Hub : Genes

FBXW12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.064 0.0350 1.1e-03 0.018 0.023 0.001 0.026 0.003 0.0028 6.3e-04 0.21000 3.7e-04 0.11000
2 ROSMAP Brain Pre-frontal Cortex 0.050 0.0231 1.9e-05 0.010 0.033 0.028 0.031 0.022 0.0170 3.9e-05 0.00014 6.8e-05 0.00059

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.9 4.6 7.0 -2.6 -1.5
Bipolar Disorder or Schizophrenia 2.2 5.3 6.1 -2.5 -2.1
Depressed Affect (Nagel 2018) 3.0 6.2 9.3 -1.8 -3.1
Depression (Nagel 2018) 4.8 7.1 9.8 -3.1 -2.1
Intelligence (Savage-Jansen 2018) 0.5 1.7 2.9 -0.7 1.7
Neuroticism (Nagel 2018) 1.2 2.9 4.8 -1.0 -2.2
Schizophrenia (2018) 0.8 1.7 2.3 -1.0 -1.5
Schizophrenia vs Biploar Disorder 0.0 0.1 0.1 -0.3 -0.2
Worry (Nagel 2018) 0.8 1.7 2.2 -1.1 -1.5
Alzheimer’s Disease (in mother) 1.3 1.5 2.6 -1.6 -0.5
Alzheimer’s Disease (in father) 0.1 0.1 0.1 -0.4 0.4
Alzheimer’s Disease (including proxy) 0.6 0.9 1.6 -1.3 -0.5
Crohns Disease (2017) 1.1 2.5 4.7 0.4 2.2
Irritable Bowel Disease (IBD) 3.3 7.8 15.1 -0.7 3.9
Ulcerative Colitis (UC) 4.8 8.9 16.3 -1.3 4.0
Major Depression (MDD) 2.2 2.7 3.2 -1.5 -1.8
Reaction Time 0.4 0.8 1.6 0.1 -1.3
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.6 -0.8 0.2
Breast Cancer 0.1 0.3 0.5 0.2 0.7
Ovarian Cancer 0.6 0.8 1.5 0.2 -1.2
Prostate Cancer 3.0 4.2 7.7 -0.8 -2.8
Age at First Birth 0.3 0.4 0.7 -0.8 -0.2
Bipolar Disorder (2011) 0.2 0.2 0.3 -0.5 -0.5
Body Mass Index (BMI) (2010) 0.0 0.0 0.0 0.2 -0.2
Coronary Artery Disease (CAD) 3.1 3.7 5.5 -2.3 -1.4
Crohns Disease (2012) 0.1 0.2 0.3 -0.2 0.6
Mean Putamen Volume 1.2 1.3 2.2 0.7 1.5
Fasting Glucose 4.0 4.7 5.6 -2.0 -2.4
HbA1C 1.1 1.3 2.3 -0.4 1.5
HDL Cholesterol 0.9 1.4 2.8 1.7 0.1
LDL Cholesterol 0.7 1.1 2.2 -1.5 -0.2
Lupus 0.1 0.1 0.3 -0.5 0.2
Neuroticism (2016) 1.8 2.6 4.6 -0.8 -2.1
Primary Biliary Cirrhosis 1.0 1.4 2.1 0.9 1.4
Rheumatoid Arthritis 0.3 0.5 0.8 0.9 0.4
Schizophrenia (2014) 0.8 1.7 2.6 -0.9 -1.6
Triglycerides 1.0 1.6 2.9 0.5 1.7
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.1 -1.0 -0.7
Ulcerative Colitis 3.2 4.7 6.8 -1.6 2.6
Blood Eosinophil Count 1.3 9.7 11.6 -2.8 3.4
Blood Platelet Count 0.6 7.2 12.2 1.5 3.5
Blood Red Count 1.0 10.1 18.8 -4.3 -1.2
Blood White Count 0.8 6.0 10.7 -1.2 -3.3
Heel T-Score 0.6 5.0 9.1 -3.0 1.0
BMI 0.5 2.8 2.8 -1.7 -1.7
Height 0.5 9.5 16.5 -1.6 4.1
Waist Hip Ratio (WHR) 5.3 23.6 41.3 2.4 6.4
Systolic Blood Pressure 2.1 10.6 10.8 -3.3 -3.2
Smoking Status 0.5 1.1 1.5 0.9 -1.2
Allergy or Eczema 0.1 0.2 0.3 0.5 -0.4
Cardiovascular Disease 1.9 6.4 7.8 -2.8 -2.2
Hypothyroidism (self reported) 4.0 9.2 12.5 -2.4 -3.5
Respiratory disease 0.4 0.8 1.6 0.3 1.3
Type 2 Diabetes (T2D) (2018) 1.2 2.2 3.8 -2.0 0.7
Lung FEV1/FVC ratio 0.7 3.7 6.7 -0.8 2.6
Lung FVC 0.7 3.8 5.9 1.3 2.4
Neuroticism 1.4 3.4 6.0 -0.9 -2.5
Chronotype (morning person) 1.5 3.6 6.7 -2.6 -0.7
Hair Pigment 0.3 7.7 12.8 3.6 1.6
Tanning 0.0 0.1 0.1 0.4 -0.2
