Hub : Genes

FAN1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0900 0.0230 4.0e-10 0.123 0.081 0.111 0.100 0.118 1.1e-14 4.3e-10 1.9e-13 3.7e-12 3.9e-14
2 GTEx Adipose Subcutaneous 0.0950 0.0330 4.2e-05 0.044 NA 0.064 NA 0.080 1.7e-04 NA 5.9e-06 NA 4.4e-07
3 GTEx Brain Cerebellum 0.2810 0.0860 1.9e-04 0.300 NA 0.254 NA 0.272 1.6e-09 NA 4.0e-08 NA 1.1e-08
4 GTEx Lung 0.0446 0.0213 9.0e-03 0.027 NA 0.051 NA 0.047 3.5e-03 NA 9.1e-05 NA 1.5e-04
5 GTEx Spleen 0.3500 0.1340 7.0e-04 0.144 NA 0.117 NA 0.141 1.6e-04 NA 6.5e-04 NA 1.8e-04
6 GTEx Whole Blood 0.1520 0.0430 1.4e-08 0.117 NA 0.117 NA 0.084 6.9e-11 NA 6.6e-11 NA 3.8e-08
7 NTR Blood 0.0197 0.0067 7.7e-06 0.008 0.012 0.016 0.014 0.016 1.1e-03 5.5e-05 5.8e-06 1.8e-05 3.8e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.1 0.2 0.6 -0.2 0.4 -0.7 0.8 0.1 0.0 0.5
Bipolar Disorder or Schizophrenia 0.4 1.0 2.0 0.6 1.4 -1.4 1.1 -0.0 0.4 1.3
Depressed Affect (Nagel 2018) 0.4 0.9 3.7 -1.1 -0.8 0.5 0.2 1.9 0.0 0.5
Depression (Nagel 2018) 0.9 1.4 5.0 -0.6 -0.8 1.4 0.3 2.2 0.6 1.0
Intelligence (Savage-Jansen 2018) 2.1 6.5 12.9 -3.1 -3.0 2.0 -2.7 -0.4 -1.7 -3.6
Neuroticism (Nagel 2018) 0.6 1.3 3.1 -1.8 -1.6 1.1 -0.6 1.1 -0.8 -0.4
Schizophrenia (2018) 0.5 1.1 2.6 0.9 1.6 -1.2 0.8 -0.1 0.7 1.2
Schizophrenia vs Biploar Disorder 0.5 0.7 2.8 1.7 1.0 0.5 -0.5 -0.1 -0.8 -0.2
Worry (Nagel 2018) 1.2 2.5 3.5 -1.6 -1.8 1.2 -1.6 -1.3 -1.9 -1.5
Alzheimer’s Disease (in mother) 2.7 3.2 7.3 -0.8 0.8 -2.7 2.4 1.3 2.3 1.1
Alzheimer’s Disease (in father) 0.6 0.6 1.0 -1.0 -0.6 0.2 -0.9 0.6 -0.9 -1.0
Alzheimer’s Disease (including proxy) 1.0 1.5 3.1 -1.6 -0.4 -1.8 0.9 1.7 1.0 0.0
Crohns Disease (2017) 0.1 0.3 0.7 -0.5 0.1 -0.8 0.9 0.6 -0.3 -0.0
Irritable Bowel Disease (IBD) 0.0 0.1 0.3 0.0 0.2 -0.4 0.6 -0.1 -0.2 0.5
Ulcerative Colitis (UC) 0.2 0.5 1.7 0.5 0.6 -0.3 0.6 -0.1 0.6 1.3
Major Depression (MDD) 2.3 2.7 5.9 -0.9 -1.8 2.4 -1.5 -1.7 -1.0 -1.8
Reaction Time 0.5 1.0 1.7 -1.3 -1.3 0.6 -0.8 0.6 -0.9 -1.3
Verbal and Numeric Reasoning (VNR) 0.9 2.2 6.0 -2.4 -1.9 0.8 -1.1 0.8 0.3 -1.8
Breast Cancer 0.6 1.4 3.4 0.2 1.1 -1.6 1.1 1.8 1.0 0.8
Ovarian Cancer 0.5 0.7 1.7 1.0 1.3 -0.8 0.7 -0.1 0.9 0.5
Prostate Cancer 1.5 2.1 4.7 0.7 1.0 -0.9 1.8 1.9 1.1 2.2
Age at First Birth 0.5 0.8 2.3 0.3 1.2 -0.7 0.6 0.1 0.9 1.5
Bipolar Disorder (2011) 0.7 0.7 1.4 1.0 0.9 -0.4 0.9 -0.1 0.8 1.2
Body Mass Index (BMI) (2010) 0.2 0.3 0.8 0.5 0.4 0.5 -0.3 -0.8 -0.9 0.1
Coronary Artery Disease (CAD) 0.4 0.5 1.5 0.1 -0.0 -0.9 -0.3 1.2 -0.3 1.0
Crohns Disease (2012) 0.1 0.2 0.7 -0.8 -0.6 -0.2 0.3 0.1 -0.2 0.1
Mean Putamen Volume 0.8 1.0 2.6 -0.3 -0.1 -0.8 1.0 1.1 1.6 1.0
Fasting Glucose 1.1 1.4 3.6 -1.9 -1.9 0.9 -0.9 -0.3 -0.4 -0.7
HbA1C 0.2 0.3 1.0 0.4 1.0 0.7 0.1 0.5 0.1 0.1
HDL Cholesterol 0.5 0.8 2.2 0.4 -0.6 0.1 1.0 1.5 1.1 0.7
LDL Cholesterol 0.5 0.7 1.3 0.5 -0.6 1.1 -0.7 -0.8 -0.9 -1.1
Lupus 0.5 0.7 1.8 -0.5 -0.0 -0.5 -0.6 -1.3 -1.2 -0.9
Neuroticism (2016) 0.4 0.6 1.6 -1.1 -1.3 0.2 -0.5 1.2 0.1 -0.2
Primary Biliary Cirrhosis 0.4 0.5 1.3 -1.1 -0.6 -0.4 0.4 1.1 0.6 0.3
Rheumatoid Arthritis 0.4 0.5 1.0 -0.5 -0.8 0.8 -1.0 -0.1 -0.9 -0.6
Schizophrenia (2014) 0.3 0.6 1.3 0.5 1.2 -0.7 0.6 0.3 0.7 1.1
Triglycerides 0.5 0.7 1.4 -0.3 -0.4 0.9 -1.2 -0.4 -1.2 -1.1
