Hub : Genes

FBXO31

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.2134 0.0527 7.2e-07 0.050 NA 0.113 NA 0.099 1.8e-04 NA 2.4e-08 NA 1.8e-07
2 GTEx Skin Sun Exposed Lower leg 0.0800 0.0310 2.9e-03 0.092 NA 0.078 NA 0.079 4.8e-08 NA 4.8e-07 NA 4.0e-07
3 GTEx Testis 0.2140 0.0760 3.2e-03 0.088 NA 0.124 NA 0.120 9.9e-05 NA 3.9e-06 NA 5.4e-06
4 GTEx Thyroid 0.1670 0.0460 6.4e-05 0.020 NA 0.051 NA 0.040 1.1e-02 NA 9.2e-05 NA 4.7e-04
5 METSIM Adipose 0.0723 0.0194 2.3e-07 0.031 0.055 0.058 0.069 0.072 1.6e-05 1.2e-08 4.1e-09 1.3e-10 6.0e-11
6 TCGA Rectum Adenocarcinoma 0.3740 0.1370 6.0e-03 -0.007 -0.005 -0.013 NA -0.011 5.1e-01 4.5e-01 1.0e+00 NA 7.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 3.2 5.0 15.6 1.6 2.2 -4.0 1.7 2.1 -0.2
Bipolar Disorder or Schizophrenia 1.6 3.9 14.5 0.6 1.6 -3.8 0.4 2.0 -1.3
Depressed Affect (Nagel 2018) 5.1 10.8 19.8 2.8 4.5 -1.8 4.0 4.0 1.2
Depression (Nagel 2018) 3.2 4.8 9.2 1.7 2.3 -2.4 3.0 2.2 1.1
Intelligence (Savage-Jansen 2018) 3.8 11.6 25.2 -2.6 -5.0 2.8 -2.7 -4.2 -2.3
Neuroticism (Nagel 2018) 7.5 17.7 30.1 3.1 5.5 -4.5 4.5 4.5 2.4
Schizophrenia (2018) 0.6 1.2 3.0 -0.5 0.2 -1.7 -0.9 0.9 -1.5
Schizophrenia vs Biploar Disorder 0.6 0.8 2.3 -1.5 0.5 -0.1 -1.1 0.5 0.9
Worry (Nagel 2018) 4.9 10.3 20.5 1.4 4.0 -4.5 3.0 3.1 2.1
Alzheimer’s Disease (in mother) 0.7 0.8 2.6 -0.3 0.8 1.1 -0.5 1.6 0.2
Alzheimer’s Disease (in father) 0.2 0.2 0.6 0.8 -0.3 0.1 0.5 -0.0 0.2
Alzheimer’s Disease (including proxy) 1.2 1.7 4.4 1.4 1.4 0.7 1.1 2.1 0.8
Crohns Disease (2017) 0.6 1.3 6.6 -0.7 -0.5 0.4 -0.2 -2.6 0.7
Irritable Bowel Disease (IBD) 0.7 1.7 6.3 -0.4 -0.5 0.0 -0.4 -2.5 1.8
Ulcerative Colitis (UC) 1.0 1.9 7.8 0.3 0.5 -0.8 -0.3 -1.5 2.8
Major Depression (MDD) 2.8 3.4 6.2 1.9 1.3 -2.1 2.5 2.2 0.1
Reaction Time 3.9 7.5 15.8 2.3 4.0 -1.1 2.1 2.8 3.2
Verbal and Numeric Reasoning (VNR) 2.5 6.0 16.1 -1.0 -4.0 1.6 -2.4 -2.5 -2.0
Breast Cancer 0.4 1.1 4.5 -2.1 0.5 -1.2 -0.3 -0.2 -0.5
Ovarian Cancer 1.0 1.3 3.0 -0.2 -1.4 0.4 -1.3 -1.7 -1.0
Prostate Cancer 0.1 0.2 0.3 -0.4 0.1 0.2 -0.5 -0.5 -0.4
Age at First Birth 0.3 0.5 0.8 0.8 0.2 -0.2 0.9 -0.9 -0.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.2 0.6 -0.4 -0.4 0.2 -0.1 -0.8 0.0
Coronary Artery Disease (CAD) 0.6 0.8 2.0 -1.4 0.0 -1.4 -0.4 -0.5 -0.5
Crohns Disease (2012) 0.7 1.1 2.3 0.2 1.5 -0.9 1.1 -0.5 1.4
Mean Putamen Volume 1.0 1.1 1.9 0.4 -0.0 -1.2 -1.3 -1.1 -1.4
Fasting Glucose 0.1 0.1 0.3 0.5 -0.2 -0.2 0.2 0.4 -0.4
HbA1C 0.2 0.2 0.5 0.7 0.4 -0.4 0.7 0.3 0.3
HDL Cholesterol 1.6 2.7 4.7 1.8 2.2 -1.4 1.3 2.1 0.7
LDL Cholesterol 0.8 1.3 3.2 0.8 -1.0 1.8 -0.2 -1.6 -0.6
Lupus 0.9 1.3 2.2 1.1 1.0 -0.5 1.5 1.5 0.9
Neuroticism (2016) 3.5 5.1 7.6 2.8 2.7 -2.5 1.6 1.4 2.2
Primary Biliary Cirrhosis 0.7 1.0 2.6 1.2 1.6 -0.3 0.2 0.9 1.1
Rheumatoid Arthritis 0.2 0.2 0.5 -0.7 0.6 -0.5 0.1 0.0 -0.5
Schizophrenia (2014) 1.9 4.3 10.9 0.6 2.1 -3.3 0.8 3.0 -0.4
Triglycerides 0.1 0.1 0.5 -0.7 -0.1 0.1 -0.1 -0.2 -0.0
Type 2 Diabetes (T2D) (2012) 2.8 3.2 7.6 -2.4 -2.0 0.6 -1.0 -2.8 -0.7
