Hub : Genes

FBXL3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1787 0.0486 2.5e-06 0.073 NA 0.069 NA 0.068 2.4e-06 NA 4.5e-06 NA 5.1e-06
2 GTEx Nerve Tibial 0.1873 0.0596 4.2e-04 0.083 NA 0.067 NA 0.067 1.7e-06 NA 1.8e-05 NA 1.6e-05
3 METSIM Adipose 0.0582 0.0193 6.2e-06 0.027 0.037 0.034 0.044 0.047 5.3e-05 2.6e-06 5.5e-06 3.5e-07 1.2e-07
4 TCGA Prostate Adenocarcinoma 0.0583 0.0287 1.4e-03 0.016 0.021 0.029 NA 0.033 7.6e-03 2.6e-03 4.4e-04 NA 2.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.6 0.9 2.4 -1.0 0.1 -0.4 1.6
Bipolar Disorder or Schizophrenia 0.5 1.1 2.0 -0.8 -1.2 -1.4 0.8
Depressed Affect (Nagel 2018) 1.3 2.8 6.4 0.1 -0.8 2.5 -2.1
Depression (Nagel 2018) 0.6 0.9 2.2 0.1 -0.5 1.1 -1.5
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.5 0.5 -1.2 -0.5 0.4
Neuroticism (Nagel 2018) 1.8 4.3 9.7 1.2 -0.3 2.5 -3.1
Schizophrenia (2018) 0.5 1.1 2.3 -0.1 -1.5 -1.4 -0.3
Schizophrenia vs Biploar Disorder 0.4 0.5 2.1 1.5 0.2 0.1 0.1
Worry (Nagel 2018) 1.6 3.3 9.8 0.9 -0.4 1.6 -3.1
Alzheimer’s Disease (in mother) 3.3 3.9 7.0 -1.6 -2.6 -0.9 2.3
Alzheimer’s Disease (in father) 0.4 0.4 0.9 -0.9 -0.7 0.1 0.5
Alzheimer’s Disease (including proxy) 1.7 2.4 5.1 -1.7 -2.3 -0.2 1.3
Crohns Disease (2017) 0.3 0.6 1.5 -0.7 -1.2 -0.6 -0.2
Irritable Bowel Disease (IBD) 0.1 0.3 0.8 -0.9 -0.6 -0.0 0.0
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.7 0.3 0.6 0.2
Major Depression (MDD) 0.7 0.8 2.3 0.2 0.2 1.0 1.5
Reaction Time 1.4 2.7 5.5 -1.5 -2.3 -0.4 1.7
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.5 0.7 -0.1 -0.1 -0.5
Breast Cancer 0.3 0.6 1.1 -0.6 0.6 1.1 0.8
Ovarian Cancer 0.4 0.5 0.7 -0.8 -0.7 -0.9 -0.3
Prostate Cancer 0.9 1.2 2.1 -1.4 -1.1 1.2 -0.5
Age at First Birth 0.3 0.4 0.6 -0.0 0.8 0.8 0.6
Bipolar Disorder (2011) 0.6 0.6 1.3 -0.7 0.2 0.7 1.1
Body Mass Index (BMI) (2010) 0.4 0.6 1.9 -0.6 0.1 -0.3 1.4
Coronary Artery Disease (CAD) 0.3 0.4 1.0 0.3 -1.0 0.1 -0.7
Crohns Disease (2012) 2.9 4.6 7.4 -1.7 -2.7 -2.6 1.2
Mean Putamen Volume 1.0 1.1 2.3 -1.1 -1.5 -0.2 1.0
Fasting Glucose 0.3 0.3 0.8 0.9 -0.2 -0.0 0.6
HbA1C 0.2 0.3 0.8 0.5 -0.1 0.9 -0.1
HDL Cholesterol 0.5 0.8 1.7 -0.5 -1.0 -0.7 1.3
LDL Cholesterol 0.3 0.4 1.2 1.1 0.0 -0.5 0.5
Lupus 0.1 0.2 0.5 -0.5 0.0 -0.7 0.4
Neuroticism (2016) 1.6 2.3 7.2 1.2 0.6 0.4 -2.7
Primary Biliary Cirrhosis 0.6 0.9 1.4 -0.5 -1.2 -1.0 0.9
Rheumatoid Arthritis 0.9 1.3 3.2 0.2 -0.4 -1.4 1.8
Schizophrenia (2014) 0.5 1.2 2.3 -0.6 -1.4 -1.5 0.4
Triglycerides 0.5 0.8 3.0 1.7 0.1 -0.2 -0.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.7 -0.1 -1.1 -1.3 0.2
Ulcerative Colitis 0.2 0.4 0.8 -0.9 0.0 0.7 0.4
