TWAS hub - FCN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1962	0.0542	4.1e-04	-0.002	NA	0.006	NA	0.018	4.9e-01	NA	1.1e-01	NA	1.4e-02
2	GTEx	Whole Blood	0.1340	0.0400	8.9e-04	0.123	NA	0.121	NA	0.125	1.9e-11	NA	3.1e-11	NA	1.4e-11
3	METSIM	Adipose	0.1116	0.0278	8.8e-07	0.058	0.050	0.045	0.048	0.053	4.4e-09	4.5e-08	2.3e-07	9.1e-08	2.0e-08
4	NTR	Blood	0.1350	0.0191	0.0e+00	0.082	0.076	0.085	0.094	0.091	4.4e-25	1.9e-23	6.0e-26	1.4e-28	1.1e-27
5	YFS	Blood	0.3441	0.0272	0.0e+00	0.254	0.284	0.327	0.334	0.323	1.6e-82	8.9e-94	1.2e-110	9.9e-114	2.7e-109
6	TCGA	Breast Invasive Carcinoma	0.0722	0.0297	1.3e-07	0.042	0.045	0.033	NA	0.046	5.0e-09	1.4e-09	2.4e-07	NA	8.5e-10
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0599	0.0283	6.3e-04	0.023	0.014	0.020	NA	0.019	1.2e-03	8.0e-03	2.4e-03	NA	2.6e-03
8	TCGA	Lung Adenocarcinoma	0.0358	0.0155	5.6e-04	0.034	0.027	0.024	NA	0.030	6.0e-05	3.1e-04	7.6e-04	NA	1.6e-04
9	TCGA	Lung Squamous Cell Carcinoma	0.1027	0.0404	1.9e-04	0.035	0.039	0.024	NA	0.024	6.4e-05	2.8e-05	7.9e-04	NA	8.5e-04
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.2240	0.0850	2.9e-04	0.020	0.038	0.017	NA	0.016	1.6e-02	1.3e-03	2.3e-02	NA	2.6e-02
11	TCGA	Skin Cutaneous Melanoma	0.1810	0.0770	1.5e-03	0.139	0.123	0.133	NA	0.153	1.5e-04	3.6e-04	2.1e-04	NA	6.8e-05
12	TCGA	Stomach Adenocarcinoma	0.0480	0.0220	1.4e-03	0.054	0.034	0.027	NA	0.030	8.7e-05	1.7e-03	4.8e-03	NA	2.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Exposure to tobacco smoke outside home	4.7	6.3	10.0	-1.6	-1.3	-2.9	-2.9	-3.2	-2.5	-3.2	-1.7	-2.8	-2.1	-2.7	-2.5
Loud music exposure frequency	4.2	4.6	8.7	-2.8	-1.5	-2.3	-2.2	-2.4	-2.2	-2.9	-0.4	-1.7	0.0	-1.9	-2.9
Unable to work because of sickness or disability	4.1	5.4	9.5	-1.9	-0.1	-3.0	-2.4	-2.7	-2.0	-2.5	-2.1	-3.1	-1.4	-2.6	-2.4
Glaucoma (self-reported)	4.0	4.6	8.4	2.6	1.3	2.4	2.2	2.9	1.8	2.6	1.3	2.3	1.5	2.3	1.9
Financial situation satisfaction	3.8	4.8	8.5	-1.7	0.1	-1.9	-1.9	-2.6	-2.2	-2.6	-2.8	-1.8	-1.3	-2.8	-2.9
Long-standing illness, disability or infirmity	3.2	4.9	11.4	-1.8	-0.1	-1.3	-1.3	-2.5	-1.7	-2.4	-3.4	-2.2	-2.5	-2.7	-2.5
Falls in the last year	3.1	4.1	12.2	-3.5	-0.3	-2.0	-1.8	-1.8	-1.6	-2.6	-2.0	-1.3	-0.9	-2.1	-2.6
Ulcerative Colitis (UC)	2.7	5.1	10.3	1.9	1.2	1.9	2.8	2.8	2.3	1.7	1.5	2.7	3.2	2.4	1.8
Wheeze or whistling in the chest in last year	2.7	4.8	8.8	-2.9	-0.7	-1.9	-2.0	-2.6	-1.7	-2.4	-1.3	-3.0	-1.8	-2.3	-2.5
