1.1 -1.1 -2.5 -2.3 -0.4
Pulse rate 0.3 0.4 1.1 0.7 -0.8 -0.7 1.0 0.2 0.3 -0.2 0.7
Happiness 0.3 0.4 0.9 -0.1 0.1 0.9 0.6 0.9 -0.6 0.2 0.9
Noisy workplace 0.6 0.8 2.0 -1.4 1.1 -0.4 -0.3 -1.4 -0.4 -0.6 -0.3
Qualifications: A levels/AS levels or equivalent 0.3 0.7 3.4 1.8 -0.2 0.3 -0.6 0.2 0.9 1.0 0.4
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 4.6 1.0 0.7 1.6 1.1 0.7 0.0 2.1 1.4
Mouth/teeth dental problems: Dentures 1.7 2.9 5.2 0.8 1.0 2.0 2.1 1.4 -1.3 2.0 2.3
Asthma 0.8 1.5 3.5 1.9 0.5 1.2 1.2 0.7 0.6 1.5 1.6
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.9 -0.8 -1.3 0.0 1.4 0.5 1.1 -1.6 1.7
Medication: Cholesterol lowering 1.1 1.8 4.3 -1.5 1.8 0.5 -1.2 -0.9 -2.1 0.3 -1.3
Depression (self-reported) 1.2 1.4 3.6 -1.9 -1.5 -0.8 0.9 -0.8 -0.7 -1.7 0.5
Medication: Lansoprazole 1.9 2.2 6.0 1.4 0.7 1.8 1.1 1.4 -0.4 2.5 1.6
Prospective memory result 2.2 2.7 8.8 -0.4 -2.0 -2.6 -0.6 -3.0 -0.4 -1.0 -0.7
Lung cancer (father) 0.4 0.5 1.1 0.8 0.1 0.8 -0.4 -0.2 0.8 1.0 0.6
Illnesses of mother 4.0 4.9 15.0 -1.0 -3.9 -3.0 0.3 -0.7 0.8 -3.2 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.7 17.4 -1.0 -4.2 -2.8 0.1 -2.1 -2.6 -2.7 -0.7
Pulse wave Arterial Stiffness index 0.1 0.1 0.4 -0.0 -0.6 0.5 -0.4 0.3 -0.4 -0.2 0.4
Impedance of arm (left) 0.5 2.3 7.7 -1.6 1.1 1.3 0.8 2.1 -2.8 -0.2 0.3
Arm fat mass (right) 0.1 0.4 1.2 -0.5 0.9 0.6 0.4 0.4 1.1 0.5 0.3
Trunk predicted mass 2.5 14.1 30.2 0.5 -5.4 -5.5 -3.7 -4.6 0.0 -2.9 -3.2
Standing height 3.0 29.5 60.5 -0.7 -7.5 -7.8 -5.5 -5.1 -3.4 -4.9 -5.2
Length of working week for main job 2.6 2.9 8.5 -1.5 -2.9 -1.5 -0.7 -1.2 0.8 -2.7 -0.4
Exposure to tobacco smoke at home 0.5 0.6 2.6 -1.6 0.1 0.3 0.6 0.9 -0.3 -0.6 0.5
Breastfed as a baby 0.3 0.4 1.5 -0.2 -0.0 -0.9 1.2 0.8 -0.2 -0.7 -0.1
Tense / ‘highly strung’ 0.8 1.4 4.3 0.6 -1.2 -1.6 -2.1 -0.3 1.4 -0.4 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 5.9 1.8 0.7 0.7 0.7 1.5 2.4 1.1 1.5
Hair/balding pattern: Pattern 4 0.3 0.8 2.0 -0.7 0.5 -1.0 -1.0 -0.7 -1.2 0.2 -1.4
Birth weight of first child 2.1 3.8 11.4 -1.5 -3.4 -2.0 -0.2 -1.4 0.3 -3.1 -1.0
Peak expiratory flow (PEF) 0.1 0.2 0.8 0.2 0.2 -0.1 0.7 -0.9 -0.6 0.3 0.2
Pulse wave reflection index 0.1 0.1 0.2 -0.4 0.3 0.4 0.0 0.5 0.3 -0.1 -0.2
Ever highly irritable/argumentative for 2 days 0.8 1.0 3.3 -0.7 -1.8 -1.4 -0.3 -0.5 0.6 -1.2 -0.3
Loud music exposure frequency 0.3 0.3 1.5 0.7 0.3 0.3 1.2 0.2 0.0 0.2 0.4
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.9 2.0 -1.4 -0.1 0.8 -0.3 1.3 0.4 0.7
