Hub : Genes

FBXO42

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0520 0.0220 1.6e-03 0.030 0.020 0.019 0.022 0.020 1.4e-04 1.6e-03 2.0e-03 9.6e-04 1.5e-03
2 GTEx Breast Mammary Tissue 0.1010 0.0420 1.0e-03 0.074 NA 0.020 NA 0.030 1.2e-04 NA 3.1e-02 NA 1.1e-02
3 GTEx Breast Mammary Tissue (Male) 0.1090 0.0712 7.1e-02 0.038 NA 0.036 NA 0.030 4.7e-02 NA 5.1e-02 NA 6.8e-02
4 GTEx Breast Mammary Tissue (Female) 0.0424 0.0448 2.0e-01 -0.010 NA -0.010 NA 0.019 8.7e-01 NA 9.3e-01 NA 8.7e-02
5 GTEx Skin Sun Exposed Lower leg 0.0620 0.0320 8.1e-03 -0.002 NA -0.002 NA -0.001 4.7e-01 NA 4.9e-01 NA 4.1e-01
6 GTEx Testis 0.3050 0.0650 5.9e-10 0.109 NA 0.247 NA 0.253 1.6e-05 NA 2.5e-11 NA 1.4e-11
7 METSIM Adipose 0.0363 0.0148 7.2e-04 0.033 0.011 0.018 0.012 0.025 7.9e-06 6.8e-03 8.8e-04 5.7e-03 8.9e-05
8 ROSMAP Brain Pre-frontal Cortex 0.0944 0.0269 9.1e-10 0.055 0.077 0.089 0.078 0.089 1.2e-07 3.5e-10 1.6e-11 2.8e-10 1.8e-11
9 TCGA Brain Lower Grade Glioma 0.0213 0.0152 7.9e-03 0.004 0.017 0.015 NA 0.009 9.8e-02 4.2e-03 7.5e-03 NA 2.7e-02
10 TCGA Testicular Germ Cell Tumors 0.1730 0.1210 5.6e-03 0.064 0.063 0.036 NA 0.064 2.8e-03 2.9e-03 2.0e-02 NA 2.7e-03
11 TCGA Thyroid Carcinoma 0.0500 0.0240 5.3e-05 0.058 0.052 0.052 NA 0.057 2.7e-06 7.5e-06 7.6e-06 NA 3.2e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.1 0.1 0.3 -0.6 -0.5 0.4 0.0 -0.4 -0.5 -0.4 -0.1 -0.3 0.1 -0.2
Bipolar Disorder or Schizophrenia 1.1 2.7 5.2 -1.0 -2.3 -1.5 0.0 -0.2 -2.0 -1.7 -1.8 -2.2 1.9 -1.6
Depressed Affect (Nagel 2018) 0.5 1.2 2.4 -0.9 -0.5 -1.1 -0.8 -0.8 -1.1 -1.2 -1.1 -1.4 0.8 -1.5
Depression (Nagel 2018) 1.0 1.6 4.6 -1.6 -0.8 -0.5 0.1 -2.1 -1.1 -1.6 -1.0 -1.1 0.4 -1.7
Intelligence (Savage-Jansen 2018) 0.3 1.0 3.1 1.2 1.6 0.1 -0.2 1.3 0.5 1.8 0.7 0.6 -0.6 1.1
Neuroticism (Nagel 2018) 0.0 0.1 0.3 0.2 0.6 0.2 -0.1 -0.1 -0.0 0.4 0.2 0.1 -0.6 -0.1
Schizophrenia (2018) 1.8 3.7 6.4 -0.8 -2.5 -2.2 0.0 0.0 -2.2 -1.9 -2.2 -2.5 2.4 -2.0
Schizophrenia vs Biploar Disorder 1.1 1.5 3.1 -0.8 -0.9 -1.7 0.0 -1.0 -0.8 -1.8 -1.3 -1.2 1.2 -1.6
Worry (Nagel 2018) 0.7 1.4 3.9 1.2 0.4 0.7 1.7 2.0 0.8 1.4 1.0 1.0 -0.9 1.1
Alzheimer’s Disease (in mother) 0.8 0.9 2.3 0.8 0.5 0.0 0.2 1.3 1.1 1.5 1.3 1.0 -0.8 1.1
Alzheimer’s Disease (in father) 0.8 0.9 3.4 -1.4 0.0 0.8 -1.8 0.7 -0.2 -1.5 -0.7 -0.0 0.2 -1.0
Alzheimer’s Disease (including proxy) 0.8 1.2 2.3 0.3 0.8 0.8 -1.2 1.3 1.5 1.0 1.1 1.3 -0.9 1.0
Crohns Disease (2017) 0.5 1.2 2.9 0.8 0.3 0.2 -1.1 -1.3 1.7 0.2 1.4 1.4 -1.2 0.9
Irritable Bowel Disease (IBD) 0.8 1.9 3.8 1.8 0.7 -0.4 -0.6 -1.9 2.0 0.6 1.7 1.6 -1.3 1.4
Ulcerative Colitis (UC) 0.4 0.7 2.4 1.4 0.3 -0.9 0.4 -1.5 1.0 0.2 0.8 0.6 -0.4 0.8
Major Depression (MDD) 0.1 0.1 0.5 -0.3 0.7 0.0 0.0 0.2 0.1 0.1 0.3 -0.1 -0.2 -0.6
Reaction Time 0.6 1.2 3.9 -1.3 -0.7 -0.8 -0.0 -0.6 -0.8 -2.0 -1.2 -1.0 1.1 -1.4
Verbal and Numeric Reasoning (VNR) 0.1 0.3 1.0 0.8 0.9 -0.2 0.6 0.9 0.3 1.0 0.1 0.1 0.2 0.3
Breast Cancer 1.8 4.4 8.4 -1.5 -2.9 -2.3 1.4 -0.9 -2.3 -1.9 -1.9 -2.8 2.5 -1.7
Ovarian Cancer 0.3 0.4 1.4 -1.0 -1.2 1.2 -0.2 -0.5 0.2 -0.5 0.1 0.0 0.0 -0.1
Prostate Cancer 0.8 1.2 3.8 -1.1 1.3 1.8 2.0 -0.6 0.4 0.4 0.4 1.0 -1.1 0.0
Age at First Birth 1.1 1.6 3.5 1.2 1.2 0.1 0.0 -0.7 1.4 0.9 1.4 1.7 -1.9 1.6
Bipolar Disorder (2011) 0.4 0.4 1.7 0.0 -0.1 -0.6 0.0 -0.6 -1.3 0.0 0.0 -1.0 0.2 -1.1
Body Mass Index (BMI) (2010) 1.8 2.4 4.9 0.6 2.2 1.9 0.0 -1.5 1.7 0.9 1.8 1.8 -2.2 0.7
Coronary Artery Disease (CAD) 0.6 0.7 5.1 -0.1 -0.7 0.6 0.0 2.2 0.5 0.6 -0.4 -0.0 1.1 -0.1
Crohns Disease (2012) 0.5 0.7 2.1 0.5 0.9 -0.2 0.0 -1.1 1.4 0.1 1.1 1.1 -1.1 0.4
Mean Putamen Volume 0.8 0.9 5.8 -0.8 -0.8 0.5 -0.3 -2.4 -0.4 -1.0 -0.4 -0.6 0.3 -0.8
Fasting Glucose 0.2 0.3 1.7 0.3 0.6 1.3 0.0 0.8 0.2 0.4 0.1 0.2 -0.3 -0.1
HbA1C 0.6 0.7 3.8 0.7 1.9 0.5 0.0 1.0 1.0 -0.1 0.6 0.6 -0.7 0.1
HDL Cholesterol 0.3 0.5 1.3 0.8 -1.1 -1.1 0.0 0.8 -0.8 0.2 -0.3 -0.7 0.7 -0.0
LDL Cholesterol 0.5 0.8 3.1 -0.0 -1.5 -0.0 0.0 1.3 -0.5 -0.1 -0.8 -0.9 1.8 -0.1
Lupus 0.4 0.6 1.4 1.0 0.9 -0.4 0.3 -0.5 0.8 0.5 1.0 1.0 -1.2 0.6
