TWAS hub - FBXO17

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2290	0.0420	1.8e-09	0.187	0.081	0.196	0.171	0.191	3.5e-22	4.5e-10	2.3e-23	2.7e-20	9.7e-23
2	TCGA	Breast Invasive Carcinoma	0.0300	0.0152	1.7e-03	0.004	0.010	0.009	NA	0.002	4.9e-02	2.6e-03	4.7e-03	NA	1.2e-01
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0465	0.0211	6.6e-04	0.018	0.030	0.015	NA	0.014	3.7e-03	2.5e-04	7.1e-03	NA	8.4e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0671	0.0253	2.3e-05	0.007	0.047	0.045	NA	0.032	4.4e-02	5.0e-06	8.2e-06	NA	1.4e-04
5	TCGA	Brain Lower Grade Glioma	0.0443	0.0230	1.9e-03	0.018	0.024	0.015	NA	0.017	3.7e-03	8.2e-04	6.5e-03	NA	4.5e-03
6	TCGA	Prostate Adenocarcinoma	0.1309	0.0456	8.4e-08	0.075	0.075	0.090	NA	0.089	2.9e-08	3.0e-08	1.1e-09	NA	1.6e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Diabetes (father)	12.4	15.4	20.1	3.2	3.4	4.5	4.0	4.4	3.9
Mineral and other dietary supplements	10.9	14.6	20.2	-3.4	-4.4	-2.7	-3.8	-4.5	-3.8
Supplements: Fish oil (including cod liver oil)	10.1	13.2	19.2	3.3	4.0	2.4	3.5	4.4	3.8
Diabetes (mother)	7.8	9.9	13.5	3.3	2.2	3.0	3.7	2.8	3.6
Supplements: Glucosamine	5.9	7.6	12.0	2.7	3.3	2.2	2.2	3.5	2.5
Illnesses of siblings: Diabetes	5.3	6.5	8.8	2.1	2.7	2.3	3.0	2.5	2.6
Chronic bronchitis/emphysema (father)	4.7	5.5	6.9	2.3	2.5	2.2	2.2	2.6	2.4
Comparative height size at age 10	4.6	25.5	46.6	4.2	4.6	6.8	5.0	5.1	4.2
Number of incorrect matches in round	4.5	7.4	8.8	3.0	2.6	2.2	2.8	2.7	2.9
Pulse rate	4.3	7.2	11.6	-3.4	-3.1	-2.0	-2.5	-2.9	-1.8
Birth weight of first child	4.3	7.9	8.9	2.9	3.0	2.5	3.0	2.5	2.9
Cholesterol lowering medication	4.3	6.4	7.9	2.8	2.5	2.1	2.4	2.7	2.6
Medication: Levothyroxine sodium	4.1	7.0	9.8	2.1	2.0	3.1	3.1	2.4	2.9
Pulse rate, automated reading	3.8	12.3	21.1	-4.6	-4.0	-2.5	-3.1	-3.8	-2.5
Financial difficulties in last 2 years	3.7	4.9	7.8	1.7	2.4	1.6	2.2	2.8	2.4
Age when periods started (menarche)	3.5	8.5	10.4	-2.7	-2.9	-2.8	-2.8	-3.2	-3.2
Had menopause	3.5	4.3	6.5	2.3	2.2	1.9	1.9	2.5	1.3
Illness, injury, bereavement, stress in last 2 years	3.4	4.1	5.5	-2.4	-1.7	-1.9	-2.3	-1.6	-2.2
Fasting Glucose	3.3	3.9	5.4	2.0	2.3	1.3	2.3	1.3	2.3
Medication: Amlodipine	3.2	4.5	6.6	-1.6	-2.2	-2.6	-1.8	-2.6	-1.7
Length of working week for main job	3.0	3.3	10.2	-3.2	-1.5	-1.5	-1.3	-1.7	-0.8
Vitamin and mineral supplements	2.9	4.0	5.1	-1.8	-2.3	-1.4	-2.2	-2.1	-2.0
Father’s age at death	2.9	3.9	6.4	2.5	2.1	1.9	1.6	2.1	1.3
Number of treatments/medications taken	2.8	5.1	10.0	1.2	2.0	1.8	2.7	2.1	3.2
Medication: Simvastatin	2.8	4.2	6.3	2.3	1.7	1.7	2.2	1.7	2.5
Birth weight	2.8	6.2	9.5	2.2	1.9	2.5	2.6	2.4	3.1
Trunk predicted mass	2.7	15.6	27.0	2.7	3.9	5.2	4.0	4.0	3.5
Arm predicted mass (left)	2.7	13.6	24.1	2.1	3.7	4.9	3.7	3.8	3.4
Depressed Affect (Nagel 2018)	2.6	5.5	8.2	2.5	2.3	1.9	2.0	2.9	2.3
Trunk fat-free mass	2.6	15.0	26.1	2.6	3.8	5.1	3.9	4.0	3.5
Type 2 Diabetes (T2D) (2012)	2.5	2.9	4.4	0.9	1.6	1.9	2.0	1.5	2.1
Height	2.5	48.5	65.1	6.2	7.2	8.1	7.4	7.0	5.8