Blood Eosinophil Count 0.4 2.7 5.6 -1.7 -1.1 -1.1 2.4
Blood Platelet Count 0.1 1.6 3.6 0.7 1.9 1.5 0.5
Blood Red Count 0.8 7.3 11.8 3.4 2.7 2.0 -2.4
Blood White Count 0.3 2.3 7.4 2.7 1.3 0.5 0.1
Heel T-Score 0.5 4.2 6.1 2.3 2.2 0.8 -2.5
BMI 0.1 0.5 1.7 1.3 0.2 0.3 0.3
Height 0.2 4.6 13.2 -1.6 -1.6 -0.2 3.6
Waist Hip Ratio (WHR) 0.1 0.4 1.6 -0.1 -0.3 1.3 0.0
Systolic Blood Pressure 1.2 5.9 14.6 2.6 1.4 0.1 -3.8
Smoking Status 0.4 1.0 1.6 1.3 0.7 1.0 -0.9
Allergy or Eczema 1.2 3.2 5.2 -2.3 -1.6 -1.1 2.0
Cardiovascular Disease 0.4 1.2 2.5 -0.2 -0.8 1.6 -1.3
Hypothyroidism (self reported) 0.9 2.0 5.0 -1.5 -0.9 0.3 2.2
Respiratory disease 0.6 1.4 4.3 -0.4 -0.8 -2.1 0.6
Type 2 Diabetes (T2D) (2018) 1.5 2.9 6.7 -0.5 -2.6 -0.5 2.0
Lung FEV1/FVC ratio 0.1 0.3 0.8 -0.9 -0.1 0.6 -0.3
Lung FVC 0.8 4.1 10.8 -2.3 0.2 -0.7 3.3
Neuroticism 1.5 3.5 8.6 1.7 0.6 1.5 -2.9
Chronotype (morning person) 4.9 11.2 39.2 6.3 1.6 -1.7 -0.6
Hair Pigment 0.0 1.4 4.8 -0.1 -0.8 -0.3 2.2
Tanning 0.1 1.0 3.2 0.1 0.6 -1.8 0.7
Hand grip strength (left) 0.3 0.9 1.8 -0.5 1.2 -0.4 1.3
Number of treatments/medications taken 0.2 0.3 0.7 0.8 -0.5 -0.1 -0.4
Average weekly spirits intake 1.0 1.3 2.5 1.1 1.6 1.2 0.5
Sensitivity / hurt feelings 1.2 2.1 4.2 2.0 0.6 0.3 -2.0
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.8 0.2 -0.4 0.9 -0.6
Hearing difficulty/problems: Yes 0.1 0.1 0.3 -0.3 0.3 0.6 -0.2
Relative age of first facial hair 1.0 2.0 3.7 1.3 1.6 1.9 0.3
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 2.0 -1.4 -1.0 1.1 -0.8
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.4 -0.4 -1.2 -0.0 0.5
Ever had hysterectomy (womb removed) 0.5 0.5 1.0 1.0 0.8 -0.3 0.6
Systolic blood pressure, automated reading 0.5 1.6 3.0 1.7 0.5 -0.2 -1.7
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 4.0 -1.9 -2.0 1.1 2.0
Angina 0.4 0.5 1.7 0.4 0.2 -0.1 -1.3
Medication for hormone replacement therapy 2.0 2.2 7.3 2.7 0.7 0.1 -1.0
Vitamin and mineral supplements 0.4 0.5 1.5 -0.1 -0.7 0.3 -1.2
Supplements: Zinc 1.2 1.3 3.4 -1.9 -1.0 0.3 0.7
Medication: Co-codamol 0.5 0.6 1.2 0.4 1.1 0.9 0.5
Medication: Metformin 1.4 1.9 3.7 -1.0 -1.5 -0.8 1.9
Diabetes (father) 0.4 0.5 0.7 0.6 0.8 -0.7 0.7
Diabetes (mother) 0.0 0.0 0.1 0.2 -0.2 0.1 0.3
Severe depression (siblings) 0.9 1.0 1.9 1.4 0.9 -1.1 0.6
Pack years adult smoking proportion 0.6 1.0 1.9 0.0 0.3 1.4 -1.4
Impedance of leg (right) 0.8 3.9 5.9 0.7 2.4 2.0 -2.3
Leg fat-free mass (left) 0.3 1.7 3.2 -0.1 -1.8 -0.7 1.7
Trunk fat percentage 0.8 3.4 7.6 1.5 1.2 2.8 -1.5
Hand grip strength (right) 0.2 0.5 1.3 -0.1 1.1 0.4 0.8
