Hub : Genes

FANCL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0610	0.0220	7.2e-05	0.009	0.029	0.012	0.029	0.020	0.027	0.00015	0.0120	0.00015	0.00150
2	GTEx	Nerve Tibial	0.0692	0.0332	1.2e-03	0.011	NA	0.033	NA	0.040	0.052	NA	0.0021	NA	0.00079
3	GTEx	Thyroid	0.1370	0.0530	1.2e-03	0.008	NA	0.025	NA	0.014	0.070	NA	0.0048	NA	0.02600
4	TCGA	Thyroid Carcinoma	0.0690	0.0310	1.9e-04	0.006	0.035	0.019	NA	0.019	0.074	0.00021	0.0053	NA	0.00560

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	3.3	-0.7	-0.1	-0.6	-1.8
Bipolar Disorder or Schizophrenia	2.2	5.3	12.5	-3.5	0.5	-0.3	-2.9
Depressed Affect (Nagel 2018)	3.5	7.3	19.0	-4.4	2.5	1.1	1.8
Depression (Nagel 2018)	2.0	3.1	5.6	-2.2	0.9	-1.0	-2.4
Intelligence (Savage-Jansen 2018)	0.6	2.0	3.6	-1.9	1.7	0.7	-0.8
Neuroticism (Nagel 2018)	2.1	4.9	12.1	-3.5	1.6	-1.4	-1.7
Schizophrenia (2018)	2.6	5.3	15.7	-4.0	0.8	0.1	-2.2
Schizophrenia vs Biploar Disorder	2.2	2.9	7.0	-2.6	1.5	1.2	0.8
Worry (Nagel 2018)	3.1	6.5	13.4	-2.2	1.0	-2.6	-3.7
Alzheimer’s Disease (in mother)	0.4	0.4	0.9	0.9	0.9	0.1	0.4
Alzheimer’s Disease (in father)	0.4	0.4	0.6	-0.4	0.8	-0.5	-0.7
Alzheimer’s Disease (including proxy)	0.2	0.2	0.5	0.7	0.7	-0.0	-0.0
Crohns Disease (2017)	1.1	2.4	4.2	-1.4	0.8	1.6	2.0
Irritable Bowel Disease (IBD)	0.5	1.1	2.3	-1.5	0.9	0.5	1.0
Ulcerative Colitis (UC)	0.2	0.4	0.9	-0.9	0.8	-0.1	-0.2
Major Depression (MDD)	2.9	3.5	7.8	-2.8	2.3	-0.6	0.5
Reaction Time	2.1	4.0	7.9	0.6	-2.8	-1.1	-2.6
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.9	-1.7	2.2	0.2	-1.0
Breast Cancer	1.6	3.8	13.4	-0.8	0.6	1.0	3.7
Ovarian Cancer	2.1	2.7	4.6	-2.1	1.9	1.3	1.0
Prostate Cancer	1.6	2.2	6.5	-0.4	0.1	-1.5	2.5
Age at First Birth	0.7	1.0	2.7	-0.6	1.6	-0.0	0.9
Bipolar Disorder (2011)	2.0	2.0	3.3	-1.7	0.4	1.2	-1.8
Body Mass Index (BMI) (2010)	1.3	1.7	4.9	-0.2	-0.3	2.2	1.4
Coronary Artery Disease (CAD)	2.1	2.5	4.5	-1.4	2.1	1.8	0.7
Crohns Disease (2012)	0.7	1.2	2.4	-0.2	1.0	1.1	1.6
Mean Putamen Volume	1.0	1.1	3.4	0.7	0.7	-1.8	-0.3
Fasting Glucose	1.2	1.5	4.1	-0.2	0.3	2.0	1.3
HbA1C	0.8	0.9	2.3	0.2	-1.5	1.0	0.3
HDL Cholesterol	1.3	2.2	3.9	2.0	-1.1	-1.9	-0.1
LDL Cholesterol	0.5	0.8	1.0	-1.0	0.8	-0.7	-1.0
Lupus	1.1	1.6	5.2	0.3	-0.1	-2.3	-1.1
Neuroticism (2016)	3.3	4.7	9.9	-3.1	2.2	-1.9	-0.9
Primary Biliary Cirrhosis	1.0	1.4	4.5	-0.6	0.1	2.1	0.9
Rheumatoid Arthritis	0.4	0.6	0.8	0.8	-0.2	-0.9	0.8
Schizophrenia (2014)	3.3	7.3	25.7	-5.1	1.4	-0.2	-1.3
Triglycerides	1.5	2.4	6.4	-2.5	0.9	1.5	-0.2
Type 2 Diabetes (T2D) (2012)	2.9	3.3	5.7	-2.4	1.1	1.3	2.2
Ulcerative Colitis	0.2	0.3	0.8	-0.2	0.9	0.4	0.1
Blood Eosinophil Count	0.3	2.0	4.3	-2.1	1.8	0.5	-0.2