Hand grip strength (left) 1.8 4.6 6.4 -2.5 -1.7
Number of treatments/medications taken 1.5 2.8 3.9 -1.3 -2.0
Average weekly spirits intake 0.8 1.0 1.9 1.4 -0.1
Sensitivity / hurt feelings 1.5 2.6 4.0 1.1 2.0
Frequency of depressed mood in last 2 weeks 3.8 5.3 5.8 -2.2 -2.4
Hearing difficulty/problems: Yes 0.7 1.1 1.9 0.5 1.4
Relative age of first facial hair 0.3 0.6 0.7 0.8 -0.7
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.1 -1.1 -0.8
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.4 0.6 0.6
Ever had hysterectomy (womb removed) 0.1 0.1 0.1 0.2 -0.4
Systolic blood pressure, automated reading 1.7 4.9 7.0 -1.7 -2.7
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.5 -0.0
Angina 0.2 0.2 0.4 -0.7 -0.0
Medication for hormone replacement therapy 0.3 0.4 0.6 -0.4 -0.8
Vitamin and mineral supplements 0.6 0.8 1.5 -1.2 -0.2
Supplements: Zinc 0.0 0.0 0.0 -0.1 -0.1
Medication: Co-codamol 0.6 0.7 1.0 0.6 -1.0
Medication: Metformin 0.6 0.8 1.4 -0.5 1.2
Diabetes (father) 0.7 0.9 1.8 0.1 1.4
Diabetes (mother) 1.4 1.7 2.9 -1.7 -0.7
Severe depression (siblings) 0.5 0.5 0.9 -0.3 -1.0
Pack years adult smoking proportion 5.7 8.8 15.0 -1.6 -3.9
Impedance of leg (right) 0.5 2.4 2.9 1.7 1.4
Leg fat-free mass (left) 0.6 3.4 5.8 -2.4 -1.0
Trunk fat percentage 0.3 1.2 2.1 -1.4 -0.5
Hand grip strength (right) 1.9 5.2 7.8 -2.8 -1.6
Townsend deprivation index at recruitment 0.3 0.4 0.9 0.1 -0.9
Current tobacco smoking 1.0 1.6 2.1 1.0 -1.4
Average weekly fortified wine intake 0.0 0.0 0.1 -0.1 -0.3
Maternal smoking around birth 1.4 2.0 3.0 1.7 1.0
Fed-up feelings 2.6 4.8 8.0 -1.2 -2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 4.2 -2.0 -1.2
Relative age voice broke 0.7 1.0 1.9 0.4 -1.4
Taking other prescription medications 3.2 5.0 6.4 -1.9 -2.5
Age when periods started (menarche) 2.6 6.3 10.8 -1.4 -3.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 0.2 0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 6.2 -2.5 0.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 0.8 -0.5 -0.9
Qualifications: CSEs or equivalent 2.0 2.7 3.0 -1.5 -1.7
Serious illness, injury or assault to yourself 4.1 4.9 7.0 -2.6 -1.7
High blood pressure 1.9 5.2 6.2 -2.5 -2.0
Hayfever, allergic rhinitis or eczema 0.5 1.0 2.0 0.0 -1.4
Multivitamins +/- minerals 0.0 0.1 0.1 0.3 -0.1
Stomach or abdominal pain in last month 0.5 0.7 1.1 0.5 -1.1
Supplements: Glucosamine 1.2 1.6 3.1 1.7 0.3
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 3.1 0.4 -1.7
Medication: Atenolol 0.8 1.0 1.4 -0.7 -1.2
Medication: Levothyroxine sodium 1.6 2.7 3.8 -1.3 -1.9
Sitting height 0.4 3.1 6.3 -2.5 0.1
Chronic bronchitis/emphysema (father) 0.2 0.2 0.5 0.7 -0.1
High blood pressure (mother) 0.5 0.7 1.3 -1.1 0.3
Body mass index (BMI) 0.4 1.6 1.7 -1.2 -1.3
Impedance of leg (left) 0.5 2.4 3.1 1.3 1.8
Leg predicted mass (left) 0.6 3.2 5.5 -2.4 -0.9
Trunk fat mass 0.4 1.9 3.4 -1.9 -0.6
Waist circumference 0.3 1.0 1.9 -0.4 1.4
