Hub : Genes

FAM83H

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2970 0.0480 0.0e+00 0.131 0.228 0.282 0.272 0.278 1.2e-15 2.4e-27 1.8e-34 4.3e-33 5.8e-34
2 GTEx Brain Cerebellar Hemisphere 0.3130 0.1160 6.2e-03 -0.010 NA 0.041 NA 0.061 6.8e-01 NA 3.2e-02 NA 1.1e-02
3 GTEx Brain Cerebellum 0.2810 0.0850 1.0e-04 0.260 NA 0.155 NA 0.062 2.6e-08 NA 2.4e-05 NA 6.7e-03
4 GTEx Brain Cortex 0.3000 0.0990 1.9e-03 0.013 NA 0.032 NA 0.021 1.4e-01 NA 4.6e-02 NA 8.6e-02
5 METSIM Adipose 0.0967 0.0311 8.0e-06 0.012 0.038 0.010 0.036 0.014 5.1e-03 2.0e-06 9.3e-03 3.3e-06 2.7e-03
6 ROSMAP Brain Pre-frontal Cortex 0.2842 0.0553 2.5e-11 0.109 0.107 0.133 0.130 0.134 6.7e-14 1.2e-13 1.0e-16 2.0e-16 6.6e-17
7 YFS Blood 0.0314 0.0109 6.0e-05 0.007 0.013 0.010 0.012 0.009 1.4e-03 3.9e-05 3.0e-04 4.0e-05 4.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.1 0.2 0.5 0.7 0.2 0.5 0.0 0.1 0.7 -0.3
Bipolar Disorder or Schizophrenia 2.0 5.0 15.0 0.0 1.1 3.9 2.8 -0.6 2.8 -1.4
Depressed Affect (Nagel 2018) 0.5 1.0 2.1 -1.1 -1.4 -0.5 -0.5 0.8 -0.5 -1.4
Depression (Nagel 2018) 0.4 0.7 3.5 -0.7 -0.6 0.3 0.0 1.9 0.2 0.2
Intelligence (Savage-Jansen 2018) 0.6 1.8 3.9 -1.3 -0.9 -2.0 -1.2 -1.4 -1.5 -0.7
Neuroticism (Nagel 2018) 0.4 0.9 2.2 -1.0 -1.3 0.2 -0.5 1.5 -0.0 -0.9
Schizophrenia (2018) 5.1 10.6 26.6 5.2 1.3 4.4 3.8 -0.7 3.1 -1.3
Schizophrenia vs Biploar Disorder 0.3 0.4 1.6 0.0 -1.3 -0.2 0.0 -0.7 -0.3 0.6
Worry (Nagel 2018) 0.7 1.6 4.3 1.3 0.3 2.1 1.0 -0.0 1.5 -1.3
Alzheimer’s Disease (in mother) 0.3 0.3 0.6 -0.4 0.8 -0.6 -0.3 0.7 -0.5 -0.1
Alzheimer’s Disease (in father) 2.8 3.0 6.3 0.4 -1.8 -1.4 -1.6 -1.6 -2.1 -2.5
Alzheimer’s Disease (including proxy) 0.8 1.1 3.3 -0.2 0.1 -1.4 -0.8 -0.7 -1.8 -1.2
Crohns Disease (2017) 0.8 1.7 5.9 0.6 0.4 0.3 1.6 1.5 0.6 2.4
Irritable Bowel Disease (IBD) 0.5 1.1 3.7 1.0 -0.1 -0.1 1.4 1.2 0.3 1.9
Ulcerative Colitis (UC) 0.2 0.4 0.9 0.9 -0.3 -0.7 0.6 0.6 -0.0 1.0
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.3 0.5 1.4 -0.3 -1.2 0.3 0.4 -0.7 0.7 -0.8
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.0 -0.6 -0.0 -1.4 -0.9 -0.9 -1.3 -1.1
Breast Cancer 1.5 3.5 8.2 -2.9 -0.1 -2.2 -2.5 1.1 -2.0 -0.1
Ovarian Cancer 0.9 1.1 2.8 -1.1 -1.7 -0.4 -0.4 -0.8 -1.1 -1.4
Prostate Cancer 8.0 11.2 22.6 -4.5 -2.9 -4.8 -3.1 -0.1 -4.1 0.8
Age at First Birth 0.1 0.2 0.4 0.2 0.4 -0.2 -0.3 0.5 -0.7 -0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.1 2.8 5.7 -2.4 -0.5 -1.7 -2.0 0.2 -2.1 -1.6
Coronary Artery Disease (CAD) 0.0 0.0 0.2 0.0 0.3 0.0 0.4 -0.2 0.0 0.1
Crohns Disease (2012) 1.1 1.8 5.4 -1.2 -1.1 -1.7 -0.2 1.2 -0.6 2.3
Mean Putamen Volume 1.5 1.7 3.3 1.1 1.8 1.8 1.4 -0.1 1.4 0.1
Fasting Glucose 0.6 0.8 2.0 -0.2 -0.7 1.2 0.1 -1.1 1.4 -0.5
HbA1C 0.1 0.1 0.2 -0.3 0.2 -0.4 0.3 0.3 0.2 0.5
HDL Cholesterol 0.6 1.0 1.8 1.1 1.3 1.3 0.7 -0.9 0.9 -0.2
LDL Cholesterol 1.1 1.8 4.5 0.3 0.1 1.5 0.4 -1.8 1.6 -2.1
Lupus 1.0 1.5 3.5 -1.4 -1.9 -1.2 -1.4 -1.0 -0.9 -0.1
Neuroticism (2016) 1.7 2.4 6.2 -1.9 -0.1 -1.5 -2.5 1.0 -1.6 -1.0
Primary Biliary Cirrhosis 1.2 1.7 5.4 0.8 -0.7 1.2 2.3 0.4 1.1 1.6
Rheumatoid Arthritis 0.4 0.5 1.2 0.8 -0.1 1.1 0.8 0.4 1.1 0.4
Schizophrenia (2014) 5.5 12.1 25.3 4.8 1.4 5.0 4.1 -1.1 3.9 -1.2
Triglycerides 0.2 0.3 1.0 -0.3 -1.0 0.5 0.0 0.8 0.6 0.1
