Hub : Genes

FAN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0900	0.0230	4.0e-10	0.123	0.081	0.111	0.100	0.118	1.1e-14	4.3e-10	1.9e-13	3.7e-12	3.9e-14
2	GTEx	Adipose Subcutaneous	0.0950	0.0330	4.2e-05	0.044	NA	0.064	NA	0.080	1.7e-04	NA	5.9e-06	NA	4.4e-07
3	GTEx	Brain Cerebellum	0.2810	0.0860	1.9e-04	0.300	NA	0.254	NA	0.272	1.6e-09	NA	4.0e-08	NA	1.1e-08
4	GTEx	Lung	0.0446	0.0213	9.0e-03	0.027	NA	0.051	NA	0.047	3.5e-03	NA	9.1e-05	NA	1.5e-04
5	GTEx	Spleen	0.3500	0.1340	7.0e-04	0.144	NA	0.117	NA	0.141	1.6e-04	NA	6.5e-04	NA	1.8e-04
6	GTEx	Whole Blood	0.1520	0.0430	1.4e-08	0.117	NA	0.117	NA	0.084	6.9e-11	NA	6.6e-11	NA	3.8e-08
7	NTR	Blood	0.0197	0.0067	7.7e-06	0.008	0.012	0.016	0.014	0.016	1.1e-03	5.5e-05	5.8e-06	1.8e-05	3.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.2	0.6	-0.2	0.4	-0.7	0.8	0.1	0.0	0.5
Bipolar Disorder or Schizophrenia	0.4	1.0	2.0	0.6	1.4	-1.4	1.1	-0.0	0.4	1.3
Depressed Affect (Nagel 2018)	0.4	0.9	3.7	-1.1	-0.8	0.5	0.2	1.9	0.0	0.5
Depression (Nagel 2018)	0.9	1.4	5.0	-0.6	-0.8	1.4	0.3	2.2	0.6	1.0
Intelligence (Savage-Jansen 2018)	2.1	6.5	12.9	-3.1	-3.0	2.0	-2.7	-0.4	-1.7	-3.6
Neuroticism (Nagel 2018)	0.6	1.3	3.1	-1.8	-1.6	1.1	-0.6	1.1	-0.8	-0.4
Schizophrenia (2018)	0.5	1.1	2.6	0.9	1.6	-1.2	0.8	-0.1	0.7	1.2
Schizophrenia vs Biploar Disorder	0.5	0.7	2.8	1.7	1.0	0.5	-0.5	-0.1	-0.8	-0.2
Worry (Nagel 2018)	1.2	2.5	3.5	-1.6	-1.8	1.2	-1.6	-1.3	-1.9	-1.5
Alzheimer’s Disease (in mother)	2.7	3.2	7.3	-0.8	0.8	-2.7	2.4	1.3	2.3	1.1
Alzheimer’s Disease (in father)	0.6	0.6	1.0	-1.0	-0.6	0.2	-0.9	0.6	-0.9	-1.0
Alzheimer’s Disease (including proxy)	1.0	1.5	3.1	-1.6	-0.4	-1.8	0.9	1.7	1.0	0.0
Crohns Disease (2017)	0.1	0.3	0.7	-0.5	0.1	-0.8	0.9	0.6	-0.3	-0.0
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	0.0	0.2	-0.4	0.6	-0.1	-0.2	0.5
Ulcerative Colitis (UC)	0.2	0.5	1.7	0.5	0.6	-0.3	0.6	-0.1	0.6	1.3
Major Depression (MDD)	2.3	2.7	5.9	-0.9	-1.8	2.4	-1.5	-1.7	-1.0	-1.8
Reaction Time	0.5	1.0	1.7	-1.3	-1.3	0.6	-0.8	0.6	-0.9	-1.3
Verbal and Numeric Reasoning (VNR)	0.9	2.2	6.0	-2.4	-1.9	0.8	-1.1	0.8	0.3	-1.8
Breast Cancer	0.6	1.4	3.4	0.2	1.1	-1.6	1.1	1.8	1.0	0.8
Ovarian Cancer	0.5	0.7	1.7	1.0	1.3	-0.8	0.7	-0.1	0.9	0.5
Prostate Cancer	1.5	2.1	4.7	0.7	1.0	-0.9	1.8	1.9	1.1	2.2
Age at First Birth	0.5	0.8	2.3	0.3	1.2	-0.7	0.6	0.1	0.9	1.5
Bipolar Disorder (2011)	0.7	0.7	1.4	1.0	0.9	-0.4	0.9	-0.1	0.8	1.2
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.5	0.4	0.5	-0.3	-0.8	-0.9	0.1
Coronary Artery Disease (CAD)	0.4	0.5	1.5	0.1	-0.0	-0.9	-0.3	1.2	-0.3	1.0
Crohns Disease (2012)	0.1	0.2	0.7	-0.8	-0.6	-0.2	0.3	0.1	-0.2	0.1
Mean Putamen Volume	0.8	1.0	2.6	-0.3	-0.1	-0.8	1.0	1.1	1.6	1.0
Fasting Glucose	1.1	1.4	3.6	-1.9	-1.9	0.9	-0.9	-0.3	-0.4	-0.7
HbA1C	0.2	0.3	1.0	0.4	1.0	0.7	0.1	0.5	0.1	0.1
HDL Cholesterol	0.5	0.8	2.2	0.4	-0.6	0.1	1.0	1.5	1.1	0.7
LDL Cholesterol	0.5	0.7	1.3	0.5	-0.6	1.1	-0.7	-0.8	-0.9	-1.1
Lupus	0.5	0.7	1.8	-0.5	-0.0	-0.5	-0.6	-1.3	-1.2	-0.9
Neuroticism (2016)	0.4	0.6	1.6	-1.1	-1.3	0.2	-0.5	1.2	0.1	-0.2
Primary Biliary Cirrhosis	0.4	0.5	1.3	-1.1	-0.6	-0.4	0.4	1.1	0.6	0.3
Rheumatoid Arthritis	0.4	0.5	1.0	-0.5	-0.8	0.8	-1.0	-0.1	-0.9	-0.6
Schizophrenia (2014)	0.3	0.6	1.3	0.5	1.2	-0.7	0.6	0.3	0.7	1.1