Ulcerative Colitis 0.8 1.2 5.3 -0.3 0.5 -0.4 -0.4 -1.1 2.3
Blood Eosinophil Count 0.0 0.3 0.6 0.7 0.4 -0.8 0.3 0.4 -0.0
Blood Platelet Count 0.3 3.6 8.1 1.8 2.8 -0.3 1.2 2.1 2.0
Blood Red Count 0.0 0.4 0.8 0.1 0.0 -0.5 0.5 -0.9 0.9
Blood White Count 0.5 4.0 9.2 0.9 1.5 1.6 3.0 1.8 2.4
Heel T-Score 0.7 5.2 14.7 2.3 3.0 -3.8 0.5 0.6 1.2
BMI 0.2 1.0 2.0 -1.0 -1.2 1.4 -0.3 -1.3 0.1
Height 0.6 12.0 22.9 -3.9 -3.8 2.2 -2.9 -2.5 -4.8
Waist Hip Ratio (WHR) 0.5 2.4 6.5 1.5 2.5 -0.5 0.5 -1.2 1.9
Systolic Blood Pressure 0.2 1.1 3.5 -0.7 -0.0 0.9 -0.4 -1.9 1.3
Smoking Status 4.6 10.9 20.9 2.7 4.6 -2.8 3.4 3.3 2.6
Allergy or Eczema 0.7 1.8 4.2 1.6 0.6 -1.4 1.4 2.1 -0.1
Cardiovascular Disease 1.0 3.4 6.2 -1.7 -1.8 2.5 -1.9 -1.9 -0.9
Hypothyroidism (self reported) 0.1 0.2 0.4 0.3 0.6 -0.5 0.4 -0.1 -0.6
Respiratory disease 0.6 1.4 2.8 1.0 1.5 -1.2 0.8 1.7 0.1
Type 2 Diabetes (T2D) (2018) 0.4 0.7 3.6 0.2 -0.6 0.5 -0.3 -0.2 -1.9
Lung FEV1/FVC ratio 0.6 3.0 8.0 -1.0 -2.8 1.0 -0.2 -2.0 -2.0
Lung FVC 0.6 3.3 12.2 3.5 0.4 -2.1 1.6 0.5 0.4
Neuroticism 6.9 16.6 29.9 2.2 5.5 -4.1 4.5 4.4 2.8
Chronotype (morning person) 0.2 0.4 1.6 -0.6 0.0 -1.3 -0.2 -0.5 -0.1
Hair Pigment 0.3 8.9 19.2 -1.4 -4.4 2.0 -3.2 -3.9 -1.9
Tanning 0.7 8.3 18.4 2.1 3.9 -4.3 1.2 2.4 2.1
Hand grip strength (left) 0.3 0.8 1.6 0.8 1.1 -1.3 -1.1 0.1 -0.4
Number of treatments/medications taken 0.1 0.2 0.3 0.2 -0.1 0.4 -0.5 -0.6 -0.3
Average weekly spirits intake 0.5 0.6 1.7 -0.3 0.9 -0.0 -1.0 -0.5 1.3
Sensitivity / hurt feelings 5.8 9.9 16.7 3.0 4.0 -4.1 2.7 2.6 2.0
Frequency of depressed mood in last 2 weeks 3.5 4.9 12.2 1.0 2.1 -0.9 3.5 2.9 1.6
Hearing difficulty/problems: Yes 0.9 1.4 2.9 0.0 -1.4 0.4 -1.4 -1.0 -1.7
Relative age of first facial hair 3.0 6.1 12.4 -2.7 -3.5 2.7 -1.7 -1.8 -1.9
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.3 -0.2 -0.6 -0.0 1.1 0.0 -0.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.8 -0.6 0.7 -0.9 0.7 0.3 0.1
Ever had hysterectomy (womb removed) 1.6 1.8 3.2 -1.1 -1.8 -0.7 -0.1 -1.8 -1.8
Systolic blood pressure, automated reading 0.1 0.2 0.6 0.8 -0.2 -0.3 -0.3 -0.5 0.4
Eye problems/disorders: Diabetes related eye disease 1.7 1.8 4.5 1.1 1.3 -0.2 2.1 1.8 0.6
Angina 0.3 0.4 1.5 0.6 0.1 0.6 0.5 1.2 -0.3
Medication for hormone replacement therapy 0.9 1.0 2.0 -0.1 1.4 -1.1 1.4 0.8 0.0
Vitamin and mineral supplements 0.1 0.2 0.8 0.1 0.4 0.2 0.9 0.4 0.1
Supplements: Zinc 0.5 0.6 1.2 1.1 1.1 -0.9 0.3 -0.2 0.4
Medication: Co-codamol 0.5 0.5 2.3 -0.4 -0.8 1.5 -0.1 -0.4 0.0
Medication: Metformin 0.6 0.9 2.4 0.6 0.5 1.5 0.6 -0.4 1.3
Diabetes (father) 1.3 1.6 6.3 -0.2 -0.8 2.5 0.7 -0.5 1.3
Diabetes (mother) 0.5 0.7 1.9 0.2 0.7 0.3 1.4 0.9 0.9
Severe depression (siblings) 2.1 2.3 3.4 1.0 1.8 -1.7 1.0 1.6 1.8
Pack years adult smoking proportion 1.4 2.2 4.4 1.0 2.1 -0.3 1.6 1.2 2.0
Impedance of leg (right) 0.4 1.9 6.5 -1.4 -1.1 2.5 0.0 -1.0 -1.0
Leg fat-free mass (left) 0.4 1.9 3.7 -1.2 -1.9 0.7 -1.1 -0.8 -1.9
Trunk fat percentage 2.4 9.7 16.6 -2.8 -3.9 4.1 -2.2 -2.7 -2.4
