Hub : Genes

FAM83H

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2970	0.0480	0.0e+00	0.131	0.228	0.282	0.272	0.278	1.2e-15	2.4e-27	1.8e-34	4.3e-33	5.8e-34
2	GTEx	Brain Cerebellar Hemisphere	0.3130	0.1160	6.2e-03	-0.010	NA	0.041	NA	0.061	6.8e-01	NA	3.2e-02	NA	1.1e-02
3	GTEx	Brain Cerebellum	0.2810	0.0850	1.0e-04	0.260	NA	0.155	NA	0.062	2.6e-08	NA	2.4e-05	NA	6.7e-03
4	GTEx	Brain Cortex	0.3000	0.0990	1.9e-03	0.013	NA	0.032	NA	0.021	1.4e-01	NA	4.6e-02	NA	8.6e-02
5	METSIM	Adipose	0.0967	0.0311	8.0e-06	0.012	0.038	0.010	0.036	0.014	5.1e-03	2.0e-06	9.3e-03	3.3e-06	2.7e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.2842	0.0553	2.5e-11	0.109	0.107	0.133	0.130	0.134	6.7e-14	1.2e-13	1.0e-16	2.0e-16	6.6e-17
7	YFS	Blood	0.0314	0.0109	6.0e-05	0.007	0.013	0.010	0.012	0.009	1.4e-03	3.9e-05	3.0e-04	4.0e-05	4.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.2	0.5	0.7	0.2	0.5	0.0	0.1	0.7	-0.3
Bipolar Disorder or Schizophrenia	2.0	5.0	15.0	0.0	1.1	3.9	2.8	-0.6	2.8	-1.4
Depressed Affect (Nagel 2018)	0.5	1.0	2.1	-1.1	-1.4	-0.5	-0.5	0.8	-0.5	-1.4
Depression (Nagel 2018)	0.4	0.7	3.5	-0.7	-0.6	0.3	0.0	1.9	0.2	0.2
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.9	-1.3	-0.9	-2.0	-1.2	-1.4	-1.5	-0.7
Neuroticism (Nagel 2018)	0.4	0.9	2.2	-1.0	-1.3	0.2	-0.5	1.5	-0.0	-0.9
Schizophrenia (2018)	5.1	10.6	26.6	5.2	1.3	4.4	3.8	-0.7	3.1	-1.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.6	0.0	-1.3	-0.2	0.0	-0.7	-0.3	0.6
Worry (Nagel 2018)	0.7	1.6	4.3	1.3	0.3	2.1	1.0	-0.0	1.5	-1.3
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	-0.4	0.8	-0.6	-0.3	0.7	-0.5	-0.1
Alzheimer’s Disease (in father)	2.8	3.0	6.3	0.4	-1.8	-1.4	-1.6	-1.6	-2.1	-2.5
Alzheimer’s Disease (including proxy)	0.8	1.1	3.3	-0.2	0.1	-1.4	-0.8	-0.7	-1.8	-1.2
Crohns Disease (2017)	0.8	1.7	5.9	0.6	0.4	0.3	1.6	1.5	0.6	2.4
Irritable Bowel Disease (IBD)	0.5	1.1	3.7	1.0	-0.1	-0.1	1.4	1.2	0.3	1.9
Ulcerative Colitis (UC)	0.2	0.4	0.9	0.9	-0.3	-0.7	0.6	0.6	-0.0	1.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.3	0.5	1.4	-0.3	-1.2	0.3	0.4	-0.7	0.7	-0.8
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.0	-0.6	-0.0	-1.4	-0.9	-0.9	-1.3	-1.1
Breast Cancer	1.5	3.5	8.2	-2.9	-0.1	-2.2	-2.5	1.1	-2.0	-0.1
Ovarian Cancer	0.9	1.1	2.8	-1.1	-1.7	-0.4	-0.4	-0.8	-1.1	-1.4
Prostate Cancer	8.0	11.2	22.6	-4.5	-2.9	-4.8	-3.1	-0.1	-4.1	0.8
Age at First Birth	0.1	0.2	0.4	0.2	0.4	-0.2	-0.3	0.5	-0.7	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.1	2.8	5.7	-2.4	-0.5	-1.7	-2.0	0.2	-2.1	-1.6
Coronary Artery Disease (CAD)	0.0	0.0	0.2	0.0	0.3	0.0	0.4	-0.2	0.0	0.1
Crohns Disease (2012)	1.1	1.8	5.4	-1.2	-1.1	-1.7	-0.2	1.2	-0.6	2.3
Mean Putamen Volume	1.5	1.7	3.3	1.1	1.8	1.8	1.4	-0.1	1.4	0.1
Fasting Glucose	0.6	0.8	2.0	-0.2	-0.7	1.2	0.1	-1.1	1.4	-0.5
HbA1C	0.1	0.1	0.2	-0.3	0.2	-0.4	0.3	0.3	0.2	0.5
HDL Cholesterol	0.6	1.0	1.8	1.1	1.3	1.3	0.7	-0.9	0.9	-0.2
LDL Cholesterol	1.1	1.8	4.5	0.3	0.1	1.5	0.4	-1.8	1.6	-2.1
Lupus	1.0	1.5	3.5	-1.4	-1.9	-1.2	-1.4	-1.0	-0.9	-0.1
Neuroticism (2016)	1.7	2.4	6.2	-1.9	-0.1	-1.5	-2.5	1.0	-1.6	-1.0
Primary Biliary Cirrhosis	1.2	1.7	5.4	0.8	-0.7	1.2	2.3	0.4	1.1	1.6
Rheumatoid Arthritis	0.4	0.5	1.2	0.8	-0.1	1.1	0.8	0.4	1.1	0.4
Schizophrenia (2014)	5.5	12.1	25.3	4.8	1.4	5.0	4.1	-1.1	3.9	-1.2