Type 2 Diabetes (T2D) (2012) 0.5 0.5 2.7 -0.4 0.6 -0.4 -0.4 -1.6 0.1 0.3
Ulcerative Colitis 0.4 0.6 2.5 0.5 0.1 -0.1 0.0 -1.6 0.0 1.2
Blood Eosinophil Count 0.1 0.6 1.7 1.1 -0.2 0.8 -0.1 -1.3 -0.2 -0.6
Blood Platelet Count 0.1 1.2 3.8 -2.0 -1.0 0.2 -0.8 1.5 -0.1 -1.0
Blood Red Count 0.2 1.7 3.1 -1.5 -1.3 -0.4 -1.8 -0.3 -1.4 -1.6
Blood White Count 0.2 1.1 2.2 1.0 -0.2 1.5 -0.8 -1.2 -1.4 -0.8
Heel T-Score 0.3 2.2 5.0 -1.0 0.1 -2.0 1.6 2.2 1.6 0.8
BMI 0.9 5.1 10.2 3.1 3.2 -1.3 2.3 1.7 0.7 2.3
Height 0.2 3.1 10.4 -2.0 0.2 -2.1 0.4 3.2 0.9 1.2
Waist Hip Ratio (WHR) 0.2 1.0 2.4 -0.0 0.4 -1.5 0.9 0.5 1.5 0.9
Systolic Blood Pressure 0.4 1.9 3.8 0.5 1.0 -1.4 1.4 1.5 1.6 1.9
Smoking Status 1.1 2.6 5.5 -1.3 -2.4 1.5 -1.4 -1.5 -1.5 -1.6
Allergy or Eczema 0.4 1.1 2.5 -1.6 -1.2 0.6 -0.9 0.2 -0.7 -1.3
Cardiovascular Disease 0.7 2.4 6.3 2.5 1.5 0.3 1.6 0.7 0.8 2.1
Hypothyroidism (self reported) 0.4 0.9 2.3 -0.8 -1.0 0.1 -0.9 -0.1 -1.5 -1.1
Respiratory disease 0.3 0.6 3.0 -0.6 -0.6 -0.2 -0.1 1.7 0.5 0.4
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.9 1.2 1.1 -0.5 1.4 -0.3 0.8 1.1
Lung FEV1/FVC ratio 0.7 3.5 7.2 -0.6 0.3 -2.2 1.8 2.7 1.5 2.5
Lung FVC 0.1 0.6 1.1 -0.4 -0.4 0.3 -0.8 -1.0 -1.1 -0.9
Neuroticism 1.1 2.7 5.8 -1.8 -2.4 1.8 -1.5 -0.2 -1.7 -1.2
Chronotype (morning person) 0.4 1.0 2.8 1.7 0.5 0.7 -0.5 -0.8 -1.3 -0.6
Hair Pigment 0.1 3.9 11.0 0.3 -0.5 0.7 -2.3 -2.7 -3.3 -1.7
Tanning 0.3 3.7 12.3 -3.5 -1.8 -0.6 0.3 1.6 2.1 1.7
Hand grip strength (left) 0.2 0.6 1.2 0.4 0.0 0.7 -1.1 -1.1 -0.8 -0.9
Number of treatments/medications taken 0.6 1.0 5.5 -0.5 -0.5 0.6 0.6 2.3 0.4 0.4
Average weekly spirits intake 0.9 1.1 3.1 -0.6 -0.7 0.8 -1.4 -0.6 -1.8 -1.1
Sensitivity / hurt feelings 1.2 2.0 6.2 -2.2 -2.5 1.2 -0.3 0.8 -0.5 -1.0
Frequency of depressed mood in last 2 weeks 1.7 2.3 9.4 -0.7 -2.2 3.1 -1.2 0.3 -0.6 -0.3
Hearing difficulty/problems: Yes 0.6 0.9 2.2 -0.0 -0.6 1.5 -1.2 0.5 -1.3 -0.5
Relative age of first facial hair 0.4 0.9 2.2 -1.3 -1.5 0.7 -1.1 0.4 0.2 -0.4
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 4.7 -2.2 -1.5 -0.3 -0.2 1.3 -0.2 -0.5
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.2 0.6 -0.5 0.9 -0.1 -1.1 -0.5 0.0
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 0.8 0.1 0.2 0.6 -0.6 0.2 0.2
Systolic blood pressure, automated reading 1.4 4.0 5.4 0.7 2.1 -2.3 2.1 2.2 2.0 2.0
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 4.0 -0.5 -1.4 2.0 -1.2 0.3 -0.7 -0.5
Angina 2.8 3.7 8.1 -2.4 -2.9 1.7 -1.8 -0.2 -1.9 -1.5
Medication for hormone replacement therapy 0.3 0.3 1.2 -0.3 -0.2 0.1 -0.4 -0.7 -1.1 -0.5
Vitamin and mineral supplements 0.1 0.1 0.5 -0.2 -0.0 -0.1 -0.1 -0.1 0.7 0.5
Supplements: Zinc 0.6 0.6 1.6 0.8 -0.3 0.7 -0.4 -1.2 -1.1 0.0
Medication: Co-codamol 0.5 0.6 2.1 -0.1 -0.5 0.4 0.5 1.5 0.8 0.8
Medication: Metformin 0.2 0.3 0.8 0.7 0.9 -0.2 0.8 0.0 -0.0 0.2
Diabetes (father) 1.2 1.5 3.6 1.7 0.9 -0.6 1.2 0.4 1.2 1.9
Diabetes (mother) 0.1 0.1 0.3 0.2 0.0 0.0 0.4 -0.3 0.3 0.5
Severe depression (siblings) 0.3 0.3 1.6 0.0 -0.4 -0.2 0.3 0.3 0.6 1.3
Pack years adult smoking proportion 0.9 1.4 2.6 -1.6 -1.4 1.2 -0.9 1.5 -0.5 -0.5
Impedance of leg (right) 2.3 11.1 20.3 -4.2 -4.5 2.8 -3.7 -1.7 -1.8 -3.4