Triglycerides	0.5	0.7	1.4	-0.3	-0.4	0.9	-1.2	-0.4	-1.2	-1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.5	2.7	-0.4	0.6	-0.4	-0.4	-1.6	0.1	0.3
Ulcerative Colitis	0.4	0.6	2.5	0.5	0.1	-0.1	0.0	-1.6	0.0	1.2
Blood Eosinophil Count	0.1	0.6	1.7	1.1	-0.2	0.8	-0.1	-1.3	-0.2	-0.6
Blood Platelet Count	0.1	1.2	3.8	-2.0	-1.0	0.2	-0.8	1.5	-0.1	-1.0
Blood Red Count	0.2	1.7	3.1	-1.5	-1.3	-0.4	-1.8	-0.3	-1.4	-1.6
Blood White Count	0.2	1.1	2.2	1.0	-0.2	1.5	-0.8	-1.2	-1.4	-0.8
Heel T-Score	0.3	2.2	5.0	-1.0	0.1	-2.0	1.6	2.2	1.6	0.8
BMI	0.9	5.1	10.2	3.1	3.2	-1.3	2.3	1.7	0.7	2.3
Height	0.2	3.1	10.4	-2.0	0.2	-2.1	0.4	3.2	0.9	1.2
Waist Hip Ratio (WHR)	0.2	1.0	2.4	-0.0	0.4	-1.5	0.9	0.5	1.5	0.9
Systolic Blood Pressure	0.4	1.9	3.8	0.5	1.0	-1.4	1.4	1.5	1.6	1.9
Smoking Status	1.1	2.6	5.5	-1.3	-2.4	1.5	-1.4	-1.5	-1.5	-1.6
Allergy or Eczema	0.4	1.1	2.5	-1.6	-1.2	0.6	-0.9	0.2	-0.7	-1.3
Cardiovascular Disease	0.7	2.4	6.3	2.5	1.5	0.3	1.6	0.7	0.8	2.1
Hypothyroidism (self reported)	0.4	0.9	2.3	-0.8	-1.0	0.1	-0.9	-0.1	-1.5	-1.1
Respiratory disease	0.3	0.6	3.0	-0.6	-0.6	-0.2	-0.1	1.7	0.5	0.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.9	1.2	1.1	-0.5	1.4	-0.3	0.8	1.1
Lung FEV1/FVC ratio	0.7	3.5	7.2	-0.6	0.3	-2.2	1.8	2.7	1.5	2.5
Lung FVC	0.1	0.6	1.1	-0.4	-0.4	0.3	-0.8	-1.0	-1.1	-0.9
Neuroticism	1.1	2.7	5.8	-1.8	-2.4	1.8	-1.5	-0.2	-1.7	-1.2
Chronotype (morning person)	0.4	1.0	2.8	1.7	0.5	0.7	-0.5	-0.8	-1.3	-0.6
Hair Pigment	0.1	3.9	11.0	0.3	-0.5	0.7	-2.3	-2.7	-3.3	-1.7
Tanning	0.3	3.7	12.3	-3.5	-1.8	-0.6	0.3	1.6	2.1	1.7
Hand grip strength (left)	0.2	0.6	1.2	0.4	0.0	0.7	-1.1	-1.1	-0.8	-0.9
Number of treatments/medications taken	0.6	1.0	5.5	-0.5	-0.5	0.6	0.6	2.3	0.4	0.4
Average weekly spirits intake	0.9	1.1	3.1	-0.6	-0.7	0.8	-1.4	-0.6	-1.8	-1.1
Sensitivity / hurt feelings	1.2	2.0	6.2	-2.2	-2.5	1.2	-0.3	0.8	-0.5	-1.0
Frequency of depressed mood in last 2 weeks	1.7	2.3	9.4	-0.7	-2.2	3.1	-1.2	0.3	-0.6	-0.3
Hearing difficulty/problems: Yes	0.6	0.9	2.2	-0.0	-0.6	1.5	-1.2	0.5	-1.3	-0.5
Relative age of first facial hair	0.4	0.9	2.2	-1.3	-1.5	0.7	-1.1	0.4	0.2	-0.4
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	4.7	-2.2	-1.5	-0.3	-0.2	1.3	-0.2	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	0.6	-0.5	0.9	-0.1	-1.1	-0.5	0.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.8	0.1	0.2	0.6	-0.6	0.2	0.2
Systolic blood pressure, automated reading	1.4	4.0	5.4	0.7	2.1	-2.3	2.1	2.2	2.0	2.0
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	4.0	-0.5	-1.4	2.0	-1.2	0.3	-0.7	-0.5
Angina	2.8	3.7	8.1	-2.4	-2.9	1.7	-1.8	-0.2	-1.9	-1.5
Medication for hormone replacement therapy	0.3	0.3	1.2	-0.3	-0.2	0.1	-0.4	-0.7	-1.1	-0.5
Vitamin and mineral supplements	0.1	0.1	0.5	-0.2	-0.0	-0.1	-0.1	-0.1	0.7	0.5
Supplements: Zinc	0.6	0.6	1.6	0.8	-0.3	0.7	-0.4	-1.2	-1.1	0.0
Medication: Co-codamol	0.5	0.6	2.1	-0.1	-0.5	0.4	0.5	1.5	0.8	0.8
Medication: Metformin	0.2	0.3	0.8	0.7	0.9	-0.2	0.8	0.0	-0.0	0.2
Diabetes (father)	1.2	1.5	3.6	1.7	0.9	-0.6	1.2	0.4	1.2	1.9
Diabetes (mother)	0.1	0.1	0.3	0.2	0.0	0.0	0.4	-0.3	0.3	0.5
Severe depression (siblings)	0.3	0.3	1.6	0.0	-0.4	-0.2	0.3	0.3	0.6	1.3
Pack years adult smoking proportion	0.9	1.4	2.6	-1.6	-1.4	1.2	-0.9	1.5	-0.5	-0.5