Hand grip strength (right) 0.3 0.9 1.9 -0.4 0.2 -1.1 -1.4 -0.6 -1.3
Townsend deprivation index at recruitment 1.5 2.0 3.9 -1.6 -2.0 2.0 0.6 0.3 -1.1
Current tobacco smoking 2.2 3.6 7.9 0.9 2.8 -1.8 1.1 2.2 1.8
Average weekly fortified wine intake 0.7 0.8 1.9 -0.0 -0.8 1.4 -1.2 -0.9 0.2
Maternal smoking around birth 1.0 1.4 3.6 1.0 1.7 -1.9 0.6 0.2 0.7
Fed-up feelings 1.9 3.4 9.4 0.8 1.7 0.0 2.7 3.1 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 2.6 3.5 8.0 1.5 1.1 -2.2 2.8 2.1 -0.2
Relative age voice broke 0.3 0.5 0.7 -0.6 -0.8 0.5 -0.7 -0.9 0.5
Taking other prescription medications 0.8 1.3 3.4 -0.1 -1.8 1.3 -1.0 -0.3 -1.3
Age when periods started (menarche) 0.2 0.4 1.6 0.0 -0.2 0.0 -0.6 0.7 -1.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.8 -0.9 -0.8 0.0 0.2 -0.9 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.3 2.9 4.4 1.9 1.9 -0.7 2.1 1.8 1.6
Tinnitus: Yes, but not now, but have in the past 2.5 2.7 6.4 -1.1 -2.2 0.1 -1.5 -1.0 -2.5
Qualifications: CSEs or equivalent 1.1 1.4 3.7 -1.1 -1.3 0.3 -1.9 -0.9 -0.9
Serious illness, injury or assault to yourself 0.6 0.8 2.5 0.6 -0.4 0.2 1.2 0.4 -1.6
High blood pressure 0.2 0.4 0.9 -0.4 -0.7 0.9 -0.4 -0.1 -0.9
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.4 0.4 0.2 -1.1 1.0 1.6 -0.2
Multivitamins +/- minerals 1.5 2.0 4.0 -1.3 -1.4 0.8 -2.0 -1.7 -0.9
Stomach or abdominal pain in last month 1.7 2.2 4.7 -1.0 -1.6 -0.7 -1.0 -2.2 -1.8
Supplements: Glucosamine 2.0 2.6 6.1 -0.6 -1.5 0.5 -2.4 -2.5 -0.8
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 3.1 -0.7 -1.8 0.9 -1.4 -0.7 -1.2
Medication: Atenolol 0.6 0.8 2.2 -0.2 -0.9 -0.4 -0.6 -1.0 -1.5
Medication: Levothyroxine sodium 0.1 0.2 1.0 0.0 -0.0 0.3 -0.7 -1.0 -0.0
Sitting height 2.3 16.2 28.3 -3.5 -5.3 3.9 -3.3 -1.5 -5.3
Chronic bronchitis/emphysema (father) 1.8 2.1 5.1 0.6 1.4 -2.3 1.8 1.3 0.1
High blood pressure (mother) 1.1 1.5 3.9 -1.5 -1.6 -0.1 -0.4 -0.2 -2.0
Body mass index (BMI) 0.3 1.2 2.7 -0.6 -1.6 1.2 -0.8 -1.4 -0.1
Impedance of leg (left) 0.6 3.1 9.9 -1.7 -1.4 3.1 -0.9 -1.4 -1.0
Leg predicted mass (left) 0.4 1.9 4.0 -1.2 -1.9 0.6 -1.1 -0.8 -2.0
Trunk fat mass 1.8 7.9 13.8 -2.3 -3.7 3.7 -2.0 -2.1 -2.5
Waist circumference 0.5 1.8 4.1 -0.7 -1.6 2.0 -1.3 -1.1 -0.7
Number of incorrect matches in round 4.1 6.8 9.6 2.7 3.1 -1.6 2.6 2.7 2.7
Past tobacco smoking 3.1 5.6 8.4 -2.2 -2.7 2.5 -2.9 -2.6 -0.4
Alcohol usually taken with meals 0.3 0.5 1.2 1.1 -0.3 0.6 -0.9 -0.5 -0.7
Nervous feelings 3.6 6.7 10.6 1.5 3.0 -3.3 2.5 3.0 1.6
Frequency of tenseness / restlessness in last 2 weeks 4.0 6.2 9.7 1.9 2.8 -2.8 3.1 2.3 1.5
Hearing difficulty/problems with background noise 1.4 2.3 4.8 -0.5 -1.6 1.8 -1.8 0.1 -2.2
Hair/balding pattern: Pattern 2 0.7 0.9 2.3 -1.5 -0.2 -0.5 -1.5 -0.6 -0.3
Had menopause 0.2 0.2 0.5 0.5 -0.1 -0.3 0.5 -0.7 0.4
Had other major operations 0.5 0.6 2.1 0.8 -0.8 1.5 -0.1 -0.4 -0.4
Forced vital capacity (FVC) 0.3 1.1 2.0 1.3 -0.7 -0.4 1.1 1.0 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.2 1.5 1.1 -1.2 1.1 1.2 0.7
