Hub : Genes

FAU

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0780 0.036 0.00620 -0.003 NA -0.001 NA 0.001 7.7e-01 NA 0.43000 NA 0.24000
2 GTEx Small Intestine Terminal Ileum 0.2710 0.099 0.00250 0.056 NA 0.134 NA 0.122 2.3e-02 NA 0.00069 NA 0.00110
3 YFS Blood 0.0241 0.010 0.00058 0.012 0.008 0.005 0.008 0.009 4.6e-05 0.001 0.00830 0.00075 0.00055

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.5 1.5 0.3 -0.0 -1.2
Bipolar Disorder or Schizophrenia 0.8 2.0 3.6 1.9 0.6 -1.4
Depressed Affect (Nagel 2018) 0.2 0.5 1.1 1.1 0.5 -0.2
Depression (Nagel 2018) 0.1 0.2 0.2 -0.4 -0.2 -0.5
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.9 0.5 1.4 0.8
Neuroticism (Nagel 2018) 0.4 0.9 2.3 0.6 -0.2 -1.5
Schizophrenia (2018) 1.0 2.0 4.6 2.2 0.8 -0.9
Schizophrenia vs Biploar Disorder 0.4 0.6 1.3 1.1 -0.5 -0.4
Worry (Nagel 2018) 0.9 2.0 4.7 0.8 -0.8 -2.2
Alzheimer’s Disease (in mother) 0.7 0.8 2.0 -0.2 0.5 1.4
Alzheimer’s Disease (in father) 0.1 0.1 0.3 -0.2 -0.3 -0.5
Alzheimer’s Disease (including proxy) 0.5 0.7 1.3 0.7 0.7 1.1
Crohns Disease (2017) 0.2 0.4 0.9 0.0 -1.0 -0.5
Irritable Bowel Disease (IBD) 0.6 1.5 3.0 0.7 -1.1 -1.7
Ulcerative Colitis (UC) 0.8 1.5 3.8 0.8 -0.3 -2.0
Major Depression (MDD) 1.6 2.0 3.3 -0.6 -1.5 -1.8
Reaction Time 0.6 1.2 3.4 1.8 -0.1 0.4
Verbal and Numeric Reasoning (VNR) 0.5 1.3 1.8 1.1 1.4 0.9
Breast Cancer 2.1 5.0 9.4 -2.2 0.8 3.1
Ovarian Cancer 0.6 0.8 1.7 -1.3 -0.4 -0.8
Prostate Cancer 0.7 0.9 1.5 1.2 1.1 0.0
Age at First Birth 1.6 2.4 5.0 0.9 -1.1 -2.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.1 1.5 3.3 1.8 0.4 -0.9
Coronary Artery Disease (CAD) 2.2 2.6 6.6 -2.6 -0.5 -1.0
Crohns Disease (2012) 0.6 0.9 2.2 -0.3 -1.5 -0.7
Mean Putamen Volume 1.2 1.4 2.6 1.6 1.1 0.6
Fasting Glucose 2.2 2.7 4.6 2.1 1.8 0.3
HbA1C 0.3 0.4 0.9 0.9 0.0 -0.4
HDL Cholesterol 2.2 3.7 6.6 -2.6 -1.6 -1.3
LDL Cholesterol 1.7 2.8 7.5 2.7 0.8 -0.2
Lupus 1.0 1.6 2.0 1.4 1.4 0.9
Neuroticism (2016) 0.3 0.4 0.7 0.1 0.9 -0.6
Primary Biliary Cirrhosis 0.7 1.0 1.6 1.2 0.4 -1.1
Rheumatoid Arthritis 1.2 1.7 3.6 -0.7 -1.0 -1.9
Schizophrenia (2014) 1.2 2.6 4.9 2.2 0.6 -1.6
Triglycerides 0.6 0.9 2.2 1.5 0.7 0.1
Type 2 Diabetes (T2D) (2012) 2.8 3.3 6.4 2.5 1.8 0.6
Ulcerative Colitis 1.1 1.6 4.4 0.5 0.3 -2.1
Blood Eosinophil Count 0.9 6.9 16.2 -4.0 0.3 2.1
Blood Platelet Count 3.2 37.0 108.2 -10.4 -1.0 1.3
Blood Red Count 2.4 23.6 33.8 5.8 4.9 3.5
Blood White Count 0.3 2.6 6.2 -0.8 0.9 2.5
Heel T-Score 0.5 3.9 6.0 2.4 -0.2 -2.4
BMI 0.4 2.5 6.2 0.7 2.5 0.8
Height 1.3 25.9 34.3 -5.9 -5.4 -3.8
Waist Hip Ratio (WHR) 0.9 4.0 8.3 2.9 0.0 -2.0
Systolic Blood Pressure 1.4 6.9 9.3 2.1 3.0 2.6
Smoking Status 0.6 1.5 1.7 1.2 -1.2 -1.3
Allergy or Eczema 0.3 0.7 2.0 -1.4 -0.1 -0.4