Impedance of leg (right)	2.3	11.1	20.3	-4.2	-4.5	2.8	-3.7	-1.7	-1.8	-3.4
Leg fat-free mass (left)	1.2	6.5	8.7	2.4	2.9	-2.3	2.9	2.7	1.7	2.7
Trunk fat percentage	0.1	0.4	1.1	0.7	0.7	-0.3	0.2	1.1	-0.9	0.0
Hand grip strength (right)	0.1	0.4	1.0	0.0	-0.2	0.1	-0.6	-0.9	-0.6	-1.0
Townsend deprivation index at recruitment	0.6	0.8	3.5	-0.4	-0.4	-0.7	-0.4	-1.9	-0.3	-1.2
Current tobacco smoking	0.6	1.0	3.6	-0.6	-1.9	1.1	-0.8	-0.6	-0.7	-0.5
Average weekly fortified wine intake	0.3	0.3	1.1	-0.7	0.4	-1.0	-0.4	-0.5	-0.6	-0.1
Maternal smoking around birth	0.2	0.2	0.6	0.7	-0.4	0.3	0.2	0.4	-0.8	0.0
Fed-up feelings	0.3	0.6	1.5	-1.0	-1.2	0.9	-0.3	0.9	-0.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	4.0	-0.3	-1.2	2.0	-0.4	0.6	-0.5	-0.6
Relative age voice broke	0.9	1.4	3.5	-0.9	-1.9	1.4	-1.5	-0.2	-0.6	-0.8
Taking other prescription medications	1.0	1.6	5.5	-1.1	-1.1	-0.7	0.8	2.3	0.5	1.2
Age when periods started (menarche)	0.7	1.6	4.7	-1.8	-2.2	0.4	-1.1	-0.4	-0.4	-1.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.9	0.3	-1.4	1.7	-0.7	-1.1	-1.0	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.2	0.2	0.5	-0.3	0.7	0.3	0.7	1.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.8	-1.4	-1.7	0.7	-0.6	-0.8	-0.7	-1.0
Qualifications: CSEs or equivalent	3.2	4.3	7.3	-0.7	-2.2	2.2	-1.9	-2.7	-2.1	-2.0
Serious illness, injury or assault to yourself	0.3	0.3	1.1	-0.7	-0.7	0.0	0.1	1.0	-0.1	-0.4
High blood pressure	1.5	4.1	9.1	2.1	2.1	-0.4	2.4	1.5	1.6	3.0
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.1	-1.8	-1.6	1.2	-1.4	-0.0	-1.1	-1.4
Multivitamins +/- minerals	0.1	0.1	0.5	0.3	0.4	0.1	0.1	0.7	-0.2	0.1
Stomach or abdominal pain in last month	2.0	2.5	3.1	-1.7	-1.6	1.7	-1.8	-0.1	-1.7	-1.7
Supplements: Glucosamine	0.7	1.0	2.3	0.6	0.9	-1.1	1.0	1.5	0.5	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	-0.6	-0.7	0.0	-0.8	-0.3	-1.0	-1.2
Medication: Atenolol	0.1	0.1	0.6	0.4	-0.3	0.8	0.2	-0.1	-0.1	0.2
Medication: Levothyroxine sodium	0.2	0.3	1.7	0.6	-0.0	0.1	-0.1	-0.0	-1.3	-0.3
Sitting height	0.1	0.4	1.7	0.2	0.3	0.5	-0.9	0.0	-1.3	-0.1
Chronic bronchitis/emphysema (father)	2.1	2.5	5.2	0.5	1.4	-1.2	1.7	1.6	2.3	1.6
High blood pressure (mother)	0.3	0.4	1.0	0.4	0.6	-0.5	0.6	-1.0	0.9	0.4
Body mass index (BMI)	1.5	6.3	14.2	3.8	3.5	-1.5	2.9	1.4	0.8	2.1
Impedance of leg (left)	2.4	11.4	18.5	-3.7	-4.3	2.9	-4.0	-2.2	-2.4	-3.6
Leg predicted mass (left)	1.2	6.4	8.8	2.5	3.0	-2.3	2.8	2.6	1.6	2.7
Trunk fat mass	0.3	1.5	2.8	1.6	1.7	-0.9	1.0	1.6	-0.4	0.7
Waist circumference	0.9	3.4	6.8	2.6	2.4	-1.5	2.0	1.7	0.3	1.3
Number of incorrect matches in round	0.5	0.8	1.2	0.7	1.1	-0.9	1.1	0.3	1.1	1.0
Past tobacco smoking	1.2	2.1	5.2	1.8	2.3	-1.6	1.6	0.4	1.0	0.4
Alcohol usually taken with meals	0.1	0.1	0.4	-0.0	-0.6	0.0	-0.5	0.2	0.1	0.3
Nervous feelings	1.4	2.5	4.0	-1.9	-2.0	1.3	-1.4	-1.0	-1.4	-1.9
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.0	8.9	-1.1	-2.7	3.0	-2.5	-0.4	-1.7	-1.1
Hearing difficulty/problems with background noise	0.2	0.4	1.8	-0.1	0.3	-0.2	0.3	1.3	0.8	0.4
Hair/balding pattern: Pattern 2	1.3	1.7	3.4	-1.2	-1.9	1.5	-1.2	-1.1	-0.5	-1.4
Had menopause	0.5	0.6	1.3	-0.9	-1.0	0.5	-0.6	0.4	-0.5	-1.1
Had other major operations	0.2	0.3	0.8	0.4	-0.1	0.3	-0.6	0.2	-0.9	-0.6