Blood Platelet Count	0.2	1.8	3.3	-0.8	1.8	0.3	1.8
Blood Red Count	0.1	1.1	2.7	1.6	-1.1	-0.6	-0.4
Blood White Count	0.4	3.0	8.4	-1.9	0.3	0.2	2.9
Heel T-Score	0.2	1.9	5.8	-0.3	0.3	1.2	2.4
BMI	1.3	7.8	12.5	-0.5	-3.5	3.5	2.5
Height	0.2	3.5	8.6	-1.7	2.9	-1.3	-0.8
Waist Hip Ratio (WHR)	3.4	15.5	32.1	-4.7	5.7	0.2	2.7
Systolic Blood Pressure	1.3	6.6	9.0	3.0	-2.2	-2.8	-2.2
Smoking Status	0.6	1.4	4.5	0.9	0.1	-2.1	-0.6
Allergy or Eczema	0.2	0.6	1.5	0.6	-1.2	-0.3	-0.7
Cardiovascular Disease	1.1	3.6	8.2	0.3	-2.4	2.9	0.3
Hypothyroidism (self reported)	0.5	1.1	2.4	0.8	0.0	1.1	1.6
Respiratory disease	0.2	0.4	1.5	-0.1	-0.3	-1.2	0.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.1	0.3	-0.4	1.4	1.2
Lung FEV1/FVC ratio	0.1	0.6	1.0	1.0	-0.9	0.8	0.4
Lung FVC	0.9	4.4	11.8	-2.2	3.4	-0.5	-0.8
Neuroticism	3.4	8.2	21.3	-4.6	1.4	-1.6	-2.7
Chronotype (morning person)	1.7	3.9	10.0	0.6	2.2	0.8	3.2
Hair Pigment	0.0	0.2	0.4	-0.2	0.4	0.3	-0.7
Tanning	0.1	1.6	3.7	0.5	1.9	-1.1	1.2
Hand grip strength (left)	0.6	1.5	2.8	1.1	-1.7	-0.6	-1.3
Number of treatments/medications taken	1.3	2.4	5.1	-1.3	-1.5	2.3	-0.8
Average weekly spirits intake	1.0	1.2	2.9	0.2	-0.8	-1.7	-1.0
Sensitivity / hurt feelings	2.6	4.4	9.9	-0.4	0.3	-2.8	-3.1
Frequency of depressed mood in last 2 weeks	1.2	1.6	3.5	-1.7	-0.1	-0.0	-1.9
Hearing difficulty/problems: Yes	1.1	1.7	4.4	-1.5	2.1	0.5	0.1
Relative age of first facial hair	0.3	0.7	1.5	-0.7	0.2	-1.2	-0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.2	-1.5	0.1	0.0	-1.0
Ever used hormone-replacement therapy (HRT)	3.5	4.5	8.3	-2.9	2.4	1.1	1.7
Ever had hysterectomy (womb removed)	1.1	1.3	3.6	-1.9	0.8	-0.2	0.9
Systolic blood pressure, automated reading	1.4	4.1	7.1	2.7	-2.0	-2.0	-1.2
Eye problems/disorders: Diabetes related eye disease	4.4	4.8	14.5	-0.3	-0.2	3.8	2.2
Angina	0.9	1.2	3.3	-1.8	-0.7	1.0	-0.4
Medication for hormone replacement therapy	1.4	1.5	2.2	1.1	-0.9	-1.5	-1.4
Vitamin and mineral supplements	4.5	6.2	14.7	-1.7	3.8	1.1	2.4
Supplements: Zinc	3.8	4.1	8.5	1.2	-1.9	-1.8	-2.9
Medication: Co-codamol	2.0	2.3	4.6	-1.1	1.2	2.1	1.5
Medication: Metformin	0.3	0.4	0.9	-0.6	-0.5	1.0	0.4
Diabetes (father)	0.4	0.5	1.4	-1.2	-0.2	0.6	0.4
Diabetes (mother)	1.3	1.6	3.6	-1.9	0.7	-1.6	0.3
Severe depression (siblings)	2.1	2.4	5.6	-2.4	1.6	0.1	1.2
Pack years adult smoking proportion	0.3	0.5	1.1	-0.2	0.3	1.0	0.8
Impedance of leg (right)	2.9	14.0	30.9	-3.8	5.6	-2.8	1.8
Leg fat-free mass (left)	0.5	2.4	5.0	1.4	-2.2	1.5	0.6
Trunk fat percentage	2.1	8.5	18.2	-2.9	1.3	2.3	4.3
Hand grip strength (right)	0.5	1.3	2.6	1.1	-1.6	-0.4	-1.0