Cardiovascular Disease 3.9 12.8 16.8 3.1 4.1 3.5
Hypothyroidism (self reported) 0.1 0.3 0.7 -0.8 0.1 -0.3
Respiratory disease 0.2 0.4 0.8 0.3 -0.9 -0.6
Type 2 Diabetes (T2D) (2018) 3.5 6.5 9.6 3.1 2.5 1.9
Lung FEV1/FVC ratio 0.3 1.7 3.1 0.6 1.2 1.8
Lung FVC 0.9 4.8 11.0 1.2 -1.4 -3.3
Neuroticism 0.3 0.6 1.4 0.7 0.2 -1.2
Chronotype (morning person) 1.0 2.2 4.2 -1.6 -2.0 -0.1
Hair Pigment 0.6 17.2 29.3 -5.4 -4.7 -0.4
Tanning 0.0 0.3 0.8 0.1 0.0 -0.9
Hand grip strength (left) 0.2 0.4 0.7 -0.8 0.8 0.3
Number of treatments/medications taken 1.0 1.8 5.0 -0.1 0.6 2.2
Average weekly spirits intake 0.8 1.0 2.5 -0.6 0.5 1.6
Sensitivity / hurt feelings 0.7 1.2 2.5 -1.6 -0.9 -0.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.2 -0.2 1.1 0.2
Hearing difficulty/problems: Yes 0.2 0.2 0.4 0.0 0.6 0.6
Relative age of first facial hair 0.7 1.4 2.0 -1.4 1.4 0.6
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.3 0.5 0.7 1.1
Ever used hormone-replacement therapy (HRT) 1.5 1.9 3.5 -1.3 -0.8 -1.9
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 -0.5 0.5 0.1
Systolic blood pressure, automated reading 1.1 3.3 5.3 0.8 2.0 2.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.5 0.3 0.0
Angina 0.4 0.5 1.1 1.0 -0.4 -0.4
Medication for hormone replacement therapy 0.2 0.2 0.6 -0.3 -0.8 -0.2
Vitamin and mineral supplements 0.9 1.3 2.9 0.7 -0.7 -1.7
Supplements: Zinc 0.9 1.0 2.3 0.5 0.7 1.5
Medication: Co-codamol 0.9 1.0 2.5 1.6 0.2 0.8
Medication: Metformin 2.0 2.8 6.1 2.5 1.1 1.1
Diabetes (father) 1.4 1.8 2.9 1.7 1.3 0.8
Diabetes (mother) 4.3 5.5 5.9 2.3 2.3 2.4
Severe depression (siblings) 0.6 0.7 1.0 -0.9 -0.5 -1.0
Pack years adult smoking proportion 0.4 0.6 1.5 1.2 0.5 -0.2
Impedance of leg (right) 0.8 3.9 6.1 -1.2 -2.5 -2.0
Leg fat-free mass (left) 0.2 1.1 1.8 -1.3 1.1 0.5
Trunk fat percentage 0.6 2.5 4.2 -0.5 1.8 2.0
Hand grip strength (right) 0.2 0.5 0.8 0.2 0.9 0.8
Townsend deprivation index at recruitment 0.6 0.8 1.8 1.3 0.8 -0.3
Current tobacco smoking 1.8 2.9 6.6 0.6 -1.4 -2.6
Average weekly fortified wine intake 0.5 0.6 1.7 -1.3 0.2 0.1
Maternal smoking around birth 0.2 0.2 0.4 -0.6 0.1 0.6
Fed-up feelings 1.1 2.0 2.9 1.7 1.1 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 0.7 0.9 0.8 -0.2
Relative age voice broke 0.7 1.1 2.1 -0.6 1.4 0.9
Taking other prescription medications 0.2 0.4 0.9 -0.0 -0.5 1.0
Age when periods started (menarche) 1.3 3.1 8.2 -2.9 -1.1 -0.2
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 1.7 1.3 0.9 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.6 1.4 1.2 0.5 -0.0
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.5 0.4 -1.2 -1.0
Qualifications: CSEs or equivalent 0.1 0.1 0.4 0.1 -0.6 0.1
