Hub : Genes

FBP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.0770	0.0330	2.1e-03	-0.001	NA	0.031	NA	0.009	3.4e-01	NA	9.7e-03	NA	1.1e-01
2	GTEx	Colon Transverse	0.3130	0.1060	6.2e-04	0.036	NA	0.019	NA	0.044	8.1e-03	NA	3.9e-02	NA	3.6e-03
3	YFS	Blood	0.1816	0.0370	0.0e+00	0.141	0.118	0.135	0.143	0.140	1.0e-43	1.4e-36	9.6e-42	2.4e-44	1.6e-43
4	TCGA	Brain Lower Grade Glioma	0.0534	0.0216	1.1e-05	0.018	0.044	0.028	NA	0.020	3.2e-03	8.8e-06	3.1e-04	NA	2.2e-03
5	TCGA	Prostate Adenocarcinoma	0.0344	0.0191	6.7e-03	0.013	0.024	0.001	NA	0.015	1.6e-02	1.2e-03	2.7e-01	NA	1.0e-02
6	TCGA	Thyroid Carcinoma	0.0470	0.0240	4.0e-03	-0.003	0.013	0.004	NA	-0.001	8.1e-01	1.8e-02	1.3e-01	NA	4.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.2	0.8	-0.5	0.1	0.6	0.1	0.2	-0.9
Bipolar Disorder or Schizophrenia	0.2	0.6	2.0	-0.7	0.2	0.5	0.7	-1.4	-0.4
Depressed Affect (Nagel 2018)	1.6	3.4	9.2	1.6	0.9	1.5	-2.3	-3.0	0.1
Depression (Nagel 2018)	0.6	0.9	2.4	1.3	-0.5	-0.2	-0.0	-1.5	1.1
Intelligence (Savage-Jansen 2018)	0.0	0.2	0.4	-0.5	0.5	0.2	0.6	0.1	0.0
Neuroticism (Nagel 2018)	1.7	4.1	11.0	2.2	-0.5	1.6	-2.4	-3.3	0.4
Schizophrenia (2018)	0.4	0.8	4.0	-0.5	0.2	0.2	0.8	-2.0	0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	0.5	0.6	-0.7	-0.3	-0.5	1.2
Worry (Nagel 2018)	1.2	2.5	5.3	1.8	0.1	1.5	-2.3	-2.1	-0.0
Alzheimer’s Disease (in mother)	0.5	0.5	1.3	0.3	0.2	1.1	-0.7	-1.1	-0.3
Alzheimer’s Disease (in father)	0.5	0.6	1.4	1.2	1.0	-0.2	-0.7	-0.6	0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	1.6	0.3	0.8	1.3	-1.2	-0.9	-0.8
Crohns Disease (2017)	0.0	0.1	0.3	-0.5	0.1	-0.1	-0.2	-0.2	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.6	0.1	0.3	0.7	-0.2	0.5
Ulcerative Colitis (UC)	0.2	0.3	0.9	-0.2	-0.4	0.7	0.6	-0.9	0.3
Major Depression (MDD)	1.9	2.3	3.6	1.9	-1.8	-1.9	-0.8	-0.1	1.6
Reaction Time	0.9	1.8	5.9	-0.4	0.1	0.7	-1.7	1.2	-2.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.5	-0.8	0.5	-1.2	0.9	1.1	-0.5
Breast Cancer	0.1	0.3	0.7	-0.5	-0.7	0.8	0.1	-0.5	-0.3
Ovarian Cancer	1.5	2.0	5.8	1.3	0.4	1.8	-1.0	-2.4	0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.4	2.1	5.4	-2.3	-0.5	0.1	1.1	0.5	-2.3
Bipolar Disorder (2011)	0.4	0.4	1.1	-0.8	-0.2	-0.1	0.3	0.6	-1.1
Body Mass Index (BMI) (2010)	0.3	0.5	1.6	0.4	0.4	-1.3	0.2	-0.2	0.9
Coronary Artery Disease (CAD)	0.6	0.7	2.3	-0.4	-1.1	-0.5	0.1	1.5	-0.5
Crohns Disease (2012)	0.1	0.1	0.3	0.2	-0.1	0.2	-0.5	-0.3	0.3
Mean Putamen Volume	0.3	0.4	1.0	-0.1	0.2	-1.0	0.4	0.7	0.5
Fasting Glucose	0.4	0.5	1.6	-0.5	-1.3	-0.9	0.3	-0.5	-0.1
HbA1C	0.9	1.0	3.6	1.2	0.3	-0.3	-0.8	-1.9	0.7
HDL Cholesterol	0.4	0.6	2.4	-0.1	-0.3	0.4	0.9	-1.5	0.7
LDL Cholesterol	0.2	0.4	0.9	-0.5	0.3	-0.9	1.0	-0.2	0.2
Lupus	0.5	0.7	3.2	-0.6	0.6	1.8	0.4	0.2	0.5
Neuroticism (2016)	0.9	1.3	3.5	1.9	0.3	-1.1	-0.8	-0.2	1.5
Primary Biliary Cirrhosis	0.7	1.0	2.5	-0.6	0.4	-0.7	1.5	-1.6	0.7
Rheumatoid Arthritis	0.2	0.3	0.9	0.4	-0.5	-0.9	-0.4	0.3	0.1
Schizophrenia (2014)	0.2	0.4	0.9	-1.0	0.4	0.1	0.6	-1.0	-0.5
Triglycerides	0.1	0.2	0.8	-0.3	0.5	0.1	-0.1	0.9	-0.1