Townsend deprivation index at recruitment	1.5	2.1	4.8	-0.2	-1.8	-0.7	-2.2
Current tobacco smoking	0.1	0.2	0.3	0.5	0.1	-0.6	-0.1
Average weekly fortified wine intake	0.3	0.3	1.0	1.0	-0.4	-0.1	0.2
Maternal smoking around birth	0.4	0.6	1.9	-0.4	1.4	0.1	0.4
Fed-up feelings	1.0	1.7	4.9	-2.2	0.2	1.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.5	-2.1	1.2	-0.4	-0.0
Relative age voice broke	0.7	1.0	1.7	-1.3	0.8	0.2	-1.3
Taking other prescription medications	0.5	0.7	1.8	-1.3	-0.5	0.7	-0.7
Age when periods started (menarche)	1.1	2.7	6.6	-0.3	2.6	-1.8	1.0
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.7	-0.6	-1.7	0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.4	0.7	-0.5	-1.2	-0.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	-0.1	-0.8	0.3	-0.1
Qualifications: CSEs or equivalent	1.5	1.9	7.6	0.1	-2.8	-0.1	0.4
Serious illness, injury or assault to yourself	0.5	0.7	2.1	-1.4	0.4	-0.6	-0.2
High blood pressure	1.4	4.0	8.1	2.9	-2.5	1.4	-0.1
Hayfever, allergic rhinitis or eczema	1.3	2.7	4.9	0.7	-2.2	-0.9	-2.2
Multivitamins +/- minerals	6.7	8.5	14.8	3.3	-3.9	-1.1	-2.7
Stomach or abdominal pain in last month	0.9	1.1	1.7	-1.2	-0.2	-1.1	-1.3
Supplements: Glucosamine	1.1	1.5	2.0	1.3	-0.5	-1.4	-1.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	-0.6	-0.1	0.0	0.5
Medication: Atenolol	2.0	2.5	3.3	1.7	-1.8	1.2	-1.4
Medication: Levothyroxine sodium	0.9	1.6	3.2	1.1	-0.0	1.8	1.3
Sitting height	0.3	2.1	5.2	0.3	2.3	0.2	1.8
Chronic bronchitis/emphysema (father)	0.7	0.8	2.0	-1.4	0.3	0.5	1.0
High blood pressure (mother)	1.0	1.4	2.5	1.3	-1.6	-1.1	0.6
Body mass index (BMI)	1.6	7.0	10.7	-0.7	-2.5	3.2	3.3
Impedance of leg (left)	2.6	12.6	30.8	-3.6	5.5	-1.7	2.0
Leg predicted mass (left)	0.5	2.4	5.0	1.5	-2.2	1.4	0.6
Trunk fat mass	1.5	6.4	14.5	-2.4	0.7	2.2	3.8
Waist circumference	2.6	9.5	20.4	-3.0	1.1	2.6	4.5
Number of incorrect matches in round	1.8	3.0	7.6	-2.8	-0.2	-0.5	-2.0
Past tobacco smoking	1.2	2.1	4.5	0.9	-1.0	2.1	1.5
Alcohol usually taken with meals	0.6	1.0	3.2	-0.5	0.1	1.8	0.7
Nervous feelings	2.4	4.5	13.4	-0.8	0.0	-2.0	-3.7
Frequency of tenseness / restlessness in last 2 weeks	1.9	3.0	5.6	-1.8	0.8	-1.6	-2.4
Hearing difficulty/problems with background noise	4.1	6.5	15.3	-2.7	3.9	-1.8	-0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.1	-0.2	-0.0	-0.2
Had menopause	2.8	3.5	6.1	-0.4	2.4	1.4	2.5
Had other major operations	0.2	0.3	0.6	-0.5	0.8	0.6	-0.1
Forced vital capacity (FVC)	0.3	1.2	3.8	-0.8	2.0	-0.6	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.3	0.6	0.0	-0.1	0.3
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	5.9	-2.4	1.9	-0.1	-0.9
