Hub : Genes

FBXL3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1787	0.0486	2.5e-06	0.073	NA	0.069	NA	0.068	2.4e-06	NA	4.5e-06	NA	5.1e-06
2	GTEx	Nerve Tibial	0.1873	0.0596	4.2e-04	0.083	NA	0.067	NA	0.067	1.7e-06	NA	1.8e-05	NA	1.6e-05
3	METSIM	Adipose	0.0582	0.0193	6.2e-06	0.027	0.037	0.034	0.044	0.047	5.3e-05	2.6e-06	5.5e-06	3.5e-07	1.2e-07
4	TCGA	Prostate Adenocarcinoma	0.0583	0.0287	1.4e-03	0.016	0.021	0.029	NA	0.033	7.6e-03	2.6e-03	4.4e-04	NA	2.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	0.9	2.4	-1.0	0.1	-0.4	1.6
Bipolar Disorder or Schizophrenia	0.5	1.1	2.0	-0.8	-1.2	-1.4	0.8
Depressed Affect (Nagel 2018)	1.3	2.8	6.4	0.1	-0.8	2.5	-2.1
Depression (Nagel 2018)	0.6	0.9	2.2	0.1	-0.5	1.1	-1.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.5	0.5	-1.2	-0.5	0.4
Neuroticism (Nagel 2018)	1.8	4.3	9.7	1.2	-0.3	2.5	-3.1
Schizophrenia (2018)	0.5	1.1	2.3	-0.1	-1.5	-1.4	-0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	2.1	1.5	0.2	0.1	0.1
Worry (Nagel 2018)	1.6	3.3	9.8	0.9	-0.4	1.6	-3.1
Alzheimer’s Disease (in mother)	3.3	3.9	7.0	-1.6	-2.6	-0.9	2.3
Alzheimer’s Disease (in father)	0.4	0.4	0.9	-0.9	-0.7	0.1	0.5
Alzheimer’s Disease (including proxy)	1.7	2.4	5.1	-1.7	-2.3	-0.2	1.3
Crohns Disease (2017)	0.3	0.6	1.5	-0.7	-1.2	-0.6	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.9	-0.6	-0.0	0.0
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.7	0.3	0.6	0.2
Major Depression (MDD)	0.7	0.8	2.3	0.2	0.2	1.0	1.5
Reaction Time	1.4	2.7	5.5	-1.5	-2.3	-0.4	1.7
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	0.7	-0.1	-0.1	-0.5
Breast Cancer	0.3	0.6	1.1	-0.6	0.6	1.1	0.8
Ovarian Cancer	0.4	0.5	0.7	-0.8	-0.7	-0.9	-0.3
Prostate Cancer	0.9	1.2	2.1	-1.4	-1.1	1.2	-0.5
Age at First Birth	0.3	0.4	0.6	-0.0	0.8	0.8	0.6
Bipolar Disorder (2011)	0.6	0.6	1.3	-0.7	0.2	0.7	1.1
Body Mass Index (BMI) (2010)	0.4	0.6	1.9	-0.6	0.1	-0.3	1.4
Coronary Artery Disease (CAD)	0.3	0.4	1.0	0.3	-1.0	0.1	-0.7
Crohns Disease (2012)	2.9	4.6	7.4	-1.7	-2.7	-2.6	1.2
Mean Putamen Volume	1.0	1.1	2.3	-1.1	-1.5	-0.2	1.0
Fasting Glucose	0.3	0.3	0.8	0.9	-0.2	-0.0	0.6
HbA1C	0.2	0.3	0.8	0.5	-0.1	0.9	-0.1
HDL Cholesterol	0.5	0.8	1.7	-0.5	-1.0	-0.7	1.3
LDL Cholesterol	0.3	0.4	1.2	1.1	0.0	-0.5	0.5
Lupus	0.1	0.2	0.5	-0.5	0.0	-0.7	0.4
Neuroticism (2016)	1.6	2.3	7.2	1.2	0.6	0.4	-2.7
Primary Biliary Cirrhosis	0.6	0.9	1.4	-0.5	-1.2	-1.0	0.9
Rheumatoid Arthritis	0.9	1.3	3.2	0.2	-0.4	-1.4	1.8
Schizophrenia (2014)	0.5	1.2	2.3	-0.6	-1.4	-1.5	0.4
Triglycerides	0.5	0.8	3.0	1.7	0.1	-0.2	-0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.7	-0.1	-1.1	-1.3	0.2