Number of incorrect matches in round 3.9 6.5 12.8 -0.3 -3.6
Past tobacco smoking 0.7 1.2 1.7 -1.3 -0.9
Alcohol usually taken with meals 0.2 0.3 0.6 -0.7 0.1
Nervous feelings 0.6 1.1 2.1 -1.5 -0.2
Frequency of tenseness / restlessness in last 2 weeks 4.2 6.6 11.1 -1.4 -3.3
Hearing difficulty/problems with background noise 0.4 0.7 0.7 0.8 0.9
Hair/balding pattern: Pattern 2 1.7 2.2 2.2 1.5 1.5
Had menopause 1.5 1.9 2.5 1.2 1.6
Had other major operations 1.3 1.5 3.0 1.7 -0.3
Forced vital capacity (FVC) 0.5 1.9 3.8 -0.3 1.9
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 4.4 -2.1 0.8
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.5 -0.4 -1.2
Qualifications: None of the above 0.6 1.2 2.4 1.6 -0.1
Financial difficulties in last 2 years 0.4 0.6 1.0 1.0 0.3
Mouth/teeth dental problems 2.1 3.2 3.4 -1.7 -1.8
Heart attack 2.0 2.6 3.6 -1.9 -1.3
Allergy 0.0 0.0 0.1 -0.3 0.0
Pain all over the body in last month 5.1 5.5 8.9 -1.5 -3.0
Diabetes (self-reported) 1.5 2.3 3.8 -0.9 2.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.9 -0.1 -0.9
Medication: Ramipril 0.1 0.1 0.1 0.3 -0.3
Medication: Simvastatin 0.8 1.2 2.3 -1.5 0.3
Fluid intelligence score 1.0 2.1 2.4 -1.6 -1.3
Illnesses of siblings 1.3 1.9 2.0 1.3 1.4
Neuroticism score 0.4 0.9 1.7 -0.2 -1.3
Weight 0.5 2.5 4.6 -2.1 -0.6
Impedance of arm (right) 0.3 1.5 3.0 0.2 1.7
Arm fat percentage (right) 0.5 2.1 2.6 -1.6 -1.3
Trunk fat-free mass 0.4 2.1 3.8 -1.9 -0.6
Hip circumference 0.3 1.5 1.9 -1.1 -1.4
Time employed in main current job 0.7 0.8 1.3 -1.1 -0.6
Alcohol intake versus 10 years previously 1.0 1.5 2.9 -1.7 -0.3
Father’s age at death 2.1 2.9 5.7 -0.2 2.4
Worrier / anxious feelings 2.5 4.8 5.1 -2.1 -2.2
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.5 4.7 0.6 -2.2
Falls in the last year 3.8 5.1 5.2 2.3 2.2
Hair/balding pattern: Pattern 3 0.3 0.4 0.4 -0.6 -0.6
Number of live births 0.6 0.8 1.3 0.6 1.1
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 9.2 -0.1 3.0
Pulse rate 1.4 2.3 4.0 -0.8 2.0
Happiness 0.7 0.8 1.3 -0.6 -1.1
Noisy workplace 0.2 0.3 0.5 0.7 -0.3
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.1 -0.4 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.7 0.1 -1.3
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 0.5 -0.2
Asthma 0.2 0.4 0.7 0.1 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.4 0.1
Medication: Cholesterol lowering 1.4 2.2 4.4 -2.1 -0.2
Depression (self-reported) 0.3 0.3 0.3 0.5 -0.6
Medication: Lansoprazole 1.2 1.4 1.6 -1.3 -1.0
Prospective memory result 0.2 0.3 0.6 0.7 -0.0
Lung cancer (father) 2.3 2.7 4.1 -1.1 -2.0
Illnesses of mother 0.2 0.2 0.3 0.6 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 7.9 -0.0 2.8
Pulse wave Arterial Stiffness index 0.0 0.0 0.0 0.2 0.0
Impedance of arm (left) 0.4 2.0 4.0 0.0 2.0
Arm fat mass (right) 0.5 2.0 2.8 -1.7 -1.1
Trunk predicted mass 0.4 2.2 4.1 -2.0 -0.6
Standing height 0.4 3.8 4.6 -2.1 1.7
Length of working week for main job 1.3 1.5 1.5 1.2 1.2
