Hub : Genes

FARP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1030	0.031	0.00012	0.049	0.043	0.048	0.044	0.048	1.2e-06	5.3e-06	1.4e-06	4.2e-06	1.5e-06
2	GTEx	Testis	0.1910	0.075	0.00770	0.168	NA	0.079	NA	0.120	6.3e-08	NA	2.2e-04	NA	5.6e-06
3	NTR	Blood	0.0202	0.008	0.00490	0.008	0.008	0.006	0.008	0.009	9.4e-04	9.0e-04	2.9e-03	8.4e-04	4.3e-04
4	TCGA	Thyroid Carcinoma	0.0960	0.036	0.00210	0.000	0.022	0.038	NA	0.006	3.2e-01	3.1e-03	1.3e-04	NA	8.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.5	5.9	-0.2	0.4	-0.3	-2.4
Bipolar Disorder or Schizophrenia	0.3	0.7	1.5	-0.6	0.8	0.4	-1.2
Depressed Affect (Nagel 2018)	2.7	5.7	13.8	2.9	0.0	-3.7	0.7
Depression (Nagel 2018)	3.5	5.2	13.3	2.7	0.6	-3.6	-0.0
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.1	-2.0	0.2	1.7	-0.2
Neuroticism (Nagel 2018)	3.2	7.6	15.2	3.7	1.1	-3.9	0.2
Schizophrenia (2018)	0.2	0.3	0.5	-0.6	0.7	0.7	0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	0.7	-0.2	0.1	1.3
Worry (Nagel 2018)	3.8	8.1	16.5	4.1	0.7	-3.8	-0.8
Alzheimer’s Disease (in mother)	0.9	1.1	2.6	-1.6	-1.1	0.4	-0.7
Alzheimer’s Disease (in father)	0.6	0.6	2.0	0.6	1.4	0.1	-0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	2.2	-1.5	-0.2	0.5	-0.3
Crohns Disease (2017)	1.7	3.7	6.9	2.1	-1.9	-2.6	-0.2
Irritable Bowel Disease (IBD)	1.5	3.5	7.6	2.3	-1.0	-2.8	-0.6
Ulcerative Colitis (UC)	0.6	1.2	1.9	1.1	-0.0	-1.4	-1.3
Major Depression (MDD)	0.1	0.1	0.3	0.2	-0.3	-0.6	-0.4
Reaction Time	4.3	8.1	13.1	2.8	3.6	-2.2	-2.5
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.1	-1.8	0.6	1.6	-0.3
Breast Cancer	2.5	5.9	10.8	3.3	0.3	-2.9	2.2
Ovarian Cancer	1.0	1.4	4.8	-0.8	-2.2	-0.3	-0.3
Prostate Cancer	0.2	0.3	0.7	0.8	0.5	-0.0	0.5
Age at First Birth	2.5	3.6	7.4	-2.3	-1.2	2.7	-0.1
Bipolar Disorder (2011)	0.6	0.6	1.6	-0.7	0.5	1.2	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	2.7	1.3	-0.8	-1.6	0.6
Coronary Artery Disease (CAD)	1.6	1.9	4.0	-0.6	-1.0	2.0	1.6
Crohns Disease (2012)	1.4	2.3	3.9	1.7	-0.9	-2.0	-1.3
Mean Putamen Volume	3.6	4.1	12.5	-3.5	-0.9	1.8	0.1
Fasting Glucose	0.8	1.0	3.3	0.3	-0.4	-0.5	1.8
HbA1C	1.5	1.7	3.1	1.5	0.1	-1.8	1.2
HDL Cholesterol	0.7	1.1	3.4	-0.7	-0.6	0.6	-1.8
LDL Cholesterol	0.1	0.1	0.1	0.4	0.2	-0.4	-0.2
Lupus	0.8	1.2	3.2	0.8	-0.6	-1.8	-0.9
Neuroticism (2016)	7.5	10.8	23.8	4.9	1.7	-4.1	0.2
Primary Biliary Cirrhosis	0.5	0.7	1.8	0.5	-1.3	-0.3	0.8
Rheumatoid Arthritis	1.5	2.0	3.0	-1.4	-0.8	1.7	-1.6
Schizophrenia (2014)	0.3	0.7	1.2	-1.0	0.7	1.1	-0.1
Triglycerides	0.9	1.5	2.8	0.9	-1.0	-1.3	1.7
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.9	0.2	-0.7	-0.2	1.0
Ulcerative Colitis	0.6	0.9	2.8	-0.2	0.4	-0.7	-1.7