Serious illness, injury or assault to yourself 0.0 0.1 0.2 -0.0 0.1 -0.4
High blood pressure 2.9 8.2 12.0 1.6 3.5 3.2
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.3 -0.5 0.2 0.2
Multivitamins +/- minerals 0.6 0.8 1.8 -0.6 0.6 1.3
Stomach or abdominal pain in last month 0.2 0.3 0.5 0.4 -0.7 -0.4
Supplements: Glucosamine 0.1 0.1 0.2 -0.2 -0.4 0.1
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 3.1 -0.3 1.8 1.5
Medication: Atenolol 1.1 1.4 2.7 -1.6 0.2 1.2
Medication: Levothyroxine sodium 0.3 0.5 1.1 0.0 -0.7 -1.1
Sitting height 0.1 0.8 2.1 0.3 -0.3 -1.5
Chronic bronchitis/emphysema (father) 0.2 0.2 0.4 0.6 0.1 -0.6
High blood pressure (mother) 0.2 0.3 0.6 0.4 -0.6 0.8
Body mass index (BMI) 1.0 4.2 8.6 0.7 2.9 1.9
Impedance of leg (left) 0.7 3.3 5.8 -0.8 -2.4 -1.8
Leg predicted mass (left) 0.2 1.1 2.0 -1.4 1.1 0.4
Trunk fat mass 0.5 1.9 3.0 -0.7 1.7 1.5
Waist circumference 0.5 1.7 4.1 0.6 2.0 0.9
Number of incorrect matches in round 1.8 3.0 7.0 -2.6 0.5 1.3
Past tobacco smoking 0.5 0.9 2.6 -1.6 -0.2 0.1
Alcohol usually taken with meals 1.5 2.4 3.7 -0.8 -1.9 -1.7
Nervous feelings 0.3 0.6 1.2 0.3 -0.7 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.3 -0.1 -0.1 -0.5
Hearing difficulty/problems with background noise 0.5 0.8 2.1 0.3 1.5 -0.4
Hair/balding pattern: Pattern 2 0.6 0.8 0.8 -0.9 -0.9 -0.9
Had menopause 4.6 5.8 10.1 -3.2 -1.2 -2.4
Had other major operations 0.2 0.2 0.4 -0.6 -0.2 -0.4
Forced vital capacity (FVC) 0.5 1.9 3.6 0.6 -1.3 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.6 0.8 -0.1 0.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.2 0.5 0.5 0.4
Qualifications: None of the above 0.1 0.3 0.4 0.6 -0.6 -0.3
Financial difficulties in last 2 years 1.2 1.6 2.8 0.9 1.7 1.1
Mouth/teeth dental problems 2.9 4.4 11.7 -3.4 -0.8 1.0
Heart attack 2.4 3.0 8.7 3.0 0.4 -0.5
Allergy 0.1 0.2 0.3 0.5 0.5 -0.0
Pain all over the body in last month 2.2 2.3 4.0 1.0 2.0 1.4
Diabetes (self-reported) 2.7 4.2 5.9 1.7 1.9 2.4
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 0.9 0.8 -0.7 -0.9
Medication: Ramipril 2.9 3.8 6.3 0.6 2.5 2.1
Medication: Simvastatin 2.4 3.6 6.3 2.5 0.7 2.0
Fluid intelligence score 0.5 1.1 1.8 0.8 1.3 0.9
Illnesses of siblings 0.5 0.7 1.5 0.3 0.6 -1.2
Neuroticism score 0.3 0.6 1.1 0.8 1.1 0.1
Weight 0.2 1.0 2.2 -0.9 1.5 0.4
Impedance of arm (right) 0.2 1.1 1.8 -1.2 -1.4 0.2
Arm fat percentage (right) 1.2 4.7 8.4 0.7 2.9 2.3
Trunk fat-free mass 0.4 2.1 3.7 -1.6 -0.2 -1.9
Hip circumference 0.8 3.5 3.9 -1.6 2.0 2.0
Time employed in main current job 1.1 1.3 2.4 -0.6 -1.0 -1.6
Alcohol intake versus 10 years previously 1.5 2.3 3.2 0.9 1.8 1.7
Father’s age at death 0.6 0.9 2.2 -1.5 -0.5 -0.2
Worrier / anxious feelings 0.1 0.2 0.3 0.0 0.5 -0.6