Exposure to tobacco smoke at home 5.0 5.6 5.6 -2.4 -2.4
Breastfed as a baby 0.0 0.1 0.1 0.3 0.1
Tense / ‘highly strung’ 2.2 3.6 7.2 -0.1 -2.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.0 0.8 -1.0
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 0.4 -0.3
Birth weight of first child 2.7 5.0 6.4 1.9 2.5
Peak expiratory flow (PEF) 0.6 1.4 2.2 -1.5 0.7
Pulse wave reflection index 0.1 0.1 0.2 0.5 -0.0
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.8 -0.1 -1.3
Loud music exposure frequency 0.4 0.5 0.9 0.0 1.0
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.7 -1.7 -0.2
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 1.4 1.2 1.2
Blood clot in the leg (DVT) 0.4 0.5 0.6 -0.5 0.8
Medication: Paracetamol 0.9 1.5 1.7 1.2 -1.3
Headache pain in last month 1.1 1.9 2.7 1.6 1.1
Medication for cholesterol, blood pressure or diabetes 2.0 3.3 5.9 2.4 0.8
Glaucoma (self-reported) 1.1 1.3 2.5 -1.6 -0.2
Gout (self-reported) 0.4 0.6 1.2 -1.1 0.0
Hypothyroidism/myxoedema (self-reported) 1.9 3.7 5.3 -1.5 -2.3
Medication: Amlodipine 0.1 0.2 0.4 0.0 0.6
Medication: Ventolin 100micrograms inhaler 0.6 0.7 1.5 -1.2 -0.0
Birth weight 0.1 0.1 0.2 -0.5 0.1
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.5 0.7 0.5
High blood pressure (siblings) 0.5 0.7 0.7 -0.8 -0.8
Forced vital capacity (FVC), Best measure 0.7 2.4 4.8 0.1 2.2
Body fat percentage 0.3 1.3 1.9 -1.4 -0.9
Leg fat percentage (right) 0.3 0.9 1.6 -0.5 -1.2
Arm fat-free mass (right) 0.4 2.0 3.3 -1.8 -0.7
Exposure to tobacco smoke outside home 1.0 1.4 2.2 -0.8 -1.5
Comparative body size at age 10 0.6 1.7 1.8 1.2 1.4
Number of full brothers 1.4 1.7 2.8 1.7 -0.8
Worry too long after embarrassment 2.2 3.6 5.1 1.5 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.6 -0.0 -1.3
Wheeze or whistling in the chest in last year 0.4 0.6 0.9 0.9 0.6
Number of children fathered 0.3 0.3 0.6 -0.0 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 1.7 -1.3 -0.2
Age at first live birth 0.7 1.3 2.6 -1.6 -0.1
Pulse wave peak to peak time 0.1 0.2 0.3 -0.6 -0.1
Health satisfaction 0.9 1.2 1.6 -0.9 -1.3
Shortness of breath walking on level ground 1.0 1.2 1.4 1.0 1.2
Qualifications: College or University degree 1.2 3.7 7.4 -2.7 0.2
Eye problems/disorders: None of the above 0.6 0.7 1.2 1.1 -0.4
Mouth/teeth dental problems: Loose teeth 4.5 5.4 6.6 2.0 2.6
Emphysema/chronic bronchitis 4.8 5.4 7.9 2.8 1.7
Medication for pain relief, constipation, heartburn 0.0 0.1 0.1 -0.2 0.3
Neck or shoulder pain in last month 0.5 0.7 1.4 1.2 0.2
Medication: Blood pressure 2.2 3.9 4.9 -2.2 -1.7
Angina (self-reported) 0.1 0.2 0.3 -0.6 -0.0
Migraine (self-reported) 3.3 4.0 7.3 0.9 2.7
Medication: Ibuprofen 0.0 0.0 0.1 0.1 -0.2
Medication: Allopurinol 1.2 1.6 3.1 -1.8 -0.2
Medication: Omeprazole 1.0 1.2 2.0 1.4 0.5
Medication: Seretide 50 evohaler 1.5 1.7 2.9 -1.7 -0.7
Mean time to correctly identify matches 0.4 0.7 1.4 -0.0 -1.2