Neuroticism (2016) 0.5 0.7 2.8 1.3 0.2 -1.7 -0.1 1.0 0.7 1.2 0.6 0.5 -0.2 0.5
Primary Biliary Cirrhosis 1.1 1.5 3.6 1.9 1.1 1.1 0.0 -0.2 1.7 0.8 1.4 1.5 -1.1 1.3
Rheumatoid Arthritis 0.5 0.7 2.2 0.5 -1.5 -0.6 0.0 1.3 -0.7 -0.2 -0.5 -0.9 1.0 -0.1
Schizophrenia (2014) 2.7 5.9 9.4 -1.5 -2.9 -2.6 0.0 0.1 -2.3 -3.0 -2.7 -2.8 3.1 -2.9
Triglycerides 0.5 0.9 2.5 -0.4 -1.2 -0.7 0.0 1.6 -0.8 0.4 -1.1 -1.0 1.4 -0.0
Type 2 Diabetes (T2D) (2012) 1.5 1.7 4.1 1.3 1.8 2.0 0.0 1.0 1.3 1.2 1.4 1.4 -1.2 0.7
Ulcerative Colitis 0.3 0.4 1.5 1.0 0.5 -0.7 0.0 -1.2 0.6 0.1 0.4 0.4 -0.4 0.3
Blood Eosinophil Count 0.5 3.8 13.8 0.7 3.3 1.5 -0.9 -3.7 0.5 1.1 1.1 1.6 -2.9 -0.0
Blood Platelet Count 0.3 3.0 8.3 0.0 2.7 1.7 -1.3 -2.9 1.8 -0.0 1.5 1.7 -1.9 -0.2
Blood Red Count 0.8 7.7 21.0 3.6 3.5 1.8 -1.9 4.6 2.5 3.4 2.3 1.8 -1.2 2.1
Blood White Count 0.1 0.7 3.0 -0.6 0.5 1.2 -1.7 0.3 0.4 -0.3 0.0 -0.3 0.6 -1.2
Heel T-Score 0.6 4.7 13.7 1.2 2.5 0.1 0.3 -2.4 2.2 1.2 3.2 2.5 -3.7 0.8
BMI 1.3 7.4 17.4 2.7 1.0 2.2 -0.2 -1.2 3.0 2.7 4.2 2.9 -3.1 3.8
Height 0.4 7.7 29.5 -2.2 0.5 -3.0 0.7 -5.4 -3.4 -2.4 -3.0 -2.3 0.8 -2.9
Waist Hip Ratio (WHR) 0.9 3.9 7.7 2.4 1.5 1.1 1.6 2.1 1.5 2.8 2.0 1.9 -1.9 2.3
Systolic Blood Pressure 0.6 3.0 12.7 1.0 -0.6 -2.3 0.4 3.6 -0.9 1.8 -1.4 -1.2 2.4 0.7
Smoking Status 1.2 2.9 4.9 -1.8 -2.2 -0.7 0.6 -0.4 -2.1 -2.2 -1.7 -2.0 1.4 -2.0
Allergy or Eczema 0.4 1.1 8.4 0.3 1.0 -0.6 2.9 1.1 -0.7 0.9 -0.1 -0.2 -0.5 0.2
Cardiovascular Disease 1.0 3.4 9.9 2.9 1.5 0.4 0.1 2.8 1.0 3.1 1.3 0.9 -0.5 2.3
Hypothyroidism (self reported) 2.8 6.4 10.4 -2.8 -3.2 -1.8 0.3 -1.6 -3.2 -2.5 -3.1 -2.9 2.2 -2.5
Respiratory disease 3.2 7.0 9.6 2.4 2.8 2.8 -1.6 1.3 2.9 2.8 3.1 3.0 -3.0 2.8
Type 2 Diabetes (T2D) (2018) 0.7 1.2 3.1 0.7 1.5 0.3 1.8 0.3 0.9 1.6 0.7 1.1 -1.2 1.0
Lung FEV1/FVC ratio 0.8 4.2 20.5 -1.7 1.6 -0.0 1.3 -4.5 1.3 -3.1 1.1 0.6 -1.4 -1.9
Lung FVC 1.4 7.0 16.7 -0.9 -4.0 -2.1 -0.7 4.0 -2.3 0.3 -2.2 -3.3 4.1 -1.2
Neuroticism 0.3 0.6 2.1 1.4 1.1 -0.0 0.2 0.5 0.5 0.8 0.8 0.7 -1.0 0.6
Chronotype (morning person) 0.3 0.8 6.1 0.5 0.6 -1.1 2.5 0.5 0.4 0.2 0.4 0.3 -0.2 -0.2
Hair Pigment 0.1 1.6 7.8 -2.8 -0.4 2.2 -1.5 -0.8 0.2 0.8 0.1 0.4 -1.1 0.4
Tanning 0.2 2.1 11.6 -0.9 -0.0 -1.3 1.3 -3.4 -0.5 -2.1 -0.4 -0.4 -0.5 -1.5
Hand grip strength (left) 0.4 1.1 3.4 -0.8 -1.9 -1.4 0.0 -1.7 -1.0 -0.5 -0.7 -0.9 0.6 -0.2
Number of treatments/medications taken 0.7 1.2 3.4 1.4 0.9 0.2 0.2 1.6 0.9 1.8 1.2 0.7 -0.3 1.4
Average weekly spirits intake 1.2 1.5 4.0 -1.2 -1.3 -0.2 -0.2 -0.3 -1.6 -1.2 -1.7 -1.4 2.0 -0.8
Sensitivity / hurt feelings 0.3 0.5 2.5 -0.8 -0.0 0.0 -1.6 -0.6 -0.7 -0.3 -0.3 -0.7 0.2 -0.5
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.5 -1.2 -0.2 0.2 -1.0 0.1 -0.3 -0.6 -0.1 -0.5 0.2 -1.0
Hearing difficulty/problems: Yes 0.3 0.5 2.0 -0.5 -0.3 1.4 0.6 -0.0 0.6 0.8 0.9 0.4 -0.7 0.9
Relative age of first facial hair 1.1 2.3 7.4 -0.7 -1.3 -2.7 -0.3 0.8 -2.1 -0.7 -1.8 -1.7 1.3 -1.3
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.4 0.0 -1.6 -0.4 0.4 1.1 -1.0 0.4 -0.8 -1.1 1.2 -0.4
Ever used hormone-replacement therapy (HRT) 1.6 2.0 4.1 -0.9 -2.0 -1.7 -1.4 0.2 -2.0 -1.0 -1.2 -1.9 1.1 -1.1
Ever had hysterectomy (womb removed) 0.7 0.7 2.2 0.1 -1.3 -1.1 -1.5 -0.8 -0.9 -0.3 -0.5 -1.0 0.4 -0.2
Systolic blood pressure, automated reading 1.2 3.5 8.9 -1.2 -1.7 -2.1 0.2 0.9 -2.3 -0.7 -2.6 -2.4 3.0 -1.2
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.2 0.1 1.3 1.5 -0.8 -0.9 1.1 -0.3 0.7 1.4 -1.4 -0.1
Angina 0.8 1.0 3.2 -1.0 -1.5 -0.5 1.8 0.6 -0.9 -0.3 -0.7 -1.1 1.2 -0.6
Medication for hormone replacement therapy 0.8 0.9 3.2 0.1 -1.2 -1.8 -1.0 0.3 -1.3 0.1 -0.8 -1.1 0.8 -0.3
Vitamin and mineral supplements 1.5 2.1 3.8 0.2 -1.2 -1.4 2.0 1.4 -1.9 -1.0 -1.6 -1.6 1.6 -1.2
Supplements: Zinc 0.3 0.3 1.5 -0.5 0.3 0.2 -0.9 -1.2 -0.6 0.4 0.1 0.1 -0.7 0.3
Medication: Co-codamol 0.4 0.4 1.4 -0.1 -0.5 -1.2 0.1 1.0 -0.7 -0.1 -0.1 -0.8 0.4 -0.7
Medication: Metformin 0.2 0.2 0.7 -0.5 0.5 0.4 0.7 0.3 0.4 0.4 0.3 0.4 -0.8 -0.1
Diabetes (father) 0.5 0.6 2.0 0.7 0.2 0.2 1.0 -0.4 0.7 1.4 1.0 0.5 -0.8 0.9