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.4 0.0 0.1 -0.3 -0.7 -0.2 -0.4 -0.4
Ulcerative Colitis 0.3 0.4 2.0 0.6 -1.4 -0.3 -0.3 0.6 -0.2 0.2
Blood Eosinophil Count 0.4 3.4 5.9 -2.1 -2.0 -2.4 -1.7 0.4 -2.3 0.7
Blood Platelet Count 0.1 1.6 6.1 1.6 0.2 -1.3 -0.6 -0.6 -0.4 -2.5
Blood Red Count 0.2 1.6 4.9 -0.4 -0.5 0.7 -0.6 -2.2 -0.2 -2.2
Blood White Count 0.2 1.3 4.9 0.3 -1.4 -0.5 -1.2 2.2 -0.4 -0.2
Heel T-Score 0.5 3.9 11.3 1.1 3.4 2.2 2.2 -0.0 2.2 -0.2
BMI 1.3 7.6 16.5 -3.6 -2.1 -4.1 -2.8 1.8 -2.9 -0.2
Height 1.7 32.7 77.4 -8.8 -3.5 -6.7 -7.2 0.8 -6.1 2.1
Waist Hip Ratio (WHR) 0.6 2.7 7.3 2.7 -0.3 2.4 1.2 -1.3 1.5 -0.6
Systolic Blood Pressure 0.3 1.7 6.8 -1.1 2.6 0.1 -1.2 -0.9 -0.2 -1.2
Smoking Status 0.4 1.0 4.1 -0.5 -2.0 -0.2 0.8 -0.8 -0.9 -0.3
Allergy or Eczema 0.1 0.4 0.7 0.8 0.3 0.5 0.7 -0.4 0.8 0.2
Cardiovascular Disease 0.7 2.2 3.1 -1.5 1.2 -1.7 -0.9 -1.6 -1.6 -1.8
Hypothyroidism (self reported) 0.4 1.0 3.0 -0.2 -0.3 -1.1 0.1 1.7 -1.0 1.4
Respiratory disease 2.2 4.9 9.9 -2.3 -1.3 -2.8 -3.1 0.2 -2.9 -1.3
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.5 -0.1 -0.3 0.3 -0.4 -0.7 0.4 -0.2
Lung FEV1/FVC ratio 0.3 1.5 4.0 0.8 0.4 1.3 -0.5 -2.0 -0.2 -2.0
Lung FVC 0.2 1.1 2.6 1.6 0.8 1.0 1.2 0.0 0.2 -1.5
Neuroticism 0.3 0.8 1.6 -1.3 -0.7 0.8 0.1 1.1 1.1 -0.4
Chronotype (morning person) 0.3 0.7 2.8 -0.9 -0.3 -0.9 0.1 -1.7 -0.2 0.3
Hair Pigment 0.1 3.8 7.7 -1.2 -2.8 -2.7 -1.3 -1.6 -2.5 -0.4
Tanning 0.3 4.2 9.6 -2.3 -1.0 -2.6 -2.4 0.8 -3.1 -0.6
Hand grip strength (left) 2.4 6.4 12.2 -2.8 -1.9 -2.6 -3.3 -1.2 -3.5 -1.6
Number of treatments/medications taken 0.5 0.9 2.1 -0.8 0.4 -1.5 -1.2 0.4 -1.4 -0.6
Average weekly spirits intake 0.3 0.4 0.8 -0.8 0.4 -0.3 -0.9 0.7 0.2 0.6
Sensitivity / hurt feelings 1.9 3.3 9.4 -3.0 0.3 -0.9 -1.0 3.1 0.5 1.5
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.3 -0.4 -0.4 -0.5 -0.2 1.1 -0.6 0.4
Hearing difficulty/problems: Yes 1.2 1.8 4.7 -1.8 -0.4 -1.1 -2.2 1.6 -0.3 0.5
Relative age of first facial hair 1.8 3.7 9.8 2.2 0.1 3.1 2.4 -0.1 2.2 0.9
Other serious medical condition/disability diagnosed by doctor 3.5 4.5 9.0 3.0 1.1 2.2 2.4 1.3 2.9 1.0
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.7 0.8 -0.1 -0.1 -0.1 -0.1 -0.1 -0.5
Ever had hysterectomy (womb removed) 0.7 0.8 2.8 1.7 0.4 1.2 0.9 -0.4 0.6 -0.4
Systolic blood pressure, automated reading 0.4 1.1 3.9 -2.0 1.0 -0.6 -1.2 -0.8 -0.5 -0.4
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.4 -1.1 -0.3 -1.5 -0.7 -0.2 -0.9 -0.2
Angina 1.4 1.8 6.1 -0.8 -0.4 -2.5 -1.7 0.0 -1.6 0.1
Medication for hormone replacement therapy 0.7 0.8 2.2 -0.4 0.7 -1.0 -0.5 1.0 -1.5 0.5
Vitamin and mineral supplements 0.2 0.2 0.6 -0.2 -0.0 0.7 0.5 -0.5 0.6 -0.1
Supplements: Zinc 0.3 0.3 1.0 -1.0 -0.1 -0.3 -0.4 0.8 -0.5 0.4
Medication: Co-codamol 3.6 4.2 9.4 2.9 0.5 2.4 2.0 1.1 3.1 0.6
Medication: Metformin 0.2 0.2 0.6 -0.2 0.3 0.2 -0.7 -0.8 0.1 -0.6
Diabetes (father) 2.0 2.4 6.3 2.5 0.5 2.0 1.5 0.7 1.8 0.7
Diabetes (mother) 0.8 1.0 2.5 1.4 -0.3 1.0 1.1 -0.5 1.6 0.4
Severe depression (siblings) 0.6 0.7 1.7 -0.2 -0.9 -0.2 1.0 0.5 0.8 1.3
Pack years adult smoking proportion 0.5 0.7 4.0 0.5 -2.0 -0.4 -0.4 0.0 0.2 0.4
Impedance of leg (right) 0.7 3.4 6.7 2.6 -0.3 2.0 1.9 1.1 1.6 2.3
