TWAS hub - FAM83H

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2970	0.0480	0.0e+00	0.131	0.228	0.282	0.272	0.278	1.2e-15	2.4e-27	1.8e-34	4.3e-33	5.8e-34
2	GTEx	Brain Cerebellar Hemisphere	0.3130	0.1160	6.2e-03	-0.010	NA	0.041	NA	0.061	6.8e-01	NA	3.2e-02	NA	1.1e-02
3	GTEx	Brain Cerebellum	0.2810	0.0850	1.0e-04	0.260	NA	0.155	NA	0.062	2.6e-08	NA	2.4e-05	NA	6.7e-03
4	GTEx	Brain Cortex	0.3000	0.0990	1.9e-03	0.013	NA	0.032	NA	0.021	1.4e-01	NA	4.6e-02	NA	8.6e-02
5	METSIM	Adipose	0.0967	0.0311	8.0e-06	0.012	0.038	0.010	0.036	0.014	5.1e-03	2.0e-06	9.3e-03	3.3e-06	2.7e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.2842	0.0553	2.5e-11	0.109	0.107	0.133	0.130	0.134	6.7e-14	1.2e-13	1.0e-16	2.0e-16	6.6e-17
7	YFS	Blood	0.0314	0.0109	6.0e-05	0.007	0.013	0.010	0.012	0.009	1.4e-03	3.9e-05	3.0e-04	4.0e-05	4.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Prostate Cancer	8.0	11.2	22.6	-4.5	-2.9	-4.8	-3.1	-0.1	-4.1	0.8
Number of live births	6.2	8.8	17.3	4.2	2.3	3.3	3.2	0.8	4.1	0.4
Birth weight	6.0	12.9	20.3	-2.5	-4.5	-4.3	-4.1	-2.0	-4.2	-2.6
Schizophrenia (2014)	5.5	12.1	25.3	4.8	1.4	5.0	4.1	-1.1	3.9	-1.2
Schizophrenia (2018)	5.1	10.6	26.6	5.2	1.3	4.4	3.8	-0.7	3.1	-1.3
Medication: Ventolin 100micrograms inhaler	4.1	5.2	11.1	-2.5	-1.0	-2.8	-3.2	0.3	-3.3	-0.2
Medication: Co-codamol	3.6	4.2	9.4	2.9	0.5	2.4	2.0	1.1	3.1	0.6
Other serious medical condition/disability diagnosed by doctor	3.5	4.5	9.0	3.0	1.1	2.2	2.4	1.3	2.9	1.0
Commuting to job workplace: Walk	3.2	3.4	7.5	2.0	1.3	2.7	2.0	-1.2	2.3	-0.3
Wears glasses or contact lenses	3.1	3.6	8.9	-3.0	-0.6	-1.5	-2.8	-0.6	-1.5	-1.8
Hip circumference	2.9	12.3	30.0	-4.8	-2.0	-5.5	-3.7	0.3	-4.0	-0.0
Asthma (self-reported)	2.9	5.8	13.7	-2.1	-0.8	-3.3	-3.2	0.3	-3.7	-0.7
Alzheimer’s Disease (in father)	2.8	3.0	6.3	0.4	-1.8	-1.4	-1.6	-1.6	-2.1	-2.5
Comparative height size at age 10	2.8	15.5	31.1	-5.6	-3.5	-4.2	-4.9	-0.7	-4.7	1.2
Medication: Aspirin	2.8	3.7	7.4	-2.1	-1.0	-2.7	-2.5	-0.4	-2.5	-0.6
Tinnitus: Yes, now most or all of the time	2.8	3.3	9.1	-2.5	-3.0	-1.6	-1.9	0.3	-1.1	0.1
Trunk fat mass	2.6	11.1	20.1	-4.4	-3.0	-4.5	-4.0	1.4	-3.3	0.9
Weight	2.6	12.8	25.2	-5.0	-2.5	-5.0	-4.1	0.6	-4.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.1	6.5	2.5	1.4	2.5	0.8	-0.5	2.4	-0.5
Arm fat-free mass (left)	2.5	12.8	27.1	-5.1	-1.1	-5.2	-3.9	-0.1	-4.5	-0.0
Hand grip strength (left)	2.4	6.4	12.2	-2.8	-1.9	-2.6	-3.3	-1.2	-3.5	-1.6
Asthma	2.4	4.7	11.1	-1.8	-0.5	-2.9	-3.1	0.0	-3.3	-1.0
Number of full brothers	2.4	3.0	6.3	2.5	-1.5	1.6	2.0	-2.1	1.1	-0.3
Breast cancer (self-reported)	2.4	2.9	9.0	3.0	-0.3	1.8	2.0	-1.4	1.5	-0.1
Medication: Atenolol	2.3	2.9	5.3	-1.1	0.6	-1.6	-1.4	-2.1	-2.2	-2.3
Lung cancer (father)	2.3	2.7	6.3	-1.6	-2.5	-2.1	-1.9	-0.7	-1.2	-0.6
Whole body fat mass	2.3	9.5	18.7	-4.0	-2.6	-4.3	-3.5	1.6	-3.1	0.7
Heart attack/myocardial infarction (self-reported)	2.3	3.0	6.7	-2.2	-0.4	-2.6	-2.0	-0.2	-2.3	-0.1
Respiratory disease	2.2	4.9	9.9	-2.3	-1.3	-2.8	-3.1	0.2	-2.9	-1.3
Hearing difficulty/problems with background noise	2.2	3.6	8.7	-2.5	-0.5	-2.2	-3.0	-0.3	-1.9	-1.1
Trunk predicted mass	2.2	12.3	29.7	-5.5	-1.0	-4.9	-3.8	0.1	-4.2	0.1
Qualifications: O levels/GCSEs or equivalent	2.2	3.6	9.1	3.0	0.7	2.5	2.4	-0.2	1.8	0.1