Blood Eosinophil Count	0.5	3.5	6.6	1.2	-2.4	-0.4	2.6
Blood Platelet Count	0.1	1.3	4.3	-0.0	2.1	0.8	-0.4
Blood Red Count	0.2	1.6	3.2	1.6	-0.1	-1.8	0.8
Blood White Count	0.3	2.2	3.1	1.8	-1.2	-1.7	1.1
Heel T-Score	0.4	3.4	6.2	-1.6	-2.2	2.5	0.1
BMI	3.4	19.9	42.9	5.9	-1.4	-6.6	0.6
Height	0.6	12.3	22.4	-4.6	-0.5	4.7	2.4
Waist Hip Ratio (WHR)	0.3	1.2	2.7	0.6	0.4	-1.2	-1.6
Systolic Blood Pressure	0.3	1.3	3.1	1.8	1.4	-0.1	-0.2
Smoking Status	0.2	0.5	1.8	0.3	-1.3	0.0	-0.4
Allergy or Eczema	0.8	2.0	5.9	0.0	0.8	-1.2	-2.4
Cardiovascular Disease	1.2	4.1	8.0	2.8	1.9	-2.1	-0.0
Hypothyroidism (self reported)	0.5	1.1	3.6	0.5	1.9	0.7	-0.3
Respiratory disease	0.2	0.5	1.8	-0.2	1.3	-0.2	0.2
Type 2 Diabetes (T2D) (2018)	2.1	4.0	8.8	3.0	0.1	-2.6	-0.5
Lung FEV1/FVC ratio	0.4	1.8	2.7	1.6	-0.8	-1.6	1.1
Lung FVC	1.6	7.9	15.4	-3.9	-1.0	3.5	-1.8
Neuroticism	4.9	11.8	23.6	4.7	1.0	-4.9	-0.5
Chronotype (morning person)	0.4	0.9	1.9	-0.9	0.6	0.8	-1.4
Hair Pigment	0.0	0.9	1.8	1.4	0.6	-1.1	0.5
Tanning	0.1	0.8	2.4	-1.5	-0.4	0.8	-0.4
Hand grip strength (left)	2.2	5.8	13.8	-3.7	0.4	2.8	-1.2
Number of treatments/medications taken	1.7	3.0	6.4	2.5	0.7	-2.2	-0.4
Average weekly spirits intake	0.3	0.4	1.1	0.5	1.1	-0.5	0.0
Sensitivity / hurt feelings	0.9	1.5	3.0	0.9	1.4	-0.7	-1.7
Frequency of depressed mood in last 2 weeks	5.0	7.0	16.6	3.2	0.7	-4.1	-0.7
Hearing difficulty/problems: Yes	3.1	4.7	12.9	-3.6	-0.8	2.1	-1.0
Relative age of first facial hair	0.2	0.5	1.7	-0.3	1.3	0.5	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.1	-1.0	1.0	-0.0	-1.1
Ever used hormone-replacement therapy (HRT)	1.9	2.5	8.6	1.1	2.9	-0.3	-0.0
Ever had hysterectomy (womb removed)	0.8	0.9	1.6	-0.0	1.3	-1.2	0.8
Systolic blood pressure, automated reading	0.9	2.6	6.4	2.5	1.5	-1.0	-0.9
Eye problems/disorders: Diabetes related eye disease	2.5	2.8	5.2	2.3	0.3	-1.9	-1.5
Angina	0.5	0.7	1.9	0.8	-0.5	-1.4	-0.3
Medication for hormone replacement therapy	1.5	1.6	6.2	-0.0	2.5	-0.2	-0.5
Vitamin and mineral supplements	0.5	0.7	1.4	-1.1	-1.2	0.2	0.5
Supplements: Zinc	1.3	1.5	4.3	-0.9	-0.1	0.8	-2.1
Medication: Co-codamol	3.2	3.8	8.2	2.9	0.7	-1.6	1.9
Medication: Metformin	0.9	1.3	1.8	1.0	-1.4	-0.9	-1.2
Diabetes (father)	0.5	0.6	1.6	0.3	1.3	-0.5	-0.7
Diabetes (mother)	3.7	4.8	11.3	2.5	-0.9	-3.4	0.8
Severe depression (siblings)	0.9	1.1	2.4	1.2	1.5	-0.5	0.1
Pack years adult smoking proportion	1.9	2.9	6.1	2.5	0.6	-2.3	0.0
Impedance of leg (right)	0.3	1.3	4.5	0.8	-0.4	-0.1	2.1
Leg fat-free mass (left)	0.2	0.9	2.5	0.9	-0.5	-1.6	0.0
Trunk fat percentage	5.6	22.5	42.9	6.4	0.1	-6.6	2.3