Ulcerative Colitis	0.2	0.4	0.8	-0.9	0.0	0.7	0.4
Blood Eosinophil Count	0.4	2.7	5.6	-1.7	-1.1	-1.1	2.4
Blood Platelet Count	0.1	1.6	3.6	0.7	1.9	1.5	0.5
Blood Red Count	0.8	7.3	11.8	3.4	2.7	2.0	-2.4
Blood White Count	0.3	2.3	7.4	2.7	1.3	0.5	0.1
Heel T-Score	0.5	4.2	6.1	2.3	2.2	0.8	-2.5
BMI	0.1	0.5	1.7	1.3	0.2	0.3	0.3
Height	0.2	4.6	13.2	-1.6	-1.6	-0.2	3.6
Waist Hip Ratio (WHR)	0.1	0.4	1.6	-0.1	-0.3	1.3	0.0
Systolic Blood Pressure	1.2	5.9	14.6	2.6	1.4	0.1	-3.8
Smoking Status	0.4	1.0	1.6	1.3	0.7	1.0	-0.9
Allergy or Eczema	1.2	3.2	5.2	-2.3	-1.6	-1.1	2.0
Cardiovascular Disease	0.4	1.2	2.5	-0.2	-0.8	1.6	-1.3
Hypothyroidism (self reported)	0.9	2.0	5.0	-1.5	-0.9	0.3	2.2
Respiratory disease	0.6	1.4	4.3	-0.4	-0.8	-2.1	0.6
Type 2 Diabetes (T2D) (2018)	1.5	2.9	6.7	-0.5	-2.6	-0.5	2.0
Lung FEV1/FVC ratio	0.1	0.3	0.8	-0.9	-0.1	0.6	-0.3
Lung FVC	0.8	4.1	10.8	-2.3	0.2	-0.7	3.3
Neuroticism	1.5	3.5	8.6	1.7	0.6	1.5	-2.9
Chronotype (morning person)	4.9	11.2	39.2	6.3	1.6	-1.7	-0.6
Hair Pigment	0.0	1.4	4.8	-0.1	-0.8	-0.3	2.2
Tanning	0.1	1.0	3.2	0.1	0.6	-1.8	0.7
Hand grip strength (left)	0.3	0.9	1.8	-0.5	1.2	-0.4	1.3
Number of treatments/medications taken	0.2	0.3	0.7	0.8	-0.5	-0.1	-0.4
Average weekly spirits intake	1.0	1.3	2.5	1.1	1.6	1.2	0.5
Sensitivity / hurt feelings	1.2	2.1	4.2	2.0	0.6	0.3	-2.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	0.2	-0.4	0.9	-0.6
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.3	0.3	0.6	-0.2
Relative age of first facial hair	1.0	2.0	3.7	1.3	1.6	1.9	0.3
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.0	-1.4	-1.0	1.1	-0.8
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	-0.4	-1.2	-0.0	0.5
Ever had hysterectomy (womb removed)	0.5	0.5	1.0	1.0	0.8	-0.3	0.6
Systolic blood pressure, automated reading	0.5	1.6	3.0	1.7	0.5	-0.2	-1.7
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	4.0	-1.9	-2.0	1.1	2.0
Angina	0.4	0.5	1.7	0.4	0.2	-0.1	-1.3
Medication for hormone replacement therapy	2.0	2.2	7.3	2.7	0.7	0.1	-1.0
Vitamin and mineral supplements	0.4	0.5	1.5	-0.1	-0.7	0.3	-1.2
Supplements: Zinc	1.2	1.3	3.4	-1.9	-1.0	0.3	0.7
Medication: Co-codamol	0.5	0.6	1.2	0.4	1.1	0.9	0.5
Medication: Metformin	1.4	1.9	3.7	-1.0	-1.5	-0.8	1.9
Diabetes (father)	0.4	0.5	0.7	0.6	0.8	-0.7	0.7
Diabetes (mother)	0.0	0.0	0.1	0.2	-0.2	0.1	0.3
Severe depression (siblings)	0.9	1.0	1.9	1.4	0.9	-1.1	0.6
Pack years adult smoking proportion	0.6	1.0	1.9	0.0	0.3	1.4	-1.4
Impedance of leg (right)	0.8	3.9	5.9	0.7	2.4	2.0	-2.3
Leg fat-free mass (left)	0.3	1.7	3.2	-0.1	-1.8	-0.7	1.7
Trunk fat percentage	0.8	3.4	7.6	1.5	1.2	2.8	-1.5