Comparative body size at age 10	2.5	6.9	10.4	1.4	2.6	2.8	2.8	2.6	3.2
Prospective memory result	2.4	2.9	4.0	1.7	2.0	1.7	1.8	1.2	1.7
Arm fat-free mass (right)	2.4	12.1	22.8	2.0	3.4	4.8	3.4	3.7	3.1
Arm predicted mass (right)	2.4	12.4	24.1	1.9	3.4	4.9	3.4	3.7	3.2
Depression (Nagel 2018)	2.3	3.5	4.9	2.1	2.2	1.2	1.8	2.0	1.7
Ever taken oral contraceptive pill	2.3	2.5	3.6	-1.0	-1.8	-1.8	-1.2	-1.9	-1.6
Schizophrenia vs Biploar Disorder	2.2	2.9	4.5	-1.0	-1.2	-2.1	-2.1	-1.5	-1.9
Qualifications: A levels/AS levels or equivalent	2.2	4.8	6.8	-1.2	-1.9	-2.6	-2.0	-2.5	-2.6
Number of full sisters	2.2	2.7	4.0	-1.0	-1.7	-1.6	-1.8	-1.6	-2.0
Supplements: Calcium	2.2	2.4	4.3	1.3	2.1	1.6	1.9	1.0	1.2
Lupus	2.1	3.2	4.6	1.0	2.2	1.8	2.1	1.9	1.5
Schizophrenia (2014)	2.1	4.7	8.6	-1.9	-1.9	-2.2	-2.9	-1.7	-2.2
Average weekly fortified wine intake	2.1	2.4	4.3	-1.4	-1.6	-1.7	-1.1	-2.1	-1.3
Weight	2.1	10.5	21.3	0.8	3.1	4.6	3.0	3.3	3.4
Whole body fat-free mass	2.1	11.9	22.3	1.9	3.4	4.7	3.4	3.5	3.2
Osteoarthritis (self-reported)	2.1	2.7	5.3	0.8	1.7	2.3	1.5	2.0	1.2
Whole body water mass	2.1	12.0	22.2	2.0	3.4	4.7	3.3	3.6	3.2
Basal metabolic rate	2.1	11.4	22.2	1.7	3.3	4.7	3.3	3.4	3.2
Arm fat-free mass (left)	2.1	10.7	19.2	1.9	3.2	4.4	3.3	3.4	2.9
Number of operations (self-reported)	2.1	3.2	6.6	2.3	1.0	0.7	1.8	1.5	2.6
Ever depressed for a whole week	2.1	2.6	4.3	1.6	2.1	0.9	1.7	1.7	1.4
Knee pain experienced in last month	2.0	3.1	5.4	1.3	2.1	1.3	1.4	2.3	1.7
Eye problems/disorders: Cataract	2.0	2.3	3.3	-1.4	-1.6	-0.9	-1.8	-1.7	-1.5
High cholesterol (Self-reported)	2.0	3.6	5.8	2.3	1.9	1.3	1.3	2.4	1.9
Ever used hormone-replacement therapy (HRT)	1.9	2.4	4.3	1.2	2.1	1.4	1.9	1.4	1.3
Standing height	1.9	19.2	34.0	4.0	4.2	5.8	4.7	4.1	2.9
Townsend deprivation index at recruitment	1.8	2.6	3.8	-1.5	-1.7	-1.1	-1.9	-1.4	-2.0
Medication for pain relief, constipation, heartburn	1.8	3.0	5.8	-0.8	-1.4	-2.0	-1.0	-2.1	-2.4
Leg pain on walking	1.8	2.2	3.9	2.0	1.5	1.2	1.1	1.6	1.4
Illnesses of father: High blood pressure	1.8	2.3	4.1	-1.2	-1.8	-1.6	-2.0	-1.1	-1.1
HDL Cholesterol	1.7	2.8	4.8	-1.7	-1.6	-1.6	-2.2	-1.2	-1.7
Illnesses of mother	1.7	2.1	5.2	-2.3	-1.2	-0.3	-1.3	-1.9	-1.0
Ever had bowel cancer screening	1.7	2.0	2.9	1.3	1.7	0.9	1.2	1.5	1.6
Medication: Gliclazide	1.7	1.9	4.4	1.6	1.4	0.7	2.1	0.6	1.3
Mother’s age at death	1.7	2.1	2.7	1.4	1.1	1.5	1.6	1.4	1.6
Ever had hysterectomy (womb removed)	1.6	1.8	3.2	-0.9	-1.8	-1.1	-1.4	-1.6	-1.1
Trunk fat mass	1.6	6.7	14.4	0.0	2.4	3.8	2.2	2.6	2.9
Time employed in main current job	1.6	1.8	3.3	-1.7	-0.9	-0.7	-1.8	-0.8	-1.6
Chronic bronchitis/emphysema (mother)	1.6	1.8	5.5	-2.4	-1.5	-0.4	-1.0	-1.0	-1.0
Shortness of breath walking on level ground	1.6	1.9	3.6	-1.9	-1.4	-0.2	-1.4	-1.6	-1.1
Whole body fat mass	1.6	6.9	14.5	-0.1	2.4	3.8	2.2	2.7	3.0
Long-standing illness, disability or infirmity	1.6	2.5	4.9	2.2	1.0	0.9	1.5	1.4	2.0
LDL Cholesterol	1.5	2.4	4.0	-2.0	-1.7	-0.5	-1.6	-1.6	-1.6
Leg predicted mass (left)	1.5	7.7	15.4	1.2	2.7	3.9	2.5	2.8	2.8