Irritability	2.7	4.6	7.7	-0.4	-0.3	-1.7	-2.5	-2.8	-2.1	-2.7	-2.2	-1.6	-2.3	-2.8	-2.4
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	7.9	0.5	2.4	-1.7	-0.1	-0.7	-1.6	-1.2	-2.8	-1.5	-1.2	-2.1	-1.5
Leg pain on walking	2.4	3.1	9.6	-2.2	0.4	-2.0	-0.7	-1.5	-1.7	-1.5	-1.2	-3.1	-1.8	-1.8	-1.6
Illnesses of father: None of the above (group 1)	2.4	3.0	5.6	-2.4	0.2	-1.8	-2.3	-1.5	-2.2	-1.3	-1.2	-1.7	-1.5	-1.9	-1.7
Ulcerative Colitis	2.3	3.4	11.7	1.0	0.3	1.1	1.8	2.0	1.7	1.4	1.7	2.1	3.4	2.1	1.7
Maternal smoking around birth	2.3	3.3	8.1	-1.5	0.3	-2.0	-1.7	-1.7	-2.1	-1.8	-1.3	-2.8	-1.9	-2.1	-1.5
Hearing difficulty/problems with background noise	2.2	3.4	6.7	-1.9	-0.2	-1.8	-1.1	-1.9	-2.2	-2.0	-1.8	-2.6	-1.1	-2.1	-2.2
Eye problems/disorders: Glaucoma	2.2	2.6	4.5	1.6	0.8	2.1	2.0	2.1	1.6	2.1	0.4	1.4	0.6	1.7	1.7
Health satisfaction	2.1	2.7	5.2	-0.7	0.7	-1.8	-1.5	-1.4	-2.1	-2.3	-1.0	-2.3	-1.0	-1.8	-1.9
Happiness	2.0	2.5	5.7	-1.0	-1.6	-0.6	-2.1	-2.2	-1.3	-2.4	-1.3	-0.4	-0.2	-1.6	-2.1
Migraine (self-reported)	2.0	2.5	4.3	-0.1	1.0	-1.7	-1.0	-1.2	-2.1	-2.0	-1.5	-1.7	-1.4	-2.1	-2.0
Illnesses of mother	1.9	2.4	4.6	-0.8	-0.9	-0.5	-1.3	-2.1	-0.7	-1.6	-1.9	-2.1	-1.9	-1.8	-1.4
Hair/balding pattern: Pattern 4	1.9	4.5	7.0	-1.4	-0.2	-2.2	-2.4	-2.3	-2.3	-2.4	-2.6	-2.0	-1.2	-2.5	-2.5
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.6	-0.4	-1.2	-1.1	-1.8	-2.3	-0.7	-1.4	-2.1	-2.4	-1.0	-1.6	-1.3
Schizophrenia vs Biploar Disorder	1.8	2.4	7.1	1.9	2.7	0.8	2.1	2.0	1.4	0.3	1.0	0.1	1.8	0.9	1.0
Schizophrenia (2014)	1.8	4.0	8.4	2.6	2.8	1.0	2.9	2.8	1.7	0.8	1.5	0.7	1.7	1.7	1.9
Hypothyroidism (self reported)	1.8	4.0	9.9	3.0	-0.7	2.3	1.6	1.4	2.0	1.1	1.2	3.1	2.1	2.0	2.1
Lung cancer (father)	1.8	2.1	4.8	-0.6	1.3	-1.0	-0.7	-0.8	-1.8	-1.9	-1.9	-1.0	-2.2	-1.8	-1.4
Emphysema/chronic bronchitis	1.8	2.1	3.8	-1.2	-0.1	-1.8	-1.1	-1.9	-1.8	-0.9	-1.0	-1.5	-2.0	-1.7	-1.0
Illnesses of siblings: Diabetes	1.8	2.2	3.7	-1.3	1.0	-1.7	-0.4	-1.4	-1.2	-1.2	-1.6	-1.9	-1.4	-1.9	-1.8
Heart disease (siblings)	1.8	2.2	4.3	2.1	0.1	1.3	1.4	1.3	1.0	1.7	1.2	2.0	0.5	1.7	2.0
Breast Cancer	1.7	4.0	10.0	-2.1	1.8	-2.5	-1.0	-1.5	-1.3	-2.2	-1.8	-2.3	0.0	-2.4	-3.2
Had menopause	1.7	2.2	5.4	0.1	0.0	1.8	2.3	1.8	2.1	1.2	1.2	1.0	1.1	1.7	1.4
Prospective memory result	1.7	2.0	5.1	0.7	0.4	-1.9	-1.8	-1.7	-1.4	-1.5	-0.7	-2.3	-1.2	-1.5	-0.8
Had major operations	1.7	2.0	3.8	-1.4	-2.0	1.4	1.3	0.7	1.5	1.8	1.7	0.9	1.1	1.6	1.1
Schizophrenia (2018)	1.6	3.2	6.4	2.4	2.4	0.8	2.4	2.5	1.6	0.9	1.6	0.8	1.8	1.6	1.6