Hand grip strength (right)	0.8	2.1	5.8	-2.4	-0.2	0.9	-1.4
Townsend deprivation index at recruitment	4.0	5.6	8.2	2.9	-0.9	-2.4	2.8
Current tobacco smoking	0.4	0.7	1.2	1.1	-0.4	-0.8	0.8
Average weekly fortified wine intake	2.8	3.3	6.5	-2.5	-0.5	2.4	-1.0
Maternal smoking around birth	1.4	2.0	3.7	1.8	0.5	-1.9	1.0
Fed-up feelings	2.6	4.7	10.3	2.8	0.5	-3.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	4.8	6.4	15.4	3.1	0.4	-3.9	0.6
Relative age voice broke	1.3	2.0	4.0	-2.0	1.1	1.7	0.4
Taking other prescription medications	1.3	2.0	3.7	1.6	1.9	-1.2	-0.7
Age when periods started (menarche)	0.3	0.6	1.4	-0.7	-0.3	1.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.6	-0.4	0.8	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.6	-0.1	-1.6	1.5	0.4
Tinnitus: Yes, but not now, but have in the past	1.6	1.8	3.9	1.5	-1.0	-2.0	-0.2
Qualifications: CSEs or equivalent	3.4	4.5	6.4	2.5	-0.7	-2.5	2.2
Serious illness, injury or assault to yourself	0.3	0.3	0.6	-0.8	0.5	0.0	-0.6
High blood pressure	1.1	3.2	8.9	3.0	0.3	-1.7	0.9
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.7	-0.3	1.0	-0.9	-1.3
Multivitamins +/- minerals	0.2	0.2	0.6	0.1	0.5	0.1	-0.8
Stomach or abdominal pain in last month	1.7	2.1	4.8	1.8	0.1	-2.2	-0.8
Supplements: Glucosamine	0.5	0.6	1.8	0.4	-0.7	-0.2	-1.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	0.3	-0.9	-0.8	-0.1
Medication: Atenolol	0.5	0.6	1.6	0.7	-0.4	-1.3	-0.2
Medication: Levothyroxine sodium	0.7	1.2	2.2	-0.9	1.3	1.5	-0.3
Sitting height	0.3	2.3	3.8	-2.0	0.1	1.6	1.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.2	-0.1	-0.7	-0.5
High blood pressure (mother)	0.6	0.8	1.4	1.2	0.3	-0.6	1.2
Body mass index (BMI)	3.2	13.6	30.0	4.9	0.0	-5.5	0.9
Impedance of leg (left)	0.2	1.1	3.7	0.8	-0.3	-0.0	1.9
Leg predicted mass (left)	0.2	0.9	2.7	0.9	-0.5	-1.6	-0.0
Trunk fat mass	3.9	16.8	33.5	5.4	-0.1	-5.8	2.0
Waist circumference	2.8	10.4	23.0	4.2	-0.6	-4.8	0.8
Number of incorrect matches in round	0.5	0.9	1.7	1.3	0.5	-0.8	0.9
Past tobacco smoking	0.9	1.7	3.2	1.8	0.8	-1.4	1.1
Alcohol usually taken with meals	3.5	5.7	8.6	-2.8	2.0	2.9	-1.4
Nervous feelings	4.8	9.0	17.7	4.2	1.4	-4.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	5.2	8.0	13.7	3.7	0.2	-3.7	-2.2
Hearing difficulty/problems with background noise	0.7	1.1	2.8	-1.7	-0.2	1.2	-0.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	-0.5	-0.1	0.8	0.5
Had menopause	0.1	0.1	0.1	0.3	0.3	-0.2	0.3
Had other major operations	0.4	0.5	0.8	-0.7	0.3	0.7	-0.9
Forced vital capacity (FVC)	2.3	9.0	17.9	-4.2	-0.1	4.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.7	0.4	-1.1	1.3	1.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-1.1	-0.4	0.7	-0.1