Forced vital capacity (FVC)	0.1	0.5	1.3	-0.7	0.0	0.1	-1.2	-0.4	-1.0	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.5	0.5	0.7	-0.8	1.2	0.7	0.6	1.1
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.9	-0.1	-0.1	-0.1	1.2	0.9	2.0	2.2
Qualifications: None of the above	0.2	0.5	2.2	0.0	-0.0	0.7	-0.3	1.5	-0.4	0.6
Financial difficulties in last 2 years	0.1	0.2	0.4	0.6	0.6	-0.0	0.5	-0.4	0.1	-0.0
Mouth/teeth dental problems	0.7	1.0	4.0	2.0	0.9	0.0	1.0	-0.4	0.9	0.6
Heart attack	0.2	0.2	0.7	-0.0	-0.8	0.4	-0.2	0.8	0.4	0.1
Allergy	0.6	1.4	2.6	1.5	1.6	-1.4	1.0	-1.3	0.4	0.4
Pain all over the body in last month	0.6	0.6	1.8	-1.1	0.2	-1.0	-0.4	1.3	-0.3	0.2
Diabetes (self-reported)	0.1	0.2	0.6	0.8	0.4	0.4	0.3	0.0	0.1	0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.1	-1.4	-0.9	-0.5	-0.0	0.8	0.3	-1.2
Medication: Ramipril	0.4	0.5	1.0	-1.0	-0.7	0.3	0.1	0.9	0.6	1.0
Medication: Simvastatin	3.3	4.9	10.6	-1.4	-2.1	1.7	-2.2	-2.2	-2.2	-3.3
Fluid intelligence score	1.2	2.4	4.9	-2.2	-1.9	1.4	-1.6	0.7	-0.2	-1.8
Illnesses of siblings	0.7	0.9	2.6	-0.8	-1.0	0.5	-0.8	1.6	-0.8	-0.8
Neuroticism score	1.4	2.9	5.9	-1.9	-2.4	2.2	-1.6	-0.0	-1.5	-1.1
Weight	1.0	4.8	8.2	2.7	2.9	-1.7	2.3	2.2	0.6	2.2
Impedance of arm (right)	4.3	20.2	34.7	-5.7	-5.9	2.9	-5.2	-2.5	-3.3	-4.6
Arm fat percentage (right)	0.2	0.8	2.7	1.6	1.2	-0.4	0.8	0.6	-0.6	0.1
Trunk fat-free mass	1.5	8.4	13.5	3.4	3.7	-2.0	3.0	2.5	1.9	3.4
Hip circumference	0.6	2.5	7.5	2.7	2.3	-1.2	1.3	0.7	-0.6	0.7
Time employed in main current job	0.1	0.1	0.4	-0.0	0.1	0.4	0.2	-0.7	0.6	-0.2
Alcohol intake versus 10 years previously	0.3	0.4	1.0	-0.4	-0.3	-1.0	0.2	0.0	-1.0	-0.8
Father’s age at death	0.3	0.4	1.2	0.3	0.6	0.3	-0.7	-1.1	-0.7	-0.4
Worrier / anxious feelings	0.4	0.7	3.7	0.0	-0.7	1.9	-0.6	0.1	-0.7	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	6.4	-1.0	-2.5	1.9	-1.0	0.2	-0.9	-0.8
Falls in the last year	1.9	2.6	6.9	-1.1	-2.2	2.6	-1.7	0.1	-1.0	-1.1
Hair/balding pattern: Pattern 3	2.6	3.8	8.0	1.2	2.8	-2.3	1.8	1.2	1.4	2.3
Number of live births	0.5	0.7	1.7	0.5	0.3	-0.7	1.3	-0.2	1.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.2	-0.7	-0.1	-0.3	-1.1	-0.3	-1.0	-0.4
Pulse rate	0.9	1.5	3.7	0.5	1.3	-1.9	1.3	0.2	1.3	1.0
Happiness	0.8	0.9	2.9	-1.7	-1.3	0.6	-0.3	0.5	1.1	-0.4
Noisy workplace	0.8	1.0	5.6	0.5	-0.5	2.4	-0.1	0.2	-0.2	0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.1	1.3	1.2	-0.3	-0.3	-1.4	0.0	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	5.2	-1.8	-2.3	1.2	-1.6	-0.4	-0.6	-0.4
Mouth/teeth dental problems: Dentures	1.1	1.8	6.9	-2.6	-1.3	-1.2	0.2	1.7	0.3	-0.0
Asthma	0.5	1.0	4.0	-0.9	-0.8	-0.7	0.1	2.0	0.6	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.6	0.4	0.7	0.4	0.6	0.9	0.5	1.2
Medication: Cholesterol lowering	1.7	2.7	6.0	0.2	-0.4	1.8	-1.2	-2.3	-1.7	-2.4
Depression (self-reported)	0.1	0.2	0.5	-0.4	-0.5	0.1	0.3	0.7	-0.0	-0.3
Medication: Lansoprazole	0.4	0.5	1.5	-1.0	-0.1	-0.8	0.0	1.2	-0.4	0.2
Prospective memory result	2.2	2.8	10.4	3.2	2.4	-0.7	0.8	-1.1	-0.1	0.9
Lung cancer (father)	0.4	0.5	2.3	1.5	0.5	0.4	0.7	-0.3	0.4	0.2
Illnesses of mother	0.1	0.1	0.4	0.1	-0.4	-0.0	-0.0	0.7	-0.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	-0.1	0.6	-0.4	-0.1	-0.0	-0.0	-0.2