Arm fat-free mass (right)	2.2	11.5	23.4	-4.8	-1.8	-4.7	-3.8	-0.2	-4.1	-0.3
Arm predicted mass (right)	2.2	11.1	23.6	-4.9	-1.4	-4.8	-3.6	-0.0	-4.1	0.0
Body Mass Index (BMI) (2010)	2.1	2.8	5.7	-2.4	-0.5	-1.7	-2.0	0.2	-2.1	-1.6
Trunk fat-free mass	2.1	12.0	29.1	-5.4	-1.0	-4.8	-3.8	-0.0	-4.2	-0.0
Medication: Cholesterol lowering	2.1	3.2	8.3	-1.9	-0.5	-2.9	-2.2	0.3	-2.3	-0.7
Whole body fat-free mass	2.1	11.9	29.1	-5.4	-1.2	-4.7	-3.9	-0.1	-3.9	-0.1
Basal metabolic rate	2.1	11.5	26.3	-5.1	-1.4	-4.7	-3.9	0.1	-3.9	0.1
Bipolar Disorder or Schizophrenia	2.0	5.0	15.0	0.0	1.1	3.9	2.8	-0.6	2.8	-1.4
Diabetes (father)	2.0	2.4	6.3	2.5	0.5	2.0	1.5	0.7	1.8	0.7
Leg fat-free mass (left)	2.0	10.7	27.1	-5.2	-1.5	-4.4	-4.0	-0.0	-3.2	-0.1
Sitting height	2.0	14.4	39.6	-6.3	-3.1	-3.5	-4.4	-2.1	-3.9	-0.4
Leg predicted mass (left)	2.0	10.8	27.3	-5.2	-1.4	-4.4	-4.0	0.1	-3.2	-0.1
Heart attack	2.0	2.5	5.6	-2.1	-0.4	-2.4	-1.6	-0.3	-2.2	-0.2
Whole body water mass	2.0	11.5	28.3	-5.3	-1.2	-4.7	-3.8	0.0	-3.9	-0.0
Arm fat mass (left)	2.0	8.0	17.7	-3.8	-2.0	-4.2	-3.1	1.3	-2.9	0.4
Medication: Atorvastatin	2.0	2.5	6.4	-1.8	0.8	-2.5	-1.8	0.2	-1.7	-1.1
Leg fat mass (left)	2.0	7.6	17.7	-3.5	-1.8	-4.2	-3.0	1.4	-3.0	0.5
Arm predicted mass (left)	2.0	10.3	22.4	-4.5	-1.1	-4.7	-3.4	-0.2	-4.0	-0.0
Sensitivity / hurt feelings	1.9	3.3	9.4	-3.0	0.3	-0.9	-1.0	3.1	0.5	1.5
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	4.3	-1.5	-0.5	-1.2	-2.1	-0.8	-1.9	-1.4
Stomach or abdominal pain in last month	1.9	2.4	5.5	2.3	0.4	2.3	1.5	-0.5	1.8	-0.2
Loud music exposure frequency	1.9	2.0	4.9	-2.2	-0.8	-1.8	-1.8	0.2	-1.4	-0.1
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	5.7	2.0	1.0	2.4	2.4	-0.0	2.0	1.4
High blood pressure (siblings)	1.9	2.7	5.2	-1.6	-0.7	-2.0	-1.6	-1.0	-2.3	-1.8
Leg fat mass (right)	1.9	7.3	17.3	-3.5	-1.8	-4.2	-2.8	1.5	-2.8	0.6
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	11.5	0.0	0.8	1.6	0.2	-3.4	1.5	-2.0
Relative age of first facial hair	1.8	3.7	9.8	2.2	0.1	3.1	2.4	-0.1	2.2	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.0	8.3	1.3	2.4	2.6	2.4	-0.1	2.9	0.4
Depression (self-reported)	1.8	2.2	4.9	2.0	0.6	2.2	0.9	0.1	2.0	-0.8
Leg fat-free mass (right)	1.8	9.8	24.4	-4.9	-1.3	-4.1	-3.9	-0.4	-3.3	-0.3
Eye problems/disorders: Cataract	1.8	2.0	3.0	1.7	1.0	1.1	1.5	1.0	1.7	1.7
Leg predicted mass (right)	1.8	9.7	24.2	-4.9	-1.3	-4.0	-3.8	-0.4	-3.3	-0.3
Neuroticism (2016)	1.7	2.4	6.2	-1.9	-0.1	-1.5	-2.5	1.0	-1.6	-1.0
Height	1.7	32.7	77.4	-8.8	-3.5	-6.7	-7.2	0.8	-6.1	2.1
Trunk fat percentage	1.7	6.8	11.7	-3.1	-2.9	-3.4	-3.2	1.2	-2.3	0.7
Arm fat mass (right)	1.7	7.1	16.6	-3.5	-1.8	-4.1	-2.8	1.4	-2.8	0.5
Wheeze or whistling in the chest in last year	1.7	3.1	6.5	-1.3	-1.9	-2.4	-1.8	-0.6	-2.6	-0.1
Medication: Blood pressure	1.7	3.0	6.7	-2.2	-0.4	-1.4	-2.6	-0.6	-1.4	-2.1
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.6	-1.7	-1.3	-1.7	-1.9	-0.1	-1.4	-0.3
Emphysema/chronic bronchitis	1.6	1.8	5.0	-0.6	2.2	-1.6	-1.4	-0.2	-1.6	-0.6
Breast Cancer	1.5	3.5	8.2	-2.9	-0.1	-2.2	-2.5	1.1	-2.0	-0.1
Mean Putamen Volume	1.5	1.7	3.3	1.1	1.8	1.8	1.4	-0.1	1.4	0.1
Waist circumference	1.5	5.6	13.8	-2.7	-1.7	-3.7	-2.6	0.2	-2.9	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	6.4	1.1	2.1	2.5	2.4	-0.8	2.4	-0.6
