Hub : Genes

FAM8A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0250	4.5e-04	0.070	0.022	0.037	0.043	0.058	6.2e-09	8.2e-04	2.2e-05	5.5e-06	1.4e-07
2	GTEx	Artery Tibial	0.0907	0.0366	4.7e-03	0.054	NA	0.008	NA	0.009	4.8e-05	NA	6.8e-02	NA	5.6e-02
3	GTEx	Skin Sun Exposed Lower leg	0.1100	0.0430	3.5e-03	0.014	NA	0.028	NA	0.029	2.4e-02	NA	2.1e-03	NA	1.7e-03
4	ROSMAP	Brain Pre-frontal Cortex	0.0806	0.0248	1.7e-05	0.078	0.033	0.064	0.053	0.071	3.1e-10	3.5e-05	1.2e-08	2.1e-07	2.1e-09
5	YFS	Blood	0.0527	0.0138	1.9e-10	0.038	0.039	0.042	0.043	0.046	1.9e-12	6.7e-13	1.4e-13	6.5e-14	8.6e-15
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0750	0.0480	9.8e-03	0.018	0.039	0.015	NA	0.009	3.2e-02	2.7e-03	4.2e-02	NA	9.7e-02
7	TCGA	Liver Hepatocellular Carcinoma	0.0660	0.0360	3.0e-03	-0.006	0.025	0.009	NA	0.005	9.3e-01	2.4e-02	1.1e-01	NA	1.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	1.8	0.4	1.3	0.7	0.2	-0.6	-0.4	-1.0
Bipolar Disorder or Schizophrenia	0.2	0.4	0.9	-0.3	0.8	-0.2	-0.6	0.6	-0.9	-0.5
Depressed Affect (Nagel 2018)	3.2	6.7	9.7	-2.7	-2.5	-2.5	-2.3	2.8	-2.2	3.1
Depression (Nagel 2018)	1.5	2.3	3.8	-1.8	-0.9	-1.7	-1.3	1.2	-2.0	1.5
Intelligence (Savage-Jansen 2018)	0.6	1.9	2.7	-1.6	-1.2	-1.4	-1.6	1.6	-1.3	-0.3
Neuroticism (Nagel 2018)	6.2	14.7	17.9	-4.1	-3.9	-3.8	-3.4	4.2	-3.2	4.2
Schizophrenia (2018)	0.3	0.6	1.6	-0.7	0.0	-0.8	-0.9	1.3	-0.9	0.1
Schizophrenia vs Biploar Disorder	0.5	0.6	1.5	0.6	0.8	0.3	0.6	-0.4	1.0	-1.2
Worry (Nagel 2018)	2.8	5.8	9.5	-2.3	-3.1	-2.0	-1.6	3.0	-1.3	2.9
Alzheimer’s Disease (in mother)	2.8	3.2	6.2	1.6	1.5	1.4	1.6	-2.0	1.8	-2.5
Alzheimer’s Disease (in father)	1.6	1.7	3.2	-1.3	-0.3	-1.8	-1.2	1.2	-1.3	1.4
Alzheimer’s Disease (including proxy)	2.2	3.2	4.0	1.8	1.7	1.4	1.8	-1.9	2.0	-1.8
Crohns Disease (2017)	0.1	0.1	0.5	0.4	0.7	0.2	0.0	-0.1	-0.3	-0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.4	1.2	0.3	1.1	0.6	-0.9	0.9	-0.7
Ulcerative Colitis (UC)	1.0	1.9	3.0	1.7	-0.0	1.7	1.1	-1.5	1.7	-0.8
Major Depression (MDD)	0.3	0.3	0.9	-0.0	0.8	-0.3	0.6	0.9	-0.6	0.2
Reaction Time	1.0	1.8	3.9	-1.2	-1.7	-1.2	-1.4	1.0	-0.6	2.0
Verbal and Numeric Reasoning (VNR)	1.4	3.4	5.7	-2.4	-0.8	-2.1	-2.1	2.1	-2.0	-0.1
Breast Cancer	1.3	3.2	5.2	-2.2	-0.1	-2.2	-1.8	1.6	-2.3	1.3
Ovarian Cancer	0.5	0.7	1.6	-0.8	-0.7	-0.6	-0.9	0.6	-0.6	1.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.4	1.4	-0.4	-1.2	-0.4	-0.2	0.7	0.3	0.2
Bipolar Disorder (2011)	0.5	0.5	1.2	0.9	0.2	1.0	0.3	0.0	1.1	0.6
Body Mass Index (BMI) (2010)	0.1	0.1	0.5	-0.2	-0.7	-0.3	0.3	0.1	-0.5	0.1
Coronary Artery Disease (CAD)	0.8	1.0	2.3	0.9	0.1	0.9	1.5	-1.0	1.3	-0.6
Crohns Disease (2012)	0.6	0.9	3.2	0.5	1.8	0.4	0.5	-0.8	-0.2	-1.3
Mean Putamen Volume	1.8	2.0	5.2	1.4	0.2	1.4	1.6	-1.2	2.3	-1.0
Fasting Glucose	1.6	2.0	3.9	1.1	1.2	0.9	1.8	-2.0	1.6	-0.9
HbA1C	0.6	0.7	1.1	-1.0	-0.8	-1.0	-0.5	0.9	-0.9	0.5
HDL Cholesterol	0.6	1.0	2.1	-1.2	-0.2	-1.1	-1.5	1.0	-0.7	0.8
LDL Cholesterol	0.2	0.3	1.1	-0.3	-1.1	-0.5	0.2	0.5	-0.2	0.2
Lupus	0.6	0.9	2.4	0.7	1.5	0.4	0.6	-0.5	0.8	-1.6
Neuroticism (2016)	3.1	4.5	9.6	-1.8	-3.1	-1.5	-1.8	2.3	-1.4	2.4
Primary Biliary Cirrhosis	3.0	4.3	6.5	2.3	1.1	2.1	2.3	-1.8	2.6	-2.1
Rheumatoid Arthritis	0.1	0.2	0.8	0.2	-0.1	0.1	-0.0	0.5	0.9	-0.5