Triglycerides	0.2	0.3	1.0	-0.3	-1.0	0.5	0.0	0.8	0.6	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.0	0.1	-0.3	-0.7	-0.2	-0.4	-0.4
Ulcerative Colitis	0.3	0.4	2.0	0.6	-1.4	-0.3	-0.3	0.6	-0.2	0.2
Blood Eosinophil Count	0.4	3.4	5.9	-2.1	-2.0	-2.4	-1.7	0.4	-2.3	0.7
Blood Platelet Count	0.1	1.6	6.1	1.6	0.2	-1.3	-0.6	-0.6	-0.4	-2.5
Blood Red Count	0.2	1.6	4.9	-0.4	-0.5	0.7	-0.6	-2.2	-0.2	-2.2
Blood White Count	0.2	1.3	4.9	0.3	-1.4	-0.5	-1.2	2.2	-0.4	-0.2
Heel T-Score	0.5	3.9	11.3	1.1	3.4	2.2	2.2	-0.0	2.2	-0.2
BMI	1.3	7.6	16.5	-3.6	-2.1	-4.1	-2.8	1.8	-2.9	-0.2
Height	1.7	32.7	77.4	-8.8	-3.5	-6.7	-7.2	0.8	-6.1	2.1
Waist Hip Ratio (WHR)	0.6	2.7	7.3	2.7	-0.3	2.4	1.2	-1.3	1.5	-0.6
Systolic Blood Pressure	0.3	1.7	6.8	-1.1	2.6	0.1	-1.2	-0.9	-0.2	-1.2
Smoking Status	0.4	1.0	4.1	-0.5	-2.0	-0.2	0.8	-0.8	-0.9	-0.3
Allergy or Eczema	0.1	0.4	0.7	0.8	0.3	0.5	0.7	-0.4	0.8	0.2
Cardiovascular Disease	0.7	2.2	3.1	-1.5	1.2	-1.7	-0.9	-1.6	-1.6	-1.8
Hypothyroidism (self reported)	0.4	1.0	3.0	-0.2	-0.3	-1.1	0.1	1.7	-1.0	1.4
Respiratory disease	2.2	4.9	9.9	-2.3	-1.3	-2.8	-3.1	0.2	-2.9	-1.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.1	-0.3	0.3	-0.4	-0.7	0.4	-0.2
Lung FEV1/FVC ratio	0.3	1.5	4.0	0.8	0.4	1.3	-0.5	-2.0	-0.2	-2.0
Lung FVC	0.2	1.1	2.6	1.6	0.8	1.0	1.2	0.0	0.2	-1.5
Neuroticism	0.3	0.8	1.6	-1.3	-0.7	0.8	0.1	1.1	1.1	-0.4
Chronotype (morning person)	0.3	0.7	2.8	-0.9	-0.3	-0.9	0.1	-1.7	-0.2	0.3
Hair Pigment	0.1	3.8	7.7	-1.2	-2.8	-2.7	-1.3	-1.6	-2.5	-0.4
Tanning	0.3	4.2	9.6	-2.3	-1.0	-2.6	-2.4	0.8	-3.1	-0.6
Hand grip strength (left)	2.4	6.4	12.2	-2.8	-1.9	-2.6	-3.3	-1.2	-3.5	-1.6
Number of treatments/medications taken	0.5	0.9	2.1	-0.8	0.4	-1.5	-1.2	0.4	-1.4	-0.6
Average weekly spirits intake	0.3	0.4	0.8	-0.8	0.4	-0.3	-0.9	0.7	0.2	0.6
Sensitivity / hurt feelings	1.9	3.3	9.4	-3.0	0.3	-0.9	-1.0	3.1	0.5	1.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	-0.4	-0.4	-0.5	-0.2	1.1	-0.6	0.4
Hearing difficulty/problems: Yes	1.2	1.8	4.7	-1.8	-0.4	-1.1	-2.2	1.6	-0.3	0.5
Relative age of first facial hair	1.8	3.7	9.8	2.2	0.1	3.1	2.4	-0.1	2.2	0.9
Other serious medical condition/disability diagnosed by doctor	3.5	4.5	9.0	3.0	1.1	2.2	2.4	1.3	2.9	1.0
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.7	0.8	-0.1	-0.1	-0.1	-0.1	-0.1	-0.5
Ever had hysterectomy (womb removed)	0.7	0.8	2.8	1.7	0.4	1.2	0.9	-0.4	0.6	-0.4
Systolic blood pressure, automated reading	0.4	1.1	3.9	-2.0	1.0	-0.6	-1.2	-0.8	-0.5	-0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.4	-1.1	-0.3	-1.5	-0.7	-0.2	-0.9	-0.2
Angina	1.4	1.8	6.1	-0.8	-0.4	-2.5	-1.7	0.0	-1.6	0.1
Medication for hormone replacement therapy	0.7	0.8	2.2	-0.4	0.7	-1.0	-0.5	1.0	-1.5	0.5
Vitamin and mineral supplements	0.2	0.2	0.6	-0.2	-0.0	0.7	0.5	-0.5	0.6	-0.1
Supplements: Zinc	0.3	0.3	1.0	-1.0	-0.1	-0.3	-0.4	0.8	-0.5	0.4
Medication: Co-codamol	3.6	4.2	9.4	2.9	0.5	2.4	2.0	1.1	3.1	0.6
Medication: Metformin	0.2	0.2	0.6	-0.2	0.3	0.2	-0.7	-0.8	0.1	-0.6
Diabetes (father)	2.0	2.4	6.3	2.5	0.5	2.0	1.5	0.7	1.8	0.7
Diabetes (mother)	0.8	1.0	2.5	1.4	-0.3	1.0	1.1	-0.5	1.6	0.4
Severe depression (siblings)	0.6	0.7	1.7	-0.2	-0.9	-0.2	1.0	0.5	0.8	1.3
Pack years adult smoking proportion	0.5	0.7	4.0	0.5	-2.0	-0.4	-0.4	0.0	0.2	0.4
Impedance of leg (right)	0.7	3.4	6.7	2.6	-0.3	2.0	1.9	1.1	1.6	2.3