Illnesses of siblings	1.5	2.1	4.8	1.4	0.7	2.2	1.8	0.3	1.8	0.9
Standing height	1.5	15.2	38.3	-6.2	-3.5	-3.9	-4.8	-0.7	-3.9	1.6
Birth weight of first child	1.5	2.8	6.0	-2.3	0.3	-1.8	-2.2	-0.2	-2.5	-0.3
Body fat percentage	1.5	5.8	11.2	-2.7	-2.7	-3.3	-2.7	1.6	-2.1	0.8
Angina	1.4	1.8	6.1	-0.8	-0.4	-2.5	-1.7	0.0	-1.6	0.1
Hand grip strength (right)	1.4	3.9	9.5	-1.7	-1.2	-2.7	-1.8	-1.2	-3.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	4.2	2.0	1.6	1.5	1.0	-0.5	1.1	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.2	1.7	-0.2	1.1	1.8	1.5	1.3	0.9
Number of children fathered	1.4	1.6	4.1	-1.4	-0.3	-2.0	-1.5	0.2	-1.2	-1.0
Angina (self-reported)	1.4	1.9	6.1	-0.9	-0.6	-2.5	-1.8	0.0	-1.7	0.1
Medication: Aspirin	1.4	1.9	3.9	-1.2	0.0	-2.0	-1.9	-0.7	-1.8	-0.7
BMI	1.3	7.6	16.5	-3.6	-2.1	-4.1	-2.8	1.8	-2.9	-0.2
Breastfed as a baby	1.3	1.7	3.0	-1.6	-1.7	-1.5	-1.2	0.5	-1.1	-0.8
Medication: Amlodipine	1.3	1.8	3.9	-1.7	-0.4	-1.3	-2.0	-0.5	-1.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	6.1	-2.4	-2.5	-1.2	-1.9	-0.6	-0.7	1.1
Primary Biliary Cirrhosis	1.2	1.7	5.4	0.8	-0.7	1.2	2.3	0.4	1.1	1.6
Hearing difficulty/problems: Yes	1.2	1.8	4.7	-1.8	-0.4	-1.1	-2.2	1.6	-0.3	0.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.8	0.7	-0.5	0.8	0.9	1.4	1.6	1.7
Chronic bronchitis/emphysema (father)	1.2	1.4	2.8	1.4	1.7	0.7	1.3	1.6	0.7	0.4
Medication: Lansoprazole	1.2	1.4	3.0	-1.5	-1.4	-1.3	-0.5	1.7	0.1	0.8
Pulse wave reflection index	1.2	1.5	4.1	-0.1	-1.6	-0.6	-0.1	-2.0	-0.7	-1.8
Overall health rating	1.2	2.6	5.3	2.3	1.5	1.7	1.7	0.5	2.2	-0.1
Illnesses of father: None of the above (group 1)	1.2	1.4	3.1	1.2	-0.2	1.5	1.7	-0.1	1.5	1.0
Mother’s age at death	1.2	1.5	4.2	-2.1	-1.2	-1.6	-1.0	0.6	-1.0	0.5
Eye problems/disorders: Glaucoma	1.2	1.4	2.6	-1.6	-1.1	-1.5	-1.2	1.1	-0.5	0.9
Leg fat percentage (left)	1.2	4.3	10.3	-2.2	-1.9	-3.2	-1.9	1.7	-2.0	0.7
Irritability	1.2	2.0	4.9	-2.2	-1.4	-0.9	-1.7	1.1	-1.2	-0.7
Crohns Disease (2012)	1.1	1.8	5.4	-1.2	-1.1	-1.7	-0.2	1.2	-0.6	2.3
LDL Cholesterol	1.1	1.8	4.5	0.3	0.1	1.5	0.4	-1.8	1.6	-2.1
Townsend deprivation index at recruitment	1.1	1.6	3.2	1.2	-0.7	0.9	1.7	-0.5	1.8	1.4
Past tobacco smoking	1.1	2.0	9.1	0.9	3.0	1.3	0.1	-0.1	1.4	-0.5
Hair/balding pattern: Pattern 2	1.1	1.4	3.9	-0.2	-0.5	-1.2	-1.1	2.0	-1.0	1.4
Arm fat percentage (right)	1.1	4.3	10.4	-2.6	-1.5	-3.2	-2.3	1.5	-1.8	0.4
Length of working week for main job	1.1	1.2	2.6	1.6	-0.6	1.1	1.2	1.4	0.9	0.5
Glaucoma (self-reported)	1.1	1.3	4.6	-0.8	-0.9	-0.4	-0.3	1.4	0.8	2.2
Gout (self-reported)	1.1	1.5	4.2	-1.2	-0.7	-2.0	-0.9	1.3	-1.4	0.4
Leg fat percentage (right)	1.1	4.2	10.4	-2.2	-1.8	-3.2	-1.9	1.9	-1.7	0.8
Supplements: Vitamin C	1.1	1.3	2.8	0.3	-1.1	-1.3	-1.1	-0.4	-1.4	-1.7
Smoking status: Previous	1.1	1.7	5.6	-0.9	-2.4	-1.5	-0.5	0.3	-1.5	0.7
Arm fat percentage (left)	1.1	4.5	9.4	-2.6	-2.1	-3.1	-2.4	1.3	-1.8	0.1
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.8	-1.5	-1.3	-0.7	-1.7	-0.4	-1.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.6	1.5	1.2	1.6	0.3	-0.5	0.5	-1.3
Illnesses of father: High blood pressure	1.1	1.4	3.6	-1.5	-0.4	-0.3	-0.9	1.9	-0.0	1.7
Alcohol drinker status: Previous	1.1	1.3	3.0	1.7	-1.1	0.8	1.0	0.9	1.2	0.9
Lupus	1.0	1.5	3.5	-1.4	-1.9	-1.2	-1.4	-1.0	-0.9	-0.1