Hand grip strength (right)	0.2	0.5	1.3	-0.1	1.1	0.4	0.8
Townsend deprivation index at recruitment	0.0	0.1	0.1	0.4	-0.2	0.2	-0.1
Current tobacco smoking	0.4	0.6	1.1	0.9	0.8	1.0	0.1
Average weekly fortified wine intake	0.2	0.2	0.5	0.1	0.0	0.5	-0.7
Maternal smoking around birth	2.0	2.9	4.9	1.8	1.3	1.3	-2.2
Fed-up feelings	1.8	3.3	5.6	1.5	0.3	2.4	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.8	0.2	-0.4	1.3	-0.5
Relative age voice broke	1.1	1.7	2.9	0.6	1.3	1.7	1.4
Taking other prescription medications	0.1	0.1	0.4	-0.2	0.7	0.0	0.0
Age when periods started (menarche)	0.2	0.6	1.2	0.8	0.6	-0.2	1.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.8	-0.2	-0.1	-0.4	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	0.4	0.8	0.1	0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.5	0.3	-0.1	-0.2
Qualifications: CSEs or equivalent	1.2	1.5	4.1	1.0	0.7	0.7	-2.0
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-0.6	0.4	1.0	0.2
High blood pressure	0.4	1.0	1.7	-0.1	-1.3	0.8	-1.3
Hayfever, allergic rhinitis or eczema	2.3	4.9	8.4	-2.9	-2.4	-1.3	2.0
Multivitamins +/- minerals	0.9	1.1	4.2	-0.1	0.5	-0.1	2.0
Stomach or abdominal pain in last month	2.0	2.5	6.7	2.6	1.2	1.3	-0.3
Supplements: Glucosamine	0.1	0.1	0.5	-0.1	-0.1	-0.7	-0.1
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.6	0.2	1.4	2.2	-1.8
Medication: Atenolol	2.4	3.0	6.4	2.2	0.3	0.8	-2.5
Medication: Levothyroxine sodium	1.2	2.0	7.4	-0.7	-0.4	-0.0	2.7
Sitting height	0.2	1.3	4.5	0.2	-0.6	-0.4	2.1
Chronic bronchitis/emphysema (father)	0.8	1.0	1.4	0.4	1.2	1.0	-1.1
High blood pressure (mother)	1.3	1.9	4.9	2.2	0.6	0.6	-1.4
Body mass index (BMI)	0.1	0.5	1.4	1.2	0.1	0.6	-0.4
Impedance of leg (left)	1.2	5.9	9.3	1.0	3.1	2.8	-2.3
Leg predicted mass (left)	0.3	1.8	3.4	-0.2	-1.8	-0.7	1.8
Trunk fat mass	0.3	1.3	3.6	1.1	0.4	1.9	-0.4
Waist circumference	0.1	0.4	0.6	0.6	-0.7	0.7	0.4
Number of incorrect matches in round	0.0	0.1	0.1	0.1	0.3	-0.2	0.3
Past tobacco smoking	0.6	1.0	2.7	-1.6	-0.4	0.1	1.1
Alcohol usually taken with meals	1.1	1.7	4.6	-0.1	-1.3	-2.1	0.8
Nervous feelings	2.1	3.9	10.3	1.9	0.3	1.4	-3.2
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	7.6	1.4	0.3	1.6	-2.8
Hearing difficulty/problems with background noise	0.4	0.6	1.2	0.6	0.6	0.7	-1.1
Hair/balding pattern: Pattern 2	1.3	1.7	3.3	1.3	1.2	-0.5	-1.8
Had menopause	0.5	0.6	1.2	-1.1	-0.3	-0.4	1.1
Had other major operations	0.1	0.2	0.5	0.7	-0.4	-0.1	-0.1
Forced vital capacity (FVC)	0.9	3.6	11.5	-1.3	-1.0	-0.6	3.4
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	0.2	-0.2	0.5	-0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	0.5	-0.5	-0.6	-0.3