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.0 -0.8 0.2 -0.0 -0.1 1.0 -1.4
Qualifications: None of the above 4.2 9.0 17.3 2.1 3.3 -2.3 3.8 4.2 1.3
Financial difficulties in last 2 years 0.3 0.4 1.1 0.1 0.3 -1.1 -1.0 -0.0 -0.4
Mouth/teeth dental problems 1.0 1.5 3.0 -1.1 -1.7 0.7 -1.6 -0.9 -1.2
Heart attack 0.5 0.7 3.6 -0.2 0.2 1.9 0.1 -0.5 0.3
Allergy 0.4 0.9 2.3 -0.8 -0.0 1.2 -0.7 -1.5 0.7
Pain all over the body in last month 3.6 3.9 9.1 2.1 1.3 0.5 3.0 1.6 2.3
Diabetes (self-reported) 0.5 0.7 2.3 1.0 0.2 1.5 0.9 0.2 0.5
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.6 -1.2 -1.0 -0.9 -0.4 -0.7 -1.3
Medication: Ramipril 0.5 0.7 1.2 -1.1 -0.7 1.1 -0.9 -0.4 -0.4
Medication: Simvastatin 1.0 1.4 7.4 0.4 -0.7 2.7 0.5 -0.6 -0.1
Fluid intelligence score 0.8 1.7 3.6 0.6 -1.9 0.9 -1.6 -1.3 -0.9
Illnesses of siblings 1.0 1.4 3.1 -0.9 -0.5 -1.1 -1.7 -1.7 0.2
Neuroticism score 5.9 12.4 20.1 2.3 4.5 -3.5 3.9 4.1 2.0
Weight 0.8 4.2 9.0 -1.4 -3.0 2.3 -1.6 -1.6 -1.9
Impedance of arm (right) 1.5 7.0 10.4 -3.2 -3.0 2.7 -2.3 -2.5 -2.0
Arm fat percentage (right) 0.9 3.4 6.5 -1.5 -2.5 2.4 -1.3 -1.9 -0.6
Trunk fat-free mass 0.1 0.3 1.0 0.3 -0.6 0.1 -0.1 0.6 -1.0
Hip circumference 1.6 6.9 14.7 -2.4 -3.8 3.3 -2.1 -1.4 -2.0
Time employed in main current job 0.1 0.1 0.3 0.1 0.5 -0.4 0.2 0.4 0.1
Alcohol intake versus 10 years previously 1.6 2.4 5.7 1.9 0.7 -1.0 1.6 2.4 -1.0
Father’s age at death 0.9 1.2 2.7 -1.6 -0.9 0.3 -0.8 -0.4 -1.6
Worrier / anxious feelings 2.0 3.8 6.6 1.2 2.6 -2.4 1.5 1.8 2.0
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.2 6.2 2.5 1.5 -1.8 2.2 1.7 0.3
Falls in the last year 0.6 0.8 1.4 -1.2 -1.1 0.0 -1.1 -1.1 -0.4
Hair/balding pattern: Pattern 3 2.3 3.5 8.0 1.9 2.8 -2.2 1.1 1.1 1.5
Number of live births 0.2 0.3 1.1 -0.4 -0.2 0.5 -0.4 -0.4 1.1
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 4.4 0.3 -2.1 0.4 0.4 -0.1 -2.1
Pulse rate 0.2 0.3 1.1 0.3 -0.6 -0.0 -1.0 -0.1 -0.4
Happiness 0.3 0.4 0.6 0.8 -0.4 -0.7 -0.5 -0.6 0.8
Noisy workplace 1.8 2.2 7.6 0.6 1.9 -2.8 0.6 0.2 1.0
Qualifications: A levels/AS levels or equivalent 1.7 3.8 8.8 -1.5 -3.0 1.9 -1.6 -1.5 -1.8
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.6 0.9 0.4 0.0 1.6 1.1 -1.1
Mouth/teeth dental problems: Dentures 0.4 0.6 1.4 1.0 1.2 0.3 0.7 0.2 0.8
Asthma 0.2 0.3 0.7 0.5 0.6 -0.7 -0.3 0.8 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 4.7 -1.1 1.3 -2.2 -0.9 0.4 0.7
Medication: Cholesterol lowering 0.6 0.9 2.6 0.8 0.4 1.4 1.6 0.5 0.4
Depression (self-reported) 0.7 0.8 2.4 -0.5 -0.1 -0.8 0.2 1.6 -1.1
Medication: Lansoprazole 0.8 0.9 1.9 -0.1 -1.2 -1.3 -0.5 -0.1 -1.4
Prospective memory result 3.4 4.2 8.6 1.5 2.9 -2.3 1.7 1.7 1.9
Lung cancer (father) 0.3 0.3 0.8 0.8 0.0 -0.3 0.4 -0.1 0.9
Illnesses of mother 0.6 0.7 1.8 1.0 0.9 0.6 -0.3 -0.5 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 3.1 -0.1 -1.8 0.0 0.7 -0.4 -1.5
Pulse wave Arterial Stiffness index 0.2 0.3 0.6 -0.1 -0.7 0.8 0.5 0.6 -0.4