Qualifications: None of the above	2.4	5.2	10.1	3.2	1.5	-2.8	-0.7
Financial difficulties in last 2 years	2.6	3.5	7.5	2.7	0.0	-2.2	1.2
Mouth/teeth dental problems	0.6	0.9	1.8	1.4	0.6	-0.7	-0.9
Heart attack	0.2	0.2	0.5	-0.3	-0.4	0.1	0.7
Allergy	0.3	0.6	1.8	0.2	-1.3	0.3	0.6
Pain all over the body in last month	3.1	3.3	6.0	2.4	0.3	-1.8	1.9
Diabetes (self-reported)	1.2	1.8	3.5	1.9	-1.0	-1.6	-0.4
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	6.5	0.4	0.2	-0.2	-2.5
Medication: Ramipril	0.9	1.1	2.3	1.0	0.7	-0.7	1.5
Medication: Simvastatin	0.9	1.3	2.2	1.1	1.2	-0.7	-1.5
Fluid intelligence score	0.8	1.7	3.6	-1.9	0.8	1.4	-0.8
Illnesses of siblings	1.1	1.6	3.4	-1.8	0.4	1.6	-0.1
Neuroticism score	4.8	10.1	19.8	4.2	1.3	-4.5	-1.3
Weight	1.3	6.3	14.4	3.1	-0.5	-3.8	0.9
Impedance of arm (right)	0.2	0.8	1.4	0.6	-0.9	-0.6	1.2
Arm fat percentage (right)	5.5	21.7	45.8	6.2	-0.2	-6.8	1.6
Trunk fat-free mass	0.2	1.3	3.6	-1.9	-0.6	1.0	-0.5
Hip circumference	1.8	7.6	15.7	3.6	-0.5	-4.0	1.2
Time employed in main current job	0.5	0.6	0.9	0.3	0.7	-0.8	-0.9
Alcohol intake versus 10 years previously	2.5	3.8	9.3	2.0	1.0	-3.1	-0.8
Father’s age at death	1.5	2.0	3.4	-1.5	-1.5	1.8	-0.1
Worrier / anxious feelings	2.9	5.5	10.2	3.0	1.2	-3.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	3.4	5.5	15.1	2.6	0.3	-3.9	-0.1
Falls in the last year	0.7	1.0	1.9	0.3	0.8	1.1	1.4
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	1.0	-0.2	-0.4	-0.7
Number of live births	0.1	0.2	0.5	0.4	0.7	0.1	-0.4
Forced expiratory volume in 1-second (FEV1)	2.0	6.8	14.1	-3.6	-0.4	3.7	0.0
Pulse rate	0.6	1.1	1.9	0.2	-1.0	-1.4	-1.1
Happiness	0.1	0.1	0.1	-0.0	0.3	-0.2	0.3
Noisy workplace	2.0	2.5	4.9	2.2	-0.5	-2.1	-0.6
Qualifications: A levels/AS levels or equivalent	2.7	5.9	14.0	-3.7	0.2	3.1	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	1.3	-0.2	-1.1	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	0.4	-0.7	-1.0	-0.6
Asthma	0.6	1.2	2.3	-0.1	1.5	-0.5	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.2	0.9	-0.5	-0.3	1.5
Medication: Cholesterol lowering	1.1	1.8	4.0	2.0	0.9	-1.5	-0.4
Depression (self-reported)	1.5	1.8	3.9	1.7	0.4	-2.0	-0.6
Medication: Lansoprazole	0.9	1.0	1.4	1.1	-1.2	-1.2	-0.3
Prospective memory result	0.5	0.6	2.2	-0.5	1.5	0.3	0.1
Lung cancer (father)	1.5	1.7	3.8	-0.6	0.7	1.5	2.0
Illnesses of mother	0.6	0.8	1.2	-0.8	0.5	1.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	8.0	16.4	-3.9	-0.8	4.0	-0.1
Pulse wave Arterial Stiffness index	3.4	3.9	7.2	2.5	0.2	-1.5	2.7
Impedance of arm (left)	0.1	0.5	1.6	0.6	0.0	-0.4	1.2