Townsend deprivation index at recruitment 0.0 0.1 0.1 0.4 -0.2 0.2 -0.1
Current tobacco smoking 0.4 0.6 1.1 0.9 0.8 1.0 0.1
Average weekly fortified wine intake 0.2 0.2 0.5 0.1 0.0 0.5 -0.7
Maternal smoking around birth 2.0 2.9 4.9 1.8 1.3 1.3 -2.2
Fed-up feelings 1.8 3.3 5.6 1.5 0.3 2.4 -2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.8 0.2 -0.4 1.3 -0.5
Relative age voice broke 1.1 1.7 2.9 0.6 1.3 1.7 1.4
Taking other prescription medications 0.1 0.1 0.4 -0.2 0.7 0.0 0.0
Age when periods started (menarche) 0.2 0.6 1.2 0.8 0.6 -0.2 1.1
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.8 -0.2 -0.1 -0.4 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.6 0.4 0.8 0.1 0.3
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 0.5 0.3 -0.1 -0.2
Qualifications: CSEs or equivalent 1.2 1.5 4.1 1.0 0.7 0.7 -2.0
Serious illness, injury or assault to yourself 0.3 0.4 1.0 -0.6 0.4 1.0 0.2
High blood pressure 0.4 1.0 1.7 -0.1 -1.3 0.8 -1.3
Hayfever, allergic rhinitis or eczema 2.3 4.9 8.4 -2.9 -2.4 -1.3 2.0
Multivitamins +/- minerals 0.9 1.1 4.2 -0.1 0.5 -0.1 2.0
Stomach or abdominal pain in last month 2.0 2.5 6.7 2.6 1.2 1.3 -0.3
Supplements: Glucosamine 0.1 0.1 0.5 -0.1 -0.1 -0.7 -0.1
Diverticular disease/diverticulitis (self-reported) 2.0 2.4 4.6 0.2 1.4 2.2 -1.8
Medication: Atenolol 2.4 3.0 6.4 2.2 0.3 0.8 -2.5
Medication: Levothyroxine sodium 1.2 2.0 7.4 -0.7 -0.4 -0.0 2.7
Sitting height 0.2 1.3 4.5 0.2 -0.6 -0.4 2.1
Chronic bronchitis/emphysema (father) 0.8 1.0 1.4 0.4 1.2 1.0 -1.1
High blood pressure (mother) 1.3 1.9 4.9 2.2 0.6 0.6 -1.4
Body mass index (BMI) 0.1 0.5 1.4 1.2 0.1 0.6 -0.4
Impedance of leg (left) 1.2 5.9 9.3 1.0 3.1 2.8 -2.3
Leg predicted mass (left) 0.3 1.8 3.4 -0.2 -1.8 -0.7 1.8
Trunk fat mass 0.3 1.3 3.6 1.1 0.4 1.9 -0.4
Waist circumference 0.1 0.4 0.6 0.6 -0.7 0.7 0.4
Number of incorrect matches in round 0.0 0.1 0.1 0.1 0.3 -0.2 0.3
Past tobacco smoking 0.6 1.0 2.7 -1.6 -0.4 0.1 1.1
Alcohol usually taken with meals 1.1 1.7 4.6 -0.1 -1.3 -2.1 0.8
Nervous feelings 2.1 3.9 10.3 1.9 0.3 1.4 -3.2
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.1 7.6 1.4 0.3 1.6 -2.8
Hearing difficulty/problems with background noise 0.4 0.6 1.2 0.6 0.6 0.7 -1.1
Hair/balding pattern: Pattern 2 1.3 1.7 3.3 1.3 1.2 -0.5 -1.8
Had menopause 0.5 0.6 1.2 -1.1 -0.3 -0.4 1.1
Had other major operations 0.1 0.2 0.5 0.7 -0.4 -0.1 -0.1
Forced vital capacity (FVC) 0.9 3.6 11.5 -1.3 -1.0 -0.6 3.4
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 0.2 -0.2 0.5 -0.3
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.3 0.5 -0.5 -0.6 -0.3
