Hub : Genes

FBXO42

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0520	0.0220	1.6e-03	0.030	0.020	0.019	0.022	0.020	1.4e-04	1.6e-03	2.0e-03	9.6e-04	1.5e-03
2	GTEx	Breast Mammary Tissue	0.1010	0.0420	1.0e-03	0.074	NA	0.020	NA	0.030	1.2e-04	NA	3.1e-02	NA	1.1e-02
3	GTEx	Breast Mammary Tissue (Male)	0.1090	0.0712	7.1e-02	0.038	NA	0.036	NA	0.030	4.7e-02	NA	5.1e-02	NA	6.8e-02
4	GTEx	Breast Mammary Tissue (Female)	0.0424	0.0448	2.0e-01	-0.010	NA	-0.010	NA	0.019	8.7e-01	NA	9.3e-01	NA	8.7e-02
5	GTEx	Skin Sun Exposed Lower leg	0.0620	0.0320	8.1e-03	-0.002	NA	-0.002	NA	-0.001	4.7e-01	NA	4.9e-01	NA	4.1e-01
6	GTEx	Testis	0.3050	0.0650	5.9e-10	0.109	NA	0.247	NA	0.253	1.6e-05	NA	2.5e-11	NA	1.4e-11
7	METSIM	Adipose	0.0363	0.0148	7.2e-04	0.033	0.011	0.018	0.012	0.025	7.9e-06	6.8e-03	8.8e-04	5.7e-03	8.9e-05
8	ROSMAP	Brain Pre-frontal Cortex	0.0944	0.0269	9.1e-10	0.055	0.077	0.089	0.078	0.089	1.2e-07	3.5e-10	1.6e-11	2.8e-10	1.8e-11
9	TCGA	Brain Lower Grade Glioma	0.0213	0.0152	7.9e-03	0.004	0.017	0.015	NA	0.009	9.8e-02	4.2e-03	7.5e-03	NA	2.7e-02
10	TCGA	Testicular Germ Cell Tumors	0.1730	0.1210	5.6e-03	0.064	0.063	0.036	NA	0.064	2.8e-03	2.9e-03	2.0e-02	NA	2.7e-03
11	TCGA	Thyroid Carcinoma	0.0500	0.0240	5.3e-05	0.058	0.052	0.052	NA	0.057	2.7e-06	7.5e-06	7.6e-06	NA	3.2e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.6	-0.5	0.4	0.0	-0.4	-0.5	-0.4	-0.1	-0.3	0.1	-0.2
Bipolar Disorder or Schizophrenia	1.1	2.7	5.2	-1.0	-2.3	-1.5	0.0	-0.2	-2.0	-1.7	-1.8	-2.2	1.9	-1.6
Depressed Affect (Nagel 2018)	0.5	1.2	2.4	-0.9	-0.5	-1.1	-0.8	-0.8	-1.1	-1.2	-1.1	-1.4	0.8	-1.5
Depression (Nagel 2018)	1.0	1.6	4.6	-1.6	-0.8	-0.5	0.1	-2.1	-1.1	-1.6	-1.0	-1.1	0.4	-1.7
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.1	1.2	1.6	0.1	-0.2	1.3	0.5	1.8	0.7	0.6	-0.6	1.1
Neuroticism (Nagel 2018)	0.0	0.1	0.3	0.2	0.6	0.2	-0.1	-0.1	-0.0	0.4	0.2	0.1	-0.6	-0.1
Schizophrenia (2018)	1.8	3.7	6.4	-0.8	-2.5	-2.2	0.0	0.0	-2.2	-1.9	-2.2	-2.5	2.4	-2.0
Schizophrenia vs Biploar Disorder	1.1	1.5	3.1	-0.8	-0.9	-1.7	0.0	-1.0	-0.8	-1.8	-1.3	-1.2	1.2	-1.6
Worry (Nagel 2018)	0.7	1.4	3.9	1.2	0.4	0.7	1.7	2.0	0.8	1.4	1.0	1.0	-0.9	1.1
Alzheimer’s Disease (in mother)	0.8	0.9	2.3	0.8	0.5	0.0	0.2	1.3	1.1	1.5	1.3	1.0	-0.8	1.1
Alzheimer’s Disease (in father)	0.8	0.9	3.4	-1.4	0.0	0.8	-1.8	0.7	-0.2	-1.5	-0.7	-0.0	0.2	-1.0
Alzheimer’s Disease (including proxy)	0.8	1.2	2.3	0.3	0.8	0.8	-1.2	1.3	1.5	1.0	1.1	1.3	-0.9	1.0
Crohns Disease (2017)	0.5	1.2	2.9	0.8	0.3	0.2	-1.1	-1.3	1.7	0.2	1.4	1.4	-1.2	0.9
Irritable Bowel Disease (IBD)	0.8	1.9	3.8	1.8	0.7	-0.4	-0.6	-1.9	2.0	0.6	1.7	1.6	-1.3	1.4
Ulcerative Colitis (UC)	0.4	0.7	2.4	1.4	0.3	-0.9	0.4	-1.5	1.0	0.2	0.8	0.6	-0.4	0.8
Major Depression (MDD)	0.1	0.1	0.5	-0.3	0.7	0.0	0.0	0.2	0.1	0.1	0.3	-0.1	-0.2	-0.6
Reaction Time	0.6	1.2	3.9	-1.3	-0.7	-0.8	-0.0	-0.6	-0.8	-2.0	-1.2	-1.0	1.1	-1.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.0	0.8	0.9	-0.2	0.6	0.9	0.3	1.0	0.1	0.1	0.2	0.3
Breast Cancer	1.8	4.4	8.4	-1.5	-2.9	-2.3	1.4	-0.9	-2.3	-1.9	-1.9	-2.8	2.5	-1.7
Ovarian Cancer	0.3	0.4	1.4	-1.0	-1.2	1.2	-0.2	-0.5	0.2	-0.5	0.1	0.0	0.0	-0.1
Prostate Cancer	0.8	1.2	3.8	-1.1	1.3	1.8	2.0	-0.6	0.4	0.4	0.4	1.0	-1.1	0.0
Age at First Birth	1.1	1.6	3.5	1.2	1.2	0.1	0.0	-0.7	1.4	0.9	1.4	1.7	-1.9	1.6
Bipolar Disorder (2011)	0.4	0.4	1.7	0.0	-0.1	-0.6	0.0	-0.6	-1.3	0.0	0.0	-1.0	0.2	-1.1
Body Mass Index (BMI) (2010)	1.8	2.4	4.9	0.6	2.2	1.9	0.0	-1.5	1.7	0.9	1.8	1.8	-2.2	0.7
Coronary Artery Disease (CAD)	0.6	0.7	5.1	-0.1	-0.7	0.6	0.0	2.2	0.5	0.6	-0.4	-0.0	1.1	-0.1
Crohns Disease (2012)	0.5	0.7	2.1	0.5	0.9	-0.2	0.0	-1.1	1.4	0.1	1.1	1.1	-1.1	0.4
Mean Putamen Volume	0.8	0.9	5.8	-0.8	-0.8	0.5	-0.3	-2.4	-0.4	-1.0	-0.4	-0.6	0.3	-0.8
Fasting Glucose	0.2	0.3	1.7	0.3	0.6	1.3	0.0	0.8	0.2	0.4	0.1	0.2	-0.3	-0.1
HbA1C	0.6	0.7	3.8	0.7	1.9	0.5	0.0	1.0	1.0	-0.1	0.6	0.6	-0.7	0.1
HDL Cholesterol	0.3	0.5	1.3	0.8	-1.1	-1.1	0.0	0.8	-0.8	0.2	-0.3	-0.7	0.7	-0.0
LDL Cholesterol	0.5	0.8	3.1	-0.0	-1.5	-0.0	0.0	1.3	-0.5	-0.1	-0.8	-0.9	1.8	-0.1
Lupus	0.4	0.6	1.4	1.0	0.9	-0.4	0.3	-0.5	0.8	0.5	1.0	1.0	-1.2	0.6