Arm fat mass (right)	3.6	14.8	30.6	5.1	-0.2	-5.5	1.7
Trunk predicted mass	0.2	1.2	3.4	-1.8	-0.5	1.0	-0.4
Standing height	0.6	5.6	12.0	-3.5	-0.8	3.1	0.6
Length of working week for main job	0.6	0.6	2.2	0.4	1.5	-0.1	0.5
Exposure to tobacco smoke at home	0.3	0.3	1.0	0.1	-0.4	-0.3	-1.0
Breastfed as a baby	2.4	2.9	6.8	-2.6	0.1	2.2	0.5
Tense / ‘highly strung’	3.5	5.8	12.8	3.2	0.1	-3.6	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	4.1	6.2	8.8	2.4	1.1	-3.0	-3.0
Hair/balding pattern: Pattern 4	0.6	1.5	3.8	1.9	0.9	-1.1	0.1
Birth weight of first child	0.6	1.1	2.3	-0.8	-1.5	0.9	-0.8
Peak expiratory flow (PEF)	0.2	0.4	0.8	-0.9	-0.7	0.3	0.3
Pulse wave reflection index	2.8	3.5	9.7	1.7	0.5	-1.0	3.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.3	-0.3	-1.5	-0.1	-0.2
Loud music exposure frequency	2.3	2.5	3.4	1.9	-1.0	-1.9	1.5
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	3.2	-1.5	-0.5	1.8	-0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.6	-1.3	0.5	0.5	0.5
Blood clot in the leg (DVT)	0.8	1.0	2.9	1.0	0.2	-0.0	1.7
Medication: Paracetamol	0.7	1.2	2.4	-0.9	-0.5	1.1	1.6
Headache pain in last month	0.6	1.0	3.0	-0.2	1.7	0.9	-0.4
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	5.9	-2.4	0.2	2.3	-1.0
Glaucoma (self-reported)	1.7	2.0	7.2	-0.3	0.6	0.6	2.7
Gout (self-reported)	0.2	0.3	0.6	-0.2	0.8	0.6	-0.4
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	7.7	0.4	2.8	0.5	-0.5
Medication: Amlodipine	0.9	1.2	3.1	1.8	-0.4	-1.2	0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	-0.0	0.3	1.0	0.6
Birth weight	0.2	0.5	1.3	-0.5	0.4	0.5	1.1
Chronic bronchitis/emphysema (mother)	1.5	1.7	3.7	1.9	-0.3	-1.6	0.7
High blood pressure (siblings)	0.4	0.6	1.1	0.6	-1.1	-0.6	0.7
Forced vital capacity (FVC), Best measure	3.1	11.3	23.8	-4.6	-0.4	4.9	-0.4
Body fat percentage	6.2	24.5	47.6	6.7	-0.1	-6.9	2.3
Leg fat percentage (right)	6.5	23.6	46.2	6.5	-0.4	-6.8	2.3
Arm fat-free mass (right)	0.0	0.2	0.5	-0.5	-0.3	0.1	0.7
Exposure to tobacco smoke outside home	0.2	0.2	0.6	0.8	-0.0	-0.5	-0.1
Comparative body size at age 10	0.1	0.2	0.5	-0.1	-0.3	-0.7	0.5
Number of full brothers	1.1	1.4	5.3	0.2	-0.3	-0.2	2.3
Worry too long after embarrassment	2.5	4.2	8.4	2.9	2.0	-2.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	4.4	2.1	0.9	-2.1	-1.7
Wheeze or whistling in the chest in last year	3.8	6.8	12.1	3.5	0.6	-3.5	1.7
Number of children fathered	0.9	1.0	2.0	-1.4	0.2	0.3	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.2	0.1	-1.5	-0.1	-0.1
Age at first live birth	1.4	2.5	4.8	-2.2	-0.8	2.2	0.2
Pulse wave peak to peak time	4.0	4.7	8.1	-2.9	-0.3	1.8	-2.7