Schizophrenia (2014)	0.1	0.3	0.5	0.5	0.4	0.5	0.3	0.3	0.7	-0.7
Triglycerides	0.2	0.3	0.6	-0.3	-0.5	-0.5	-0.3	0.5	-0.8	0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.4	-0.6	-0.5	-0.5	0.8	-0.3	0.8
Ulcerative Colitis	0.3	0.4	0.7	0.8	0.1	0.7	0.6	-0.7	0.7	-0.5
Blood Eosinophil Count	0.2	1.6	3.4	-1.2	-1.8	-1.1	-0.9	1.6	0.2	1.3
Blood Platelet Count	0.0	0.5	2.0	0.4	-1.4	0.5	0.5	0.7	0.3	-0.0
Blood Red Count	0.1	1.2	2.2	1.5	1.2	1.4	1.1	-1.0	0.7	-0.7
Blood White Count	0.7	5.2	9.3	2.0	3.0	1.9	2.0	-2.6	2.1	-2.1
Heel T-Score	0.2	1.6	3.9	-1.4	0.5	-1.4	-1.5	0.9	-2.0	0.1
BMI	0.3	1.6	3.0	1.7	-0.6	1.7	1.2	-0.7	1.6	0.6
Height	1.1	20.5	27.5	4.1	4.1	4.5	4.0	-4.6	5.0	-5.2
Waist Hip Ratio (WHR)	1.4	6.3	9.2	3.0	2.4	3.0	3.0	-1.8	1.9	-2.1
Systolic Blood Pressure	0.1	0.6	2.6	-0.5	-0.0	-0.6	-0.3	0.0	-1.6	-0.9
Smoking Status	1.2	2.9	4.6	2.0	2.1	2.2	1.1	-1.4	1.4	-1.4
Allergy or Eczema	1.5	4.1	7.2	-2.5	-0.3	-2.5	-2.5	1.3	-2.7	0.9
Cardiovascular Disease	0.1	0.3	0.7	0.5	0.5	0.5	0.5	-0.1	-0.8	-0.3
Hypothyroidism (self reported)	0.3	0.7	1.2	-1.0	-0.4	-1.0	-0.8	1.1	-0.8	0.4
Respiratory disease	1.1	2.5	3.7	-1.6	-1.8	-1.3	-1.9	1.7	-1.1	1.5
Type 2 Diabetes (T2D) (2018)	1.2	2.2	3.8	1.3	0.7	1.5	1.7	-1.9	1.9	-0.5
Lung FEV1/FVC ratio	0.1	0.3	0.5	0.6	-0.4	0.7	0.3	-0.3	-0.6	0.6
Lung FVC	0.0	0.1	0.8	-0.1	0.0	-0.1	0.1	-0.3	-0.9	-0.1
Neuroticism	3.2	7.7	11.6	-2.8	-2.9	-2.5	-2.2	3.4	-2.0	3.4
Chronotype (morning person)	1.0	2.2	5.7	1.4	0.8	1.3	1.8	-0.9	2.4	-1.3
Hair Pigment	0.0	0.4	1.6	0.5	0.5	0.3	0.4	-0.1	0.7	-1.2
Tanning	0.0	0.1	0.3	0.2	0.5	-0.0	0.2	-0.1	0.1	0.1
Hand grip strength (left)	0.0	0.1	0.2	-0.1	-0.1	-0.1	-0.5	0.3	-0.4	0.2
Number of treatments/medications taken	2.1	3.9	6.5	1.6	2.5	1.7	1.7	-2.1	1.5	-2.3
Average weekly spirits intake	1.3	1.7	2.9	-1.4	-1.7	-1.2	-0.9	1.7	-0.6	1.2
Sensitivity / hurt feelings	2.8	4.7	7.1	-2.5	-1.2	-2.4	-2.0	2.7	-2.3	1.8
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.0	-0.6	0.1	-0.4	-0.7	0.4	-1.4	0.3
Hearing difficulty/problems: Yes	0.3	0.4	0.9	0.3	0.7	0.5	-0.0	-0.9	-0.4	-0.9
Relative age of first facial hair	0.7	1.5	4.9	-0.9	-2.2	-1.3	-1.2	1.0	-0.4	0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.9	0.6	-0.1	0.6	0.6	-1.0	0.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.1	-0.3	-0.3	0.3	0.5	0.2	-0.3
Ever had hysterectomy (womb removed)	0.8	0.9	2.3	-1.0	-0.9	-0.7	-0.9	0.8	-1.5	0.5
Systolic blood pressure, automated reading	0.3	1.0	2.8	0.7	0.8	0.6	0.9	-1.3	-0.3	-1.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.0	3.8	0.1	-1.9	0.1	-0.0	0.4	0.7	1.7
Angina	0.1	0.2	0.3	-0.6	-0.2	-0.4	-0.3	-0.5	-0.4	-0.5
Medication for hormone replacement therapy	4.5	5.1	7.3	2.4	1.1	2.1	2.7	-2.0	2.7	-2.3
Vitamin and mineral supplements	0.5	0.6	2.1	-0.3	-1.5	-0.4	-0.0	0.9	0.2	1.0
Supplements: Zinc	2.0	2.2	4.5	1.2	2.1	1.5	1.0	-1.8	0.8	-1.4
Medication: Co-codamol	1.4	1.6	2.9	1.4	0.5	1.7	1.2	-0.4	1.7	-1.4
Medication: Metformin	0.8	1.1	2.3	1.0	0.6	1.0	1.1	-1.2	1.5	-0.4
Diabetes (father)	1.2	1.5	2.7	1.1	1.6	1.3	1.3	-0.9	0.6	-1.5
Diabetes (mother)	0.5	0.7	1.5	-0.4	-0.9	-0.3	-0.7	0.9	-1.0	1.2
Severe depression (siblings)	0.4	0.4	1.8	-0.1	1.4	0.1	-0.4	-0.5	-0.8	-0.4
Pack years adult smoking proportion	2.7	4.1	5.8	-2.1	-1.5	-2.1	-2.1	2.1	-1.8	2.4