Pulse wave Arterial Stiffness index	0.2	0.3	0.8	0.4	0.5	0.3	-0.6	-0.1	-0.9	-0.5
Impedance of arm (left)	3.8	17.7	33.4	-5.8	-5.8	2.9	-4.7	-1.9	-2.8	-4.0
Arm fat mass (right)	0.7	2.7	5.7	2.4	2.2	-1.1	1.8	1.6	0.2	1.2
Trunk predicted mass	1.6	8.9	14.0	3.4	3.7	-2.1	3.1	2.6	2.0	3.5
Standing height	0.1	1.0	2.4	-1.5	-0.8	-0.3	-1.0	1.5	-0.4	0.5
Length of working week for main job	2.1	2.3	6.4	-1.2	-2.5	1.9	-1.6	-1.1	-0.6	-0.8
Exposure to tobacco smoke at home	0.5	0.5	1.3	0.7	1.2	-1.0	0.6	-0.7	0.3	0.1
Breastfed as a baby	0.5	0.7	1.6	1.2	1.3	-0.4	0.5	0.5	0.4	0.8
Tense / ‘highly strung’	0.8	1.3	2.2	-0.5	-1.1	1.4	-1.0	-0.9	-1.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.5	-0.5	-1.6	0.4	-0.0	0.2	-0.5	-0.7
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.2	0.1	-0.0	0.0	-0.0	-0.3	0.2
Birth weight of first child	0.3	0.5	1.6	-0.3	-0.4	-0.4	-0.5	-1.3	-0.8	-0.6
Peak expiratory flow (PEF)	0.7	1.6	3.5	1.4	-0.1	1.5	-1.2	-1.9	-1.5	-0.3
Pulse wave reflection index	0.2	0.3	1.0	0.3	0.2	0.7	-0.3	0.6	-1.0	-0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	-1.1	-1.1	0.7	0.0	0.6	0.0	-0.2
Loud music exposure frequency	0.2	0.2	0.6	0.8	0.2	0.1	-0.1	-0.8	-0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.8	1.2	0.3	-0.4	-0.0	-1.3	0.3	0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.5	-1.2	-0.2	-0.2	-0.5	1.6	0.0	0.6
Blood clot in the leg (DVT)	1.2	1.5	3.5	1.3	0.9	-0.2	1.6	0.7	1.2	1.9
Medication: Paracetamol	0.2	0.3	1.2	0.4	1.1	0.0	0.4	0.9	0.1	0.3
Headache pain in last month	0.7	1.3	3.5	0.5	-0.2	0.8	-1.1	-1.4	-1.9	-1.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.7	-1.1	-0.6	-1.3	-0.1	0.7	0.5	0.3
Glaucoma (self-reported)	1.2	1.4	5.3	-2.3	-0.7	-1.7	0.7	0.6	0.5	-0.4
Gout (self-reported)	0.1	0.2	0.4	0.3	0.4	0.2	-0.3	-0.6	-0.6	-0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.5	-0.1	-0.5	0.0	-0.4	-0.2	-1.2	-0.5
Medication: Amlodipine	0.1	0.2	1.0	-0.2	0.3	1.0	-0.4	-0.0	-0.1	0.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.0	-0.3	0.2	0.5	0.8	1.0	0.9
Birth weight	0.6	1.3	4.0	-0.1	-0.6	0.5	-1.4	-0.4	-2.0	-1.5
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.0	0.5	0.6	0.3	-0.9	0.5	-1.4	-0.2
High blood pressure (siblings)	1.1	1.6	3.9	1.8	1.7	-0.4	0.6	-2.0	0.6	0.8
Forced vital capacity (FVC), Best measure	0.0	0.1	0.4	0.1	0.7	-0.1	-0.3	-0.1	-0.3	-0.6
Body fat percentage	0.2	0.6	1.9	1.4	1.1	-0.2	0.5	0.6	-0.8	-0.0
Leg fat percentage (right)	0.4	1.5	5.2	2.3	1.6	-0.1	1.2	0.9	0.1	0.4
Arm fat-free mass (right)	1.8	9.1	14.3	3.5	3.8	-2.1	3.3	2.8	1.9	3.3
Exposure to tobacco smoke outside home	0.7	1.0	1.9	1.3	0.9	-0.4	1.4	-0.5	0.9	1.0
Comparative body size at age 10	0.6	1.6	6.5	2.5	1.2	-0.0	0.0	-1.4	-0.9	0.7
Number of full brothers	0.8	1.0	2.9	0.2	-1.3	1.7	-1.0	-0.8	-0.1	-1.0
Worry too long after embarrassment	1.0	1.6	3.2	-1.8	-1.7	1.4	-1.5	0.6	-0.7	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.2	1.1	0.6	0.6	0.4	0.0	-0.2	0.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	0.8	0.2	-0.3	0.6	0.2	0.4	0.4
Number of children fathered	1.5	1.7	2.6	-0.6	-1.1	1.4	-1.5	1.6	-1.4	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.5	1.9	1.2	-0.0	1.3	0.3	1.5	1.6
Age at first live birth	0.4	0.6	1.2	0.8	1.1	-1.0	0.2	-0.4	0.1	1.1