Neuroticism (2016)	0.5	0.7	2.8	1.3	0.2	-1.7	-0.1	1.0	0.7	1.2	0.6	0.5	-0.2	0.5
Primary Biliary Cirrhosis	1.1	1.5	3.6	1.9	1.1	1.1	0.0	-0.2	1.7	0.8	1.4	1.5	-1.1	1.3
Rheumatoid Arthritis	0.5	0.7	2.2	0.5	-1.5	-0.6	0.0	1.3	-0.7	-0.2	-0.5	-0.9	1.0	-0.1
Schizophrenia (2014)	2.7	5.9	9.4	-1.5	-2.9	-2.6	0.0	0.1	-2.3	-3.0	-2.7	-2.8	3.1	-2.9
Triglycerides	0.5	0.9	2.5	-0.4	-1.2	-0.7	0.0	1.6	-0.8	0.4	-1.1	-1.0	1.4	-0.0
Type 2 Diabetes (T2D) (2012)	1.5	1.7	4.1	1.3	1.8	2.0	0.0	1.0	1.3	1.2	1.4	1.4	-1.2	0.7
Ulcerative Colitis	0.3	0.4	1.5	1.0	0.5	-0.7	0.0	-1.2	0.6	0.1	0.4	0.4	-0.4	0.3
Blood Eosinophil Count	0.5	3.8	13.8	0.7	3.3	1.5	-0.9	-3.7	0.5	1.1	1.1	1.6	-2.9	-0.0
Blood Platelet Count	0.3	3.0	8.3	0.0	2.7	1.7	-1.3	-2.9	1.8	-0.0	1.5	1.7	-1.9	-0.2
Blood Red Count	0.8	7.7	21.0	3.6	3.5	1.8	-1.9	4.6	2.5	3.4	2.3	1.8	-1.2	2.1
Blood White Count	0.1	0.7	3.0	-0.6	0.5	1.2	-1.7	0.3	0.4	-0.3	0.0	-0.3	0.6	-1.2
Heel T-Score	0.6	4.7	13.7	1.2	2.5	0.1	0.3	-2.4	2.2	1.2	3.2	2.5	-3.7	0.8
BMI	1.3	7.4	17.4	2.7	1.0	2.2	-0.2	-1.2	3.0	2.7	4.2	2.9	-3.1	3.8
Height	0.4	7.7	29.5	-2.2	0.5	-3.0	0.7	-5.4	-3.4	-2.4	-3.0	-2.3	0.8	-2.9
Waist Hip Ratio (WHR)	0.9	3.9	7.7	2.4	1.5	1.1	1.6	2.1	1.5	2.8	2.0	1.9	-1.9	2.3
Systolic Blood Pressure	0.6	3.0	12.7	1.0	-0.6	-2.3	0.4	3.6	-0.9	1.8	-1.4	-1.2	2.4	0.7
Smoking Status	1.2	2.9	4.9	-1.8	-2.2	-0.7	0.6	-0.4	-2.1	-2.2	-1.7	-2.0	1.4	-2.0
Allergy or Eczema	0.4	1.1	8.4	0.3	1.0	-0.6	2.9	1.1	-0.7	0.9	-0.1	-0.2	-0.5	0.2
Cardiovascular Disease	1.0	3.4	9.9	2.9	1.5	0.4	0.1	2.8	1.0	3.1	1.3	0.9	-0.5	2.3
Hypothyroidism (self reported)	2.8	6.4	10.4	-2.8	-3.2	-1.8	0.3	-1.6	-3.2	-2.5	-3.1	-2.9	2.2	-2.5
Respiratory disease	3.2	7.0	9.6	2.4	2.8	2.8	-1.6	1.3	2.9	2.8	3.1	3.0	-3.0	2.8
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.1	0.7	1.5	0.3	1.8	0.3	0.9	1.6	0.7	1.1	-1.2	1.0
Lung FEV1/FVC ratio	0.8	4.2	20.5	-1.7	1.6	-0.0	1.3	-4.5	1.3	-3.1	1.1	0.6	-1.4	-1.9
Lung FVC	1.4	7.0	16.7	-0.9	-4.0	-2.1	-0.7	4.0	-2.3	0.3	-2.2	-3.3	4.1	-1.2
Neuroticism	0.3	0.6	2.1	1.4	1.1	-0.0	0.2	0.5	0.5	0.8	0.8	0.7	-1.0	0.6
Chronotype (morning person)	0.3	0.8	6.1	0.5	0.6	-1.1	2.5	0.5	0.4	0.2	0.4	0.3	-0.2	-0.2
Hair Pigment	0.1	1.6	7.8	-2.8	-0.4	2.2	-1.5	-0.8	0.2	0.8	0.1	0.4	-1.1	0.4
Tanning	0.2	2.1	11.6	-0.9	-0.0	-1.3	1.3	-3.4	-0.5	-2.1	-0.4	-0.4	-0.5	-1.5
Hand grip strength (left)	0.4	1.1	3.4	-0.8	-1.9	-1.4	0.0	-1.7	-1.0	-0.5	-0.7	-0.9	0.6	-0.2
Number of treatments/medications taken	0.7	1.2	3.4	1.4	0.9	0.2	0.2	1.6	0.9	1.8	1.2	0.7	-0.3	1.4
Average weekly spirits intake	1.2	1.5	4.0	-1.2	-1.3	-0.2	-0.2	-0.3	-1.6	-1.2	-1.7	-1.4	2.0	-0.8
Sensitivity / hurt feelings	0.3	0.5	2.5	-0.8	-0.0	0.0	-1.6	-0.6	-0.7	-0.3	-0.3	-0.7	0.2	-0.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.5	-1.2	-0.2	0.2	-1.0	0.1	-0.3	-0.6	-0.1	-0.5	0.2	-1.0
Hearing difficulty/problems: Yes	0.3	0.5	2.0	-0.5	-0.3	1.4	0.6	-0.0	0.6	0.8	0.9	0.4	-0.7	0.9
Relative age of first facial hair	1.1	2.3	7.4	-0.7	-1.3	-2.7	-0.3	0.8	-2.1	-0.7	-1.8	-1.7	1.3	-1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.4	0.0	-1.6	-0.4	0.4	1.1	-1.0	0.4	-0.8	-1.1	1.2	-0.4
Ever used hormone-replacement therapy (HRT)	1.6	2.0	4.1	-0.9	-2.0	-1.7	-1.4	0.2	-2.0	-1.0	-1.2	-1.9	1.1	-1.1
Ever had hysterectomy (womb removed)	0.7	0.7	2.2	0.1	-1.3	-1.1	-1.5	-0.8	-0.9	-0.3	-0.5	-1.0	0.4	-0.2
Systolic blood pressure, automated reading	1.2	3.5	8.9	-1.2	-1.7	-2.1	0.2	0.9	-2.3	-0.7	-2.6	-2.4	3.0	-1.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.2	0.1	1.3	1.5	-0.8	-0.9	1.1	-0.3	0.7	1.4	-1.4	-0.1
Angina	0.8	1.0	3.2	-1.0	-1.5	-0.5	1.8	0.6	-0.9	-0.3	-0.7	-1.1	1.2	-0.6
Medication for hormone replacement therapy	0.8	0.9	3.2	0.1	-1.2	-1.8	-1.0	0.3	-1.3	0.1	-0.8	-1.1	0.8	-0.3
Vitamin and mineral supplements	1.5	2.1	3.8	0.2	-1.2	-1.4	2.0	1.4	-1.9	-1.0	-1.6	-1.6	1.6	-1.2
Supplements: Zinc	0.3	0.3	1.5	-0.5	0.3	0.2	-0.9	-1.2	-0.6	0.4	0.1	0.1	-0.7	0.3
Medication: Co-codamol	0.4	0.4	1.4	-0.1	-0.5	-1.2	0.1	1.0	-0.7	-0.1	-0.1	-0.8	0.4	-0.7
Medication: Metformin	0.2	0.2	0.7	-0.5	0.5	0.4	0.7	0.3	0.4	0.4	0.3	0.4	-0.8	-0.1
Diabetes (father)	0.5	0.6	2.0	0.7	0.2	0.2	1.0	-0.4	0.7	1.4	1.0	0.5	-0.8	0.9