Serious illness, injury or assault to yourself	1.6	1.9	5.6	-1.2	1.3	-1.1	-0.8	-0.6	-0.9	0.1	-1.6	-2.4	-2.3	-1.4	-0.9
Shortness of breath walking on level ground	1.6	1.9	4.0	0.1	0.0	-1.4	-0.5	-1.8	-2.0	-1.8	-1.6	-1.1	-1.2	-1.8	-1.5
Pain experienced in last month	1.6	2.7	6.0	0.5	1.0	2.2	2.0	2.4	1.9	1.6	0.7	2.3	0.8	1.6	1.1
Hair/balding pattern: Pattern 2	1.5	1.9	5.1	-0.0	0.6	1.1	1.3	1.8	1.1	1.1	1.3	2.2	1.9	1.5	1.2
Financial difficulties in last 2 years	1.5	2.0	5.3	-0.1	-1.8	-1.1	-2.0	-2.3	-1.3	-1.7	-0.8	-1.2	-0.9	-1.3	-1.0
Pain all over the body in last month	1.5	1.6	3.3	-1.7	-1.3	-1.3	-1.8	-1.7	-1.4	-1.0	0.1	-0.7	-0.9	-1.1	-1.1
Medication: Omeprazole	1.5	1.7	5.1	0.7	2.0	-1.6	0.2	-0.5	-1.0	-0.9	-2.2	-1.8	-0.7	-1.4	-1.0
Medication: Atenolol	1.4	1.7	4.9	2.2	1.8	0.4	1.9	1.1	-0.5	0.8	-0.4	2.1	1.3	0.3	-0.1
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.2	0.6	0.4	-1.0	-0.1	-1.5	-0.7	-0.9	-2.0	-1.9	-1.9	-1.5	-0.6
Illnesses of father: Heart disease	1.4	1.9	5.3	2.3	-0.6	1.3	1.5	0.8	1.7	0.4	0.5	1.5	2.3	1.1	0.7
Back pain experienced in last month	1.4	2.0	3.8	-0.0	-0.7	-1.7	-1.9	-1.9	-2.0	-0.3	-1.3	-1.8	-1.5	-1.3	-0.9
Sensitivity / hurt feelings	1.3	2.2	3.9	1.9	0.7	1.3	1.7	1.4	1.8	1.4	1.4	1.4	0.4	1.4	2.0
Ever had hysterectomy (womb removed)	1.3	1.5	4.4	-2.1	-0.2	-1.4	-0.3	-1.0	-1.1	-1.4	-1.0	-1.5	-0.5	-1.4	-1.3
Age when periods started (menarche)	1.3	3.2	7.7	-2.8	-0.8	-2.0	-2.5	-1.8	-1.8	-1.2	-1.2	-1.7	-0.8	-1.5	-2.2
Supplements: Glucosamine	1.3	1.7	4.4	-0.4	-0.7	-1.7	-1.7	-1.5	-1.1	-2.1	0.1	-1.9	-0.2	-1.2	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.6	-1.3	0.6	-1.9	-1.3	-0.7	-1.3	-1.0	-0.6	-1.5	-1.0	-1.3	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	3.6	1.9	1.5	1.2	1.5	1.5	0.4	1.4	0.9	1.0	1.0	1.0	1.1
Irritable Bowel Disease (IBD)	1.2	3.0	8.1	2.6	1.7	0.9	2.2	1.9	1.3	0.3	1.1	1.5	2.9	1.4	1.0
Blood White Count	1.2	8.9	65.4	3.5	8.1	0.2	3.7	3.8	-0.4	0.8	-0.8	-0.2	0.6	-0.2	-0.0
Number of full brothers	1.2	1.5	5.9	1.9	0.1	1.1	1.2	0.8	0.5	1.5	0.4	2.4	1.0	0.9	1.2
Chest pain or discomfort	1.2	1.7	6.4	-2.5	-0.6	-0.3	-0.4	-1.1	-0.3	-2.0	-1.6	-1.0	-0.2	-1.2	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	8.3	0.1	-1.1	-1.5	-2.9	-2.1	-1.5	-1.3	-1.1	-1.6	-1.4	-1.5	-1.2
Osteoarthritis (self-reported)	1.2	1.5	5.0	0.0	-0.1	-1.6	-1.5	-1.3	-1.1	-0.6	-0.7	-1.8	-2.2	-1.1	0.1
Fractured/broken bones in last 5 years	1.2	1.5	5.9	-2.4	-1.4	-0.9	-1.8	-1.2	-0.9	-1.0	-0.5	-0.6	-0.9	-0.9	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	5.9	0.8	2.4	-1.1	0.7	0.0	-0.6	-0.5	-2.0	-1.5	-0.3	-1.1	-0.8