Pulse wave peak to peak time	0.3	0.4	0.9	-0.6	-0.6	-0.3	0.6	0.4	0.9	0.7
Health satisfaction	1.6	2.0	4.1	-1.2	-2.0	1.4	-1.4	0.7	-1.7	-1.2
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.4	-0.7	-0.3	-0.0	0.7	-0.4	-0.3
Qualifications: College or University degree	0.1	0.2	0.5	0.0	-0.2	0.6	-0.6	-0.7	0.1	-0.7
Eye problems/disorders: None of the above	1.9	2.2	6.3	2.5	2.3	0.6	1.2	-0.9	0.8	0.6
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.7	0.1	-0.3	0.2	-1.6	-1.6	-2.2	-1.7
Emphysema/chronic bronchitis	1.4	1.6	2.6	-0.0	-1.3	1.3	-1.6	-0.8	-1.6	-1.4
Medication for pain relief, constipation, heartburn	0.7	1.1	2.5	-1.0	-1.5	-0.6	-0.8	-1.0	-0.6	-1.6
Neck or shoulder pain in last month	0.3	0.4	0.8	-0.5	-0.9	0.9	0.4	0.8	0.4	0.6
Medication: Blood pressure	0.8	1.4	2.4	0.8	1.0	-0.1	1.4	1.2	1.5	1.6
Angina (self-reported)	2.4	3.2	6.9	-2.1	-2.6	1.7	-1.6	-0.4	-1.8	-1.4
Migraine (self-reported)	0.2	0.3	1.2	-0.3	0.0	-0.9	-0.1	1.1	0.0	0.2
Medication: Ibuprofen	1.2	1.5	3.8	0.0	0.8	-0.4	1.4	1.4	1.4	1.9
Medication: Allopurinol	0.6	0.8	1.9	0.5	0.2	1.1	-1.0	-0.8	-1.4	-0.7
Medication: Omeprazole	1.0	1.1	4.1	0.2	-1.0	2.0	-1.0	-1.0	-0.8	0.6
Medication: Seretide 50 evohaler	1.1	1.3	4.4	-0.6	-0.2	-0.5	-1.5	-1.2	-2.1	-0.6
Mean time to correctly identify matches	0.4	0.8	2.8	-1.4	-0.6	-0.4	-0.2	1.7	-0.1	-0.6
Heart disease (mother)	0.4	0.5	1.8	-1.3	-0.9	0.3	-0.8	-0.7	0.2	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.9	-0.9	-1.5	0.4	-1.4	-1.7	-0.2	-2.0
Whole body fat mass	0.6	2.4	5.1	2.3	2.2	-1.0	1.6	1.5	-0.0	1.1
Leg fat mass (right)	0.6	2.4	5.6	2.4	2.1	-0.9	1.7	1.6	0.2	0.9
Arm predicted mass (right)	2.1	10.6	15.8	3.6	4.0	-2.3	3.6	3.3	2.0	3.6
Pulse rate, automated reading	0.4	1.4	5.2	2.3	1.6	0.0	0.4	-1.2	-0.4	0.6
Alcohol intake frequency.	0.0	0.1	0.1	-0.2	0.1	-0.3	0.4	0.3	-0.2	0.2
Comparative height size at age 10	0.9	4.9	13.7	-0.3	2.0	-2.4	1.5	3.7	1.3	2.5
Number of full sisters	0.7	0.8	2.6	0.3	-1.0	1.6	-1.0	-0.1	-0.8	-0.5
Suffer from ‘nerves’	1.5	2.4	4.6	-2.1	-1.9	0.9	-1.7	-0.6	-1.3	-1.6
Overall health rating	0.2	0.4	1.6	-0.0	-0.8	0.1	0.5	1.3	-0.3	0.3
Chest pain or discomfort	0.1	0.1	0.4	-0.4	-0.6	-0.1	0.3	-0.3	0.2	-0.0
Had major operations	0.7	0.9	4.8	0.1	-0.3	-0.6	0.2	2.2	-0.8	0.2
Age at last live birth	0.6	0.8	4.1	-0.4	0.7	-2.0	0.6	0.4	0.5	0.4
Family relationship satisfaction	0.6	0.7	1.8	-1.3	-1.1	0.7	-0.8	-0.5	-0.2	-0.8
Leg pain on walking	0.6	0.7	3.2	-1.0	-1.0	0.1	-0.1	1.8	-0.0	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.6	0.6	-0.7	1.4	-0.6	-1.9	-1.5	-1.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.1	0.1	-0.4	1.4	-0.6	1.1	-1.1	-0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	-0.1	0.7	-0.6	0.5	0.7	0.8	0.3
Medication: Aspirin	0.2	0.3	1.3	0.2	0.1	1.2	-0.1	0.5	-0.4	-0.0
Supplements: Vitamin C	0.1	0.1	0.5	-0.5	-0.3	-0.7	0.0	-0.4	-0.1	-0.0
Knee pain experienced in last month	0.6	0.9	2.2	-1.4	-1.1	0.4	-0.7	1.5	-0.2	-0.5
Hypertension (Self-reported)	1.4	3.8	7.8	2.0	1.9	-0.4	2.4	1.4	1.8	2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.0	-1.0	-0.2	-0.0	-0.5	0.1	-1.0	-0.1
Illnesses of father: Heart disease	0.1	0.2	0.6	-0.0	-0.8	0.6	-0.0	0.1	-0.0	-0.5
Illnesses of siblings: Diabetes	0.5	0.6	3.9	0.2	0.0	-0.2	0.3	-2.0	0.3	-0.0