Leg fat-free mass (left) 1.2 6.5 8.7 2.4 2.9 -2.3 2.9 2.7 1.7 2.7
Trunk fat percentage 0.1 0.4 1.1 0.7 0.7 -0.3 0.2 1.1 -0.9 0.0
Hand grip strength (right) 0.1 0.4 1.0 0.0 -0.2 0.1 -0.6 -0.9 -0.6 -1.0
Townsend deprivation index at recruitment 0.6 0.8 3.5 -0.4 -0.4 -0.7 -0.4 -1.9 -0.3 -1.2
Current tobacco smoking 0.6 1.0 3.6 -0.6 -1.9 1.1 -0.8 -0.6 -0.7 -0.5
Average weekly fortified wine intake 0.3 0.3 1.1 -0.7 0.4 -1.0 -0.4 -0.5 -0.6 -0.1
Maternal smoking around birth 0.2 0.2 0.6 0.7 -0.4 0.3 0.2 0.4 -0.8 0.0
Fed-up feelings 0.3 0.6 1.5 -1.0 -1.2 0.9 -0.3 0.9 -0.2 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 4.0 -0.3 -1.2 2.0 -0.4 0.6 -0.5 -0.6
Relative age voice broke 0.9 1.4 3.5 -0.9 -1.9 1.4 -1.5 -0.2 -0.6 -0.8
Taking other prescription medications 1.0 1.6 5.5 -1.1 -1.1 -0.7 0.8 2.3 0.5 1.2
Age when periods started (menarche) 0.7 1.6 4.7 -1.8 -2.2 0.4 -1.1 -0.4 -0.4 -1.3
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 2.9 0.3 -1.4 1.7 -0.7 -1.1 -1.0 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.2 0.2 0.5 -0.3 0.7 0.3 0.7 1.1
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 2.8 -1.4 -1.7 0.7 -0.6 -0.8 -0.7 -1.0
Qualifications: CSEs or equivalent 3.2 4.3 7.3 -0.7 -2.2 2.2 -1.9 -2.7 -2.1 -2.0
Serious illness, injury or assault to yourself 0.3 0.3 1.1 -0.7 -0.7 0.0 0.1 1.0 -0.1 -0.4
High blood pressure 1.5 4.1 9.1 2.1 2.1 -0.4 2.4 1.5 1.6 3.0
Hayfever, allergic rhinitis or eczema 0.8 1.7 3.1 -1.8 -1.6 1.2 -1.4 -0.0 -1.1 -1.4
Multivitamins +/- minerals 0.1 0.1 0.5 0.3 0.4 0.1 0.1 0.7 -0.2 0.1
Stomach or abdominal pain in last month 2.0 2.5 3.1 -1.7 -1.6 1.7 -1.8 -0.1 -1.7 -1.7
Supplements: Glucosamine 0.7 1.0 2.3 0.6 0.9 -1.1 1.0 1.5 0.5 0.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.6 -0.6 -0.7 0.0 -0.8 -0.3 -1.0 -1.2
Medication: Atenolol 0.1 0.1 0.6 0.4 -0.3 0.8 0.2 -0.1 -0.1 0.2
Medication: Levothyroxine sodium 0.2 0.3 1.7 0.6 -0.0 0.1 -0.1 -0.0 -1.3 -0.3
Sitting height 0.1 0.4 1.7 0.2 0.3 0.5 -0.9 0.0 -1.3 -0.1
Chronic bronchitis/emphysema (father) 2.1 2.5 5.2 0.5 1.4 -1.2 1.7 1.6 2.3 1.6
High blood pressure (mother) 0.3 0.4 1.0 0.4 0.6 -0.5 0.6 -1.0 0.9 0.4
Body mass index (BMI) 1.5 6.3 14.2 3.8 3.5 -1.5 2.9 1.4 0.8 2.1
Impedance of leg (left) 2.4 11.4 18.5 -3.7 -4.3 2.9 -4.0 -2.2 -2.4 -3.6
Leg predicted mass (left) 1.2 6.4 8.8 2.5 3.0 -2.3 2.8 2.6 1.6 2.7
Trunk fat mass 0.3 1.5 2.8 1.6 1.7 -0.9 1.0 1.6 -0.4 0.7
Waist circumference 0.9 3.4 6.8 2.6 2.4 -1.5 2.0 1.7 0.3 1.3
Number of incorrect matches in round 0.5 0.8 1.2 0.7 1.1 -0.9 1.1 0.3 1.1 1.0
Past tobacco smoking 1.2 2.1 5.2 1.8 2.3 -1.6 1.6 0.4 1.0 0.4
Alcohol usually taken with meals 0.1 0.1 0.4 -0.0 -0.6 0.0 -0.5 0.2 0.1 0.3
Nervous feelings 1.4 2.5 4.0 -1.9 -2.0 1.3 -1.4 -1.0 -1.4 -1.9
Frequency of tenseness / restlessness in last 2 weeks 2.6 4.0 8.9 -1.1 -2.7 3.0 -2.5 -0.4 -1.7 -1.1
Hearing difficulty/problems with background noise 0.2 0.4 1.8 -0.1 0.3 -0.2 0.3 1.3 0.8 0.4
Hair/balding pattern: Pattern 2 1.3 1.7 3.4 -1.2 -1.9 1.5 -1.2 -1.1 -0.5 -1.4
Had menopause 0.5 0.6 1.3 -0.9 -1.0 0.5 -0.6 0.4 -0.5 -1.1
Had other major operations 0.2 0.3 0.8 0.4 -0.1 0.3 -0.6 0.2 -0.9 -0.6