Diabetes (mother) 0.6 0.7 2.1 0.6 1.5 0.8 -0.9 1.1 0.8 0.6 0.9 0.6 -0.7 0.1
Severe depression (siblings) 0.7 0.8 3.5 -1.2 0.0 0.1 -0.2 -1.9 -0.8 -1.1 -0.9 -0.4 0.3 -1.1
Pack years adult smoking proportion 0.3 0.5 1.1 0.8 -0.8 0.6 -1.1 1.1 0.3 0.4 0.4 -0.2 0.7 0.7
Impedance of leg (right) 0.3 1.4 11.2 0.9 0.5 1.0 -0.6 3.4 -0.3 1.4 -0.2 0.3 -0.2 0.4
Leg fat-free mass (left) 1.0 5.0 17.3 1.4 2.4 0.9 0.1 -4.2 2.1 1.2 2.5 2.3 -2.8 2.0
Trunk fat percentage 3.2 12.8 20.8 3.0 3.4 4.3 -0.3 -1.0 4.0 3.2 4.6 4.3 -4.6 3.8
Hand grip strength (right) 0.9 2.3 6.5 -0.8 -2.2 -2.2 0.2 -2.5 -1.8 -1.0 -1.3 -1.4 0.7 -0.7
Townsend deprivation index at recruitment 1.0 1.5 3.2 -1.7 -0.7 -0.4 -0.5 -0.1 -1.1 -1.8 -1.0 -1.4 1.3 -1.7
Current tobacco smoking 2.4 4.0 6.4 -2.0 -2.5 -1.5 -0.3 0.3 -2.4 -1.9 -2.1 -2.5 2.5 -2.1
Average weekly fortified wine intake 1.1 1.3 4.0 -0.3 -0.1 -0.1 -2.0 -1.6 -1.2 -1.4 -1.5 -0.6 0.6 -1.1
Maternal smoking around birth 0.9 1.3 2.8 -0.8 -1.7 -1.7 -0.3 -0.5 -1.0 -1.6 -0.6 -1.1 0.7 -1.3
Fed-up feelings 0.5 1.0 2.6 -0.8 0.1 -1.1 -1.6 -0.7 -0.7 -1.1 -0.6 -1.1 0.6 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.8 -1.1 0.1 -0.7 0.5 -1.7 -0.6 -0.8 -0.2 -0.3 -0.5 -1.1
Relative age voice broke 0.1 0.2 0.5 -0.5 -0.1 -0.4 -0.4 -0.1 -0.7 -0.5 -0.2 0.0 -0.6 -0.6
Taking other prescription medications 1.2 1.9 3.4 -0.8 -1.3 -1.3 0.8 1.6 -1.6 -0.7 -1.7 -1.8 1.8 -1.3
Age when periods started (menarche) 0.7 1.8 3.6 -0.5 -1.3 -1.6 1.9 1.5 -1.7 0.1 -1.3 -1.4 1.6 -0.5
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 7.0 1.1 0.6 0.6 -2.6 -0.6 0.8 0.9 1.0 1.0 -0.8 1.2
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 6.2 0.4 2.4 1.1 0.4 -2.5 1.4 0.4 2.1 1.6 -2.5 0.1
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 2.3 0.2 0.2 1.5 -0.5 0.6 0.7 0.6 0.6 0.6 -0.3 0.4
Qualifications: CSEs or equivalent 0.3 0.5 1.6 1.2 0.2 0.6 -0.5 -0.8 0.9 -0.0 0.8 0.5 -0.5 0.5
Serious illness, injury or assault to yourself 0.2 0.2 1.3 0.0 -1.1 0.2 -0.2 0.4 -0.5 -0.2 -0.5 -0.4 0.5 -0.1
High blood pressure 1.0 2.8 7.0 2.4 1.6 0.8 0.1 2.0 1.2 2.6 1.6 1.2 -0.6 2.1
Hayfever, allergic rhinitis or eczema 0.7 1.5 7.3 0.8 1.2 0.1 2.7 1.2 0.2 1.2 0.7 0.7 -1.3 1.0
Multivitamins +/- minerals 1.6 2.0 7.5 -0.7 0.3 1.3 -2.2 -2.7 1.6 0.3 1.0 1.2 -1.1 0.9
Stomach or abdominal pain in last month 1.3 1.7 3.6 -1.3 -1.5 -0.9 0.6 -0.9 -1.9 -0.9 -1.6 -1.6 1.2 -1.1
Supplements: Glucosamine 0.9 1.2 2.8 -0.2 1.0 0.9 -0.9 -1.7 1.0 0.5 1.4 1.1 -1.5 0.9
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.2 1.1 0.8 0.2 -1.0 -0.5 0.3 -0.5 -0.1 0.3 -0.0 0.1
Medication: Atenolol 1.7 2.1 3.7 1.3 1.9 1.2 -0.5 0.8 1.5 1.6 1.8 1.6 -1.5 1.5
Medication: Levothyroxine sodium 3.9 6.6 11.1 -2.6 -2.6 -2.3 -0.6 -0.1 -3.3 -2.6 -3.2 -3.1 2.5 -3.0
Sitting height 0.3 1.9 14.1 -0.3 1.5 -1.8 0.3 -3.8 -0.5 0.8 -0.3 -0.4 -0.2 -0.1
Chronic bronchitis/emphysema (father) 0.5 0.6 3.1 -0.1 -0.3 -0.2 1.8 -0.9 -0.8 -0.6 -0.2 -0.8 0.4 -0.7
High blood pressure (mother) 0.9 1.3 7.2 0.3 -0.1 0.9 -1.3 2.7 0.3 1.5 0.2 -0.0 0.9 1.0
Body mass index (BMI) 1.1 4.6 10.8 2.0 1.1 2.1 -0.4 -0.7 2.6 1.9 3.3 2.3 -2.4 2.7
Impedance of leg (left) 0.3 1.3 11.0 0.5 0.0 1.2 -0.5 3.3 -0.3 1.1 -0.4 0.3 0.0 0.2
Leg predicted mass (left) 0.9 4.9 18.2 1.4 2.4 0.9 0.0 -4.3 2.0 1.1 2.5 2.2 -2.8 2.0
Trunk fat mass 2.5 10.7 18.8 2.7 3.2 3.4 -0.3 -1.8 3.6 2.9 4.2 3.9 -4.3 3.5
Waist circumference 2.7 9.7 18.3 3.4 2.6 2.9 0.3 -0.7 3.1 3.3 4.3 3.4 -3.8 3.9
Number of incorrect matches in round 0.8 1.3 4.0 -0.9 -0.9 -0.3 2.0 0.5 -0.9 -0.7 -1.2 -1.2 1.7 -1.0
Past tobacco smoking 1.2 2.1 5.3 2.1 0.6 0.8 -1.3 1.8 1.4 2.3 0.9 1.1 -0.1 2.0
Alcohol usually taken with meals 1.1 1.8 3.6 1.2 1.3 0.7 -1.0 -0.5 1.4 1.4 1.8 1.4 -1.9 1.3
Nervous feelings 1.8 3.4 12.2 2.4 1.3 0.8 1.5 3.5 1.2 2.2 1.5 1.5 -1.1 1.8
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 2.1 0.6 0.0 -0.2 -0.6 1.5 0.4 0.4 0.6 0.4 -0.4 0.4
Hearing difficulty/problems with background noise 0.4 0.6 2.3 -0.8 -1.1 0.3 1.1 1.5 -0.5 0.4 -0.2 -0.5 0.4 0.1