Qualifications: None of the above	0.7	1.5	3.2	-0.8	-0.6	1.3	1.8
Financial difficulties in last 2 years	1.9	2.5	4.9	0.4	-2.1	0.7	-2.2
Mouth/teeth dental problems	1.9	2.9	4.2	-2.1	1.7	-0.1	2.1
Heart attack	0.4	0.5	1.5	-1.2	-0.4	0.3	-0.7
Allergy	0.5	1.2	2.0	0.2	1.3	1.1	1.4
Pain all over the body in last month	0.8	0.8	1.4	-0.1	-1.2	1.0	1.0
Diabetes (self-reported)	0.2	0.3	1.0	-0.2	-0.1	1.0	-0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.6	-1.3	-0.7	0.2	-0.5
Medication: Ramipril	1.7	2.1	5.3	-0.7	-1.6	2.3	0.5
Medication: Simvastatin	1.5	2.2	5.2	-1.5	0.9	2.3	0.6
Fluid intelligence score	1.0	2.1	2.9	-1.7	1.3	1.5	-1.1
Illnesses of siblings	2.9	4.1	10.4	1.3	-0.5	-3.2	-2.0
Neuroticism score	1.9	3.9	10.5	-3.2	0.9	-0.7	-1.9
Weight	0.8	4.0	6.9	-0.5	-1.6	2.5	2.6
Impedance of arm (right)	0.9	4.3	10.2	-0.8	3.2	-2.5	-0.1
Arm fat percentage (right)	1.4	5.4	13.3	-1.5	-1.0	2.3	3.6
Trunk fat-free mass	0.3	1.8	4.1	1.3	-2.0	1.3	0.2
Hip circumference	0.8	3.5	8.2	-1.0	-0.6	2.1	2.9
Time employed in main current job	1.0	1.2	4.4	-0.3	-2.1	0.2	-0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.2	-0.6	-0.4	-0.4
Father’s age at death	0.3	0.4	0.9	0.9	0.1	0.1	0.8
Worrier / anxious feelings	1.8	3.4	4.5	-2.1	0.8	-2.0	-2.1
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.5	21.4	-4.6	1.6	-0.5	-1.3
Falls in the last year	2.2	3.0	6.6	-1.3	2.6	-0.6	1.8
Hair/balding pattern: Pattern 3	0.5	0.7	1.7	0.1	0.3	-1.3	-1.0
Number of live births	2.9	4.1	9.1	-2.0	3.0	1.3	1.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.4	-0.3	1.2	-0.7	0.1
Pulse rate	0.5	0.9	2.1	-0.7	-0.6	0.9	1.5
Happiness	1.5	1.9	2.9	-1.7	0.3	1.7	-1.3
Noisy workplace	0.3	0.3	0.8	0.4	0.5	0.3	0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.8	-1.4	1.9	-0.0	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	-0.5	0.9	-0.4	0.2
Mouth/teeth dental problems: Dentures	1.1	1.8	6.0	1.0	-2.4	0.0	-0.5
Asthma	0.2	0.4	0.8	-0.9	0.0	-0.3	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.0	-1.7	-0.4	0.5	0.7
Medication: Cholesterol lowering	1.5	2.4	5.7	-1.6	0.6	2.4	0.9
Depression (self-reported)	3.6	4.3	8.7	-3.0	2.0	-2.0	-0.8
Medication: Lansoprazole	0.4	0.4	1.0	-0.6	-0.0	1.0	0.6
Prospective memory result	1.1	1.4	2.5	0.5	-1.6	0.3	1.6
Lung cancer (father)	1.2	1.4	4.1	-2.0	1.2	0.3	0.1
Illnesses of mother	0.3	0.3	1.1	-1.0	-0.1	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	-0.3	0.7	-0.4	-0.4
Pulse wave Arterial Stiffness index	1.9	2.2	3.4	-1.5	1.5	0.8	1.9
Impedance of arm (left)	0.9	4.1	11.6	-0.5	3.4	-2.1	-0.1
Arm fat mass (right)	1.5	6.0	13.5	-1.4	-0.9	2.8	3.7