Average weekly champagne plus white wine intake	1.5	2.0	4.4	0.6	1.2	1.4	2.1	0.6	1.9
Ovarian Cancer	1.4	1.9	3.0	-1.7	-1.2	-1.5	-1.3	-1.4	-1.2
Hearing difficulty/problems: Yes	1.4	2.1	4.5	1.3	1.6	0.9	1.0	2.1	1.5
Serious illness, injury or assault to yourself	1.4	1.7	3.4	-0.9	-1.8	-1.3	-1.2	-1.2	-1.2
Diastolic blood pressure, automated reading	1.4	4.4	9.8	-1.2	-1.7	-3.1	-2.5	-1.7	-1.8
Leg fat mass (left)	1.4	5.3	11.5	-0.5	1.9	3.4	1.9	2.2	2.8
Schizophrenia (2018)	1.3	2.6	5.7	-0.9	-1.1	-1.9	-2.4	-0.8	-1.9
Leg fat-free mass (left)	1.3	7.0	14.3	1.1	2.5	3.8	2.4	2.7	2.7
Pain all over the body in last month	1.3	1.4	3.1	0.1	1.4	1.1	1.8	0.8	1.3
Hair/balding pattern: Pattern 3	1.3	2.0	3.0	1.7	1.0	1.2	1.6	1.5	1.3
Number of live births	1.3	1.9	3.1	-1.4	-1.8	-0.8	-1.3	-1.7	-1.0
Arm fat mass (right)	1.3	5.2	10.6	-0.6	2.0	3.3	1.9	2.2	2.8
Heart disease (mother)	1.3	1.5	4.6	2.1	0.7	0.3	1.1	1.4	0.8
Leg fat mass (right)	1.3	5.2	10.7	-0.3	2.0	3.3	1.9	2.2	2.8
Leg predicted mass (right)	1.3	6.9	14.7	1.1	2.5	3.8	2.4	2.6	2.6
Myopia	1.3	2.0	4.1	-0.6	-1.5	-1.3	-2.0	-0.8	-1.6
Pain experienced in last month	1.3	2.1	4.0	-1.2	-1.5	-0.6	-1.5	-1.5	-2.0
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.9	-1.0	-0.8	-1.7	-0.7	-1.3	-1.0
Blood clot in the leg (DVT)	1.2	1.6	4.6	0.7	1.5	0.8	0.4	2.1	1.2
Medication: Paracetamol	1.2	1.9	6.0	0.1	0.7	1.5	1.4	0.8	2.4
Leg fat-free mass (right)	1.2	6.6	13.9	1.1	2.4	3.7	2.3	2.6	2.6
Friendships satisfaction	1.2	1.5	2.6	-1.1	-1.4	-1.2	-1.6	-0.9	-1.2
Arm fat mass (left)	1.2	5.1	10.8	-0.5	2.1	3.3	1.8	2.2	2.6
Prostate Cancer	1.1	1.5	3.3	1.4	1.8	-0.1	0.3	1.8	0.4
Mood swings	1.1	2.1	4.2	2.0	1.0	0.4	0.9	1.9	1.6
Average weekly spirits intake	1.0	1.2	2.2	-1.0	0.8	1.5	1.2	0.4	1.3
Hip circumference	1.0	4.4	10.3	-0.2	2.0	3.2	1.4	2.4	2.1
Breastfed as a baby	1.0	1.2	3.0	-0.1	-0.5	-1.5	-1.2	-0.7	-1.7
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.7	-1.6	-1.5	-0.8	-0.8	-1.2	0.1
Leg fat percentage (right)	1.0	3.7	6.6	-0.5	1.7	2.6	1.6	2.0	2.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.7	1.9	0.8	0.7	0.7	1.0	1.0
Overall health rating	1.0	2.1	4.2	-1.2	-2.0	-1.4	-1.6	-1.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.6	0.6	1.2	0.5	1.7	0.9	1.9
Eye problems/disorders: Glaucoma	1.0	1.2	5.2	2.3	0.5	-0.1	1.0	0.7	0.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.8	0.5	1.4	0.8	0.4	1.9	1.1
Medication: Co-codamol	0.9	1.0	2.8	0.1	1.2	0.3	1.2	0.6	1.7
Relative age voice broke	0.9	1.3	2.8	0.2	1.1	1.3	0.8	1.7	1.3
Hearing difficulty/problems with background noise	0.9	1.5	4.6	1.0	1.0	0.3	0.8	2.1	1.3
Asthma	0.9	1.7	3.8	-1.1	-1.4	-1.5	-0.8	-2.0	-0.3
Medication: Cholesterol lowering	0.9	1.3	3.0	1.1	0.9	0.5	1.5	0.7	1.7
Lung cancer (father)	0.9	1.0	2.3	0.1	1.0	1.2	0.8	1.5	1.0
Medication: Ibuprofen	0.9	1.1	2.4	0.5	0.3	1.6	0.4	1.4	1.4
Family relationship satisfaction	0.9	1.1	3.7	-1.9	-0.9	-0.7	-0.8	-0.7	-0.6
Average weekly red wine intake	0.9	1.3	3.3	1.2	1.5	0.7	0.3	1.8	0.3
Osteoporosis (self-reported)	0.9	1.1	2.7	1.4	0.7	1.2	0.1	1.7	-0.0
Medication: Paracetamol	0.9	1.4	4.6	0.6	0.7	1.1	1.3	0.5	2.1