Forced vital capacity (FVC) 0.1 0.5 1.3 -0.7 0.0 0.1 -1.2 -0.4 -1.0 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.5 0.5 0.7 -0.8 1.2 0.7 0.6 1.1
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 4.9 -0.1 -0.1 -0.1 1.2 0.9 2.0 2.2
Qualifications: None of the above 0.2 0.5 2.2 0.0 -0.0 0.7 -0.3 1.5 -0.4 0.6
Financial difficulties in last 2 years 0.1 0.2 0.4 0.6 0.6 -0.0 0.5 -0.4 0.1 -0.0
Mouth/teeth dental problems 0.7 1.0 4.0 2.0 0.9 0.0 1.0 -0.4 0.9 0.6
Heart attack 0.2 0.2 0.7 -0.0 -0.8 0.4 -0.2 0.8 0.4 0.1
Allergy 0.6 1.4 2.6 1.5 1.6 -1.4 1.0 -1.3 0.4 0.4
Pain all over the body in last month 0.6 0.6 1.8 -1.1 0.2 -1.0 -0.4 1.3 -0.3 0.2
Diabetes (self-reported) 0.1 0.2 0.6 0.8 0.4 0.4 0.3 0.0 0.1 0.6
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 2.1 -1.4 -0.9 -0.5 -0.0 0.8 0.3 -1.2
Medication: Ramipril 0.4 0.5 1.0 -1.0 -0.7 0.3 0.1 0.9 0.6 1.0
Medication: Simvastatin 3.3 4.9 10.6 -1.4 -2.1 1.7 -2.2 -2.2 -2.2 -3.3
Fluid intelligence score 1.2 2.4 4.9 -2.2 -1.9 1.4 -1.6 0.7 -0.2 -1.8
Illnesses of siblings 0.7 0.9 2.6 -0.8 -1.0 0.5 -0.8 1.6 -0.8 -0.8
Neuroticism score 1.4 2.9 5.9 -1.9 -2.4 2.2 -1.6 -0.0 -1.5 -1.1
Weight 1.0 4.8 8.2 2.7 2.9 -1.7 2.3 2.2 0.6 2.2
Impedance of arm (right) 4.3 20.2 34.7 -5.7 -5.9 2.9 -5.2 -2.5 -3.3 -4.6
Arm fat percentage (right) 0.2 0.8 2.7 1.6 1.2 -0.4 0.8 0.6 -0.6 0.1
Trunk fat-free mass 1.5 8.4 13.5 3.4 3.7 -2.0 3.0 2.5 1.9 3.4
Hip circumference 0.6 2.5 7.5 2.7 2.3 -1.2 1.3 0.7 -0.6 0.7
Time employed in main current job 0.1 0.1 0.4 -0.0 0.1 0.4 0.2 -0.7 0.6 -0.2
Alcohol intake versus 10 years previously 0.3 0.4 1.0 -0.4 -0.3 -1.0 0.2 0.0 -1.0 -0.8
Father’s age at death 0.3 0.4 1.2 0.3 0.6 0.3 -0.7 -1.1 -0.7 -0.4
Worrier / anxious feelings 0.4 0.7 3.7 0.0 -0.7 1.9 -0.6 0.1 -0.7 0.1
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 6.4 -1.0 -2.5 1.9 -1.0 0.2 -0.9 -0.8
Falls in the last year 1.9 2.6 6.9 -1.1 -2.2 2.6 -1.7 0.1 -1.0 -1.1
Hair/balding pattern: Pattern 3 2.6 3.8 8.0 1.2 2.8 -2.3 1.8 1.2 1.4 2.3
Number of live births 0.5 0.7 1.7 0.5 0.3 -0.7 1.3 -0.2 1.3 0.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.2 -0.7 -0.1 -0.3 -1.1 -0.3 -1.0 -0.4
Pulse rate 0.9 1.5 3.7 0.5 1.3 -1.9 1.3 0.2 1.3 1.0
Happiness 0.8 0.9 2.9 -1.7 -1.3 0.6 -0.3 0.5 1.1 -0.4
Noisy workplace 0.8 1.0 5.6 0.5 -0.5 2.4 -0.1 0.2 -0.2 0.8
Qualifications: A levels/AS levels or equivalent 0.3 0.8 2.1 1.3 1.2 -0.3 -0.3 -1.4 0.0 -0.3
Serious illness, injury or assault of a close relative in last 2 years 1.7 1.9 5.2 -1.8 -2.3 1.2 -1.6 -0.4 -0.6 -0.4
Mouth/teeth dental problems: Dentures 1.1 1.8 6.9 -2.6 -1.3 -1.2 0.2 1.7 0.3 -0.0
Asthma 0.5 1.0 4.0 -0.9 -0.8 -0.7 0.1 2.0 0.6 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.6 0.4 0.7 0.4 0.6 0.9 0.5 1.2
Medication: Cholesterol lowering 1.7 2.7 6.0 0.2 -0.4 1.8 -1.2 -2.3 -1.7 -2.4
Depression (self-reported) 0.1 0.2 0.5 -0.4 -0.5 0.1 0.3 0.7 -0.0 -0.3
Medication: Lansoprazole 0.4 0.5 1.5 -1.0 -0.1 -0.8 0.0 1.2 -0.4 0.2
Prospective memory result 2.2 2.8 10.4 3.2 2.4 -0.7 0.8 -1.1 -0.1 0.9
Lung cancer (father) 0.4 0.5 2.3 1.5 0.5 0.4 0.7 -0.3 0.4 0.2
Illnesses of mother 0.1 0.1 0.4 0.1 -0.4 -0.0 -0.0 0.7 -0.3 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.3 -0.1 0.6 -0.4 -0.1 -0.0 -0.0 -0.2