Impedance of arm (left) 2.1 9.7 13.2 -3.6 -3.4 3.4 -2.8 -3.0 -2.4
Arm fat mass (right) 0.8 3.3 6.4 -1.3 -2.5 2.2 -1.4 -1.8 -1.1
Trunk predicted mass 0.0 0.3 0.8 0.3 -0.6 0.1 -0.2 0.6 -0.9
Standing height 0.7 6.8 16.6 -1.8 -3.1 2.6 -1.8 -0.7 -4.1
Length of working week for main job 0.6 0.6 1.4 0.8 0.7 -0.2 1.2 1.2 0.2
Exposure to tobacco smoke at home 0.3 0.4 1.3 -0.7 -0.5 1.1 -0.3 -0.4 -0.1
Breastfed as a baby 0.9 1.1 2.6 0.4 -1.2 0.1 -1.6 -1.4 -0.8
Tense / ‘highly strung’ 3.5 5.7 16.9 1.5 2.1 -4.1 2.3 2.3 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 7.9 -0.7 -0.2 -1.9 0.3 1.3 -2.8
Hair/balding pattern: Pattern 4 1.0 2.5 6.6 1.9 1.2 0.9 1.4 2.6 -0.6
Birth weight of first child 0.6 1.1 1.7 -1.0 -1.1 0.7 -0.8 -1.3 -1.2
Peak expiratory flow (PEF) 3.8 8.8 13.5 -2.2 -3.7 3.3 -2.9 -2.7 -2.8
Pulse wave reflection index 0.1 0.1 0.3 -0.3 -0.6 -0.0 0.3 -0.1 -0.0
Ever highly irritable/argumentative for 2 days 1.7 2.0 3.3 1.2 1.7 -1.8 1.2 1.3 0.9
Loud music exposure frequency 0.9 1.0 2.8 1.7 0.7 -0.9 1.1 0.5 0.6
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 4.8 -1.2 -1.7 2.2 -1.3 -1.1 -0.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.7 0.1 0.7 -0.8 0.5 -0.1 0.6
Blood clot in the leg (DVT) 1.5 1.9 3.6 1.3 1.3 -0.9 1.9 1.2 1.4
Medication: Paracetamol 1.0 1.7 7.6 -2.8 -1.0 0.3 0.5 0.3 -1.1
Headache pain in last month 1.7 2.9 5.9 -2.4 -2.2 0.2 -1.1 -1.3 -2.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.1 -1.5 -0.7 -0.7 -0.5 -0.2 -0.8
Glaucoma (self-reported) 1.9 2.2 5.2 -0.9 -2.3 1.5 -0.5 -1.5 -1.6
Gout (self-reported) 0.5 0.7 1.2 -1.0 -1.0 0.2 -1.1 -0.9 -0.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.7 -0.2 0.7 -0.6 -0.0 -0.9 -0.1
Medication: Amlodipine 0.9 1.3 5.3 -0.7 -0.7 -0.7 -0.9 -0.1 -2.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 -0.4 1.0 -0.6 -0.3 1.0 -0.2
Birth weight 2.9 6.3 11.7 -3.4 -2.8 0.3 -2.3 -2.8 -2.3
Chronic bronchitis/emphysema (mother) 0.8 1.0 2.9 -1.0 -0.4 -0.8 -1.1 -1.7 -0.1
High blood pressure (siblings) 0.8 1.1 2.6 0.4 -0.3 1.2 1.3 1.6 -0.9
Forced vital capacity (FVC), Best measure 0.1 0.5 1.0 0.5 -0.8 -0.4 0.8 0.4 -1.0
Body fat percentage 1.7 6.7 13.7 -2.0 -3.3 3.7 -1.9 -2.4 -1.5
Leg fat percentage (right) 0.5 1.8 6.2 -0.5 -1.7 2.5 -0.4 -1.1 -0.0
Arm fat-free mass (right) 0.1 0.5 1.4 0.4 -0.7 0.6 -0.1 0.6 -1.2
Exposure to tobacco smoke outside home 1.2 1.5 3.8 -0.4 1.9 -0.3 1.2 1.3 1.4
Comparative body size at age 10 1.8 5.1 11.6 1.6 2.3 -3.4 2.1 2.0 1.6
Number of full brothers 0.4 0.5 1.1 0.7 -0.8 1.1 -0.6 -0.3 -0.0
Worry too long after embarrassment 1.2 2.0 5.2 1.4 1.5 -2.3 1.0 0.6 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 6.7 -0.3 0.2 -2.3 0.9 1.8 -2.6
Wheeze or whistling in the chest in last year 1.2 2.2 4.6 0.9 2.1 -1.5 1.3 1.8 0.4
Number of children fathered 1.6 1.8 6.4 2.5 0.4 0.0 1.2 -0.4 1.6
Reason for reducing amount of alcohol drunk: Health precaution 2.1 2.5 3.9 1.5 1.9 -1.0 2.0 2.0 0.6
Age at first live birth 0.4 0.7 3.0 0.3 0.1 -0.5 -1.7 -0.3 0.9
Pulse wave peak to peak time 0.2 0.2 0.5 -0.2 0.3 -0.3 -0.7 -0.7 -0.0