Smoking Status	1.1	2.7	6.3	-1.6	-1.5	-2.0	-1.4	-2.5	-1.3	-1.6	-1.0	-1.9	-0.2	-1.6	-1.8
Average weekly fortified wine intake	1.1	1.3	4.8	-2.2	0.9	-0.7	0.5	0.4	-0.5	-1.3	-0.5	0.1	1.8	-0.5	-1.9
Had other major operations	1.1	1.3	4.8	-0.8	-0.4	-0.5	-0.7	-1.2	-0.7	-0.6	-1.5	-1.6	-2.2	-1.3	-1.1
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	7.1	2.2	-0.8	1.5	0.9	0.6	1.1	-0.1	1.0	2.7	1.5	1.4	1.4
Comparative body size at age 10	1.1	3.1	7.3	0.1	0.8	-1.0	-1.2	-1.7	-1.5	-2.2	-2.7	-1.9	-2.1	-2.4	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.9	-2.0	-1.2	-0.7	-0.9	-1.4	-1.4	-1.2	-1.6	0.4	-0.2	-1.4	-1.9
Medication: Gliclazide	1.1	1.2	2.5	0.1	0.7	-1.6	-0.8	-1.0	-1.3	-0.6	-1.3	-1.4	-0.9	-1.3	-1.1
Type 2 Diabetes (T2D) (2012)	1.0	1.2	3.7	0.6	0.1	-1.0	-0.1	-0.7	-1.0	-0.6	-1.5	-1.9	-1.9	-1.2	-0.5
Diabetes (mother)	1.0	1.3	3.0	1.0	0.4	0.4	0.3	1.2	0.7	0.5	1.5	1.7	1.7	1.4	1.3
Arm predicted mass (right)	1.0	5.1	11.5	-1.8	-1.2	-1.9	-2.2	-3.1	-3.4	-2.9	-1.4	-1.0	-1.5	-2.6	-2.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.0	0.7	-0.4	1.4	1.5	0.8	1.1	0.3	0.8	2.0	1.4	1.1	0.4
Ever had bowel cancer screening	1.0	1.2	4.8	-1.4	2.2	-0.1	1.1	0.8	-0.0	-0.4	-1.5	-0.4	-0.5	-0.8	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	4.0	-0.9	0.2	-1.6	-1.3	-0.5	-0.9	-0.2	0.7	-2.0	-1.2	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	1.0	1.2	5.9	-0.6	-2.4	-0.5	-1.7	-1.4	-0.9	-0.7	0.5	-1.2	-0.3	-0.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.8	-0.3	-0.5	-1.3	-1.7	-1.3	-1.2	0.5	-1.5	-0.5	-1.3	-1.3	-1.2
Intelligence (Savage-Jansen 2018)	0.9	2.8	5.7	-1.1	0.4	-2.0	-2.2	-1.6	-1.2	-1.4	-2.1	-1.8	-0.5	-1.9	-2.4
Body Mass Index (BMI) (2010)	0.9	1.3	2.8	-0.3	1.5	-1.2	-0.6	-0.7	-1.3	-0.6	-1.6	-0.2	-0.8	-1.7	-1.6
Blood Eosinophil Count	0.9	7.0	15.4	-2.0	-0.0	-2.5	-2.3	-2.9	-3.2	-2.9	-1.1	-3.9	-3.4	-3.0	-2.4
Number of treatments/medications taken	0.9	1.6	8.0	0.8	2.8	0.3	1.4	0.4	-0.3	-0.3	-1.4	-1.4	-1.8	-1.0	-0.3
Leg fat-free mass (left)	0.9	4.8	11.5	-1.2	-0.3	-2.2	-2.1	-2.7	-3.4	-2.7	-1.6	-1.4	-1.4	-2.6	-2.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.1	-0.5	-0.2	1.0	1.0	1.4	0.7	1.2	1.8	-0.2	0.1	1.1	1.5
Qualifications: CSEs or equivalent	0.9	1.1	3.3	-0.3	-0.7	-1.4	-1.8	-1.4	-1.8	-0.4	0.9	-0.5	-1.2	-0.6	0.2
Multivitamins +/- minerals	0.9	1.1	2.6	0.9	1.2	-1.5	-0.6	-0.8	-1.6	-1.2	-0.7	-1.0	-0.2	-1.1	-0.9