Smoking status: Previous	0.6	0.9	1.6	-1.3	-1.2	0.6	-1.2	-0.5	-0.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	2.9	0.0	-1.5	1.6	-1.7	-1.0	-1.5	-1.4
Whole body fat-free mass	1.5	8.7	13.4	3.3	3.7	-2.3	3.2	2.6	1.9	3.3
Leg fat-free mass (right)	1.0	5.5	7.9	2.6	2.8	-2.2	2.5	2.3	1.2	2.5
Arm fat percentage (left)	0.2	0.8	2.7	1.6	1.2	-0.2	0.9	0.6	-0.6	0.2
Average weekly red wine intake	0.3	0.4	1.8	-0.4	-0.8	-0.2	-0.4	1.3	-0.3	-0.5
Handedness (chirality/laterality): Left-handed	1.6	2.0	6.0	0.3	-1.0	2.5	-1.7	-0.6	-1.5	-1.1
Mood swings	0.4	0.8	2.6	-0.7	-1.4	1.6	-0.5	0.3	-0.3	0.4
Loneliness, isolation	0.5	0.6	1.7	-0.7	-0.9	1.3	-0.7	0.2	-0.3	-0.8
Long-standing illness, disability or infirmity	0.5	0.7	1.9	-1.4	-1.2	-0.3	0.3	1.2	0.3	0.0
Ever had bowel cancer screening	1.2	1.4	3.3	-0.2	0.6	-1.5	1.1	0.6	1.8	1.5
Diabetes diagnosed by doctor	0.1	0.2	0.7	0.9	0.5	0.5	-0.0	-0.1	-0.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.3	-0.1	-0.2	0.3	-0.4	0.1	0.3
Friendships satisfaction	1.6	2.0	4.0	-2.0	-1.7	2.0	-1.5	0.2	-0.2	-0.8
Qualifications: nursing, teaching	0.9	1.4	5.9	2.4	1.6	-0.1	0.3	-0.5	-0.4	0.9
Commuting to job workplace: Walk	0.2	0.3	1.3	-0.1	-0.4	-0.3	0.1	-1.1	0.5	0.3
Eye problems/disorders: Cataract	0.7	0.8	1.6	-1.2	-1.3	-0.4	-0.4	1.2	0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	1.0	0.7	0.8	-0.3	-1.2	-0.6	-0.7
Medication for cholesterol	0.3	0.4	1.1	-0.1	0.2	-0.5	-0.8	-1.0	-0.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.2	-1.1	-1.5	0.4	-0.4	-0.3	-1.2	-1.0
Back pain experienced in last month	1.7	2.5	6.5	1.8	1.4	-0.6	2.6	-1.0	1.6	1.3
Mineral and other dietary supplements	0.3	0.4	1.1	-1.0	-0.4	-0.2	0.6	0.7	1.0	0.1
Breast cancer (self-reported)	1.0	1.3	3.1	0.5	0.7	-1.4	1.3	0.9	1.7	0.5
Asthma (self-reported)	0.5	0.9	3.4	-1.2	-1.1	-0.6	-0.1	1.8	0.5	0.3
Osteoporosis (self-reported)	0.9	1.2	3.4	-1.8	-1.5	-0.1	-0.4	1.0	0.4	-1.1
Osteoarthritis (self-reported)	1.6	2.0	4.6	-1.2	-2.1	1.7	-1.5	0.9	-1.0	-1.2
Medication: Aspirin	0.2	0.3	0.9	0.6	0.5	1.0	0.4	0.7	-0.1	0.2
Medication: Gliclazide	1.6	1.8	4.9	2.2	0.5	2.2	-0.8	-1.0	-0.9	0.6
Illnesses of father: None of the above (group 1)	0.6	0.7	2.1	-1.5	-1.4	-0.1	-0.2	-0.4	0.1	-0.7
Smoking status: Current	0.7	1.0	4.0	-0.9	-2.0	1.2	-0.7	-0.4	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.7	-0.6	-0.0	-0.9	0.3	0.7	0.5	-0.5
Whole body water mass	1.4	8.1	12.3	3.1	3.5	-2.2	3.0	2.6	1.8	3.2
Leg predicted mass (right)	1.0	5.5	7.5	2.5	2.7	-2.1	2.5	2.3	1.3	2.6
Arm fat mass (left)	0.7	3.0	6.3	2.5	2.3	-1.0	1.9	1.8	0.3	1.4
Number of self-reported non-cancer illnesses	1.6	2.8	5.9	-2.4	-2.2	1.1	-1.2	1.8	-0.8	-1.4
Average weekly champagne plus white wine intake	0.6	0.8	3.4	-1.8	-0.7	-0.7	-0.5	0.8	-0.6	-0.5
Miserableness	1.6	2.8	6.4	-2.5	-2.4	1.1	-1.6	0.5	-1.4	-1.3
Guilty feelings	0.4	0.6	4.1	0.2	-0.0	2.0	-0.1	-0.3	0.2	0.5
Wears glasses or contact lenses	0.7	0.9	2.7	-0.5	-0.9	1.6	-1.0	0.8	-0.7	-0.2
Ever taken oral contraceptive pill	1.4	1.6	4.1	-2.0	-1.9	1.1	-0.7	0.5	-0.6	-0.8
Hearing aid user	0.5	0.5	1.1	-0.9	-0.4	-1.0	-0.1	1.1	-0.2	-0.5
Mother’s age at death	1.2	1.5	3.6	-0.6	-1.0	1.6	-1.9	-0.2	-1.3	-1.1
Financial situation satisfaction	0.3	0.4	1.1	-0.0	0.6	-0.5	1.0	-0.3	1.0	0.2