Health satisfaction	1.4	1.8	3.6	0.7	1.6	-0.7	1.9
Shortness of breath walking on level ground	0.9	1.1	2.3	1.2	0.7	0.1	1.5
Qualifications: College or University degree	5.0	15.8	31.8	-5.6	-1.4	5.4	0.4
Eye problems/disorders: None of the above	0.4	0.4	1.1	1.0	0.4	-0.6	-0.2
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.0	0.4	-0.5	-0.6	2.0
Emphysema/chronic bronchitis	1.2	1.4	4.3	-0.3	0.9	0.6	-2.1
Medication for pain relief, constipation, heartburn	0.2	0.4	1.2	-0.5	-0.2	0.2	-1.1
Neck or shoulder pain in last month	0.9	1.3	3.8	0.6	0.0	-1.1	2.0
Medication: Blood pressure	2.4	4.2	6.9	2.6	-0.4	-2.5	1.9
Angina (self-reported)	0.3	0.4	1.3	0.4	-0.4	-1.1	-0.1
Migraine (self-reported)	0.6	0.8	2.2	1.5	0.1	0.0	1.0
Medication: Ibuprofen	0.6	0.7	1.3	0.8	-0.9	-0.3	1.1
Medication: Allopurinol	0.2	0.3	0.5	-0.5	-0.5	0.7	0.1
Medication: Omeprazole	0.1	0.1	0.4	0.2	-0.3	-0.6	-0.2
Medication: Seretide 50 evohaler	1.0	1.2	2.8	1.7	-0.3	-1.2	0.6
Mean time to correctly identify matches	4.5	8.5	16.0	2.5	4.0	-2.3	-2.6
Heart disease (mother)	0.7	0.9	1.3	-0.9	1.1	0.5	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.8	5.7	13.4	2.8	1.0	-3.7	0.8
Whole body fat mass	4.2	17.5	33.6	5.7	-0.3	-5.8	2.0
Leg fat mass (right)	4.3	16.9	33.3	5.5	-0.6	-5.8	1.9
Arm predicted mass (right)	0.1	0.3	0.4	-0.6	-0.4	0.4	0.7
Pulse rate, automated reading	0.9	3.0	7.4	1.5	-1.3	-2.7	-0.7
Alcohol intake frequency.	2.6	6.1	10.2	2.7	1.6	-3.2	-2.0
Comparative height size at age 10	0.6	3.5	7.0	-2.6	-0.4	2.5	-0.5
Number of full sisters	0.5	0.6	1.1	1.0	0.2	-1.0	0.7
Suffer from ‘nerves’	2.7	4.2	8.5	2.9	0.9	-2.7	0.5
Overall health rating	3.0	6.3	14.7	3.1	-0.2	-3.8	0.9
Chest pain or discomfort	0.7	1.0	2.3	-0.0	-1.4	0.0	1.5
Had major operations	2.2	2.6	4.6	-2.2	0.1	1.1	-2.1
Age at last live birth	1.0	1.5	2.2	-1.5	0.0	1.3	-1.5
Family relationship satisfaction	0.5	0.6	1.0	-1.0	0.7	0.8	0.3
Leg pain on walking	0.4	0.5	0.8	0.9	0.6	-0.7	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	4.4	2.1	0.0	-2.1	0.6
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.9	0.6	0.3	-1.1	-2.0
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	5.1	-2.1	0.5	2.3	-0.1
Medication: Aspirin	1.0	1.3	3.3	0.9	0.5	-0.9	-1.8
Supplements: Vitamin C	1.3	1.5	2.7	1.4	1.6	-0.9	-0.7
Knee pain experienced in last month	0.2	0.4	0.8	0.2	0.9	0.2	-0.8
Hypertension (Self-reported)	0.8	2.3	6.3	2.5	0.1	-1.5	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	-0.1	0.3	-0.2	-0.3
Illnesses of father: Heart disease	0.3	0.4	1.0	0.2	-0.6	-1.0	0.3
Illnesses of siblings: Diabetes	0.8	0.9	1.4	1.1	-0.3	-1.2	1.0