Type 2 Diabetes (T2D) (2012)	1.8	2.0	4.7	1.7	-1.0	-2.2	-1.5	-0.8	0.9
Ulcerative Colitis	0.4	0.6	2.2	-0.8	-0.2	1.5	0.6	0.3	-0.3
Blood Eosinophil Count	0.5	3.6	7.2	1.6	-2.4	-2.7	0.8	-0.6	2.2
Blood Platelet Count	0.1	1.1	4.3	0.5	-0.5	-0.7	-2.1	0.2	-1.1
Blood Red Count	0.6	5.9	17.3	0.8	-0.9	-4.2	3.0	0.9	2.6
Blood White Count	0.2	1.8	3.2	-0.0	-1.7	-1.8	1.7	-0.4	1.4
Heel T-Score	2.6	20.3	61.2	7.8	-0.9	-4.0	-4.2	-0.2	5.2
BMI	0.4	2.1	5.7	2.1	-0.6	-1.0	-2.4	-0.3	1.1
Height	0.9	16.7	53.4	-3.2	-3.6	1.1	-4.2	-2.1	-7.3
Waist Hip Ratio (WHR)	0.2	0.8	2.1	1.4	-0.1	-0.3	-0.8	-1.0	0.8
Systolic Blood Pressure	0.6	2.8	7.0	-0.2	-2.6	-2.1	0.9	2.1	0.7
Smoking Status	0.9	2.1	6.8	-2.2	0.5	0.4	2.6	0.5	0.1
Allergy or Eczema	0.9	2.3	6.6	2.6	-0.0	-0.5	-0.9	-1.9	1.7
Cardiovascular Disease	0.4	1.2	5.1	0.4	-2.3	-1.0	-0.3	0.9	0.0
Hypothyroidism (self reported)	0.5	1.1	2.1	-0.5	-0.8	0.7	-1.4	1.0	-1.4
Respiratory disease	2.1	4.7	11.3	3.4	-1.3	-1.3	-1.1	-1.2	3.3
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.6	0.4	-1.0	-1.3	-0.7	-0.1	0.4
Lung FEV1/FVC ratio	0.5	2.7	8.3	-0.7	1.3	-1.6	2.9	-0.3	1.7
Lung FVC	0.1	0.5	2.0	-1.4	0.4	-0.3	0.1	-0.1	-0.7
Neuroticism	1.6	3.9	10.4	2.6	-0.2	1.1	-1.9	-3.2	1.1
Chronotype (morning person)	0.4	1.0	3.2	0.8	-1.2	0.0	-1.8	0.1	-0.7
Hair Pigment	0.0	1.0	2.4	-1.0	0.3	1.6	0.8	-1.0	-0.8
Tanning	0.1	1.6	3.6	-1.6	-0.3	-0.7	1.9	1.4	-1.0
Hand grip strength (left)	0.2	0.5	1.5	0.1	0.1	-0.9	-0.8	-1.2	-0.2
Number of treatments/medications taken	0.8	1.4	3.3	0.4	-1.8	-1.2	1.0	-0.3	1.6
Average weekly spirits intake	0.3	0.4	1.5	0.1	-1.2	0.2	0.6	-0.4	0.7
Sensitivity / hurt feelings	1.9	3.2	7.8	2.8	-0.7	-0.1	-1.7	-2.5	1.4
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.7	1.5	-0.4	0.1	-1.2	-1.9	0.9
Hearing difficulty/problems: Yes	0.4	0.7	2.3	0.3	-0.5	-1.5	0.2	1.1	0.4
Relative age of first facial hair	1.0	2.0	5.4	-2.3	-0.8	-0.2	0.2	0.7	-2.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.3	-0.5	1.2	-0.3	-1.1	0.2	-1.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.7	1.3	0.9	0.6	-1.0	-1.0	0.7
Ever had hysterectomy (womb removed)	2.6	3.0	8.4	2.1	-0.6	0.7	-0.2	-2.9	2.0
Systolic blood pressure, automated reading	0.4	1.3	3.8	0.5	-1.9	-1.3	-0.5	1.2	0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.4	0.7	-1.2	-0.6	-0.1	-0.9	0.4
Angina	1.2	1.6	4.0	1.6	-0.8	-0.7	0.1	-2.0	1.4
Medication for hormone replacement therapy	1.0	1.1	2.7	-1.6	1.0	0.1	1.1	1.2	-0.6
Vitamin and mineral supplements	1.1	1.5	5.7	-0.1	-2.4	-1.0	-0.1	1.1	-0.9
Supplements: Zinc	0.3	0.3	1.1	-0.5	1.1	0.8	-0.0	0.1	-0.2
Medication: Co-codamol	0.5	0.6	1.5	0.6	0.2	-1.0	0.1	-0.7	1.2
Medication: Metformin	0.2	0.3	0.6	0.3	-0.8	-0.6	-0.7	-0.7	0.1
Diabetes (father)	0.9	1.1	2.1	1.5	-0.0	1.0	-1.3	-1.2	0.2
Diabetes (mother)	0.5	0.6	2.2	-0.2	-1.1	-1.5	0.2	0.4	0.3
Severe depression (siblings)	0.4	0.4	1.6	0.4	-0.4	1.3	0.0	-0.2	0.8
Pack years adult smoking proportion	0.4	0.7	1.7	1.3	0.9	0.9	-0.1	-0.1	0.9
Impedance of leg (right)	0.3	1.5	7.0	-1.1	0.1	-0.8	2.6	-0.4	0.3
Leg fat-free mass (left)	0.8	4.2	18.7	1.1	-0.4	0.2	-4.3	-1.4	-1.7