Leg predicted mass (left)	0.9	4.6	11.3	-1.1	-0.3	-2.2	-2.0	-2.6	-3.4	-2.7	-1.5	-1.3	-1.3	-2.6	-2.6
Weight	0.9	4.2	10.7	-1.3	0.8	-1.9	-1.2	-2.1	-3.3	-2.2	-2.0	-1.3	-1.3	-2.7	-2.8
Asthma	0.9	1.9	5.4	-0.4	-0.1	1.6	1.4	1.3	1.6	1.3	1.7	0.7	2.3	1.6	0.7
Arm fat-free mass (right)	0.9	4.8	10.8	-1.5	-0.7	-1.8	-2.1	-2.9	-3.3	-3.0	-1.6	-1.0	-1.2	-2.6	-2.8
Medication for pain relief, constipation, heartburn	0.9	1.5	3.5	1.0	0.8	0.8	1.2	1.7	1.1	1.9	1.2	1.0	0.8	1.4	1.2
Medication: Allopurinol	0.9	1.2	3.3	1.4	-0.7	-0.3	-0.8	-1.6	-0.6	-0.6	-1.4	-1.8	-0.9	-1.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	5.5	0.7	-0.7	1.4	0.2	1.4	1.2	1.0	1.4	2.4	1.5	1.8	1.3
Number of operations (self-reported)	0.9	1.3	3.9	-1.5	-0.5	-0.1	-0.5	-1.2	-0.7	-1.3	-0.6	-2.0	-1.4	-1.1	-1.3
Arm predicted mass (left)	0.9	4.5	10.5	-1.6	0.0	-1.7	-1.6	-2.4	-3.2	-2.9	-1.8	-0.9	-1.4	-2.7	-2.8
Alzheimer’s Disease (in mother)	0.8	0.9	3.7	-0.2	1.9	1.1	1.0	1.7	0.3	0.3	0.3	1.1	0.7	0.4	0.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.7	1.6	1.4	0.7	1.2	0.7	1.0	1.1	-0.6	-0.4	-0.1	0.3	0.3
Trunk fat mass	0.8	3.6	7.7	-1.0	1.9	-2.1	-0.6	-1.5	-2.8	-2.0	-2.0	-1.5	-0.9	-2.5	-2.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.9	-1.2	-0.8	-0.0	-0.2	-1.3	-0.5	-1.6	-1.1	-0.7	0.2	-1.2	-1.7
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.5	-1.6	0.5	-0.3	0.7	-0.5	-1.0	-0.4	-1.5	-0.2	-1.2	-1.3	-1.3
Leg fat-free mass (right)	0.8	4.2	10.5	-1.1	-0.6	-1.9	-2.0	-2.6	-3.2	-2.6	-1.4	-1.3	-1.4	-2.5	-2.4
Whole body water mass	0.8	4.7	11.4	-1.3	-0.7	-1.8	-2.1	-2.8	-3.4	-2.7	-1.6	-1.0	-1.5	-2.6	-2.6
Leg predicted mass (right)	0.8	4.3	10.7	-1.1	-0.6	-2.0	-2.0	-2.7	-3.3	-2.6	-1.4	-1.3	-1.4	-2.5	-2.4
Medication: Lisinopril	0.8	1.1	2.1	-1.5	-0.3	-0.5	-0.7	-1.1	-0.5	-0.9	-1.2	-1.3	-0.7	-1.4	-1.3
Basal metabolic rate	0.8	4.6	11.6	-1.3	-0.3	-1.9	-2.0	-2.6	-3.4	-2.6	-1.7	-1.1	-1.4	-2.7	-2.7
Ever depressed for a whole week	0.8	1.0	3.4	0.7	0.3	0.9	1.1	1.1	0.8	0.3	1.2	0.8	1.9	1.1	0.6
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.6	-1.9	-0.2	-1.3	-1.3	-1.0	-0.7	-0.7	-1.8	-1.7	-0.8	-1.4	-1.8
Triglycerides	0.7	1.2	4.7	1.2	2.2	-0.7	0.7	-0.0	-1.2	-0.6	-1.7	0.3	0.0	-1.2	-1.2
Chronotype (morning person)	0.7	1.7	4.2	-1.9	-2.0	-0.9	-0.8	-2.0	-1.0	-1.6	-0.3	-1.1	0.5	-1.0	-1.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.8	-0.0	0.1	-1.2	-0.2	-0.9	-0.7	-1.2	-1.2	-1.3	-1.3	-0.9	-0.6
Townsend deprivation index at recruitment	0.7	0.9	1.9	-0.2	-0.7	-0.8	-1.3	-1.4	-1.3	-1.4	-0.6	-0.2	-0.8	-1.1	-1.0