Pulse wave Arterial Stiffness index 0.2 0.3 0.8 0.4 0.5 0.3 -0.6 -0.1 -0.9 -0.5
Impedance of arm (left) 3.8 17.7 33.4 -5.8 -5.8 2.9 -4.7 -1.9 -2.8 -4.0
Arm fat mass (right) 0.7 2.7 5.7 2.4 2.2 -1.1 1.8 1.6 0.2 1.2
Trunk predicted mass 1.6 8.9 14.0 3.4 3.7 -2.1 3.1 2.6 2.0 3.5
Standing height 0.1 1.0 2.4 -1.5 -0.8 -0.3 -1.0 1.5 -0.4 0.5
Length of working week for main job 2.1 2.3 6.4 -1.2 -2.5 1.9 -1.6 -1.1 -0.6 -0.8
Exposure to tobacco smoke at home 0.5 0.5 1.3 0.7 1.2 -1.0 0.6 -0.7 0.3 0.1
Breastfed as a baby 0.5 0.7 1.6 1.2 1.3 -0.4 0.5 0.5 0.4 0.8
Tense / ‘highly strung’ 0.8 1.3 2.2 -0.5 -1.1 1.4 -1.0 -0.9 -1.5 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.5 -0.5 -1.6 0.4 -0.0 0.2 -0.5 -0.7
Hair/balding pattern: Pattern 4 0.0 0.0 0.1 0.2 0.1 -0.0 0.0 -0.0 -0.3 0.2
Birth weight of first child 0.3 0.5 1.6 -0.3 -0.4 -0.4 -0.5 -1.3 -0.8 -0.6
Peak expiratory flow (PEF) 0.7 1.6 3.5 1.4 -0.1 1.5 -1.2 -1.9 -1.5 -0.3
Pulse wave reflection index 0.2 0.3 1.0 0.3 0.2 0.7 -0.3 0.6 -1.0 -0.1
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.2 -1.1 -1.1 0.7 0.0 0.6 0.0 -0.2
Loud music exposure frequency 0.2 0.2 0.6 0.8 0.2 0.1 -0.1 -0.8 -0.2 0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.8 1.2 0.3 -0.4 -0.0 -1.3 0.3 0.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.5 -1.2 -0.2 -0.2 -0.5 1.6 0.0 0.6
Blood clot in the leg (DVT) 1.2 1.5 3.5 1.3 0.9 -0.2 1.6 0.7 1.2 1.9
Medication: Paracetamol 0.2 0.3 1.2 0.4 1.1 0.0 0.4 0.9 0.1 0.3
Headache pain in last month 0.7 1.3 3.5 0.5 -0.2 0.8 -1.1 -1.4 -1.9 -1.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 1.7 -1.1 -0.6 -1.3 -0.1 0.7 0.5 0.3
Glaucoma (self-reported) 1.2 1.4 5.3 -2.3 -0.7 -1.7 0.7 0.6 0.5 -0.4
Gout (self-reported) 0.1 0.2 0.4 0.3 0.4 0.2 -0.3 -0.6 -0.6 -0.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.5 -0.1 -0.5 0.0 -0.4 -0.2 -1.2 -0.5
Medication: Amlodipine 0.1 0.2 1.0 -0.2 0.3 1.0 -0.4 -0.0 -0.1 0.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 0.0 -0.3 0.2 0.5 0.8 1.0 0.9
Birth weight 0.6 1.3 4.0 -0.1 -0.6 0.5 -1.4 -0.4 -2.0 -1.5
Chronic bronchitis/emphysema (mother) 0.5 0.5 2.0 0.5 0.6 0.3 -0.9 0.5 -1.4 -0.2
High blood pressure (siblings) 1.1 1.6 3.9 1.8 1.7 -0.4 0.6 -2.0 0.6 0.8
Forced vital capacity (FVC), Best measure 0.0 0.1 0.4 0.1 0.7 -0.1 -0.3 -0.1 -0.3 -0.6
Body fat percentage 0.2 0.6 1.9 1.4 1.1 -0.2 0.5 0.6 -0.8 -0.0
Leg fat percentage (right) 0.4 1.5 5.2 2.3 1.6 -0.1 1.2 0.9 0.1 0.4
Arm fat-free mass (right) 1.8 9.1 14.3 3.5 3.8 -2.1 3.3 2.8 1.9 3.3
Exposure to tobacco smoke outside home 0.7 1.0 1.9 1.3 0.9 -0.4 1.4 -0.5 0.9 1.0
Comparative body size at age 10 0.6 1.6 6.5 2.5 1.2 -0.0 0.0 -1.4 -0.9 0.7
Number of full brothers 0.8 1.0 2.9 0.2 -1.3 1.7 -1.0 -0.8 -0.1 -1.0
Worry too long after embarrassment 1.0 1.6 3.2 -1.8 -1.7 1.4 -1.5 0.6 -0.7 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.2 1.1 0.6 0.6 0.4 0.0 -0.2 0.0
Wheeze or whistling in the chest in last year 0.1 0.2 0.6 0.8 0.2 -0.3 0.6 0.2 0.4 0.4
Number of children fathered 1.5 1.7 2.6 -0.6 -1.1 1.4 -1.5 1.6 -1.4 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 3.5 1.9 1.2 -0.0 1.3 0.3 1.5 1.6
Age at first live birth 0.4 0.6 1.2 0.8 1.1 -1.0 0.2 -0.4 0.1 1.1
Pulse wave peak to peak time 0.3 0.4 0.9 -0.6 -0.6 -0.3 0.6 0.4 0.9 0.7