Serious illness, injury or assault to yourself	1.0	1.2	4.0	-1.2	-1.1	-2.0	-1.0	0.3	-1.0	0.1
Medication: Levothyroxine sodium	1.0	1.7	4.2	-0.6	-1.5	-1.4	-0.1	2.0	-0.8	1.7
Body mass index (BMI)	1.0	4.3	12.2	-2.4	-0.9	-3.5	-2.0	0.9	-2.4	-0.5
Alcohol intake versus 10 years previously	1.0	1.5	3.2	1.5	-1.5	0.6	1.1	1.8	0.7	1.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.1	1.0	1.5	1.1	1.4	-0.1	0.4	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.7	1.2	0.6	1.2	-0.1	-1.6	0.5	-1.5
Medication: Blood pressure	1.0	2.0	5.0	1.3	1.6	0.4	2.2	-1.6	0.5	-1.2
Vascular/heart problems diagnosed by doctor	1.0	2.7	5.6	1.7	0.1	2.4	1.4	1.2	2.0	1.7
Basal cell carcinoma (self-reported)	1.0	1.2	4.0	-1.1	-0.6	-0.2	-2.0	-0.4	-1.0	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.2	-1.2	-0.7	0.4	-0.4	1.8	0.8	1.7
Ovarian Cancer	0.9	1.1	2.8	-1.1	-1.7	-0.4	-0.4	-0.8	-1.1	-1.4
Blood clot in the leg (DVT)	0.9	1.2	3.1	-1.0	-0.4	0.6	-0.3	1.7	0.9	1.8
Exposure to tobacco smoke outside home	0.9	1.2	3.9	2.0	-0.7	1.3	-0.0	-0.8	-0.2	-1.3
Heart disease (mother)	0.9	1.0	1.7	-0.2	-1.2	-0.8	-1.3	-1.1	-0.9	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.9	-1.2	1.7	-0.3	-0.6	1.6	-0.2	0.3
Average weekly champagne plus white wine intake	0.9	1.2	2.5	-1.6	0.5	-1.2	-1.2	0.9	-1.4	0.4
Diastolic blood pressure, automated reading	0.9	2.7	6.2	-2.5	-0.6	-1.8	-2.1	-0.8	-1.7	-1.0
Alzheimer’s Disease (including proxy)	0.8	1.1	3.3	-0.2	0.1	-1.4	-0.8	-0.7	-1.8	-1.2
Crohns Disease (2017)	0.8	1.7	5.9	0.6	0.4	0.3	1.6	1.5	0.6	2.4
Diabetes (mother)	0.8	1.0	2.5	1.4	-0.3	1.0	1.1	-0.5	1.6	0.4
Supplements: Glucosamine	0.8	1.0	2.6	-1.6	-1.6	-1.0	-0.8	0.1	-0.6	-0.2
High blood pressure (mother)	0.8	1.1	3.8	-1.2	-2.0	-1.2	-0.8	-0.2	-0.8	-0.0
Nervous feelings	0.8	1.4	2.3	0.9	0.9	1.5	0.7	-1.1	1.5	-1.4
Had other major operations	0.8	1.0	5.1	0.3	-2.2	-0.0	-0.2	-0.7	-0.9	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.7	-1.2	-0.5	-1.3	-1.2	1.0	-0.8	0.3
Age at first live birth	0.8	1.4	4.0	-2.0	-0.8	-1.3	-0.9	-0.3	-1.4	-1.0
Medication: Allopurinol	0.8	1.1	2.5	-1.6	-1.0	-1.2	-1.0	1.2	-0.6	0.4
Knee pain experienced in last month	0.8	1.3	3.9	-0.3	0.8	-0.7	-1.1	-0.7	-1.5	-2.0
Illnesses of father: Heart disease	0.8	1.0	4.4	0.2	-0.5	-0.6	-0.7	-1.2	-0.5	-2.1
Ever smoked	0.8	1.3	6.1	-0.6	-2.5	-1.0	-0.3	-0.5	-1.2	0.0
Worry (Nagel 2018)	0.7	1.6	4.3	1.3	0.3	2.1	1.0	-0.0	1.5	-1.3
Cardiovascular Disease	0.7	2.2	3.1	-1.5	1.2	-1.7	-0.9	-1.6	-1.6	-1.8
Ever had hysterectomy (womb removed)	0.7	0.8	2.8	1.7	0.4	1.2	0.9	-0.4	0.6	-0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.4	-1.1	-0.3	-1.5	-0.7	-0.2	-0.9	-0.2
Medication for hormone replacement therapy	0.7	0.8	2.2	-0.4	0.7	-1.0	-0.5	1.0	-1.5	0.5
Impedance of leg (right)	0.7	3.4	6.7	2.6	-0.3	2.0	1.9	1.1	1.6	2.3
High blood pressure	0.7	1.9	3.7	-1.4	-0.1	-1.9	-1.0	-1.0	-1.7	-1.8
Impedance of leg (left)	0.7	3.3	7.8	2.8	-0.5	2.1	2.0	0.8	1.1	2.1
Pain all over the body in last month	0.7	0.8	2.8	0.5	-1.2	-0.4	-0.1	1.7	0.3	0.9
Fluid intelligence score	0.7	1.4	3.9	-0.0	-1.3	-0.8	-0.9	-1.4	-0.6	-2.0
Worrier / anxious feelings	0.7	1.4	5.2	0.5	0.1	1.7	0.5	-0.7	0.6	-2.3
Pulse wave Arterial Stiffness index	0.7	0.8	1.3	-1.0	-0.5	-1.0	-0.4	-0.9	-1.1	-1.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.5	-0.6	-0.1	-0.9	-0.0	1.0	-0.9	1.6