Trunk fat percentage	0.7	2.8	5.5	2.3	-2.0	-0.7	-2.0	-1.2	1.1
Hand grip strength (right)	0.2	0.7	2.2	0.5	-0.3	-0.6	-1.0	-1.5	0.3
Townsend deprivation index at recruitment	0.6	0.8	3.2	0.5	1.8	0.8	-0.1	-0.6	0.5
Current tobacco smoking	0.5	0.9	1.8	-1.1	0.7	0.8	1.1	1.3	-0.2
Average weekly fortified wine intake	0.8	0.9	3.0	-0.9	0.3	1.7	0.3	-0.4	-1.2
Maternal smoking around birth	0.6	0.8	2.1	-0.7	-1.4	0.3	0.8	1.3	-0.1
Fed-up feelings	1.1	2.0	4.2	2.1	-0.9	-0.6	-0.9	-1.8	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.4	1.4	-1.5	-0.4	0.4	-1.0	1.5
Relative age voice broke	1.1	1.7	4.8	-2.2	0.9	0.7	1.7	0.6	-1.0
Taking other prescription medications	1.0	1.5	2.7	1.6	-1.1	-0.8	-1.2	-1.2	1.2
Age when periods started (menarche)	0.3	0.8	1.6	-0.2	-0.9	1.2	0.3	-0.9	1.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.1	1.6	-0.7	-0.2	-0.5	-0.6	1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	11.4	3.4	-1.2	-1.0	-1.7	-0.9	1.7
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	4.7	-0.5	0.3	-1.1	-1.0	2.2	-1.2
Qualifications: CSEs or equivalent	1.1	1.5	3.8	1.4	1.1	1.3	-0.0	0.2	1.9
Serious illness, injury or assault to yourself	1.1	1.3	3.5	0.6	-1.4	0.9	-0.9	-1.9	-0.1
High blood pressure	0.5	1.4	4.4	1.0	-2.1	-1.1	-1.2	0.2	0.2
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.3	1.8	-0.2	-0.1	0.1	-1.5	1.6
Multivitamins +/- minerals	2.1	2.7	12.2	0.3	3.5	1.0	0.2	-1.1	1.3
Stomach or abdominal pain in last month	0.3	0.4	1.2	0.5	-0.9	1.1	-0.2	-0.3	0.1
Supplements: Glucosamine	1.1	1.5	5.0	-1.2	1.5	-0.1	2.2	0.3	0.0
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.8	1.3	-2.0	0.1	0.1	0.4	1.0
Medication: Atenolol	0.6	0.8	2.4	-0.0	-1.6	0.4	0.8	-1.2	0.3
Medication: Levothyroxine sodium	0.5	0.8	2.3	-0.4	-0.4	0.2	-1.5	0.9	-1.1
Sitting height	0.8	5.9	17.1	-1.5	-1.9	-0.0	-3.2	-1.6	-4.1
Chronic bronchitis/emphysema (father)	1.5	1.7	3.4	1.8	-1.7	-0.9	-0.8	-1.1	1.3
High blood pressure (mother)	0.4	0.5	1.7	-1.0	0.6	-0.0	-0.1	-0.4	-1.3
Body mass index (BMI)	1.0	4.1	10.0	3.1	-0.8	-0.3	-3.2	-1.2	1.6
Impedance of leg (left)	0.3	1.4	5.8	-1.4	-0.3	-0.7	2.4	-0.0	-0.3
Leg predicted mass (left)	0.8	4.3	19.5	1.1	-0.3	0.2	-4.4	-1.4	-1.8
Trunk fat mass	0.7	3.2	9.0	2.0	-1.8	-0.2	-3.0	-1.7	0.1
Waist circumference	1.3	4.9	13.3	3.0	-1.4	-0.5	-3.6	-1.9	0.8
Number of incorrect matches in round	0.3	0.5	1.4	0.3	-0.9	0.3	-0.6	1.2	0.3
Past tobacco smoking	0.1	0.2	0.6	0.8	-0.4	-0.0	-0.5	0.3	-0.4
Alcohol usually taken with meals	0.4	0.7	1.7	-0.0	-1.3	-0.5	0.7	-1.3	0.3
Nervous feelings	0.4	0.7	1.9	1.4	-0.3	-0.1	-1.0	-1.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	5.1	0.7	0.7	1.6	-1.0	-2.3	0.4
Hearing difficulty/problems with background noise	0.9	1.4	2.8	1.7	-1.3	-1.4	-0.6	0.2	1.3
Hair/balding pattern: Pattern 2	0.6	0.8	2.5	0.1	-0.6	1.6	-1.1	0.7	-0.6
Had menopause	0.2	0.2	0.8	0.2	-0.6	-0.4	-0.3	0.9	-0.0
Had other major operations	0.6	0.7	1.0	0.9	-1.0	-0.8	-0.8	-0.4	1.0
Forced vital capacity (FVC)	0.7	2.5	6.8	-2.5	0.8	0.4	-0.3	-1.1	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.1	16.3	4.0	-0.9	-0.9	-2.7	-1.5	1.7