Trunk predicted mass	0.3	1.8	3.8	1.2	-1.9	1.3	0.3
Standing height	0.2	1.8	4.5	0.4	2.1	-1.4	-0.7
Length of working week for main job	5.0	5.6	13.8	3.7	-2.0	-1.9	-0.7
Exposure to tobacco smoke at home	0.1	0.2	0.4	-0.2	0.6	-0.4	-0.2
Breastfed as a baby	0.6	0.7	1.1	-0.8	0.7	1.1	0.8
Tense / ‘highly strung’	2.4	4.0	8.5	-2.3	0.5	-1.4	-2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	4.9	15.5	-3.9	1.5	0.5	-1.1
Hair/balding pattern: Pattern 4	0.5	1.3	2.6	1.1	-1.6	0.6	-0.9
Birth weight of first child	0.4	0.7	1.1	-0.8	-0.2	1.1	1.0
Peak expiratory flow (PEF)	0.7	1.7	2.9	-1.7	1.4	-1.4	-0.2
Pulse wave reflection index	0.6	0.7	2.2	-0.4	1.5	-0.7	0.1
Ever highly irritable/argumentative for 2 days	2.5	2.9	7.3	-2.7	0.9	1.2	1.4
Loud music exposure frequency	0.9	1.0	2.5	-0.9	-0.7	0.3	-1.6
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	7.9	-1.2	2.8	-0.3	-0.1
Mouth/teeth dental problems: Bleeding gums	3.5	4.6	8.9	2.2	-2.1	-0.2	-3.0
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.4	0.2	-0.3	-0.4
Medication: Paracetamol	0.9	1.4	2.9	-1.7	-1.3	1.1	-0.2
Headache pain in last month	0.4	0.7	1.6	-1.2	1.0	-0.3	0.4
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	6.8	1.3	0.8	-2.6	-0.4
Glaucoma (self-reported)	1.9	2.2	6.2	0.4	-1.1	-1.1	-2.5
Gout (self-reported)	0.3	0.4	0.8	0.1	0.9	-0.3	-0.8
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.3	1.5	-1.3	1.2	0.4
Medication: Amlodipine	1.3	1.8	2.8	1.6	-0.5	1.3	1.7
Medication: Ventolin 100micrograms inhaler	2.2	2.8	7.1	-2.7	1.8	-0.5	0.8
Birth weight	0.6	1.3	4.4	0.1	-0.7	-0.2	-2.1
Chronic bronchitis/emphysema (mother)	1.6	1.9	5.1	-0.7	2.3	-1.2	-0.8
High blood pressure (siblings)	2.4	3.5	8.8	-0.9	0.8	3.0	1.9
Forced vital capacity (FVC), Best measure	0.3	1.0	3.0	-0.9	1.7	0.2	-0.4
Body fat percentage	2.0	8.0	18.5	-2.8	0.9	2.2	4.3
Leg fat percentage (right)	1.9	7.0	16.1	-2.9	0.4	1.8	4.0
Arm fat-free mass (right)	0.3	1.7	4.3	0.3	-0.8	2.1	1.4
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.8	0.1	-0.6	-0.4
Comparative body size at age 10	0.5	1.4	3.8	-0.0	-1.9	0.7	-1.2
Number of full brothers	1.8	2.3	4.8	-2.2	-0.1	1.8	-1.0
Worry too long after embarrassment	2.3	3.8	8.7	-0.0	0.3	-2.5	-3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	4.3	5.6	18.3	-4.3	0.4	-0.4	-1.9
Wheeze or whistling in the chest in last year	0.4	0.7	2.0	-1.0	0.2	0.3	1.4
Number of children fathered	0.5	0.5	0.9	0.9	-0.8	-0.8	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	5.0	-0.4	0.5	-2.2	-2.0
Age at first live birth	0.4	0.8	1.6	0.1	-0.0	-1.3	-1.2
Pulse wave peak to peak time	1.6	1.8	3.0	1.5	-1.3	-0.7	-1.7