Worry too long after embarrassment	0.7	1.2	3.0	-0.8	-1.6	-0.4	-1.7	1.5	-0.1	0.0
Health satisfaction	0.7	0.9	4.8	0.8	2.2	-0.0	0.0	-0.5	-0.3	-0.9
Number of full sisters	0.7	0.9	2.8	-0.9	-0.0	-1.0	0.5	0.9	-0.6	1.7
Hypertension (Self-reported)	0.7	2.0	5.3	-1.3	0.6	-1.4	-0.9	-1.3	-1.3	-2.3
Medication for cholesterol	0.7	1.0	3.7	-0.1	-1.9	0.4	-0.6	0.6	-0.0	1.6
Medication: Gliclazide	0.7	0.8	1.8	-1.0	-1.2	-0.8	-1.3	0.3	-0.4	0.6
Ever taken oral contraceptive pill	0.7	0.8	2.6	0.5	-0.8	0.9	0.0	1.1	0.5	1.6
High cholesterol (Self-reported)	0.7	1.3	2.9	-0.7	1.7	-1.6	-0.7	-0.3	-0.5	-1.4
Risk taking	0.7	1.0	5.4	0.0	-2.3	-0.7	-0.1	-0.2	-1.0	-0.3
Unable to work because of sickness or disability	0.7	0.9	3.8	0.2	-1.4	-0.3	0.5	2.0	0.5	0.4
Impedance of whole body	0.7	3.3	6.5	2.3	-1.4	2.5	1.3	0.4	1.9	2.0
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.9	-1.3	-0.9	-2.0	-1.2	-1.4	-1.5	-0.7
Fasting Glucose	0.6	0.8	2.0	-0.2	-0.7	1.2	0.1	-1.1	1.4	-0.5
HDL Cholesterol	0.6	1.0	1.8	1.1	1.3	1.3	0.7	-0.9	0.9	-0.2
Waist Hip Ratio (WHR)	0.6	2.7	7.3	2.7	-0.3	2.4	1.2	-1.3	1.5	-0.6
Severe depression (siblings)	0.6	0.7	1.7	-0.2	-0.9	-0.2	1.0	0.5	0.8	1.3
Taking other prescription medications	0.6	1.0	2.9	-0.8	0.1	-1.2	-1.2	1.7	-0.5	-0.6
Qualifications: CSEs or equivalent	0.6	0.8	1.7	0.9	1.0	0.3	1.3	0.7	1.1	0.7
Had menopause	0.6	0.7	2.8	-0.8	-1.7	-0.9	-0.2	-0.3	-0.8	0.3
Impedance of arm (left)	0.6	2.7	6.8	1.5	-1.5	2.6	0.7	-0.1	2.2	1.5
Hair/balding pattern: Pattern 4	0.6	1.5	4.1	-0.5	-0.5	-2.0	-1.6	0.3	-1.9	-0.2
Medication: Ibuprofen	0.6	0.7	1.7	1.2	1.3	0.9	0.3	0.0	0.7	-0.4
Medication: Seretide 50 evohaler	0.6	0.7	2.0	-0.1	0.0	-0.9	-1.4	-0.6	-1.0	-0.7
Mean time to correctly identify matches	0.6	1.1	3.1	-1.7	-1.8	-0.8	-0.5	-0.4	-0.6	-0.8
Family relationship satisfaction	0.6	0.7	2.2	0.3	-0.1	-0.0	-0.2	1.5	1.0	1.3
Illnesses of siblings: Diabetes	0.6	0.7	1.4	-1.1	-1.2	-0.4	-1.1	0.6	-0.6	0.1
Loneliness, isolation	0.6	0.9	2.3	-1.5	0.3	-0.1	-1.2	0.4	-0.0	-1.5
Long-standing illness, disability or infirmity	0.6	0.9	2.1	1.2	1.4	0.4	0.6	0.9	1.1	0.4
Back pain experienced in last month	0.6	0.9	3.0	0.8	1.7	-0.3	-0.2	1.1	-0.4	-0.9
Osteoarthritis (self-reported)	0.6	0.8	1.9	0.4	-0.8	-1.4	-0.5	0.8	-0.6	-1.4
Miserableness	0.6	1.1	1.8	-1.3	-1.3	-1.3	-0.8	-0.3	-1.2	-0.8
Guilty feelings	0.6	0.9	5.2	-0.0	-0.1	0.6	0.5	2.3	0.3	0.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.3	-1.2	1.5	-0.8	-1.0	0.5	-0.4	0.3
Medication: Lisinopril	0.6	0.8	3.1	-1.8	0.4	-1.2	-0.7	0.4	-0.1	0.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	3.5	-1.9	-0.7	-0.1	-0.7	-0.3	-0.1	-0.3
Depressed Affect (Nagel 2018)	0.5	1.0	2.1	-1.1	-1.4	-0.5	-0.5	0.8	-0.5	-1.4
Irritable Bowel Disease (IBD)	0.5	1.1	3.7	1.0	-0.1	-0.1	1.4	1.2	0.3	1.9
Heel T-Score	0.5	3.9	11.3	1.1	3.4	2.2	2.2	-0.0	2.2	-0.2
Number of treatments/medications taken	0.5	0.9	2.1	-0.8	0.4	-1.5	-1.2	0.4	-1.4	-0.6
Pack years adult smoking proportion	0.5	0.7	4.0	0.5	-2.0	-0.4	-0.4	0.0	0.2	0.4
Alcohol usually taken with meals	0.5	0.8	2.2	-1.0	0.0	-1.5	-0.5	0.3	-1.4	0.2
Medication: Simvastatin	0.5	0.7	3.4	0.4	-0.3	-0.4	-0.4	-0.8	-0.3	-1.8
Impedance of arm (right)	0.5	2.2	4.8	1.4	-0.5	2.2	0.7	0.3	2.0	2.0
Hair/balding pattern: Pattern 3	0.5	0.7	3.2	-0.8	0.3	0.1	-0.6	-0.8	-0.0	-1.8