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.2	0.9	-0.3	-1.6	0.6	-0.6	1.8
Qualifications: None of the above	0.4	0.8	1.9	1.2	-1.4	-0.2	-0.6	-0.7	0.7
Financial difficulties in last 2 years	1.0	1.3	2.6	0.8	1.0	1.6	0.3	-1.5	1.1
Mouth/teeth dental problems	1.8	2.8	7.0	0.7	1.0	-2.7	-1.7	2.2	-0.7
Heart attack	0.3	0.3	0.8	0.2	-0.5	-0.4	0.5	-0.9	0.6
Allergy	1.1	2.5	6.8	-2.6	1.2	0.2	0.9	1.4	-1.9
Pain all over the body in last month	0.6	0.6	1.1	1.0	0.6	-0.2	0.8	-1.0	0.7
Diabetes (self-reported)	0.9	1.4	3.3	1.3	-1.5	-0.9	-1.8	-0.6	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.8	0.2	-1.7	-0.1	0.5	0.9	0.1
Medication: Ramipril	0.4	0.5	1.0	1.0	-1.0	0.2	-0.6	0.3	0.6
Medication: Simvastatin	1.2	1.8	6.7	0.8	-1.0	-2.6	0.3	1.0	1.1
Fluid intelligence score	0.6	1.3	3.0	-1.7	1.5	0.1	1.3	0.2	-0.9
Illnesses of siblings	1.3	1.9	4.6	1.5	0.0	-1.0	0.9	-1.6	2.1
Neuroticism score	1.7	3.5	11.5	2.1	-0.1	0.8	-1.8	-3.4	1.1
Weight	0.9	4.6	18.5	2.0	-1.2	-0.5	-4.3	-1.7	-0.6
Impedance of arm (right)	0.2	0.9	4.4	-0.2	-0.1	-0.8	2.1	-0.1	0.6
Arm fat percentage (right)	0.8	3.1	7.7	2.8	-1.0	-0.2	-2.3	-1.5	1.5
Trunk fat-free mass	1.0	5.7	17.8	-0.6	-0.3	0.9	-4.2	-1.6	-3.5
Hip circumference	0.8	3.5	13.1	2.0	-1.5	-0.0	-3.6	-1.3	-0.3
Time employed in main current job	1.2	1.4	3.0	0.0	-0.7	-0.4	1.7	1.3	1.7
Alcohol intake versus 10 years previously	0.4	0.7	2.1	0.9	1.5	0.3	-0.9	0.1	0.3
Father’s age at death	0.7	0.9	4.4	0.3	-0.8	-0.2	0.6	-2.1	0.5
Worrier / anxious feelings	1.0	1.9	5.5	1.1	0.8	1.3	-2.3	-1.7	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.6	1.6	-0.2	-0.8	-1.1	-1.2	1.0
Falls in the last year	1.0	1.3	3.2	1.2	-1.3	0.8	-0.6	-1.8	0.8
Hair/balding pattern: Pattern 3	0.2	0.2	0.4	-0.5	0.6	0.4	0.6	0.4	0.4
Number of live births	0.9	1.3	5.5	1.3	-0.2	-0.2	-2.4	-0.5	0.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	8.5	-2.9	1.4	-0.0	0.4	-0.8	-2.4
Pulse rate	0.7	1.2	5.4	0.3	-2.3	1.0	-0.5	-0.7	0.3
Happiness	1.3	1.6	4.8	1.0	-1.6	0.8	-0.5	-2.2	0.8
Noisy workplace	0.8	1.0	2.2	1.5	-0.9	1.2	-1.1	-0.5	0.6
Qualifications: A levels/AS levels or equivalent	2.2	4.8	14.2	-3.8	0.4	-1.1	2.2	1.8	-2.2
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	5.6	-2.4	-0.5	1.8	1.3	-1.0	-2.0
Mouth/teeth dental problems: Dentures	0.4	0.7	3.1	-0.2	0.6	1.8	0.3	-1.0	0.1
Asthma	1.3	2.5	5.4	2.3	-1.3	-1.5	-0.4	-0.8	2.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.9	0.3	1.5	1.6	-0.0	-1.7	0.3
Medication: Cholesterol lowering	0.9	1.4	3.2	0.9	-1.8	-1.5	-0.9	1.1	0.4
Depression (self-reported)	0.6	0.7	1.6	0.6	1.3	-0.4	-1.3	-0.6	0.1
Medication: Lansoprazole	1.5	1.8	4.8	2.2	0.2	-0.8	-1.2	-1.0	1.6
Prospective memory result	1.4	1.7	3.4	1.3	-0.6	1.8	-1.5	-1.6	-0.2
Lung cancer (father)	0.8	0.9	2.5	1.6	-0.7	0.1	-0.2	-0.6	1.4
Illnesses of mother	0.8	1.0	1.7	-1.1	1.0	1.3	1.2	0.7	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	8.2	-2.9	1.3	0.1	1.2	-1.0	-2.1
Pulse wave Arterial Stiffness index	1.8	2.1	5.3	1.7	-0.5	1.8	-2.3	-0.9	-0.2