Alcohol drinker status: Never	0.9	1.0	3.2	-1.8	-1.0	-0.4	-0.9	-0.9	0.5
Leg fat percentage (left)	0.9	3.3	6.4	-0.8	1.5	2.5	1.4	1.9	2.4
Basal cell carcinoma (self-reported)	0.9	1.0	1.4	0.7	1.1	1.0	1.2	1.1	1.0
Coronary Artery Disease (CAD)	0.8	1.0	2.0	1.4	1.1	-0.2	1.1	0.6	1.1
Neuroticism (2016)	0.8	1.2	1.8	1.2	0.8	1.4	0.7	1.3	1.0
Blood Platelet Count	0.8	9.7	17.1	-2.9	-3.1	-3.8	-1.9	-4.1	-2.1
Systolic Blood Pressure	0.8	3.8	11.3	-0.5	-1.6	-3.4	-1.6	-2.2	-1.2
Supplements: Zinc	0.8	0.9	1.6	1.2	1.3	0.9	0.7	1.0	0.4
Trunk fat percentage	0.8	3.4	7.3	-0.6	1.6	2.7	1.4	1.8	2.2
Age at last live birth	0.8	1.1	2.0	-0.4	-1.2	-0.8	-1.3	-0.9	-1.4
Illnesses of father: None of the above (group 1)	0.8	1.0	2.2	-1.5	-0.6	-1.0	-0.5	-1.4	-0.4
Financial situation satisfaction	0.8	0.9	1.3	-0.7	-1.0	-1.1	-0.9	-1.0	-1.0
Commuting to job workplace: Public transport	0.8	1.0	1.8	0.4	1.1	1.4	0.8	1.2	0.7
Irritability	0.8	1.4	4.5	-2.1	-0.7	-1.6	-0.8	-0.7	0.1
Bipolar Disorder or Schizophrenia	0.7	1.7	4.3	-1.2	-1.0	-1.1	-2.1	-0.4	-1.4
Current tobacco smoking	0.7	1.1	4.5	-2.1	-1.1	0.2	-0.8	-0.5	-0.5
High blood pressure	0.7	2.0	3.9	-0.9	-1.6	-1.8	-1.0	-2.0	-0.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	0.5	1.2	1.3	0.5	1.0	0.4
Sitting height	0.7	4.8	10.5	1.4	2.1	3.2	2.8	1.3	1.4
Body mass index (BMI)	0.7	3.0	5.5	-1.0	1.4	2.3	1.1	1.7	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.8	1.3	1.7	-0.0	1.5	1.1	1.2
Pulse wave reflection index	0.7	0.8	3.5	1.9	0.5	0.1	0.8	0.4	0.6
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.3	-0.9	-1.1	-1.2	-0.7	-1.1	-0.0
Body fat percentage	0.7	2.8	6.0	-0.9	1.3	2.5	1.1	1.7	2.1
Worry too long after embarrassment	0.7	1.2	2.2	1.0	0.9	0.6	1.5	0.7	1.4
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.9	1.4	0.6	0.9	0.9	0.8	0.6
Medication: Blood pressure	0.7	1.3	2.9	-1.6	-1.0	-0.4	-0.7	-1.7	-0.5
Asthma (self-reported)	0.7	1.3	3.4	-1.0	-1.2	-1.4	-0.4	-1.8	0.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.9	1.4	0.8	0.4	0.8	0.5	1.1
Body Mass Index (BMI) (2010)	0.6	0.8	1.4	0.2	0.9	1.2	1.1	0.8	0.8
Mean Putamen Volume	0.6	0.7	1.0	-0.1	0.9	1.0	0.8	0.8	0.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.7	1.3	1.2	0.4	0.5	1.1	0.4
Relative age of first facial hair	0.6	1.2	2.4	0.4	1.5	1.2	0.7	1.6	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	0.9	1.3	0.6	0.6	1.0	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.2	1.2	1.4	0.2	1.5	1.1	1.2
Qualifications: CSEs or equivalent	0.6	0.8	1.8	-0.4	-1.3	-1.1	-0.6	-1.0	-0.7
Nervous feelings	0.6	1.1	2.0	-0.8	-1.4	-1.2	-0.8	-1.1	-0.5
Impedance of arm (right)	0.6	2.7	4.4	-0.5	-1.7	-2.0	-1.3	-2.1	-1.7
Happiness	0.6	0.7	2.9	-1.7	-0.2	-0.6	-0.8	-0.4	-0.7
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.2	-1.0	-1.0	-0.9	-0.9	-0.8	-1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.9	0.5	0.8	1.3	1.2	1.4	1.2
Number of full brothers	0.6	0.7	1.3	-0.9	-1.1	-0.1	-1.1	-0.7	-0.8
Medication: Omeprazole	0.6	0.8	1.2	-0.3	0.8	0.9	1.0	0.9	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.5	-0.7	-0.3	-1.2	-0.8	-0.3	-1.0