Leg fat-free mass (left)	2.0	10.7	27.1	-5.2	-1.5	-4.4	-4.0	-0.0	-3.2	-0.1
Trunk fat percentage	1.7	6.8	11.7	-3.1	-2.9	-3.4	-3.2	1.2	-2.3	0.7
Hand grip strength (right)	1.4	3.9	9.5	-1.7	-1.2	-2.7	-1.8	-1.2	-3.1	-1.0
Townsend deprivation index at recruitment	1.1	1.6	3.2	1.2	-0.7	0.9	1.7	-0.5	1.8	1.4
Current tobacco smoking	0.3	0.6	1.9	-0.1	-0.5	0.6	1.4	-1.0	0.5	-0.4
Average weekly fortified wine intake	0.4	0.5	1.3	-0.8	0.1	-1.1	-0.0	-1.1	-0.6	-0.2
Maternal smoking around birth	0.1	0.2	0.5	0.5	-0.7	0.2	-0.3	-0.4	0.0	0.3
Fed-up feelings	0.3	0.5	2.5	-0.7	-1.6	0.1	0.2	0.3	-0.3	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	-0.7	-0.5	-0.6	-0.4	1.1	-0.9	0.5
Relative age voice broke	0.4	0.6	2.1	1.5	-0.5	1.0	0.5	-0.5	0.4	-0.0
Taking other prescription medications	0.6	1.0	2.9	-0.8	0.1	-1.2	-1.2	1.7	-0.5	-0.6
Age when periods started (menarche)	0.2	0.5	1.9	0.8	-0.0	0.7	0.2	-0.2	0.4	1.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.8	0.7	-0.5	0.8	0.9	1.4	1.6	1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.0	8.3	1.3	2.4	2.6	2.4	-0.1	2.9	0.4
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	4.3	-1.5	-0.5	-1.2	-2.1	-0.8	-1.9	-1.4
Qualifications: CSEs or equivalent	0.6	0.8	1.7	0.9	1.0	0.3	1.3	0.7	1.1	0.7
Serious illness, injury or assault to yourself	1.0	1.2	4.0	-1.2	-1.1	-2.0	-1.0	0.3	-1.0	0.1
High blood pressure	0.7	1.9	3.7	-1.4	-0.1	-1.9	-1.0	-1.0	-1.7	-1.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	0.7	1.0	0.7	0.8	0.6	0.7	0.8
Multivitamins +/- minerals	0.4	0.5	1.1	-0.8	-0.3	-0.9	-1.0	-0.3	-1.0	0.4
Stomach or abdominal pain in last month	1.9	2.4	5.5	2.3	0.4	2.3	1.5	-0.5	1.8	-0.2
Supplements: Glucosamine	0.8	1.0	2.6	-1.6	-1.6	-1.0	-0.8	0.1	-0.6	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.6	0.8	-0.1	0.4	0.3	0.3	0.3	0.3
Medication: Atenolol	2.3	2.9	5.3	-1.1	0.6	-1.6	-1.4	-2.1	-2.2	-2.3
Medication: Levothyroxine sodium	1.0	1.7	4.2	-0.6	-1.5	-1.4	-0.1	2.0	-0.8	1.7
Sitting height	2.0	14.4	39.6	-6.3	-3.1	-3.5	-4.4	-2.1	-3.9	-0.4
Chronic bronchitis/emphysema (father)	1.2	1.4	2.8	1.4	1.7	0.7	1.3	1.6	0.7	0.4
High blood pressure (mother)	0.8	1.1	3.8	-1.2	-2.0	-1.2	-0.8	-0.2	-0.8	-0.0
Body mass index (BMI)	1.0	4.3	12.2	-2.4	-0.9	-3.5	-2.0	0.9	-2.4	-0.5
Impedance of leg (left)	0.7	3.3	7.8	2.8	-0.5	2.1	2.0	0.8	1.1	2.1
Leg predicted mass (left)	2.0	10.8	27.3	-5.2	-1.4	-4.4	-4.0	0.1	-3.2	-0.1
Trunk fat mass	2.6	11.1	20.1	-4.4	-3.0	-4.5	-4.0	1.4	-3.3	0.9
Waist circumference	1.5	5.6	13.8	-2.7	-1.7	-3.7	-2.6	0.2	-2.9	-0.4
Number of incorrect matches in round	0.2	0.3	1.1	-0.5	-1.0	-0.3	0.4	0.7	-0.5	0.4
Past tobacco smoking	1.1	2.0	9.1	0.9	3.0	1.3	0.1	-0.1	1.4	-0.5
Alcohol usually taken with meals	0.5	0.8	2.2	-1.0	0.0	-1.5	-0.5	0.3	-1.4	0.2
Nervous feelings	0.8	1.4	2.3	0.9	0.9	1.5	0.7	-1.1	1.5	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	0.6	-0.7	0.2	0.1	0.3	0.0	-0.2
Hearing difficulty/problems with background noise	2.2	3.6	8.7	-2.5	-0.5	-2.2	-3.0	-0.3	-1.9	-1.1
Hair/balding pattern: Pattern 2	1.1	1.4	3.9	-0.2	-0.5	-1.2	-1.1	2.0	-1.0	1.4
Had menopause	0.6	0.7	2.8	-0.8	-1.7	-0.9	-0.2	-0.3	-0.8	0.3
Had other major operations	0.8	1.0	5.1	0.3	-2.2	-0.0	-0.2	-0.7	-0.9	-0.8