Impedance of arm (left)	0.2	1.0	4.3	-0.3	-0.7	-0.9	2.1	0.1	0.3
Arm fat mass (right)	0.9	3.9	12.5	2.7	-0.9	-0.2	-3.5	-1.5	0.6
Trunk predicted mass	1.0	5.8	18.3	-0.5	-0.2	1.0	-4.3	-1.6	-3.5
Standing height	0.8	7.7	28.7	-2.6	-1.1	-0.3	-2.8	-1.3	-5.4
Length of working week for main job	1.0	1.1	2.5	-0.8	-0.7	1.5	-0.9	-0.3	-1.6
Exposure to tobacco smoke at home	0.6	0.6	1.1	-0.6	1.0	0.8	-0.6	0.5	-1.1
Breastfed as a baby	1.6	1.9	4.0	-0.8	1.7	2.0	-0.4	-1.7	-1.0
Tense / ‘highly strung’	0.5	0.9	1.6	0.8	0.3	1.3	-1.2	-1.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.4	0.4	-0.7	-0.2	-1.2	-0.5	0.0
Hair/balding pattern: Pattern 4	0.2	0.5	1.5	0.3	-0.3	-1.0	0.3	-1.2	0.6
Birth weight of first child	0.2	0.4	1.0	-1.0	0.4	-0.2	0.8	-0.6	-0.6
Peak expiratory flow (PEF)	0.8	2.0	4.7	-2.2	1.8	-0.8	1.5	-0.5	-0.9
Pulse wave reflection index	0.2	0.3	0.7	-0.1	-0.8	0.9	-0.1	-0.4	-0.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.1	-0.5	-0.8	0.1	1.7	-0.2	0.7
Loud music exposure frequency	0.7	0.8	1.7	-0.4	1.1	0.8	1.3	0.6	0.9
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.1	-1.8	1.1	-0.7	2.0	1.0	-0.4
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	5.7	-2.4	0.5	1.0	1.5	-0.8	-1.2
Blood clot in the leg (DVT)	1.8	2.3	7.5	2.7	-1.3	0.2	-1.5	-0.2	1.6
Medication: Paracetamol	0.7	1.2	3.0	1.7	0.2	-0.7	-1.2	-0.4	1.5
Headache pain in last month	0.4	0.7	1.4	-0.2	-0.7	-0.5	0.9	-1.2	1.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.8	-0.7	2.0	1.1	0.8	-0.3	-0.3
Glaucoma (self-reported)	1.5	1.7	6.2	-1.5	0.3	1.4	-0.2	-0.2	-2.5
Gout (self-reported)	1.6	2.1	6.2	1.7	-0.3	-2.5	0.1	-0.3	1.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.6	-0.3	-0.2	0.6	-1.9	0.9	-1.6
Medication: Amlodipine	0.9	1.2	3.3	0.3	-0.5	-1.0	1.6	0.1	1.8
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.4	1.9	0.2	-0.7	-1.5	0.5	1.7
Birth weight	1.1	2.4	5.0	-2.2	1.0	1.8	0.2	-0.8	-2.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.0	0.1	-0.6	1.4	-0.5	-0.3	-0.6
High blood pressure (siblings)	0.8	1.2	2.4	-0.8	0.7	1.1	-0.9	1.3	-1.5
Forced vital capacity (FVC), Best measure	0.8	2.9	8.0	-2.8	0.7	0.7	0.5	-1.3	-2.6
Body fat percentage	0.9	3.5	7.7	2.8	-1.8	-0.7	-2.2	-1.4	1.6
Leg fat percentage (right)	0.9	3.3	7.7	2.8	-0.9	-0.6	-1.7	-1.7	2.2
Arm fat-free mass (right)	1.0	5.0	20.0	0.2	-0.6	0.5	-4.5	-1.4	-2.7
Exposure to tobacco smoke outside home	0.4	0.5	1.4	0.5	0.4	0.8	-1.2	-0.9	-0.4
Comparative body size at age 10	0.3	1.0	2.3	1.4	0.5	-0.5	-1.5	0.8	0.7
Number of full brothers	0.3	0.4	1.0	-0.0	1.0	0.8	-0.0	0.7	0.4
Worry too long after embarrassment	2.6	4.4	10.8	3.3	-1.8	0.1	-2.4	-2.0	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.8	3.7	7.0	-0.9	2.6	1.6	-2.5	-0.7	-2.2
Wheeze or whistling in the chest in last year	1.7	3.1	8.6	2.9	-1.0	-0.7	-1.3	0.3	2.6
Number of children fathered	0.6	0.7	1.0	0.9	0.9	0.9	-0.7	-0.6	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	-1.1	0.5	1.3	0.5	0.3	-0.2
Age at first live birth	1.2	2.2	5.3	-2.3	1.4	0.0	2.1	-0.9	-0.9