Qualifications: None of the above	0.5	1.2	3.2	0.4	0.6	1.0	-1.8
Financial difficulties in last 2 years	0.4	0.6	1.9	0.0	0.1	0.7	-1.4
Mouth/teeth dental problems	1.6	2.5	6.7	-0.8	-1.5	-2.6	0.6
Heart attack	1.1	1.3	3.3	-0.8	-1.1	-0.5	-1.8
Allergy	1.3	2.9	3.2	1.8	1.6	1.7	-1.8
Pain all over the body in last month	1.7	1.9	5.7	0.2	1.1	0.8	-2.4
Diabetes (self-reported)	0.9	1.4	2.8	-0.1	-1.7	-0.2	1.7
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.4	-1.8	-1.8	-0.2	-0.1
Medication: Ramipril	0.7	0.9	2.5	0.6	-0.6	-0.6	-1.6
Medication: Simvastatin	0.5	0.8	2.1	0.3	0.3	0.9	-1.5
Fluid intelligence score	0.5	1.1	2.1	1.5	-0.1	-1.4	-0.3
Illnesses of siblings	2.5	3.5	10.5	-1.3	-0.2	-1.3	3.2
Neuroticism score	2.0	4.2	8.2	1.9	0.8	2.1	-2.9
Weight	0.1	0.5	1.2	0.5	-0.9	0.3	1.1
Impedance of arm (right)	0.9	4.3	10.3	0.4	1.9	3.2	-1.7
Arm fat percentage (right)	0.5	2.1	5.0	1.4	0.8	2.2	-1.0
Trunk fat-free mass	1.0	6.0	9.4	-1.3	-3.1	-2.2	2.8
Hip circumference	0.1	0.4	0.8	0.4	-0.9	-0.1	0.8
Time employed in main current job	1.0	1.2	2.1	0.9	0.9	-1.5	-0.9
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.5	-0.2	-0.4	0.6
Father’s age at death	0.4	0.6	1.8	0.3	0.3	-0.5	1.3
Worrier / anxious feelings	0.2	0.3	1.0	0.3	-0.3	0.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	7.6	1.4	1.5	2.2	-2.8
Falls in the last year	0.7	0.9	1.7	-0.8	-0.7	0.9	1.3
Hair/balding pattern: Pattern 3	0.8	1.2	2.3	-1.3	-1.5	-0.3	0.9
Number of live births	0.3	0.4	0.9	0.0	-0.9	0.2	-0.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	5.3	-0.6	-0.6	-0.2	2.3
Pulse rate	0.2	0.3	1.0	-1.0	-0.5	-0.2	0.0
Happiness	1.2	1.4	3.1	1.6	-0.0	-0.0	-1.8
Noisy workplace	2.0	2.5	4.4	-2.1	-0.3	1.8	-1.5
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.2	1.5	0.6	-0.4	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.2	-1.1	-0.9	0.3	0.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.6	0.0	0.5	0.4	1.3
Asthma	0.5	0.9	3.4	0.2	-0.2	-1.8	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	0.5	0.1	0.0	0.9
Medication: Cholesterol lowering	0.1	0.1	0.3	0.5	0.0	-0.1	-0.4
Depression (self-reported)	0.4	0.5	1.4	0.0	0.3	-0.7	1.2
Medication: Lansoprazole	2.9	3.3	7.8	-1.1	0.3	2.1	-2.8
Prospective memory result	0.5	0.6	1.3	-1.0	-0.3	-0.1	1.1
Lung cancer (father)	0.2	0.2	0.6	0.3	0.2	0.7	-0.1
Illnesses of mother	0.5	0.6	0.9	-1.0	-0.7	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.1	-1.1	-0.2	1.1	2.0
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	-0.8	-0.8	0.0	0.4
Impedance of arm (left)	0.8	3.6	7.6	0.6	2.1	2.8	-1.5
Arm fat mass (right)	0.2	0.8	2.0	1.1	0.2	1.4	-0.2