Heart disease (mother) 0.1 0.2 0.3 0.6 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.6 3.1 4.5 1.3 2.1
Whole body fat mass 0.5 2.0 3.2 -1.8 -0.9
Leg fat mass (right) 0.3 1.3 1.6 -1.3 -1.0
Arm predicted mass (right) 0.5 2.3 3.9 -2.0 -0.9
Pulse rate, automated reading 0.9 3.0 4.0 -1.4 2.0
Alcohol intake frequency. 0.6 1.4 2.7 -1.7 0.0
Comparative height size at age 10 0.2 1.1 2.1 0.4 1.4
Number of full sisters 1.5 1.8 2.5 1.6 1.1
Suffer from ‘nerves’ 0.2 0.3 0.6 -0.2 -0.8
Overall health rating 0.3 0.7 1.2 -0.6 -1.1
Chest pain or discomfort 1.2 1.7 2.3 1.5 -1.1
Had major operations 4.5 5.3 5.5 -2.3 -2.2
Age at last live birth 0.5 0.7 1.5 -1.2 -0.1
Family relationship satisfaction 1.8 2.3 3.9 -0.8 -2.0
Leg pain on walking 1.0 1.3 2.3 1.5 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.1 -1.4 0.4
Commuting to job workplace: Car/motor vehicle 6.9 7.9 10.7 3.3 2.3
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 2.1 1.4 0.8
Medication: Aspirin 0.3 0.4 0.8 -0.9 0.2
Supplements: Vitamin C 1.9 2.3 3.3 1.8 1.1
Knee pain experienced in last month 5.2 8.0 10.6 3.3 2.3
Hypertension (Self-reported) 1.7 4.6 5.9 -2.4 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 1.7 0.8 1.3
Illnesses of father: Heart disease 0.3 0.4 0.8 0.9 -0.1
Illnesses of siblings: Diabetes 1.3 1.6 2.2 -1.0 -1.5
Smoking status: Previous 0.7 1.1 1.7 0.7 1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.3 -0.6 0.0
Whole body fat-free mass 0.5 2.9 5.2 -2.3 -0.7
Leg fat-free mass (right) 0.7 3.5 6.5 -2.6 -0.7
Arm fat percentage (left) 0.5 2.0 2.7 -1.7 -1.2
Average weekly red wine intake 0.1 0.1 0.1 -0.1 -0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.9 -1.0 -0.2
Mood swings 2.7 4.9 5.3 -2.1 -2.3
Loneliness, isolation 3.0 4.2 5.2 -1.8 -2.3
Long-standing illness, disability or infirmity 0.6 1.0 1.0 -1.0 1.0
Ever had bowel cancer screening 0.1 0.2 0.3 0.5 -0.1
Diabetes diagnosed by doctor 1.7 2.7 2.8 -1.7 1.6
Ever had stillbirth, spontaneous miscarriage or termination 3.3 3.5 5.0 2.2 1.4
Friendships satisfaction 2.7 3.4 4.0 -1.7 -2.0
Qualifications: nursing, teaching 0.8 1.2 2.0 -0.7 -1.4
Commuting to job workplace: Walk 4.6 5.0 6.8 -2.6 -1.8
Eye problems/disorders: Cataract 0.4 0.5 0.9 -1.0 0.2
Mouth/teeth dental problems: Mouth ulcers 5.1 8.1 10.4 2.4 3.2
Medication for cholesterol 0.4 0.7 1.2 1.1 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 -0.1 -0.4
Back pain experienced in last month 1.6 2.4 3.3 1.8 1.2
Mineral and other dietary supplements 0.5 0.6 1.1 -1.1 -0.4
Breast cancer (self-reported) 0.1 0.1 0.2 -0.5 0.2
Asthma (self-reported) 0.3 0.6 1.0 0.5 1.0
Osteoporosis (self-reported) 4.3 5.4 10.1 -0.8 -3.2
Osteoarthritis (self-reported) 0.3 0.4 0.7 0.9 -0.3
Medication: Aspirin 0.7 0.9 1.8 -1.3 0.2
Medication: Gliclazide 0.0 0.0 0.1 -0.3 -0.1
Illnesses of father: None of the above (group 1) 0.3 0.3 0.6 0.3 0.8
