Hub : Genes

FAM171A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0930 0.0260 1.8e-06 0.034 0.043 0.031 0.040 0.046 4.7e-05 5.5e-06 9.5e-05 9.7e-06 2.7e-06
2 GTEx Muscle Skeletal 0.1975 0.0499 1.0e-06 0.038 NA 0.022 NA 0.025 1.1e-04 NA 3.0e-03 NA 1.6e-03
3 GTEx Nerve Tibial 0.2845 0.0585 2.3e-08 0.096 NA 0.205 NA 0.229 2.7e-07 NA 1.6e-14 NA 3.2e-16
4 GTEx Pituitary 0.2890 0.0970 7.9e-03 0.264 NA 0.167 NA 0.303 2.6e-07 NA 5.6e-05 NA 2.4e-08
5 GTEx Stomach 0.1520 0.0560 2.6e-03 0.080 NA 0.078 NA 0.070 1.2e-04 NA 1.4e-04 NA 2.9e-04
6 NTR Blood 0.0350 0.0136 3.3e-03 0.007 0.006 0.003 0.008 0.001 2.3e-03 3.4e-03 2.8e-02 8.6e-04 1.0e-01
7 ROSMAP Brain Pre-frontal Cortex 0.0958 0.0254 3.4e-07 0.046 0.055 0.130 0.090 0.111 1.1e-06 1.2e-07 2.2e-16 1.3e-11 4.2e-14
8 YFS Blood 0.2541 0.0307 0.0e+00 0.093 0.169 0.193 0.196 0.181 1.2e-28 5.6e-53 5.3e-61 4.0e-62 4.9e-57
9 TCGA Breast Invasive Carcinoma 0.0204 0.0103 4.1e-03 0.002 0.008 0.014 NA 0.005 1.1e-01 7.0e-03 5.2e-04 NA 2.8e-02
10 TCGA Colon Adenocarcinoma 0.0680 0.0340 6.4e-03 0.004 0.022 0.007 NA 0.000 1.8e-01 1.9e-02 1.2e-01 NA 3.3e-01
11 TCGA Prostate Adenocarcinoma 0.0341 0.0167 6.1e-03 0.013 0.015 0.016 NA 0.013 1.5e-02 8.5e-03 7.7e-03 NA 1.5e-02
12 TCGA Thyroid Carcinoma 0.0400 0.0190 4.1e-03 0.052 0.030 0.033 NA 0.040 7.9e-06 5.5e-04 3.3e-04 NA 8.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 1.1 1.8 4.9 1.3 1.6 1.2 -1.7 0.2 -0.2 2.2 1.1 1.2 0.6 1.6 1.5
Bipolar Disorder or Schizophrenia 2.0 4.8 11.8 2.5 2.6 1.0 -0.9 0.7 1.0 2.8 1.8 3.0 1.9 3.4 2.5
Depressed Affect (Nagel 2018) 1.1 2.3 5.4 -1.6 -0.1 -1.7 -1.5 -0.8 2.2 -1.6 1.2 -0.9 0.4 -2.1 -2.3
Depression (Nagel 2018) 1.0 1.4 4.9 -0.6 0.7 -1.7 -2.2 -0.1 -0.8 -1.1 0.9 -0.6 0.3 -1.7 -1.5
Intelligence (Savage-Jansen 2018) 0.6 1.8 5.9 -1.4 -1.9 -0.2 -0.5 -2.4 -1.6 0.3 0.2 -1.2 -2.3 -0.6 0.2
Neuroticism (Nagel 2018) 0.7 1.7 4.7 -1.0 0.3 -1.4 -1.4 -0.5 1.4 -2.0 0.0 -0.4 1.1 -1.9 -2.2
Schizophrenia (2018) 1.7 3.6 9.7 2.1 2.1 0.3 0.2 0.6 1.4 1.9 1.4 2.9 2.0 3.1 2.0
Schizophrenia vs Biploar Disorder 0.3 0.4 2.3 0.5 -0.1 -1.1 1.0 -0.3 0.2 -0.1 0.3 0.5 0.3 1.5 -0.1
Worry (Nagel 2018) 0.4 0.8 1.9 -0.1 0.7 -0.8 -1.2 -0.5 1.2 -0.9 0.0 0.8 1.0 -0.8 -1.4
Alzheimer’s Disease (in mother) 1.0 1.2 4.0 0.8 1.3 1.5 -0.4 1.0 -1.5 1.0 -0.6 0.7 2.0 -0.7 0.4
Alzheimer’s Disease (in father) 1.5 1.6 3.2 0.6 1.0 0.9 -1.5 -0.1 1.4 1.8 1.7 1.4 -0.1 1.2 1.8
Alzheimer’s Disease (including proxy) 0.7 1.0 2.7 0.5 1.1 1.0 -1.3 -0.4 -0.5 1.7 0.5 1.0 1.2 -0.2 1.2
Crohns Disease (2017) 2.9 6.4 13.8 -3.3 -3.3 -0.9 -0.1 -1.8 -1.3 -3.7 0.8 -3.6 -3.7 -2.4 -1.5
Irritable Bowel Disease (IBD) 1.0 2.4 6.6 -1.4 -2.3 0.5 0.5 -0.6 -1.6 -2.6 -0.8 -2.2 -2.4 -0.3 0.2
Ulcerative Colitis (UC) 0.5 1.0 2.5 0.4 -0.8 1.5 1.1 0.2 -0.7 -0.8 -1.1 -0.2 -0.8 1.6 1.4
Major Depression (MDD) 0.6 0.8 6.6 -0.4 0.8 -0.0 -2.6 -0.0 0.7 0.6 0.3 0.4 0.7 -0.7 0.1
Reaction Time 4.7 8.9 20.2 4.5 4.1 3.1 0.2 3.7 0.5 3.2 -0.9 3.0 2.9 3.3 2.6
Verbal and Numeric Reasoning (VNR) 0.8 1.8 6.0 -1.1 -1.6 0.5 -2.0 -1.8 -1.5 0.5 -0.8 -0.8 -2.5 -0.4 0.5
Breast Cancer 0.5 1.2 5.1 -0.0 -1.1 -1.3 2.3 -0.8 0.3 0.9 1.8 0.4 -0.9 0.0 -0.1
Ovarian Cancer 0.8 1.0 3.3 -0.4 1.4 -0.8 -1.2 -0.3 0.6 0.0 -0.1 0.4 1.7 -1.0 -1.8
Prostate Cancer 1.5 2.1 5.2 -1.6 -1.8 -0.9 0.2 -2.2 -0.2 -0.5 0.6 -1.0 -1.6 -2.3 -1.9
Age at First Birth 1.1 1.7 3.4 1.7 0.7 1.7 1.0 1.4 1.0 0.7 -0.7 1.7 0.1 1.5 1.8
Bipolar Disorder (2011) 1.2 1.2 3.7 0.9 0.9 1.9 -1.5 0.3 0.1 0.7 1.2 1.4 0.2 1.0 1.2
Body Mass Index (BMI) (2010) 0.7 0.9 4.6 -1.3 -0.4 -0.7 -2.1 -0.9 -1.3 0.4 -0.5 -0.8 -0.8 -0.2 0.1
Coronary Artery Disease (CAD) 1.4 1.7 4.8 -2.2 -1.3 -1.0 0.6 -0.7 -0.6 -1.8 -0.4 -1.8 -1.2 -1.4 -1.5
Crohns Disease (2012) 3.6 5.8 15.2 -3.3 -2.6 -1.3 -0.8 -1.6 -2.6 -3.9 -0.3 -3.5 -2.7 -1.8 -1.7
Mean Putamen Volume 0.8 0.9 3.2 -0.5 -1.0 -1.2 0.4 -0.9 -0.4 -0.4 1.7 -0.9 -1.8 0.0 0.1
Fasting Glucose 0.4 0.5 1.4 0.6 0.1 -0.1 0.8 -0.0 -0.4 1.2 1.0 0.7 0.3 1.1 0.8
HbA1C 0.3 0.4 1.5 0.1 -0.8 0.4 0.7 -0.3 -0.1 -0.3 -0.3 -0.6 -1.2 0.3 1.1
HDL Cholesterol 1.0 1.7 4.9 1.1 -0.7 2.0 1.0 0.9 -0.6 -0.7 0.4 -0.1 -1.7 1.9 2.2
LDL Cholesterol 0.1 0.2 0.7 -0.9 -0.2 -0.4 -0.2 -0.2 0.6 -0.1 -0.3 -0.1 0.2 -0.5 -0.5
Lupus 0.4 0.5 2.0 -0.8 -0.8 -0.3 0.8 -1.0 -0.5 -0.6 -0.7 -1.4 0.2 -0.4 0.2