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.7 0.5 -1.6 -0.6 0.6 -0.3 0.4 -0.7 0.7
Blood clot in the leg (DVT) 0.3 0.4 0.9 -0.3 0.6 -0.9 0.3 0.2 1.0 -1.0 0.0
Medication: Paracetamol 1.9 3.2 11.9 1.9 0.7 1.3 -0.3 1.5 3.4 1.9 1.3
Headache pain in last month 0.8 1.3 4.2 0.8 -2.0 -0.8 0.9 -1.2 -0.3 -1.4 1.1
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 4.1 0.2 -2.0 -1.6 0.4 -0.9 0.7 -1.3 0.0
Glaucoma (self-reported) 1.1 1.3 3.5 -0.9 1.4 -0.2 -1.9 -0.4 -0.4 -0.1 -1.8
Gout (self-reported) 3.2 4.3 7.8 -2.8 -1.6 -1.5 -2.0 -2.1 -1.9 -2.6 -1.9
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.7 0.8 -0.4 0.4 0.3 -0.0 0.2 0.5 0.8
Medication: Amlodipine 1.0 1.4 4.1 0.1 1.9 0.7 -1.0 0.5 -0.9 2.0 -0.8
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.6 1.6 0.9 0.6 0.8 0.3 0.1 1.4 1.1
Birth weight 1.3 2.7 6.8 -1.7 -2.4 -0.2 2.1 1.2 -0.3 -2.6 0.7
Chronic bronchitis/emphysema (mother) 1.4 1.7 5.7 -0.0 2.4 1.2 -0.5 0.1 1.3 2.0 0.7
High blood pressure (siblings) 0.9 1.3 2.8 1.1 1.3 1.4 -0.1 1.1 0.5 1.7 1.1
Forced vital capacity (FVC), Best measure 2.7 9.8 30.5 -0.5 -5.5 -4.0 -0.7 -2.7 -3.2 -3.3 -1.4
Body fat percentage 0.8 3.1 9.9 -1.0 3.1 2.5 0.9 1.9 0.5 1.5 0.8
Leg fat percentage (right) 1.5 5.4 18.9 -0.6 4.3 3.4 0.1 2.0 1.1 2.6 0.8
Arm fat-free mass (right) 1.8 9.4 20.3 0.4 -4.2 -4.5 -2.9 -4.0 0.6 -2.5 -2.5
Exposure to tobacco smoke outside home 1.3 1.7 4.3 -2.1 0.0 1.1 2.1 0.4 -1.0 -0.1 1.6
Comparative body size at age 10 2.1 5.7 15.7 0.3 3.1 4.0 2.4 1.2 -0.1 2.2 2.8
Number of full brothers 0.5 0.7 2.2 -0.8 -0.7 -0.1 1.2 -0.2 1.5 -0.2 0.7
Worry too long after embarrassment 0.5 0.8 1.5 1.1 -1.0 -1.2 0.2 0.6 1.2 -0.9 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 2.2 0.4 -1.5 -0.2 0.5 -0.0 0.3 -0.3 0.8
Wheeze or whistling in the chest in last year 0.4 0.8 2.8 -0.4 0.3 0.3 1.0 -0.6 1.7 -0.4 1.2
Number of children fathered 1.1 1.3 4.0 2.0 -0.5 0.9 0.7 0.7 -1.1 1.5 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 3.4 0.6 -0.3 -0.8 -1.8 -0.1 -0.1 0.1 -1.5
Age at first live birth 0.5 0.9 3.6 0.2 -0.7 -1.0 -0.5 -0.4 -0.7 -1.0 -1.9
Pulse wave peak to peak time 0.2 0.2 0.9 0.0 0.1 -0.9 0.2 -0.5 0.4 -0.2 -0.6
Health satisfaction 0.3 0.4 1.1 -0.6 -1.0 -0.5 0.2 -0.7 -0.8 -0.8 -0.0
Shortness of breath walking on level ground 1.1 1.3 2.5 1.4 0.6 1.2 1.3 0.1 -0.8 1.6 1.3
Qualifications: College or University degree 0.2 0.6 1.6 0.8 0.8 0.5 -0.0 0.8 -1.1 1.3 -0.1