Leg fat-free mass (left) 2.0 10.7 27.1 -5.2 -1.5 -4.4 -4.0 -0.0 -3.2 -0.1
Trunk fat percentage 1.7 6.8 11.7 -3.1 -2.9 -3.4 -3.2 1.2 -2.3 0.7
Hand grip strength (right) 1.4 3.9 9.5 -1.7 -1.2 -2.7 -1.8 -1.2 -3.1 -1.0
Townsend deprivation index at recruitment 1.1 1.6 3.2 1.2 -0.7 0.9 1.7 -0.5 1.8 1.4
Current tobacco smoking 0.3 0.6 1.9 -0.1 -0.5 0.6 1.4 -1.0 0.5 -0.4
Average weekly fortified wine intake 0.4 0.5 1.3 -0.8 0.1 -1.1 -0.0 -1.1 -0.6 -0.2
Maternal smoking around birth 0.1 0.2 0.5 0.5 -0.7 0.2 -0.3 -0.4 0.0 0.3
Fed-up feelings 0.3 0.5 2.5 -0.7 -1.6 0.1 0.2 0.3 -0.3 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.2 -0.7 -0.5 -0.6 -0.4 1.1 -0.9 0.5
Relative age voice broke 0.4 0.6 2.1 1.5 -0.5 1.0 0.5 -0.5 0.4 -0.0
Taking other prescription medications 0.6 1.0 2.9 -0.8 0.1 -1.2 -1.2 1.7 -0.5 -0.6
Age when periods started (menarche) 0.2 0.5 1.9 0.8 -0.0 0.7 0.2 -0.2 0.4 1.4
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.8 0.7 -0.5 0.8 0.9 1.4 1.6 1.7
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.0 8.3 1.3 2.4 2.6 2.4 -0.1 2.9 0.4
Tinnitus: Yes, but not now, but have in the past 1.9 2.1 4.3 -1.5 -0.5 -1.2 -2.1 -0.8 -1.9 -1.4
Qualifications: CSEs or equivalent 0.6 0.8 1.7 0.9 1.0 0.3 1.3 0.7 1.1 0.7
Serious illness, injury or assault to yourself 1.0 1.2 4.0 -1.2 -1.1 -2.0 -1.0 0.3 -1.0 0.1
High blood pressure 0.7 1.9 3.7 -1.4 -0.1 -1.9 -1.0 -1.0 -1.7 -1.8
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.1 0.7 1.0 0.7 0.8 0.6 0.7 0.8
Multivitamins +/- minerals 0.4 0.5 1.1 -0.8 -0.3 -0.9 -1.0 -0.3 -1.0 0.4
Stomach or abdominal pain in last month 1.9 2.4 5.5 2.3 0.4 2.3 1.5 -0.5 1.8 -0.2
Supplements: Glucosamine 0.8 1.0 2.6 -1.6 -1.6 -1.0 -0.8 0.1 -0.6 -0.2
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.6 0.8 -0.1 0.4 0.3 0.3 0.3 0.3
Medication: Atenolol 2.3 2.9 5.3 -1.1 0.6 -1.6 -1.4 -2.1 -2.2 -2.3
Medication: Levothyroxine sodium 1.0 1.7 4.2 -0.6 -1.5 -1.4 -0.1 2.0 -0.8 1.7
Sitting height 2.0 14.4 39.6 -6.3 -3.1 -3.5 -4.4 -2.1 -3.9 -0.4
Chronic bronchitis/emphysema (father) 1.2 1.4 2.8 1.4 1.7 0.7 1.3 1.6 0.7 0.4
High blood pressure (mother) 0.8 1.1 3.8 -1.2 -2.0 -1.2 -0.8 -0.2 -0.8 -0.0
Body mass index (BMI) 1.0 4.3 12.2 -2.4 -0.9 -3.5 -2.0 0.9 -2.4 -0.5
Impedance of leg (left) 0.7 3.3 7.8 2.8 -0.5 2.1 2.0 0.8 1.1 2.1
Leg predicted mass (left) 2.0 10.8 27.3 -5.2 -1.4 -4.4 -4.0 0.1 -3.2 -0.1
Trunk fat mass 2.6 11.1 20.1 -4.4 -3.0 -4.5 -4.0 1.4 -3.3 0.9
Waist circumference 1.5 5.6 13.8 -2.7 -1.7 -3.7 -2.6 0.2 -2.9 -0.4
Number of incorrect matches in round 0.2 0.3 1.1 -0.5 -1.0 -0.3 0.4 0.7 -0.5 0.4
Past tobacco smoking 1.1 2.0 9.1 0.9 3.0 1.3 0.1 -0.1 1.4 -0.5
Alcohol usually taken with meals 0.5 0.8 2.2 -1.0 0.0 -1.5 -0.5 0.3 -1.4 0.2
Nervous feelings 0.8 1.4 2.3 0.9 0.9 1.5 0.7 -1.1 1.5 -1.4
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.6 0.6 -0.7 0.2 0.1 0.3 0.0 -0.2
Hearing difficulty/problems with background noise 2.2 3.6 8.7 -2.5 -0.5 -2.2 -3.0 -0.3 -1.9 -1.1
Hair/balding pattern: Pattern 2 1.1 1.4 3.9 -0.2 -0.5 -1.2 -1.1 2.0 -1.0 1.4
Had menopause 0.6 0.7 2.8 -0.8 -1.7 -0.9 -0.2 -0.3 -0.8 0.3
Had other major operations 0.8 1.0 5.1 0.3 -2.2 -0.0 -0.2 -0.7 -0.9 -0.8