Impedance of leg (right)	1.7	8.2	9.9	3.1	2.8	3.0	3.1	-2.9	2.5	-2.7
Leg fat-free mass (left)	0.2	1.0	2.5	1.0	0.4	1.2	0.6	-0.9	1.6	-0.7
Trunk fat percentage	1.9	7.7	11.2	3.2	1.6	3.2	3.3	-2.2	3.3	-2.1
Hand grip strength (right)	0.2	0.6	1.1	-0.6	-0.4	-0.6	-1.0	0.6	-0.9	1.0
Townsend deprivation index at recruitment	0.4	0.5	1.0	0.8	0.9	0.9	0.3	-1.0	0.2	-0.4
Current tobacco smoking	0.4	0.6	1.4	1.1	0.3	1.2	0.3	-0.7	0.2	0.9
Average weekly fortified wine intake	0.5	0.6	1.4	0.2	-1.1	0.3	0.7	0.7	1.2	0.1
Maternal smoking around birth	2.4	3.5	4.6	-2.0	-1.9	-1.9	-1.7	2.1	-1.2	2.0
Fed-up feelings	1.5	2.8	3.6	-1.7	-1.8	-1.4	-1.8	1.6	-1.4	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.2	-0.9	-1.4	-0.7	-1.3	1.0	-1.0	1.5
Relative age voice broke	0.2	0.3	1.0	0.3	-0.5	0.4	-0.0	-0.2	1.0	-0.6
Taking other prescription medications	0.4	0.6	2.1	0.7	0.2	0.6	0.7	-0.6	1.4	-0.7
Age when periods started (menarche)	1.5	3.5	5.7	2.4	0.8	2.2	2.3	-1.2	2.3	-1.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.5	-0.3	-0.7	-0.4	0.4	0.4	0.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.1	0.2	-0.1	-0.1	0.2	0.4	0.3
Tinnitus: Yes, but not now, but have in the past	6.1	6.5	10.8	2.6	0.8	2.7	2.7	-2.5	3.3	-2.5
Qualifications: CSEs or equivalent	0.5	0.6	1.7	-1.0	0.4	-1.0	-0.6	0.0	-1.3	0.4
Serious illness, injury or assault to yourself	0.9	1.1	3.2	-0.8	-1.8	-0.8	-0.4	1.3	0.3	1.1
High blood pressure	0.1	0.2	1.3	0.1	0.1	-0.1	0.2	0.2	-1.1	-0.2
Hayfever, allergic rhinitis or eczema	2.2	4.7	7.6	-2.8	-0.5	-2.6	-2.4	1.6	-2.8	1.3
Multivitamins +/- minerals	0.9	1.2	5.7	0.3	2.4	0.3	0.1	-1.3	-0.4	-0.7
Stomach or abdominal pain in last month	0.3	0.3	1.0	0.4	0.7	0.5	0.6	-1.0	-0.4	0.1
Supplements: Glucosamine	0.9	1.2	2.5	0.8	1.0	1.1	0.6	-1.3	1.0	-1.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	0.3	-0.6	0.2	-0.1	0.3	0.3	0.6
Medication: Atenolol	0.5	0.6	2.0	0.7	0.2	0.5	1.4	-0.0	1.1	-0.6
Medication: Levothyroxine sodium	0.2	0.3	0.7	0.0	0.4	-0.2	0.6	-0.5	0.8	-0.8
Sitting height	0.1	0.6	1.1	0.2	1.0	0.5	-0.4	-1.0	0.7	-0.9
Chronic bronchitis/emphysema (father)	2.9	3.4	4.3	-1.8	-1.8	-1.6	-1.8	2.1	-1.8	2.1
High blood pressure (mother)	0.5	0.7	1.4	-0.9	-0.6	-0.9	-0.6	0.8	-1.2	0.5
Body mass index (BMI)	0.6	2.4	3.6	1.9	0.9	1.9	1.6	-1.3	1.9	-1.1
Impedance of leg (left)	2.5	11.9	13.9	3.7	3.3	3.6	3.7	-3.5	3.0	-3.3
Leg predicted mass (left)	0.2	0.8	2.3	0.9	0.4	1.1	0.5	-0.8	1.5	-0.7
Trunk fat mass	1.8	7.8	10.4	3.1	1.9	3.2	3.1	-2.4	3.2	-2.2
Waist circumference	1.2	4.5	6.0	2.3	1.9	2.4	2.1	-2.0	2.1	-1.8
Number of incorrect matches in round	3.0	5.0	6.4	-2.4	-2.4	-2.3	-2.4	2.5	-1.4	2.0
Past tobacco smoking	2.3	4.3	11.7	-1.5	-3.4	-1.8	-1.0	2.1	-0.7	2.6
Alcohol usually taken with meals	1.5	2.4	4.5	1.3	2.1	1.4	0.9	-2.1	0.2	-1.7
Nervous feelings	3.3	6.2	10.9	-2.1	-3.2	-2.0	-1.6	3.0	-1.3	3.3
Frequency of tenseness / restlessness in last 2 weeks	2.9	4.6	6.8	-2.0	-2.1	-1.8	-1.7	2.6	-2.4	2.2
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.1	0.4	0.3	-0.5	-0.6	-0.6	-0.7
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.4	-0.1	-0.5	-0.3	-0.0	0.7	-0.0
Had menopause	0.2	0.2	1.3	-0.1	0.5	-0.2	-0.1	0.0	0.4	-1.1
Had other major operations	0.4	0.5	0.9	-0.9	-0.7	-0.8	-0.5	0.9	-0.4	0.6