Health satisfaction	0.1	0.2	0.4	-0.5	0.1	0.6	0.1
Shortness of breath walking on level ground	2.0	2.4	4.9	-2.2	2.1	-0.0	-0.6
Qualifications: College or University degree	1.9	6.1	10.2	0.2	2.3	-3.2	-3.0
Eye problems/disorders: None of the above	0.8	1.0	1.8	1.2	-0.5	-1.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	-0.2	0.0	1.0	-1.0
Emphysema/chronic bronchitis	1.6	1.8	3.6	-1.9	1.4	-0.7	1.1
Medication for pain relief, constipation, heartburn	1.9	3.2	7.2	0.9	2.2	-2.7	0.4
Neck or shoulder pain in last month	0.2	0.2	0.4	-0.6	0.6	-0.4	-0.0
Medication: Blood pressure	0.9	1.6	3.5	-0.6	-1.9	1.1	-1.1
Angina (self-reported)	0.9	1.2	3.0	-1.7	-0.6	1.2	-0.1
Migraine (self-reported)	0.4	0.6	1.8	-0.6	0.4	1.3	-0.1
Medication: Ibuprofen	1.3	1.6	3.6	-1.9	-0.6	1.1	1.0
Medication: Allopurinol	0.8	1.1	2.0	-0.6	1.4	-0.7	-1.2
Medication: Omeprazole	1.1	1.3	2.2	-1.2	-1.2	1.5	-0.3
Medication: Seretide 50 evohaler	2.3	2.6	5.2	-1.8	2.3	-1.2	-0.7
Mean time to correctly identify matches	1.5	2.9	7.8	0.1	-1.9	-0.5	-2.8
Heart disease (mother)	0.3	0.4	0.6	-0.3	0.7	0.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	-0.6	-0.2	1.3	1.2
Whole body fat mass	1.3	5.6	13.8	-2.0	0.1	2.2	3.7
Leg fat mass (right)	1.3	4.9	11.7	-2.0	-0.2	1.9	3.4
Arm predicted mass (right)	0.4	2.0	4.8	0.4	-1.0	2.2	1.4
Pulse rate, automated reading	0.5	1.8	4.4	-1.0	-0.3	1.2	2.1
Alcohol intake frequency.	2.2	5.1	15.8	0.9	-4.0	1.3	-1.5
Comparative height size at age 10	0.2	1.1	3.1	0.3	0.9	-0.4	-1.8
Number of full sisters	2.4	3.0	8.0	-2.8	-0.8	1.8	-0.2
Suffer from ‘nerves’	1.8	2.9	6.8	-0.9	-0.4	-2.0	-2.6
Overall health rating	1.3	2.8	8.5	-2.9	0.0	1.6	-0.1
Chest pain or discomfort	1.8	2.6	4.3	0.1	-2.1	-1.3	-2.1
Had major operations	1.8	2.1	5.6	-2.4	0.7	1.3	0.9
Age at last live birth	0.6	0.9	2.7	0.1	0.6	-0.7	-1.6
Family relationship satisfaction	3.2	4.0	5.9	-1.5	2.4	2.2	1.7
Leg pain on walking	1.8	2.2	6.7	-2.6	-0.8	0.5	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	0.3	-0.4	-0.3	0.6
Commuting to job workplace: Car/motor vehicle	2.2	2.5	5.1	0.0	-0.3	2.2	2.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.8	0.5	1.7	-1.0	1.4
Medication: Aspirin	1.2	1.6	5.7	0.3	-0.7	2.4	-0.3
Supplements: Vitamin C	0.8	1.0	2.5	-0.9	-1.6	-0.2	-0.7
Knee pain experienced in last month	0.2	0.4	1.2	0.1	-0.2	1.1	0.4
Hypertension (Self-reported)	1.0	2.6	5.3	2.3	-1.9	1.4	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-0.7	-1.0	0.6	-0.4
Illnesses of father: Heart disease	1.3	1.8	3.6	0.2	1.9	1.4	1.3
Illnesses of siblings: Diabetes	1.0	1.2	2.3	-1.5	0.3	1.0	1.2