Neuroticism (2016) 1.0 1.4 3.8 -1.1 -0.7 -1.9 -0.9 -1.1 1.5 -1.0 1.7 -0.9 -0.8 -0.8 -1.1
Primary Biliary Cirrhosis 1.2 1.7 6.7 1.0 2.0 -0.5 -0.2 2.1 0.7 1.6 0.3 0.7 2.6 -0.8 -0.0
Rheumatoid Arthritis 0.6 0.9 2.7 0.7 1.0 -1.4 -0.8 1.0 0.2 1.4 1.6 0.4 0.5 -0.1 0.1
Schizophrenia (2014) 2.3 5.0 14.5 2.4 2.5 0.2 -0.4 0.3 1.9 2.7 1.9 3.8 2.2 3.3 1.7
Triglycerides 0.7 1.1 2.6 -1.3 -0.0 -1.1 -0.5 -1.2 -0.4 -0.7 -1.6 -1.6 0.6 -1.3 -1.2
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.2 -0.5 -0.6 0.7 0.7 -0.9 -0.9 -0.7 0.5 -0.9 -1.1 1.2 1.5
Ulcerative Colitis 0.3 0.5 2.5 0.6 -0.3 0.6 1.6 0.1 -0.1 -0.4 -0.8 -0.5 -0.1 0.9 0.9
Blood Eosinophil Count 0.0 0.3 1.0 0.3 0.4 0.9 -0.4 -0.4 1.0 0.0 -0.5 0.9 0.3 0.4 -0.1
Blood Platelet Count 0.1 0.8 2.1 0.7 0.6 0.4 1.2 1.0 0.6 0.7 -1.4 -0.5 1.4 -0.1 0.8
Blood Red Count 0.2 1.7 7.0 -1.2 -1.1 -1.2 0.7 -0.6 -1.9 -1.5 -0.6 -2.6 -0.9 -1.0 0.1
Blood White Count 0.2 1.7 6.5 -0.4 -0.1 0.4 0.4 0.8 -1.5 -1.6 -2.5 -2.5 0.3 -0.8 -0.6
Heel T-Score 0.1 1.0 3.8 0.2 0.2 -0.3 -0.5 0.1 -0.7 0.5 -1.9 -1.7 0.9 -1.3 -1.1
BMI 0.3 2.0 9.2 0.3 0.5 -0.1 -0.6 0.8 -2.4 -0.3 -3.0 -2.0 1.2 -1.2 -0.9
Height 0.1 1.9 10.6 -0.6 -0.9 -1.8 0.6 -1.3 1.6 -0.1 3.2 -0.6 -0.6 -0.6 -1.2
Waist Hip Ratio (WHR) 0.3 1.5 4.8 0.4 -0.1 0.5 1.1 1.1 -1.5 -0.9 -2.2 -1.6 -0.1 1.3 1.6
Systolic Blood Pressure 0.3 1.5 7.4 0.0 -1.0 0.1 2.7 1.0 -1.4 -1.6 -1.7 -1.0 0.2 0.3 -0.1
Smoking Status 0.7 1.7 2.4 -1.5 -1.5 -1.5 -0.6 -1.4 0.7 -1.1 1.5 -1.0 -1.4 -1.4 -1.4
Allergy or Eczema 0.4 1.0 4.2 0.6 0.7 0.9 -1.6 0.3 -2.0 1.2 -0.2 1.3 0.5 0.3 0.6
Cardiovascular Disease 0.6 2.0 9.7 -0.4 -0.3 0.3 1.0 1.1 -0.5 -0.6 -3.1 -1.7 1.9 -1.7 -1.5
Hypothyroidism (self reported) 0.7 1.6 3.9 -1.1 -1.4 -1.2 -0.2 -2.0 0.8 -1.8 0.5 -0.2 -1.7 -0.7 -1.7
Respiratory disease 0.6 1.3 5.0 1.2 1.5 -0.3 -1.0 0.3 -0.9 2.2 0.6 0.4 0.4 1.4 1.7
Type 2 Diabetes (T2D) (2018) 0.2 0.5 1.8 0.2 0.9 -0.9 -0.5 -0.3 -0.9 0.7 1.4 0.0 0.6 0.1 -0.3
Lung FEV1/FVC ratio 0.8 4.3 10.5 -1.8 -2.2 -2.2 1.6 -0.4 -3.1 -2.8 1.1 -3.2 -1.1 -1.8 -1.4
Lung FVC 1.1 5.6 11.0 -3.0 -2.7 -3.2 1.8 -2.6 0.6 -2.0 1.0 -2.5 -1.7 -3.3 -2.5
Neuroticism 1.1 2.7 8.0 -0.2 1.9 -1.3 -2.6 0.6 2.8 -0.6 1.2 0.4 2.2 -1.4 -1.9
Chronotype (morning person) 1.1 2.5 4.8 2.0 2.2 1.1 0.3 2.0 -0.5 2.1 1.1 1.4 1.8 1.8 1.2
Hair Pigment 0.0 0.7 2.9 0.9 -0.0 0.4 -0.3 0.2 -0.5 0.8 -0.3 -0.9 -1.5 0.8 1.7
Tanning 0.2 2.3 5.1 -2.1 -1.6 -1.3 -0.3 -1.2 -0.3 -2.2 0.1 -2.3 -0.1 -2.0 -1.7
Hand grip strength (left) 0.9 2.4 6.7 -2.6 -1.8 -1.0 -0.1 -1.8 0.4 -1.6 1.0 -2.2 -1.4 -1.6 -1.3
Number of treatments/medications taken 0.2 0.3 1.3 0.4 0.1 -0.8 -0.3 -0.1 0.5 1.0 -0.3 0.2 0.4 -0.4 -1.1
Average weekly spirits intake 1.4 1.7 4.3 -1.1 -0.6 -0.4 -0.1 -0.3 -1.5 -1.4 -1.9 -2.1 0.8 -2.1 -1.4
Sensitivity / hurt feelings 1.0 1.7 4.8 -0.8 0.1 -2.1 -0.8 -0.1 1.1 -0.7 2.2 -0.3 0.9 -1.9 -1.9
Frequency of depressed mood in last 2 weeks 1.2 1.7 6.2 -0.5 0.4 -1.8 -2.5 -0.8 -0.3 -0.1 2.2 -1.1 -0.6 -1.6 -0.8
Hearing difficulty/problems: Yes 0.2 0.3 1.3 -0.4 -0.5 -0.9 -0.2 -1.2 0.7 -0.3 0.3 -0.3 -0.5 -0.4 -0.3
Relative age of first facial hair 0.2 0.4 2.2 0.0 0.3 0.1 0.0 0.6 -1.5 -0.6 -0.6 -0.7 0.6 -0.5 -0.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.1 0.4 0.5 0.4 -0.2 1.0 0.9 0.3 -1.1 0.2 0.4 0.3 0.7
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.2 -0.7 -1.1 -1.3 0.3 -0.9 0.2 -0.7 0.2 -1.5 -0.4 -1.5 -1.4
Ever had hysterectomy (womb removed) 1.7 1.9 6.7 -1.9 -0.9 -2.6 -0.1 -1.7 0.6 -0.4 1.4 -0.5 -0.2 -1.5 -1.8
Systolic blood pressure, automated reading 0.4 1.2 5.9 0.7 -0.1 -0.3 2.4 1.1 -1.2 -0.5 -1.5 -1.2 1.0 0.5 0.5
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 4.3 1.0 0.7 0.3 -1.6 0.1 -0.8 1.9 0.3 1.5 0.7 1.7 2.1
Angina 0.4 0.6 1.8 -0.1 0.3 1.0 -1.1 -0.3 1.3 0.2 0.8 1.1 -0.6 0.6 0.5
Medication for hormone replacement therapy 0.3 0.3 1.4 -0.2 -0.4 -1.2 -0.5 -0.3 -0.3 -0.1 0.2 -0.8 -0.6 -0.4 -0.7
Vitamin and mineral supplements 1.9 2.6 8.7 -2.3 -1.7 -0.6 -1.8 -3.0 -0.1 -1.0 -1.8 -0.9 -1.0 -1.5 -1.5
Supplements: Zinc 2.1 2.2 4.9 2.0 1.6 0.8 0.9 1.6 0.2 1.4 0.6 1.9 0.9 2.2 2.1
Medication: Co-codamol 1.2 1.4 5.5 1.5 0.4 0.8 0.4 0.8 -1.1 1.6 0.3 0.9 -0.1 1.5 2.4
Medication: Metformin 0.2 0.3 1.5 -0.0 0.1 -0.5 -0.2 -0.6 -1.2 0.6 0.8 0.1 -0.1 0.1 -0.5
Diabetes (father) 1.2 1.5 3.8 -0.7 0.8 -0.4 -1.2 0.7 -0.1 -0.7 -1.8 -1.1 1.6 -1.9 -1.9