Qualifications: None of the above 0.5 1.2 3.2 0.4 0.6 1.0 -1.8
Financial difficulties in last 2 years 0.4 0.6 1.9 0.0 0.1 0.7 -1.4
Mouth/teeth dental problems 1.6 2.5 6.7 -0.8 -1.5 -2.6 0.6
Heart attack 1.1 1.3 3.3 -0.8 -1.1 -0.5 -1.8
Allergy 1.3 2.9 3.2 1.8 1.6 1.7 -1.8
Pain all over the body in last month 1.7 1.9 5.7 0.2 1.1 0.8 -2.4
Diabetes (self-reported) 0.9 1.4 2.8 -0.1 -1.7 -0.2 1.7
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 3.4 -1.8 -1.8 -0.2 -0.1
Medication: Ramipril 0.7 0.9 2.5 0.6 -0.6 -0.6 -1.6
Medication: Simvastatin 0.5 0.8 2.1 0.3 0.3 0.9 -1.5
Fluid intelligence score 0.5 1.1 2.1 1.5 -0.1 -1.4 -0.3
Illnesses of siblings 2.5 3.5 10.5 -1.3 -0.2 -1.3 3.2
Neuroticism score 2.0 4.2 8.2 1.9 0.8 2.1 -2.9
Weight 0.1 0.5 1.2 0.5 -0.9 0.3 1.1
Impedance of arm (right) 0.9 4.3 10.3 0.4 1.9 3.2 -1.7
Arm fat percentage (right) 0.5 2.1 5.0 1.4 0.8 2.2 -1.0
Trunk fat-free mass 1.0 6.0 9.4 -1.3 -3.1 -2.2 2.8
Hip circumference 0.1 0.4 0.8 0.4 -0.9 -0.1 0.8
Time employed in main current job 1.0 1.2 2.1 0.9 0.9 -1.5 -0.9
Alcohol intake versus 10 years previously 0.1 0.2 0.4 0.5 -0.2 -0.4 0.6
Father’s age at death 0.4 0.6 1.8 0.3 0.3 -0.5 1.3
Worrier / anxious feelings 0.2 0.3 1.0 0.3 -0.3 0.3 -1.0
Frequency of tiredness / lethargy in last 2 weeks 2.6 4.2 7.6 1.4 1.5 2.2 -2.8
Falls in the last year 0.7 0.9 1.7 -0.8 -0.7 0.9 1.3
Hair/balding pattern: Pattern 3 0.8 1.2 2.3 -1.3 -1.5 -0.3 0.9
Number of live births 0.3 0.4 0.9 0.0 -0.9 0.2 -0.9
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 5.3 -0.6 -0.6 -0.2 2.3
Pulse rate 0.2 0.3 1.0 -1.0 -0.5 -0.2 0.0
Happiness 1.2 1.4 3.1 1.6 -0.0 -0.0 -1.8
Noisy workplace 2.0 2.5 4.4 -2.1 -0.3 1.8 -1.5
Qualifications: A levels/AS levels or equivalent 0.3 0.8 2.2 1.5 0.6 -0.4 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.2 -1.1 -0.9 0.3 0.1
Mouth/teeth dental problems: Dentures 0.3 0.5 1.6 0.0 0.5 0.4 1.3
Asthma 0.5 0.9 3.4 0.2 -0.2 -1.8 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.8 0.5 0.1 0.0 0.9
Medication: Cholesterol lowering 0.1 0.1 0.3 0.5 0.0 -0.1 -0.4
Depression (self-reported) 0.4 0.5 1.4 0.0 0.3 -0.7 1.2
Medication: Lansoprazole 2.9 3.3 7.8 -1.1 0.3 2.1 -2.8
Prospective memory result 0.5 0.6 1.3 -1.0 -0.3 -0.1 1.1
Lung cancer (father) 0.2 0.2 0.6 0.3 0.2 0.7 -0.1
Illnesses of mother 0.5 0.6 0.9 -1.0 -0.7 -0.9 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 4.1 -1.1 -0.2 1.1 2.0
Pulse wave Arterial Stiffness index 0.3 0.4 0.7 -0.8 -0.8 0.0 0.4
Impedance of arm (left) 0.8 3.6 7.6 0.6 2.1 2.8 -1.5
Arm fat mass (right) 0.2 0.8 2.0 1.1 0.2 1.4 -0.2