Forced vital capacity (FVC)	0.2	0.6	1.6	-1.1	-0.3	-0.6	-0.7	-0.6	-1.3	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	6.4	1.1	2.1	2.5	2.4	-0.8	2.4	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.0	0.0	0.3	-0.1	-0.8	0.0	-0.8
Qualifications: None of the above	0.4	0.9	3.0	-0.4	-1.7	-1.3	-0.1	-1.1	-0.9	-0.1
Financial difficulties in last 2 years	0.2	0.3	0.9	-0.5	-0.7	-0.4	-0.6	0.9	-0.3	-0.1
Mouth/teeth dental problems	0.3	0.5	2.4	-0.2	-1.6	-0.2	-0.3	0.1	-0.3	0.9
Heart attack	2.0	2.5	5.6	-2.1	-0.4	-2.4	-1.6	-0.3	-2.2	-0.2
Allergy	0.4	0.9	1.8	0.7	-0.4	1.3	1.3	-0.6	1.4	-0.1
Pain all over the body in last month	0.7	0.8	2.8	0.5	-1.2	-0.4	-0.1	1.7	0.3	0.9
Diabetes (self-reported)	0.1	0.1	0.4	0.2	-0.2	0.2	0.4	0.1	0.7	0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.8	0.7	0.6	0.6	0.5	0.7	0.4	1.4
Medication: Ramipril	0.3	0.3	0.9	1.0	-0.5	-0.6	0.4	-0.6	-0.3	0.1
Medication: Simvastatin	0.5	0.7	3.4	0.4	-0.3	-0.4	-0.4	-0.8	-0.3	-1.8
Fluid intelligence score	0.7	1.4	3.9	-0.0	-1.3	-0.8	-0.9	-1.4	-0.6	-2.0
Illnesses of siblings	1.5	2.1	4.8	1.4	0.7	2.2	1.8	0.3	1.8	0.9
Neuroticism score	0.3	0.6	1.6	-1.3	-0.5	0.4	-0.6	0.9	0.5	-0.9
Weight	2.6	12.8	25.2	-5.0	-2.5	-5.0	-4.1	0.6	-4.0	0.3
Impedance of arm (right)	0.5	2.2	4.8	1.4	-0.5	2.2	0.7	0.3	2.0	2.0
Arm fat percentage (right)	1.1	4.3	10.4	-2.6	-1.5	-3.2	-2.3	1.5	-1.8	0.4
Trunk fat-free mass	2.1	12.0	29.1	-5.4	-1.0	-4.8	-3.8	-0.0	-4.2	-0.0
Hip circumference	2.9	12.3	30.0	-4.8	-2.0	-5.5	-3.7	0.3	-4.0	-0.0
Time employed in main current job	0.2	0.3	0.6	-0.5	0.8	0.3	-0.3	0.5	0.1	0.8
Alcohol intake versus 10 years previously	1.0	1.5	3.2	1.5	-1.5	0.6	1.1	1.8	0.7	1.0
Father’s age at death	0.2	0.2	1.0	-0.1	-1.0	0.1	-0.0	0.4	0.0	0.5
Worrier / anxious feelings	0.7	1.4	5.2	0.5	0.1	1.7	0.5	-0.7	0.6	-2.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	-1.2	-0.3	-0.8	-1.0	0.5	-0.0	-0.8
Falls in the last year	0.2	0.3	0.9	-0.1	0.6	0.1	0.9	0.0	1.0	-0.4
Hair/balding pattern: Pattern 3	0.5	0.7	3.2	-0.8	0.3	0.1	-0.6	-0.8	-0.0	-1.8
Number of live births	6.2	8.8	17.3	4.2	2.3	3.3	3.2	0.8	4.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.3	-0.5	0.6	-0.1	-0.8	-1.1	-1.1	-0.9
Pulse rate	0.2	0.4	1.0	1.0	0.7	0.0	0.5	0.6	0.8	0.4
Happiness	0.3	0.4	1.0	-0.3	-0.5	-0.3	-0.7	1.0	0.3	0.7
Noisy workplace	0.2	0.3	1.0	-1.0	0.0	-0.6	0.1	-0.7	-0.1	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	0.2	-0.7	-0.3	-0.1	-0.6	-0.6	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.4	-1.2	-0.5	-0.4	-0.2	-0.1	-0.3	-0.3
Mouth/teeth dental problems: Dentures	0.5	0.8	2.0	-1.1	0.6	-1.4	-0.9	1.0	-0.7	0.1
Asthma	2.4	4.7	11.1	-1.8	-0.5	-2.9	-3.1	0.0	-3.3	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	4.2	2.0	1.6	1.5	1.0	-0.5	1.1	-0.8
Medication: Cholesterol lowering	2.1	3.2	8.3	-1.9	-0.5	-2.9	-2.2	0.3	-2.3	-0.7
Depression (self-reported)	1.8	2.2	4.9	2.0	0.6	2.2	0.9	0.1	2.0	-0.8
Medication: Lansoprazole	1.2	1.4	3.0	-1.5	-1.4	-1.3	-0.5	1.7	0.1	0.8
Prospective memory result	0.3	0.3	1.3	-0.3	-0.6	-0.0	0.2	0.5	-0.5	1.2
Lung cancer (father)	2.3	2.7	6.3	-1.6	-2.5	-2.1	-1.9	-0.7	-1.2	-0.6
Illnesses of mother	0.4	0.5	1.2	1.0	1.1	0.9	0.3	0.2	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.6	0.3	1.2	0.7	-0.3	-0.8	-0.4	-0.9
Pulse wave Arterial Stiffness index	0.7	0.8	1.3	-1.0	-0.5	-1.0	-0.4	-0.9	-1.1	-1.1