Health satisfaction 0.3 0.4 1.0 1.0 0.0 0.3 -0.9 0.4 0.3
Shortness of breath walking on level ground 2.6 3.1 6.0 2.4 2.1 -0.7 1.3 2.3 0.7
Qualifications: College or University degree 3.2 9.9 20.7 -3.2 -4.6 3.6 -2.2 -2.2 -2.5
Eye problems/disorders: None of the above 0.9 1.0 3.6 -0.1 0.6 -1.0 -1.9 -0.9 0.5
Mouth/teeth dental problems: Loose teeth 0.8 1.0 2.2 -0.7 1.3 -1.5 -0.6 1.0 0.3
Emphysema/chronic bronchitis 0.7 0.8 2.7 -0.3 -0.3 -0.8 1.0 0.7 -1.6
Medication for pain relief, constipation, heartburn 0.3 0.4 1.0 1.0 -0.0 1.0 0.3 -0.2 0.6
Neck or shoulder pain in last month 0.6 0.8 2.1 0.5 1.5 -0.6 0.4 1.1 0.9
Medication: Blood pressure 0.1 0.2 0.9 0.9 0.0 0.5 -0.3 -0.4 -0.2
Angina (self-reported) 0.4 0.5 1.5 0.9 0.1 0.7 0.6 1.2 -0.4
Migraine (self-reported) 3.8 4.8 9.4 -2.1 -2.2 -0.9 -2.6 -1.5 -3.1
Medication: Ibuprofen 0.7 0.8 2.4 -1.5 0.5 -0.9 -1.1 0.0 0.2
Medication: Allopurinol 0.3 0.4 1.1 -1.0 -0.7 0.8 -0.0 0.3 -0.4
Medication: Omeprazole 2.7 3.2 6.0 2.4 1.6 0.3 2.5 2.2 0.2
Medication: Seretide 50 evohaler 0.8 0.9 2.5 -1.6 0.8 0.5 1.1 1.0 -0.2
Mean time to correctly identify matches 6.5 12.4 23.2 3.2 4.8 -1.3 3.1 4.1 3.6
Heart disease (mother) 1.4 1.8 4.8 -2.2 -0.7 -1.1 1.0 0.3 -1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.6 -0.5 0.8 -0.4 0.6 0.7 0.2
Whole body fat mass 1.2 4.9 9.6 -1.6 -2.9 3.1 -1.6 -1.9 -1.6
Leg fat mass (right) 0.7 2.8 5.6 -1.0 -2.3 2.4 -1.0 -1.6 -1.0
Arm predicted mass (right) 0.1 0.5 2.1 0.2 -0.8 0.5 -0.3 0.3 -1.4
Pulse rate, automated reading 0.1 0.3 0.5 -0.6 0.2 -0.1 -0.6 0.7 0.6
Alcohol intake frequency. 0.3 0.7 1.6 -0.0 -0.3 -1.2 0.9 0.4 -1.2
Comparative height size at age 10 0.5 3.0 9.9 -1.4 -1.5 3.1 0.8 0.3 -1.8
Number of full sisters 1.4 1.7 3.8 -2.0 -1.0 1.2 -0.2 1.0 -1.7
Suffer from ‘nerves’ 3.7 5.8 12.6 1.1 2.5 -3.0 2.4 3.5 -0.2
Overall health rating 0.2 0.5 1.3 0.0 -0.4 0.8 1.1 -0.2 0.8
Chest pain or discomfort 0.5 0.7 1.5 -0.4 0.2 0.0 1.2 1.2 -1.0
Had major operations 0.5 0.6 2.5 0.5 0.1 1.6 -0.1 0.8 -0.2
Age at last live birth 0.4 0.6 2.1 0.2 0.0 0.6 -1.1 0.0 1.4
Family relationship satisfaction 0.5 0.6 1.9 -0.2 -1.4 1.2 -0.1 -0.1 -0.4
Leg pain on walking 1.1 1.4 2.8 0.3 0.9 -1.6 1.4 1.7 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.1 -0.8 0.3 -1.0 -1.5 -0.7 -0.8
Commuting to job workplace: Car/motor vehicle 1.0 1.2 4.5 0.2 1.2 -2.1 -0.3 -0.8 0.5
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.9 -0.4 0.3 0.6 0.9 0.5 1.4
Medication: Aspirin 0.2 0.3 0.6 -0.0 -0.7 0.8 -0.1 -0.7 -0.5
Supplements: Vitamin C 0.8 0.9 2.7 0.2 0.1 -1.7 -1.1 0.7 -1.0
Knee pain experienced in last month 0.6 0.9 1.9 1.3 1.1 -1.4 0.0 0.4 -0.3
Hypertension (Self-reported) 0.3 0.7 1.9 -0.5 -1.0 1.0 -0.5 -0.3 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.1 0.7 -0.4 0.6 0.9 1.0 -1.4
Illnesses of father: Heart disease 0.8 1.2 2.3 0.6 1.3 0.3 1.4 1.5 0.6
Illnesses of siblings: Diabetes 0.9 1.2 2.4 -0.5 -1.1 1.6 -0.6 -0.6 -1.6