Medication for cholesterol	0.6	0.9	1.3	-1.1	-0.8	-0.5	-1.0	-0.9	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	0.2	1.0	0.9	0.4	1.1	0.8
Medication: Blood pressure	0.6	1.1	1.9	1.3	0.9	0.1	1.4	0.5	1.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.2	0.6	0.8	1.5	0.5	0.9	0.6
Ever smoked	0.6	1.1	2.0	-0.6	-1.3	-0.4	-1.1	-0.9	-1.4
Risk taking	0.6	0.8	4.3	-2.1	-0.5	0.3	-0.5	-0.2	-0.3
Alzheimer’s Disease (in father)	0.5	0.5	1.3	-0.2	0.7	0.7	0.6	1.1	0.7
Triglycerides	0.5	0.8	2.1	-1.0	-0.8	-0.9	0.2	-1.5	0.3
Sensitivity / hurt feelings	0.5	0.9	1.7	-0.0	-1.0	-1.3	-1.2	-0.5	-1.1
Maternal smoking around birth	0.5	0.7	1.4	0.8	0.7	1.0	0.6	1.2	0.5
Taking other prescription medications	0.5	0.8	1.4	0.9	1.1	-0.2	1.0	0.6	1.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.0	-1.0	-0.9	-1.4	-0.1	-1.7	-0.2
High blood pressure (mother)	0.5	0.7	1.6	1.2	-0.2	-1.3	-0.6	0.2	-0.9
Fluid intelligence score	0.5	1.0	3.8	1.9	1.0	-0.2	0.8	0.9	0.0
Illnesses of siblings	0.5	0.7	1.6	-1.3	-0.4	0.1	-0.4	-1.1	-1.0
Worrier / anxious feelings	0.5	1.0	3.9	0.5	0.5	0.6	-0.1	2.0	1.2
Impedance of arm (left)	0.5	2.1	3.1	-0.5	-1.4	-1.5	-1.3	-1.8	-1.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.2	0.2	0.1	0.5	1.1	0.5	1.5
Age at first live birth	0.5	0.9	2.5	-1.6	-0.4	-0.5	-0.9	-0.9	-0.9
Mean time to correctly identify matches	0.5	0.9	2.1	1.4	1.2	-0.2	1.0	0.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.4	-1.2	-0.5	-0.9	-0.9	-0.4	-0.4
Arm fat percentage (left)	0.5	2.1	3.8	-1.5	1.0	2.0	0.7	1.2	1.8
Smoking status: Current	0.5	0.9	3.5	-1.9	-1.0	0.5	-0.6	-0.3	-0.2
Medication: Atorvastatin	0.5	0.6	1.0	0.9	0.8	0.1	0.8	1.0	0.7
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.7	0.4	1.3	1.6	0.8	1.6	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	-0.8	0.6	0.7	0.7	0.9	0.9
Heart disease (siblings)	0.5	0.6	1.7	-0.4	-1.0	-1.3	-0.5	-0.8	-0.4
Neuroticism (Nagel 2018)	0.4	1.0	1.8	1.1	0.7	0.5	0.7	1.3	1.3
Lung FVC	0.4	1.8	3.7	-0.5	-1.3	-0.8	-1.9	-1.1	-1.8
Medication: Metformin	0.4	0.6	1.6	0.2	0.4	0.5	1.1	-0.0	1.3
Fed-up feelings	0.4	0.7	2.1	0.3	1.1	0.5	0.0	1.4	0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	0.4	0.4	0.7	1.1	-0.0	0.9
Waist circumference	0.4	1.5	3.4	-1.1	0.6	1.9	0.6	1.0	1.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.8	0.4	0.8	0.9	0.7	0.4	0.7
Heart attack	0.4	0.5	1.4	-0.2	-0.7	-0.6	-0.7	-0.5	-1.2
Arm fat percentage (right)	0.4	1.8	3.3	-1.6	0.8	1.7	0.6	1.0	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.5	-0.4	-0.4	1.2	-0.3	0.9	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.3	-0.7	-0.9	-0.8	-1.4	-0.8	-1.8
Peak expiratory flow (PEF)	0.4	0.9	2.1	-0.1	-0.8	-1.0	-1.1	-0.5	-1.4
Loud music exposure frequency	0.4	0.4	1.5	-1.2	-0.6	0.6	0.2	0.1	0.6
Glaucoma (self-reported)	0.4	0.4	1.8	1.4	-0.4	-0.6	0.2	-0.1	-0.4
Pulse wave peak to peak time	0.4	0.5	1.1	0.3	0.9	0.7	0.5	1.0	0.1
Qualifications: College or University degree	0.4	1.2	3.7	-1.2	-0.6	0.1	-0.9	-1.1	-1.9