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.3 9.9 0.8 3.2 1.5
Falls in the last year 0.6 0.8 2.4 -1.6 -0.1 0.2
Hair/balding pattern: Pattern 3 0.8 1.1 2.8 1.7 0.6 0.4
Number of live births 0.4 0.5 0.9 -1.0 -0.1 -0.8
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.2 0.5 -0.9 -1.1
Pulse rate 1.9 3.3 7.7 -1.3 0.7 2.8
Happiness 0.6 0.7 1.1 0.9 -0.5 -1.1
Noisy workplace 0.6 0.7 1.7 -1.3 0.6 0.3
Qualifications: A levels/AS levels or equivalent 0.4 1.0 2.4 0.2 1.5 0.7
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.8 0.2 1.7 1.3
Mouth/teeth dental problems: Dentures 0.7 1.2 1.9 1.4 -0.6 -1.2
Asthma 0.1 0.2 0.5 0.7 0.0 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.8 -0.9 -0.1 0.6
Medication: Cholesterol lowering 3.2 4.9 6.2 2.5 1.8 2.3
Depression (self-reported) 2.0 2.4 3.1 -1.8 -1.2 -1.6
Medication: Lansoprazole 0.3 0.3 0.8 0.9 0.3 0.3
Prospective memory result 1.7 2.1 5.4 -2.3 -0.7 -0.5
Lung cancer (father) 2.2 2.6 4.8 -0.2 -2.2 -1.7
Illnesses of mother 0.8 1.0 2.4 -0.6 0.4 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 2.0 0.2 -1.2 -1.4
Pulse wave Arterial Stiffness index 3.1 3.6 7.9 1.0 1.4 2.8
Impedance of arm (left) 0.3 1.6 2.7 -1.6 -1.3 0.5
Arm fat mass (right) 0.9 3.8 8.5 0.3 2.9 1.7
Trunk predicted mass 0.4 2.3 4.1 -1.7 -0.2 -2.0
Standing height 0.9 9.4 11.2 -3.4 -2.7 -3.1
Length of working week for main job 0.7 0.7 1.1 1.1 0.8 0.7
Exposure to tobacco smoke at home 0.3 0.4 0.8 0.3 0.9 0.5
Breastfed as a baby 0.9 1.1 2.1 -1.4 -0.9 -0.7
Tense / ‘highly strung’ 0.0 0.0 0.1 0.2 -0.3 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.5 5.2 -0.3 -2.3 -1.4
Hair/balding pattern: Pattern 4 0.6 1.5 4.0 -2.0 0.1 0.6
Birth weight of first child 0.2 0.5 0.7 0.8 0.5 0.7
Peak expiratory flow (PEF) 0.2 0.4 1.0 0.3 -1.0 -0.5
Pulse wave reflection index 1.5 1.8 4.5 2.1 1.0 0.1
Ever highly irritable/argumentative for 2 days 0.4 0.5 0.8 0.9 -0.4 0.6
Loud music exposure frequency 1.3 1.4 2.8 -0.0 1.7 1.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.0 -0.6 0.4 -1.0
Mouth/teeth dental problems: Bleeding gums 3.5 4.5 9.5 3.1 1.7 1.1
Blood clot in the leg (DVT) 1.0 1.3 2.9 -0.9 -1.7 -0.5
Medication: Paracetamol 1.2 2.0 4.9 -1.1 0.2 2.2
Headache pain in last month 0.6 1.1 1.6 -1.1 1.3 0.5
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 2.5 -1.1 -1.0 -1.6
Glaucoma (self-reported) 1.4 1.7 5.0 -2.2 -0.1 0.1
Gout (self-reported) 1.0 1.4 3.6 0.0 0.7 1.9
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 0.9 -0.5 -0.6 -1.0
Medication: Amlodipine 1.0 1.4 2.8 -0.7 1.7 1.0
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.3 -0.6 -1.1 -0.6
Birth weight 3.2 7.0 13.6 -1.2 -2.5 -3.7
Chronic bronchitis/emphysema (mother) 1.5 1.7 4.7 0.2 -0.7 2.2