Mouth/teeth dental problems: Dentures	0.5	0.8	2.0	-1.1	0.6	-1.4	-0.9	1.0	-0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.8	-0.3	-0.9	-1.3	-0.5	1.1	-1.3	0.8
Comparative body size at age 10	0.5	1.4	4.3	-1.0	0.5	-2.1	-0.6	0.1	-2.0	-0.1
Pulse wave peak to peak time	0.5	0.6	1.6	0.7	0.1	0.8	0.1	0.8	1.0	1.3
Neck or shoulder pain in last month	0.5	0.7	1.6	-0.1	1.2	-0.5	-0.4	0.1	-1.0	-1.3
Migraine (self-reported)	0.5	0.6	1.2	1.1	1.0	-0.4	-1.0	0.9	-0.1	-0.1
Suffer from ‘nerves’	0.5	0.8	1.6	-1.3	-0.6	-1.0	-1.0	0.4	-0.8	-1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	2.7	-0.4	0.4	-1.6	-0.5	0.2	-0.7	0.0
Osteoporosis (self-reported)	0.5	0.6	1.3	0.7	1.1	0.2	0.8	0.8	0.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.6	1.2	1.6	1.3	0.5	-0.8	0.4	-0.6
Commuting to job workplace: Public transport	0.5	0.7	1.7	0.0	-1.0	1.3	0.3	0.1	1.3	-0.0
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.2	0.2	0.8	-1.1	-1.0	-0.6	-0.9	-0.7
Alcohol drinker status: Never	0.5	0.6	2.8	-0.7	1.7	-0.2	-0.8	0.3	0.0	-0.1
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-0.4	-1.0	-0.8	-0.9	0.2	-1.2	-0.3
Cholesterol lowering medication	0.5	0.8	3.0	0.3	1.0	0.1	0.3	-0.4	1.0	-1.7
Supplements: Calcium	0.5	0.5	2.5	0.0	1.6	0.6	-0.2	0.5	0.7	0.0
Pack years of smoking	0.5	0.7	3.7	0.3	-1.9	-0.6	-0.6	-0.1	-0.1	0.2
Depression (Nagel 2018)	0.4	0.7	3.5	-0.7	-0.6	0.3	0.0	1.9	0.2	0.2
Neuroticism (Nagel 2018)	0.4	0.9	2.2	-1.0	-1.3	0.2	-0.5	1.5	-0.0	-0.9
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.0	-0.6	-0.0	-1.4	-0.9	-0.9	-1.3	-1.1
Rheumatoid Arthritis	0.4	0.5	1.2	0.8	-0.1	1.1	0.8	0.4	1.1	0.4
Blood Eosinophil Count	0.4	3.4	5.9	-2.1	-2.0	-2.4	-1.7	0.4	-2.3	0.7
Smoking Status	0.4	1.0	4.1	-0.5	-2.0	-0.2	0.8	-0.8	-0.9	-0.3
Hypothyroidism (self reported)	0.4	1.0	3.0	-0.2	-0.3	-1.1	0.1	1.7	-1.0	1.4
Systolic blood pressure, automated reading	0.4	1.1	3.9	-2.0	1.0	-0.6	-1.2	-0.8	-0.5	-0.4
Average weekly fortified wine intake	0.4	0.5	1.3	-0.8	0.1	-1.1	-0.0	-1.1	-0.6	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	-0.7	-0.5	-0.6	-0.4	1.1	-0.9	0.5
Relative age voice broke	0.4	0.6	2.1	1.5	-0.5	1.0	0.5	-0.5	0.4	-0.0
Multivitamins +/- minerals	0.4	0.5	1.1	-0.8	-0.3	-0.9	-1.0	-0.3	-1.0	0.4
Qualifications: None of the above	0.4	0.9	3.0	-0.4	-1.7	-1.3	-0.1	-1.1	-0.9	-0.1
Allergy	0.4	0.9	1.8	0.7	-0.4	1.3	1.3	-0.6	1.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.8	0.7	0.6	0.6	0.5	0.7	0.4	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	-1.2	-0.3	-0.8	-1.0	0.5	-0.0	-0.8
Illnesses of mother	0.4	0.5	1.2	1.0	1.1	0.9	0.3	0.2	0.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.9	0.4	-1.4	0.7	-0.0	0.5	0.9	-1.1
Peak expiratory flow (PEF)	0.4	1.0	3.0	0.1	1.2	1.1	-0.0	-1.7	0.7	-1.0
Pulse rate, automated reading	0.4	1.2	3.2	1.1	0.8	1.4	-0.0	1.1	1.8	-0.2
Average weekly red wine intake	0.4	0.5	1.2	-0.1	-0.4	-0.9	0.4	-0.6	-1.1	-0.9
Ever had bowel cancer screening	0.4	0.4	1.5	-1.2	0.7	0.3	-0.4	0.2	-0.0	-0.9
Smoking status: Current	0.4	0.7	1.7	-0.1	-0.9	0.4	1.1	-1.3	-0.1	-0.9
Hearing aid user	0.4	0.4	1.4	-0.0	-1.2	0.1	0.1	-0.4	1.0	0.8
Financial situation satisfaction	0.4	0.5	1.2	-0.1	-0.5	0.0	-1.1	-1.1	0.1	-0.9
Age started oral contraceptive pill	0.4	0.5	1.3	-1.1	-0.7	-1.1	0.0	-0.3	-0.5	0.3