Smoking status: Previous	0.8	1.2	1.9	-1.4	-1.2	1.0	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	5.4	-2.3	-0.4	1.1	-1.7
Whole body fat-free mass	0.0	0.2	0.4	-0.6	-0.5	-0.1	-0.2
Leg fat-free mass (right)	0.1	0.3	1.0	0.3	-0.3	-1.0	-0.2
Arm fat percentage (left)	5.3	21.0	43.2	6.2	-0.1	-6.6	1.6
Average weekly red wine intake	1.0	1.5	4.0	-1.3	-0.1	2.0	0.1
Handedness (chirality/laterality): Left-handed	1.3	1.6	5.1	-0.7	-0.4	0.7	2.3
Mood swings	6.2	11.3	23.0	4.1	2.1	-4.8	-0.8
Loneliness, isolation	0.7	1.0	2.2	1.2	0.0	-1.5	0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.9	0.1	-1.0	-0.5	0.2
Ever had bowel cancer screening	1.1	1.3	2.9	-1.0	-0.3	1.7	1.1
Diabetes diagnosed by doctor	1.0	1.7	4.3	2.1	-0.3	-1.5	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.9	-0.5	1.4	1.1	0.1
Friendships satisfaction	1.7	2.1	4.2	-2.0	1.4	1.3	0.8
Qualifications: nursing, teaching	6.6	10.3	23.8	-4.9	-0.7	4.1	-0.6
Commuting to job workplace: Walk	1.7	1.9	3.3	1.8	0.8	-1.0	1.6
Eye problems/disorders: Cataract	2.0	2.3	5.0	-2.2	-1.2	1.6	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.2	0.7	1.0	0.1	1.1
Medication for cholesterol	1.0	1.5	5.1	-0.5	-2.3	-0.0	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	3.9	0.7	2.0	0.2	0.7
Back pain experienced in last month	0.7	1.0	2.5	0.8	1.6	-1.0	0.1
Mineral and other dietary supplements	1.5	2.1	6.9	-0.3	-1.1	-0.2	2.6
Breast cancer (self-reported)	2.4	2.8	8.0	-0.3	1.8	-0.1	-2.8
Asthma (self-reported)	0.6	1.2	2.9	0.1	1.4	-0.5	1.7
Osteoporosis (self-reported)	0.2	0.2	0.5	0.7	-0.0	-0.6	-0.1
Osteoarthritis (self-reported)	0.1	0.1	0.4	-0.2	0.1	0.2	-0.7
Medication: Aspirin	1.5	2.0	3.7	0.9	1.5	-1.1	-1.9
Medication: Gliclazide	1.3	1.5	5.7	0.5	-2.4	0.1	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.4	0.1	-0.2	0.2
Smoking status: Current	0.3	0.5	1.0	1.0	-0.6	-0.6	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	3.9	7.2	-2.6	-1.4	2.7	-0.1
Whole body water mass	0.0	0.2	0.5	-0.7	-0.6	0.0	-0.2
Leg predicted mass (right)	0.0	0.2	0.7	0.2	-0.4	-0.9	-0.1
Arm fat mass (left)	3.5	14.2	30.2	5.0	0.2	-5.5	1.3
Number of self-reported non-cancer illnesses	0.7	1.3	3.3	1.8	-0.1	-1.3	0.4
Average weekly champagne plus white wine intake	2.2	3.1	5.1	-1.9	-2.3	1.9	-0.3
Miserableness	2.6	4.4	12.9	2.2	-0.4	-3.6	0.3
Guilty feelings	1.2	1.7	3.1	1.8	1.2	-1.4	-0.8
Wears glasses or contact lenses	0.2	0.3	0.7	0.4	-0.3	0.3	0.8
Ever taken oral contraceptive pill	0.9	1.0	1.9	-0.2	-1.1	-1.4	0.9
Hearing aid user	0.6	0.7	2.4	0.2	-1.5	-0.1	0.6
Mother’s age at death	0.4	0.6	1.6	-0.8	-1.2	0.1	-0.2
Financial situation satisfaction	2.5	3.1	6.4	1.7	1.1	-1.4	2.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.3	-0.2	1.5	0.0	0.8