Current tobacco smoking	0.7	1.1	2.5	-0.7	-0.6	-1.2	-1.0	-1.6	-1.0	-1.3	-0.4	-0.7	0.1	-1.2	-1.4
High blood pressure (mother)	0.7	1.0	3.6	1.9	-0.7	0.2	0.2	0.3	0.1	1.0	1.3	1.2	0.3	1.1	1.5
Heart attack	0.7	0.8	2.5	0.5	1.6	-0.6	0.3	-0.5	-0.5	0.0	-1.6	-1.3	-0.3	-1.2	-0.7
Time employed in main current job	0.7	0.8	2.6	0.1	-1.5	-0.0	-0.4	-1.4	-0.7	-0.1	-0.4	-0.9	-1.6	-0.7	-0.1
Birth weight of first child	0.7	1.3	3.8	1.9	2.0	0.2	1.2	1.3	-0.2	0.4	1.0	0.6	-1.2	0.6	1.0
Pulse wave reflection index	0.7	0.9	3.3	-1.3	-1.8	0.3	-0.7	0.1	0.6	0.4	1.1	1.5	0.5	0.9	0.4
Worry too long after embarrassment	0.7	1.2	4.7	1.7	2.2	1.0	1.3	1.4	0.7	0.6	0.4	0.4	-0.5	0.3	0.8
Whole body fat mass	0.7	2.9	6.5	-0.7	1.8	-1.6	-0.3	-1.3	-2.5	-1.7	-2.0	-1.2	-0.8	-2.3	-2.4
Family relationship satisfaction	0.7	0.8	4.6	-0.8	-2.1	0.4	-0.9	-1.0	-0.2	-1.0	0.3	0.5	0.9	0.1	-0.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.5	0.5	0.4	1.2	1.1	1.2	1.1	0.9	0.6	0.8	1.0	1.0	1.2
Knee pain experienced in last month	0.7	1.0	2.8	-1.0	-0.0	-0.9	-0.5	-1.2	-0.4	-1.2	-1.4	-1.7	-0.6	-1.2	-0.9
Whole body fat-free mass	0.7	4.0	10.2	-1.2	-0.7	-1.6	-2.0	-2.6	-3.2	-2.6	-1.4	-0.9	-1.3	-2.4	-2.4
Loneliness, isolation	0.7	0.9	3.8	-0.1	-0.9	-0.9	-2.0	-1.3	-0.6	-1.2	-0.4	-0.9	-0.2	-0.8	-0.7
Qualifications: nursing, teaching	0.7	1.0	3.2	-1.7	-1.6	0.7	0.7	0.6	1.8	1.2	-0.2	0.4	0.5	0.8	0.2
Asthma (self-reported)	0.7	1.4	4.2	-0.5	-0.3	1.3	1.1	1.0	1.3	1.1	1.6	0.5	2.0	1.5	0.6
Osteoporosis (self-reported)	0.7	0.9	2.3	-0.2	1.5	1.5	1.4	1.3	1.0	0.4	0.7	0.3	0.8	0.6	0.4
Miserableness	0.7	1.3	4.0	-2.0	0.8	-1.0	-0.9	-0.4	-1.1	-1.9	-0.3	-0.6	-0.0	-1.0	-1.4
Basal cell carcinoma (self-reported)	0.7	0.9	5.2	-1.0	-2.3	0.1	-0.8	-1.2	0.5	-0.6	0.6	-0.5	1.0	-0.0	-0.5
Reaction Time	0.6	1.1	3.2	0.6	-0.4	-0.8	-1.0	-1.3	-0.7	-0.8	-1.8	-0.8	-1.6	-1.3	-0.3
Ovarian Cancer	0.6	0.8	3.3	-0.2	0.4	-0.8	-1.0	-0.9	-0.7	-1.8	-0.8	-0.5	-0.3	-0.9	-1.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.6	0.6	-0.3	1.2	1.1	0.9	1.0	1.2	0.2	0.5	-0.7	1.0	1.3
Supplements: Zinc	0.6	0.6	1.4	1.1	1.2	0.8	1.1	1.1	0.8	0.8	0.2	-0.1	0.5	0.4	0.5
Diabetes (father)	0.6	0.7	1.9	0.7	-1.2	-0.4	-1.1	-1.4	-0.9	-1.0	-0.5	-0.1	-0.7	-0.6	-0.6
Pack years adult smoking proportion	0.6	0.9	4.5	0.1	-1.0	0.6	0.7	0.2	1.1	0.1	2.1	-0.4	0.9	1.0	1.2
Trunk fat percentage	0.6	2.4	5.5	-0.7	2.4	-1.8	0.1	-0.7	-2.0	-1.4	-1.6	-1.4	-0.4	-1.9	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	3.2	0.8	1.0	-0.8	-0.8	-0.6	-0.7	-1.8	-0.6	-0.5	-0.1	-0.9	-0.7