Pulse wave peak to peak time	1.5	1.8	3.6	-1.8	0.7	-1.6	1.9	0.8	-0.3
Health satisfaction	2.0	2.5	5.8	2.4	-2.1	-0.1	-1.3	-0.4	1.8
Shortness of breath walking on level ground	3.1	3.7	12.3	2.3	-3.5	-0.5	-1.9	0.2	0.5
Qualifications: College or University degree	1.2	3.9	11.9	-3.0	1.4	0.3	0.2	0.8	-3.5
Eye problems/disorders: None of the above	0.5	0.6	1.9	0.4	-0.0	-1.4	0.6	-0.3	1.0
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.4	-0.8	0.7	0.3	-0.5	-0.3
Emphysema/chronic bronchitis	2.0	2.3	5.0	2.0	2.2	0.3	-1.4	-1.0	1.3
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	-0.6	0.4	0.0	-0.3	0.7	-0.9
Neck or shoulder pain in last month	0.2	0.3	0.8	0.4	0.2	0.7	-0.9	-0.7	-0.1
Medication: Blood pressure	0.3	0.5	1.9	0.3	-1.4	-0.9	0.1	0.3	0.6
Angina (self-reported)	1.6	2.1	4.2	1.8	-1.2	-0.8	0.3	-2.1	1.7
Migraine (self-reported)	1.0	1.2	2.5	1.6	-0.9	-0.4	-0.8	-1.4	1.0
Medication: Ibuprofen	0.5	0.6	1.5	0.4	1.0	0.6	0.4	-1.2	0.7
Medication: Allopurinol	1.5	2.0	4.8	1.6	-0.7	-2.2	-0.0	-1.0	1.8
Medication: Omeprazole	1.8	2.2	6.3	2.1	-0.5	-1.1	0.1	-0.9	2.5
Medication: Seretide 50 evohaler	1.0	1.2	2.6	1.4	-1.1	0.1	-1.6	-0.7	0.7
Mean time to correctly identify matches	0.5	1.0	2.7	0.6	-0.7	0.4	-1.7	0.7	-1.3
Heart disease (mother)	2.5	3.1	9.1	1.5	-2.4	-3.0	-0.0	0.3	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	0.6	0.6	-1.1	0.0	0.5	0.8
Whole body fat mass	0.8	3.5	10.6	2.4	-1.5	-0.3	-3.3	-1.6	0.5
Leg fat mass (right)	0.9	3.4	8.1	2.4	-1.0	-0.2	-2.9	-2.0	1.1
Arm predicted mass (right)	0.9	4.8	19.2	0.2	-0.4	0.4	-4.4	-1.4	-2.7
Pulse rate, automated reading	0.4	1.3	2.7	1.1	-1.2	1.3	-1.6	-0.7	0.6
Alcohol intake frequency.	0.9	2.1	5.9	2.4	1.2	0.1	-1.6	-1.1	1.4
Comparative height size at age 10	0.4	2.4	4.9	-0.6	-1.2	-0.9	-1.9	-1.7	-2.2
Number of full sisters	1.2	1.4	3.3	1.1	-0.4	1.8	-1.3	-1.1	0.9
Suffer from ‘nerves’	0.5	0.7	1.8	0.7	-0.2	1.3	-1.4	-0.6	-0.3
Overall health rating	2.1	4.4	8.1	2.9	-0.0	0.8	-2.8	-2.6	1.8
Chest pain or discomfort	0.4	0.5	1.3	0.7	-1.1	-0.4	-0.2	0.4	1.0
Had major operations	1.0	1.1	2.5	-0.1	-1.4	1.0	-1.6	0.5	-1.0
Age at last live birth	0.5	0.7	1.7	-1.3	0.5	0.5	1.2	-0.6	-0.1
Family relationship satisfaction	0.3	0.3	0.7	-0.2	-0.3	0.8	-0.3	-0.8	-0.5
Leg pain on walking	0.1	0.1	0.2	-0.2	0.5	0.2	0.1	0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	0.8	0.4	0.4	-0.8	-0.3	0.9
Commuting to job workplace: Car/motor vehicle	1.7	1.9	4.1	2.0	0.3	0.9	-0.1	-1.6	2.0
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.9	1.2	-1.2	-1.4	-0.9	0.1	0.5
Medication: Aspirin	1.2	1.6	3.8	-1.4	-0.6	-0.5	1.9	1.9	0.3
Supplements: Vitamin C	0.9	1.1	3.1	1.0	-0.1	0.4	0.4	-1.8	1.5
Knee pain experienced in last month	0.2	0.3	1.0	0.2	0.6	0.5	-1.0	0.1	-0.4
Hypertension (Self-reported)	0.6	1.6	5.6	1.0	-2.4	-1.1	-1.3	0.3	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.7	3.2	7.3	2.3	-2.3	-0.7	-0.1	-0.5	2.7
Illnesses of father: Heart disease	1.7	2.3	5.6	-2.4	1.9	0.6	0.7	0.2	-1.9
Illnesses of siblings: Diabetes	0.8	1.0	3.7	-0.5	-1.9	-0.5	-0.2	1.1	-0.7