Medication: Allopurinol	0.4	0.5	1.5	-0.1	0.2	0.9	1.2	-0.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	0.0	-0.7	-1.0	-0.7	-0.4	-1.0
Suffer from ‘nerves’	0.4	0.6	0.8	0.9	0.9	0.6	0.4	0.9	0.8
Smoking status: Previous	0.4	0.6	1.2	1.1	0.5	0.8	0.6	0.7	0.6
Wears glasses or contact lenses	0.4	0.4	1.3	-1.1	-0.1	0.2	0.6	-0.6	0.6
Average weekly beer plus cider intake	0.4	0.5	1.6	-0.0	0.4	-0.1	-0.0	1.1	1.3
Unable to work because of sickness or disability	0.4	0.5	2.2	1.5	0.2	0.2	0.3	0.4	0.6
Impedance of whole body	0.4	2.2	3.6	-0.4	-1.5	-1.6	-1.2	-1.8	-1.9
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.2	1.1	1.0	0.6	0.8	0.9	0.0
Breast Cancer	0.3	0.8	1.7	-0.9	0.7	-0.3	1.2	-0.5	1.3
Blood Eosinophil Count	0.3	2.3	6.6	-2.6	-1.2	0.9	0.4	-2.0	1.0
Allergy or Eczema	0.3	0.8	2.6	-0.5	-0.5	-1.1	0.4	-1.6	0.2
Respiratory disease	0.3	0.7	2.2	-0.7	-0.7	-1.0	-0.3	-1.5	-0.1
Hand grip strength (left)	0.3	0.8	1.1	0.9	1.1	1.0	0.7	1.0	0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.1	1.4	-0.2	-0.0	0.5	-0.4	0.0
Impedance of leg (right)	0.3	1.4	2.7	-0.0	-1.1	-1.5	-0.8	-1.3	-1.6
Multivitamins +/- minerals	0.3	0.4	0.7	0.4	0.6	0.8	0.7	0.8	0.6
Medication: Atenolol	0.3	0.4	0.9	0.6	0.2	0.9	0.5	1.0	0.4
Impedance of leg (left)	0.3	1.6	3.1	-0.1	-1.3	-1.3	-0.9	-1.4	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	0.8	0.5	-0.1	0.5	0.8	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.7	0.8	0.7	0.4	0.8	0.8	0.8
Tense / ‘highly strung’	0.3	0.5	1.4	-0.5	-0.3	-1.1	-0.2	-1.2	0.3
Headache pain in last month	0.3	0.6	1.5	-0.1	-0.7	-1.2	-1.0	-0.3	-0.6
High blood pressure (siblings)	0.3	0.4	1.7	0.2	-0.2	-1.3	-0.8	0.1	0.0
Exposure to tobacco smoke outside home	0.3	0.3	0.8	-0.5	-0.0	-0.4	-0.7	0.9	-0.6
Health satisfaction	0.3	0.3	0.7	-0.5	-0.8	0.2	-0.6	-0.7	-0.4
Supplements: Vitamin C	0.3	0.3	0.8	0.5	0.9	-0.1	0.6	0.3	0.7
Hypertension (Self-reported)	0.3	1.0	2.5	-0.3	-1.0	-1.3	-0.5	-1.6	-0.4
Number of self-reported non-cancer illnesses	0.3	0.4	1.4	0.5	0.2	0.1	1.0	0.3	1.2
Miserableness	0.3	0.5	1.1	-0.5	-0.6	-1.1	-1.0	0.1	-0.2
Medication: Lisinopril	0.3	0.4	1.1	-0.1	-0.7	-0.8	-0.2	-1.1	-0.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	-0.6	0.1	0.5	0.7	0.4	0.8
Age started oral contraceptive pill	0.3	0.4	1.4	-0.3	1.2	0.1	0.6	0.6	0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	-0.1	-0.6	-0.5	-0.7	-0.4	-1.1
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.6	1.6	1.0	0.0	0.6	0.8	0.2
Major Depression (MDD)	0.2	0.3	0.6	-0.0	-0.6	-0.6	-0.3	-0.8	-0.4
Rheumatoid Arthritis	0.2	0.3	0.6	-0.7	0.3	-0.8	-0.4	-0.3	-0.3
Blood Red Count	0.2	1.7	3.3	0.9	1.8	0.4	1.7	0.8	1.6
Blood White Count	0.2	1.3	3.7	-1.2	-1.1	-1.3	-0.0	-1.9	0.1
BMI	0.2	1.4	2.9	-1.5	0.8	1.2	0.3	1.0	1.7
Smoking Status	0.2	0.5	1.6	-0.5	0.2	1.3	0.5	0.8	0.6
Hypothyroidism (self reported)	0.2	0.4	1.5	-0.2	-0.2	1.2	0.5	0.6	0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.1	0.9	0.1	0.3	1.0	0.1	0.9
Lung FEV1/FVC ratio	0.2	1.2	2.6	-0.9	-1.6	-0.5	-0.4	-1.5	-1.0
Systolic blood pressure, automated reading	0.2	0.5	1.3	1.0	0.7	-1.2	-0.0	0.4	0.3