Hair/balding pattern: Pattern 2 1.5 2.0 5.3 2.3 1.4 -0.6 -0.7 0.6 0.9 1.2 1.9 1.2 -1.9 1.6
Had menopause 2.8 3.5 7.4 -1.9 -2.1 -1.4 -0.4 1.2 -2.0 -1.3 -2.4 -2.4 2.7 -1.6
Had other major operations 0.5 0.6 2.0 -0.2 -1.4 -1.3 0.0 -0.3 -0.9 -0.0 -0.3 -1.1 0.6 -0.0
Forced vital capacity (FVC) 0.5 2.1 4.7 -0.8 -1.6 -1.9 -1.6 0.5 -1.4 0.3 -1.8 -1.8 2.2 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.4 9.4 0.1 2.4 1.7 0.9 -2.8 1.3 0.0 2.6 1.7 -3.1 0.2
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 5.4 -0.3 0.6 1.0 -0.4 -2.3 0.0 0.1 0.2 0.3 -0.8 -0.2
Qualifications: None of the above 0.4 0.9 1.7 -1.0 -1.2 0.2 -1.1 1.3 -0.9 -0.4 -0.6 -1.1 1.2 -0.5
Financial difficulties in last 2 years 0.6 0.8 2.9 0.5 0.6 0.7 0.4 -0.4 0.9 1.7 1.0 0.7 -0.8 1.3
Mouth/teeth dental problems 0.4 0.7 4.1 -0.0 -0.3 -0.4 1.4 -2.0 0.0 -0.8 -0.1 -0.1 0.1 -0.4
Heart attack 1.7 2.2 3.5 -1.1 -1.0 -1.4 1.6 -0.8 -1.7 -1.9 -1.6 -1.7 1.4 -1.9
Allergy 1.6 3.6 5.0 -2.0 -2.1 -1.4 -0.9 -1.7 -1.6 -2.2 -2.1 -2.0 2.2 -2.2
Pain all over the body in last month 1.2 1.2 3.1 -1.0 -1.1 -1.1 -0.1 -0.1 -1.8 -0.5 -1.2 -1.5 1.2 -1.1
Diabetes (self-reported) 1.1 1.7 3.4 0.9 1.3 1.1 0.9 1.8 1.4 1.6 1.3 1.4 -1.1 1.1
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.5 0.3 0.3 -0.4 -0.0 0.7 -0.4 0.3 0.0 -0.2 -0.1 0.1
Medication: Ramipril 0.1 0.2 0.6 0.8 0.1 -0.4 -0.2 0.8 -0.5 0.1 0.2 -0.4 0.2 -0.0
Medication: Simvastatin 1.5 2.3 9.1 1.6 0.6 1.1 0.2 3.0 0.9 2.2 1.2 1.0 -0.6 1.7
Fluid intelligence score 0.3 0.6 2.1 0.3 0.0 -1.5 -0.2 0.7 -0.8 0.1 -0.9 -1.1 1.1 -0.7
Illnesses of siblings 0.7 1.0 5.5 -0.7 0.9 1.1 -0.3 -2.4 0.8 -0.6 0.5 0.9 -1.0 -0.3
Neuroticism score 0.1 0.3 1.4 0.8 0.7 -0.2 -0.6 1.2 0.0 0.2 0.3 0.0 -0.4 -0.2
Weight 1.3 6.5 11.4 2.1 2.3 1.9 -0.0 -2.9 2.6 2.2 3.4 2.8 -3.3 2.9
Impedance of arm (right) 0.2 0.8 3.6 -0.5 1.9 1.6 0.1 0.4 -0.1 -0.0 -0.5 0.5 -0.7 -1.0
Arm fat percentage (right) 1.8 7.2 12.8 2.0 2.4 3.5 -0.4 -0.5 3.2 2.3 3.6 3.2 -3.3 2.8
Trunk fat-free mass 0.3 1.8 13.0 0.3 1.1 -0.6 0.1 -3.6 0.5 0.2 1.1 0.6 -1.5 0.9
Hip circumference 1.8 8.0 14.7 2.6 2.6 2.7 -0.9 -2.0 2.8 2.5 3.8 3.0 -3.6 3.2
Time employed in main current job 1.0 1.2 2.9 1.1 0.4 0.9 -1.7 -0.7 1.2 0.5 1.0 1.3 -1.3 1.0
Alcohol intake versus 10 years previously 0.3 0.5 4.1 0.1 0.2 0.5 0.3 2.0 0.6 0.5 0.1 0.1 0.5 0.3
Father’s age at death 0.3 0.4 2.0 -0.7 0.2 0.3 1.4 -0.2 0.4 -1.0 0.2 -0.0 -0.6 -0.6
Worrier / anxious feelings 0.3 0.6 2.3 0.6 0.5 0.2 -0.3 1.2 0.6 1.5 0.8 0.6 -0.6 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.7 0.1 -0.0 -0.0 -0.8 0.7 -0.1 -0.1 -0.0 -0.3 0.3 -0.3
Falls in the last year 0.1 0.1 0.3 -0.3 -0.3 -0.4 -0.1 0.2 -0.4 -0.4 -0.3 -0.5 0.2 -0.6
Hair/balding pattern: Pattern 3 1.9 2.9 7.3 -2.1 -1.7 -0.1 1.5 -0.8 -0.8 -2.4 -1.6 -1.4 1.8 -2.7
Number of live births 0.7 1.0 2.3 1.4 0.7 0.3 -0.0 -1.0 0.6 1.1 1.2 1.0 -1.5 1.3
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 2.9 -0.7 -1.0 -1.7 -1.0 -0.1 -0.8 -0.0 -1.0 -1.1 1.3 -0.7
Pulse rate 0.7 1.3 3.3 1.8 1.5 0.7 -0.7 0.4 1.7 0.6 1.1 1.2 -0.5 1.0
Happiness 0.4 0.5 2.0 -1.2 0.4 1.1 1.4 0.5 -0.0 0.3 0.3 -0.4 0.7 -0.3
Noisy workplace 0.2 0.2 1.1 0.6 0.5 0.2 -1.1 0.1 0.2 -0.2 0.6 0.1 -0.2 0.2
Qualifications: A levels/AS levels or equivalent 1.9 4.2 9.2 2.3 1.6 0.4 1.9 0.5 1.6 3.0 1.8 2.4 -2.2 3.0
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.2 4.4 1.7 1.4 0.3 -0.4 0.2 0.9 2.0 1.7 1.6 -2.0 2.1
Mouth/teeth dental problems: Dentures 0.7 1.2 2.9 0.9 1.7 0.7 -0.4 1.1 1.3 0.6 1.3 1.2 -1.3 0.7
Asthma 2.0 4.0 6.8 2.1 1.4 2.0 -1.2 1.9 1.9 2.6 2.3 1.9 -1.8 2.5
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.5 6.2 -0.0 1.7 1.8 0.3 -0.9 1.8 1.1 2.4 1.8 -2.5 1.2
Medication: Cholesterol lowering 0.2 0.3 1.3 0.2 0.5 0.4 0.6 1.1 0.6 0.6 0.5 0.4 -0.2 0.2
Depression (self-reported) 0.2 0.2 0.7 -0.2 -0.3 -0.8 -0.7 -0.5 -0.6 -0.2 -0.1 -0.4 0.0 -0.3
Medication: Lansoprazole 1.1 1.3 5.1 0.4 -1.3 -0.3 -1.9 2.2 -0.1 0.7 -0.5 -0.7 1.5 0.3
Prospective memory result 0.4 0.5 1.4 -0.1 1.0 0.5 0.5 -0.3 0.9 -0.2 0.6 1.0 -1.2 -0.0
Lung cancer (father) 2.5 2.9 5.1 0.5 2.1 2.2 0.2 -0.8 2.3 1.5 2.2 2.0 -2.1 1.2