Trunk predicted mass	1.1	6.0	9.3	-1.4	-3.0	-2.2	2.9
Standing height	0.4	3.6	8.2	-1.3	-2.1	-0.6	2.9
Length of working week for main job	0.5	0.5	0.8	0.9	0.9	-0.4	0.6
Exposure to tobacco smoke at home	1.5	1.7	3.2	-1.7	-1.8	-0.1	0.9
Breastfed as a baby	3.4	4.2	7.3	-1.8	-2.7	-2.1	1.2
Tense / ‘highly strung’	1.9	3.1	8.0	0.6	0.3	1.9	-2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.4	1.6	-0.8	0.8	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	0.1	-1.1	0.1	1.0
Birth weight of first child	1.7	3.0	4.2	-1.6	-1.1	-2.1	2.0
Peak expiratory flow (PEF)	0.4	1.0	2.2	1.5	0.2	-1.3	0.4
Pulse wave reflection index	1.9	2.3	4.0	2.0	-1.0	-0.6	2.0
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.8	0.3	0.1	0.9	-0.9
Loud music exposure frequency	0.7	0.7	1.6	-1.1	-0.3	-0.2	1.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.9	-0.1	0.3	-0.1	1.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.2	1.5	1.4	1.1	-1.0
Blood clot in the leg (DVT)	1.3	1.6	3.2	-1.8	-1.6	-0.3	0.9
Medication: Paracetamol	1.5	2.5	3.0	1.6	1.7	1.7	-1.3
Headache pain in last month	0.4	0.7	1.4	0.9	0.4	0.5	1.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.8	-0.2	-0.1	-0.4	0.9
Glaucoma (self-reported)	0.9	1.1	2.6	0.2	0.4	1.2	-1.6
Gout (self-reported)	0.6	0.9	1.8	0.7	1.3	-1.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.8	-1.0	-0.5	0.5	2.2
Medication: Amlodipine	0.3	0.4	1.1	-0.5	-1.1	0.1	-0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.0	-0.5	-0.4	0.4
Birth weight	0.4	0.8	1.3	1.0	0.4	-1.1	0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	-0.6	-0.3	-1.0	0.6
High blood pressure (siblings)	0.4	0.6	1.1	0.7	-0.5	0.6	-1.1
Forced vital capacity (FVC), Best measure	0.7	2.7	8.6	-1.3	-0.5	0.4	2.9
Body fat percentage	0.9	3.7	7.7	1.8	1.4	2.8	-1.4
Leg fat percentage (right)	0.7	2.4	3.9	1.5	1.1	2.0	-1.4
Arm fat-free mass (right)	0.7	3.8	6.3	-0.8	-2.2	-1.8	2.5
Exposure to tobacco smoke outside home	0.2	0.3	0.6	-0.5	0.3	0.8	0.6
Comparative body size at age 10	0.0	0.1	0.2	0.4	0.0	-0.4	0.3
Number of full brothers	1.9	2.4	6.7	0.4	-0.2	1.7	-2.6
Worry too long after embarrassment	2.1	3.6	7.2	2.7	1.4	0.7	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.6	-0.2	-0.5	-0.9
Wheeze or whistling in the chest in last year	0.1	0.2	0.8	0.2	0.0	-0.1	-0.9
Number of children fathered	0.3	0.3	1.0	0.3	0.1	1.0	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	6.3	2.5	0.5	-0.3	-1.4
Age at first live birth	0.1	0.2	0.4	-0.1	0.2	-0.6	-0.4
Pulse wave peak to peak time	0.2	0.2	0.5	0.7	0.6	-0.1	-0.2
Health satisfaction	1.0	1.4	2.1	1.4	1.0	1.5	-0.6