Trunk predicted mass 1.1 6.0 9.3 -1.4 -3.0 -2.2 2.9
Standing height 0.4 3.6 8.2 -1.3 -2.1 -0.6 2.9
Length of working week for main job 0.5 0.5 0.8 0.9 0.9 -0.4 0.6
Exposure to tobacco smoke at home 1.5 1.7 3.2 -1.7 -1.8 -0.1 0.9
Breastfed as a baby 3.4 4.2 7.3 -1.8 -2.7 -2.1 1.2
Tense / ‘highly strung’ 1.9 3.1 8.0 0.6 0.3 1.9 -2.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.4 1.6 -0.8 0.8 0.2
Hair/balding pattern: Pattern 4 0.2 0.5 1.1 0.1 -1.1 0.1 1.0
Birth weight of first child 1.7 3.0 4.2 -1.6 -1.1 -2.1 2.0
Peak expiratory flow (PEF) 0.4 1.0 2.2 1.5 0.2 -1.3 0.4
Pulse wave reflection index 1.9 2.3 4.0 2.0 -1.0 -0.6 2.0
Ever highly irritable/argumentative for 2 days 0.4 0.4 0.8 0.3 0.1 0.9 -0.9
Loud music exposure frequency 0.7 0.7 1.6 -1.1 -0.3 -0.2 1.3
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.9 -0.1 0.3 -0.1 1.4
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 2.2 1.5 1.4 1.1 -1.0
Blood clot in the leg (DVT) 1.3 1.6 3.2 -1.8 -1.6 -0.3 0.9
Medication: Paracetamol 1.5 2.5 3.0 1.6 1.7 1.7 -1.3
Headache pain in last month 0.4 0.7 1.4 0.9 0.4 0.5 1.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.8 -0.2 -0.1 -0.4 0.9
Glaucoma (self-reported) 0.9 1.1 2.6 0.2 0.4 1.2 -1.6
Gout (self-reported) 0.6 0.9 1.8 0.7 1.3 -1.0 -0.4
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 4.8 -1.0 -0.5 0.5 2.2
Medication: Amlodipine 0.3 0.4 1.1 -0.5 -1.1 0.1 -0.2
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 0.0 -0.5 -0.4 0.4
Birth weight 0.4 0.8 1.3 1.0 0.4 -1.1 0.9
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.0 -0.6 -0.3 -1.0 0.6
High blood pressure (siblings) 0.4 0.6 1.1 0.7 -0.5 0.6 -1.1
Forced vital capacity (FVC), Best measure 0.7 2.7 8.6 -1.3 -0.5 0.4 2.9
Body fat percentage 0.9 3.7 7.7 1.8 1.4 2.8 -1.4
Leg fat percentage (right) 0.7 2.4 3.9 1.5 1.1 2.0 -1.4
Arm fat-free mass (right) 0.7 3.8 6.3 -0.8 -2.2 -1.8 2.5
Exposure to tobacco smoke outside home 0.2 0.3 0.6 -0.5 0.3 0.8 0.6
Comparative body size at age 10 0.0 0.1 0.2 0.4 0.0 -0.4 0.3
Number of full brothers 1.9 2.4 6.7 0.4 -0.2 1.7 -2.6
Worry too long after embarrassment 2.1 3.6 7.2 2.7 1.4 0.7 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.9 0.6 -0.2 -0.5 -0.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.8 0.2 0.0 -0.1 -0.9
Number of children fathered 0.3 0.3 1.0 0.3 0.1 1.0 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 6.3 2.5 0.5 -0.3 -1.4
Age at first live birth 0.1 0.2 0.4 -0.1 0.2 -0.6 -0.4
Pulse wave peak to peak time 0.2 0.2 0.5 0.7 0.6 -0.1 -0.2
Health satisfaction 1.0 1.4 2.1 1.4 1.0 1.5 -0.6