Diabetes (mother) 0.7 0.9 2.5 -1.5 -1.0 -0.7 1.3 -0.8 0.3 -1.6 0.2 -0.4 -0.9 0.3 -0.9
Severe depression (siblings) 0.7 0.8 5.5 0.4 1.2 -0.1 -0.2 0.6 2.3 0.1 0.2 0.3 1.4 -0.0 -0.3
Pack years adult smoking proportion 0.4 0.6 1.6 0.3 1.0 0.9 -1.2 0.5 -1.3 -0.6 0.4 0.5 0.5 1.0 0.6
Impedance of leg (right) 0.4 2.2 6.4 1.5 1.9 1.3 0.8 1.2 0.7 1.1 0.9 1.7 2.5 1.5 1.2
Leg fat-free mass (left) 0.5 2.5 6.4 -1.8 -1.4 -1.3 -1.1 -1.0 0.4 -1.5 -1.0 -2.4 -1.3 -2.5 -1.8
Trunk fat percentage 0.6 2.3 15.1 1.1 1.0 1.6 0.2 0.8 -1.7 0.0 -3.9 -0.1 1.9 0.1 -0.3
Hand grip strength (right) 1.2 3.2 8.7 -2.5 -1.5 -2.2 0.4 -0.7 0.3 -1.7 1.6 -3.0 -0.8 -2.4 -2.0
Townsend deprivation index at recruitment 3.4 4.7 10.7 3.3 2.9 2.4 -0.3 1.9 0.8 2.5 -0.6 2.7 1.8 2.2 2.4
Current tobacco smoking 0.3 0.5 2.1 0.4 -0.7 0.5 1.4 0.8 -0.4 -0.8 0.7 0.8 -0.5 0.3 0.3
Average weekly fortified wine intake 0.7 0.8 3.8 0.1 -0.4 1.0 0.0 0.1 -0.7 0.2 -0.4 -0.5 -0.7 1.7 2.0
Maternal smoking around birth 0.5 0.7 2.8 -0.3 -0.5 -1.6 0.6 -0.4 1.7 -1.2 0.6 -0.6 -0.2 0.1 -0.4
Fed-up feelings 0.9 1.6 4.6 1.0 2.0 -0.7 -1.0 1.3 1.8 0.8 1.4 -0.0 2.1 -0.8 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.5 -0.2 0.8 -1.7 -1.9 0.5 -1.3 0.0 1.4 -0.7 0.8 -1.4 -0.2
Relative age voice broke 0.3 0.4 1.8 0.1 0.4 0.9 0.5 0.4 -0.7 -0.3 -0.3 -0.0 0.2 1.2 1.3
Taking other prescription medications 0.1 0.2 0.8 0.2 0.5 0.0 -0.7 0.2 0.5 0.4 0.2 0.9 0.1 0.4 0.2
Age when periods started (menarche) 0.5 1.1 5.4 -0.8 -1.7 -0.4 2.3 -0.8 0.2 -0.5 -0.9 -0.4 -1.1 0.9 0.0
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 3.5 -1.1 -0.6 -1.5 -0.2 -0.6 -1.2 -0.9 -0.4 -0.7 0.3 -1.9 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 5.4 -0.7 -0.9 -1.4 0.2 -0.5 -1.0 -0.8 -1.7 -2.3 -0.3 -1.4 -1.1
Tinnitus: Yes, but not now, but have in the past 2.3 2.4 5.5 1.8 2.4 0.8 -1.9 1.7 1.8 1.8 -0.1 1.4 2.1 0.4 0.8
Qualifications: CSEs or equivalent 1.6 2.1 7.1 -1.2 -0.8 -0.6 0.7 -0.1 1.1 -2.5 0.0 -2.1 0.3 -2.7 -1.9
Serious illness, injury or assault to yourself 1.3 1.5 5.0 1.5 1.9 0.4 -0.4 2.2 -0.1 1.5 -0.2 1.4 1.5 0.8 0.7
High blood pressure 0.1 0.4 2.5 -0.3 -0.4 0.4 1.1 0.1 -0.5 -0.2 -1.6 -0.2 0.4 -0.0 -0.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.6 -0.1 0.3 1.2 -1.6 0.4 -1.1 -0.2 -0.4 0.7 0.0 -0.8 -0.6
Multivitamins +/- minerals 1.9 2.4 7.3 2.7 1.3 1.6 1.4 2.5 0.0 0.7 1.0 0.5 0.4 1.6 2.1
Stomach or abdominal pain in last month 0.7 0.9 3.3 -0.7 -0.3 -0.4 -1.0 0.1 -0.0 -1.2 -1.8 -1.5 0.5 -1.1 -0.8
Supplements: Glucosamine 0.6 0.8 5.2 0.5 0.2 -0.5 0.4 1.4 0.8 0.7 2.3 -0.1 -0.2 -0.5 -0.0
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 4.0 -0.1 0.7 0.6 -0.2 0.7 2.0 -0.2 -0.2 -0.7 1.1 -1.1 -1.4
Medication: Atenolol 0.6 0.8 3.0 0.8 0.6 1.3 0.5 0.4 -0.7 0.7 -0.8 1.7 0.5 1.2 -0.0
Medication: Levothyroxine sodium 1.6 2.7 6.5 -2.5 -1.4 -1.0 -1.0 -2.2 0.2 -2.0 -0.9 -1.4 -1.0 -1.6 -2.5
Sitting height 0.4 3.2 9.2 -1.4 -0.4 -1.9 -2.3 -1.3 3.0 0.3 2.5 -0.6 -0.4 -2.4 -1.9
Chronic bronchitis/emphysema (father) 0.3 0.3 1.2 0.4 -0.1 0.4 0.5 0.1 0.8 0.0 -1.1 -0.1 0.6 -0.8 -0.5
High blood pressure (mother) 0.8 1.2 2.9 -1.2 -1.1 -1.7 -0.7 -1.5 -0.4 0.2 0.8 -1.0 -0.9 -1.3 -1.1
Body mass index (BMI) 0.4 1.5 7.6 -0.5 -0.6 0.1 -0.5 -0.6 -1.6 -1.1 -2.8 -1.9 -0.3 -1.2 -0.8
Impedance of leg (left) 0.5 2.5 8.7 1.7 2.3 1.3 0.3 1.3 0.5 1.2 0.7 1.8 2.9 1.7 1.3
Leg predicted mass (left) 0.5 2.4 6.3 -1.8 -1.4 -1.3 -1.1 -0.9 0.4 -1.4 -1.2 -2.5 -1.2 -2.5 -1.8
Trunk fat mass 0.4 1.6 12.1 0.3 0.4 0.8 -0.2 0.2 -1.4 -0.4 -3.5 -1.0 1.2 -0.8 -0.9
Waist circumference 0.4 1.3 9.5 0.4 0.2 0.7 -0.3 0.4 -1.8 -0.3 -3.1 -1.4 0.6 -0.4 0.1
Number of incorrect matches in round 1.1 1.9 6.2 1.7 2.2 0.9 0.3 1.5 0.3 1.3 -1.4 1.2 2.5 0.3 -0.2
Past tobacco smoking 0.4 0.7 2.8 1.0 0.3 1.7 0.5 0.6 -0.9 0.0 -0.6 0.6 0.3 0.9 1.3
Alcohol usually taken with meals 1.2 1.9 4.2 -1.7 -0.6 -1.0 -2.0 -1.3 -0.8 -1.2 -0.3 -1.8 -0.6 -1.7 -1.9
Nervous feelings 0.7 1.4 4.3 1.2 1.1 -0.4 -0.3 0.4 2.1 1.1 1.5 1.5 0.5 1.4 0.9
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.7 8.0 2.4 2.8 0.7 -1.9 1.3 -0.9 2.7 0.9 2.4 1.8 1.6 2.0
Hearing difficulty/problems with background noise 0.3 0.5 2.5 0.5 0.6 -1.3 0.0 0.0 1.6 0.9 -0.0 -0.3 0.7 -0.6 -0.1
Hair/balding pattern: Pattern 2 1.7 2.2 6.1 2.1 1.3 0.4 1.9 2.5 -0.4 0.7 -0.8 -0.8 0.9 1.8 2.1