Smoking status: Previous	0.5	0.8	1.7	-0.8	0.5	-1.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.2	1.1	0.1	-0.3	0.5
Whole body fat-free mass	0.4	2.4	4.8	1.4	-2.2	1.6	0.4
Leg fat-free mass (right)	0.7	3.8	6.8	2.1	-2.6	2.0	0.3
Arm fat percentage (left)	1.3	5.4	12.9	-1.3	-0.9	2.5	3.6
Average weekly red wine intake	0.3	0.5	1.3	1.1	0.6	-0.0	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.3	-0.2	-0.6	0.2
Mood swings	2.0	3.6	7.6	-2.7	1.2	1.2	2.0
Loneliness, isolation	0.3	0.5	1.8	-1.3	0.1	0.1	0.2
Long-standing illness, disability or infirmity	3.0	4.6	12.4	-3.5	1.0	2.1	0.7
Ever had bowel cancer screening	0.5	0.6	1.1	-0.9	1.1	0.2	0.8
Diabetes diagnosed by doctor	0.6	1.0	2.8	-1.0	-0.0	1.7	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.7	-0.3	-0.8	-0.0	-1.6
Friendships satisfaction	1.0	1.2	4.0	-0.9	2.0	-0.3	-0.3
Qualifications: nursing, teaching	1.0	1.5	2.9	-1.3	1.7	0.7	0.8
Commuting to job workplace: Walk	2.3	2.5	4.0	-1.2	0.8	-2.0	-2.0
Eye problems/disorders: Cataract	0.9	1.1	2.7	-1.6	0.9	0.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	1.0	-0.7	0.6	-1.2
Medication for cholesterol	0.1	0.2	0.8	-0.1	0.2	-0.9	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	0.4	-1.0	0.4	-0.3
Back pain experienced in last month	0.8	1.2	1.6	-1.2	0.4	1.3	1.2
Mineral and other dietary supplements	3.2	4.4	7.3	-2.7	2.7	0.6	1.6
Breast cancer (self-reported)	0.4	0.5	0.8	0.6	-0.8	-0.1	-0.9
Asthma (self-reported)	0.3	0.5	1.1	-1.0	-0.1	-0.2	1.0
Osteoporosis (self-reported)	1.2	1.5	3.3	-1.4	1.8	-0.8	-0.1
Osteoarthritis (self-reported)	0.8	1.1	2.0	0.9	-1.0	0.6	1.4
Medication: Aspirin	1.5	1.9	5.9	0.2	-1.2	2.4	-0.4
Medication: Gliclazide	1.4	1.6	3.6	0.5	-1.9	-1.2	-1.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.2	0.2	-0.6	-0.2
Smoking status: Current	0.1	0.2	0.4	0.6	0.1	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.5	-1.6	1.3	-0.1	-0.6
Whole body water mass	0.4	2.4	4.2	1.4	-2.0	1.7	0.5
Leg predicted mass (right)	0.7	3.7	6.6	2.1	-2.6	1.9	0.3
Arm fat mass (left)	1.3	5.5	11.8	-1.1	-1.0	2.8	3.4
Number of self-reported non-cancer illnesses	0.5	0.9	1.3	-1.0	-0.8	1.1	-0.9
Average weekly champagne plus white wine intake	0.8	1.2	2.1	-0.2	1.4	-0.7	-1.5
Miserableness	2.8	4.9	11.8	-3.4	2.3	0.9	1.3
Guilty feelings	2.2	3.3	7.5	-2.7	0.2	-0.3	-2.3
Wears glasses or contact lenses	0.8	0.9	2.1	-1.5	1.0	0.6	-0.1
Ever taken oral contraceptive pill	4.3	4.8	10.5	1.5	-0.4	-3.2	-2.5
Hearing aid user	1.4	1.6	3.4	1.1	-0.6	1.2	1.9
Mother’s age at death	0.7	0.9	1.8	1.2	0.7	-0.1	-1.3
Financial situation satisfaction	0.4	0.5	1.2	-0.7	0.0	0.6	-1.1
Tinnitus: Yes, now most or all of the time	2.3	2.7	6.2	0.2	-2.1	-0.5	-2.5