Taking other prescription medications	0.6	0.9	3.8	0.3	2.0	1.0	1.4	1.2	0.4	0.9	-0.7	0.5	0.1	0.2	0.1
High blood pressure	0.6	1.6	5.3	2.2	2.3	0.8	1.9	1.3	1.0	0.9	-0.9	-0.2	0.2	0.3	0.4
Medication: Levothyroxine sodium	0.6	1.0	3.3	0.8	-1.8	0.7	-0.1	-0.7	0.3	-1.2	0.4	1.8	0.9	0.6	0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.6	-1.1	1.2	0.1	0.9	0.4	-0.4	-1.2	-0.4	-0.5	1.2	-0.4	-1.2
Medication: Simvastatin	0.6	0.8	2.8	0.5	0.4	0.7	1.7	0.8	1.0	1.6	0.5	-0.9	0.4	0.6	0.4
Fluid intelligence score	0.6	1.2	4.3	-2.1	-0.8	-0.4	-1.3	-0.8	-0.6	-1.0	-1.3	-0.8	-0.4	-1.0	-1.4
Alcohol intake versus 10 years previously	0.6	0.8	2.2	0.2	0.9	-1.5	-1.0	-0.8	-1.0	-0.9	-0.8	-1.0	-0.3	-1.2	-0.8
Noisy workplace	0.6	0.8	3.1	-1.8	0.3	-1.3	-0.5	-0.7	-0.7	-0.8	-0.0	-0.8	0.3	-0.5	-1.3
Depression (self-reported)	0.6	0.7	1.6	-0.9	0.2	-1.1	-0.7	-0.7	-0.9	-1.3	-0.6	-0.6	-0.9	-0.8	-0.6
Medication: Lansoprazole	0.6	0.6	1.9	-1.2	0.6	0.0	0.1	-0.2	-0.7	-1.4	-0.9	-0.7	-0.2	-0.7	-1.3
Arm fat mass (right)	0.6	2.3	5.4	-0.7	1.6	-1.4	-0.1	-1.1	-2.3	-1.4	-1.7	-1.1	-0.7	-2.1	-2.2
Exposure to tobacco smoke at home	0.6	0.7	2.1	-0.3	-1.5	-0.3	-1.1	-1.3	-0.0	-0.5	-1.0	-0.4	-1.0	-0.5	-0.2
Blood clot in the leg (DVT)	0.6	0.7	1.8	0.2	-0.5	-0.9	-1.3	-1.0	-0.8	0.7	-1.1	-0.1	-1.0	-0.9	-0.7
Body fat percentage	0.6	2.4	5.5	-0.7	2.4	-1.6	0.3	-0.8	-2.0	-1.3	-1.8	-1.4	-0.4	-2.0	-2.1
Number of children fathered	0.6	0.7	2.6	-0.9	0.3	-0.6	-0.5	-0.4	0.2	-0.7	-0.8	-1.6	-1.5	-0.7	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	3.0	-0.2	1.7	-0.2	1.2	1.2	0.5	0.9	-0.7	0.1	0.8	0.3	0.5
Angina (self-reported)	0.6	0.8	2.9	1.2	0.7	-0.2	0.7	-0.7	-1.1	-0.2	-1.7	0.1	-0.6	-1.2	-1.0
Leg fat mass (right)	0.6	2.5	5.7	-0.6	1.1	-1.5	-0.2	-1.5	-2.4	-1.6	-1.8	-1.1	-0.5	-2.2	-2.4
Number of full sisters	0.6	0.7	3.0	1.7	0.7	-0.2	0.2	-0.4	-0.7	-0.4	-0.7	1.5	-1.0	-0.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	4.2	-0.6	-2.0	0.9	-0.4	-0.8	0.4	0.5	-0.4	1.0	-0.6	0.1	0.4
Arm fat mass (left)	0.6	2.6	6.4	-0.5	1.8	-1.5	-0.2	-1.3	-2.5	-1.5	-1.9	-1.1	-0.7	-2.2	-2.3
Mother’s age at death	0.6	0.8	3.3	-0.1	0.5	1.1	0.5	0.9	1.0	0.2	0.3	1.8	1.1	0.9	0.4
Commuting to job workplace: Public transport	0.6	0.8	3.9	-0.3	-0.1	0.5	-0.2	0.6	0.7	0.8	0.5	2.0	1.6	0.8	0.0
Arm fat-free mass (left)	0.6	3.0	7.6	-1.3	-0.2	-1.2	-1.3	-2.1	-2.8	-2.3	-1.5	-0.5	-1.1	-2.2	-2.3
Average weekly beer plus cider intake	0.6	0.8	2.1	-0.3	0.6	-0.8	-0.8	-0.8	-1.4	-1.4	-0.4	-0.7	0.2	-1.2	-1.3