Eye problems/disorders: None of the above 0.8 0.9 2.0 0.4 0.5 0.8 0.9 -0.4 1.3 1.4 1.1
Mouth/teeth dental problems: Loose teeth 0.6 0.8 2.3 -0.3 -0.2 1.0 1.4 -0.1 -0.3 0.7 1.5
Emphysema/chronic bronchitis 0.9 1.0 5.0 2.2 -0.1 0.1 -0.2 -0.5 0.7 1.5 -0.3
Medication for pain relief, constipation, heartburn 0.6 1.1 6.9 -0.1 0.0 -0.5 -0.1 -0.3 -2.6 -0.1 -1.1
Neck or shoulder pain in last month 0.8 1.2 3.2 -1.3 -0.8 -1.0 -0.3 -0.4 1.8 -1.3 -1.0
Medication: Blood pressure 1.6 2.8 6.4 1.2 2.5 2.3 -0.3 1.6 0.3 2.5 0.7
Angina (self-reported) 1.5 1.9 8.0 -1.5 2.8 1.8 1.0 0.5 -0.2 0.7 0.5
Migraine (self-reported) 0.3 0.4 0.9 0.0 1.0 0.9 0.2 0.7 -0.5 0.3 0.7
Medication: Ibuprofen 0.9 1.1 3.1 -1.2 -1.8 -0.7 0.3 -0.2 0.7 -1.7 0.6
Medication: Allopurinol 3.3 4.3 7.3 -2.3 -1.8 -2.0 -2.1 -2.3 -1.0 -2.7 -2.1
Medication: Omeprazole 0.8 0.9 2.7 0.5 -0.7 0.0 1.6 0.4 1.5 -0.5 1.2
Medication: Seretide 50 evohaler 0.6 0.6 1.4 0.9 0.6 0.9 0.3 1.1 -0.3 1.2 0.6
Mean time to correctly identify matches 0.2 0.4 0.8 -0.6 -0.8 0.4 0.1 0.8 0.1 -0.9 0.9
Heart disease (mother) 1.1 1.3 2.1 1.1 -0.1 1.3 0.4 1.4 -1.3 1.4 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.8 3.4 12.1 0.8 3.5 1.7 1.0 1.5 -0.4 2.7 0.7
Whole body fat mass 0.1 0.4 1.2 -1.0 1.1 0.7 0.0 0.4 0.6 0.3 -0.1
Leg fat mass (right) 0.2 0.9 3.1 -0.6 1.8 1.2 -0.1 0.7 1.0 0.8 -0.0
Arm predicted mass (right) 1.8 9.1 20.2 0.4 -4.4 -4.5 -2.7 -3.7 0.6 -2.4 -2.3
Pulse rate, automated reading 0.6 1.9 5.5 2.2 -2.4 -1.9 0.7 0.0 1.0 -0.3 -0.3
Alcohol intake frequency. 1.0 2.3 9.2 1.1 2.1 1.0 0.4 0.7 3.0 1.4 0.6
Comparative height size at age 10 1.5 8.3 28.2 -0.2 -5.3 -4.0 -2.5 -2.3 -1.8 -2.3 -1.5
Number of full sisters 0.8 1.0 2.5 0.2 -1.6 -0.8 0.5 0.7 1.3 -1.5 0.0
Suffer from ‘nerves’ 0.8 1.3 6.3 0.8 -2.5 -1.2 -0.6 -0.2 1.1 -0.7 0.2
Overall health rating 0.2 0.5 2.1 -0.3 -0.6 -0.7 0.0 -1.0 1.5 -0.2 0.0
Chest pain or discomfort 0.2 0.3 0.7 0.8 -0.8 -0.1 -0.4 -0.2 -0.1 0.3 0.8
Had major operations 1.2 1.4 5.2 0.8 -0.2 1.2 0.7 0.4 1.2 1.3 2.3
Age at last live birth 0.1 0.1 0.4 0.1 -0.6 0.0 0.3 -0.3 -0.1 -0.3 -0.3
Family relationship satisfaction 0.4 0.5 1.6 0.2 -1.1 -0.5 -1.3 0.5 0.1 -0.6 -0.0
Leg pain on walking 0.5 0.6 1.6 -0.2 0.4 0.8 0.5 -0.3 -1.3 0.5 1.2
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.3 -1.1 1.5 0.8 -0.1 -0.1 -0.8 0.2 0.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.0 -0.4 -0.6 0.5 0.8 0.3 -1.4 -0.7 1.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.4 0.2 -0.6 -0.4 -0.4 0.2 0.3 -0.5 -1.2