Shortness of breath walking on level ground 2.6 3.1 5.4 2.1 0.9 1.4 -2.3
Qualifications: College or University degree 0.4 1.1 2.7 1.2 0.7 -0.1 1.6
Eye problems/disorders: None of the above 0.8 1.0 2.9 0.8 0.3 -1.7 -0.5
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.0 0.0 1.1 -0.3 -1.7
Emphysema/chronic bronchitis 1.0 1.2 3.6 1.9 0.4 0.6 -0.8
Medication for pain relief, constipation, heartburn 0.5 0.9 1.9 -0.5 -0.2 -1.1 1.4
Neck or shoulder pain in last month 1.3 1.8 6.8 2.6 0.2 0.7 -0.2
Medication: Blood pressure 0.3 0.5 1.9 0.4 -0.1 0.2 -1.4
Angina (self-reported) 0.5 0.7 2.3 0.4 0.4 0.1 -1.5
Migraine (self-reported) 3.5 4.3 15.1 -0.3 -1.0 -1.0 3.9
Medication: Ibuprofen 0.3 0.3 0.9 1.0 0.4 0.2 0.3
Medication: Allopurinol 0.6 0.8 1.7 1.1 1.3 -0.6 -0.1
Medication: Omeprazole 0.6 0.7 1.8 -0.2 -1.3 -0.9 -0.5
Medication: Seretide 50 evohaler 0.8 0.9 2.3 0.7 -1.5 0.3 -0.9
Mean time to correctly identify matches 1.7 3.2 6.5 -1.3 -2.2 -0.3 2.5
Heart disease (mother) 0.4 0.5 1.1 1.1 0.6 -0.6 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.8 -0.3 0.6 0.0 -0.9
Whole body fat mass 0.4 1.5 2.9 1.5 0.6 1.7 -0.6
Leg fat mass (right) 0.3 1.3 2.3 1.5 0.8 1.4 -0.6
Arm predicted mass (right) 0.6 3.2 5.3 -0.6 -2.1 -1.6 2.3
Pulse rate, automated reading 0.4 1.4 3.4 0.2 1.9 0.7 -1.2
Alcohol intake frequency. 0.9 2.1 3.6 -1.2 -1.9 -1.0 1.6
Comparative height size at age 10 0.6 3.2 6.2 -2.4 -2.5 -0.5 0.5
Number of full sisters 0.2 0.2 0.8 -0.1 0.4 0.9 0.0
Suffer from ‘nerves’ 1.8 2.8 6.2 2.0 0.0 1.1 -2.5
Overall health rating 1.1 2.4 6.2 1.6 0.6 0.8 -2.5
Chest pain or discomfort 0.7 1.1 2.8 0.7 0.0 1.0 -1.7
Had major operations 2.0 2.3 4.0 1.7 -0.5 -2.0 1.4
Age at last live birth 0.8 1.1 2.0 -1.4 -1.0 0.5 -1.1
Family relationship satisfaction 0.4 0.5 1.1 0.8 0.1 0.3 -1.0
Leg pain on walking 0.5 0.6 1.2 -1.1 -0.8 0.7 -0.2
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 4.0 -1.7 -2.0 0.1 0.2
Commuting to job workplace: Car/motor vehicle 0.6 0.6 1.5 -0.1 0.6 -1.2 -0.8
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.1 0.3 -0.4 -1.0 0.9
Medication: Aspirin 0.6 0.7 2.3 -0.4 -1.5 0.5 -0.5
Supplements: Vitamin C 1.8 2.2 4.2 1.9 2.1 0.4 -0.7
Knee pain experienced in last month 0.1 0.1 0.3 0.2 -0.1 0.1 0.6
Hypertension (Self-reported) 0.3 0.8 1.4 0.5 -1.2 0.6 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.6 5.5 0.8 0.1 0.6 -2.3
Illnesses of father: Heart disease 0.2 0.3 0.6 -0.1 0.8 -0.5 -0.5
Illnesses of siblings: Diabetes 1.4 1.7 3.3 -0.8 -1.8 -1.4 -1.0
Smoking status: Previous 0.2 0.3 1.0 0.5 -0.1 0.3 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 1.1 0.3 0.2 1.1 0.2