Forced vital capacity (FVC)	0.1	0.5	0.9	0.7	0.0	0.9	0.7	-0.9	0.9	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	-0.8	-0.5	-0.7	-1.0	1.0	-0.2	1.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.3	-0.4	0.1	-0.1	-1.1	0.1	-0.5	0.1
Qualifications: None of the above	0.2	0.4	0.9	0.7	0.8	0.7	0.3	-1.0	0.5	-0.1
Financial difficulties in last 2 years	0.3	0.5	1.5	-0.3	1.1	-0.2	-0.5	-0.4	-1.2	0.2
Mouth/teeth dental problems	0.1	0.1	0.3	0.2	-0.5	0.2	-0.3	0.0	0.3	-0.2
Heart attack	0.4	0.5	1.3	0.2	0.5	0.3	0.1	-1.0	0.8	-1.1
Allergy	2.8	6.5	9.0	3.0	1.8	2.9	3.0	-2.5	2.3	-2.3
Pain all over the body in last month	0.0	0.0	0.1	-0.0	0.4	0.1	0.2	0.1	-0.0	0.1
Diabetes (self-reported)	0.2	0.3	1.3	0.0	-0.3	0.2	0.6	-0.2	1.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.6	-0.4	-0.5	-0.6	0.4	-0.4	0.1
Medication: Ramipril	1.2	1.5	4.4	-1.2	-0.1	-0.9	-1.5	1.1	-2.1	0.8
Medication: Simvastatin	0.1	0.2	0.4	-0.3	-0.6	-0.1	-0.2	0.4	0.6	-0.2
Fluid intelligence score	0.4	0.8	1.5	-1.2	-0.9	-1.0	-0.8	1.1	-0.3	-0.3
Illnesses of siblings	1.9	2.6	4.5	1.8	1.3	1.8	1.1	-2.1	2.0	-1.0
Neuroticism score	2.0	4.2	5.9	-2.2	-2.4	-1.8	-1.6	2.4	-1.3	2.4
Weight	1.4	6.8	9.1	2.8	2.0	3.0	2.5	-2.5	3.0	-2.2
Impedance of arm (right)	0.0	0.2	0.5	0.1	-0.6	0.0	0.7	0.5	0.3	0.2
Arm fat percentage (right)	0.7	2.9	4.5	2.1	1.1	2.0	2.1	-1.4	1.6	-1.3
Trunk fat-free mass	0.4	2.0	2.9	1.2	1.5	1.5	0.6	-1.6	1.7	-1.6
Hip circumference	0.8	3.4	5.8	1.8	1.4	2.0	1.6	-1.8	2.4	-1.7
Time employed in main current job	3.1	3.6	6.4	2.5	0.9	2.3	1.7	-2.0	2.0	-1.4
Alcohol intake versus 10 years previously	0.6	0.9	1.9	-1.2	-0.4	-1.0	-0.9	0.7	-1.4	0.4
Father’s age at death	0.8	1.1	2.3	-1.4	0.5	-1.5	-1.1	0.9	-1.0	-0.5
Worrier / anxious feelings	1.8	3.4	6.3	-2.0	-2.1	-1.8	-1.2	2.5	-1.4	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.7	0.1	-0.8	0.3	-0.2	0.4	-0.0	0.8
Falls in the last year	0.4	0.6	1.6	0.4	0.2	0.5	0.8	0.4	1.3	-1.0
Hair/balding pattern: Pattern 3	1.1	1.6	5.3	-0.9	0.9	-1.1	-1.3	0.2	-2.3	1.0
Number of live births	0.1	0.2	0.3	-0.4	0.6	-0.4	-0.5	0.3	0.5	-0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	0.4	-0.4	0.5	0.1	-0.6	0.2	0.3
Pulse rate	2.7	4.5	9.2	-1.8	-1.9	-1.8	-2.1	1.8	-2.2	3.0
Happiness	1.0	1.2	1.8	-1.2	-1.3	-1.2	-1.2	1.1	-1.0	0.2
Noisy workplace	0.2	0.2	1.0	-0.4	-0.1	0.0	-0.4	0.4	-1.0	0.5
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.5	-1.2	-1.1	-1.1	-0.7	1.2	-0.9	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.3	0.9	-0.9	1.0	0.8	-0.2	1.1	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.7	1.6	0.6	1.2	0.6	0.6	-1.3	0.4	-0.7
Asthma	1.0	1.9	3.7	-1.2	-1.7	-1.1	-1.3	1.9	-0.4	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	0.6	0.3	0.9	0.5	-0.8	-0.0	-0.3
Medication: Cholesterol lowering	2.0	3.1	4.9	-2.2	-0.8	-2.2	-1.9	1.7	-2.0	0.5
Depression (self-reported)	0.1	0.1	0.1	-0.4	-0.2	-0.3	-0.3	0.2	0.3	0.3
Medication: Lansoprazole	0.2	0.3	1.0	0.0	0.0	0.1	0.2	-0.7	0.6	-1.0
Prospective memory result	1.8	2.3	6.7	-1.9	-0.2	-1.7	-2.6	0.2	-1.6	0.6
Lung cancer (father)	2.2	2.5	4.0	-2.0	-0.6	-2.0	-1.5	1.5	-1.9	1.2
Illnesses of mother	0.2	0.2	0.7	-0.3	0.2	-0.4	-0.6	-0.1	-0.3	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	0.4	-0.1	0.4	-0.0	-0.5	-0.0	0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	0.3	-0.2	0.2	0.5	0.3	0.9	-0.5