Medication: Aspirin 1.0 1.3 6.2 -0.5 2.5 1.5 -0.1 0.1 0.6 1.2 0.2
Supplements: Vitamin C 1.3 1.5 5.2 0.3 -2.3 -1.5 -1.1 -1.8 0.5 -0.1 -0.4
Knee pain experienced in last month 0.4 0.6 1.5 -0.3 -0.5 -0.7 0.9 0.8 1.2 -0.6 0.7
Hypertension (Self-reported) 1.3 3.6 11.3 0.5 3.4 2.6 -0.9 1.6 -0.1 2.6 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.0 1.1 -0.8 -0.4 -0.0 0.6 1.4 0.6 -0.3
Illnesses of father: Heart disease 0.6 0.8 1.7 -1.1 1.3 0.8 -1.1 1.1 -0.0 0.3 -0.3
Illnesses of siblings: Diabetes 0.8 0.9 2.5 1.1 1.0 0.7 -0.3 1.2 0.8 1.6 0.2
Smoking status: Previous 0.4 0.6 2.2 -1.5 -0.1 -0.2 -0.9 -1.3 -0.1 -0.6 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.1 9.0 -0.1 -3.0 -2.8 -1.3 -2.3 -1.3 -2.1 -1.9
Whole body fat-free mass 2.2 12.6 28.4 0.0 -5.3 -5.3 -2.9 -4.1 0.2 -3.3 -2.9
Leg fat-free mass (right) 2.0 10.7 25.9 -0.7 -5.1 -5.0 -1.8 -3.4 0.3 -3.8 -2.3
Arm fat percentage (left) 0.7 2.7 6.8 -1.0 2.6 2.2 1.4 1.9 0.6 1.2 1.0
Average weekly red wine intake 0.3 0.5 1.8 -0.7 0.5 0.3 -0.1 -1.3 -1.1 0.1 -0.3
Handedness (chirality/laterality): Left-handed 1.6 1.9 5.6 2.4 -0.4 0.4 1.1 1.0 0.7 2.0 1.5
Mood swings 0.5 1.0 3.1 -1.8 0.2 -1.2 -0.5 -0.1 0.3 -1.2 -1.2
Loneliness, isolation 0.5 0.7 1.8 -0.7 -0.1 -0.8 -1.4 -0.8 0.9 -0.7 -0.7
Long-standing illness, disability or infirmity 0.2 0.3 0.7 -0.4 0.5 0.8 -0.6 -0.3 0.4 0.2 0.7
Ever had bowel cancer screening 1.4 1.7 5.5 -0.6 0.7 -1.3 -1.9 -1.1 -0.9 -0.4 -2.3
Diabetes diagnosed by doctor 1.2 2.0 4.7 -0.8 -0.8 -1.4 -1.5 -1.8 -2.2 -0.5 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 3.2 1.8 -0.2 0.2 1.1 0.1 1.1 1.3 0.7
Friendships satisfaction 0.3 0.3 1.5 -0.8 -0.1 0.4 -1.2 0.2 -0.0 0.4 0.3
Qualifications: nursing, teaching 1.2 1.8 5.0 2.2 0.2 1.0 1.4 1.7 0.5 1.0 1.5
Commuting to job workplace: Walk 0.7 0.8 1.6 -0.8 0.0 -1.3 -1.3 -0.1 1.3 -0.6 -0.8
Eye problems/disorders: Cataract 0.8 0.9 2.2 -1.3 0.6 0.6 0.6 1.5 -1.5 -0.5 0.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.2 -1.1 -0.0 0.1 -0.1 -0.7 -1.1 0.2 0.1
Medication for cholesterol 0.4 0.7 3.5 1.9 -0.5 0.2 -0.1 0.3 1.0 0.0 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 5.8 -0.9 -1.1 -1.3 -0.1 0.4 0.2 -2.4 -0.2
Back pain experienced in last month 1.1 1.6 4.3 -1.8 -0.8 -1.4 -0.1 -1.5 -0.1 -2.1 -0.4
Mineral and other dietary supplements 0.9 1.2 2.5 1.4 -0.5 1.0 1.6 1.5 0.2 1.1 0.3
Breast cancer (self-reported) 1.3 1.5 3.6 -0.4 -1.8 -1.5 -0.3 -1.7 -0.0 -1.9 -0.3