Shortness of breath walking on level ground	2.6	3.1	5.4	2.1	0.9	1.4	-2.3
Qualifications: College or University degree	0.4	1.1	2.7	1.2	0.7	-0.1	1.6
Eye problems/disorders: None of the above	0.8	1.0	2.9	0.8	0.3	-1.7	-0.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.0	0.0	1.1	-0.3	-1.7
Emphysema/chronic bronchitis	1.0	1.2	3.6	1.9	0.4	0.6	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.9	1.9	-0.5	-0.2	-1.1	1.4
Neck or shoulder pain in last month	1.3	1.8	6.8	2.6	0.2	0.7	-0.2
Medication: Blood pressure	0.3	0.5	1.9	0.4	-0.1	0.2	-1.4
Angina (self-reported)	0.5	0.7	2.3	0.4	0.4	0.1	-1.5
Migraine (self-reported)	3.5	4.3	15.1	-0.3	-1.0	-1.0	3.9
Medication: Ibuprofen	0.3	0.3	0.9	1.0	0.4	0.2	0.3
Medication: Allopurinol	0.6	0.8	1.7	1.1	1.3	-0.6	-0.1
Medication: Omeprazole	0.6	0.7	1.8	-0.2	-1.3	-0.9	-0.5
Medication: Seretide 50 evohaler	0.8	0.9	2.3	0.7	-1.5	0.3	-0.9
Mean time to correctly identify matches	1.7	3.2	6.5	-1.3	-2.2	-0.3	2.5
Heart disease (mother)	0.4	0.5	1.1	1.1	0.6	-0.6	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	-0.3	0.6	0.0	-0.9
Whole body fat mass	0.4	1.5	2.9	1.5	0.6	1.7	-0.6
Leg fat mass (right)	0.3	1.3	2.3	1.5	0.8	1.4	-0.6
Arm predicted mass (right)	0.6	3.2	5.3	-0.6	-2.1	-1.6	2.3
Pulse rate, automated reading	0.4	1.4	3.4	0.2	1.9	0.7	-1.2
Alcohol intake frequency.	0.9	2.1	3.6	-1.2	-1.9	-1.0	1.6
Comparative height size at age 10	0.6	3.2	6.2	-2.4	-2.5	-0.5	0.5
Number of full sisters	0.2	0.2	0.8	-0.1	0.4	0.9	0.0
Suffer from ‘nerves’	1.8	2.8	6.2	2.0	0.0	1.1	-2.5
Overall health rating	1.1	2.4	6.2	1.6	0.6	0.8	-2.5
Chest pain or discomfort	0.7	1.1	2.8	0.7	0.0	1.0	-1.7
Had major operations	2.0	2.3	4.0	1.7	-0.5	-2.0	1.4
Age at last live birth	0.8	1.1	2.0	-1.4	-1.0	0.5	-1.1
Family relationship satisfaction	0.4	0.5	1.1	0.8	0.1	0.3	-1.0
Leg pain on walking	0.5	0.6	1.2	-1.1	-0.8	0.7	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.0	-1.7	-2.0	0.1	0.2
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.5	-0.1	0.6	-1.2	-0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	0.3	-0.4	-1.0	0.9
Medication: Aspirin	0.6	0.7	2.3	-0.4	-1.5	0.5	-0.5
Supplements: Vitamin C	1.8	2.2	4.2	1.9	2.1	0.4	-0.7
Knee pain experienced in last month	0.1	0.1	0.3	0.2	-0.1	0.1	0.6
Hypertension (Self-reported)	0.3	0.8	1.4	0.5	-1.2	0.6	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	5.5	0.8	0.1	0.6	-2.3
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.1	0.8	-0.5	-0.5
Illnesses of siblings: Diabetes	1.4	1.7	3.3	-0.8	-1.8	-1.4	-1.0
Smoking status: Previous	0.2	0.3	1.0	0.5	-0.1	0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.1	0.3	0.2	1.1	0.2