Diabetes (mother)	0.6	0.7	2.1	0.6	1.5	0.8	-0.9	1.1	0.8	0.6	0.9	0.6	-0.7	0.1
Severe depression (siblings)	0.7	0.8	3.5	-1.2	0.0	0.1	-0.2	-1.9	-0.8	-1.1	-0.9	-0.4	0.3	-1.1
Pack years adult smoking proportion	0.3	0.5	1.1	0.8	-0.8	0.6	-1.1	1.1	0.3	0.4	0.4	-0.2	0.7	0.7
Impedance of leg (right)	0.3	1.4	11.2	0.9	0.5	1.0	-0.6	3.4	-0.3	1.4	-0.2	0.3	-0.2	0.4
Leg fat-free mass (left)	1.0	5.0	17.3	1.4	2.4	0.9	0.1	-4.2	2.1	1.2	2.5	2.3	-2.8	2.0
Trunk fat percentage	3.2	12.8	20.8	3.0	3.4	4.3	-0.3	-1.0	4.0	3.2	4.6	4.3	-4.6	3.8
Hand grip strength (right)	0.9	2.3	6.5	-0.8	-2.2	-2.2	0.2	-2.5	-1.8	-1.0	-1.3	-1.4	0.7	-0.7
Townsend deprivation index at recruitment	1.0	1.5	3.2	-1.7	-0.7	-0.4	-0.5	-0.1	-1.1	-1.8	-1.0	-1.4	1.3	-1.7
Current tobacco smoking	2.4	4.0	6.4	-2.0	-2.5	-1.5	-0.3	0.3	-2.4	-1.9	-2.1	-2.5	2.5	-2.1
Average weekly fortified wine intake	1.1	1.3	4.0	-0.3	-0.1	-0.1	-2.0	-1.6	-1.2	-1.4	-1.5	-0.6	0.6	-1.1
Maternal smoking around birth	0.9	1.3	2.8	-0.8	-1.7	-1.7	-0.3	-0.5	-1.0	-1.6	-0.6	-1.1	0.7	-1.3
Fed-up feelings	0.5	1.0	2.6	-0.8	0.1	-1.1	-1.6	-0.7	-0.7	-1.1	-0.6	-1.1	0.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.8	-1.1	0.1	-0.7	0.5	-1.7	-0.6	-0.8	-0.2	-0.3	-0.5	-1.1
Relative age voice broke	0.1	0.2	0.5	-0.5	-0.1	-0.4	-0.4	-0.1	-0.7	-0.5	-0.2	0.0	-0.6	-0.6
Taking other prescription medications	1.2	1.9	3.4	-0.8	-1.3	-1.3	0.8	1.6	-1.6	-0.7	-1.7	-1.8	1.8	-1.3
Age when periods started (menarche)	0.7	1.8	3.6	-0.5	-1.3	-1.6	1.9	1.5	-1.7	0.1	-1.3	-1.4	1.6	-0.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	7.0	1.1	0.6	0.6	-2.6	-0.6	0.8	0.9	1.0	1.0	-0.8	1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	6.2	0.4	2.4	1.1	0.4	-2.5	1.4	0.4	2.1	1.6	-2.5	0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.3	0.2	0.2	1.5	-0.5	0.6	0.7	0.6	0.6	0.6	-0.3	0.4
Qualifications: CSEs or equivalent	0.3	0.5	1.6	1.2	0.2	0.6	-0.5	-0.8	0.9	-0.0	0.8	0.5	-0.5	0.5
Serious illness, injury or assault to yourself	0.2	0.2	1.3	0.0	-1.1	0.2	-0.2	0.4	-0.5	-0.2	-0.5	-0.4	0.5	-0.1
High blood pressure	1.0	2.8	7.0	2.4	1.6	0.8	0.1	2.0	1.2	2.6	1.6	1.2	-0.6	2.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	7.3	0.8	1.2	0.1	2.7	1.2	0.2	1.2	0.7	0.7	-1.3	1.0
Multivitamins +/- minerals	1.6	2.0	7.5	-0.7	0.3	1.3	-2.2	-2.7	1.6	0.3	1.0	1.2	-1.1	0.9
Stomach or abdominal pain in last month	1.3	1.7	3.6	-1.3	-1.5	-0.9	0.6	-0.9	-1.9	-0.9	-1.6	-1.6	1.2	-1.1
Supplements: Glucosamine	0.9	1.2	2.8	-0.2	1.0	0.9	-0.9	-1.7	1.0	0.5	1.4	1.1	-1.5	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.2	1.1	0.8	0.2	-1.0	-0.5	0.3	-0.5	-0.1	0.3	-0.0	0.1
Medication: Atenolol	1.7	2.1	3.7	1.3	1.9	1.2	-0.5	0.8	1.5	1.6	1.8	1.6	-1.5	1.5
Medication: Levothyroxine sodium	3.9	6.6	11.1	-2.6	-2.6	-2.3	-0.6	-0.1	-3.3	-2.6	-3.2	-3.1	2.5	-3.0
Sitting height	0.3	1.9	14.1	-0.3	1.5	-1.8	0.3	-3.8	-0.5	0.8	-0.3	-0.4	-0.2	-0.1
Chronic bronchitis/emphysema (father)	0.5	0.6	3.1	-0.1	-0.3	-0.2	1.8	-0.9	-0.8	-0.6	-0.2	-0.8	0.4	-0.7
High blood pressure (mother)	0.9	1.3	7.2	0.3	-0.1	0.9	-1.3	2.7	0.3	1.5	0.2	-0.0	0.9	1.0
Body mass index (BMI)	1.1	4.6	10.8	2.0	1.1	2.1	-0.4	-0.7	2.6	1.9	3.3	2.3	-2.4	2.7
Impedance of leg (left)	0.3	1.3	11.0	0.5	0.0	1.2	-0.5	3.3	-0.3	1.1	-0.4	0.3	0.0	0.2
Leg predicted mass (left)	0.9	4.9	18.2	1.4	2.4	0.9	0.0	-4.3	2.0	1.1	2.5	2.2	-2.8	2.0
Trunk fat mass	2.5	10.7	18.8	2.7	3.2	3.4	-0.3	-1.8	3.6	2.9	4.2	3.9	-4.3	3.5
Waist circumference	2.7	9.7	18.3	3.4	2.6	2.9	0.3	-0.7	3.1	3.3	4.3	3.4	-3.8	3.9
Number of incorrect matches in round	0.8	1.3	4.0	-0.9	-0.9	-0.3	2.0	0.5	-0.9	-0.7	-1.2	-1.2	1.7	-1.0
Past tobacco smoking	1.2	2.1	5.3	2.1	0.6	0.8	-1.3	1.8	1.4	2.3	0.9	1.1	-0.1	2.0
Alcohol usually taken with meals	1.1	1.8	3.6	1.2	1.3	0.7	-1.0	-0.5	1.4	1.4	1.8	1.4	-1.9	1.3
Nervous feelings	1.8	3.4	12.2	2.4	1.3	0.8	1.5	3.5	1.2	2.2	1.5	1.5	-1.1	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	2.1	0.6	0.0	-0.2	-0.6	1.5	0.4	0.4	0.6	0.4	-0.4	0.4
Hearing difficulty/problems with background noise	0.4	0.6	2.3	-0.8	-1.1	0.3	1.1	1.5	-0.5	0.4	-0.2	-0.5	0.4	0.1