Whole body fat-free mass 0.8 4.3 7.1 -0.9 -2.6 -1.6 2.7
Leg fat-free mass (right) 0.4 1.9 4.1 -0.3 -1.7 -0.6 2.0
Arm fat percentage (left) 0.5 2.1 4.2 1.6 0.9 2.1 -1.0
Average weekly red wine intake 0.2 0.2 0.8 0.2 0.3 -0.2 0.9
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.2 -0.6 0.5 0.7 1.1
Mood swings 0.6 1.0 2.2 0.4 -1.3 1.5 -0.0
Loneliness, isolation 0.9 1.2 1.9 -0.9 -1.3 1.4 -0.7
Long-standing illness, disability or infirmity 0.7 1.1 2.3 -1.1 -0.9 1.5 -0.4
Ever had bowel cancer screening 0.3 0.3 0.9 -0.1 -0.3 0.6 -1.0
Diabetes diagnosed by doctor 0.6 1.0 2.1 -0.3 -1.4 0.4 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.8 0.3 1.2 0.5 -1.3
Friendships satisfaction 3.0 3.7 10.1 3.2 1.1 -0.2 -1.8
Qualifications: nursing, teaching 0.3 0.5 1.2 0.3 1.1 -0.7 0.5
Commuting to job workplace: Walk 1.0 1.0 3.1 -1.0 -1.8 -0.1 -0.3
Eye problems/disorders: Cataract 0.8 0.9 2.6 -0.4 -0.7 1.6 -0.5
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 6.2 0.1 -0.2 2.5 -1.0
Medication for cholesterol 0.3 0.4 1.0 0.1 0.7 -1.0 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 2.3 1.5 0.8 0.5 -0.5
Back pain experienced in last month 0.4 0.6 1.6 -0.4 0.2 1.3 0.6
Mineral and other dietary supplements 2.0 2.7 8.6 0.6 0.6 2.9 -1.2
Breast cancer (self-reported) 0.5 0.6 1.2 -0.7 -0.7 0.3 1.1
Asthma (self-reported) 0.5 1.0 3.8 0.1 -0.4 -1.9 -0.2
Osteoporosis (self-reported) 0.7 0.9 2.0 0.0 -0.4 -1.2 -1.4
Osteoarthritis (self-reported) 0.5 0.7 2.0 0.4 1.4 0.7 0.2
Medication: Aspirin 0.5 0.6 2.0 -0.0 -1.4 0.0 -0.7
Medication: Gliclazide 4.0 4.5 6.7 -2.0 -2.3 -1.4 2.6
Illnesses of father: None of the above (group 1) 0.6 0.7 1.2 -0.8 -0.3 0.9 1.1
Smoking status: Current 0.3 0.5 0.9 0.9 0.6 0.9 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.7 -0.9 -0.1 -0.6 1.3
Whole body water mass 0.7 4.1 6.7 -0.9 -2.6 -1.5 2.6
Leg predicted mass (right) 0.3 1.8 3.9 -0.3 -1.7 -0.6 2.0
Arm fat mass (left) 0.2 0.9 1.8 1.3 0.3 1.3 -0.3
Number of self-reported non-cancer illnesses 0.3 0.5 1.0 0.4 -0.8 -0.5 -1.0
Average weekly champagne plus white wine intake 1.0 1.3 3.1 -1.3 -1.8 -0.2 0.7
Miserableness 2.8 4.8 9.6 2.0 0.7 3.1 -2.2
Guilty feelings 1.7 2.5 5.6 0.9 -0.0 1.9 -2.4
Wears glasses or contact lenses 2.9 3.3 7.1 -0.8 -1.4 -1.9 2.7
Ever taken oral contraceptive pill 0.4 0.5 1.3 -1.1 0.4 -0.6 -0.4
Hearing aid user 0.9 1.0 1.8 -1.3 -0.6 1.3 0.6
Mother’s age at death 0.1 0.2 0.4 0.2 0.6 0.1 0.4
Financial situation satisfaction 0.9 1.2 2.3 -0.8 -1.3 1.5 0.2
Tinnitus: Yes, now most or all of the time 2.5 3.0 6.5 -2.5 -0.7 0.1 2.2