Forced vital capacity (FVC) 0.2 0.6 1.6 -1.1 -0.3 -0.6 -0.7 -0.6 -1.3 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.5 6.4 1.1 2.1 2.5 2.4 -0.8 2.4 -0.6
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.7 -0.0 0.0 0.3 -0.1 -0.8 0.0 -0.8
Qualifications: None of the above 0.4 0.9 3.0 -0.4 -1.7 -1.3 -0.1 -1.1 -0.9 -0.1
Financial difficulties in last 2 years 0.2 0.3 0.9 -0.5 -0.7 -0.4 -0.6 0.9 -0.3 -0.1
Mouth/teeth dental problems 0.3 0.5 2.4 -0.2 -1.6 -0.2 -0.3 0.1 -0.3 0.9
Heart attack 2.0 2.5 5.6 -2.1 -0.4 -2.4 -1.6 -0.3 -2.2 -0.2
Allergy 0.4 0.9 1.8 0.7 -0.4 1.3 1.3 -0.6 1.4 -0.1
Pain all over the body in last month 0.7 0.8 2.8 0.5 -1.2 -0.4 -0.1 1.7 0.3 0.9
Diabetes (self-reported) 0.1 0.1 0.4 0.2 -0.2 0.2 0.4 0.1 0.7 0.6
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.8 0.7 0.6 0.6 0.5 0.7 0.4 1.4
Medication: Ramipril 0.3 0.3 0.9 1.0 -0.5 -0.6 0.4 -0.6 -0.3 0.1
Medication: Simvastatin 0.5 0.7 3.4 0.4 -0.3 -0.4 -0.4 -0.8 -0.3 -1.8
Fluid intelligence score 0.7 1.4 3.9 -0.0 -1.3 -0.8 -0.9 -1.4 -0.6 -2.0
Illnesses of siblings 1.5 2.1 4.8 1.4 0.7 2.2 1.8 0.3 1.8 0.9
Neuroticism score 0.3 0.6 1.6 -1.3 -0.5 0.4 -0.6 0.9 0.5 -0.9
Weight 2.6 12.8 25.2 -5.0 -2.5 -5.0 -4.1 0.6 -4.0 0.3
Impedance of arm (right) 0.5 2.2 4.8 1.4 -0.5 2.2 0.7 0.3 2.0 2.0
Arm fat percentage (right) 1.1 4.3 10.4 -2.6 -1.5 -3.2 -2.3 1.5 -1.8 0.4
Trunk fat-free mass 2.1 12.0 29.1 -5.4 -1.0 -4.8 -3.8 -0.0 -4.2 -0.0
Hip circumference 2.9 12.3 30.0 -4.8 -2.0 -5.5 -3.7 0.3 -4.0 -0.0
Time employed in main current job 0.2 0.3 0.6 -0.5 0.8 0.3 -0.3 0.5 0.1 0.8
Alcohol intake versus 10 years previously 1.0 1.5 3.2 1.5 -1.5 0.6 1.1 1.8 0.7 1.0
Father’s age at death 0.2 0.2 1.0 -0.1 -1.0 0.1 -0.0 0.4 0.0 0.5
Worrier / anxious feelings 0.7 1.4 5.2 0.5 0.1 1.7 0.5 -0.7 0.6 -2.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.5 -1.2 -0.3 -0.8 -1.0 0.5 -0.0 -0.8
Falls in the last year 0.2 0.3 0.9 -0.1 0.6 0.1 0.9 0.0 1.0 -0.4
Hair/balding pattern: Pattern 3 0.5 0.7 3.2 -0.8 0.3 0.1 -0.6 -0.8 -0.0 -1.8
Number of live births 6.2 8.8 17.3 4.2 2.3 3.3 3.2 0.8 4.1 0.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.3 -0.5 0.6 -0.1 -0.8 -1.1 -1.1 -0.9
Pulse rate 0.2 0.4 1.0 1.0 0.7 0.0 0.5 0.6 0.8 0.4
Happiness 0.3 0.4 1.0 -0.3 -0.5 -0.3 -0.7 1.0 0.3 0.7
Noisy workplace 0.2 0.3 1.0 -1.0 0.0 -0.6 0.1 -0.7 -0.1 -0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.7 0.2 -0.7 -0.3 -0.1 -0.6 -0.6 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.4 -1.2 -0.5 -0.4 -0.2 -0.1 -0.3 -0.3
Mouth/teeth dental problems: Dentures 0.5 0.8 2.0 -1.1 0.6 -1.4 -0.9 1.0 -0.7 0.1
Asthma 2.4 4.7 11.1 -1.8 -0.5 -2.9 -3.1 0.0 -3.3 -1.0
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 4.2 2.0 1.6 1.5 1.0 -0.5 1.1 -0.8
Medication: Cholesterol lowering 2.1 3.2 8.3 -1.9 -0.5 -2.9 -2.2 0.3 -2.3 -0.7
Depression (self-reported) 1.8 2.2 4.9 2.0 0.6 2.2 0.9 0.1 2.0 -0.8
Medication: Lansoprazole 1.2 1.4 3.0 -1.5 -1.4 -1.3 -0.5 1.7 0.1 0.8
Prospective memory result 0.3 0.3 1.3 -0.3 -0.6 -0.0 0.2 0.5 -0.5 1.2
Lung cancer (father) 2.3 2.7 6.3 -1.6 -2.5 -2.1 -1.9 -0.7 -1.2 -0.6
Illnesses of mother 0.4 0.5 1.2 1.0 1.1 0.9 0.3 0.2 0.3 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.6 0.3 1.2 0.7 -0.3 -0.8 -0.4 -0.9
Pulse wave Arterial Stiffness index 0.7 0.8 1.3 -1.0 -0.5 -1.0 -0.4 -0.9 -1.1 -1.1