Hair/balding pattern: Pattern 2	1.5	2.0	5.3	2.3	1.4	-0.6	-0.7	0.6	0.9	1.2	1.9	1.2	-1.9	1.6
Had menopause	2.8	3.5	7.4	-1.9	-2.1	-1.4	-0.4	1.2	-2.0	-1.3	-2.4	-2.4	2.7	-1.6
Had other major operations	0.5	0.6	2.0	-0.2	-1.4	-1.3	0.0	-0.3	-0.9	-0.0	-0.3	-1.1	0.6	-0.0
Forced vital capacity (FVC)	0.5	2.1	4.7	-0.8	-1.6	-1.9	-1.6	0.5	-1.4	0.3	-1.8	-1.8	2.2	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	9.4	0.1	2.4	1.7	0.9	-2.8	1.3	0.0	2.6	1.7	-3.1	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	5.4	-0.3	0.6	1.0	-0.4	-2.3	0.0	0.1	0.2	0.3	-0.8	-0.2
Qualifications: None of the above	0.4	0.9	1.7	-1.0	-1.2	0.2	-1.1	1.3	-0.9	-0.4	-0.6	-1.1	1.2	-0.5
Financial difficulties in last 2 years	0.6	0.8	2.9	0.5	0.6	0.7	0.4	-0.4	0.9	1.7	1.0	0.7	-0.8	1.3
Mouth/teeth dental problems	0.4	0.7	4.1	-0.0	-0.3	-0.4	1.4	-2.0	0.0	-0.8	-0.1	-0.1	0.1	-0.4
Heart attack	1.7	2.2	3.5	-1.1	-1.0	-1.4	1.6	-0.8	-1.7	-1.9	-1.6	-1.7	1.4	-1.9
Allergy	1.6	3.6	5.0	-2.0	-2.1	-1.4	-0.9	-1.7	-1.6	-2.2	-2.1	-2.0	2.2	-2.2
Pain all over the body in last month	1.2	1.2	3.1	-1.0	-1.1	-1.1	-0.1	-0.1	-1.8	-0.5	-1.2	-1.5	1.2	-1.1
Diabetes (self-reported)	1.1	1.7	3.4	0.9	1.3	1.1	0.9	1.8	1.4	1.6	1.3	1.4	-1.1	1.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	0.3	0.3	-0.4	-0.0	0.7	-0.4	0.3	0.0	-0.2	-0.1	0.1
Medication: Ramipril	0.1	0.2	0.6	0.8	0.1	-0.4	-0.2	0.8	-0.5	0.1	0.2	-0.4	0.2	-0.0
Medication: Simvastatin	1.5	2.3	9.1	1.6	0.6	1.1	0.2	3.0	0.9	2.2	1.2	1.0	-0.6	1.7
Fluid intelligence score	0.3	0.6	2.1	0.3	0.0	-1.5	-0.2	0.7	-0.8	0.1	-0.9	-1.1	1.1	-0.7
Illnesses of siblings	0.7	1.0	5.5	-0.7	0.9	1.1	-0.3	-2.4	0.8	-0.6	0.5	0.9	-1.0	-0.3
Neuroticism score	0.1	0.3	1.4	0.8	0.7	-0.2	-0.6	1.2	0.0	0.2	0.3	0.0	-0.4	-0.2
Weight	1.3	6.5	11.4	2.1	2.3	1.9	-0.0	-2.9	2.6	2.2	3.4	2.8	-3.3	2.9
Impedance of arm (right)	0.2	0.8	3.6	-0.5	1.9	1.6	0.1	0.4	-0.1	-0.0	-0.5	0.5	-0.7	-1.0
Arm fat percentage (right)	1.8	7.2	12.8	2.0	2.4	3.5	-0.4	-0.5	3.2	2.3	3.6	3.2	-3.3	2.8
Trunk fat-free mass	0.3	1.8	13.0	0.3	1.1	-0.6	0.1	-3.6	0.5	0.2	1.1	0.6	-1.5	0.9
Hip circumference	1.8	8.0	14.7	2.6	2.6	2.7	-0.9	-2.0	2.8	2.5	3.8	3.0	-3.6	3.2
Time employed in main current job	1.0	1.2	2.9	1.1	0.4	0.9	-1.7	-0.7	1.2	0.5	1.0	1.3	-1.3	1.0
Alcohol intake versus 10 years previously	0.3	0.5	4.1	0.1	0.2	0.5	0.3	2.0	0.6	0.5	0.1	0.1	0.5	0.3
Father’s age at death	0.3	0.4	2.0	-0.7	0.2	0.3	1.4	-0.2	0.4	-1.0	0.2	-0.0	-0.6	-0.6
Worrier / anxious feelings	0.3	0.6	2.3	0.6	0.5	0.2	-0.3	1.2	0.6	1.5	0.8	0.6	-0.6	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.7	0.1	-0.0	-0.0	-0.8	0.7	-0.1	-0.1	-0.0	-0.3	0.3	-0.3
Falls in the last year	0.1	0.1	0.3	-0.3	-0.3	-0.4	-0.1	0.2	-0.4	-0.4	-0.3	-0.5	0.2	-0.6
Hair/balding pattern: Pattern 3	1.9	2.9	7.3	-2.1	-1.7	-0.1	1.5	-0.8	-0.8	-2.4	-1.6	-1.4	1.8	-2.7
Number of live births	0.7	1.0	2.3	1.4	0.7	0.3	-0.0	-1.0	0.6	1.1	1.2	1.0	-1.5	1.3
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.9	-0.7	-1.0	-1.7	-1.0	-0.1	-0.8	-0.0	-1.0	-1.1	1.3	-0.7
Pulse rate	0.7	1.3	3.3	1.8	1.5	0.7	-0.7	0.4	1.7	0.6	1.1	1.2	-0.5	1.0
Happiness	0.4	0.5	2.0	-1.2	0.4	1.1	1.4	0.5	-0.0	0.3	0.3	-0.4	0.7	-0.3
Noisy workplace	0.2	0.2	1.1	0.6	0.5	0.2	-1.1	0.1	0.2	-0.2	0.6	0.1	-0.2	0.2
Qualifications: A levels/AS levels or equivalent	1.9	4.2	9.2	2.3	1.6	0.4	1.9	0.5	1.6	3.0	1.8	2.4	-2.2	3.0
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	4.4	1.7	1.4	0.3	-0.4	0.2	0.9	2.0	1.7	1.6	-2.0	2.1
Mouth/teeth dental problems: Dentures	0.7	1.2	2.9	0.9	1.7	0.7	-0.4	1.1	1.3	0.6	1.3	1.2	-1.3	0.7
Asthma	2.0	4.0	6.8	2.1	1.4	2.0	-1.2	1.9	1.9	2.6	2.3	1.9	-1.8	2.5
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	6.2	-0.0	1.7	1.8	0.3	-0.9	1.8	1.1	2.4	1.8	-2.5	1.2
Medication: Cholesterol lowering	0.2	0.3	1.3	0.2	0.5	0.4	0.6	1.1	0.6	0.6	0.5	0.4	-0.2	0.2
Depression (self-reported)	0.2	0.2	0.7	-0.2	-0.3	-0.8	-0.7	-0.5	-0.6	-0.2	-0.1	-0.4	0.0	-0.3
Medication: Lansoprazole	1.1	1.3	5.1	0.4	-1.3	-0.3	-1.9	2.2	-0.1	0.7	-0.5	-0.7	1.5	0.3
Prospective memory result	0.4	0.5	1.4	-0.1	1.0	0.5	0.5	-0.3	0.9	-0.2	0.6	1.0	-1.2	-0.0