Illnesses of mother 0.8 1.0 6.2 -0.7 0.3 0.1 1.0 -2.5 -0.7 -1.3 -0.4 -0.0 -0.9 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 2.8 -1.3 -1.2 -1.7 -1.3 -0.8 -1.1 -0.2 -1.0 -1.4 1.3 -0.9
Pulse wave Arterial Stiffness index 0.6 0.7 2.0 -0.3 -0.2 -1.4 0.0 0.8 -1.3 -0.1 -0.9 -1.1 0.6 -0.9
Impedance of arm (left) 0.3 1.6 5.3 0.2 2.3 2.2 0.8 0.4 0.8 0.7 0.5 1.5 -1.6 -0.0
Arm fat mass (right) 1.6 6.7 12.5 2.2 2.3 2.5 -0.3 -1.5 2.9 2.3 3.5 2.9 -3.3 3.0
Trunk predicted mass 0.3 1.7 12.9 0.3 1.1 -0.6 0.1 -3.6 0.4 0.1 1.0 0.6 -1.4 0.9
Standing height 0.4 3.6 26.3 0.2 2.5 -0.7 0.8 -5.1 -0.0 0.6 0.4 0.9 -2.0 0.6
Length of working week for main job 0.9 1.0 2.5 1.0 -0.4 0.8 0.0 -0.7 1.2 0.8 1.6 1.0 -1.3 1.2
Exposure to tobacco smoke at home 1.0 1.1 2.0 -1.3 -1.1 -0.6 1.4 -0.8 -1.1 -1.3 -1.0 -1.1 0.6 -1.0
Breastfed as a baby 1.6 2.0 5.0 2.2 0.4 -0.3 -0.6 1.2 0.9 1.9 1.8 1.0 -1.2 2.2
Tense / ‘highly strung’ 0.4 0.6 2.8 0.4 0.7 0.1 1.7 1.1 0.4 0.8 0.7 0.4 -0.4 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.7 -0.5 0.2 -0.5 0.3 0.2 -0.9 -0.3 -0.3 -0.3 -0.3 -0.7
Hair/balding pattern: Pattern 4 0.9 2.1 6.9 -1.8 -1.0 0.6 -0.4 -2.6 0.5 -2.2 -0.8 -0.8 1.4 -1.8
Birth weight of first child 1.2 2.2 4.9 1.7 1.0 -0.2 1.8 -0.8 1.8 0.8 2.2 1.7 -1.7 1.3
Peak expiratory flow (PEF) 0.3 0.6 2.0 -1.4 -1.2 -0.8 0.4 -1.2 -0.0 -0.3 -0.1 -0.6 0.6 -0.6
Pulse wave reflection index 0.5 0.6 1.3 -0.8 -0.4 -1.0 1.1 1.2 -0.6 -0.0 -0.5 -0.6 0.4 -0.8
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.4 -0.6 0.3 0.3 -1.6 -1.0 -0.7 -1.2 -0.5 -0.4 -0.4 -1.1
Loud music exposure frequency 1.3 1.4 3.2 -1.2 -1.6 -0.6 -0.4 0.5 -0.6 -1.2 -1.4 -1.2 1.8 -1.4
Qualifications: O levels/GCSEs or equivalent 1.8 2.9 6.8 1.8 2.6 1.6 0.0 1.3 1.9 1.5 1.3 2.2 -1.8 1.5
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.1 -1.3 -1.4 -0.2 -0.4 1.5 -0.8 -0.0 -0.9 -0.9 0.9 -0.4
Blood clot in the leg (DVT) 0.2 0.3 1.0 -0.2 0.9 -0.0 0.7 -0.3 0.4 -0.3 0.7 0.5 -1.0 -0.2
Medication: Paracetamol 2.8 4.6 7.5 1.9 1.8 1.9 -1.1 0.6 2.4 2.6 2.6 2.4 -2.3 2.7
Headache pain in last month 5.1 8.7 16.0 2.9 2.3 2.7 -0.4 0.5 3.9 3.3 4.0 3.4 -3.0 3.4
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.5 -1.2 -0.3 0.8 -1.2 -1.6 -0.6 -1.1 -0.8 -0.3 0.1 -0.7
Glaucoma (self-reported) 1.8 2.2 4.2 -0.8 -1.4 -1.6 0.1 -0.5 -1.6 -1.6 -1.8 -1.9 2.1 -1.4
Gout (self-reported) 1.2 1.6 4.2 -0.6 -2.1 -1.1 2.0 -0.8 -0.4 -0.8 -1.3 -1.0 1.8 -0.6
Hypothyroidism/myxoedema (self-reported) 3.8 7.5 12.3 -3.0 -3.1 -1.9 0.1 -1.1 -3.5 -2.9 -3.5 -3.1 2.7 -3.0
Medication: Amlodipine 1.7 2.3 5.1 1.7 1.2 0.2 -0.1 1.4 1.8 2.3 1.9 1.4 -1.0 2.1
Medication: Ventolin 100micrograms inhaler 1.8 2.3 3.8 1.6 1.2 1.6 -2.0 0.5 1.7 1.5 1.6 1.5 -1.1 1.8
Birth weight 1.2 2.6 5.9 -0.3 1.8 1.0 -1.1 -2.4 1.7 0.9 1.7 1.9 -2.3 1.0
Chronic bronchitis/emphysema (mother) 1.1 1.3 6.3 -0.7 0.9 0.2 -2.0 -2.5 0.1 -0.9 0.4 0.1 -1.1 -0.8
High blood pressure (siblings) 0.9 1.4 8.1 0.9 -0.8 -0.8 -0.1 2.8 -0.1 1.3 0.0 -0.6 1.2 1.0
Forced vital capacity (FVC), Best measure 0.5 2.0 3.6 -1.1 -1.7 -1.9 -1.8 -0.3 -1.4 0.3 -1.5 -1.7 1.8 -0.7
Body fat percentage 2.9 11.6 19.5 2.9 2.9 4.1 -0.5 -0.3 3.9 3.2 4.4 4.1 -4.2 3.8
Leg fat percentage (right) 2.1 7.6 13.4 2.8 1.8 3.2 -0.7 0.9 2.9 2.9 3.7 3.0 -3.0 3.4
Arm fat-free mass (right) 0.6 3.3 12.6 1.3 1.3 0.2 -0.1 -3.5 1.6 1.1 2.0 1.7 -2.3 2.1
Exposure to tobacco smoke outside home 0.9 1.1 2.3 1.1 1.5 0.6 -1.1 -1.3 1.1 0.2 1.2 1.0 -1.4 0.3
Comparative body size at age 10 0.5 1.5 4.6 1.2 0.3 1.1 -2.1 -0.4 1.9 0.6 1.4 1.1 -0.8 1.1
Number of full brothers 0.3 0.4 2.0 -1.0 0.2 1.4 0.5 0.9 -0.1 0.2 0.2 0.1 -0.1 0.2
Worry too long after embarrassment 1.6 2.7 5.0 1.4 1.3 1.4 -0.5 0.4 1.5 2.2 2.2 1.8 -2.1 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 1.3 1.0 -0.1 -1.1 -0.1 0.9 -0.5 0.3 0.3 -0.3 -0.5 -0.1
Wheeze or whistling in the chest in last year 0.9 1.7 3.6 1.2 0.7 1.9 0.2 0.7 1.1 1.6 1.4 1.4 -1.4 1.6
Number of children fathered 0.4 0.4 1.5 0.3 -0.0 -0.1 0.8 -1.2 0.4 0.2 0.6 0.5 -0.9 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.1 -0.9 0.3 0.1 -0.6 -1.0 -0.5 -0.7 -0.9 -0.8 0.7 -1.0