Impedance of arm (left) 0.6 2.7 6.8 1.5 -1.5 2.6 0.7 -0.1 2.2 1.5
Arm fat mass (right) 1.7 7.1 16.6 -3.5 -1.8 -4.1 -2.8 1.4 -2.8 0.5
Trunk predicted mass 2.2 12.3 29.7 -5.5 -1.0 -4.9 -3.8 0.1 -4.2 0.1
Standing height 1.5 15.2 38.3 -6.2 -3.5 -3.9 -4.8 -0.7 -3.9 1.6
Length of working week for main job 1.1 1.2 2.6 1.6 -0.6 1.1 1.2 1.4 0.9 0.5
Exposure to tobacco smoke at home 0.1 0.1 0.2 0.3 -0.1 -0.4 0.2 0.4 -0.2 -0.1
Breastfed as a baby 1.3 1.7 3.0 -1.6 -1.7 -1.5 -1.2 0.5 -1.1 -0.8
Tense / ‘highly strung’ 0.3 0.6 2.2 -1.2 0.2 0.2 -0.4 -0.3 -0.3 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.9 0.4 -1.4 0.7 -0.0 0.5 0.9 -1.1
Hair/balding pattern: Pattern 4 0.6 1.5 4.1 -0.5 -0.5 -2.0 -1.6 0.3 -1.9 -0.2
Birth weight of first child 1.5 2.8 6.0 -2.3 0.3 -1.8 -2.2 -0.2 -2.5 -0.3
Peak expiratory flow (PEF) 0.4 1.0 3.0 0.1 1.2 1.1 -0.0 -1.7 0.7 -1.0
Pulse wave reflection index 1.2 1.5 4.1 -0.1 -1.6 -0.6 -0.1 -2.0 -0.7 -1.8
Ever highly irritable/argumentative for 2 days 1.6 1.9 3.6 -1.7 -1.3 -1.7 -1.9 -0.1 -1.4 -0.3
Loud music exposure frequency 1.9 2.0 4.9 -2.2 -0.8 -1.8 -1.8 0.2 -1.4 -0.1
Qualifications: O levels/GCSEs or equivalent 2.2 3.6 9.1 3.0 0.7 2.5 2.4 -0.2 1.8 0.1
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 0.2 0.0 0.0 0.6 0.3 -0.1 0.4
Blood clot in the leg (DVT) 0.9 1.2 3.1 -1.0 -0.4 0.6 -0.3 1.7 0.9 1.8
Medication: Paracetamol 0.0 0.1 0.2 -0.3 0.2 0.0 0.4 -0.2 0.4 0.0
Headache pain in last month 0.1 0.2 0.5 0.7 0.4 0.3 0.5 -0.5 0.5 -0.1
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 5.7 2.0 1.0 2.4 2.4 -0.0 2.0 1.4
Glaucoma (self-reported) 1.1 1.3 4.6 -0.8 -0.9 -0.4 -0.3 1.4 0.8 2.2
Gout (self-reported) 1.1 1.5 4.2 -1.2 -0.7 -2.0 -0.9 1.3 -1.4 0.4
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.8 -0.3 -0.9 -1.3 -0.5 1.1 -1.3 0.8
Medication: Amlodipine 1.3 1.8 3.9 -1.7 -0.4 -1.3 -2.0 -0.5 -1.7 -0.8
Medication: Ventolin 100micrograms inhaler 4.1 5.2 11.1 -2.5 -1.0 -2.8 -3.2 0.3 -3.3 -0.2
Birth weight 6.0 12.9 20.3 -2.5 -4.5 -4.3 -4.1 -2.0 -4.2 -2.6
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.5 -0.6 -0.1 -0.9 -0.0 1.0 -0.9 1.6
High blood pressure (siblings) 1.9 2.7 5.2 -1.6 -0.7 -2.0 -1.6 -1.0 -2.3 -1.8
Forced vital capacity (FVC), Best measure 0.1 0.4 1.2 -0.7 0.5 -0.5 -0.6 -0.5 -1.1 -0.4
Body fat percentage 1.5 5.8 11.2 -2.7 -2.7 -3.3 -2.7 1.6 -2.1 0.8
Leg fat percentage (right) 1.1 4.2 10.4 -2.2 -1.8 -3.2 -1.9 1.9 -1.7 0.8
Arm fat-free mass (right) 2.2 11.5 23.4 -4.8 -1.8 -4.7 -3.8 -0.2 -4.1 -0.3
Exposure to tobacco smoke outside home 0.9 1.2 3.9 2.0 -0.7 1.3 -0.0 -0.8 -0.2 -1.3
Comparative body size at age 10 0.5 1.4 4.3 -1.0 0.5 -2.1 -0.6 0.1 -2.0 -0.1
Number of full brothers 2.4 3.0 6.3 2.5 -1.5 1.6 2.0 -2.1 1.1 -0.3
Worry too long after embarrassment 0.7 1.2 3.0 -0.8 -1.6 -0.4 -1.7 1.5 -0.1 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 3.2 1.7 -0.2 1.1 1.8 1.5 1.3 0.9
Wheeze or whistling in the chest in last year 1.7 3.1 6.5 -1.3 -1.9 -2.4 -1.8 -0.6 -2.6 -0.1
Number of children fathered 1.4 1.6 4.1 -1.4 -0.3 -2.0 -1.5 0.2 -1.2 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 1.7 -1.2 -0.5 -1.3 -1.2 1.0 -0.8 0.3
Age at first live birth 0.8 1.4 4.0 -2.0 -0.8 -1.3 -0.9 -0.3 -1.4 -1.0