Smoking status: Previous 1.7 2.5 5.2 1.2 1.6 -2.0 2.3 1.4 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 1.0 -0.1 0.3 -0.3 1.0 -0.2 0.1
Whole body fat-free mass 0.1 0.5 1.7 -0.2 -1.0 0.4 -0.4 0.3 -1.3
Leg fat-free mass (right) 0.3 1.7 3.1 -1.1 -1.8 0.8 -1.3 -0.8 -1.6
Arm fat percentage (left) 1.2 4.9 8.6 -1.8 -2.9 2.8 -1.8 -2.4 -0.9
Average weekly red wine intake 1.0 1.4 7.1 -0.1 -0.6 2.7 -0.9 -0.5 -0.4
Handedness (chirality/laterality): Left-handed 0.5 0.7 2.6 -0.8 0.1 0.8 0.3 -0.2 1.6
Mood swings 9.9 17.9 30.6 3.9 5.5 -4.2 4.5 4.5 1.5
Loneliness, isolation 0.4 0.6 1.1 0.8 0.4 0.9 1.1 0.8 -0.2
Long-standing illness, disability or infirmity 0.3 0.5 1.3 0.7 -0.1 -0.0 1.2 1.0 -0.3
Ever had bowel cancer screening 0.6 0.7 2.5 0.6 -0.5 -0.3 -1.6 0.3 -0.9
Diabetes diagnosed by doctor 0.3 0.6 2.2 0.9 0.1 1.5 0.5 0.4 0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 3.7 1.7 0.2 -0.3 0.5 1.9 -1.0
Friendships satisfaction 0.3 0.4 1.7 1.3 -0.3 0.1 -0.3 0.2 0.5
Qualifications: nursing, teaching 1.4 2.2 6.1 -0.6 -1.7 1.5 -1.2 -2.5 0.1
Commuting to job workplace: Walk 0.6 0.6 1.3 -1.1 -0.7 0.4 -1.1 -0.7 -0.4
Eye problems/disorders: Cataract 0.4 0.4 1.4 0.4 0.6 -0.5 0.5 1.2 0.3
Mouth/teeth dental problems: Mouth ulcers 2.0 3.2 9.9 0.9 1.0 1.2 3.2 1.8 1.7
Medication for cholesterol 0.6 0.9 2.3 0.8 1.0 -1.1 0.2 0.3 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.5 -0.8 0.1 -1.0 -0.8 -0.1 -1.6
Back pain experienced in last month 0.2 0.3 1.0 -0.0 0.2 -1.0 0.7 0.3 0.6
Mineral and other dietary supplements 2.0 2.7 6.4 -0.0 1.9 -1.1 2.1 2.5 0.8
Breast cancer (self-reported) 1.8 2.2 3.8 1.3 0.4 1.2 2.0 1.7 1.7
Asthma (self-reported) 0.2 0.4 1.0 0.7 0.7 -0.7 -0.1 1.0 -0.4
Osteoporosis (self-reported) 2.1 2.6 5.6 0.4 -1.8 1.5 -2.1 -2.4 0.2
Osteoarthritis (self-reported) 2.3 3.0 5.9 1.3 2.0 -1.3 1.8 2.4 1.1
Medication: Aspirin 0.1 0.1 0.4 0.6 -0.1 0.3 0.1 -0.6 -0.0
Medication: Gliclazide 0.9 1.0 2.3 -0.5 -1.3 0.5 -1.2 -1.5 -0.3
Illnesses of father: None of the above (group 1) 1.8 2.3 5.0 -2.2 -1.6 -0.2 -2.1 -0.8 -1.0
Smoking status: Current 2.7 4.3 8.5 1.5 2.9 -1.5 1.7 2.5 1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.9 1.0 -0.6 -0.2 2.0 1.2 -0.0
Whole body water mass 0.1 0.6 1.8 -0.2 -1.1 0.4 -0.4 0.3 -1.4
Leg predicted mass (right) 0.4 2.0 3.6 -1.2 -1.9 0.9 -1.5 -1.0 -1.7
Arm fat mass (left) 0.9 3.9 8.0 -1.5 -2.8 2.3 -1.5 -1.9 -1.3
Number of self-reported non-cancer illnesses 1.3 2.3 5.2 -1.0 -1.9 1.6 -1.1 -0.3 -2.3
Average weekly champagne plus white wine intake 0.9 1.2 2.8 -0.8 -0.2 -1.7 -1.4 -0.5 -1.1
Miserableness 1.0 1.8 5.4 0.6 1.0 0.3 1.8 2.3 -0.6
Guilty feelings 1.6 2.4 4.7 0.2 2.2 -1.6 1.4 1.7 1.4
Wears glasses or contact lenses 0.6 0.6 3.6 0.4 -0.0 1.9 -0.0 -0.2 0.2
Ever taken oral contraceptive pill 0.3 0.3 0.7 -0.5 0.4 -0.2 -0.5 -0.8 0.7
Hearing aid user 4.5 5.1 12.4 3.5 1.9 0.0 2.5 2.0 2.1
Mother’s age at death 1.1 1.4 4.2 -0.1 -1.2 -0.2 -2.1 -1.2 -1.0
Financial situation satisfaction 1.0 1.3 5.8 0.6 1.1 -2.4 -0.1 0.4 0.3
Tinnitus: Yes, now most or all of the time 0.8 1.0 3.0 1.7 -0.2 1.0 0.9 -0.1 1.0