Age at first live birth 1.0 1.8 4.1 1.1 1.6 1.0 0.8 -0.1 1.4 0.6 1.8 1.7 -2.0 1.2
Pulse wave peak to peak time 0.4 0.5 1.7 0.0 0.2 1.0 -0.2 -1.3 1.1 -0.3 0.6 0.8 -0.4 0.4
Health satisfaction 0.3 0.3 1.4 0.1 0.1 1.2 -0.1 1.2 0.6 0.4 0.4 0.2 0.3 0.4
Shortness of breath walking on level ground 1.0 1.2 2.7 1.3 1.4 1.6 -1.3 0.4 1.2 0.3 1.2 1.2 -0.9 0.6
Qualifications: College or University degree 0.2 0.5 3.1 -0.2 -0.2 -1.8 0.9 -0.6 -1.0 -0.0 -0.5 -0.4 -0.1 -0.0
Eye problems/disorders: None of the above 0.5 0.6 2.4 -0.2 1.2 0.0 0.1 -0.0 0.5 0.4 1.0 0.9 -1.6 0.4
Mouth/teeth dental problems: Loose teeth 0.7 0.9 2.2 -0.9 -0.4 -0.1 -1.3 -1.2 -1.5 -0.9 -0.4 -1.3 0.4 -0.5
Emphysema/chronic bronchitis 0.6 0.7 4.2 0.3 -0.6 -0.4 -2.0 1.4 -0.5 0.0 -0.1 -0.7 0.5 -0.0
Medication for pain relief, constipation, heartburn 0.4 0.8 2.0 -0.4 -0.6 -0.7 -0.5 0.4 -1.1 -0.9 -1.4 -0.7 0.9 -1.2
Neck or shoulder pain in last month 2.2 3.1 17.0 1.6 -1.1 0.0 -0.2 4.1 1.1 2.3 0.8 0.2 1.1 2.2
Medication: Blood pressure 1.0 1.7 3.2 1.7 1.2 -0.4 1.8 0.9 1.2 1.7 1.4 1.1 -0.8 1.4
Angina (self-reported) 0.9 1.1 3.3 -1.0 -1.6 -0.3 1.8 0.7 -1.0 -0.3 -0.7 -1.2 1.3 -0.7
Migraine (self-reported) 0.9 1.2 2.8 1.0 1.7 0.9 -0.8 0.9 1.4 1.1 1.1 1.2 -0.9 0.6
Medication: Ibuprofen 3.0 3.6 8.3 0.8 1.8 1.1 0.3 -0.6 2.0 2.1 2.9 2.1 -2.8 2.2
Medication: Allopurinol 0.7 1.0 2.9 -0.8 -1.7 -0.3 1.7 -0.4 -0.1 -1.2 -0.9 -0.6 1.1 -0.6
Medication: Omeprazole 4.2 5.1 9.6 -2.0 -2.6 -2.0 -0.5 -0.5 -3.1 -2.2 -2.6 -3.0 2.4 -2.1
Medication: Seretide 50 evohaler 1.2 1.4 2.6 1.2 1.3 0.9 -0.4 0.5 1.3 1.6 1.4 1.1 -1.3 1.4
Mean time to correctly identify matches 0.7 1.4 3.1 -1.5 -0.4 -0.6 1.1 -0.0 -1.0 -1.8 -1.4 -1.1 1.1 -1.6
Heart disease (mother) 1.1 1.4 2.7 -0.1 -1.5 -1.3 0.4 1.5 -1.4 -0.1 -1.2 -1.4 1.6 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.4 6.4 10.2 -2.9 -3.2 -2.5 0.2 -0.5 -3.0 -2.5 -2.9 -2.8 2.6 -2.5
Whole body fat mass 2.5 10.4 17.6 2.8 2.9 3.4 -0.7 -1.4 3.6 2.9 4.2 3.8 -4.1 3.7
Leg fat mass (right) 1.8 7.1 13.2 2.7 2.0 2.6 -0.6 -0.6 2.9 2.6 3.6 3.0 -3.2 3.4
Arm predicted mass (right) 0.5 2.6 10.2 1.3 1.0 0.2 0.0 -3.2 1.3 1.1 1.9 1.4 -1.9 2.0
Pulse rate, automated reading 0.1 0.4 1.4 0.1 0.7 0.4 -0.5 1.2 0.5 -0.7 -0.4 -0.2 1.0 -0.5
Alcohol intake frequency. 2.4 5.5 9.5 2.4 1.5 2.7 -0.2 2.5 3.1 2.6 2.8 2.5 -1.3 2.5
Comparative height size at age 10 0.3 1.8 13.8 -1.0 1.5 0.3 0.7 -3.7 -0.1 -0.5 -0.1 0.4 -1.2 -0.3
Number of full sisters 0.3 0.4 0.8 -0.3 -0.0 0.8 0.9 0.0 -0.9 -0.8 -0.6 -0.5 0.4 -0.7
Suffer from ‘nerves’ 0.7 1.1 3.1 0.4 -1.3 -1.8 0.8 1.7 -1.1 -0.2 -0.5 -1.0 0.8 -0.6
Overall health rating 0.1 0.2 1.4 0.4 -0.1 0.2 0.4 1.2 0.1 0.4 0.3 -0.3 0.1 0.0
Chest pain or discomfort 0.3 0.4 1.1 0.2 0.7 1.0 -0.0 0.9 0.6 1.1 0.7 0.4 -0.1 0.4
Had major operations 1.2 1.4 3.6 0.1 -1.5 -1.5 0.7 0.4 -1.9 -1.2 -1.3 -1.3 0.7 -1.2
Age at last live birth 2.5 3.6 7.0 1.0 1.8 1.7 1.4 -0.5 2.3 1.5 2.5 2.4 -2.7 1.9
Family relationship satisfaction 1.6 2.0 3.9 -2.0 -0.7 -1.1 1.9 -0.4 -1.5 -1.5 -1.3 -1.5 1.1 -1.7
Leg pain on walking 0.8 1.0 2.4 0.8 1.0 0.9 -1.4 1.5 0.3 0.9 0.9 0.7 -1.0 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.0 1.3 0.9 -0.1 -1.4 0.3 0.9 0.9 1.3 0.7 -0.9 0.9
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.8 -0.1 -0.6 0.6 -0.9 -0.7 0.2 -0.8 -0.1 -0.0 0.5 -0.3
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.5 -0.5 0.4 0.2 -0.5 -0.5 0.2 -0.7 -0.1 -0.2 0.4 -0.5
Medication: Aspirin 0.1 0.2 0.9 0.4 0.4 0.1 1.0 0.3 0.5 -0.2 -0.1 0.1 0.3 -0.2
Supplements: Vitamin C 0.4 0.4 1.6 -0.3 1.3 1.0 0.3 -0.1 0.3 0.4 0.3 0.8 -0.9 0.4
Knee pain experienced in last month 1.1 1.8 4.6 -2.1 -0.6 0.2 -0.7 -1.6 -1.6 -1.5 -1.5 -1.4 0.7 -1.4
Hypertension (Self-reported) 1.0 2.8 6.5 2.3 1.9 0.9 -0.2 1.8 1.4 2.5 1.6 1.3 -0.8 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.0 3.6 6.2 -2.1 -0.9 -1.6 -1.2 -2.0 -2.1 -2.1 -1.9 -2.3 1.5 -2.5
Illnesses of father: Heart disease 0.6 0.8 3.7 0.5 0.2 -0.2 1.9 0.7 0.8 1.2 0.5 0.9 -0.4 1.1