Pulse wave peak to peak time 0.5 0.6 1.6 0.7 0.1 0.8 0.1 0.8 1.0 1.3
Health satisfaction 0.7 0.9 4.8 0.8 2.2 -0.0 0.0 -0.5 -0.3 -0.9
Shortness of breath walking on level ground 0.1 0.1 0.5 -0.5 0.3 -0.7 -0.1 0.4 -0.2 0.1
Qualifications: College or University degree 0.3 1.0 4.1 2.0 0.4 1.4 0.8 -0.1 0.6 0.3
Eye problems/disorders: None of the above 0.2 0.2 0.8 0.4 -0.3 -0.1 0.0 -0.5 -0.9 -0.5
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.1 1.0 1.5 1.1 1.4 -0.1 0.4 -1.2
Emphysema/chronic bronchitis 1.6 1.8 5.0 -0.6 2.2 -1.6 -1.4 -0.2 -1.6 -0.6
Medication for pain relief, constipation, heartburn 0.2 0.3 0.8 -0.9 -0.3 -0.3 -0.1 0.8 -0.7 0.2
Neck or shoulder pain in last month 0.5 0.7 1.6 -0.1 1.2 -0.5 -0.4 0.1 -1.0 -1.3
Medication: Blood pressure 1.7 3.0 6.7 -2.2 -0.4 -1.4 -2.6 -0.6 -1.4 -2.1
Angina (self-reported) 1.4 1.9 6.1 -0.9 -0.6 -2.5 -1.8 0.0 -1.7 0.1
Migraine (self-reported) 0.5 0.6 1.2 1.1 1.0 -0.4 -1.0 0.9 -0.1 -0.1
Medication: Ibuprofen 0.6 0.7 1.7 1.2 1.3 0.9 0.3 0.0 0.7 -0.4
Medication: Allopurinol 0.8 1.1 2.5 -1.6 -1.0 -1.2 -1.0 1.2 -0.6 0.4
Medication: Omeprazole 0.2 0.3 1.2 1.1 0.5 0.2 -0.1 -0.5 -0.1 -0.4
Medication: Seretide 50 evohaler 0.6 0.7 2.0 -0.1 0.0 -0.9 -1.4 -0.6 -1.0 -0.7
Mean time to correctly identify matches 0.6 1.1 3.1 -1.7 -1.8 -0.8 -0.5 -0.4 -0.6 -0.8
Heart disease (mother) 0.9 1.0 1.7 -0.2 -1.2 -0.8 -1.3 -1.1 -0.9 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 2.7 1.2 0.6 1.2 -0.1 -1.6 0.5 -1.5
Whole body fat mass 2.3 9.5 18.7 -4.0 -2.6 -4.3 -3.5 1.6 -3.1 0.7
Leg fat mass (right) 1.9 7.3 17.3 -3.5 -1.8 -4.2 -2.8 1.5 -2.8 0.6
Arm predicted mass (right) 2.2 11.1 23.6 -4.9 -1.4 -4.8 -3.6 -0.0 -4.1 0.0
Pulse rate, automated reading 0.4 1.2 3.2 1.1 0.8 1.4 -0.0 1.1 1.8 -0.2
Alcohol intake frequency. 0.2 0.5 1.2 0.9 -0.1 0.2 0.9 0.1 1.1 0.8
Comparative height size at age 10 2.8 15.5 31.1 -5.6 -3.5 -4.2 -4.9 -0.7 -4.7 1.2
Number of full sisters 0.7 0.9 2.8 -0.9 -0.0 -1.0 0.5 0.9 -0.6 1.7
Suffer from ‘nerves’ 0.5 0.8 1.6 -1.3 -0.6 -1.0 -1.0 0.4 -0.8 -1.0
Overall health rating 1.2 2.6 5.3 2.3 1.5 1.7 1.7 0.5 2.2 -0.1
Chest pain or discomfort 0.3 0.5 1.2 1.1 -0.7 -0.3 0.1 -0.6 -0.5 -0.9
Had major operations 0.2 0.2 0.4 -0.5 -0.1 -0.5 -0.5 0.4 -0.5 0.6
Age at last live birth 0.1 0.1 0.7 -0.4 -0.8 0.1 0.3 0.0 0.2 0.2
Family relationship satisfaction 0.6 0.7 2.2 0.3 -0.1 -0.0 -0.2 1.5 1.0 1.3
Leg pain on walking 0.3 0.4 1.5 -0.3 -0.6 -0.7 -0.7 1.2 -0.0 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.9 -1.2 1.7 -0.3 -0.6 1.6 -0.2 0.3
Commuting to job workplace: Car/motor vehicle 0.5 0.5 2.7 -0.4 0.4 -1.6 -0.5 0.2 -0.7 0.0
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.4 0.5 -0.2 0.4 -0.6 -0.2 -0.5 -0.3
Medication: Aspirin 1.4 1.9 3.9 -1.2 0.0 -2.0 -1.9 -0.7 -1.8 -0.7
Supplements: Vitamin C 1.1 1.3 2.8 0.3 -1.1 -1.3 -1.1 -0.4 -1.4 -1.7
Knee pain experienced in last month 0.8 1.3 3.9 -0.3 0.8 -0.7 -1.1 -0.7 -1.5 -2.0
Hypertension (Self-reported) 0.7 2.0 5.3 -1.3 0.6 -1.4 -0.9 -1.3 -1.3 -2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.2 -0.2 0.1 -0.2 1.1 0.6 -0.1 0.6
Illnesses of father: Heart disease 0.8 1.0 4.4 0.2 -0.5 -0.6 -0.7 -1.2 -0.5 -2.1
Illnesses of siblings: Diabetes 0.6 0.7 1.4 -1.1 -1.2 -0.4 -1.1 0.6 -0.6 0.1
Smoking status: Previous 1.1 1.7 5.6 -0.9 -2.4 -1.5 -0.5 0.3 -1.5 0.7