High blood pressure (siblings) 0.5 0.7 1.8 0.4 0.2 1.3
Forced vital capacity (FVC), Best measure 0.7 2.5 4.9 0.7 -1.4 -2.2
Body fat percentage 0.7 2.7 4.0 -0.1 2.0 2.0
Leg fat percentage (right) 0.5 1.8 3.9 -0.2 2.0 1.2
Arm fat-free mass (right) 0.3 1.4 2.7 -1.6 0.1 -1.2
Exposure to tobacco smoke outside home 1.8 2.4 4.0 -0.3 2.0 1.7
Comparative body size at age 10 0.5 1.5 2.8 1.7 1.0 0.9
Number of full brothers 1.4 1.8 2.8 -0.5 -1.7 -1.5
Worry too long after embarrassment 0.5 0.8 1.4 1.0 1.2 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 3.5 4.5 5.4 -1.8 -2.3 -2.2
Wheeze or whistling in the chest in last year 0.0 0.0 0.1 -0.3 -0.0 -0.1
Number of children fathered 0.7 0.7 1.7 1.3 -0.7 0.0
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 5.9 0.6 -0.4 2.4
Age at first live birth 0.9 1.6 2.7 -1.5 0.1 -1.6
Pulse wave peak to peak time 3.7 4.4 9.3 -1.2 -1.5 -3.1
Health satisfaction 0.8 1.0 2.2 0.5 0.8 1.5
Shortness of breath walking on level ground 0.4 0.5 0.9 -0.0 1.0 0.8
Qualifications: College or University degree 0.1 0.3 0.4 -0.5 0.6 -0.6
Eye problems/disorders: None of the above 0.0 0.0 0.0 -0.1 0.1 0.0
Mouth/teeth dental problems: Loose teeth 1.6 1.9 4.2 2.0 -0.1 -1.2
Emphysema/chronic bronchitis 0.0 0.1 0.1 0.2 -0.3 0.0
Medication for pain relief, constipation, heartburn 0.8 1.4 4.1 0.2 -0.1 -2.0
Neck or shoulder pain in last month 0.5 0.7 1.2 1.0 -1.1 0.3
Medication: Blood pressure 1.2 2.0 5.0 -0.3 1.0 2.2
Angina (self-reported) 0.4 0.5 1.6 1.2 -0.0 -0.1
Migraine (self-reported) 0.1 0.1 0.3 0.2 -0.3 -0.5
Medication: Ibuprofen 0.6 0.7 1.3 -1.1 0.1 0.9
Medication: Allopurinol 1.6 2.1 6.1 -0.1 0.6 2.5
Medication: Omeprazole 0.1 0.1 0.4 0.6 -0.1 -0.1
Medication: Seretide 50 evohaler 0.5 0.6 1.2 -1.1 -0.8 0.0
Mean time to correctly identify matches 0.6 1.1 2.2 1.5 -0.7 -0.7
Heart disease (mother) 0.2 0.3 0.7 0.2 0.2 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.0 1.0 0.4 0.5
Whole body fat mass 0.5 2.0 3.8 -0.5 1.9 1.4
Leg fat mass (right) 0.4 1.7 3.7 -0.4 1.9 1.2
Arm predicted mass (right) 0.3 1.3 2.8 -1.7 0.2 -1.0
Pulse rate, automated reading 1.2 3.8 5.3 -2.3 1.1 2.3
Alcohol intake frequency. 0.4 0.9 1.8 0.3 0.9 1.3
Comparative height size at age 10 2.1 11.5 12.5 -3.4 -3.2 -3.5
Number of full sisters 0.6 0.8 1.5 -1.2 0.6 -0.6
Suffer from ‘nerves’ 0.7 1.1 2.0 1.1 -0.4 -1.4
Overall health rating 1.9 4.1 4.2 2.0 2.1 2.1
Chest pain or discomfort 0.0 0.0 0.1 0.2 0.1 -0.2
Had major operations 0.8 1.0 1.9 1.0 1.4 0.3
Age at last live birth 0.3 0.5 1.1 -0.5 0.2 -1.0
Family relationship satisfaction 0.5 0.7 1.1 0.9 1.1 0.1
Leg pain on walking 1.9 2.4 3.4 1.9 1.6 1.2
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.1 -1.1 0.4 1.0