Smoking status: Previous	0.3	0.5	1.6	-0.0	0.5	-0.3	0.2	-1.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	6.8	-1.3	-1.4	-0.2	-1.0	-0.2	-2.6
Whole body fat-free mass	0.9	5.0	18.5	-0.1	-0.2	0.6	-4.3	-1.4	-3.0
Leg fat-free mass (right)	0.8	4.4	19.5	0.8	-0.4	0.2	-4.4	-1.1	-2.1
Arm fat percentage (left)	0.8	3.2	7.7	2.8	-1.2	-0.0	-2.4	-1.5	1.4
Average weekly red wine intake	0.5	0.7	1.4	-1.0	-1.2	-0.1	0.5	-0.6	-1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.9	0.6	1.1	-0.2	-1.4	0.8	0.0
Mood swings	1.0	1.9	4.6	1.2	0.4	1.3	-1.9	-2.1	0.2
Loneliness, isolation	1.4	2.0	6.0	0.3	-0.0	2.5	-0.7	-2.3	0.0
Long-standing illness, disability or infirmity	0.8	1.2	2.5	1.0	-0.9	1.1	-1.6	-1.2	0.2
Ever had bowel cancer screening	1.0	1.2	4.5	1.1	-0.6	-2.1	0.4	-0.2	0.9
Diabetes diagnosed by doctor	0.9	1.4	3.7	1.1	-1.5	-1.1	-1.9	-0.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.3	0.1	0.5	-0.4	0.7	0.3
Friendships satisfaction	1.3	1.6	4.4	1.1	-0.6	1.5	-0.9	-2.1	0.5
Qualifications: nursing, teaching	1.8	2.9	6.9	-2.0	2.6	0.3	0.5	0.9	-2.2
Commuting to job workplace: Walk	2.0	2.2	5.3	-2.3	-1.2	0.8	0.6	0.4	-2.3
Eye problems/disorders: Cataract	0.4	0.4	1.2	1.0	-0.4	0.1	-0.2	0.1	1.1
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.2	0.9	-0.8	1.0	1.3	-1.6	2.0
Medication for cholesterol	0.4	0.6	1.5	0.7	-0.3	0.3	-1.2	-1.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.6	-0.7	-1.2	-0.9	1.2	-0.1	-0.1
Back pain experienced in last month	1.2	1.8	5.3	2.3	-0.1	-0.1	-0.5	-1.2	1.9
Mineral and other dietary supplements	0.8	1.1	3.3	0.5	-1.8	-0.6	-1.4	0.7	-0.7
Breast cancer (self-reported)	0.8	1.0	3.9	-0.9	1.0	2.0	0.2	-0.5	-0.2
Asthma (self-reported)	1.4	2.7	6.1	2.5	-1.0	-1.4	-0.8	-1.0	2.3
Osteoporosis (self-reported)	1.0	1.2	4.2	-0.3	-0.2	1.5	0.4	-2.0	-0.6
Osteoarthritis (self-reported)	0.4	0.5	1.1	-0.1	-0.9	1.1	0.4	0.8	-0.1
Medication: Aspirin	1.1	1.5	4.0	-1.1	-1.0	-0.5	1.5	2.0	0.5
Medication: Gliclazide	1.0	1.2	2.7	-1.6	1.6	-0.0	0.1	0.9	-1.0
Illnesses of father: None of the above (group 1)	1.0	1.3	3.6	0.9	-1.7	-0.6	0.1	-0.1	1.9
Smoking status: Current	0.6	1.0	1.8	-1.3	0.7	0.9	1.0	1.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.3	9.4	-3.1	2.4	1.7	2.0	-1.2	-1.6
Whole body water mass	0.9	5.1	19.2	-0.0	-0.3	0.6	-4.4	-1.4	-3.0
Leg predicted mass (right)	0.8	4.2	19.0	0.7	-0.4	0.1	-4.4	-1.0	-2.2
Arm fat mass (left)	0.9	3.5	11.7	2.4	-1.2	-0.1	-3.4	-1.5	0.4
Number of self-reported non-cancer illnesses	1.3	2.3	3.9	1.9	-2.0	-0.1	-1.8	-1.6	0.7
Average weekly champagne plus white wine intake	0.5	0.7	1.6	-1.3	1.0	-0.5	0.8	0.7	-0.6
Miserableness	0.9	1.5	3.5	1.4	0.6	0.7	-1.5	-1.9	0.3
Guilty feelings	0.8	1.3	4.9	0.5	-0.9	-0.0	0.2	-2.2	1.3
Wears glasses or contact lenses	0.9	1.0	1.8	1.1	-1.4	0.5	-1.1	-1.3	0.2
Ever taken oral contraceptive pill	1.0	1.1	2.3	0.5	-0.4	1.5	-1.4	-1.3	0.1
Hearing aid user	0.4	0.5	1.5	-0.3	-1.2	0.5	-0.7	0.6	-0.1
Mother’s age at death	0.6	0.8	1.6	-1.1	-0.3	1.3	0.9	0.2	-0.9
Financial situation satisfaction	2.0	2.5	5.5	1.7	-2.4	-0.4	0.1	-1.5	2.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.8	-0.6	1.2	0.5	1.3	0.6	-0.1