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.7 6.1 -2.4 -2.5 -1.2 -1.9 -0.6 -0.7 1.1
Whole body fat-free mass 2.1 11.9 29.1 -5.4 -1.2 -4.7 -3.9 -0.1 -3.9 -0.1
Leg fat-free mass (right) 1.8 9.8 24.4 -4.9 -1.3 -4.1 -3.9 -0.4 -3.3 -0.3
Arm fat percentage (left) 1.1 4.5 9.4 -2.6 -2.1 -3.1 -2.4 1.3 -1.8 0.1
Average weekly red wine intake 0.4 0.5 1.2 -0.1 -0.4 -0.9 0.4 -0.6 -1.1 -0.9
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.8 -1.5 -1.3 -0.7 -1.7 -0.4 -1.2 -0.7
Mood swings 0.3 0.6 1.3 -0.4 -0.4 -0.7 -0.6 0.7 -1.1 -1.0
Loneliness, isolation 0.6 0.9 2.3 -1.5 0.3 -0.1 -1.2 0.4 -0.0 -1.5
Long-standing illness, disability or infirmity 0.6 0.9 2.1 1.2 1.4 0.4 0.6 0.9 1.1 0.4
Ever had bowel cancer screening 0.4 0.4 1.5 -1.2 0.7 0.3 -0.4 0.2 -0.0 -0.9
Diabetes diagnosed by doctor 0.1 0.2 0.5 -0.2 0.0 0.5 0.2 0.1 0.7 0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.6 1.5 1.2 1.6 0.3 -0.5 0.5 -1.3
Friendships satisfaction 0.3 0.4 1.4 -0.5 -0.4 -0.2 -1.2 -0.5 -0.3 -0.6
Qualifications: nursing, teaching 0.0 0.1 0.2 0.4 0.3 0.2 0.1 -0.4 0.2 0.1
Commuting to job workplace: Walk 3.2 3.4 7.5 2.0 1.3 2.7 2.0 -1.2 2.3 -0.3
Eye problems/disorders: Cataract 1.8 2.0 3.0 1.7 1.0 1.1 1.5 1.0 1.7 1.7
Mouth/teeth dental problems: Mouth ulcers 1.9 3.0 11.5 0.0 0.8 1.6 0.2 -3.4 1.5 -2.0
Medication for cholesterol 0.7 1.0 3.7 -0.1 -1.9 0.4 -0.6 0.6 -0.0 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.6 3.1 6.5 2.5 1.4 2.5 0.8 -0.5 2.4 -0.5
Back pain experienced in last month 0.6 0.9 3.0 0.8 1.7 -0.3 -0.2 1.1 -0.4 -0.9
Mineral and other dietary supplements 0.3 0.5 1.9 1.4 0.1 0.7 0.8 0.0 0.5 -0.1
Breast cancer (self-reported) 2.4 2.9 9.0 3.0 -0.3 1.8 2.0 -1.4 1.5 -0.1
Asthma (self-reported) 2.9 5.8 13.7 -2.1 -0.8 -3.3 -3.2 0.3 -3.7 -0.7
Osteoporosis (self-reported) 0.5 0.6 1.3 0.7 1.1 0.2 0.8 0.8 0.2 0.9
Osteoarthritis (self-reported) 0.6 0.8 1.9 0.4 -0.8 -1.4 -0.5 0.8 -0.6 -1.4
Medication: Aspirin 2.8 3.7 7.4 -2.1 -1.0 -2.7 -2.5 -0.4 -2.5 -0.6
Medication: Gliclazide 0.7 0.8 1.8 -1.0 -1.2 -0.8 -1.3 0.3 -0.4 0.6
Illnesses of father: None of the above (group 1) 1.2 1.4 3.1 1.2 -0.2 1.5 1.7 -0.1 1.5 1.0
Smoking status: Current 0.4 0.7 1.7 -0.1 -0.9 0.4 1.1 -1.3 -0.1 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.6 1.2 1.6 1.3 0.5 -0.8 0.4 -0.6
Whole body water mass 2.0 11.5 28.3 -5.3 -1.2 -4.7 -3.8 0.0 -3.9 -0.0
Leg predicted mass (right) 1.8 9.7 24.2 -4.9 -1.3 -4.0 -3.8 -0.4 -3.3 -0.3
Arm fat mass (left) 2.0 8.0 17.7 -3.8 -2.0 -4.2 -3.1 1.3 -2.9 0.4
Number of self-reported non-cancer illnesses 0.2 0.4 1.3 0.9 0.5 0.0 0.3 0.5 0.2 -1.1
Average weekly champagne plus white wine intake 0.9 1.2 2.5 -1.6 0.5 -1.2 -1.2 0.9 -1.4 0.4
Miserableness 0.6 1.1 1.8 -1.3 -1.3 -1.3 -0.8 -0.3 -1.2 -0.8
Guilty feelings 0.6 0.9 5.2 -0.0 -0.1 0.6 0.5 2.3 0.3 0.4
Wears glasses or contact lenses 3.1 3.6 8.9 -3.0 -0.6 -1.5 -2.8 -0.6 -1.5 -1.8
Ever taken oral contraceptive pill 0.7 0.8 2.6 0.5 -0.8 0.9 0.0 1.1 0.5 1.6
Hearing aid user 0.4 0.4 1.4 -0.0 -1.2 0.1 0.1 -0.4 1.0 0.8
Mother’s age at death 1.2 1.5 4.2 -2.1 -1.2 -1.6 -1.0 0.6 -1.0 0.5
Financial situation satisfaction 0.4 0.5 1.2 -0.1 -0.5 0.0 -1.1 -1.1 0.1 -0.9
Tinnitus: Yes, now most or all of the time 2.8 3.3 9.1 -2.5 -3.0 -1.6 -1.9 0.3 -1.1 0.1