Pain experienced in last month	0.4	0.7	1.4	0.0	-1.2	0.9	0.9	0.3	0.9	1.0
Heart disease (siblings)	0.4	0.5	1.2	-0.7	-0.8	-1.1	-0.6	0.4	-0.2	1.0
Schizophrenia vs Biploar Disorder	0.3	0.4	1.6	0.0	-1.3	-0.2	0.0	-0.7	-0.3	0.6
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	-0.4	0.8	-0.6	-0.3	0.7	-0.5	-0.1
Reaction Time	0.3	0.5	1.4	-0.3	-1.2	0.3	0.4	-0.7	0.7	-0.8
Ulcerative Colitis	0.3	0.4	2.0	0.6	-1.4	-0.3	-0.3	0.6	-0.2	0.2
Systolic Blood Pressure	0.3	1.7	6.8	-1.1	2.6	0.1	-1.2	-0.9	-0.2	-1.2
Lung FEV1/FVC ratio	0.3	1.5	4.0	0.8	0.4	1.3	-0.5	-2.0	-0.2	-2.0
Neuroticism	0.3	0.8	1.6	-1.3	-0.7	0.8	0.1	1.1	1.1	-0.4
Chronotype (morning person)	0.3	0.7	2.8	-0.9	-0.3	-0.9	0.1	-1.7	-0.2	0.3
Tanning	0.3	4.2	9.6	-2.3	-1.0	-2.6	-2.4	0.8	-3.1	-0.6
Average weekly spirits intake	0.3	0.4	0.8	-0.8	0.4	-0.3	-0.9	0.7	0.2	0.6
Supplements: Zinc	0.3	0.3	1.0	-1.0	-0.1	-0.3	-0.4	0.8	-0.5	0.4
Current tobacco smoking	0.3	0.6	1.9	-0.1	-0.5	0.6	1.4	-1.0	0.5	-0.4
Fed-up feelings	0.3	0.5	2.5	-0.7	-1.6	0.1	0.2	0.3	-0.3	-0.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	0.7	1.0	0.7	0.8	0.6	0.7	0.8
Mouth/teeth dental problems	0.3	0.5	2.4	-0.2	-1.6	-0.2	-0.3	0.1	-0.3	0.9
Medication: Ramipril	0.3	0.3	0.9	1.0	-0.5	-0.6	0.4	-0.6	-0.3	0.1
Neuroticism score	0.3	0.6	1.6	-1.3	-0.5	0.4	-0.6	0.9	0.5	-0.9
Happiness	0.3	0.4	1.0	-0.3	-0.5	-0.3	-0.7	1.0	0.3	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.4	-1.2	-0.5	-0.4	-0.2	-0.1	-0.3	-0.3
Prospective memory result	0.3	0.3	1.3	-0.3	-0.6	-0.0	0.2	0.5	-0.5	1.2
Tense / ‘highly strung’	0.3	0.6	2.2	-1.2	0.2	0.2	-0.4	-0.3	-0.3	-1.5
Qualifications: College or University degree	0.3	1.0	4.1	2.0	0.4	1.4	0.8	-0.1	0.6	0.3
Chest pain or discomfort	0.3	0.5	1.2	1.1	-0.7	-0.3	0.1	-0.6	-0.5	-0.9
Leg pain on walking	0.3	0.4	1.5	-0.3	-0.6	-0.7	-0.7	1.2	-0.0	0.3
Mood swings	0.3	0.6	1.3	-0.4	-0.4	-0.7	-0.6	0.7	-1.1	-1.0
Friendships satisfaction	0.3	0.4	1.4	-0.5	-0.4	-0.2	-1.2	-0.5	-0.3	-0.6
Mineral and other dietary supplements	0.3	0.5	1.9	1.4	0.1	0.7	0.8	0.0	0.5	-0.1
Medication: Bendroflumethiazide	0.3	0.5	2.4	-0.7	0.1	-0.2	0.2	-0.3	0.4	-1.6
Number of operations (self-reported)	0.3	0.4	1.4	0.8	-1.2	0.5	0.4	0.5	-0.1	-0.2
Commuting to job workplace: Cycle	0.3	0.4	1.2	1.1	0.5	-0.2	-0.1	-0.9	0.2	-0.4
Myopia	0.3	0.5	1.4	0.5	-0.1	0.8	0.6	0.3	1.2	0.7
Ulcerative Colitis (UC)	0.2	0.4	0.9	0.9	-0.3	-0.7	0.6	0.6	-0.0	1.0
Triglycerides	0.2	0.3	1.0	-0.3	-1.0	0.5	0.0	0.8	0.6	0.1
Blood Red Count	0.2	1.6	4.9	-0.4	-0.5	0.7	-0.6	-2.2	-0.2	-2.2
Blood White Count	0.2	1.3	4.9	0.3	-1.4	-0.5	-1.2	2.2	-0.4	-0.2
Lung FVC	0.2	1.1	2.6	1.6	0.8	1.0	1.2	0.0	0.2	-1.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	-0.4	-0.4	-0.5	-0.2	1.1	-0.6	0.4
Vitamin and mineral supplements	0.2	0.2	0.6	-0.2	-0.0	0.7	0.5	-0.5	0.6	-0.1
Medication: Metformin	0.2	0.2	0.6	-0.2	0.3	0.2	-0.7	-0.8	0.1	-0.6
Age when periods started (menarche)	0.2	0.5	1.9	0.8	-0.0	0.7	0.2	-0.2	0.4	1.4
Number of incorrect matches in round	0.2	0.3	1.1	-0.5	-1.0	-0.3	0.4	0.7	-0.5	0.4
Forced vital capacity (FVC)	0.2	0.6	1.6	-1.1	-0.3	-0.6	-0.7	-0.6	-1.3	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.0	0.0	0.3	-0.1	-0.8	0.0	-0.8
Financial difficulties in last 2 years	0.2	0.3	0.9	-0.5	-0.7	-0.4	-0.6	0.9	-0.3	-0.1