Health satisfaction 1.6 2.0 4.1 -1.2 -2.0 1.4 -1.4 0.7 -1.7 -1.2
Shortness of breath walking on level ground 0.2 0.2 0.5 -0.4 -0.7 -0.3 -0.0 0.7 -0.4 -0.3
Qualifications: College or University degree 0.1 0.2 0.5 0.0 -0.2 0.6 -0.6 -0.7 0.1 -0.7
Eye problems/disorders: None of the above 1.9 2.2 6.3 2.5 2.3 0.6 1.2 -0.9 0.8 0.6
Mouth/teeth dental problems: Loose teeth 1.6 1.9 4.7 0.1 -0.3 0.2 -1.6 -1.6 -2.2 -1.7
Emphysema/chronic bronchitis 1.4 1.6 2.6 -0.0 -1.3 1.3 -1.6 -0.8 -1.6 -1.4
Medication for pain relief, constipation, heartburn 0.7 1.1 2.5 -1.0 -1.5 -0.6 -0.8 -1.0 -0.6 -1.6
Neck or shoulder pain in last month 0.3 0.4 0.8 -0.5 -0.9 0.9 0.4 0.8 0.4 0.6
Medication: Blood pressure 0.8 1.4 2.4 0.8 1.0 -0.1 1.4 1.2 1.5 1.6
Angina (self-reported) 2.4 3.2 6.9 -2.1 -2.6 1.7 -1.6 -0.4 -1.8 -1.4
Migraine (self-reported) 0.2 0.3 1.2 -0.3 0.0 -0.9 -0.1 1.1 0.0 0.2
Medication: Ibuprofen 1.2 1.5 3.8 0.0 0.8 -0.4 1.4 1.4 1.4 1.9
Medication: Allopurinol 0.6 0.8 1.9 0.5 0.2 1.1 -1.0 -0.8 -1.4 -0.7
Medication: Omeprazole 1.0 1.1 4.1 0.2 -1.0 2.0 -1.0 -1.0 -0.8 0.6
Medication: Seretide 50 evohaler 1.1 1.3 4.4 -0.6 -0.2 -0.5 -1.5 -1.2 -2.1 -0.6
Mean time to correctly identify matches 0.4 0.8 2.8 -1.4 -0.6 -0.4 -0.2 1.7 -0.1 -0.6
Heart disease (mother) 0.4 0.5 1.8 -1.3 -0.9 0.3 -0.8 -0.7 0.2 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 3.9 -0.9 -1.5 0.4 -1.4 -1.7 -0.2 -2.0
Whole body fat mass 0.6 2.4 5.1 2.3 2.2 -1.0 1.6 1.5 -0.0 1.1
Leg fat mass (right) 0.6 2.4 5.6 2.4 2.1 -0.9 1.7 1.6 0.2 0.9
Arm predicted mass (right) 2.1 10.6 15.8 3.6 4.0 -2.3 3.6 3.3 2.0 3.6
Pulse rate, automated reading 0.4 1.4 5.2 2.3 1.6 0.0 0.4 -1.2 -0.4 0.6
Alcohol intake frequency. 0.0 0.1 0.1 -0.2 0.1 -0.3 0.4 0.3 -0.2 0.2
Comparative height size at age 10 0.9 4.9 13.7 -0.3 2.0 -2.4 1.5 3.7 1.3 2.5
Number of full sisters 0.7 0.8 2.6 0.3 -1.0 1.6 -1.0 -0.1 -0.8 -0.5
Suffer from ‘nerves’ 1.5 2.4 4.6 -2.1 -1.9 0.9 -1.7 -0.6 -1.3 -1.6
Overall health rating 0.2 0.4 1.6 -0.0 -0.8 0.1 0.5 1.3 -0.3 0.3
Chest pain or discomfort 0.1 0.1 0.4 -0.4 -0.6 -0.1 0.3 -0.3 0.2 -0.0
Had major operations 0.7 0.9 4.8 0.1 -0.3 -0.6 0.2 2.2 -0.8 0.2
Age at last live birth 0.6 0.8 4.1 -0.4 0.7 -2.0 0.6 0.4 0.5 0.4
Family relationship satisfaction 0.6 0.7 1.8 -1.3 -1.1 0.7 -0.8 -0.5 -0.2 -0.8
Leg pain on walking 0.6 0.7 3.2 -1.0 -1.0 0.1 -0.1 1.8 -0.0 -0.1
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 3.6 0.6 -0.7 1.4 -0.6 -1.9 -1.5 -1.1
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.1 0.1 -0.4 1.4 -0.6 1.1 -1.1 -0.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.6 -0.1 0.7 -0.6 0.5 0.7 0.8 0.3
Medication: Aspirin 0.2 0.3 1.3 0.2 0.1 1.2 -0.1 0.5 -0.4 -0.0
Supplements: Vitamin C 0.1 0.1 0.5 -0.5 -0.3 -0.7 0.0 -0.4 -0.1 -0.0
Knee pain experienced in last month 0.6 0.9 2.2 -1.4 -1.1 0.4 -0.7 1.5 -0.2 -0.5
Hypertension (Self-reported) 1.4 3.8 7.8 2.0 1.9 -0.4 2.4 1.4 1.8 2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.0 -1.0 -0.2 -0.0 -0.5 0.1 -1.0 -0.1
Illnesses of father: Heart disease 0.1 0.2 0.6 -0.0 -0.8 0.6 -0.0 0.1 -0.0 -0.5
Illnesses of siblings: Diabetes 0.5 0.6 3.9 0.2 0.0 -0.2 0.3 -2.0 0.3 -0.0