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 -0.6 -0.1 -0.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.6 -0.3 -0.7 -0.7
Medication: Aspirin 0.9 1.2 1.7 1.3 0.4 1.2
Supplements: Vitamin C 0.5 0.6 1.2 -0.1 -0.8 1.1
Knee pain experienced in last month 1.2 1.9 3.8 0.5 1.3 1.9
Hypertension (Self-reported) 2.5 6.9 10.5 1.2 3.2 3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.8 1.6 1.3 0.7 0.5
Illnesses of father: Heart disease 0.0 0.0 0.0 -0.2 -0.1 0.1
Illnesses of siblings: Diabetes 1.9 2.3 5.8 0.8 0.8 2.4
Smoking status: Previous 1.4 2.1 3.3 1.8 1.3 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.6 0.6 0.8 -0.2
Whole body fat-free mass 0.2 1.3 2.7 -1.6 0.2 -1.1
Leg fat-free mass (right) 0.2 0.8 1.2 -1.1 1.1 0.4
Arm fat percentage (left) 1.2 4.7 8.2 0.4 2.9 2.4
Average weekly red wine intake 2.3 3.4 8.1 0.7 -1.3 -2.8
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.3 0.6 0.0 -0.4
Mood swings 0.3 0.5 1.2 0.5 1.1 0.0
Loneliness, isolation 1.1 1.5 2.7 1.3 1.7 0.1
Long-standing illness, disability or infirmity 0.5 0.7 1.6 0.4 1.3 0.7
Ever had bowel cancer screening 0.2 0.2 0.5 0.3 -0.7 -0.1
Diabetes diagnosed by doctor 2.5 4.0 5.3 2.3 2.3 1.3
Ever had stillbirth, spontaneous miscarriage or termination 2.7 2.9 3.9 -1.2 -1.8 -2.0
Friendships satisfaction 0.4 0.5 1.0 1.0 -0.7 -0.2
Qualifications: nursing, teaching 0.3 0.4 1.0 -1.0 0.5 -0.3
Commuting to job workplace: Walk 0.4 0.5 0.7 -0.6 0.6 0.8
Eye problems/disorders: Cataract 0.2 0.3 0.6 0.3 0.3 0.8
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 1.0 1.0 1.0 0.4
Medication for cholesterol 2.6 3.9 5.1 -1.7 -1.9 -2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.8 -0.1 -0.5 1.7
Back pain experienced in last month 1.1 1.6 3.5 0.3 1.9 1.2
Mineral and other dietary supplements 0.4 0.5 0.8 0.8 0.3 -0.9
Breast cancer (self-reported) 2.9 3.5 8.9 -3.0 -1.3 0.1
Asthma (self-reported) 0.0 0.1 0.3 0.1 0.1 0.5
Osteoporosis (self-reported) 2.3 2.9 5.2 -2.3 0.7 1.7
Osteoarthritis (self-reported) 0.6 0.8 1.8 -0.7 0.1 1.4
Medication: Aspirin 0.6 0.8 1.4 0.7 0.6 1.2
Medication: Gliclazide 0.8 0.9 1.7 -0.2 1.3 1.0
Illnesses of father: None of the above (group 1) 0.4 0.5 0.8 -0.7 0.1 0.9
Smoking status: Current 2.1 3.4 7.3 0.6 -1.6 -2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 0.9 0.9 0.8 0.2
Whole body water mass 0.2 1.3 2.7 -1.6 0.3 -1.1
Leg predicted mass (right) 0.2 0.9 1.3 -1.1 1.1 0.5
Arm fat mass (left) 0.7 2.9 6.4 -0.2 2.5 1.5
Number of self-reported non-cancer illnesses 0.3 0.4 1.0 0.5 0.3 1.0
Average weekly champagne plus white wine intake 1.9 2.6 5.0 -2.2 -1.7 -0.2
Miserableness 0.9 1.5 1.8 1.3 1.0 1.3
Guilty feelings 0.1 0.2 0.4 0.0 0.6 -0.3