Impedance of arm (left)	0.6	2.7	6.8	1.5	-1.5	2.6	0.7	-0.1	2.2	1.5
Arm fat mass (right)	1.7	7.1	16.6	-3.5	-1.8	-4.1	-2.8	1.4	-2.8	0.5
Trunk predicted mass	2.2	12.3	29.7	-5.5	-1.0	-4.9	-3.8	0.1	-4.2	0.1
Standing height	1.5	15.2	38.3	-6.2	-3.5	-3.9	-4.8	-0.7	-3.9	1.6
Length of working week for main job	1.1	1.2	2.6	1.6	-0.6	1.1	1.2	1.4	0.9	0.5
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.3	-0.1	-0.4	0.2	0.4	-0.2	-0.1
Breastfed as a baby	1.3	1.7	3.0	-1.6	-1.7	-1.5	-1.2	0.5	-1.1	-0.8
Tense / ‘highly strung’	0.3	0.6	2.2	-1.2	0.2	0.2	-0.4	-0.3	-0.3	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.9	0.4	-1.4	0.7	-0.0	0.5	0.9	-1.1
Hair/balding pattern: Pattern 4	0.6	1.5	4.1	-0.5	-0.5	-2.0	-1.6	0.3	-1.9	-0.2
Birth weight of first child	1.5	2.8	6.0	-2.3	0.3	-1.8	-2.2	-0.2	-2.5	-0.3
Peak expiratory flow (PEF)	0.4	1.0	3.0	0.1	1.2	1.1	-0.0	-1.7	0.7	-1.0
Pulse wave reflection index	1.2	1.5	4.1	-0.1	-1.6	-0.6	-0.1	-2.0	-0.7	-1.8
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.6	-1.7	-1.3	-1.7	-1.9	-0.1	-1.4	-0.3
Loud music exposure frequency	1.9	2.0	4.9	-2.2	-0.8	-1.8	-1.8	0.2	-1.4	-0.1
Qualifications: O levels/GCSEs or equivalent	2.2	3.6	9.1	3.0	0.7	2.5	2.4	-0.2	1.8	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.2	0.0	0.0	0.6	0.3	-0.1	0.4
Blood clot in the leg (DVT)	0.9	1.2	3.1	-1.0	-0.4	0.6	-0.3	1.7	0.9	1.8
Medication: Paracetamol	0.0	0.1	0.2	-0.3	0.2	0.0	0.4	-0.2	0.4	0.0
Headache pain in last month	0.1	0.2	0.5	0.7	0.4	0.3	0.5	-0.5	0.5	-0.1
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	5.7	2.0	1.0	2.4	2.4	-0.0	2.0	1.4
Glaucoma (self-reported)	1.1	1.3	4.6	-0.8	-0.9	-0.4	-0.3	1.4	0.8	2.2
Gout (self-reported)	1.1	1.5	4.2	-1.2	-0.7	-2.0	-0.9	1.3	-1.4	0.4
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.8	-0.3	-0.9	-1.3	-0.5	1.1	-1.3	0.8
Medication: Amlodipine	1.3	1.8	3.9	-1.7	-0.4	-1.3	-2.0	-0.5	-1.7	-0.8
Medication: Ventolin 100micrograms inhaler	4.1	5.2	11.1	-2.5	-1.0	-2.8	-3.2	0.3	-3.3	-0.2
Birth weight	6.0	12.9	20.3	-2.5	-4.5	-4.3	-4.1	-2.0	-4.2	-2.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.5	-0.6	-0.1	-0.9	-0.0	1.0	-0.9	1.6
High blood pressure (siblings)	1.9	2.7	5.2	-1.6	-0.7	-2.0	-1.6	-1.0	-2.3	-1.8
Forced vital capacity (FVC), Best measure	0.1	0.4	1.2	-0.7	0.5	-0.5	-0.6	-0.5	-1.1	-0.4
Body fat percentage	1.5	5.8	11.2	-2.7	-2.7	-3.3	-2.7	1.6	-2.1	0.8
Leg fat percentage (right)	1.1	4.2	10.4	-2.2	-1.8	-3.2	-1.9	1.9	-1.7	0.8
Arm fat-free mass (right)	2.2	11.5	23.4	-4.8	-1.8	-4.7	-3.8	-0.2	-4.1	-0.3
Exposure to tobacco smoke outside home	0.9	1.2	3.9	2.0	-0.7	1.3	-0.0	-0.8	-0.2	-1.3
Comparative body size at age 10	0.5	1.4	4.3	-1.0	0.5	-2.1	-0.6	0.1	-2.0	-0.1
Number of full brothers	2.4	3.0	6.3	2.5	-1.5	1.6	2.0	-2.1	1.1	-0.3
Worry too long after embarrassment	0.7	1.2	3.0	-0.8	-1.6	-0.4	-1.7	1.5	-0.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.2	1.7	-0.2	1.1	1.8	1.5	1.3	0.9
Wheeze or whistling in the chest in last year	1.7	3.1	6.5	-1.3	-1.9	-2.4	-1.8	-0.6	-2.6	-0.1
Number of children fathered	1.4	1.6	4.1	-1.4	-0.3	-2.0	-1.5	0.2	-1.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.7	-1.2	-0.5	-1.3	-1.2	1.0	-0.8	0.3
Age at first live birth	0.8	1.4	4.0	-2.0	-0.8	-1.3	-0.9	-0.3	-1.4	-1.0