Commuting to job workplace: Public transport 0.8 1.0 4.1 -0.7 -0.7 2.0 -0.8 0.2 -0.1
Eye problems/disorders: Glaucoma 1.6 1.9 4.4 -0.8 -2.1 2.0 -0.2 -1.0 -1.2
Medication: Blood pressure 0.6 1.1 2.2 -0.9 -1.5 1.2 -0.3 -0.1 -1.5
Pain type(s) experienced in last month: Hip pain 0.8 1.1 2.2 1.1 1.5 -0.8 1.1 0.9 0.7
Supplements: Fish oil (including cod liver oil) 1.3 1.7 5.0 0.1 -1.3 1.2 -2.2 -1.4 -0.4
High cholesterol (Self-reported) 0.8 1.4 7.0 -0.3 -0.4 2.7 -0.1 0.7 -0.7
Medication: Bendroflumethiazide 1.7 2.5 4.6 -2.1 -1.8 1.4 -1.6 -1.5 -0.8
Medication: Paracetamol 1.1 1.7 8.3 -2.9 -0.6 -0.1 0.5 0.0 -1.1
Medication: Lisinopril 0.5 0.7 2.2 -0.6 -0.9 1.5 -0.1 -0.6 -0.4
Medication: Atorvastatin 1.5 1.9 4.3 0.8 1.4 0.2 1.9 2.1 -0.8
Illnesses of father: High blood pressure 0.2 0.3 1.1 0.1 1.1 0.2 0.3 0.6 -0.3
Alcohol drinker status: Never 1.3 1.5 2.6 -1.0 -1.6 -0.8 -1.1 -1.2 -1.5
Ever smoked 1.4 2.5 3.9 0.9 1.9 -2.0 1.6 2.0 -0.1
Basal metabolic rate 0.2 1.2 2.7 -0.6 -1.6 1.0 -0.7 -0.3 -1.6
Leg fat percentage (left) 0.7 2.7 8.8 -0.7 -1.9 3.0 -1.1 -1.3 0.2
Arm fat-free mass (left) 0.0 0.2 0.7 0.2 -0.6 0.3 -0.1 0.6 -0.8
Number of operations (self-reported) 0.2 0.3 0.8 0.5 -0.4 0.9 0.8 -0.2 -0.2
Average weekly beer plus cider intake 0.4 0.5 1.3 -0.1 0.7 -0.0 0.7 1.2 0.9
Irritability 5.6 9.6 16.5 4.1 3.4 -2.7 3.2 2.8 1.9
Risk taking 0.8 1.1 4.3 0.3 -1.1 0.0 0.9 0.4 -2.1
Ever had prostate specific antigen (PSA) test 2.3 2.7 7.4 1.1 2.0 0.2 1.7 2.7 0.6
Fractured/broken bones in last 5 years 1.5 2.0 4.3 -1.0 -1.4 2.0 -0.5 -2.1 -0.4
Age started oral contraceptive pill 0.9 1.1 5.2 -0.2 -0.7 2.3 -0.5 -0.2 0.7
Diastolic blood pressure, automated reading 2.3 7.1 13.9 -2.5 -3.7 1.2 -2.6 -2.3 -3.0
Ever depressed for a whole week 0.2 0.3 1.0 1.0 0.2 0.7 0.2 0.2 -0.2
Unable to work because of sickness or disability 1.9 2.4 5.8 1.7 0.9 0.1 2.4 1.9 1.1
Commuting to job workplace: Cycle 2.8 3.3 6.6 -2.3 -2.0 2.6 -1.2 -0.6 -1.5
Myopia 0.4 0.6 2.0 -0.6 0.1 -1.4 -0.8 0.4 -0.8
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.1 0.7 0.6 -1.0 0.6 0.3 0.9
Cholesterol lowering medication 0.9 1.3 4.7 0.9 0.3 2.2 0.3 1.4 -0.3
Medication: Omeprazole (e.g. Zanprol) 3.1 3.8 8.8 3.0 1.6 -0.2 2.5 2.2 0.3
Pain experienced in last month 1.2 2.0 3.2 -1.1 -1.5 1.8 -1.7 -1.4 -0.4
Supplements: Calcium 2.1 2.3 4.8 -0.2 -1.8 1.8 -1.4 -2.2 -0.7
Basal cell carcinoma (self-reported) 1.2 1.4 2.2 -1.4 -1.2 0.9 -1.5 -1.3 -0.7
Heart attack/myocardial infarction (self-reported) 0.7 0.9 4.7 -0.2 0.1 2.2 0.2 -0.6 0.3
Deep venous thrombosis (DVT) (self-reported) 2.0 2.6 4.8 1.3 1.7 -0.9 2.2 1.6 1.8
Heart disease (siblings) 0.5 0.6 1.2 -1.1 -1.0 0.7 0.1 0.5 -1.0
Alcohol drinker status: Previous 0.6 0.7 1.8 -1.0 -0.4 -0.6 1.3 0.5 -0.7
Pack years of smoking 2.0 2.9 6.1 1.2 2.5 -0.5 1.9 1.6 2.0
Impedance of whole body 1.2 6.4 11.0 -3.0 -2.4 3.3 -2.0 -2.2 -1.9
Leg fat mass (left) 0.9 3.7 7.3 -1.2 -2.5 2.7 -1.5 -1.8 -1.0
Arm predicted mass (left) 0.1 0.3 1.1 0.3 -0.8 0.3 -0.2 0.3 -1.0