Smoking status: Previous 0.6 0.9 1.6 -1.3 -1.2 0.6 -1.2 -0.5 -0.9 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 2.9 0.0 -1.5 1.6 -1.7 -1.0 -1.5 -1.4
Whole body fat-free mass 1.5 8.7 13.4 3.3 3.7 -2.3 3.2 2.6 1.9 3.3
Leg fat-free mass (right) 1.0 5.5 7.9 2.6 2.8 -2.2 2.5 2.3 1.2 2.5
Arm fat percentage (left) 0.2 0.8 2.7 1.6 1.2 -0.2 0.9 0.6 -0.6 0.2
Average weekly red wine intake 0.3 0.4 1.8 -0.4 -0.8 -0.2 -0.4 1.3 -0.3 -0.5
Handedness (chirality/laterality): Left-handed 1.6 2.0 6.0 0.3 -1.0 2.5 -1.7 -0.6 -1.5 -1.1
Mood swings 0.4 0.8 2.6 -0.7 -1.4 1.6 -0.5 0.3 -0.3 0.4
Loneliness, isolation 0.5 0.6 1.7 -0.7 -0.9 1.3 -0.7 0.2 -0.3 -0.8
Long-standing illness, disability or infirmity 0.5 0.7 1.9 -1.4 -1.2 -0.3 0.3 1.2 0.3 0.0
Ever had bowel cancer screening 1.2 1.4 3.3 -0.2 0.6 -1.5 1.1 0.6 1.8 1.5
Diabetes diagnosed by doctor 0.1 0.2 0.7 0.9 0.5 0.5 -0.0 -0.1 -0.2 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.3 -0.1 -0.2 0.3 -0.4 0.1 0.3
Friendships satisfaction 1.6 2.0 4.0 -2.0 -1.7 2.0 -1.5 0.2 -0.2 -0.8
Qualifications: nursing, teaching 0.9 1.4 5.9 2.4 1.6 -0.1 0.3 -0.5 -0.4 0.9
Commuting to job workplace: Walk 0.2 0.3 1.3 -0.1 -0.4 -0.3 0.1 -1.1 0.5 0.3
Eye problems/disorders: Cataract 0.7 0.8 1.6 -1.2 -1.3 -0.4 -0.4 1.2 0.5 0.5
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.5 1.0 0.7 0.8 -0.3 -1.2 -0.6 -0.7
Medication for cholesterol 0.3 0.4 1.1 -0.1 0.2 -0.5 -0.8 -1.0 -0.6 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 2.2 -1.1 -1.5 0.4 -0.4 -0.3 -1.2 -1.0
Back pain experienced in last month 1.7 2.5 6.5 1.8 1.4 -0.6 2.6 -1.0 1.6 1.3
Mineral and other dietary supplements 0.3 0.4 1.1 -1.0 -0.4 -0.2 0.6 0.7 1.0 0.1
Breast cancer (self-reported) 1.0 1.3 3.1 0.5 0.7 -1.4 1.3 0.9 1.7 0.5
Asthma (self-reported) 0.5 0.9 3.4 -1.2 -1.1 -0.6 -0.1 1.8 0.5 0.3
Osteoporosis (self-reported) 0.9 1.2 3.4 -1.8 -1.5 -0.1 -0.4 1.0 0.4 -1.1
Osteoarthritis (self-reported) 1.6 2.0 4.6 -1.2 -2.1 1.7 -1.5 0.9 -1.0 -1.2
Medication: Aspirin 0.2 0.3 0.9 0.6 0.5 1.0 0.4 0.7 -0.1 0.2
Medication: Gliclazide 1.6 1.8 4.9 2.2 0.5 2.2 -0.8 -1.0 -0.9 0.6
Illnesses of father: None of the above (group 1) 0.6 0.7 2.1 -1.5 -1.4 -0.1 -0.2 -0.4 0.1 -0.7
Smoking status: Current 0.7 1.0 4.0 -0.9 -2.0 1.2 -0.7 -0.4 -0.5 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.7 -0.6 -0.0 -0.9 0.3 0.7 0.5 -0.5
Whole body water mass 1.4 8.1 12.3 3.1 3.5 -2.2 3.0 2.6 1.8 3.2
Leg predicted mass (right) 1.0 5.5 7.5 2.5 2.7 -2.1 2.5 2.3 1.3 2.6
Arm fat mass (left) 0.7 3.0 6.3 2.5 2.3 -1.0 1.9 1.8 0.3 1.4
Number of self-reported non-cancer illnesses 1.6 2.8 5.9 -2.4 -2.2 1.1 -1.2 1.8 -0.8 -1.4
Average weekly champagne plus white wine intake 0.6 0.8 3.4 -1.8 -0.7 -0.7 -0.5 0.8 -0.6 -0.5
Miserableness 1.6 2.8 6.4 -2.5 -2.4 1.1 -1.6 0.5 -1.4 -1.3
Guilty feelings 0.4 0.6 4.1 0.2 -0.0 2.0 -0.1 -0.3 0.2 0.5
Wears glasses or contact lenses 0.7 0.9 2.7 -0.5 -0.9 1.6 -1.0 0.8 -0.7 -0.2
Ever taken oral contraceptive pill 1.4 1.6 4.1 -2.0 -1.9 1.1 -0.7 0.5 -0.6 -0.8
Hearing aid user 0.5 0.5 1.1 -0.9 -0.4 -1.0 -0.1 1.1 -0.2 -0.5
Mother’s age at death 1.2 1.5 3.6 -0.6 -1.0 1.6 -1.9 -0.2 -1.3 -1.1
Financial situation satisfaction 0.3 0.4 1.1 -0.0 0.6 -0.5 1.0 -0.3 1.0 0.2