Asthma (self-reported) 0.6 1.2 3.8 1.9 0.3 0.8 0.7 0.1 0.7 1.5 1.3
Osteoporosis (self-reported) 0.5 0.6 1.7 -1.0 0.3 0.5 0.8 0.4 -0.7 -0.7 1.3
Osteoarthritis (self-reported) 1.7 2.2 6.5 1.6 1.3 1.9 -0.2 0.3 0.9 2.6 1.4
Medication: Aspirin 2.6 3.4 15.3 -0.5 3.9 2.5 0.2 0.6 0.5 2.1 0.6
Medication: Gliclazide 0.9 1.1 3.6 0.2 -0.7 -0.9 -0.6 -1.2 -1.9 0.0 -1.2
Illnesses of father: None of the above (group 1) 2.4 3.0 6.8 -1.1 -2.5 -2.3 -0.2 -1.7 -0.5 -2.6 -0.9
Smoking status: Current 0.9 1.4 4.0 -2.0 -1.2 -1.4 0.9 -1.0 0.4 -1.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 6.7 0.4 0.1 0.4 2.6 0.4 -2.1 -0.1 1.7
Whole body water mass 2.2 12.3 28.5 0.2 -5.3 -5.3 -2.8 -4.1 0.2 -3.2 -2.7
Leg predicted mass (right) 2.0 10.8 26.1 -0.7 -5.1 -5.0 -1.8 -3.5 0.4 -3.8 -2.4
Arm fat mass (left) 0.1 0.3 0.8 -0.8 0.9 0.5 0.2 0.2 0.7 0.3 0.1
Number of self-reported non-cancer illnesses 0.7 1.2 3.9 0.9 1.4 1.0 -0.8 -0.1 1.1 2.0 0.3
Average weekly champagne plus white wine intake 1.3 1.8 6.7 -0.2 -0.1 -1.1 -2.6 -2.0 0.1 0.9 -1.3
Miserableness 0.4 0.7 2.1 -1.0 1.2 0.7 0.1 -0.1 1.5 0.7 0.5
Guilty feelings 0.5 0.8 2.3 0.0 1.5 0.8 -0.4 -0.5 -0.0 1.5 0.9
Wears glasses or contact lenses 0.7 0.8 1.8 -0.6 1.2 1.3 0.5 1.4 0.6 0.7 0.7
Ever taken oral contraceptive pill 3.6 4.0 8.0 1.1 2.3 2.6 1.9 0.4 -1.1 2.8 2.4
Hearing aid user 1.6 1.8 4.0 0.2 1.9 1.5 1.0 2.0 1.6 0.8 0.6
Mother’s age at death 0.9 1.1 2.5 -0.4 1.6 1.4 -0.1 1.5 -1.4 0.4 0.5
Financial situation satisfaction 0.7 0.9 3.0 0.1 -1.7 0.7 1.4 -0.2 -0.4 -0.1 1.4
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.4 0.1 1.2 0.7 0.3 0.0 0.6 1.1 1.2
Commuting to job workplace: Public transport 1.4 1.7 4.7 1.5 1.4 1.3 0.4 0.8 2.2 1.3 0.7
Eye problems/disorders: Glaucoma 2.9 3.4 13.5 -0.6 0.9 -1.1 -3.7 -1.6 0.6 -0.6 -2.8
Medication: Blood pressure 0.2 0.4 1.3 0.0 1.0 0.3 -0.7 0.2 -0.3 1.1 -0.5
Pain type(s) experienced in last month: Hip pain 0.8 1.0 3.1 -0.2 0.6 1.5 1.4 0.2 -0.1 0.6 1.8
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.0 -0.8 -0.7 -1.2 -1.4 -1.3 -0.5 -1.0 -0.8
High cholesterol (Self-reported) 0.8 1.4 4.8 -1.6 -0.0 -0.2 -0.8 -1.3 -2.2 -0.2 -1.1
Medication: Bendroflumethiazide 0.8 1.2 5.1 0.8 0.9 0.0 -2.3 0.3 -0.6 1.3 -1.1
Medication: Paracetamol 1.2 1.8 8.6 1.0 0.7 1.0 -0.7 0.8 2.9 1.3 0.8
Medication: Lisinopril 1.2 1.5 5.8 0.8 1.9 0.5 0.6 2.4 -0.0 1.1 -0.4
Medication: Atorvastatin 0.3 0.4 1.3 -1.1 -0.2 -0.5 -0.5 -0.1 -0.0 -0.9 -0.9
Illnesses of father: High blood pressure 6.7 8.3 13.8 0.9 3.7 3.5 3.0 3.4 -0.2 3.3 2.9