Pulse wave peak to peak time	0.5	0.6	1.6	0.7	0.1	0.8	0.1	0.8	1.0	1.3
Health satisfaction	0.7	0.9	4.8	0.8	2.2	-0.0	0.0	-0.5	-0.3	-0.9
Shortness of breath walking on level ground	0.1	0.1	0.5	-0.5	0.3	-0.7	-0.1	0.4	-0.2	0.1
Qualifications: College or University degree	0.3	1.0	4.1	2.0	0.4	1.4	0.8	-0.1	0.6	0.3
Eye problems/disorders: None of the above	0.2	0.2	0.8	0.4	-0.3	-0.1	0.0	-0.5	-0.9	-0.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.1	1.0	1.5	1.1	1.4	-0.1	0.4	-1.2
Emphysema/chronic bronchitis	1.6	1.8	5.0	-0.6	2.2	-1.6	-1.4	-0.2	-1.6	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	-0.9	-0.3	-0.3	-0.1	0.8	-0.7	0.2
Neck or shoulder pain in last month	0.5	0.7	1.6	-0.1	1.2	-0.5	-0.4	0.1	-1.0	-1.3
Medication: Blood pressure	1.7	3.0	6.7	-2.2	-0.4	-1.4	-2.6	-0.6	-1.4	-2.1
Angina (self-reported)	1.4	1.9	6.1	-0.9	-0.6	-2.5	-1.8	0.0	-1.7	0.1
Migraine (self-reported)	0.5	0.6	1.2	1.1	1.0	-0.4	-1.0	0.9	-0.1	-0.1
Medication: Ibuprofen	0.6	0.7	1.7	1.2	1.3	0.9	0.3	0.0	0.7	-0.4
Medication: Allopurinol	0.8	1.1	2.5	-1.6	-1.0	-1.2	-1.0	1.2	-0.6	0.4
Medication: Omeprazole	0.2	0.3	1.2	1.1	0.5	0.2	-0.1	-0.5	-0.1	-0.4
Medication: Seretide 50 evohaler	0.6	0.7	2.0	-0.1	0.0	-0.9	-1.4	-0.6	-1.0	-0.7
Mean time to correctly identify matches	0.6	1.1	3.1	-1.7	-1.8	-0.8	-0.5	-0.4	-0.6	-0.8
Heart disease (mother)	0.9	1.0	1.7	-0.2	-1.2	-0.8	-1.3	-1.1	-0.9	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.7	1.2	0.6	1.2	-0.1	-1.6	0.5	-1.5
Whole body fat mass	2.3	9.5	18.7	-4.0	-2.6	-4.3	-3.5	1.6	-3.1	0.7
Leg fat mass (right)	1.9	7.3	17.3	-3.5	-1.8	-4.2	-2.8	1.5	-2.8	0.6
Arm predicted mass (right)	2.2	11.1	23.6	-4.9	-1.4	-4.8	-3.6	-0.0	-4.1	0.0
Pulse rate, automated reading	0.4	1.2	3.2	1.1	0.8	1.4	-0.0	1.1	1.8	-0.2
Alcohol intake frequency.	0.2	0.5	1.2	0.9	-0.1	0.2	0.9	0.1	1.1	0.8
Comparative height size at age 10	2.8	15.5	31.1	-5.6	-3.5	-4.2	-4.9	-0.7	-4.7	1.2
Number of full sisters	0.7	0.9	2.8	-0.9	-0.0	-1.0	0.5	0.9	-0.6	1.7
Suffer from ‘nerves’	0.5	0.8	1.6	-1.3	-0.6	-1.0	-1.0	0.4	-0.8	-1.0
Overall health rating	1.2	2.6	5.3	2.3	1.5	1.7	1.7	0.5	2.2	-0.1
Chest pain or discomfort	0.3	0.5	1.2	1.1	-0.7	-0.3	0.1	-0.6	-0.5	-0.9
Had major operations	0.2	0.2	0.4	-0.5	-0.1	-0.5	-0.5	0.4	-0.5	0.6
Age at last live birth	0.1	0.1	0.7	-0.4	-0.8	0.1	0.3	0.0	0.2	0.2
Family relationship satisfaction	0.6	0.7	2.2	0.3	-0.1	-0.0	-0.2	1.5	1.0	1.3
Leg pain on walking	0.3	0.4	1.5	-0.3	-0.6	-0.7	-0.7	1.2	-0.0	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.9	-1.2	1.7	-0.3	-0.6	1.6	-0.2	0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.5	2.7	-0.4	0.4	-1.6	-0.5	0.2	-0.7	0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.5	-0.2	0.4	-0.6	-0.2	-0.5	-0.3
Medication: Aspirin	1.4	1.9	3.9	-1.2	0.0	-2.0	-1.9	-0.7	-1.8	-0.7
Supplements: Vitamin C	1.1	1.3	2.8	0.3	-1.1	-1.3	-1.1	-0.4	-1.4	-1.7
Knee pain experienced in last month	0.8	1.3	3.9	-0.3	0.8	-0.7	-1.1	-0.7	-1.5	-2.0
Hypertension (Self-reported)	0.7	2.0	5.3	-1.3	0.6	-1.4	-0.9	-1.3	-1.3	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.2	-0.2	0.1	-0.2	1.1	0.6	-0.1	0.6
Illnesses of father: Heart disease	0.8	1.0	4.4	0.2	-0.5	-0.6	-0.7	-1.2	-0.5	-2.1
Illnesses of siblings: Diabetes	0.6	0.7	1.4	-1.1	-1.2	-0.4	-1.1	0.6	-0.6	0.1