Commuting to job workplace: Public transport	1.0	1.2	2.5	0.5	-1.6	-1.3	-0.5
Eye problems/disorders: Glaucoma	1.3	1.6	6.0	-0.0	0.5	0.3	2.4
Medication: Blood pressure	0.5	1.0	2.3	1.5	1.1	-0.2	0.6
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.2	1.1	-0.5	-0.8	-1.1
Supplements: Fish oil (including cod liver oil)	1.9	2.5	9.2	0.9	0.3	-0.4	-3.0
High cholesterol (Self-reported)	1.0	1.7	2.9	0.8	1.7	-0.8	-1.7
Medication: Bendroflumethiazide	0.7	1.1	1.8	1.3	0.2	-1.0	1.3
Medication: Paracetamol	0.7	1.1	1.4	-1.1	-0.7	1.1	1.2
Medication: Lisinopril	1.9	2.5	4.9	2.2	-0.8	-1.8	1.1
Medication: Atorvastatin	1.3	1.6	2.6	1.4	1.1	-1.6	-0.9
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.6	0.3	0.6	-0.1
Alcohol drinker status: Never	0.7	0.8	1.8	0.6	0.5	-0.9	-1.4
Ever smoked	0.6	1.1	2.1	-1.4	0.2	1.4	-0.5
Basal metabolic rate	0.1	0.4	1.2	0.3	-0.5	-1.1	0.2
Leg fat percentage (left)	6.0	21.8	43.4	6.3	-0.4	-6.6	2.1
Arm fat-free mass (left)	0.0	0.2	0.3	-0.2	-0.5	-0.3	0.6
Number of operations (self-reported)	2.4	3.5	5.2	-2.3	1.7	1.5	-2.0
Average weekly beer plus cider intake	0.6	0.9	1.2	0.8	-1.1	-0.9	1.1
Irritability	1.9	3.2	6.3	1.8	1.4	-2.5	-1.2
Risk taking	1.3	1.9	3.8	-1.7	0.4	2.0	0.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.2	-1.1	-0.1	1.0	-1.1
Fractured/broken bones in last 5 years	1.1	1.5	2.0	-1.4	-0.8	1.4	-1.2
Age started oral contraceptive pill	0.1	0.2	0.3	0.1	0.4	0.4	0.5
Diastolic blood pressure, automated reading	0.8	2.6	5.1	2.3	-1.1	-1.9	0.6
Ever depressed for a whole week	0.7	0.8	2.3	-0.5	-0.8	0.2	-1.5
Unable to work because of sickness or disability	2.3	3.0	5.8	2.4	1.5	-2.0	-0.2
Commuting to job workplace: Cycle	2.6	3.1	5.4	-2.3	-1.2	2.1	1.1
Myopia	1.7	2.4	6.7	2.6	0.2	-1.4	1.0
Vascular/heart problems diagnosed by doctor	1.1	3.1	7.8	-2.8	-0.0	1.9	-1.0
Cholesterol lowering medication	0.8	1.2	2.6	-0.9	0.9	0.7	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.8	0.1	0.1	-0.7	-0.9
Pain experienced in last month	0.6	1.0	1.4	-0.9	-0.9	1.1	1.2
Supplements: Calcium	1.4	1.6	2.1	1.0	1.2	-1.3	-1.4
Basal cell carcinoma (self-reported)	1.6	1.9	4.9	-1.0	2.2	0.9	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	-0.3	-0.4	0.0	1.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.9	0.9	0.4	-0.1	1.7
Heart disease (siblings)	1.9	2.3	3.7	1.8	0.3	-1.5	1.9
Alcohol drinker status: Previous	0.6	0.7	1.6	0.0	0.9	-0.6	-1.3
Pack years of smoking	1.9	2.8	6.1	2.5	0.6	-2.2	-0.2
Impedance of whole body	0.2	1.2	4.1	0.7	0.1	-0.1	2.0
Leg fat mass (left)	3.9	15.2	30.3	5.2	-0.6	-5.5	1.8
Arm predicted mass (left)	0.0	0.2	0.5	-0.1	-0.1	-0.3	0.7