Lung cancer (father)	2.5	2.9	5.1	0.5	2.1	2.2	0.2	-0.8	2.3	1.5	2.2	2.0	-2.1	1.2
Illnesses of mother	0.8	1.0	6.2	-0.7	0.3	0.1	1.0	-2.5	-0.7	-1.3	-0.4	-0.0	-0.9	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.8	-1.3	-1.2	-1.7	-1.3	-0.8	-1.1	-0.2	-1.0	-1.4	1.3	-0.9
Pulse wave Arterial Stiffness index	0.6	0.7	2.0	-0.3	-0.2	-1.4	0.0	0.8	-1.3	-0.1	-0.9	-1.1	0.6	-0.9
Impedance of arm (left)	0.3	1.6	5.3	0.2	2.3	2.2	0.8	0.4	0.8	0.7	0.5	1.5	-1.6	-0.0
Arm fat mass (right)	1.6	6.7	12.5	2.2	2.3	2.5	-0.3	-1.5	2.9	2.3	3.5	2.9	-3.3	3.0
Trunk predicted mass	0.3	1.7	12.9	0.3	1.1	-0.6	0.1	-3.6	0.4	0.1	1.0	0.6	-1.4	0.9
Standing height	0.4	3.6	26.3	0.2	2.5	-0.7	0.8	-5.1	-0.0	0.6	0.4	0.9	-2.0	0.6
Length of working week for main job	0.9	1.0	2.5	1.0	-0.4	0.8	0.0	-0.7	1.2	0.8	1.6	1.0	-1.3	1.2
Exposure to tobacco smoke at home	1.0	1.1	2.0	-1.3	-1.1	-0.6	1.4	-0.8	-1.1	-1.3	-1.0	-1.1	0.6	-1.0
Breastfed as a baby	1.6	2.0	5.0	2.2	0.4	-0.3	-0.6	1.2	0.9	1.9	1.8	1.0	-1.2	2.2
Tense / ‘highly strung’	0.4	0.6	2.8	0.4	0.7	0.1	1.7	1.1	0.4	0.8	0.7	0.4	-0.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.7	-0.5	0.2	-0.5	0.3	0.2	-0.9	-0.3	-0.3	-0.3	-0.3	-0.7
Hair/balding pattern: Pattern 4	0.9	2.1	6.9	-1.8	-1.0	0.6	-0.4	-2.6	0.5	-2.2	-0.8	-0.8	1.4	-1.8
Birth weight of first child	1.2	2.2	4.9	1.7	1.0	-0.2	1.8	-0.8	1.8	0.8	2.2	1.7	-1.7	1.3
Peak expiratory flow (PEF)	0.3	0.6	2.0	-1.4	-1.2	-0.8	0.4	-1.2	-0.0	-0.3	-0.1	-0.6	0.6	-0.6
Pulse wave reflection index	0.5	0.6	1.3	-0.8	-0.4	-1.0	1.1	1.2	-0.6	-0.0	-0.5	-0.6	0.4	-0.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.4	-0.6	0.3	0.3	-1.6	-1.0	-0.7	-1.2	-0.5	-0.4	-0.4	-1.1
Loud music exposure frequency	1.3	1.4	3.2	-1.2	-1.6	-0.6	-0.4	0.5	-0.6	-1.2	-1.4	-1.2	1.8	-1.4
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	6.8	1.8	2.6	1.6	0.0	1.3	1.9	1.5	1.3	2.2	-1.8	1.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.1	-1.3	-1.4	-0.2	-0.4	1.5	-0.8	-0.0	-0.9	-0.9	0.9	-0.4
Blood clot in the leg (DVT)	0.2	0.3	1.0	-0.2	0.9	-0.0	0.7	-0.3	0.4	-0.3	0.7	0.5	-1.0	-0.2
Medication: Paracetamol	2.8	4.6	7.5	1.9	1.8	1.9	-1.1	0.6	2.4	2.6	2.6	2.4	-2.3	2.7
Headache pain in last month	5.1	8.7	16.0	2.9	2.3	2.7	-0.4	0.5	3.9	3.3	4.0	3.4	-3.0	3.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.5	-1.2	-0.3	0.8	-1.2	-1.6	-0.6	-1.1	-0.8	-0.3	0.1	-0.7
Glaucoma (self-reported)	1.8	2.2	4.2	-0.8	-1.4	-1.6	0.1	-0.5	-1.6	-1.6	-1.8	-1.9	2.1	-1.4
Gout (self-reported)	1.2	1.6	4.2	-0.6	-2.1	-1.1	2.0	-0.8	-0.4	-0.8	-1.3	-1.0	1.8	-0.6
Hypothyroidism/myxoedema (self-reported)	3.8	7.5	12.3	-3.0	-3.1	-1.9	0.1	-1.1	-3.5	-2.9	-3.5	-3.1	2.7	-3.0
Medication: Amlodipine	1.7	2.3	5.1	1.7	1.2	0.2	-0.1	1.4	1.8	2.3	1.9	1.4	-1.0	2.1
Medication: Ventolin 100micrograms inhaler	1.8	2.3	3.8	1.6	1.2	1.6	-2.0	0.5	1.7	1.5	1.6	1.5	-1.1	1.8
Birth weight	1.2	2.6	5.9	-0.3	1.8	1.0	-1.1	-2.4	1.7	0.9	1.7	1.9	-2.3	1.0
Chronic bronchitis/emphysema (mother)	1.1	1.3	6.3	-0.7	0.9	0.2	-2.0	-2.5	0.1	-0.9	0.4	0.1	-1.1	-0.8
High blood pressure (siblings)	0.9	1.4	8.1	0.9	-0.8	-0.8	-0.1	2.8	-0.1	1.3	0.0	-0.6	1.2	1.0
Forced vital capacity (FVC), Best measure	0.5	2.0	3.6	-1.1	-1.7	-1.9	-1.8	-0.3	-1.4	0.3	-1.5	-1.7	1.8	-0.7
Body fat percentage	2.9	11.6	19.5	2.9	2.9	4.1	-0.5	-0.3	3.9	3.2	4.4	4.1	-4.2	3.8
Leg fat percentage (right)	2.1	7.6	13.4	2.8	1.8	3.2	-0.7	0.9	2.9	2.9	3.7	3.0	-3.0	3.4
Arm fat-free mass (right)	0.6	3.3	12.6	1.3	1.3	0.2	-0.1	-3.5	1.6	1.1	2.0	1.7	-2.3	2.1
Exposure to tobacco smoke outside home	0.9	1.1	2.3	1.1	1.5	0.6	-1.1	-1.3	1.1	0.2	1.2	1.0	-1.4	0.3
Comparative body size at age 10	0.5	1.5	4.6	1.2	0.3	1.1	-2.1	-0.4	1.9	0.6	1.4	1.1	-0.8	1.1
Number of full brothers	0.3	0.4	2.0	-1.0	0.2	1.4	0.5	0.9	-0.1	0.2	0.2	0.1	-0.1	0.2
Worry too long after embarrassment	1.6	2.7	5.0	1.4	1.3	1.4	-0.5	0.4	1.5	2.2	2.2	1.8	-2.1	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.3	1.0	-0.1	-1.1	-0.1	0.9	-0.5	0.3	0.3	-0.3	-0.5	-0.1
Wheeze or whistling in the chest in last year	0.9	1.7	3.6	1.2	0.7	1.9	0.2	0.7	1.1	1.6	1.4	1.4	-1.4	1.6