Impedance of arm (left)	0.0	0.2	0.4	0.1	-0.6	0.1	0.6	0.5	0.2	0.5
Arm fat mass (right)	1.1	4.7	6.9	2.5	1.4	2.6	2.3	-1.9	2.4	-1.6
Trunk predicted mass	0.4	2.2	3.0	1.3	1.6	1.6	0.6	-1.6	1.7	-1.6
Standing height	0.7	7.3	8.6	2.5	2.7	2.7	2.1	-2.9	2.9	-2.9
Length of working week for main job	0.9	1.0	1.9	1.0	0.7	0.9	0.9	-1.4	1.1	-0.7
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.5	0.6	0.3	-0.3	-0.4	0.8	-0.1
Breastfed as a baby	0.2	0.3	0.6	-0.4	-0.7	-0.3	-0.6	0.6	0.0	0.6
Tense / ‘highly strung’	0.3	0.4	1.4	-0.2	-1.2	-0.1	0.4	0.6	0.2	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.1	-0.3	0.3	-0.3	0.5	0.3	0.3
Hair/balding pattern: Pattern 4	1.8	4.4	8.5	-1.9	-2.9	-1.7	-1.8	2.4	-1.1	2.2
Birth weight of first child	0.3	0.5	1.8	-0.6	0.1	-0.6	-1.0	0.4	-1.3	0.1
Peak expiratory flow (PEF)	0.2	0.6	1.5	-0.7	-0.4	-0.7	-1.0	0.1	-1.2	0.7
Pulse wave reflection index	0.4	0.5	1.0	0.6	-0.4	0.4	1.0	-0.1	1.0	-0.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	0.7	-0.3	1.0	0.4	-0.9	0.4	0.7
Loud music exposure frequency	0.1	0.1	0.1	-0.2	0.4	-0.2	-0.2	0.1	-0.3	0.3
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.2	1.6	0.9	1.7	1.8	-1.6	1.3	-1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.0	-0.8	-0.3	-0.7	-0.5	-0.0	-1.0	1.4
Blood clot in the leg (DVT)	3.9	5.0	8.5	-2.2	-2.4	-2.1	-2.3	2.2	-1.2	2.9
Medication: Paracetamol	0.4	0.7	1.5	0.7	0.1	0.8	0.9	-1.0	1.2	-0.4
Headache pain in last month	0.3	0.5	1.4	-0.2	-1.2	-0.0	0.1	0.7	-0.3	1.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.1	1.0	-0.4	1.0	0.8	-0.4	1.4	0.6
Glaucoma (self-reported)	1.2	1.5	2.3	1.3	1.2	1.3	1.5	-0.5	1.5	-0.6
Gout (self-reported)	0.2	0.2	1.0	-0.4	-0.6	-0.3	0.3	1.0	-0.0	-0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.2	-1.0	-0.3	-1.1	-0.6	0.9	-0.3	0.5
Medication: Amlodipine	0.1	0.1	0.2	-0.2	-0.4	-0.3	-0.2	-0.3	-0.1	0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.6	-0.5	-1.2	-0.6	-0.4	1.3	-0.3	0.5
Birth weight	0.0	0.1	0.3	0.1	-0.3	0.4	-0.2	-0.1	-0.6	0.3
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	-0.2	-0.4	-0.4	0.5	0.6	0.9	0.5
High blood pressure (siblings)	0.4	0.6	2.5	-0.5	0.4	-0.7	-0.0	1.0	-1.6	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	1.3	0.8	0.5	0.9	0.6	-1.2	0.8	-0.8
Body fat percentage	2.4	9.3	12.6	3.5	2.0	3.5	3.5	-2.6	3.4	-2.4
Leg fat percentage (right)	2.5	9.2	12.5	3.5	2.4	3.5	3.4	-2.9	3.2	-2.2
Arm fat-free mass (right)	1.1	5.7	6.9	2.3	2.4	2.5	1.6	-2.6	2.6	-2.4
Exposure to tobacco smoke outside home	0.6	0.8	2.0	-0.9	-0.9	-1.0	-0.5	1.4	-0.3	0.9
Comparative body size at age 10	0.1	0.3	1.4	0.3	-0.5	0.3	0.4	0.2	1.2	-0.3
Number of full brothers	0.8	1.0	4.3	-0.6	1.0	-0.6	-0.9	0.2	-2.1	0.0
Worry too long after embarrassment	7.5	12.6	16.5	-4.1	-2.7	-3.8	-3.4	3.9	-3.4	3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.4	1.2	0.2	1.4	1.1	-0.6	1.8	-0.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.8	0.1	-1.3	0.4	-0.3	0.5	1.0	0.4
Number of children fathered	1.8	2.0	2.5	1.5	1.3	1.4	1.5	-1.3	1.6	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.7	0.7	1.3	0.7	0.7	-0.7	0.8	-1.3
Age at first live birth	0.2	0.3	1.0	-0.3	-0.1	-0.2	0.3	-0.5	0.7	-1.0
Pulse wave peak to peak time	0.2	0.2	0.6	-0.4	0.3	-0.2	-0.6	-0.3	-0.8	0.4