Commuting to job workplace: Public transport	3.1	3.8	9.9	1.5	-0.1	-1.6	-3.2
Eye problems/disorders: Glaucoma	1.8	2.2	3.9	0.8	-1.6	-1.2	-2.0
Medication: Blood pressure	0.9	1.7	3.2	1.0	0.1	1.6	1.8
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.6	-1.6	0.2	0.7	0.8
Supplements: Fish oil (including cod liver oil)	3.7	4.8	9.1	3.0	-3.0	0.3	-1.0
High cholesterol (Self-reported)	2.7	4.8	9.2	-3.0	1.3	2.6	1.3
Medication: Bendroflumethiazide	0.4	0.7	1.7	0.1	0.1	1.3	1.0
Medication: Paracetamol	1.3	2.0	4.2	-2.0	-1.0	1.7	-0.1
Medication: Lisinopril	0.6	0.7	1.3	-0.4	-0.8	1.1	0.9
Medication: Atorvastatin	1.3	1.6	4.5	-2.1	1.2	0.4	-0.2
Illnesses of father: High blood pressure	4.1	5.0	10.5	2.5	-3.2	-0.3	-1.8
Alcohol drinker status: Never	2.2	2.6	5.2	0.9	-2.3	-0.6	-2.0
Ever smoked	2.0	3.6	8.1	-0.2	0.5	-2.4	-2.8
Basal metabolic rate	0.4	2.4	3.8	0.9	-2.0	1.9	1.1
Leg fat percentage (left)	2.3	8.4	17.9	-2.9	0.3	2.7	4.2
Arm fat-free mass (left)	0.4	2.3	5.1	0.2	-1.2	2.3	1.6
Number of operations (self-reported)	1.4	2.1	5.5	-2.4	1.3	1.1	0.3
Average weekly beer plus cider intake	1.8	2.5	7.0	-1.7	0.6	0.0	2.6
Irritability	3.0	5.1	13.7	-3.7	2.3	-0.8	-0.8
Risk taking	1.9	2.8	5.2	-2.3	1.2	2.0	0.9
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.0	-1.0	0.3	1.0	0.7
Fractured/broken bones in last 5 years	1.0	1.4	2.8	-0.5	1.1	1.7	1.1
Age started oral contraceptive pill	1.9	2.3	5.5	-1.2	2.4	-0.9	-1.3
Diastolic blood pressure, automated reading	0.9	2.7	6.7	2.6	-1.5	-1.3	0.4
Ever depressed for a whole week	1.2	1.4	2.6	-1.4	1.6	0.6	-1.0
Unable to work because of sickness or disability	2.0	2.6	4.3	-2.1	1.1	1.7	1.4
Commuting to job workplace: Cycle	1.9	2.3	5.4	-1.2	1.1	-1.1	-2.3
Myopia	1.3	1.9	5.4	-1.0	-0.2	-1.1	-2.3
Vascular/heart problems diagnosed by doctor	1.4	3.9	7.0	-2.5	2.6	-1.5	-0.0
Cholesterol lowering medication	1.7	2.5	4.8	-1.8	1.1	2.2	0.9
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.4	-2.1	-0.4	1.3	-0.6
Pain experienced in last month	0.1	0.2	0.7	0.5	0.9	0.1	0.1
Supplements: Calcium	2.4	2.7	7.0	0.7	-2.6	-0.3	-1.8
Basal cell carcinoma (self-reported)	0.9	1.1	2.5	-0.8	0.9	0.7	1.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.5	-1.2	-0.2	0.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.2	0.1	0.4	-0.2	0.0
Heart disease (siblings)	1.5	1.8	4.6	-1.6	-0.1	2.1	0.3
Alcohol drinker status: Previous	0.5	0.6	1.7	-0.6	-0.5	1.3	-0.0
Pack years of smoking	0.6	0.8	1.2	-0.5	1.1	0.9	1.0
Impedance of whole body	1.7	8.6	24.1	-2.3	4.9	-2.0	1.0
Leg fat mass (left)	1.5	5.9	13.4	-1.9	-0.3	2.5	3.7
Arm predicted mass (left)	0.4	2.1	4.0	0.0	-1.2	2.0	1.7