Number of children fathered	0.4	0.4	1.5	0.3	-0.0	-0.1	0.8	-1.2	0.4	0.2	0.6	0.5	-0.9	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.1	-0.9	0.3	0.1	-0.6	-1.0	-0.5	-0.7	-0.9	-0.8	0.7	-1.0
Age at first live birth	1.0	1.8	4.1	1.1	1.6	1.0	0.8	-0.1	1.4	0.6	1.8	1.7	-2.0	1.2
Pulse wave peak to peak time	0.4	0.5	1.7	0.0	0.2	1.0	-0.2	-1.3	1.1	-0.3	0.6	0.8	-0.4	0.4
Health satisfaction	0.3	0.3	1.4	0.1	0.1	1.2	-0.1	1.2	0.6	0.4	0.4	0.2	0.3	0.4
Shortness of breath walking on level ground	1.0	1.2	2.7	1.3	1.4	1.6	-1.3	0.4	1.2	0.3	1.2	1.2	-0.9	0.6
Qualifications: College or University degree	0.2	0.5	3.1	-0.2	-0.2	-1.8	0.9	-0.6	-1.0	-0.0	-0.5	-0.4	-0.1	-0.0
Eye problems/disorders: None of the above	0.5	0.6	2.4	-0.2	1.2	0.0	0.1	-0.0	0.5	0.4	1.0	0.9	-1.6	0.4
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.2	-0.9	-0.4	-0.1	-1.3	-1.2	-1.5	-0.9	-0.4	-1.3	0.4	-0.5
Emphysema/chronic bronchitis	0.6	0.7	4.2	0.3	-0.6	-0.4	-2.0	1.4	-0.5	0.0	-0.1	-0.7	0.5	-0.0
Medication for pain relief, constipation, heartburn	0.4	0.8	2.0	-0.4	-0.6	-0.7	-0.5	0.4	-1.1	-0.9	-1.4	-0.7	0.9	-1.2
Neck or shoulder pain in last month	2.2	3.1	17.0	1.6	-1.1	0.0	-0.2	4.1	1.1	2.3	0.8	0.2	1.1	2.2
Medication: Blood pressure	1.0	1.7	3.2	1.7	1.2	-0.4	1.8	0.9	1.2	1.7	1.4	1.1	-0.8	1.4
Angina (self-reported)	0.9	1.1	3.3	-1.0	-1.6	-0.3	1.8	0.7	-1.0	-0.3	-0.7	-1.2	1.3	-0.7
Migraine (self-reported)	0.9	1.2	2.8	1.0	1.7	0.9	-0.8	0.9	1.4	1.1	1.1	1.2	-0.9	0.6
Medication: Ibuprofen	3.0	3.6	8.3	0.8	1.8	1.1	0.3	-0.6	2.0	2.1	2.9	2.1	-2.8	2.2
Medication: Allopurinol	0.7	1.0	2.9	-0.8	-1.7	-0.3	1.7	-0.4	-0.1	-1.2	-0.9	-0.6	1.1	-0.6
Medication: Omeprazole	4.2	5.1	9.6	-2.0	-2.6	-2.0	-0.5	-0.5	-3.1	-2.2	-2.6	-3.0	2.4	-2.1
Medication: Seretide 50 evohaler	1.2	1.4	2.6	1.2	1.3	0.9	-0.4	0.5	1.3	1.6	1.4	1.1	-1.3	1.4
Mean time to correctly identify matches	0.7	1.4	3.1	-1.5	-0.4	-0.6	1.1	-0.0	-1.0	-1.8	-1.4	-1.1	1.1	-1.6
Heart disease (mother)	1.1	1.4	2.7	-0.1	-1.5	-1.3	0.4	1.5	-1.4	-0.1	-1.2	-1.4	1.6	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.4	6.4	10.2	-2.9	-3.2	-2.5	0.2	-0.5	-3.0	-2.5	-2.9	-2.8	2.6	-2.5
Whole body fat mass	2.5	10.4	17.6	2.8	2.9	3.4	-0.7	-1.4	3.6	2.9	4.2	3.8	-4.1	3.7
Leg fat mass (right)	1.8	7.1	13.2	2.7	2.0	2.6	-0.6	-0.6	2.9	2.6	3.6	3.0	-3.2	3.4
Arm predicted mass (right)	0.5	2.6	10.2	1.3	1.0	0.2	0.0	-3.2	1.3	1.1	1.9	1.4	-1.9	2.0
Pulse rate, automated reading	0.1	0.4	1.4	0.1	0.7	0.4	-0.5	1.2	0.5	-0.7	-0.4	-0.2	1.0	-0.5
Alcohol intake frequency.	2.4	5.5	9.5	2.4	1.5	2.7	-0.2	2.5	3.1	2.6	2.8	2.5	-1.3	2.5
Comparative height size at age 10	0.3	1.8	13.8	-1.0	1.5	0.3	0.7	-3.7	-0.1	-0.5	-0.1	0.4	-1.2	-0.3
Number of full sisters	0.3	0.4	0.8	-0.3	-0.0	0.8	0.9	0.0	-0.9	-0.8	-0.6	-0.5	0.4	-0.7
Suffer from ‘nerves’	0.7	1.1	3.1	0.4	-1.3	-1.8	0.8	1.7	-1.1	-0.2	-0.5	-1.0	0.8	-0.6
Overall health rating	0.1	0.2	1.4	0.4	-0.1	0.2	0.4	1.2	0.1	0.4	0.3	-0.3	0.1	0.0
Chest pain or discomfort	0.3	0.4	1.1	0.2	0.7	1.0	-0.0	0.9	0.6	1.1	0.7	0.4	-0.1	0.4
Had major operations	1.2	1.4	3.6	0.1	-1.5	-1.5	0.7	0.4	-1.9	-1.2	-1.3	-1.3	0.7	-1.2
Age at last live birth	2.5	3.6	7.0	1.0	1.8	1.7	1.4	-0.5	2.3	1.5	2.5	2.4	-2.7	1.9
Family relationship satisfaction	1.6	2.0	3.9	-2.0	-0.7	-1.1	1.9	-0.4	-1.5	-1.5	-1.3	-1.5	1.1	-1.7
Leg pain on walking	0.8	1.0	2.4	0.8	1.0	0.9	-1.4	1.5	0.3	0.9	0.9	0.7	-1.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.0	1.3	0.9	-0.1	-1.4	0.3	0.9	0.9	1.3	0.7	-0.9	0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.8	-0.1	-0.6	0.6	-0.9	-0.7	0.2	-0.8	-0.1	-0.0	0.5	-0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	-0.5	0.4	0.2	-0.5	-0.5	0.2	-0.7	-0.1	-0.2	0.4	-0.5
Medication: Aspirin	0.1	0.2	0.9	0.4	0.4	0.1	1.0	0.3	0.5	-0.2	-0.1	0.1	0.3	-0.2
Supplements: Vitamin C	0.4	0.4	1.6	-0.3	1.3	1.0	0.3	-0.1	0.3	0.4	0.3	0.8	-0.9	0.4
Knee pain experienced in last month	1.1	1.8	4.6	-2.1	-0.6	0.2	-0.7	-1.6	-1.6	-1.5	-1.5	-1.4	0.7	-1.4
Hypertension (Self-reported)	1.0	2.8	6.5	2.3	1.9	0.9	-0.2	1.8	1.4	2.5	1.6	1.3	-0.8	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.6	6.2	-2.1	-0.9	-1.6	-1.2	-2.0	-2.1	-2.1	-1.9	-2.3	1.5	-2.5
Illnesses of father: Heart disease	0.6	0.8	3.7	0.5	0.2	-0.2	1.9	0.7	0.8	1.2	0.5	0.9	-0.4	1.1