Commuting to job workplace: Public transport 0.5 0.7 1.7 0.0 -1.0 1.3 0.3 0.1 1.3 -0.0
Eye problems/disorders: Glaucoma 1.2 1.4 2.6 -1.6 -1.1 -1.5 -1.2 1.1 -0.5 0.9
Medication: Blood pressure 1.0 2.0 5.0 1.3 1.6 0.4 2.2 -1.6 0.5 -1.2
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.2 0.2 0.8 -1.1 -1.0 -0.6 -0.9 -0.7
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.3 -1.2 1.5 -0.8 -1.0 0.5 -0.4 0.3
High cholesterol (Self-reported) 0.7 1.3 2.9 -0.7 1.7 -1.6 -0.7 -0.3 -0.5 -1.4
Medication: Bendroflumethiazide 0.3 0.5 2.4 -0.7 0.1 -0.2 0.2 -0.3 0.4 -1.6
Medication: Paracetamol 0.1 0.1 0.4 0.0 0.0 0.2 0.2 0.1 0.5 0.7
Medication: Lisinopril 0.6 0.8 3.1 -1.8 0.4 -1.2 -0.7 0.4 -0.1 0.0
Medication: Atorvastatin 2.0 2.5 6.4 -1.8 0.8 -2.5 -1.8 0.2 -1.7 -1.1
Illnesses of father: High blood pressure 1.1 1.4 3.6 -1.5 -0.4 -0.3 -0.9 1.9 -0.0 1.7
Alcohol drinker status: Never 0.5 0.6 2.8 -0.7 1.7 -0.2 -0.8 0.3 0.0 -0.1
Ever smoked 0.8 1.3 6.1 -0.6 -2.5 -1.0 -0.3 -0.5 -1.2 0.0
Basal metabolic rate 2.1 11.5 26.3 -5.1 -1.4 -4.7 -3.9 0.1 -3.9 0.1
Leg fat percentage (left) 1.2 4.3 10.3 -2.2 -1.9 -3.2 -1.9 1.7 -2.0 0.7
Arm fat-free mass (left) 2.5 12.8 27.1 -5.1 -1.1 -5.2 -3.9 -0.1 -4.5 -0.0
Number of operations (self-reported) 0.3 0.4 1.4 0.8 -1.2 0.5 0.4 0.5 -0.1 -0.2
Average weekly beer plus cider intake 0.1 0.2 0.6 0.8 -0.3 -0.5 -0.2 0.4 -0.5 0.2
Irritability 1.2 2.0 4.9 -2.2 -1.4 -0.9 -1.7 1.1 -1.2 -0.7
Risk taking 0.7 1.0 5.4 0.0 -2.3 -0.7 -0.1 -0.2 -1.0 -0.3
Ever had prostate specific antigen (PSA) test 0.6 0.7 3.5 -1.9 -0.7 -0.1 -0.7 -0.3 -0.1 -0.3
Fractured/broken bones in last 5 years 0.5 0.6 1.5 -0.4 -1.0 -0.8 -0.9 0.2 -1.2 -0.3
Age started oral contraceptive pill 0.4 0.5 1.3 -1.1 -0.7 -1.1 0.0 -0.3 -0.5 0.3
Diastolic blood pressure, automated reading 0.9 2.7 6.2 -2.5 -0.6 -1.8 -2.1 -0.8 -1.7 -1.0
Ever depressed for a whole week 0.1 0.1 0.4 -0.6 0.6 -0.5 -0.1 0.0 -0.2 -0.2
Unable to work because of sickness or disability 0.7 0.9 3.8 0.2 -1.4 -0.3 0.5 2.0 0.5 0.4
Commuting to job workplace: Cycle 0.3 0.4 1.2 1.1 0.5 -0.2 -0.1 -0.9 0.2 -0.4
Myopia 0.3 0.5 1.4 0.5 -0.1 0.8 0.6 0.3 1.2 0.7
Vascular/heart problems diagnosed by doctor 1.0 2.7 5.6 1.7 0.1 2.4 1.4 1.2 2.0 1.7
Cholesterol lowering medication 0.5 0.8 3.0 0.3 1.0 0.1 0.3 -0.4 1.0 -1.7
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.2 0.5 -0.1 -0.0 -0.0 0.0 0.1 0.1
Pain experienced in last month 0.4 0.7 1.4 0.0 -1.2 0.9 0.9 0.3 0.9 1.0
Supplements: Calcium 0.5 0.5 2.5 0.0 1.6 0.6 -0.2 0.5 0.7 0.0
Basal cell carcinoma (self-reported) 1.0 1.2 4.0 -1.1 -0.6 -0.2 -2.0 -0.4 -1.0 -1.3
Heart attack/myocardial infarction (self-reported) 2.3 3.0 6.7 -2.2 -0.4 -2.6 -2.0 -0.2 -2.3 -0.1
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 3.2 -1.2 -0.7 0.4 -0.4 1.8 0.8 1.7
Heart disease (siblings) 0.4 0.5 1.2 -0.7 -0.8 -1.1 -0.6 0.4 -0.2 1.0
Alcohol drinker status: Previous 1.1 1.3 3.0 1.7 -1.1 0.8 1.0 0.9 1.2 0.9
Pack years of smoking 0.5 0.7 3.7 0.3 -1.9 -0.6 -0.6 -0.1 -0.1 0.2
Impedance of whole body 0.7 3.3 6.5 2.3 -1.4 2.5 1.3 0.4 1.9 2.0
Leg fat mass (left) 2.0 7.6 17.7 -3.5 -1.8 -4.2 -3.0 1.4 -3.0 0.5
Arm predicted mass (left) 2.0 10.3 22.4 -4.5 -1.1 -4.7 -3.4 -0.2 -4.0 -0.0