Whole body fat-free mass	0.8	4.3	7.1	-0.9	-2.6	-1.6	2.7
Leg fat-free mass (right)	0.4	1.9	4.1	-0.3	-1.7	-0.6	2.0
Arm fat percentage (left)	0.5	2.1	4.2	1.6	0.9	2.1	-1.0
Average weekly red wine intake	0.2	0.2	0.8	0.2	0.3	-0.2	0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	-0.6	0.5	0.7	1.1
Mood swings	0.6	1.0	2.2	0.4	-1.3	1.5	-0.0
Loneliness, isolation	0.9	1.2	1.9	-0.9	-1.3	1.4	-0.7
Long-standing illness, disability or infirmity	0.7	1.1	2.3	-1.1	-0.9	1.5	-0.4
Ever had bowel cancer screening	0.3	0.3	0.9	-0.1	-0.3	0.6	-1.0
Diabetes diagnosed by doctor	0.6	1.0	2.1	-0.3	-1.4	0.4	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.8	0.3	1.2	0.5	-1.3
Friendships satisfaction	3.0	3.7	10.1	3.2	1.1	-0.2	-1.8
Qualifications: nursing, teaching	0.3	0.5	1.2	0.3	1.1	-0.7	0.5
Commuting to job workplace: Walk	1.0	1.0	3.1	-1.0	-1.8	-0.1	-0.3
Eye problems/disorders: Cataract	0.8	0.9	2.6	-0.4	-0.7	1.6	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	6.2	0.1	-0.2	2.5	-1.0
Medication for cholesterol	0.3	0.4	1.0	0.1	0.7	-1.0	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.3	1.5	0.8	0.5	-0.5
Back pain experienced in last month	0.4	0.6	1.6	-0.4	0.2	1.3	0.6
Mineral and other dietary supplements	2.0	2.7	8.6	0.6	0.6	2.9	-1.2
Breast cancer (self-reported)	0.5	0.6	1.2	-0.7	-0.7	0.3	1.1
Asthma (self-reported)	0.5	1.0	3.8	0.1	-0.4	-1.9	-0.2
Osteoporosis (self-reported)	0.7	0.9	2.0	0.0	-0.4	-1.2	-1.4
Osteoarthritis (self-reported)	0.5	0.7	2.0	0.4	1.4	0.7	0.2
Medication: Aspirin	0.5	0.6	2.0	-0.0	-1.4	0.0	-0.7
Medication: Gliclazide	4.0	4.5	6.7	-2.0	-2.3	-1.4	2.6
Illnesses of father: None of the above (group 1)	0.6	0.7	1.2	-0.8	-0.3	0.9	1.1
Smoking status: Current	0.3	0.5	0.9	0.9	0.6	0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.7	-0.9	-0.1	-0.6	1.3
Whole body water mass	0.7	4.1	6.7	-0.9	-2.6	-1.5	2.6
Leg predicted mass (right)	0.3	1.8	3.9	-0.3	-1.7	-0.6	2.0
Arm fat mass (left)	0.2	0.9	1.8	1.3	0.3	1.3	-0.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	0.4	-0.8	-0.5	-1.0
Average weekly champagne plus white wine intake	1.0	1.3	3.1	-1.3	-1.8	-0.2	0.7
Miserableness	2.8	4.8	9.6	2.0	0.7	3.1	-2.2
Guilty feelings	1.7	2.5	5.6	0.9	-0.0	1.9	-2.4
Wears glasses or contact lenses	2.9	3.3	7.1	-0.8	-1.4	-1.9	2.7
Ever taken oral contraceptive pill	0.4	0.5	1.3	-1.1	0.4	-0.6	-0.4
Hearing aid user	0.9	1.0	1.8	-1.3	-0.6	1.3	0.6
Mother’s age at death	0.1	0.2	0.4	0.2	0.6	0.1	0.4
Financial situation satisfaction	0.9	1.2	2.3	-0.8	-1.3	1.5	0.2
Tinnitus: Yes, now most or all of the time	2.5	3.0	6.5	-2.5	-0.7	0.1	2.2