Illnesses of siblings: Diabetes 0.1 0.1 0.5 -0.2 -0.0 0.7 -0.1 -0.5 -0.6 0.3 -0.1 -0.1 -0.1 0.2
Smoking status: Previous 0.2 0.4 1.4 -0.5 0.3 0.0 1.2 -0.8 0.1 -0.6 0.3 0.2 -0.9 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 9.0 -0.2 0.6 -1.2 0.1 -3.0 -0.8 0.2 -0.5 -0.4 0.0 0.1
Whole body fat-free mass 0.5 2.9 15.4 0.8 1.6 0.1 0.1 -3.9 1.2 0.7 1.7 1.4 -2.1 1.5
Leg fat-free mass (right) 0.8 4.1 20.0 0.9 2.0 0.7 0.0 -4.5 1.8 0.7 2.0 1.9 -2.4 1.6
Arm fat percentage (left) 2.3 9.0 15.7 2.4 2.6 3.8 -0.1 -0.6 3.6 2.6 4.0 3.6 -3.7 3.2
Average weekly red wine intake 0.6 0.9 2.4 -1.1 0.4 0.5 0.5 -1.5 -0.5 -1.4 -0.5 -0.1 -0.8 -1.5
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.5 -0.4 0.4 -0.7 0.2 1.2 -0.7 -0.2 -1.0 -0.9 0.8 -1.2
Mood swings 0.3 0.6 2.1 0.1 -0.1 -1.1 -1.5 -0.4 -0.9 -0.7 -0.3 -1.0 0.0 -1.0
Loneliness, isolation 0.5 0.7 2.0 -1.2 -0.4 -0.2 0.3 0.5 -0.8 -1.4 -0.6 -0.9 0.7 -1.4
Long-standing illness, disability or infirmity 0.3 0.4 1.5 0.8 0.5 -1.2 0.6 1.2 -0.3 0.7 -0.1 -0.3 0.0 0.1
Ever had bowel cancer screening 0.3 0.4 1.5 0.3 0.1 1.2 0.2 -0.3 0.3 0.6 0.1 0.7 -0.7 0.9
Diabetes diagnosed by doctor 0.5 0.9 1.8 0.8 1.1 0.4 -0.0 0.9 1.0 1.3 0.9 1.2 -1.1 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 0.3 0.1 0.3 0.5 -0.1 0.5 0.8 0.5 0.4 -0.4 0.4
Friendships satisfaction 0.9 1.1 3.7 0.4 1.7 1.1 1.9 -0.9 0.3 0.3 0.8 0.7 -1.3 0.5
Qualifications: nursing, teaching 0.1 0.1 0.2 0.3 0.2 0.5 -0.4 -0.3 0.3 0.1 0.2 0.3 -0.4 0.3
Commuting to job workplace: Walk 1.5 1.6 7.8 1.2 0.8 -0.1 0.7 2.8 0.7 1.6 1.1 0.8 -0.7 1.3
Eye problems/disorders: Cataract 0.9 1.1 4.0 -0.6 -2.0 -0.8 0.6 -0.9 -0.8 -0.6 -1.1 -1.0 1.6 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.8 -1.1 -0.6 0.2 -1.1 1.3 -0.8 0.1 -0.8 -0.6 0.8 -0.3
Medication for cholesterol 2.5 3.8 9.5 -2.6 -1.4 -1.5 0.5 -2.5 -1.3 -3.1 -1.9 -1.5 0.8 -2.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 4.2 0.3 1.3 2.0 -1.4 0.1 1.4 0.6 1.3 1.0 -1.1 0.5
Back pain experienced in last month 0.6 0.8 4.2 -0.1 0.2 0.2 -2.0 1.8 0.4 0.7 0.8 0.0 -0.4 0.5
Mineral and other dietary supplements 0.4 0.6 2.5 0.5 0.3 -0.4 1.6 1.4 -0.9 0.0 -0.6 -0.3 0.2 -0.4
Breast cancer (self-reported) 1.0 1.2 2.6 -0.7 -1.3 -1.6 -1.1 0.2 -1.1 -1.1 -1.0 -1.1 1.2 -0.9
Asthma (self-reported) 1.8 3.6 6.3 2.0 1.4 1.7 -1.1 1.5 1.9 2.5 2.2 1.8 -1.7 2.4
Osteoporosis (self-reported) 0.6 0.7 1.8 0.9 -0.6 -1.1 -0.3 1.3 -1.1 0.7 -0.8 -0.7 0.7 0.5
Osteoarthritis (self-reported) 0.7 0.9 2.2 0.5 0.0 -0.1 -1.2 0.2 0.8 1.5 1.2 0.9 -1.0 1.3
Medication: Aspirin 0.2 0.2 1.0 0.5 0.3 0.3 1.0 0.4 0.7 0.2 0.0 0.3 0.3 0.1
Medication: Gliclazide 0.7 0.8 3.7 0.5 1.0 0.3 -1.9 -0.0 0.7 0.7 0.9 0.6 -0.9 0.7
Illnesses of father: None of the above (group 1) 1.2 1.5 4.8 0.3 1.0 1.6 -2.2 0.4 1.2 1.4 0.9 1.1 -0.8 1.2
Smoking status: Current 2.7 4.3 6.7 -2.4 -2.3 -1.3 -0.4 -0.4 -2.6 -2.2 -2.2 -2.6 2.3 -2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.4 4.8 -0.9 -2.2 -2.0 -1.2 1.2 -2.0 0.1 -1.1 -2.0 2.0 -0.5
Whole body water mass 0.5 3.1 16.3 0.8 1.6 0.1 0.1 -4.0 1.3 0.6 1.8 1.4 -2.1 1.5
Leg predicted mass (right) 0.8 4.1 19.9 1.0 1.9 0.7 0.2 -4.5 1.8 0.7 2.1 1.9 -2.4 1.6
Arm fat mass (left) 2.1 8.8 16.0 2.6 2.6 2.9 -0.2 -1.6 3.3 2.7 4.0 3.5 -3.8 3.4
Number of self-reported non-cancer illnesses 0.3 0.6 2.5 0.3 0.0 -0.8 -0.6 1.6 -0.7 1.1 -0.0 -0.6 0.5 0.5
Average weekly champagne plus white wine intake 2.9 4.0 11.7 1.5 1.6 0.9 -1.7 -0.8 2.2 1.4 2.7 2.4 -3.4 1.8
Miserableness 0.6 1.0 2.5 -0.4 -0.1 -1.4 -1.6 0.1 -1.0 -0.8 -0.9 -1.2 0.7 -1.3
Guilty feelings 0.3 0.4 1.1 0.2 0.7 0.8 0.3 -0.0 0.5 1.0 0.5 0.6 -1.0 0.4
Wears glasses or contact lenses 0.5 0.5 4.2 -0.7 0.0 0.8 2.1 0.6 0.2 0.2 -0.1 0.2 0.1 -0.1
Ever taken oral contraceptive pill 0.6 0.7 1.3 -0.6 -1.0 -1.1 0.7 0.0 -1.1 -0.6 -0.8 -0.9 0.8 -0.9
Hearing aid user 0.3 0.3 1.0 0.5 -0.5 -0.5 0.8 0.3 -0.3 1.0 0.2 -0.3 -0.0 0.8
Mother’s age at death 0.2 0.3 1.1 0.3 -0.2 0.5 -0.8 -0.5 0.5 -1.1 -0.0 0.1 0.3 -0.7
Financial situation satisfaction 1.8 2.3 5.1 1.1 2.3 1.8 0.8 0.8 2.0 0.9 1.8 1.8 -1.6 0.6