Smoking status: Previous	1.1	1.7	5.6	-0.9	-2.4	-1.5	-0.5	0.3	-1.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	6.1	-2.4	-2.5	-1.2	-1.9	-0.6	-0.7	1.1
Whole body fat-free mass	2.1	11.9	29.1	-5.4	-1.2	-4.7	-3.9	-0.1	-3.9	-0.1
Leg fat-free mass (right)	1.8	9.8	24.4	-4.9	-1.3	-4.1	-3.9	-0.4	-3.3	-0.3
Arm fat percentage (left)	1.1	4.5	9.4	-2.6	-2.1	-3.1	-2.4	1.3	-1.8	0.1
Average weekly red wine intake	0.4	0.5	1.2	-0.1	-0.4	-0.9	0.4	-0.6	-1.1	-0.9
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.8	-1.5	-1.3	-0.7	-1.7	-0.4	-1.2	-0.7
Mood swings	0.3	0.6	1.3	-0.4	-0.4	-0.7	-0.6	0.7	-1.1	-1.0
Loneliness, isolation	0.6	0.9	2.3	-1.5	0.3	-0.1	-1.2	0.4	-0.0	-1.5
Long-standing illness, disability or infirmity	0.6	0.9	2.1	1.2	1.4	0.4	0.6	0.9	1.1	0.4
Ever had bowel cancer screening	0.4	0.4	1.5	-1.2	0.7	0.3	-0.4	0.2	-0.0	-0.9
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.2	0.0	0.5	0.2	0.1	0.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.6	1.5	1.2	1.6	0.3	-0.5	0.5	-1.3
Friendships satisfaction	0.3	0.4	1.4	-0.5	-0.4	-0.2	-1.2	-0.5	-0.3	-0.6
Qualifications: nursing, teaching	0.0	0.1	0.2	0.4	0.3	0.2	0.1	-0.4	0.2	0.1
Commuting to job workplace: Walk	3.2	3.4	7.5	2.0	1.3	2.7	2.0	-1.2	2.3	-0.3
Eye problems/disorders: Cataract	1.8	2.0	3.0	1.7	1.0	1.1	1.5	1.0	1.7	1.7
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	11.5	0.0	0.8	1.6	0.2	-3.4	1.5	-2.0
Medication for cholesterol	0.7	1.0	3.7	-0.1	-1.9	0.4	-0.6	0.6	-0.0	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.1	6.5	2.5	1.4	2.5	0.8	-0.5	2.4	-0.5
Back pain experienced in last month	0.6	0.9	3.0	0.8	1.7	-0.3	-0.2	1.1	-0.4	-0.9
Mineral and other dietary supplements	0.3	0.5	1.9	1.4	0.1	0.7	0.8	0.0	0.5	-0.1
Breast cancer (self-reported)	2.4	2.9	9.0	3.0	-0.3	1.8	2.0	-1.4	1.5	-0.1
Asthma (self-reported)	2.9	5.8	13.7	-2.1	-0.8	-3.3	-3.2	0.3	-3.7	-0.7
Osteoporosis (self-reported)	0.5	0.6	1.3	0.7	1.1	0.2	0.8	0.8	0.2	0.9
Osteoarthritis (self-reported)	0.6	0.8	1.9	0.4	-0.8	-1.4	-0.5	0.8	-0.6	-1.4
Medication: Aspirin	2.8	3.7	7.4	-2.1	-1.0	-2.7	-2.5	-0.4	-2.5	-0.6
Medication: Gliclazide	0.7	0.8	1.8	-1.0	-1.2	-0.8	-1.3	0.3	-0.4	0.6
Illnesses of father: None of the above (group 1)	1.2	1.4	3.1	1.2	-0.2	1.5	1.7	-0.1	1.5	1.0
Smoking status: Current	0.4	0.7	1.7	-0.1	-0.9	0.4	1.1	-1.3	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.6	1.2	1.6	1.3	0.5	-0.8	0.4	-0.6
Whole body water mass	2.0	11.5	28.3	-5.3	-1.2	-4.7	-3.8	0.0	-3.9	-0.0
Leg predicted mass (right)	1.8	9.7	24.2	-4.9	-1.3	-4.0	-3.8	-0.4	-3.3	-0.3
Arm fat mass (left)	2.0	8.0	17.7	-3.8	-2.0	-4.2	-3.1	1.3	-2.9	0.4
Number of self-reported non-cancer illnesses	0.2	0.4	1.3	0.9	0.5	0.0	0.3	0.5	0.2	-1.1
Average weekly champagne plus white wine intake	0.9	1.2	2.5	-1.6	0.5	-1.2	-1.2	0.9	-1.4	0.4
Miserableness	0.6	1.1	1.8	-1.3	-1.3	-1.3	-0.8	-0.3	-1.2	-0.8
Guilty feelings	0.6	0.9	5.2	-0.0	-0.1	0.6	0.5	2.3	0.3	0.4
Wears glasses or contact lenses	3.1	3.6	8.9	-3.0	-0.6	-1.5	-2.8	-0.6	-1.5	-1.8
Ever taken oral contraceptive pill	0.7	0.8	2.6	0.5	-0.8	0.9	0.0	1.1	0.5	1.6
Hearing aid user	0.4	0.4	1.4	-0.0	-1.2	0.1	0.1	-0.4	1.0	0.8
Mother’s age at death	1.2	1.5	4.2	-2.1	-1.2	-1.6	-1.0	0.6	-1.0	0.5
Financial situation satisfaction	0.4	0.5	1.2	-0.1	-0.5	0.0	-1.1	-1.1	0.1	-0.9