Wears glasses or contact lenses 1.2 1.4 1.6 -1.2 -1.0 -1.3
Ever taken oral contraceptive pill 0.9 1.0 2.1 0.8 1.5 0.6
Hearing aid user 0.7 0.7 2.1 -1.4 -0.1 0.4
Mother’s age at death 0.8 1.0 1.7 -0.8 -1.3 -0.7
Financial situation satisfaction 0.0 0.0 0.1 0.0 0.1 -0.3
Tinnitus: Yes, now most or all of the time 1.6 1.8 2.8 -1.0 1.3 1.7
Commuting to job workplace: Public transport 0.9 1.1 1.3 1.1 0.8 1.1
Eye problems/disorders: Glaucoma 0.7 0.8 2.3 -1.5 -0.3 -0.4
Medication: Blood pressure 3.2 6.2 8.1 1.7 2.7 2.8
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.6 -0.4 -0.7 -0.2
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.1 -0.8 0.1 1.0
High cholesterol (Self-reported) 1.8 3.2 6.5 2.5 1.1 1.3
Medication: Bendroflumethiazide 0.8 1.2 3.5 -0.0 0.4 1.9
Medication: Paracetamol 1.1 1.7 4.1 -0.7 0.7 2.0
Medication: Lisinopril 0.3 0.4 0.6 -0.7 -0.0 0.8
Medication: Atorvastatin 2.0 2.5 5.8 0.4 2.4 1.3
Illnesses of father: High blood pressure 1.3 1.6 3.0 -0.8 1.1 1.7
Alcohol drinker status: Never 0.1 0.1 0.3 0.2 -0.1 0.6
Ever smoked 0.5 0.8 1.5 1.0 0.0 -1.2
Basal metabolic rate 0.2 0.9 1.7 -1.3 0.7 -0.6
Leg fat percentage (left) 0.6 2.1 4.5 -0.0 2.1 1.4
Arm fat-free mass (left) 0.3 1.3 2.0 -1.4 0.4 -1.3
Number of operations (self-reported) 0.2 0.3 0.7 0.8 -0.1 -0.3
Average weekly beer plus cider intake 0.5 0.7 1.7 1.3 0.5 -0.2
Irritability 0.4 0.7 1.2 -0.9 -1.1 -0.2
Risk taking 0.2 0.3 0.6 0.1 0.5 -0.8
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.0 1.0 -0.5 -0.1
Fractured/broken bones in last 5 years 3.1 4.1 11.7 -3.4 -0.6 -0.3
Age started oral contraceptive pill 0.5 0.6 1.2 -1.1 0.2 -0.8
Diastolic blood pressure, automated reading 2.2 7.0 12.2 0.9 2.8 3.5
Ever depressed for a whole week 0.6 0.8 1.2 1.1 1.0 0.3
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.2 -0.0 -0.5
Commuting to job workplace: Cycle 0.6 0.8 1.6 0.0 -1.3 0.8
Myopia 1.5 2.1 2.9 0.9 1.7 1.7
Vascular/heart problems diagnosed by doctor 2.5 6.8 9.1 -1.8 -3.0 -2.9
Cholesterol lowering medication 1.5 2.2 3.8 1.9 0.9 1.4
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.2 -0.0 -1.1 -0.7
Pain experienced in last month 1.2 2.0 3.1 -1.0 -1.4 -1.8
Supplements: Calcium 1.0 1.2 1.8 -1.4 -0.5 1.2
Basal cell carcinoma (self-reported) 0.2 0.2 0.6 0.3 0.8 0.3
Heart attack/myocardial infarction (self-reported) 2.1 2.7 7.5 2.7 0.2 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 2.8 -0.7 -1.7 -0.2
Heart disease (siblings) 0.0 0.0 0.1 -0.0 -0.3 -0.1
Alcohol drinker status: Previous 2.1 2.4 4.4 0.3 2.1 1.7
Pack years of smoking 0.3 0.5 1.3 1.2 0.2 -0.2
Impedance of whole body 0.3 1.8 3.8 -1.0 -2.0 -0.7
Leg fat mass (left) 0.4 1.7 3.6 -0.4 1.9 1.2
Arm predicted mass (left) 0.3 1.4 2.3 -1.4 0.1 -1.5