Commuting to job workplace: Public transport	2.7	3.3	7.6	-1.8	1.1	-1.9	2.8	1.8	0.8
Eye problems/disorders: Glaucoma	1.4	1.6	4.2	-1.0	0.4	1.6	-0.5	-1.2	-2.1
Medication: Blood pressure	0.5	0.9	2.0	0.7	-0.7	-1.3	-0.1	1.4	0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.6	-0.4	-0.4	0.2	-0.7	0.2
Supplements: Fish oil (including cod liver oil)	1.0	1.2	2.7	0.4	1.3	0.3	1.5	-0.7	1.6
High cholesterol (Self-reported)	0.9	1.5	4.2	1.0	-2.0	-1.8	-0.0	0.2	0.9
Medication: Bendroflumethiazide	0.8	1.3	2.8	-0.7	-1.4	-1.7	1.2	1.0	0.1
Medication: Paracetamol	0.7	1.1	2.4	1.6	-0.2	-1.1	-0.8	-0.3	1.5
Medication: Lisinopril	0.4	0.6	1.8	0.3	0.6	-0.3	-1.0	1.3	-0.3
Medication: Atorvastatin	0.0	0.1	0.1	0.3	0.0	0.3	-0.3	-0.1	-0.1
Illnesses of father: High blood pressure	0.7	0.9	3.0	-1.1	0.5	0.2	-0.4	0.7	-1.7
Alcohol drinker status: Never	0.6	0.7	2.2	-1.0	0.2	1.5	-0.2	0.6	-0.8
Ever smoked	0.6	1.0	2.7	-1.6	0.7	-0.0	1.3	1.0	-0.2
Basal metabolic rate	0.9	4.9	20.3	0.5	-0.5	0.3	-4.5	-1.5	-2.5
Leg fat percentage (left)	0.9	3.1	7.4	2.7	-1.2	-0.6	-2.0	-1.5	1.8
Arm fat-free mass (left)	0.9	4.8	18.7	0.0	-0.3	0.2	-4.3	-1.4	-2.9
Number of operations (self-reported)	0.9	1.3	5.3	1.1	-0.8	-0.5	-2.3	0.4	0.3
Average weekly beer plus cider intake	1.4	2.1	6.4	-1.0	2.5	0.7	-0.4	1.7	-1.3
Irritability	0.9	1.5	3.6	-0.4	0.8	1.2	-0.9	-1.9	-1.5
Risk taking	0.9	1.3	3.0	1.3	1.1	-0.5	-0.4	-1.0	1.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.8	0.2	-1.7	-0.4	0.4	-0.7	0.0
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.5	-0.3	0.1	-0.3	0.6	-0.2
Age started oral contraceptive pill	1.4	1.7	4.0	0.8	-1.3	-2.0	-0.2	1.9	0.3
Diastolic blood pressure, automated reading	0.5	1.4	3.8	1.3	-1.5	0.2	-2.0	-0.7	0.2
Ever depressed for a whole week	0.4	0.5	1.4	-1.1	-0.1	-0.1	1.2	-0.4	-0.0
Unable to work because of sickness or disability	0.3	0.4	1.2	1.1	-0.2	0.2	-0.9	-0.6	-0.1
Commuting to job workplace: Cycle	1.3	1.5	7.4	-0.3	2.7	0.4	-1.2	0.5	-0.2
Myopia	0.2	0.3	1.2	0.2	0.6	1.1	-0.3	-0.6	-0.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.4	-1.0	2.1	1.0	0.9	-0.2	-0.4
Cholesterol lowering medication	0.5	0.8	1.6	0.9	-1.3	-1.1	0.3	-0.0	0.9
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	6.6	2.6	-1.4	-1.2	-0.4	-0.8	2.5
Pain experienced in last month	0.3	0.6	2.8	-0.1	-0.8	-0.2	-0.1	1.7	-0.0
Supplements: Calcium	1.8	2.0	7.1	0.2	0.8	2.0	0.3	-2.7	0.3
Basal cell carcinoma (self-reported)	1.0	1.2	3.2	-0.9	-1.8	1.4	0.5	1.0	-0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	0.4	-0.5	-0.4	0.3	-1.1	0.7
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	8.2	2.9	-1.2	0.4	-1.9	-0.1	1.5
Heart disease (siblings)	0.5	0.6	2.4	-0.3	0.6	-0.1	1.0	1.6	0.1
Alcohol drinker status: Previous	0.5	0.6	2.4	-0.1	1.5	-0.9	-0.3	-0.1	-0.3
Pack years of smoking	0.5	0.8	1.8	1.3	0.6	1.2	0.0	-0.1	1.0
Impedance of whole body	0.3	1.3	5.4	-0.9	-0.5	-1.1	2.3	0.3	-0.0
Leg fat mass (left)	0.8	3.3	9.4	2.3	-1.0	-0.2	-3.1	-1.8	0.7
Arm predicted mass (left)	1.0	4.9	21.2	0.5	-0.5	0.1	-4.6	-1.4	-2.5