Hand grip strength (right)	0.2	0.5	1.4	0.4	0.8	1.2	0.7	0.4	-0.0
Stomach or abdominal pain in last month	0.2	0.2	0.6	-0.4	-0.3	-0.7	-0.2	-0.6	0.3
Allergy	0.2	0.4	1.2	0.5	0.0	1.1	-0.3	0.9	-0.5
Diabetes (self-reported)	0.2	0.3	0.7	0.0	0.2	0.2	0.9	-0.2	0.8
Noisy workplace	0.2	0.2	0.5	0.7	0.4	-0.2	-0.1	0.5	0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.6	-0.8	0.6	0.0	-0.0	-0.7
Medication: Lansoprazole	0.2	0.2	0.7	-0.5	0.0	0.2	-0.3	0.8	0.6
Pulse wave Arterial Stiffness index	0.2	0.3	0.7	-0.0	-0.8	-0.4	-0.3	-0.8	-0.0
Gout (self-reported)	0.2	0.3	0.8	-0.9	0.0	0.2	0.6	-0.2	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	0.5	1.0	-0.3	0.3	0.2	0.5
Number of children fathered	0.2	0.3	0.7	0.8	0.4	-0.1	0.8	-0.2	0.2
Eye problems/disorders: None of the above	0.2	0.3	1.2	-1.1	0.1	-0.1	0.1	-0.3	0.5
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.8	0.4	0.3	0.3	0.1	-0.2
Had major operations	0.2	0.3	0.9	0.6	-0.4	-1.0	-0.3	0.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.9	-0.3	-0.2	-0.7	0.1	0.5	0.9
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.5	-0.6	-0.6	-0.7	-0.3	0.0
Diabetes diagnosed by doctor	0.2	0.4	1.0	0.3	0.1	-0.3	1.0	-0.4	1.0
Back pain experienced in last month	0.2	0.3	0.4	0.5	0.3	0.6	0.3	0.6	0.6
Medication: Aspirin	0.2	0.2	1.0	1.0	0.2	0.2	-0.2	0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.1	0.1	0.6	1.0	0.2	0.7	0.1
Guilty feelings	0.2	0.2	1.0	0.3	-0.3	-1.0	-0.3	0.3	-0.2
Hearing aid user	0.2	0.3	0.5	-0.6	-0.2	-0.6	-0.1	-0.5	0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.2	0.6	0.6	0.5	0.7	0.2
Bipolar Disorder (2018)	0.1	0.2	0.6	-0.7	-0.2	0.8	-0.3	0.4	0.1
Worry (Nagel 2018)	0.1	0.1	0.5	-0.2	-0.4	-0.2	-0.2	-0.3	0.7
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.2	-0.2	-0.1	0.3	-0.6	-0.0
Crohns Disease (2017)	0.1	0.2	0.4	0.6	0.6	0.5	0.6	-0.1	0.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	0.3	0.8	0.6	0.7	-0.3	0.0
Ulcerative Colitis (UC)	0.1	0.3	0.8	0.3	0.9	0.5	0.7	-0.1	0.1
Reaction Time	0.1	0.2	0.8	0.6	-0.0	-0.9	-0.1	-0.4	0.0
Crohns Disease (2012)	0.1	0.1	0.4	-0.3	-0.1	0.3	-0.0	-0.7	-0.5
HbA1C	0.1	0.1	0.2	-0.4	0.0	-0.1	-0.2	-0.2	-0.3
Ulcerative Colitis	0.1	0.1	0.5	0.1	0.7	-0.0	0.3	0.1	0.1
Waist Hip Ratio (WHR)	0.1	0.5	1.5	-0.5	-1.0	-1.2	-0.3	-0.7	-0.0
Cardiovascular Disease	0.1	0.4	1.2	-0.2	-0.2	-1.1	-1.0	0.0	0.0
Neuroticism	0.1	0.1	0.5	0.0	0.1	0.1	-0.1	0.7	0.6
Chronotype (morning person)	0.1	0.3	1.7	-1.3	-0.2	-0.0	-0.3	-0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.6	-0.1	-0.8	0.1	-0.2	0.1	0.2
Angina	0.1	0.2	0.6	0.1	-0.8	-0.3	-0.6	-0.2	-0.1
Severe depression (siblings)	0.1	0.2	0.4	-0.1	-0.2	-0.3	-0.7	0.1	-0.6
Pack years adult smoking proportion	0.1	0.2	0.5	-0.4	-0.5	-0.4	-0.7	-0.4	-0.2
Past tobacco smoking	0.1	0.1	0.4	0.3	0.6	-0.4	0.3	0.2	0.3
Alcohol usually taken with meals	0.1	0.2	0.4	0.5	-0.4	-0.6	0.1	-0.5	-0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	-0.1	0.6	-0.2	-0.3	0.4	0.2
Had other major operations	0.1	0.1	0.3	-0.1	0.1	0.2	-0.0	-0.1	0.5