Had menopause 0.5 0.7 1.8 -0.8 -1.0 -0.6 0.4 -0.6 -0.8 -1.3 -0.6 -1.3 -0.7 -0.3 -0.6
Had other major operations 3.2 3.9 12.5 -3.5 -2.3 -1.9 -0.9 -2.1 0.7 -1.6 0.8 -1.1 -2.0 -2.7 -2.1
Forced vital capacity (FVC) 1.3 5.2 12.0 -2.5 -1.9 -2.4 1.0 -1.3 3.0 -2.4 1.2 -3.5 -0.9 -3.2 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 6.5 -0.7 -1.1 -0.1 -0.7 -0.7 -0.9 -1.0 -2.5 -2.2 -1.0 -1.4 -0.7
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 8.6 0.0 0.3 -0.6 -2.9 -0.1 0.3 1.1 0.8 1.1 -0.3 0.1 0.3
Qualifications: None of the above 0.3 0.5 3.1 0.0 0.3 -1.8 -0.0 0.4 1.0 -0.7 -0.1 -1.1 0.4 0.3 -0.4
Financial difficulties in last 2 years 2.6 3.5 6.6 2.5 2.5 2.1 -0.9 1.7 0.2 1.7 -0.8 1.6 1.7 2.3 2.6
Mouth/teeth dental problems 1.0 1.5 5.3 -1.1 -1.1 0.0 1.0 0.5 -0.8 -1.9 -0.7 -2.3 0.0 -1.6 -1.1
Heart attack 0.8 1.0 4.6 -0.3 -0.5 -0.0 0.1 -0.3 1.6 -0.3 2.1 1.1 -1.4 0.7 -0.4
Allergy 0.3 0.7 3.6 0.5 0.2 -0.8 1.6 0.4 1.9 0.5 0.1 0.1 1.1 0.1 0.2
Pain all over the body in last month 0.3 0.3 1.4 -0.9 -0.4 -1.1 -0.2 0.0 0.4 -1.2 0.0 -0.2 -0.1 0.4 -0.2
Diabetes (self-reported) 0.5 0.8 2.6 -1.0 -0.4 -1.6 -0.6 -1.2 -0.8 0.3 0.8 -0.2 -0.6 -0.6 -1.4
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.3 -0.4 -0.4 -0.3 -0.4 0.3 -0.6 -0.4 0.6 -0.6 -0.2 -1.2 -1.0
Medication: Ramipril 1.2 1.6 5.0 -1.4 -1.3 -1.3 0.5 -1.6 1.0 -0.9 2.2 0.6 -1.4 -0.1 -1.2
Medication: Simvastatin 0.6 0.9 3.2 -1.1 -0.9 -0.2 0.5 -1.5 -0.1 -0.6 -0.3 -0.1 -0.4 -1.4 -1.8
Fluid intelligence score 0.6 1.2 5.4 -0.7 -1.4 1.6 -0.4 -1.4 -0.8 -0.2 -1.0 0.1 -2.3 0.1 0.5
Illnesses of siblings 0.3 0.4 2.9 -0.3 -0.0 0.9 -1.7 0.1 0.8 -0.6 -0.2 0.0 -0.4 0.1 0.2
Neuroticism score 1.5 3.1 9.4 0.4 2.1 -1.7 -2.4 0.7 3.1 0.2 2.1 0.4 2.3 -1.2 -1.4
Weight 0.3 1.7 5.4 -0.9 -0.6 -0.4 -0.8 -0.8 -0.7 -1.0 -2.3 -2.2 -0.2 -1.9 -1.5
Impedance of arm (right) 1.0 4.6 10.2 2.5 2.0 3.2 1.0 2.0 0.2 2.0 -0.6 3.0 2.3 2.5 2.1
Arm fat percentage (right) 0.3 1.3 10.3 0.6 -0.2 1.5 0.4 0.2 -1.3 -0.3 -3.2 -0.9 0.2 -0.2 0.1
Trunk fat-free mass 0.6 3.6 9.0 -2.3 -1.4 -1.8 -1.4 -1.6 1.2 -1.4 0.2 -2.9 -1.6 -3.0 -2.1
Hip circumference 0.1 0.5 2.9 -0.1 0.0 0.6 -0.6 -0.5 -0.3 0.2 -1.7 -0.9 0.2 -1.3 -0.3
Time employed in main current job 0.5 0.5 1.5 -0.2 0.8 -1.0 -0.7 -0.4 0.2 1.0 -0.3 0.7 0.8 0.0 -1.2
Alcohol intake versus 10 years previously 0.2 0.3 1.6 -0.5 -0.3 -0.6 0.5 -0.1 -1.3 -0.5 0.4 -0.7 -0.0 -0.3 -0.6
Father’s age at death 0.8 1.0 2.8 -1.2 -0.5 -0.2 -1.6 -1.3 -0.6 -0.9 -0.3 -1.3 -0.7 -1.7 -0.5
Worrier / anxious feelings 0.6 1.1 3.1 -0.5 -0.3 -1.0 -0.0 -0.1 1.0 -1.8 0.9 -1.3 0.4 -1.6 -1.7
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 3.0 0.9 1.7 -1.4 -1.3 0.4 -0.0 1.1 1.2 -0.1 1.3 0.3 1.1
Falls in the last year 0.4 0.6 1.8 -0.8 -0.6 -1.4 -0.8 -0.4 -0.3 -0.8 -0.2 -1.2 -0.8 -0.6 -0.8
Hair/balding pattern: Pattern 3 0.3 0.5 2.9 0.1 0.1 0.2 -0.1 -0.5 -0.4 1.0 0.7 1.7 0.6 -0.6 -0.3
Number of live births 2.2 3.2 4.8 -2.1 -1.9 -2.2 2.1 -2.2 1.5 -1.2 2.0 -0.9 -1.4 -1.6 -1.7
Forced expiratory volume in 1-second (FEV1) 2.3 7.8 19.5 -2.9 -2.0 -3.3 1.2 -1.0 2.8 -2.8 2.2 -4.3 -0.8 -4.4 -2.8
Pulse rate 1.6 2.6 4.7 2.1 1.3 0.5 1.4 2.2 -1.2 1.9 -1.4 0.3 1.9 1.9 2.1
Happiness 0.6 0.8 2.5 0.7 0.6 -0.0 -0.4 0.2 1.3 1.6 1.0 1.4 0.6 0.6 0.5
Noisy workplace 0.2 0.2 0.5 0.4 -0.4 0.1 0.6 0.3 -0.7 -0.1 -0.5 -0.7 -0.4 0.3 0.3
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.5 -0.7 -1.1 0.9 -0.1 -1.2 1.2 0.4 0.3 0.4 -1.6 -0.0 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.0 -1.4 -1.1 -0.8 0.5 -1.4 -1.0 -0.6 -0.5 -0.8 -1.1 -0.2 -0.0
Mouth/teeth dental problems: Dentures 0.6 1.0 3.6 -1.0 -0.9 -1.9 -0.1 -0.7 0.6 -0.5 0.6 -0.4 -1.1 -1.0 -1.8
Asthma 0.4 0.7 1.5 0.4 0.8 0.7 -1.1 -0.1 -1.0 1.2 0.5 0.6 -0.3 1.2 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.3 0.8 1.0 -1.0 0.1 1.0 0.5 0.9 -0.0 -0.9 1.5 -1.5 -0.5
Medication: Cholesterol lowering 0.7 1.0 5.2 -1.0 -1.2 -0.1 -0.4 -2.3 0.5 -0.3 0.1 0.6 -1.4 -0.4 -1.2
Depression (self-reported) 1.2 1.4 4.3 0.2 0.7 -1.9 -0.4 0.2 1.3 1.0 2.1 -0.8 0.8 -1.4 -1.6
Medication: Lansoprazole 2.4 2.7 8.8 2.0 2.5 0.7 0.4 1.2 -1.3 2.2 -0.7 2.0 3.0 0.8 0.0
Prospective memory result 0.5 0.6 1.9 -0.0 0.6 -1.1 -1.2 -0.1 1.4 0.1 1.2 -0.0 0.3 -0.2 -0.6
Lung cancer (father) 0.2 0.2 0.9 -0.5 0.3 -0.2 0.3 0.0 -0.7 -0.4 -0.2 -0.6 0.6 -0.5 -0.9