Commuting to job workplace: Public transport	0.8	0.9	1.3	0.7	1.1	1.1	0.9
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	0.2	0.5	0.4	-0.8
Medication: Blood pressure	0.5	0.9	3.1	-0.6	-1.8	0.0	-0.4
Pain type(s) experienced in last month: Hip pain	1.4	1.8	4.7	0.1	1.2	2.2	0.9
Supplements: Fish oil (including cod liver oil)	2.0	2.7	6.7	-0.9	-1.3	-2.6	1.2
High cholesterol (Self-reported)	0.0	0.1	0.1	0.3	-0.1	0.3	-0.2
Medication: Bendroflumethiazide	0.4	0.6	1.2	0.9	0.3	0.4	-1.1
Medication: Paracetamol	2.0	3.1	5.1	2.2	1.9	1.5	-1.2
Medication: Lisinopril	0.1	0.2	0.4	-0.4	0.1	0.4	-0.6
Medication: Atorvastatin	0.2	0.3	0.4	0.7	-0.6	-0.6	0.4
Illnesses of father: High blood pressure	0.2	0.3	0.6	0.7	-0.8	-0.1	-0.0
Alcohol drinker status: Never	2.1	2.6	6.8	-0.4	-1.1	-1.4	2.6
Ever smoked	0.9	1.6	5.0	2.2	0.5	0.0	-1.0
Basal metabolic rate	0.4	2.5	4.5	-0.5	-2.1	-1.0	2.0
Leg fat percentage (left)	0.9	3.3	6.1	1.6	1.6	2.5	-1.5
Arm fat-free mass (left)	0.5	2.4	4.4	-0.6	-1.8	-1.3	2.1
Number of operations (self-reported)	1.0	1.5	4.9	2.2	-0.7	-0.8	0.0
Average weekly beer plus cider intake	1.2	1.8	3.3	-1.1	1.8	1.6	-0.1
Irritability	1.0	1.7	3.4	-1.4	-0.6	1.8	-1.0
Risk taking	2.2	3.2	6.5	1.8	2.5	0.7	1.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.5	-0.1	0.1	0.7
Fractured/broken bones in last 5 years	2.1	2.7	5.6	-0.9	-1.6	-2.4	1.3
Age started oral contraceptive pill	0.9	1.1	2.3	-1.4	0.3	0.6	-1.5
Diastolic blood pressure, automated reading	0.8	2.6	4.7	2.2	1.3	0.3	-2.0
Ever depressed for a whole week	0.1	0.1	0.2	-0.2	-0.2	0.3	-0.5
Unable to work because of sickness or disability	0.5	0.6	1.3	-0.2	0.1	1.1	-1.1
Commuting to job workplace: Cycle	0.5	0.6	0.9	0.2	0.9	0.9	0.7
Myopia	0.9	1.3	1.5	1.1	-1.2	-1.1	-1.1
Vascular/heart problems diagnosed by doctor	0.5	1.2	2.6	0.2	1.2	-0.9	1.6
Cholesterol lowering medication	0.2	0.3	0.5	-0.5	-0.5	0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-0.1	-1.0	-0.3	-0.5
Pain experienced in last month	0.3	0.5	1.4	-0.5	-0.5	-1.2	0.4
Supplements: Calcium	0.3	0.3	0.7	-0.2	0.6	0.3	0.8
Basal cell carcinoma (self-reported)	0.8	0.9	2.3	-0.8	-0.8	-1.5	-0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.1	-0.5	-0.6	-0.5	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.5	-1.5	-1.6	-0.4	0.9
Heart disease (siblings)	3.2	3.9	10.2	2.0	0.9	0.8	-3.2
Alcohol drinker status: Previous	0.0	0.0	0.1	-0.1	0.1	0.3	-0.1
Pack years of smoking	0.4	0.6	1.5	-0.2	0.1	1.2	-1.0
Impedance of whole body	1.0	5.2	8.4	1.1	2.7	2.9	-2.0
Leg fat mass (left)	0.4	1.7	2.7	1.6	1.0	1.7	-0.6
Arm predicted mass (left)	0.5	2.7	4.5	-0.5	-2.1	-1.4	2.0