Tinnitus: Yes, now most or all of the time 1.1 1.2 3.0 -0.3 -1.7 1.3 -1.4 -0.6 -1.0 -0.7
Commuting to job workplace: Public transport 1.8 2.2 5.5 -1.9 -2.3 1.2 -1.4 -1.1 -0.9 -0.9
Eye problems/disorders: Glaucoma 0.5 0.6 2.7 -1.6 -0.5 -1.0 0.1 0.3 -0.2 -0.6
Medication: Blood pressure 0.5 1.0 2.6 0.5 0.2 0.4 1.2 1.4 0.8 1.6
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.6 -0.0 0.3 -0.1 0.1 0.8 0.1 0.5
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.7 1.6 1.3 -0.0 -0.0 -0.8 0.1 0.7
High cholesterol (Self-reported) 0.2 0.4 1.4 0.1 -0.6 1.2 -0.4 -0.6 -0.3 -0.7
Medication: Bendroflumethiazide 0.4 0.7 1.9 1.4 0.6 -0.1 1.0 -0.0 0.5 1.1
Medication: Paracetamol 0.4 0.6 3.3 -0.4 0.4 -0.4 0.4 1.8 0.2 0.4
Medication: Lisinopril 0.5 0.6 2.5 -1.0 0.1 -0.2 0.6 1.6 0.4 -0.2
Medication: Atorvastatin 1.4 1.8 3.4 1.2 1.8 -0.1 1.3 0.7 1.5 1.8
Illnesses of father: High blood pressure 0.2 0.3 0.9 0.1 -0.2 0.9 -0.9 -0.3 -0.5 0.3
Alcohol drinker status: Never 1.0 1.2 4.5 0.1 -1.2 2.1 -0.9 -1.1 -0.7 -0.4
Ever smoked 2.2 3.8 7.5 -1.5 -2.7 2.5 -2.3 -1.1 -1.8 -1.0
Basal metabolic rate 1.4 7.6 11.7 3.1 3.4 -2.1 2.9 2.6 1.6 3.0
Leg fat percentage (left) 0.5 1.9 7.4 2.7 1.9 -0.2 1.2 0.6 -0.1 0.4
Arm fat-free mass (left) 1.9 9.5 15.7 3.9 4.0 -2.0 3.3 2.7 1.8 3.3
Number of operations (self-reported) 0.7 1.0 2.6 -0.2 -1.2 0.2 -0.7 1.6 -1.5 0.1
Average weekly beer plus cider intake 0.2 0.3 0.7 0.3 0.6 -0.8 0.4 -0.4 0.2 0.6
Irritability 2.1 3.5 6.5 -1.2 -2.1 1.9 -2.5 -0.6 -2.3 -1.7
Risk taking 1.2 1.8 4.4 -1.8 -2.1 1.2 -1.1 1.0 -0.9 -0.0
Ever had prostate specific antigen (PSA) test 1.1 1.3 4.2 -2.0 -1.0 -0.7 -0.1 1.5 0.9 0.4
Fractured/broken bones in last 5 years 1.0 1.3 3.1 -0.2 0.2 0.6 -1.5 -1.8 -1.3 -1.3
Age started oral contraceptive pill 0.8 1.0 3.2 0.1 0.1 -0.3 1.1 1.1 1.8 1.0
Diastolic blood pressure, automated reading 1.4 4.3 6.8 1.1 2.1 -2.4 2.6 1.8 2.2 2.1
Ever depressed for a whole week 1.1 1.3 5.0 -1.9 -2.2 0.4 0.1 -0.1 0.6 -0.1
Unable to work because of sickness or disability 0.5 0.6 3.5 -0.4 -0.5 -0.2 0.2 1.9 -0.4 -0.1
Commuting to job workplace: Cycle 0.4 0.5 1.7 -0.6 0.2 -0.3 0.6 1.3 1.1 -0.2
Myopia 3.7 5.4 11.6 -0.9 -1.9 1.9 -2.9 -3.4 -2.7 -1.7
Vascular/heart problems diagnosed by doctor 0.9 2.4 5.2 -1.9 -1.4 -0.2 -1.6 -1.6 -0.9 -2.3
Cholesterol lowering medication 0.5 0.7 2.1 -0.9 -1.4 1.1 -0.5 0.4 0.4 -0.3
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 4.8 -0.1 -1.2 2.2 -1.9 -1.1 -1.8 0.2
Pain experienced in last month 0.4 0.6 1.5 0.9 0.8 -0.0 0.5 0.7 0.6 1.2
Supplements: Calcium 0.7 0.8 2.2 -1.5 -0.7 -0.6 -0.2 1.4 0.6 -0.2
Basal cell carcinoma (self-reported) 0.5 0.6 2.0 -1.4 -1.2 -0.6 -0.5 -0.1 0.3 0.1
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.2 -0.3 -1.1 0.5 -0.4 0.9 0.2 -0.1
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 3.1 1.2 0.7 -0.3 1.4 0.8 1.1 1.7
Heart disease (siblings) 0.7 0.9 1.7 0.0 0.8 -1.3 0.9 0.9 1.0 1.1
Alcohol drinker status: Previous 0.4 0.4 1.8 -0.4 0.1 0.0 -0.4 1.4 -0.7 -0.5
Pack years of smoking 1.3 1.9 4.0 -2.0 -1.7 1.4 -1.1 1.7 -0.6 -0.6
Impedance of whole body 3.4 17.4 30.2 -5.3 -5.5 3.1 -4.8 -2.2 -2.9 -4.3
Leg fat mass (left) 0.7 2.6 7.2 2.7 2.2 -0.7 1.6 1.3 -0.1 0.9
Arm predicted mass (left) 1.8 9.1 14.9 3.8 3.9 -2.0 3.2 2.7 1.8 3.2