Health satisfaction	0.7	0.9	2.1	0.8	0.3	0.9	0.9	-0.5	1.4	-1.2
Shortness of breath walking on level ground	0.3	0.4	0.9	0.7	-0.0	0.7	0.5	-0.8	0.9	-0.2
Qualifications: College or University degree	0.2	0.7	1.8	-0.6	-1.3	-0.5	-0.0	1.3	0.8	-0.4
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.1	0.3	0.0	-0.6	-0.4	-0.5	-0.8
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.2	0.3	-0.1	-0.5	-0.2	-0.5	0.3
Emphysema/chronic bronchitis	1.7	1.9	4.5	1.2	0.4	1.4	0.9	-1.3	2.1	-1.6
Medication for pain relief, constipation, heartburn	0.8	1.4	1.7	-1.2	-1.1	-1.2	-1.3	1.3	-0.8	1.3
Neck or shoulder pain in last month	1.4	1.9	3.8	1.6	0.4	1.9	1.3	-1.5	1.5	-0.8
Medication: Blood pressure	0.6	1.0	2.5	-1.2	-0.5	-1.0	-1.0	1.0	-1.6	0.3
Angina (self-reported)	0.2	0.2	0.5	-0.4	-0.0	-0.2	-0.3	-0.7	-0.4	-0.7
Migraine (self-reported)	2.8	3.4	5.3	1.7	2.0	1.6	1.8	-2.3	1.0	-2.3
Medication: Ibuprofen	0.6	0.7	1.5	0.9	0.7	1.2	0.8	-1.2	0.2	-0.3
Medication: Allopurinol	0.0	0.1	0.2	-0.2	-0.1	-0.2	-0.0	0.4	0.1	-0.3
Medication: Omeprazole	0.7	0.9	2.9	0.8	0.7	0.8	1.0	-1.7	0.5	-0.3
Medication: Seretide 50 evohaler	1.1	1.3	3.2	-0.8	-1.8	-0.6	-0.8	1.8	0.2	1.1
Mean time to correctly identify matches	1.4	2.7	3.5	-1.8	-1.8	-1.8	-1.8	1.5	-0.7	1.9
Heart disease (mother)	0.5	0.6	1.7	-0.9	-0.3	-1.0	-0.6	0.4	-1.3	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.1	6.1	7.9	-2.6	-1.7	-2.8	-2.7	2.1	-2.7	2.5
Whole body fat mass	2.3	9.4	12.4	3.4	2.2	3.5	3.3	-2.8	3.5	-2.5
Leg fat mass (right)	2.2	8.5	11.4	3.4	2.2	3.4	3.0	-2.8	3.2	-2.2
Arm predicted mass (right)	1.0	5.1	6.4	2.2	2.2	2.5	1.5	-2.5	2.5	-2.2
Pulse rate, automated reading	1.6	5.3	8.1	-2.2	-2.9	-2.1	-2.2	2.5	-1.3	2.7
Alcohol intake frequency.	0.4	1.0	3.1	0.9	0.6	0.9	1.1	-1.8	0.9	0.4
Comparative height size at age 10	0.6	3.2	6.8	1.2	2.6	1.5	1.2	-1.8	1.8	-2.0
Number of full sisters	0.7	0.9	4.1	0.3	2.0	0.4	0.3	-0.9	-0.7	-0.9
Suffer from ‘nerves’	0.8	1.2	1.7	-1.3	-0.7	-1.2	-1.1	1.1	-1.2	1.1
Overall health rating	0.1	0.1	0.4	-0.6	0.4	-0.4	-0.2	-0.0	-0.2	-0.3
Chest pain or discomfort	0.3	0.4	0.9	-0.3	-0.9	-0.2	0.5	0.9	0.8	0.6
Had major operations	0.1	0.1	0.5	-0.1	-0.1	0.2	0.2	0.0	0.7	-0.5
Age at last live birth	0.2	0.2	0.5	-0.7	-0.6	-0.7	-0.3	0.6	-0.1	0.0
Family relationship satisfaction	0.0	0.1	0.2	0.1	-0.2	0.3	-0.0	-0.2	0.4	-0.0
Leg pain on walking	0.1	0.2	0.3	0.5	0.4	0.6	0.4	-0.5	0.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.1	0.0	-0.1	0.2	0.2	0.7	-0.8	1.0
Commuting to job workplace: Car/motor vehicle	2.1	2.4	5.5	1.2	2.4	1.4	1.0	-2.1	0.5	-1.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	0.4	1.2	0.4	0.3	-0.8	0.1	-0.5
Medication: Aspirin	0.4	0.6	1.5	0.6	1.1	0.5	0.2	-0.8	-0.4	-1.2
Supplements: Vitamin C	2.7	3.2	6.2	1.5	1.6	1.8	1.2	-2.5	1.5	-2.1
Knee pain experienced in last month	0.2	0.3	1.3	0.4	-0.4	0.4	0.1	0.4	0.3	1.1
Hypertension (Self-reported)	0.2	0.4	2.2	-0.2	-0.2	-0.4	-0.2	0.5	-1.5	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	4.0	1.8	1.6	2.0	1.6	-1.9	1.3	-1.9
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.3	0.1	-0.1	-0.4	0.1	-0.7	-0.2
Illnesses of siblings: Diabetes	0.3	0.3	0.5	-0.7	-0.7	-0.5	-0.6	0.6	-0.4	0.4