Illnesses of mother 0.2 0.3 2.0 0.2 -0.1 0.3 0.4 0.6 1.4 -0.7 0.1 -0.1 0.3 -0.1 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.8 17.4 -2.4 -1.5 -2.7 0.8 -0.7 2.0 -2.5 1.6 -3.9 -0.4 -4.2 -2.8
Pulse wave Arterial Stiffness index 0.4 0.5 1.6 -0.2 0.8 -0.5 -0.5 0.8 -1.3 -0.3 -0.4 -0.6 0.9 -0.5 -0.9
Impedance of arm (left) 0.9 4.0 8.4 2.6 1.8 2.6 1.2 1.9 0.2 2.0 -0.7 2.9 2.2 2.3 1.7
Arm fat mass (right) 0.3 1.2 7.0 -0.3 -0.5 0.4 -0.1 -0.4 -0.7 -0.9 -2.7 -1.8 -0.1 -1.3 -0.8
Trunk predicted mass 0.7 3.7 9.1 -2.4 -1.5 -1.8 -1.5 -1.7 1.4 -1.5 0.2 -2.9 -1.6 -3.0 -2.1
Standing height 0.1 1.1 4.2 -0.7 0.4 -1.0 -0.7 -0.1 2.1 0.2 0.7 -0.7 0.8 -1.6 -1.6
Length of working week for main job 0.4 0.4 1.3 -0.7 -0.0 0.2 -1.0 0.2 0.4 -0.3 -1.0 -0.9 0.2 -1.1 -0.4
Exposure to tobacco smoke at home 0.4 0.4 1.6 -0.0 0.8 -0.4 -1.2 0.8 0.4 -0.2 0.5 -1.0 0.3 -0.9 0.0
Breastfed as a baby 1.5 1.8 6.3 -1.0 -0.2 -2.4 0.9 -0.8 -0.8 0.2 -0.2 -1.3 1.1 -1.9 -2.5
Tense / ‘highly strung’ 0.9 1.5 3.4 1.2 1.7 -0.7 -0.9 0.2 1.1 1.1 1.3 1.9 1.8 0.9 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 2.2 -1.1 -0.5 -1.5 -1.4 -1.1 0.7 -0.6 1.5 0.1 -1.2 -0.9 -1.5
Hair/balding pattern: Pattern 4 0.8 1.8 3.9 -1.7 -1.1 -0.7 -1.5 -1.6 -0.1 -1.5 0.4 -0.8 -1.5 -1.8 -2.0
Birth weight of first child 0.4 0.7 1.8 -0.7 -1.2 0.1 -0.7 -0.5 1.3 -1.1 -0.1 -0.8 -1.0 -0.6 -0.0
Peak expiratory flow (PEF) 2.7 6.3 14.8 -1.2 -0.6 -3.6 2.2 1.0 3.4 -0.8 3.8 -3.2 0.1 -3.7 -2.3
Pulse wave reflection index 0.8 1.0 2.5 -0.8 -0.7 -0.2 0.3 -0.2 -1.6 -1.4 -0.2 -1.6 -0.8 -1.2 -1.3
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.8 -0.2 0.1 -0.6 -0.9 0.8 0.7 0.2 0.8 -0.4 -0.0 -0.6 -0.3
Loud music exposure frequency 0.6 0.7 2.9 0.8 0.1 0.3 -0.5 -0.8 -0.0 1.2 0.0 0.8 -0.2 1.1 1.7
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.7 -0.4 0.2 -0.8 -0.7 -0.1 -0.7 1.1 1.4 0.9 0.2 -1.7 -1.2
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.3 0.2 1.2 0.7 -1.5 -0.3 0.5 1.5 -0.5 1.4 0.9 0.7 1.4
Blood clot in the leg (DVT) 0.4 0.5 1.5 0.6 -0.2 -1.2 1.0 -1.0 -1.0 0.7 -0.0 -0.5 -0.5 -0.0 -0.4
Medication: Paracetamol 0.4 0.6 2.0 0.7 1.0 -0.9 -0.4 0.4 1.4 0.3 0.7 0.1 1.3 -0.5 -0.5
Headache pain in last month 0.5 0.9 2.7 0.4 0.9 -1.5 -1.6 0.6 0.5 -0.0 0.8 -1.2 0.4 -0.8 -0.9
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.1 0.4 1.1 0.1 -1.4 1.3 -0.8 0.6 0.7 -0.1 0.8 -0.1 0.8
Glaucoma (self-reported) 0.7 0.8 2.1 0.4 -0.7 0.1 0.7 -0.6 -1.1 0.1 0.9 1.1 -1.4 1.3 1.2
Gout (self-reported) 0.4 0.6 2.0 -0.8 -0.1 0.5 -0.6 -0.2 -0.5 -1.2 -0.9 -1.0 -0.2 -1.4 -0.6
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 3.9 -1.5 -1.3 -1.0 -0.7 -2.0 0.1 -1.8 -0.5 -0.8 -1.3 -0.9 -2.0
Medication: Amlodipine 0.3 0.5 1.7 -1.0 -0.4 -0.1 -0.2 -0.5 0.6 -1.3 -0.4 -0.7 -0.3 -0.7 -1.0
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.7 -0.2 0.0 -0.6 -0.6 0.4 0.2 0.2 -0.4 -0.8 -0.4 -0.2 0.5
Birth weight 0.2 0.3 1.0 -0.5 -0.1 -0.6 -0.9 -0.3 0.1 -0.7 0.7 0.1 0.1 -1.0 -0.7
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.4 0.7 0.7 0.4 -0.4 0.2 -1.6 0.0 -0.8 1.4 0.7 1.4 -0.1
High blood pressure (siblings) 0.5 0.7 3.9 -0.1 0.1 -2.0 0.6 -0.5 -0.3 0.9 1.0 -0.4 0.6 -0.9 -0.3
Forced vital capacity (FVC), Best measure 1.1 4.2 10.5 -2.3 -1.3 -2.4 0.5 -1.2 2.3 -1.9 1.1 -3.0 -0.4 -3.2 -2.5
Body fat percentage 0.5 1.8 13.0 0.8 0.5 1.3 0.4 0.5 -2.0 -0.2 -3.6 -0.7 1.4 -0.1 -0.2
Leg fat percentage (right) 0.3 1.1 7.0 0.5 0.4 0.8 0.3 0.1 -1.8 -0.1 -2.6 -0.8 1.0 -0.2 -0.1
Arm fat-free mass (right) 0.8 3.9 9.8 -2.3 -1.3 -2.6 -1.3 -1.4 0.4 -1.9 -0.2 -3.1 -0.9 -3.1 -2.4
Exposure to tobacco smoke outside home 1.2 1.6 6.9 1.7 1.3 1.6 0.5 1.2 -0.6 0.7 -0.1 0.3 0.9 1.5 2.6
Comparative body size at age 10 0.5 1.4 8.3 1.0 1.6 0.5 -2.9 0.2 0.6 1.6 0.6 -0.1 0.7 -0.1 0.5
Number of full brothers 0.3 0.4 1.8 0.5 0.5 -0.8 -0.2 0.6 -1.4 0.8 0.2 0.2 0.8 -0.1 0.0
Worry too long after embarrassment 1.3 2.2 6.8 -1.1 0.4 -2.6 -2.0 -0.4 1.5 -0.7 0.1 -1.1 1.3 -2.2 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.8 -0.5 -0.2 -0.8 -0.3 0.2 -1.7 -0.1 1.1 -0.4 -0.8 0.2 -0.0
Wheeze or whistling in the chest in last year 0.5 0.8 3.1 0.1 0.9 -1.6 -1.2 0.1 -1.8 0.8 -0.5 -0.0 0.9 -0.6 -0.2
Number of children fathered 1.3 1.4 4.3 -0.8 0.2 -2.1 1.4 -0.4 0.3 0.4 1.3 -0.7 1.2 -1.6 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 2.3 -0.8 -0.7 -1.1 -0.8 -1.5 0.7 0.7 1.5 -0.7 -0.5 -1.0 0.4