Forced vital capacity (FVC)	0.1	0.4	1.3	0.3	0.5	1.1	0.0	0.8	-0.4
Qualifications: None of the above	0.1	0.2	0.8	0.1	0.7	0.2	0.4	0.1	0.9
Mouth/teeth dental problems	0.1	0.1	0.3	0.0	0.6	-0.1	-0.4	0.1	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.3	-0.1	-0.2	0.7	-0.2	0.7
Medication: Ramipril	0.1	0.1	0.2	0.2	-0.4	-0.2	0.1	-0.2	0.3
Neuroticism score	0.1	0.2	0.7	0.1	0.0	-0.3	-0.1	0.4	0.9
Alcohol intake versus 10 years previously	0.1	0.2	0.6	-0.2	-0.6	-0.5	-0.8	-0.1	-0.1
Falls in the last year	0.1	0.2	0.6	-0.0	-0.5	-0.8	0.1	0.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.9	0.0	-0.1	0.5	-0.4	0.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.3	0.1	-0.5	-0.6	-0.3	-0.4	-0.2
Depression (self-reported)	0.1	0.1	0.2	0.4	0.4	0.1	-0.2	0.5	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.6	-0.1	-0.3	0.2	0.0	0.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.1	0.7	0.1	0.5	0.6	0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	0.4	0.0	0.2	-0.1	0.5	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.4	1.5	-0.7	-0.2	0.1	-0.8	-0.3	-1.2
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	-0.5	0.2	-0.2	0.2	-0.6	0.3
Neck or shoulder pain in last month	0.1	0.2	0.4	0.3	-0.6	-0.6	-0.3	-0.3	0.4
Angina (self-reported)	0.1	0.1	0.2	0.5	-0.3	-0.0	-0.1	0.1	0.4
Migraine (self-reported)	0.1	0.1	0.4	-0.6	-0.1	0.1	0.0	0.1	0.6
Medication: Seretide 50 evohaler	0.1	0.2	0.5	0.7	-0.2	-0.3	0.4	0.3	0.2
Alcohol intake frequency.	0.1	0.3	1.1	-0.4	-0.4	-0.1	0.1	-0.5	1.1
Chest pain or discomfort	0.1	0.1	0.2	0.4	-0.1	-0.2	0.0	0.1	-0.4
Medication: Aspirin	0.1	0.2	0.7	0.8	0.4	0.2	0.0	0.4	-0.0
Illnesses of father: Heart disease	0.1	0.2	0.4	0.6	0.3	0.7	0.3	0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.3	-0.2	-0.3	0.6	-0.2	0.0	-0.6
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.1	-0.1	-0.4	-0.1	0.5	-0.0
Loneliness, isolation	0.1	0.1	0.4	-0.6	0.4	-0.1	-0.1	0.2	0.4
Qualifications: nursing, teaching	0.1	0.2	0.5	0.2	0.7	0.1	0.7	-0.2	0.4
Breast cancer (self-reported)	0.1	0.1	0.5	0.7	0.1	0.0	0.3	0.3	-0.3
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.0	0.5	0.4	-0.1	0.5	0.1
Commuting to job workplace: Cycle	0.1	0.1	0.4	0.4	0.5	0.3	0.0	0.6	0.2
Alcohol drinker status: Previous	0.1	0.1	0.7	0.8	-0.0	0.1	-0.0	0.3	-0.2
Alzheimer’s Disease (including proxy)	0.0	0.1	0.2	-0.5	0.2	-0.0	0.2	-0.1	0.3
Age at First Birth	0.0	0.0	0.1	0.3	0.2	0.2	0.2	-0.0	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.1	0.3	0.1	-0.2	-0.2	-0.0	0.1
Heel T-Score	0.0	0.2	0.5	-0.3	0.6	-0.7	0.5	0.2	0.5
Hair Pigment	0.0	0.6	2.3	0.3	0.4	0.9	-0.4	1.5	0.2
Tanning	0.0	0.6	2.1	-1.5	0.4	0.3	0.3	-0.9	0.1
Medication for hormone replacement therapy	0.0	0.1	0.2	-0.1	-0.2	-0.5	0.0	-0.2	-0.1
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.3	0.1	-0.2	0.1	-0.3	-0.1
Commuting to job workplace: Walk	0.0	0.0	0.1	0.1	-0.3	-0.0	-0.3	-0.0	-0.1
Pack years of smoking	0.0	0.0	0.1	0.2	-0.0	0.1	-0.3	0.1	0.0

Hub : Genes

FBXO17

Models

Trait associations