Illnesses of siblings: Diabetes	0.1	0.1	0.5	-0.2	-0.0	0.7	-0.1	-0.5	-0.6	0.3	-0.1	-0.1	-0.1	0.2
Smoking status: Previous	0.2	0.4	1.4	-0.5	0.3	0.0	1.2	-0.8	0.1	-0.6	0.3	0.2	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	9.0	-0.2	0.6	-1.2	0.1	-3.0	-0.8	0.2	-0.5	-0.4	0.0	0.1
Whole body fat-free mass	0.5	2.9	15.4	0.8	1.6	0.1	0.1	-3.9	1.2	0.7	1.7	1.4	-2.1	1.5
Leg fat-free mass (right)	0.8	4.1	20.0	0.9	2.0	0.7	0.0	-4.5	1.8	0.7	2.0	1.9	-2.4	1.6
Arm fat percentage (left)	2.3	9.0	15.7	2.4	2.6	3.8	-0.1	-0.6	3.6	2.6	4.0	3.6	-3.7	3.2
Average weekly red wine intake	0.6	0.9	2.4	-1.1	0.4	0.5	0.5	-1.5	-0.5	-1.4	-0.5	-0.1	-0.8	-1.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.5	-0.4	0.4	-0.7	0.2	1.2	-0.7	-0.2	-1.0	-0.9	0.8	-1.2
Mood swings	0.3	0.6	2.1	0.1	-0.1	-1.1	-1.5	-0.4	-0.9	-0.7	-0.3	-1.0	0.0	-1.0
Loneliness, isolation	0.5	0.7	2.0	-1.2	-0.4	-0.2	0.3	0.5	-0.8	-1.4	-0.6	-0.9	0.7	-1.4
Long-standing illness, disability or infirmity	0.3	0.4	1.5	0.8	0.5	-1.2	0.6	1.2	-0.3	0.7	-0.1	-0.3	0.0	0.1
Ever had bowel cancer screening	0.3	0.4	1.5	0.3	0.1	1.2	0.2	-0.3	0.3	0.6	0.1	0.7	-0.7	0.9
Diabetes diagnosed by doctor	0.5	0.9	1.8	0.8	1.1	0.4	-0.0	0.9	1.0	1.3	0.9	1.2	-1.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.3	0.1	0.3	0.5	-0.1	0.5	0.8	0.5	0.4	-0.4	0.4
Friendships satisfaction	0.9	1.1	3.7	0.4	1.7	1.1	1.9	-0.9	0.3	0.3	0.8	0.7	-1.3	0.5
Qualifications: nursing, teaching	0.1	0.1	0.2	0.3	0.2	0.5	-0.4	-0.3	0.3	0.1	0.2	0.3	-0.4	0.3
Commuting to job workplace: Walk	1.5	1.6	7.8	1.2	0.8	-0.1	0.7	2.8	0.7	1.6	1.1	0.8	-0.7	1.3
Eye problems/disorders: Cataract	0.9	1.1	4.0	-0.6	-2.0	-0.8	0.6	-0.9	-0.8	-0.6	-1.1	-1.0	1.6	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	-1.1	-0.6	0.2	-1.1	1.3	-0.8	0.1	-0.8	-0.6	0.8	-0.3
Medication for cholesterol	2.5	3.8	9.5	-2.6	-1.4	-1.5	0.5	-2.5	-1.3	-3.1	-1.9	-1.5	0.8	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.2	0.3	1.3	2.0	-1.4	0.1	1.4	0.6	1.3	1.0	-1.1	0.5
Back pain experienced in last month	0.6	0.8	4.2	-0.1	0.2	0.2	-2.0	1.8	0.4	0.7	0.8	0.0	-0.4	0.5
Mineral and other dietary supplements	0.4	0.6	2.5	0.5	0.3	-0.4	1.6	1.4	-0.9	0.0	-0.6	-0.3	0.2	-0.4
Breast cancer (self-reported)	1.0	1.2	2.6	-0.7	-1.3	-1.6	-1.1	0.2	-1.1	-1.1	-1.0	-1.1	1.2	-0.9
Asthma (self-reported)	1.8	3.6	6.3	2.0	1.4	1.7	-1.1	1.5	1.9	2.5	2.2	1.8	-1.7	2.4
Osteoporosis (self-reported)	0.6	0.7	1.8	0.9	-0.6	-1.1	-0.3	1.3	-1.1	0.7	-0.8	-0.7	0.7	0.5
Osteoarthritis (self-reported)	0.7	0.9	2.2	0.5	0.0	-0.1	-1.2	0.2	0.8	1.5	1.2	0.9	-1.0	1.3
Medication: Aspirin	0.2	0.2	1.0	0.5	0.3	0.3	1.0	0.4	0.7	0.2	0.0	0.3	0.3	0.1
Medication: Gliclazide	0.7	0.8	3.7	0.5	1.0	0.3	-1.9	-0.0	0.7	0.7	0.9	0.6	-0.9	0.7
Illnesses of father: None of the above (group 1)	1.2	1.5	4.8	0.3	1.0	1.6	-2.2	0.4	1.2	1.4	0.9	1.1	-0.8	1.2
Smoking status: Current	2.7	4.3	6.7	-2.4	-2.3	-1.3	-0.4	-0.4	-2.6	-2.2	-2.2	-2.6	2.3	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	4.8	-0.9	-2.2	-2.0	-1.2	1.2	-2.0	0.1	-1.1	-2.0	2.0	-0.5
Whole body water mass	0.5	3.1	16.3	0.8	1.6	0.1	0.1	-4.0	1.3	0.6	1.8	1.4	-2.1	1.5
Leg predicted mass (right)	0.8	4.1	19.9	1.0	1.9	0.7	0.2	-4.5	1.8	0.7	2.1	1.9	-2.4	1.6
Arm fat mass (left)	2.1	8.8	16.0	2.6	2.6	2.9	-0.2	-1.6	3.3	2.7	4.0	3.5	-3.8	3.4
Number of self-reported non-cancer illnesses	0.3	0.6	2.5	0.3	0.0	-0.8	-0.6	1.6	-0.7	1.1	-0.0	-0.6	0.5	0.5
Average weekly champagne plus white wine intake	2.9	4.0	11.7	1.5	1.6	0.9	-1.7	-0.8	2.2	1.4	2.7	2.4	-3.4	1.8
Miserableness	0.6	1.0	2.5	-0.4	-0.1	-1.4	-1.6	0.1	-1.0	-0.8	-0.9	-1.2	0.7	-1.3
Guilty feelings	0.3	0.4	1.1	0.2	0.7	0.8	0.3	-0.0	0.5	1.0	0.5	0.6	-1.0	0.4
Wears glasses or contact lenses	0.5	0.5	4.2	-0.7	0.0	0.8	2.1	0.6	0.2	0.2	-0.1	0.2	0.1	-0.1
Ever taken oral contraceptive pill	0.6	0.7	1.3	-0.6	-1.0	-1.1	0.7	0.0	-1.1	-0.6	-0.8	-0.9	0.8	-0.9
Hearing aid user	0.3	0.3	1.0	0.5	-0.5	-0.5	0.8	0.3	-0.3	1.0	0.2	-0.3	-0.0	0.8
Mother’s age at death	0.2	0.3	1.1	0.3	-0.2	0.5	-0.8	-0.5	0.5	-1.1	-0.0	0.1	0.3	-0.7
Financial situation satisfaction	1.8	2.3	5.1	1.1	2.3	1.8	0.8	0.8	2.0	0.9	1.8	1.8	-1.6	0.6