Age at first live birth 0.7 1.2 5.2 0.3 0.1 1.4 -0.1 0.1 -2.3 0.5 -1.5 1.0 0.2 1.5 0.9
Pulse wave peak to peak time 0.5 0.6 2.5 0.2 -0.8 0.7 0.4 -0.9 1.6 0.2 0.4 0.7 -1.1 0.5 0.9
Health satisfaction 2.0 2.7 4.6 2.2 1.7 1.9 -1.2 1.4 0.2 1.9 -1.3 1.9 1.3 1.8 1.9
Shortness of breath walking on level ground 0.8 1.0 2.2 1.0 1.3 0.2 -1.5 0.8 1.1 0.9 0.5 0.6 0.3 1.3 1.3
Qualifications: College or University degree 0.4 1.3 3.1 0.3 -0.4 1.8 -1.3 -1.1 -0.9 1.3 -0.6 1.4 -1.4 0.8 1.3
Eye problems/disorders: None of the above 0.6 0.7 2.1 -1.0 -0.5 0.7 -1.0 -1.4 0.5 -1.2 -0.1 -0.1 -1.2 0.2 0.0
Mouth/teeth dental problems: Loose teeth 1.3 1.5 5.7 0.7 0.8 0.0 -0.6 -0.2 0.5 1.9 2.4 1.7 -0.3 1.4 1.3
Emphysema/chronic bronchitis 1.5 1.6 3.1 -1.4 -0.8 -1.5 -0.8 -0.8 -1.6 -1.0 -1.8 -1.8 -0.5 -1.3 -1.3
Medication for pain relief, constipation, heartburn 0.4 0.6 3.0 0.6 0.7 1.7 -0.1 0.8 -0.7 0.0 -0.5 0.7 -0.1 0.8 1.2
Neck or shoulder pain in last month 0.4 0.6 4.8 0.0 0.3 -0.4 -2.2 -0.6 0.3 0.6 0.3 -0.5 -0.2 -0.2 0.6
Medication: Blood pressure 0.4 0.7 2.4 -0.5 -0.9 0.3 1.5 -1.0 0.7 -1.3 -0.8 -0.5 -0.4 0.4 -0.5
Angina (self-reported) 0.4 0.6 1.6 -0.3 0.2 1.0 -1.2 -0.5 1.0 0.1 0.9 0.9 -0.8 0.5 0.5
Migraine (self-reported) 0.8 1.0 3.2 -1.1 -0.8 -0.8 -1.8 -1.0 -0.7 -0.7 0.5 -1.5 -1.2 -0.3 0.6
Medication: Ibuprofen 1.1 1.3 3.8 1.0 1.4 -1.7 -0.3 1.1 0.1 1.1 -0.1 -0.6 2.0 -1.5 -1.0
Medication: Allopurinol 0.7 0.9 2.8 0.5 0.7 1.6 -1.2 0.4 -1.4 0.4 -1.7 0.9 0.6 0.1 0.4
Medication: Omeprazole 0.3 0.4 1.0 -1.0 -0.9 -0.6 0.9 -0.2 -0.0 -0.6 0.7 -0.4 -0.4 -0.6 -0.6
Medication: Seretide 50 evohaler 0.5 0.6 2.0 -0.4 0.1 0.9 -1.1 -0.3 -0.7 -0.7 -1.4 -1.1 -0.0 0.4 0.4
Mean time to correctly identify matches 7.3 14.0 27.9 5.3 5.1 3.4 -0.2 4.3 -1.1 4.2 -1.4 4.1 3.7 4.6 3.4
Heart disease (mother) 0.5 0.6 1.8 -0.6 -0.4 -1.0 -0.3 -0.2 1.0 -0.4 0.9 -1.3 -0.0 -1.2 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 2.5 -0.6 -0.8 -1.2 0.2 -1.6 1.0 -0.4 1.2 0.6 -1.2 0.8 -0.2
Whole body fat mass 0.3 1.4 9.4 -0.1 -0.0 0.5 -0.2 -0.1 -1.4 -0.6 -3.1 -1.6 0.7 -1.1 -0.9
Leg fat mass (right) 0.3 1.3 5.8 -0.6 -0.4 -0.1 -0.5 -0.5 -1.1 -0.9 -2.4 -1.9 0.2 -1.5 -1.2
Arm predicted mass (right) 0.8 4.1 10.6 -2.4 -1.3 -2.7 -1.3 -1.4 0.6 -1.8 -0.3 -3.1 -0.9 -3.3 -2.5
Pulse rate, automated reading 0.9 2.9 6.9 2.6 1.4 0.2 2.2 2.6 -0.9 1.8 -1.0 0.3 1.8 1.4 1.8
Alcohol intake frequency. 0.3 0.7 2.1 -0.3 -0.0 -1.4 -0.1 -0.2 -1.3 -0.8 -0.4 -1.2 0.6 -0.7 -1.4
Comparative height size at age 10 0.1 0.8 3.4 0.2 0.7 -0.9 -0.7 -1.0 0.8 1.9 -0.1 0.4 0.8 -1.0 -0.7
Number of full sisters 2.2 2.6 9.5 1.4 1.7 -1.1 -0.4 1.2 3.1 1.8 2.6 1.4 1.2 0.8 0.9
Suffer from ‘nerves’ 0.8 1.2 6.6 0.2 1.3 -1.3 -2.6 -0.9 0.3 0.5 1.1 0.3 1.4 -0.2 -0.2
Overall health rating 1.2 2.5 4.4 2.1 2.1 1.6 -1.8 1.4 -0.2 1.2 -1.4 1.3 1.3 1.9 1.7
Chest pain or discomfort 0.7 1.0 3.9 1.2 1.4 -0.7 -0.8 0.5 -0.1 2.0 0.2 0.9 0.4 1.0 1.4
Had major operations 1.9 2.3 4.6 -2.1 -1.1 -0.1 -1.5 -1.7 -1.7 -1.6 -1.3 -0.8 -1.0 -1.6 -2.1
Age at last live birth 0.6 0.9 3.1 0.5 0.2 0.4 -0.9 -0.9 -0.4 1.2 0.2 1.8 -0.4 1.4 1.1
Family relationship satisfaction 0.8 1.0 2.7 1.3 0.7 0.5 -0.3 0.3 0.9 1.6 0.6 1.6 -0.1 1.3 1.2
Leg pain on walking 0.7 0.8 4.3 0.3 0.7 0.6 -2.1 -0.3 -0.8 -0.6 -1.2 0.2 0.9 -0.9 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.6 0.1 0.0 -1.6 1.6 -0.1 -0.6 -0.2 -0.2 -0.9 0.6 -1.4 -1.1
Commuting to job workplace: Car/motor vehicle 0.6 0.7 3.0 0.1 0.5 -0.2 1.0 0.8 -0.5 -0.0 -0.1 0.7 1.0 -1.3 -1.7
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 4.2 -0.5 -0.7 -1.5 1.3 -0.2 1.4 -0.3 2.1 -0.5 -0.5 -0.6 -0.6
Medication: Aspirin 0.6 0.8 3.5 -0.8 -1.6 -0.3 0.1 -1.3 -0.2 -0.3 0.8 0.1 -1.9 0.6 -0.2
Supplements: Vitamin C 0.6 0.8 2.7 1.1 0.9 0.5 0.9 1.3 1.7 0.2 0.7 0.4 0.8 0.4 -0.1
Knee pain experienced in last month 0.5 0.8 1.9 1.0 1.3 1.3 -0.6 0.6 -0.1 0.8 -0.6 1.4 1.2 0.2 0.6
Hypertension (Self-reported) 0.1 0.4 3.1 -0.1 -0.3 0.3 1.0 0.2 -0.3 0.2 -1.8 -0.0 0.7 0.1 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 2.3 -0.2 0.1 -0.6 1.5 0.3 0.3 0.2 1.3 0.9 0.2 0.3 -0.3
Illnesses of father: Heart disease 1.1 1.5 6.7 -1.1 -2.0 -0.1 0.8 -2.6 0.5 -1.1 0.6 -0.2 -1.9 0.3 0.3