Smoking status: Previous	2.6	3.9	9.7	1.5	3.1	1.5	1.1	-1.9	1.0	-2.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.3	0.7	1.2	0.9	0.5	-0.9	1.1	-1.5
Whole body fat-free mass	0.4	2.2	3.8	1.4	1.3	1.6	0.8	-1.5	1.9	-1.5
Leg fat-free mass (right)	0.2	0.9	2.6	0.9	0.3	1.0	0.6	-0.8	1.6	-0.8
Arm fat percentage (left)	0.8	3.1	4.7	2.2	1.0	2.1	2.1	-1.4	1.8	-1.2
Average weekly red wine intake	1.7	2.5	5.1	1.9	0.0	2.2	1.4	-1.3	2.1	-1.0
Handedness (chirality/laterality): Left-handed	4.3	5.2	9.2	-2.6	-1.1	-2.5	-2.7	1.7	-3.0	1.6
Mood swings	0.1	0.2	0.6	0.1	-0.8	0.2	0.3	0.6	-0.3	0.4
Loneliness, isolation	3.3	4.6	5.6	-2.4	-1.4	-2.4	-2.3	2.1	-2.4	2.0
Long-standing illness, disability or infirmity	4.2	6.5	12.8	2.4	1.0	2.5	3.1	-2.4	3.6	-2.1
Ever had bowel cancer screening	6.6	7.8	15.4	2.4	3.4	2.5	2.2	-2.8	1.6	-3.9
Diabetes diagnosed by doctor	0.5	0.8	1.6	0.7	0.5	0.8	1.0	-1.0	1.3	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.7	-0.9	-1.3	-0.9	-0.9	1.1	-0.5	1.6
Friendships satisfaction	0.2	0.2	0.4	-0.7	-0.5	-0.6	-0.1	0.4	-0.6	-0.0
Qualifications: nursing, teaching	0.2	0.3	1.0	0.4	0.4	0.4	0.6	-0.2	0.2	-1.0
Commuting to job workplace: Walk	1.5	1.7	6.2	-0.2	-2.5	-0.3	0.1	1.6	0.7	1.4
Eye problems/disorders: Cataract	0.8	0.9	1.8	1.2	0.5	1.0	1.3	-1.1	0.9	0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.0	0.8	0.1	1.2	1.0	-0.1	1.4	-1.0
Medication for cholesterol	8.8	13.3	17.6	-3.6	-3.4	-3.6	-3.8	3.7	-3.2	4.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	4.2	1.5	2.0	1.4	1.5	-1.4	0.5	-1.9
Back pain experienced in last month	0.7	1.0	2.4	1.1	0.2	1.0	1.5	-1.0	1.0	-0.3
Mineral and other dietary supplements	1.2	1.6	4.7	-0.5	-1.6	-0.6	-0.7	1.5	-0.7	2.2
Breast cancer (self-reported)	0.6	0.7	1.5	-0.9	-1.0	-0.9	-1.2	0.5	-0.5	0.5
Asthma (self-reported)	0.9	1.9	3.3	-1.4	-1.4	-1.3	-1.4	1.8	-0.7	1.2
Osteoporosis (self-reported)	0.7	0.8	1.4	1.1	0.2	1.2	0.9	-1.1	0.9	-0.5
Osteoarthritis (self-reported)	0.5	0.7	2.4	-0.5	1.6	-0.5	-0.5	0.6	-1.0	-0.7
Medication: Aspirin	0.2	0.2	0.6	-0.0	0.4	-0.1	-0.3	-0.2	-0.8	-0.8
Medication: Gliclazide	0.7	0.8	1.3	-1.2	-1.0	-0.9	-1.1	0.8	-0.5	0.5
Illnesses of father: None of the above (group 1)	1.6	2.0	4.2	1.2	1.3	1.1	1.4	-2.1	1.0	-1.5
Smoking status: Current	0.3	0.6	1.4	1.0	0.4	1.2	0.2	-0.6	0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.6	1.1	0.6	1.1	1.3	-1.1	0.5	-0.9
Whole body water mass	0.4	2.3	3.6	1.4	1.4	1.6	0.8	-1.6	1.9	-1.6
Leg predicted mass (right)	0.2	1.0	2.9	1.0	0.3	1.1	0.7	-0.9	1.7	-0.8
Arm fat mass (left)	1.1	4.6	6.5	2.5	1.5	2.5	2.2	-1.9	2.5	-1.6
Number of self-reported non-cancer illnesses	0.3	0.5	1.4	0.7	1.2	0.9	0.4	-0.8	0.2	-0.5
Average weekly champagne plus white wine intake	0.8	1.1	4.1	1.0	2.0	0.8	0.6	-0.7	-0.0	-1.1
Miserableness	1.2	2.0	5.8	-1.1	-1.9	-0.6	-1.3	0.9	-0.9	2.4
Guilty feelings	2.6	3.9	6.1	-2.5	-1.9	-2.0	-2.4	1.8	-1.4	1.7
Wears glasses or contact lenses	0.1	0.1	0.3	-0.0	0.1	-0.0	-0.2	-0.0	0.5	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.5	-0.1	0.1	-0.1	-0.3	0.4	-0.7	-0.2
Hearing aid user	2.9	3.3	6.4	1.5	1.8	1.3	1.9	-2.5	1.6	-1.8
Mother’s age at death	0.3	0.4	1.5	-0.5	-0.5	-0.4	-0.5	1.2	-0.5	-0.1
Financial situation satisfaction	0.3	0.3	1.2	-0.4	-0.0	-0.3	-0.6	0.2	-1.1	0.6
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.4	-0.6	0.5	-0.4	-0.3	-0.2	-0.4	-0.3