Smoking status: Current 0.8 1.2 2.0 0.6 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.8 -0.4 1.4
Whole body water mass 0.5 2.7 4.9 -2.2 -0.7
Leg predicted mass (right) 0.6 3.4 6.3 -2.5 -0.6
Arm fat mass (left) 0.4 1.7 2.6 -1.6 -0.9
Number of self-reported non-cancer illnesses 1.9 3.4 3.6 -1.8 -1.9
Average weekly champagne plus white wine intake 0.0 0.0 0.0 -0.2 0.1
Miserableness 2.8 4.8 8.6 -1.0 -2.9
Guilty feelings 0.1 0.2 0.3 0.6 0.1
Wears glasses or contact lenses 3.5 4.1 7.3 -2.7 -0.9
Ever taken oral contraceptive pill 0.8 0.8 1.5 0.5 -1.2
Hearing aid user 1.0 1.1 1.8 -1.3 0.7
Mother’s age at death 0.4 0.6 1.1 0.2 1.0
Financial situation satisfaction 0.6 0.7 1.5 -0.0 -1.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 0.7 -0.8 0.8
Commuting to job workplace: Public transport 4.2 5.0 6.1 -2.5 -2.0
Eye problems/disorders: Glaucoma 0.4 0.5 0.9 -1.0 -0.0
Medication: Blood pressure 0.8 1.5 2.9 -1.7 -0.3
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.6 0.7 0.3
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.2 -0.1 0.5
High cholesterol (Self-reported) 0.5 0.9 1.5 -1.2 0.6
Medication: Bendroflumethiazide 0.3 0.4 0.5 -0.7 -0.5
Medication: Paracetamol 1.7 2.7 5.3 0.4 -2.3
Medication: Lisinopril 2.2 2.8 4.0 -2.0 -1.3
Medication: Atorvastatin 0.1 0.1 0.2 0.1 0.5
Illnesses of father: High blood pressure 1.2 1.5 2.9 -1.7 0.4
Alcohol drinker status: Never 1.2 1.4 1.5 1.2 1.2
Ever smoked 0.4 0.6 1.3 1.1 0.1
Basal metabolic rate 0.5 2.9 5.3 -2.3 -0.8
Leg fat percentage (left) 0.2 0.9 1.1 -0.8 -1.1
Arm fat-free mass (left) 0.6 3.0 4.6 -2.1 -1.2
Number of operations (self-reported) 0.6 0.9 1.8 0.2 -1.3
Average weekly beer plus cider intake 0.2 0.3 0.6 -0.2 -0.8
Irritability 1.8 3.0 5.8 -0.4 -2.4
Risk taking 1.7 2.4 3.1 1.8 1.3
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.3 -0.1 1.5
Fractured/broken bones in last 5 years 0.3 0.3 0.4 -0.5 -0.6
Age started oral contraceptive pill 0.1 0.2 0.2 -0.3 0.5
Diastolic blood pressure, automated reading 2.7 8.4 9.8 -2.6 -3.1
Ever depressed for a whole week 0.6 0.8 0.9 0.8 -1.0
Unable to work because of sickness or disability 0.2 0.3 0.5 0.7 0.2
Commuting to job workplace: Cycle 0.5 0.6 1.2 -1.1 -0.0
Myopia 4.6 6.6 8.7 -2.9 -2.1
Vascular/heart problems diagnosed by doctor 3.4 9.4 11.8 3.4 2.6
Cholesterol lowering medication 0.1 0.1 0.2 -0.1 0.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.5 0.7 0.4
Pain experienced in last month 0.5 0.8 1.6 -1.2 -0.0
Supplements: Calcium 0.5 0.5 0.9 1.0 0.3
Basal cell carcinoma (self-reported) 0.3 0.4 0.8 -0.9 -0.2
Heart attack/myocardial infarction (self-reported) 1.9 2.5 3.3 -1.8 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.0 -1.0 0.3
Heart disease (siblings) 0.8 1.0 1.1 -0.9 -1.1
Alcohol drinker status: Previous 0.2 0.3 0.5 0.7 0.0
Pack years of smoking 4.5 6.6 10.8 -1.6 -3.3
Impedance of whole body 0.5 2.7 4.8 0.7 2.2
Leg fat mass (left) 0.4 1.7 2.3 -1.5 -1.0
Arm predicted mass (left) 0.3 1.7 2.8 -1.7 -0.7