Alcohol drinker status: Never 0.7 0.9 2.1 0.2 -1.4 -1.3 -0.9 -0.3 0.6 -0.8 -1.2
Ever smoked 0.5 0.9 5.1 -2.2 0.1 -0.4 0.1 -1.1 0.1 -1.0 -0.0
Basal metabolic rate 1.7 9.4 21.2 -0.1 -4.5 -4.6 -2.5 -3.6 0.3 -2.8 -2.5
Leg fat percentage (left) 1.3 4.8 17.3 -0.6 4.2 3.1 -0.0 1.5 1.1 2.7 0.8
Arm fat-free mass (left) 1.6 8.4 17.9 0.6 -4.0 -4.2 -2.8 -3.8 0.7 -2.1 -2.2
Number of operations (self-reported) 1.0 1.5 3.8 1.0 0.7 1.9 -0.0 0.8 1.2 1.9 1.1
Average weekly beer plus cider intake 1.0 1.5 4.2 0.0 -1.9 -1.5 0.8 -0.8 -0.3 -2.0 0.5
Irritability 2.3 3.9 11.8 -3.4 -0.8 -2.0 -1.1 -1.2 0.3 -2.9 -2.1
Risk taking 1.8 2.7 8.2 -1.7 -2.9 -1.1 1.6 -0.4 -1.7 -1.8 0.6
Ever had prostate specific antigen (PSA) test 2.3 2.7 9.8 1.9 1.8 1.2 -1.0 0.3 1.5 3.1 -0.0
Fractured/broken bones in last 5 years 0.8 1.0 3.1 1.8 0.0 -0.3 -0.0 1.5 1.6 0.2 -0.0
Age started oral contraceptive pill 2.5 3.2 8.4 2.3 2.9 1.8 -0.9 1.6 0.2 2.3 -0.4
Diastolic blood pressure, automated reading 0.9 2.8 8.2 1.6 2.9 1.7 0.8 1.6 1.0 1.7 1.1
Ever depressed for a whole week 3.1 3.8 8.1 1.7 2.8 1.8 1.2 1.1 1.0 2.7 2.2
Unable to work because of sickness or disability 0.5 0.7 3.1 -0.1 0.1 0.6 0.9 0.2 1.8 -0.3 1.1
Commuting to job workplace: Cycle 1.5 1.8 5.4 -0.8 1.0 -1.1 -2.3 -1.7 0.0 -0.2 -1.8
Myopia 0.6 0.9 2.3 0.5 1.5 0.9 0.8 1.5 -0.6 0.6 0.5
Vascular/heart problems diagnosed by doctor 1.4 4.0 11.1 -0.6 -3.3 -3.0 0.5 -1.8 -0.1 -2.7 -0.7
Cholesterol lowering medication 0.4 0.6 1.8 -0.9 0.7 0.5 0.1 -0.2 -1.3 0.9 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 4.1 0.5 -1.1 -0.2 1.4 0.6 2.0 -0.6 1.0
Pain experienced in last month 1.5 2.5 11.5 -0.1 3.4 1.5 -1.4 0.2 -0.4 2.0 -0.7
Supplements: Calcium 1.3 1.4 4.4 -1.3 -2.1 -0.6 -1.1 -1.2 -0.4 -1.3 -0.4
Basal cell carcinoma (self-reported) 0.6 0.8 2.6 -0.6 -1.6 -0.9 -0.5 -0.5 -0.9 -0.9 -0.3
Heart attack/myocardial infarction (self-reported) 2.3 3.0 6.9 -0.2 2.2 2.6 1.6 2.3 -0.2 0.9 1.7
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.1 -0.2 0.9 -0.8 0.1 0.5 1.1 -0.7 0.1
Heart disease (siblings) 1.1 1.4 2.9 -0.4 1.0 1.6 1.0 0.9 0.4 1.4 1.7
Alcohol drinker status: Previous 0.8 0.9 1.8 -1.2 1.1 0.8 0.8 -0.3 1.3 0.7 1.1
Pack years of smoking 1.2 1.7 5.2 -0.4 -0.7 1.3 2.3 1.9 0.8 -0.3 1.3
Impedance of whole body 0.5 2.8 6.6 -1.2 2.3 2.0 0.2 2.0 -2.6 0.8 0.4
Leg fat mass (left) 0.2 0.7 2.6 -0.5 1.6 1.0 -0.1 0.3 1.0 0.9 0.1
Arm predicted mass (left) 1.3 6.8 14.3 1.1 -3.8 -3.8 -2.4 -3.4 1.1 -1.6 -1.8