Time employed in main current job	0.2	0.3	0.6	-0.5	0.8	0.3	-0.3	0.5	0.1	0.8
Father’s age at death	0.2	0.2	1.0	-0.1	-1.0	0.1	-0.0	0.4	0.0	0.5
Falls in the last year	0.2	0.3	0.9	-0.1	0.6	0.1	0.9	0.0	1.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.3	-0.5	0.6	-0.1	-0.8	-1.1	-1.1	-0.9
Pulse rate	0.2	0.4	1.0	1.0	0.7	0.0	0.5	0.6	0.8	0.4
Noisy workplace	0.2	0.3	1.0	-1.0	0.0	-0.6	0.1	-0.7	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.6	0.3	1.2	0.7	-0.3	-0.8	-0.4	-0.9
Eye problems/disorders: None of the above	0.2	0.2	0.8	0.4	-0.3	-0.1	0.0	-0.5	-0.9	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	-0.9	-0.3	-0.3	-0.1	0.8	-0.7	0.2
Medication: Omeprazole	0.2	0.3	1.2	1.1	0.5	0.2	-0.1	-0.5	-0.1	-0.4
Alcohol intake frequency.	0.2	0.5	1.2	0.9	-0.1	0.2	0.9	0.1	1.1	0.8
Had major operations	0.2	0.2	0.4	-0.5	-0.1	-0.5	-0.5	0.4	-0.5	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.5	-0.2	0.4	-0.6	-0.2	-0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.2	-0.2	0.1	-0.2	1.1	0.6	-0.1	0.6
Number of self-reported non-cancer illnesses	0.2	0.4	1.3	0.9	0.5	0.0	0.3	0.5	0.2	-1.1
Bipolar Disorder (2018)	0.1	0.2	0.5	0.7	0.2	0.5	0.0	0.1	0.7	-0.3
Age at First Birth	0.1	0.2	0.4	0.2	0.4	-0.2	-0.3	0.5	-0.7	-0.2
HbA1C	0.1	0.1	0.2	-0.3	0.2	-0.4	0.3	0.3	0.2	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.0	0.1	-0.3	-0.7	-0.2	-0.4	-0.4
Blood Platelet Count	0.1	1.6	6.1	1.6	0.2	-1.3	-0.6	-0.6	-0.4	-2.5
Allergy or Eczema	0.1	0.4	0.7	0.8	0.3	0.5	0.7	-0.4	0.8	0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.1	-0.3	0.3	-0.4	-0.7	0.4	-0.2
Hair Pigment	0.1	3.8	7.7	-1.2	-2.8	-2.7	-1.3	-1.6	-2.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.7	0.8	-0.1	-0.1	-0.1	-0.1	-0.1	-0.5
Maternal smoking around birth	0.1	0.2	0.5	0.5	-0.7	0.2	-0.3	-0.4	0.0	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.6	0.8	-0.1	0.4	0.3	0.3	0.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	0.6	-0.7	0.2	0.1	0.3	0.0	-0.2
Diabetes (self-reported)	0.1	0.1	0.4	0.2	-0.2	0.2	0.4	0.1	0.7	0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	0.2	-0.7	-0.3	-0.1	-0.6	-0.6	-0.9
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.3	-0.1	-0.4	0.2	0.4	-0.2	-0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.2	0.0	0.0	0.6	0.3	-0.1	0.4
Headache pain in last month	0.1	0.2	0.5	0.7	0.4	0.3	0.5	-0.5	0.5	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.4	1.2	-0.7	0.5	-0.5	-0.6	-0.5	-1.1	-0.4
Shortness of breath walking on level ground	0.1	0.1	0.5	-0.5	0.3	-0.7	-0.1	0.4	-0.2	0.1
Age at last live birth	0.1	0.1	0.7	-0.4	-0.8	0.1	0.3	0.0	0.2	0.2
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.2	0.0	0.5	0.2	0.1	0.7	0.7
Medication: Paracetamol	0.1	0.1	0.4	0.0	0.0	0.2	0.2	0.1	0.5	0.7
Average weekly beer plus cider intake	0.1	0.2	0.6	0.8	-0.3	-0.5	-0.2	0.4	-0.5	0.2
Ever depressed for a whole week	0.1	0.1	0.4	-0.6	0.6	-0.5	-0.1	0.0	-0.2	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.2	0.0	0.3	0.0	0.4	-0.2	0.0	0.1
Medication: Paracetamol	0.0	0.1	0.2	-0.3	0.2	0.0	0.4	-0.2	0.4	0.0
Qualifications: nursing, teaching	0.0	0.1	0.2	0.4	0.3	0.2	0.1	-0.4	0.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.2	0.5	-0.1	-0.0	-0.0	0.0	0.1	0.1

Hub : Genes

FAM83H

Models

Trait associations