Illnesses of siblings: Diabetes 0.7 0.8 4.4 -0.5 -0.5 1.8 0.6 0.3 0.2 -0.1 -2.1 -0.7 0.1 -0.1 0.8
Smoking status: Previous 1.2 1.8 5.8 -1.5 -0.3 -2.4 -1.4 -1.2 1.0 -0.1 0.4 -1.3 -0.2 -1.8 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.8 3.9 -1.2 -0.5 -1.9 -1.5 -0.8 2.0 -0.4 1.0 -1.7 -0.1 -2.0 -1.1
Whole body fat-free mass 0.6 3.2 8.4 -2.1 -1.4 -1.6 -1.5 -1.3 0.9 -1.5 -0.3 -2.8 -1.4 -2.9 -2.0
Leg fat-free mass (right) 0.5 2.5 5.8 -1.8 -1.4 -1.3 -1.4 -1.0 0.3 -1.5 -1.1 -2.4 -1.3 -2.4 -1.8
Arm fat percentage (left) 0.3 1.4 10.7 0.5 -0.4 1.1 0.6 0.1 -1.5 -0.4 -3.3 -1.1 0.2 -0.4 -0.2
Average weekly red wine intake 0.3 0.4 1.6 -0.1 -0.4 0.1 -0.6 -0.4 0.7 -0.0 -0.8 -1.3 0.0 -0.9 -0.6
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.8 -1.1 -0.7 0.1 -1.7 -1.6 -0.8 -1.0 -1.2 -1.6 -1.4 -0.7 -0.9
Mood swings 1.2 2.1 9.4 -0.7 0.4 -1.9 -1.5 0.1 1.7 -0.8 3.1 -1.2 0.5 -1.5 -1.2
Loneliness, isolation 0.4 0.6 1.6 -0.7 0.0 -1.2 -0.8 -1.1 0.3 -1.1 0.2 -0.2 -0.2 -0.2 -1.3
Long-standing illness, disability or infirmity 0.3 0.5 2.3 0.6 0.3 1.1 -0.4 0.2 -0.3 0.3 -1.5 0.5 -0.2 0.9 0.8
Ever had bowel cancer screening 0.4 0.5 2.2 -0.4 0.1 -1.5 -0.3 -0.1 -0.4 1.1 1.3 0.5 0.2 -0.1 -0.2
Diabetes diagnosed by doctor 0.7 1.1 4.2 -1.0 -0.3 -2.1 -0.9 -1.5 -0.6 0.3 1.5 -0.4 -0.6 -0.6 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 2.8 3.0 8.3 2.1 2.1 1.5 -0.6 1.0 0.9 2.9 0.5 1.8 2.1 1.6 2.0
Friendships satisfaction 0.2 0.3 1.8 -0.0 0.1 0.4 0.5 0.3 1.3 0.3 0.3 0.8 0.0 0.1 0.5
Qualifications: nursing, teaching 1.0 1.6 3.6 -1.8 -1.9 -0.8 0.1 -1.6 -0.9 -1.5 -0.3 -0.6 -1.5 -1.2 -1.4
Commuting to job workplace: Walk 1.1 1.2 3.8 -0.9 -1.7 0.5 -0.7 -1.9 -0.1 -0.5 -1.1 -1.1 -2.0 -0.4 -0.2
Eye problems/disorders: Cataract 0.6 0.7 2.2 -0.4 -0.2 -0.3 1.0 1.1 -0.8 -0.7 -0.1 -1.5 0.5 -1.2 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 4.0 1.4 0.4 0.1 0.3 0.6 0.0 2.0 0.6 0.8 -0.6 1.1 1.7
Medication for cholesterol 0.7 1.1 4.6 0.7 1.0 0.3 -0.5 0.1 1.4 0.5 1.0 0.3 0.1 1.7 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.9 -1.4 -0.9 -1.7 -0.6 -1.3 1.6 0.2 0.7 -0.1 -0.5 -1.6 -1.2
Back pain experienced in last month 0.8 1.2 3.5 0.1 0.5 -1.8 -0.7 0.6 1.3 0.0 1.9 -0.8 1.0 -1.3 -1.0
Mineral and other dietary supplements 0.9 1.2 3.3 -1.8 -1.2 -0.4 -1.2 -1.8 -0.5 -0.8 -1.1 -1.3 -0.6 -0.9 -0.4
Breast cancer (self-reported) 0.7 0.8 3.3 -0.8 -0.7 0.2 -0.3 0.1 -1.8 -1.5 -0.8 -1.2 -0.3 -0.2 -0.6
Asthma (self-reported) 0.6 1.2 3.2 0.8 1.3 1.1 -1.1 0.5 -1.0 1.5 0.2 0.8 0.1 1.6 1.8
Osteoporosis (self-reported) 0.4 0.5 1.8 0.4 0.7 0.5 -0.8 0.7 0.4 0.3 -0.3 1.3 0.4 1.1 0.4
Osteoarthritis (self-reported) 1.7 2.3 3.8 1.7 1.5 1.8 -0.6 1.6 -1.9 1.3 -2.0 1.4 0.9 1.3 1.3
Medication: Aspirin 0.4 0.5 1.8 -0.3 -0.9 0.0 -0.1 -1.1 -0.2 0.3 0.4 0.9 -1.3 1.2 -0.0
Medication: Gliclazide 0.3 0.4 1.1 0.5 0.4 -0.8 -0.1 0.3 -1.1 1.1 0.3 -0.1 0.8 -0.2 0.4
Illnesses of father: None of the above (group 1) 0.3 0.4 1.6 0.6 0.4 -0.1 1.1 1.3 -0.9 0.0 0.5 -0.1 0.1 -0.1 -0.5
Smoking status: Current 0.3 0.5 1.9 0.4 -0.8 0.7 1.4 0.7 -0.3 -0.9 1.0 0.8 -0.5 0.3 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.2 4.6 9.2 -2.4 -2.4 -2.3 1.5 -1.6 -0.0 -2.8 0.4 -2.8 -1.0 -3.0 -2.7
Whole body water mass 0.6 3.4 8.6 -2.2 -1.5 -1.8 -1.3 -1.4 0.9 -1.6 -0.3 -2.8 -1.5 -2.9 -2.1
Leg predicted mass (right) 0.4 2.4 5.7 -1.8 -1.2 -1.2 -1.4 -0.9 0.4 -1.5 -1.1 -2.3 -1.2 -2.4 -1.8
Arm fat mass (left) 0.3 1.3 7.7 -0.3 -0.5 0.3 -0.3 -0.4 -0.8 -0.8 -2.8 -1.9 -0.0 -1.3 -0.8
Number of self-reported non-cancer illnesses 0.7 1.2 2.3 1.4 0.7 1.1 0.3 1.0 -0.9 1.5 -1.5 1.2 0.7 1.0 0.9
Average weekly champagne plus white wine intake 0.9 1.2 3.7 -1.6 -1.3 -0.6 -0.7 -1.0 0.6 -1.3 -0.9 -1.9 -0.4 -1.2 -0.6
Miserableness 2.1 3.6 8.5 -1.3 -0.1 -2.6 -2.1 -1.4 2.8 -0.8 2.9 -0.8 -0.2 -2.3 -2.3
Guilty feelings 0.5 0.8 6.0 -0.0 -0.0 -1.5 -0.4 -0.2 0.6 -0.3 2.4 -0.2 -0.2 -0.7 -0.4
Wears glasses or contact lenses 0.8 0.9 3.9 -1.0 -0.8 -0.5 -0.3 -0.5 -0.5 -0.4 -0.3 -0.9 -1.2 -2.0 -1.5
Ever taken oral contraceptive pill 0.4 0.5 2.3 0.0 0.3 1.5 -0.7 0.1 -1.1 -0.4 -0.9 0.2 -0.7 0.3 -0.0
Hearing aid user 0.6 0.6 2.2 -0.5 1.2 -0.7 -1.5 0.5 0.4 0.0 -0.0 -0.6 1.3 -0.5 -0.6
Mother’s age at death 0.6 0.7 2.1 0.7 0.2 0.5 0.4 -0.1 -1.4 1.4 0.6 1.3 -0.3 1.0 1.0
Financial situation satisfaction 1.6 2.0 4.8 1.2 1.7 1.6 -2.2 1.2 1.6 1.7 -1.1 1.6 1.3 0.2 0.3