Tinnitus: Yes, now most or all of the time 1.9 2.3 3.5 1.3 1.2 1.1 1.2 1.5 1.8 1.9 1.6 1.8 -1.2 1.8
Commuting to job workplace: Public transport 1.0 1.2 3.5 -0.6 -0.5 -1.7 1.9 0.5 -1.3 -0.1 -1.2 -1.0 0.7 -0.9
Eye problems/disorders: Glaucoma 0.2 0.3 1.3 0.3 -0.3 0.1 0.2 0.8 -0.3 -0.2 -0.4 -0.7 1.1 -0.1
Medication: Blood pressure 1.9 3.6 6.8 1.7 2.1 2.6 -0.8 2.6 1.5 2.6 1.5 1.5 -0.6 2.2
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.9 0.3 -0.2 0.2 -1.0 0.5 -0.0 -0.1 0.1 -0.1 0.3 0.0
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.5 -0.1 0.2 0.5 -0.8 -0.5 1.2 0.6 1.1 0.9 -0.8 0.9
High cholesterol (Self-reported) 2.5 4.5 15.8 2.4 1.1 0.7 -0.6 4.0 1.5 3.5 1.7 1.4 -0.7 2.5
Medication: Bendroflumethiazide 4.3 6.5 11.0 3.3 3.1 2.0 -0.6 -0.4 2.7 2.8 2.8 2.9 -2.4 3.0
Medication: Paracetamol 3.8 5.8 10.1 2.4 2.4 1.7 -0.9 0.4 3.0 2.7 3.2 2.8 -2.5 2.9
Medication: Lisinopril 1.0 1.2 3.6 1.2 1.5 1.1 -0.2 0.8 1.9 1.0 1.1 1.2 -0.4 0.7
Medication: Atorvastatin 0.5 0.6 2.4 0.7 -0.8 -0.9 0.9 1.6 -0.3 0.4 -0.3 -0.5 0.9 0.2
Illnesses of father: High blood pressure 0.7 0.8 2.5 -0.1 -1.5 -0.9 -0.4 -0.1 -0.7 -0.7 -0.8 -1.1 1.6 -0.8
Alcohol drinker status: Never 0.5 0.5 1.3 0.2 0.7 1.0 -1.1 -0.3 0.7 0.6 0.8 0.8 -0.7 0.6
Ever smoked 1.3 2.3 5.9 -2.4 -0.7 -0.8 1.6 -1.0 -1.5 -2.3 -1.2 -1.2 0.5 -2.0
Basal metabolic rate 0.8 4.2 14.6 1.3 2.1 0.7 -0.0 -3.8 1.8 1.2 2.4 2.0 -2.7 2.0
Leg fat percentage (left) 1.8 6.6 11.6 2.4 1.5 3.3 -0.6 0.8 2.8 2.6 3.4 2.9 -2.8 3.2
Arm fat-free mass (left) 0.5 2.4 9.0 1.2 1.2 0.1 -0.6 -3.0 1.3 0.9 1.9 1.3 -1.9 1.8
Number of operations (self-reported) 0.1 0.2 0.7 -0.2 -0.8 0.1 -0.5 0.3 -0.7 0.1 -0.0 -0.7 0.3 -0.2
Average weekly beer plus cider intake 3.1 4.4 10.0 -1.8 -3.1 -1.6 0.8 1.6 -2.1 -1.5 -2.1 -2.5 3.2 -1.7
Irritability 0.2 0.3 0.9 -0.3 0.8 0.6 -0.8 -0.0 -0.0 -0.8 0.2 -0.2 -0.4 -0.9
Risk taking 0.6 0.9 4.1 -1.4 -0.4 0.7 0.2 -2.0 -0.5 -1.3 -0.2 -0.5 -0.3 -0.9
Ever had prostate specific antigen (PSA) test 1.8 2.1 3.1 0.8 1.4 1.0 -0.5 -1.7 1.4 1.5 1.5 1.8 -1.7 1.7
Fractured/broken bones in last 5 years 0.5 0.7 3.2 -0.7 0.0 0.7 -1.8 0.9 -0.6 -0.3 -0.9 -0.6 0.9 -0.7
Age started oral contraceptive pill 0.4 0.5 2.1 0.7 0.5 0.1 0.2 1.4 0.5 0.7 0.5 0.5 -0.2 1.0
Diastolic blood pressure, automated reading 1.3 3.9 12.3 -1.0 -1.8 -1.7 -0.7 1.2 -2.5 -0.7 -2.6 -2.6 3.5 -1.3
Ever depressed for a whole week 0.4 0.5 1.3 -1.1 0.0 0.9 -0.4 -0.9 -0.3 -0.7 -0.4 -0.3 -0.0 -1.0
Unable to work because of sickness or disability 0.2 0.2 0.7 0.5 -0.6 0.8 0.2 0.1 -0.3 0.5 -0.1 0.0 0.4 0.6
Commuting to job workplace: Cycle 1.2 1.5 9.9 0.0 0.1 1.1 3.1 -0.1 1.1 0.7 1.1 0.9 -0.9 0.8
Myopia 0.6 0.8 1.9 -0.5 0.9 1.3 0.6 0.7 1.4 1.1 1.1 0.8 -0.6 0.5
Vascular/heart problems diagnosed by doctor 0.6 1.7 4.4 -2.1 -1.2 -0.3 -0.4 -1.7 -0.9 -2.0 -1.2 -0.8 0.3 -1.5
Cholesterol lowering medication 3.8 5.6 22.0 3.0 0.6 1.2 -0.1 4.7 1.2 3.7 1.6 1.5 -0.6 2.9
Medication: Omeprazole (e.g. Zanprol) 2.6 3.1 6.7 -1.4 -2.0 -1.6 0.1 -0.5 -2.6 -2.0 -2.0 -2.4 1.7 -1.6
Pain experienced in last month 0.3 0.5 2.1 0.1 0.4 -0.4 1.5 -0.8 -0.6 -0.9 -0.6 -0.2 0.2 -0.7
Supplements: Calcium 0.3 0.4 0.9 -0.9 -0.2 -0.5 0.3 -0.6 -0.5 -0.6 -0.8 -0.6 0.6 -0.8
Basal cell carcinoma (self-reported) 2.6 3.1 5.5 2.3 1.3 1.3 0.4 0.6 2.0 2.0 2.0 2.1 -1.8 2.2
Heart attack/myocardial infarction (self-reported) 2.2 2.9 4.5 -1.4 -1.4 -1.4 1.6 -0.7 -2.0 -2.1 -1.8 -2.0 1.6 -2.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.8 0.0 0.8 -0.1 0.5 -0.2 0.3 -0.3 0.7 0.4 -0.9 -0.2
Heart disease (siblings) 0.3 0.3 1.8 0.5 0.7 -0.2 1.3 0.3 0.0 0.3 0.4 0.3 -0.8 0.3
Alcohol drinker status: Previous 0.9 1.1 3.0 0.8 0.7 1.3 -0.1 1.7 1.4 0.6 1.3 0.9 -0.7 0.6
Pack years of smoking 0.2 0.3 0.9 0.7 -0.8 0.5 -0.6 1.0 0.2 0.2 0.2 -0.3 0.7 0.5
Impedance of whole body 0.3 1.4 4.0 0.8 1.6 1.9 0.1 2.0 0.6 1.3 0.4 1.2 -1.1 0.4
Leg fat mass (left) 1.7 6.7 12.3 2.6 1.8 2.6 -0.5 -0.5 2.9 2.5 3.5 3.0 -3.1 3.3
Arm predicted mass (left) 0.6 3.0 9.3 1.1 1.5 0.6 -0.6 -3.0 1.5 1.1 2.0 1.6 -2.2 1.9