Commuting to job workplace: Public transport 0.8 0.9 1.3 0.7 1.1 1.1 0.9
Eye problems/disorders: Glaucoma 0.2 0.3 0.6 0.2 0.5 0.4 -0.8
Medication: Blood pressure 0.5 0.9 3.1 -0.6 -1.8 0.0 -0.4
Pain type(s) experienced in last month: Hip pain 1.4 1.8 4.7 0.1 1.2 2.2 0.9
Supplements: Fish oil (including cod liver oil) 2.0 2.7 6.7 -0.9 -1.3 -2.6 1.2
High cholesterol (Self-reported) 0.0 0.1 0.1 0.3 -0.1 0.3 -0.2
Medication: Bendroflumethiazide 0.4 0.6 1.2 0.9 0.3 0.4 -1.1
Medication: Paracetamol 2.0 3.1 5.1 2.2 1.9 1.5 -1.2
Medication: Lisinopril 0.1 0.2 0.4 -0.4 0.1 0.4 -0.6
Medication: Atorvastatin 0.2 0.3 0.4 0.7 -0.6 -0.6 0.4
Illnesses of father: High blood pressure 0.2 0.3 0.6 0.7 -0.8 -0.1 -0.0
Alcohol drinker status: Never 2.1 2.6 6.8 -0.4 -1.1 -1.4 2.6
Ever smoked 0.9 1.6 5.0 2.2 0.5 0.0 -1.0
Basal metabolic rate 0.4 2.5 4.5 -0.5 -2.1 -1.0 2.0
Leg fat percentage (left) 0.9 3.3 6.1 1.6 1.6 2.5 -1.5
Arm fat-free mass (left) 0.5 2.4 4.4 -0.6 -1.8 -1.3 2.1
Number of operations (self-reported) 1.0 1.5 4.9 2.2 -0.7 -0.8 0.0
Average weekly beer plus cider intake 1.2 1.8 3.3 -1.1 1.8 1.6 -0.1
Irritability 1.0 1.7 3.4 -1.4 -0.6 1.8 -1.0
Risk taking 2.2 3.2 6.5 1.8 2.5 0.7 1.7
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 -0.5 -0.1 0.1 0.7
Fractured/broken bones in last 5 years 2.1 2.7 5.6 -0.9 -1.6 -2.4 1.3
Age started oral contraceptive pill 0.9 1.1 2.3 -1.4 0.3 0.6 -1.5
Diastolic blood pressure, automated reading 0.8 2.6 4.7 2.2 1.3 0.3 -2.0
Ever depressed for a whole week 0.1 0.1 0.2 -0.2 -0.2 0.3 -0.5
Unable to work because of sickness or disability 0.5 0.6 1.3 -0.2 0.1 1.1 -1.1
Commuting to job workplace: Cycle 0.5 0.6 0.9 0.2 0.9 0.9 0.7
Myopia 0.9 1.3 1.5 1.1 -1.2 -1.1 -1.1
Vascular/heart problems diagnosed by doctor 0.5 1.2 2.6 0.2 1.2 -0.9 1.6
Cholesterol lowering medication 0.2 0.3 0.5 -0.5 -0.5 0.7 0.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.1 -0.1 -1.0 -0.3 -0.5
Pain experienced in last month 0.3 0.5 1.4 -0.5 -0.5 -1.2 0.4
Supplements: Calcium 0.3 0.3 0.7 -0.2 0.6 0.3 0.8
Basal cell carcinoma (self-reported) 0.8 0.9 2.3 -0.8 -0.8 -1.5 -0.2
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.1 -0.5 -0.6 -0.5 -1.8
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.5 -1.5 -1.6 -0.4 0.9
Heart disease (siblings) 3.2 3.9 10.2 2.0 0.9 0.8 -3.2
Alcohol drinker status: Previous 0.0 0.0 0.1 -0.1 0.1 0.3 -0.1
Pack years of smoking 0.4 0.6 1.5 -0.2 0.1 1.2 -1.0
Impedance of whole body 1.0 5.2 8.4 1.1 2.7 2.9 -2.0
Leg fat mass (left) 0.4 1.7 2.7 1.6 1.0 1.7 -0.6
Arm predicted mass (left) 0.5 2.7 4.5 -0.5 -2.1 -1.4 2.0