Commuting to job workplace: Public transport	0.6	0.7	1.7	-0.6	-1.3	-0.5	-0.8	1.0	-0.7	0.7
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.2	0.1	-0.2	0.2	0.6	0.2	0.3
Medication: Blood pressure	1.3	2.4	3.2	1.6	1.5	1.6	1.5	-1.6	1.3	-1.8
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.3	1.4	2.1	1.3	0.9	-1.8	0.2	-1.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.6	0.3	1.3	0.4	0.5	-0.8	0.2	-1.9
High cholesterol (Self-reported)	0.3	0.5	2.0	-0.5	1.4	-0.3	-0.1	0.2	-0.7	-0.8
Medication: Bendroflumethiazide	0.3	0.4	1.3	-0.5	0.2	-0.5	-0.5	0.3	-1.1	0.7
Medication: Paracetamol	0.2	0.3	0.6	0.2	0.7	0.3	0.3	-0.8	0.6	-0.4
Medication: Lisinopril	0.2	0.3	0.7	-0.7	-0.0	-0.8	-0.6	0.1	0.1	-0.8
Medication: Atorvastatin	1.0	1.3	2.8	-1.3	0.4	-1.3	-1.4	0.7	-1.7	-0.5
Illnesses of father: High blood pressure	2.1	2.6	3.9	-1.3	-1.8	-1.3	-1.9	2.0	-1.2	1.6
Alcohol drinker status: Never	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.1	0.0	-0.3	0.2
Ever smoked	0.9	1.7	5.6	0.7	2.4	1.0	0.2	-1.3	-0.3	-1.7
Basal metabolic rate	0.6	3.2	5.3	1.8	1.5	2.0	1.3	-1.8	2.3	-1.7
Leg fat percentage (left)	3.1	11.2	14.6	3.8	2.7	3.8	3.6	-3.3	3.4	-2.5
Arm fat-free mass (left)	1.3	6.6	8.3	2.5	2.4	2.7	1.9	-2.8	2.9	-2.6
Number of operations (self-reported)	0.1	0.2	0.7	-0.5	-0.0	-0.3	-0.2	0.8	0.3	-0.5
Average weekly beer plus cider intake	1.1	1.6	2.9	-1.3	-0.3	-1.3	-1.7	1.4	-1.7	0.1
Irritability	0.1	0.2	0.5	0.5	0.4	0.6	0.1	-0.1	-0.7	0.3
Risk taking	2.7	4.0	7.2	2.6	1.5	2.7	1.9	-1.6	1.8	-1.6
Ever had prostate specific antigen (PSA) test	3.2	3.7	6.7	1.9	2.6	1.6	1.7	-1.9	1.1	-2.3
Fractured/broken bones in last 5 years	0.1	0.1	0.7	-0.1	0.1	-0.0	0.0	0.8	-0.5	-0.3
Age started oral contraceptive pill	0.6	0.7	1.6	-1.3	0.1	-1.1	-1.1	0.4	-0.7	-0.6
Diastolic blood pressure, automated reading	0.1	0.3	0.9	0.5	-0.3	0.4	0.6	-0.9	-0.1	-0.4
Ever depressed for a whole week	1.7	2.1	3.3	1.4	1.8	1.7	1.1	-1.7	0.8	-1.3
Unable to work because of sickness or disability	1.6	2.1	4.5	0.9	1.7	0.9	1.3	-1.5	1.1	-2.1
Commuting to job workplace: Cycle	1.4	1.6	3.3	1.5	-0.3	1.5	1.7	-0.4	1.8	-0.7
Myopia	0.1	0.2	0.3	-0.1	-0.2	-0.2	-0.5	0.5	-0.5	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.6	-0.5	-0.4	-0.7	0.5	0.4	0.8
Cholesterol lowering medication	2.3	3.4	4.5	1.7	1.7	1.8	1.9	-1.6	1.9	-2.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	3.2	0.9	1.0	1.0	0.9	-1.8	0.4	-0.5
Pain experienced in last month	0.2	0.3	0.6	-0.6	-0.0	-0.8	-0.7	0.2	-0.4	-0.6
Supplements: Calcium	0.4	0.4	1.3	0.5	0.4	0.8	0.2	-1.1	0.7	0.0
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	-0.7	0.3	-0.8	-0.5	0.5	-0.3	0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	-0.0	0.1	0.1	-0.0	-0.7	0.7	-0.9
Deep venous thrombosis (DVT) (self-reported)	2.8	3.5	5.8	-1.9	-1.9	-1.8	-2.0	1.9	-1.1	2.4
Heart disease (siblings)	1.3	1.5	2.9	-1.3	-0.8	-1.4	-1.0	1.3	-1.7	1.0
Alcohol drinker status: Previous	0.1	0.1	0.7	0.2	-0.2	0.2	0.2	-0.8	0.1	0.3
Pack years of smoking	2.4	3.6	4.4	-2.1	-1.1	-2.1	-2.0	1.8	-1.8	2.1
Impedance of whole body	0.5	2.4	4.3	1.7	1.2	1.6	2.1	-1.3	1.4	-1.2
Leg fat mass (left)	2.4	9.4	12.4	3.5	2.4	3.5	3.1	-3.0	3.3	-2.4
Arm predicted mass (left)	1.0	5.3	6.9	2.2	2.1	2.5	1.6	-2.5	2.6	-2.3