Tinnitus: Yes, now most or all of the time	2.8	3.3	9.1	-2.5	-3.0	-1.6	-1.9	0.3	-1.1	0.1
Commuting to job workplace: Public transport	0.5	0.7	1.7	0.0	-1.0	1.3	0.3	0.1	1.3	-0.0
Eye problems/disorders: Glaucoma	1.2	1.4	2.6	-1.6	-1.1	-1.5	-1.2	1.1	-0.5	0.9
Medication: Blood pressure	1.0	2.0	5.0	1.3	1.6	0.4	2.2	-1.6	0.5	-1.2
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.2	0.2	0.8	-1.1	-1.0	-0.6	-0.9	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.3	-1.2	1.5	-0.8	-1.0	0.5	-0.4	0.3
High cholesterol (Self-reported)	0.7	1.3	2.9	-0.7	1.7	-1.6	-0.7	-0.3	-0.5	-1.4
Medication: Bendroflumethiazide	0.3	0.5	2.4	-0.7	0.1	-0.2	0.2	-0.3	0.4	-1.6
Medication: Paracetamol	0.1	0.1	0.4	0.0	0.0	0.2	0.2	0.1	0.5	0.7
Medication: Lisinopril	0.6	0.8	3.1	-1.8	0.4	-1.2	-0.7	0.4	-0.1	0.0
Medication: Atorvastatin	2.0	2.5	6.4	-1.8	0.8	-2.5	-1.8	0.2	-1.7	-1.1
Illnesses of father: High blood pressure	1.1	1.4	3.6	-1.5	-0.4	-0.3	-0.9	1.9	-0.0	1.7
Alcohol drinker status: Never	0.5	0.6	2.8	-0.7	1.7	-0.2	-0.8	0.3	0.0	-0.1
Ever smoked	0.8	1.3	6.1	-0.6	-2.5	-1.0	-0.3	-0.5	-1.2	0.0
Basal metabolic rate	2.1	11.5	26.3	-5.1	-1.4	-4.7	-3.9	0.1	-3.9	0.1
Leg fat percentage (left)	1.2	4.3	10.3	-2.2	-1.9	-3.2	-1.9	1.7	-2.0	0.7
Arm fat-free mass (left)	2.5	12.8	27.1	-5.1	-1.1	-5.2	-3.9	-0.1	-4.5	-0.0
Number of operations (self-reported)	0.3	0.4	1.4	0.8	-1.2	0.5	0.4	0.5	-0.1	-0.2
Average weekly beer plus cider intake	0.1	0.2	0.6	0.8	-0.3	-0.5	-0.2	0.4	-0.5	0.2
Irritability	1.2	2.0	4.9	-2.2	-1.4	-0.9	-1.7	1.1	-1.2	-0.7
Risk taking	0.7	1.0	5.4	0.0	-2.3	-0.7	-0.1	-0.2	-1.0	-0.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	3.5	-1.9	-0.7	-0.1	-0.7	-0.3	-0.1	-0.3
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-0.4	-1.0	-0.8	-0.9	0.2	-1.2	-0.3
Age started oral contraceptive pill	0.4	0.5	1.3	-1.1	-0.7	-1.1	0.0	-0.3	-0.5	0.3
Diastolic blood pressure, automated reading	0.9	2.7	6.2	-2.5	-0.6	-1.8	-2.1	-0.8	-1.7	-1.0
Ever depressed for a whole week	0.1	0.1	0.4	-0.6	0.6	-0.5	-0.1	0.0	-0.2	-0.2
Unable to work because of sickness or disability	0.7	0.9	3.8	0.2	-1.4	-0.3	0.5	2.0	0.5	0.4
Commuting to job workplace: Cycle	0.3	0.4	1.2	1.1	0.5	-0.2	-0.1	-0.9	0.2	-0.4
Myopia	0.3	0.5	1.4	0.5	-0.1	0.8	0.6	0.3	1.2	0.7
Vascular/heart problems diagnosed by doctor	1.0	2.7	5.6	1.7	0.1	2.4	1.4	1.2	2.0	1.7
Cholesterol lowering medication	0.5	0.8	3.0	0.3	1.0	0.1	0.3	-0.4	1.0	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.2	0.5	-0.1	-0.0	-0.0	0.0	0.1	0.1
Pain experienced in last month	0.4	0.7	1.4	0.0	-1.2	0.9	0.9	0.3	0.9	1.0
Supplements: Calcium	0.5	0.5	2.5	0.0	1.6	0.6	-0.2	0.5	0.7	0.0
Basal cell carcinoma (self-reported)	1.0	1.2	4.0	-1.1	-0.6	-0.2	-2.0	-0.4	-1.0	-1.3
Heart attack/myocardial infarction (self-reported)	2.3	3.0	6.7	-2.2	-0.4	-2.6	-2.0	-0.2	-2.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.2	-1.2	-0.7	0.4	-0.4	1.8	0.8	1.7
Heart disease (siblings)	0.4	0.5	1.2	-0.7	-0.8	-1.1	-0.6	0.4	-0.2	1.0
Alcohol drinker status: Previous	1.1	1.3	3.0	1.7	-1.1	0.8	1.0	0.9	1.2	0.9
Pack years of smoking	0.5	0.7	3.7	0.3	-1.9	-0.6	-0.6	-0.1	-0.1	0.2
Impedance of whole body	0.7	3.3	6.5	2.3	-1.4	2.5	1.3	0.4	1.9	2.0
Leg fat mass (left)	2.0	7.6	17.7	-3.5	-1.8	-4.2	-3.0	1.4	-3.0	0.5
Arm predicted mass (left)	2.0	10.3	22.4	-4.5	-1.1	-4.7	-3.4	-0.2	-4.0	-0.0