Tinnitus: Yes, now most or all of the time	1.9	2.3	3.5	1.3	1.2	1.1	1.2	1.5	1.8	1.9	1.6	1.8	-1.2	1.8
Commuting to job workplace: Public transport	1.0	1.2	3.5	-0.6	-0.5	-1.7	1.9	0.5	-1.3	-0.1	-1.2	-1.0	0.7	-0.9
Eye problems/disorders: Glaucoma	0.2	0.3	1.3	0.3	-0.3	0.1	0.2	0.8	-0.3	-0.2	-0.4	-0.7	1.1	-0.1
Medication: Blood pressure	1.9	3.6	6.8	1.7	2.1	2.6	-0.8	2.6	1.5	2.6	1.5	1.5	-0.6	2.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.9	0.3	-0.2	0.2	-1.0	0.5	-0.0	-0.1	0.1	-0.1	0.3	0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.5	-0.1	0.2	0.5	-0.8	-0.5	1.2	0.6	1.1	0.9	-0.8	0.9
High cholesterol (Self-reported)	2.5	4.5	15.8	2.4	1.1	0.7	-0.6	4.0	1.5	3.5	1.7	1.4	-0.7	2.5
Medication: Bendroflumethiazide	4.3	6.5	11.0	3.3	3.1	2.0	-0.6	-0.4	2.7	2.8	2.8	2.9	-2.4	3.0
Medication: Paracetamol	3.8	5.8	10.1	2.4	2.4	1.7	-0.9	0.4	3.0	2.7	3.2	2.8	-2.5	2.9
Medication: Lisinopril	1.0	1.2	3.6	1.2	1.5	1.1	-0.2	0.8	1.9	1.0	1.1	1.2	-0.4	0.7
Medication: Atorvastatin	0.5	0.6	2.4	0.7	-0.8	-0.9	0.9	1.6	-0.3	0.4	-0.3	-0.5	0.9	0.2
Illnesses of father: High blood pressure	0.7	0.8	2.5	-0.1	-1.5	-0.9	-0.4	-0.1	-0.7	-0.7	-0.8	-1.1	1.6	-0.8
Alcohol drinker status: Never	0.5	0.5	1.3	0.2	0.7	1.0	-1.1	-0.3	0.7	0.6	0.8	0.8	-0.7	0.6
Ever smoked	1.3	2.3	5.9	-2.4	-0.7	-0.8	1.6	-1.0	-1.5	-2.3	-1.2	-1.2	0.5	-2.0
Basal metabolic rate	0.8	4.2	14.6	1.3	2.1	0.7	-0.0	-3.8	1.8	1.2	2.4	2.0	-2.7	2.0
Leg fat percentage (left)	1.8	6.6	11.6	2.4	1.5	3.3	-0.6	0.8	2.8	2.6	3.4	2.9	-2.8	3.2
Arm fat-free mass (left)	0.5	2.4	9.0	1.2	1.2	0.1	-0.6	-3.0	1.3	0.9	1.9	1.3	-1.9	1.8
Number of operations (self-reported)	0.1	0.2	0.7	-0.2	-0.8	0.1	-0.5	0.3	-0.7	0.1	-0.0	-0.7	0.3	-0.2
Average weekly beer plus cider intake	3.1	4.4	10.0	-1.8	-3.1	-1.6	0.8	1.6	-2.1	-1.5	-2.1	-2.5	3.2	-1.7
Irritability	0.2	0.3	0.9	-0.3	0.8	0.6	-0.8	-0.0	-0.0	-0.8	0.2	-0.2	-0.4	-0.9
Risk taking	0.6	0.9	4.1	-1.4	-0.4	0.7	0.2	-2.0	-0.5	-1.3	-0.2	-0.5	-0.3	-0.9
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.1	0.8	1.4	1.0	-0.5	-1.7	1.4	1.5	1.5	1.8	-1.7	1.7
Fractured/broken bones in last 5 years	0.5	0.7	3.2	-0.7	0.0	0.7	-1.8	0.9	-0.6	-0.3	-0.9	-0.6	0.9	-0.7
Age started oral contraceptive pill	0.4	0.5	2.1	0.7	0.5	0.1	0.2	1.4	0.5	0.7	0.5	0.5	-0.2	1.0
Diastolic blood pressure, automated reading	1.3	3.9	12.3	-1.0	-1.8	-1.7	-0.7	1.2	-2.5	-0.7	-2.6	-2.6	3.5	-1.3
Ever depressed for a whole week	0.4	0.5	1.3	-1.1	0.0	0.9	-0.4	-0.9	-0.3	-0.7	-0.4	-0.3	-0.0	-1.0
Unable to work because of sickness or disability	0.2	0.2	0.7	0.5	-0.6	0.8	0.2	0.1	-0.3	0.5	-0.1	0.0	0.4	0.6
Commuting to job workplace: Cycle	1.2	1.5	9.9	0.0	0.1	1.1	3.1	-0.1	1.1	0.7	1.1	0.9	-0.9	0.8
Myopia	0.6	0.8	1.9	-0.5	0.9	1.3	0.6	0.7	1.4	1.1	1.1	0.8	-0.6	0.5
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.4	-2.1	-1.2	-0.3	-0.4	-1.7	-0.9	-2.0	-1.2	-0.8	0.3	-1.5
Cholesterol lowering medication	3.8	5.6	22.0	3.0	0.6	1.2	-0.1	4.7	1.2	3.7	1.6	1.5	-0.6	2.9
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	6.7	-1.4	-2.0	-1.6	0.1	-0.5	-2.6	-2.0	-2.0	-2.4	1.7	-1.6
Pain experienced in last month	0.3	0.5	2.1	0.1	0.4	-0.4	1.5	-0.8	-0.6	-0.9	-0.6	-0.2	0.2	-0.7
Supplements: Calcium	0.3	0.4	0.9	-0.9	-0.2	-0.5	0.3	-0.6	-0.5	-0.6	-0.8	-0.6	0.6	-0.8
Basal cell carcinoma (self-reported)	2.6	3.1	5.5	2.3	1.3	1.3	0.4	0.6	2.0	2.0	2.0	2.1	-1.8	2.2
Heart attack/myocardial infarction (self-reported)	2.2	2.9	4.5	-1.4	-1.4	-1.4	1.6	-0.7	-2.0	-2.1	-1.8	-2.0	1.6	-2.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.8	0.0	0.8	-0.1	0.5	-0.2	0.3	-0.3	0.7	0.4	-0.9	-0.2
Heart disease (siblings)	0.3	0.3	1.8	0.5	0.7	-0.2	1.3	0.3	0.0	0.3	0.4	0.3	-0.8	0.3
Alcohol drinker status: Previous	0.9	1.1	3.0	0.8	0.7	1.3	-0.1	1.7	1.4	0.6	1.3	0.9	-0.7	0.6
Pack years of smoking	0.2	0.3	0.9	0.7	-0.8	0.5	-0.6	1.0	0.2	0.2	0.2	-0.3	0.7	0.5
Impedance of whole body	0.3	1.4	4.0	0.8	1.6	1.9	0.1	2.0	0.6	1.3	0.4	1.2	-1.1	0.4
Leg fat mass (left)	1.7	6.7	12.3	2.6	1.8	2.6	-0.5	-0.5	2.9	2.5	3.5	3.0	-3.1	3.3
Arm predicted mass (left)	0.6	3.0	9.3	1.1	1.5	0.6	-0.6	-3.0	1.5	1.1	2.0	1.6	-2.2	1.9