Tinnitus: Yes, now most or all of the time	1.1	1.2	3.0	-0.3	-1.7	1.3	-1.4	-0.6	-1.0	-0.7
Commuting to job workplace: Public transport	1.8	2.2	5.5	-1.9	-2.3	1.2	-1.4	-1.1	-0.9	-0.9
Eye problems/disorders: Glaucoma	0.5	0.6	2.7	-1.6	-0.5	-1.0	0.1	0.3	-0.2	-0.6
Medication: Blood pressure	0.5	1.0	2.6	0.5	0.2	0.4	1.2	1.4	0.8	1.6
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.6	-0.0	0.3	-0.1	0.1	0.8	0.1	0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.7	1.6	1.3	-0.0	-0.0	-0.8	0.1	0.7
High cholesterol (Self-reported)	0.2	0.4	1.4	0.1	-0.6	1.2	-0.4	-0.6	-0.3	-0.7
Medication: Bendroflumethiazide	0.4	0.7	1.9	1.4	0.6	-0.1	1.0	-0.0	0.5	1.1
Medication: Paracetamol	0.4	0.6	3.3	-0.4	0.4	-0.4	0.4	1.8	0.2	0.4
Medication: Lisinopril	0.5	0.6	2.5	-1.0	0.1	-0.2	0.6	1.6	0.4	-0.2
Medication: Atorvastatin	1.4	1.8	3.4	1.2	1.8	-0.1	1.3	0.7	1.5	1.8
Illnesses of father: High blood pressure	0.2	0.3	0.9	0.1	-0.2	0.9	-0.9	-0.3	-0.5	0.3
Alcohol drinker status: Never	1.0	1.2	4.5	0.1	-1.2	2.1	-0.9	-1.1	-0.7	-0.4
Ever smoked	2.2	3.8	7.5	-1.5	-2.7	2.5	-2.3	-1.1	-1.8	-1.0
Basal metabolic rate	1.4	7.6	11.7	3.1	3.4	-2.1	2.9	2.6	1.6	3.0
Leg fat percentage (left)	0.5	1.9	7.4	2.7	1.9	-0.2	1.2	0.6	-0.1	0.4
Arm fat-free mass (left)	1.9	9.5	15.7	3.9	4.0	-2.0	3.3	2.7	1.8	3.3
Number of operations (self-reported)	0.7	1.0	2.6	-0.2	-1.2	0.2	-0.7	1.6	-1.5	0.1
Average weekly beer plus cider intake	0.2	0.3	0.7	0.3	0.6	-0.8	0.4	-0.4	0.2	0.6
Irritability	2.1	3.5	6.5	-1.2	-2.1	1.9	-2.5	-0.6	-2.3	-1.7
Risk taking	1.2	1.8	4.4	-1.8	-2.1	1.2	-1.1	1.0	-0.9	-0.0
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.2	-2.0	-1.0	-0.7	-0.1	1.5	0.9	0.4
Fractured/broken bones in last 5 years	1.0	1.3	3.1	-0.2	0.2	0.6	-1.5	-1.8	-1.3	-1.3
Age started oral contraceptive pill	0.8	1.0	3.2	0.1	0.1	-0.3	1.1	1.1	1.8	1.0
Diastolic blood pressure, automated reading	1.4	4.3	6.8	1.1	2.1	-2.4	2.6	1.8	2.2	2.1
Ever depressed for a whole week	1.1	1.3	5.0	-1.9	-2.2	0.4	0.1	-0.1	0.6	-0.1
Unable to work because of sickness or disability	0.5	0.6	3.5	-0.4	-0.5	-0.2	0.2	1.9	-0.4	-0.1
Commuting to job workplace: Cycle	0.4	0.5	1.7	-0.6	0.2	-0.3	0.6	1.3	1.1	-0.2
Myopia	3.7	5.4	11.6	-0.9	-1.9	1.9	-2.9	-3.4	-2.7	-1.7
Vascular/heart problems diagnosed by doctor	0.9	2.4	5.2	-1.9	-1.4	-0.2	-1.6	-1.6	-0.9	-2.3
Cholesterol lowering medication	0.5	0.7	2.1	-0.9	-1.4	1.1	-0.5	0.4	0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	4.8	-0.1	-1.2	2.2	-1.9	-1.1	-1.8	0.2
Pain experienced in last month	0.4	0.6	1.5	0.9	0.8	-0.0	0.5	0.7	0.6	1.2
Supplements: Calcium	0.7	0.8	2.2	-1.5	-0.7	-0.6	-0.2	1.4	0.6	-0.2
Basal cell carcinoma (self-reported)	0.5	0.6	2.0	-1.4	-1.2	-0.6	-0.5	-0.1	0.3	0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.3	-1.1	0.5	-0.4	0.9	0.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.1	1.2	0.7	-0.3	1.4	0.8	1.1	1.7
Heart disease (siblings)	0.7	0.9	1.7	0.0	0.8	-1.3	0.9	0.9	1.0	1.1
Alcohol drinker status: Previous	0.4	0.4	1.8	-0.4	0.1	0.0	-0.4	1.4	-0.7	-0.5
Pack years of smoking	1.3	1.9	4.0	-2.0	-1.7	1.4	-1.1	1.7	-0.6	-0.6
Impedance of whole body	3.4	17.4	30.2	-5.3	-5.5	3.1	-4.8	-2.2	-2.9	-4.3
Leg fat mass (left)	0.7	2.6	7.2	2.7	2.2	-0.7	1.6	1.3	-0.1	0.9
Arm predicted mass (left)	1.8	9.1	14.9	3.8	3.9	-2.0	3.2	2.7	1.8	3.2