Tinnitus: Yes, now most or all of the time 1.1 1.3 4.0 -1.2 -1.6 -1.1 0.6 -1.2 -2.0 -0.8 0.2 -1.3 -1.1 -1.1 -0.6
Commuting to job workplace: Public transport 2.3 2.8 6.6 1.9 1.2 1.4 -1.5 0.4 0.6 2.2 -1.0 2.4 0.1 2.2 2.6
Eye problems/disorders: Glaucoma 0.6 0.8 2.8 0.9 0.2 -0.5 1.3 0.3 -0.1 1.0 0.5 1.7 0.3 1.1 0.8
Medication: Blood pressure 0.3 0.5 1.6 -0.6 -0.9 0.0 0.5 -0.1 -0.7 -0.2 -1.2 0.4 -0.5 -0.7 -1.1
Pain type(s) experienced in last month: Hip pain 1.2 1.5 6.1 0.5 1.5 1.3 -2.5 -0.3 -0.5 1.2 -0.5 1.1 1.5 1.0 1.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 4.3 0.6 -0.4 -0.8 2.1 0.4 0.2 -0.3 1.6 0.5 -0.4 -0.4 -1.0
High cholesterol (Self-reported) 0.3 0.6 1.8 -0.5 -1.0 0.3 1.3 -0.2 0.1 -0.1 -1.4 -0.2 0.1 -1.1 -1.0
Medication: Bendroflumethiazide 0.4 0.6 1.6 -0.5 -1.0 -1.0 -0.3 -0.5 -1.1 0.0 -0.1 0.0 -0.4 -1.3 -1.2
Medication: Paracetamol 0.6 1.0 4.1 1.1 1.2 -0.9 -0.4 0.5 2.0 0.8 0.4 0.5 1.4 -0.5 -0.8
Medication: Lisinopril 0.8 1.0 3.3 -1.0 -0.9 -0.5 0.9 -0.3 -0.8 -1.4 -0.6 -0.9 0.5 -1.5 -1.8
Medication: Atorvastatin 0.1 0.2 0.6 0.0 -0.8 -0.3 0.3 -0.8 -0.5 0.3 -0.4 0.2 -0.4 0.3 -0.1
Illnesses of father: High blood pressure 0.4 0.5 3.6 -0.4 0.3 -0.3 -1.9 -0.4 -0.0 0.4 0.7 0.3 0.2 0.3 1.0
Alcohol drinker status: Never 0.9 1.1 4.7 0.8 1.4 -1.1 0.4 1.2 0.5 0.8 0.3 1.0 2.2 -0.4 -0.9
Ever smoked 0.2 0.3 1.3 0.0 0.7 -0.7 -0.2 0.2 1.2 0.6 0.5 0.3 0.6 0.0 -0.7
Basal metabolic rate 0.5 2.8 7.5 -2.0 -1.3 -1.4 -1.3 -1.3 0.7 -1.5 -0.8 -2.7 -1.2 -2.7 -2.0
Leg fat percentage (left) 0.4 1.4 8.6 0.5 0.5 0.7 -0.0 0.0 -2.0 -0.3 -2.9 -1.0 1.2 -0.3 -0.3
Arm fat-free mass (left) 0.7 3.7 9.0 -2.3 -1.3 -2.2 -1.5 -1.5 1.1 -1.7 -0.3 -2.9 -1.0 -3.0 -2.3
Number of operations (self-reported) 4.2 6.2 15.0 -3.9 -3.0 -1.3 -1.1 -2.7 -0.8 -3.1 0.0 -2.3 -2.6 -3.1 -2.9
Average weekly beer plus cider intake 0.5 0.8 4.5 0.3 -0.8 -0.6 2.1 -0.2 -0.1 0.3 0.9 -0.9 -0.5 0.2 1.1
Irritability 0.5 0.8 2.4 1.1 1.3 -0.5 -1.2 1.4 0.8 0.5 0.3 0.2 1.5 0.0 -0.1
Risk taking 0.2 0.2 0.6 -0.4 -0.5 0.5 0.2 -0.4 0.3 -0.5 -0.8 -0.7 -0.6 0.2 -0.0
Ever had prostate specific antigen (PSA) test 0.7 0.8 3.6 -0.2 0.2 -1.6 -0.6 -1.1 0.9 0.7 -0.2 0.2 -0.0 -1.0 -1.9
Fractured/broken bones in last 5 years 0.4 0.5 3.0 0.4 0.6 0.3 0.4 1.2 1.7 0.6 -0.2 -0.2 0.3 -0.7 0.5
Age started oral contraceptive pill 1.0 1.3 6.2 0.2 -0.3 0.6 2.3 0.3 -2.5 -0.4 -1.1 1.0 0.0 0.9 -0.2
Diastolic blood pressure, automated reading 0.8 2.3 10.4 0.9 0.0 -1.0 2.5 0.9 -1.8 0.0 -3.2 -1.6 1.6 0.5 0.7
Ever depressed for a whole week 0.9 1.1 4.9 0.7 0.8 0.8 -2.2 0.2 0.0 1.4 0.4 1.4 -0.1 1.2 1.1
Unable to work because of sickness or disability 0.9 1.1 4.0 0.7 1.0 0.7 -1.3 1.2 1.4 0.0 -0.6 0.2 -0.1 1.4 2.0
Commuting to job workplace: Cycle 1.0 1.2 4.5 -0.9 -0.5 -1.7 0.2 -0.8 2.1 0.1 1.5 -1.1 -0.9 -0.7 -0.8
Myopia 0.4 0.6 2.2 0.5 0.1 0.8 -1.1 0.3 0.1 0.7 0.9 1.5 -0.4 0.6 0.6
Vascular/heart problems diagnosed by doctor 0.1 0.3 1.1 -0.1 0.2 -0.9 -0.8 -0.4 -0.0 -0.2 1.1 -0.7 -0.4 -0.6 -0.0
Cholesterol lowering medication 0.6 0.9 3.4 -0.8 -0.5 -0.0 0.6 -0.4 -0.6 -0.7 -1.2 -0.3 0.5 -1.9 -1.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.1 -0.9 -0.9 -0.1 1.0 -0.5 -0.3 -0.8 0.1 -0.1 -0.6 -0.1 -0.3
Pain experienced in last month 0.2 0.4 1.9 -1.0 -0.6 0.0 1.4 -1.0 -0.1 0.4 -0.0 0.3 -0.2 -0.0 -0.3
Supplements: Calcium 2.6 2.9 6.1 2.1 2.0 1.6 0.7 2.4 -1.8 1.0 -0.1 2.5 1.9 1.8 0.9
Basal cell carcinoma (self-reported) 0.7 0.8 2.3 -0.9 -0.8 0.1 0.4 -0.7 1.2 -1.0 -1.4 -1.5 -0.5 -0.3 -0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 3.6 -0.1 -0.2 0.2 -0.0 0.0 1.8 -0.2 1.9 1.1 -1.1 0.6 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.4 0.6 -0.1 -1.2 1.0 -1.0 -0.8 0.8 0.2 -0.3 -0.7 0.1 -0.5
Heart disease (siblings) 0.9 1.1 4.8 0.7 -0.8 -0.5 2.2 -0.6 -1.9 0.6 -0.5 0.0 -1.0 1.1 0.1
Alcohol drinker status: Previous 0.6 0.7 1.7 -0.9 -0.7 -0.8 -0.3 -0.8 0.5 -1.1 -0.5 -0.3 -0.8 -1.0 -1.3
Pack years of smoking 0.3 0.5 2.4 -0.0 0.9 0.5 -1.0 0.4 -1.6 -0.8 0.3 0.3 0.4 0.8 0.1
Impedance of whole body 0.9 4.4 10.5 2.6 2.5 2.4 0.9 2.1 0.4 1.9 -0.2 2.6 3.2 2.2 1.8
Leg fat mass (left) 0.4 1.4 6.2 -0.5 -0.2 -0.2 -0.7 -0.5 -1.2 -0.8 -2.5 -1.9 0.4 -1.5 -1.2
Arm predicted mass (left) 0.7 3.6 8.7 -2.4 -1.3 -2.1 -1.3 -1.6 0.9 -1.7 -0.4 -2.8 -1.1 -2.9 -2.3