Risk taking	0.6	0.9	5.0	-1.2	-2.2	-0.7	-1.7	-0.7	-0.3	0.2	0.8	-0.2	0.5	0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.2	0.5	1.4	-0.7	0.3	-0.6	-0.5	0.1	-1.4	-1.5	-0.3	-1.1	-0.6
Pack years of smoking	0.6	0.8	3.6	0.2	-0.9	0.6	0.8	0.1	1.2	-0.1	1.9	-0.7	0.8	0.9	1.2
Bipolar Disorder (2018)	0.5	0.7	2.2	-1.1	-0.9	-1.0	-1.1	-1.1	-0.7	-0.3	-0.4	-1.5	-0.2	-0.5	-0.5
Crohns Disease (2012)	0.5	0.7	2.6	1.5	1.3	-0.5	0.9	0.1	0.0	-1.1	0.0	0.0	1.6	-0.2	0.1
Lupus	0.5	0.8	2.0	0.3	-0.0	-0.3	0.6	1.1	0.4	1.4	0.8	1.1	1.4	1.0	0.8
BMI	0.5	3.1	8.6	-0.3	0.4	-1.6	-0.9	-2.2	-2.9	-1.7	-1.7	-1.8	-1.1	-2.2	-2.2
Allergy or Eczema	0.5	1.4	3.8	-2.0	0.4	-0.6	-0.3	-0.5	-0.2	-0.6	-1.8	-1.6	-1.6	-1.2	-1.3
Respiratory disease	0.5	1.2	4.0	-0.0	-0.2	1.5	1.5	0.9	1.3	2.0	0.5	0.7	0.8	1.2	0.9
Angina	0.5	0.7	2.4	1.0	0.7	-0.1	0.7	-0.5	-1.1	-0.2	-1.5	0.1	-0.3	-1.1	-1.0
Medication for hormone replacement therapy	0.5	0.5	2.4	0.2	-0.4	0.4	-0.3	0.4	0.2	0.3	1.3	-0.3	-0.9	0.8	1.5
Medication: Co-codamol	0.5	0.6	2.6	-1.4	-0.6	0.0	0.0	0.1	0.8	-0.6	0.6	-1.6	-0.1	0.2	0.1
Mouth/teeth dental problems	0.5	0.8	3.4	-0.1	1.8	-0.1	0.6	1.3	1.0	0.5	0.2	-1.1	-1.2	0.3	0.6
Arm fat percentage (right)	0.5	1.8	5.6	-0.3	2.4	-1.3	0.5	-0.4	-1.9	-0.6	-1.6	-1.2	-0.6	-1.7	-1.8
Trunk fat-free mass	0.5	3.1	8.2	-1.2	-0.9	-1.1	-1.8	-2.3	-2.9	-2.2	-1.3	-0.4	-1.2	-2.1	-2.1
Mouth/teeth dental problems: Dentures	0.5	0.9	3.7	-0.9	-1.9	0.7	0.2	-0.2	0.2	0.5	1.6	0.1	0.5	0.8	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.1	-1.2	-0.3	-0.9	-1.4	-0.8	-0.3	-1.0	0.0	-0.7	0.4	-0.5	-0.7
Trunk predicted mass	0.5	3.1	8.1	-1.1	-0.8	-1.1	-1.8	-2.3	-2.9	-2.3	-1.3	-0.5	-1.2	-2.1	-2.1
Standing height	0.5	5.3	8.8	-1.5	0.1	-2.2	-2.7	-2.4	-3.0	-2.8	-2.2	-1.3	-2.2	-2.8	-2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.1	-0.7	1.3	-0.9	0.2	-0.2	-0.6	-1.0	-0.7	-0.3	1.3	-0.9	-1.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.5	0.4	-1.6	-0.2	-1.1	-1.3	-0.6	-0.7	-0.5	0.6	0.4	-0.4	-0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	4.5	-2.1	-1.6	-0.4	-1.1	-0.4	-0.5	-0.8	0.6	0.8	0.4	0.0	-0.7
Gout (self-reported)	0.5	0.7	2.0	1.3	-1.1	0.4	-0.2	-1.4	-0.7	-0.7	-0.7	-1.0	-0.5	-0.8	-0.2
Medication: Blood pressure	0.5	0.8	2.8	1.7	1.5	-0.4	0.2	-0.2	-0.3	-0.0	-1.1	-1.2	-1.1	-0.7	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.1	0.8	-0.3	0.5	1.1	0.5	0.9	0.1	-0.7	0.8	1.5	0.7	0.2
Arm fat percentage (left)	0.5	2.0	4.2	-0.4	2.0	-1.5	0.1	-0.8	-2.1	-0.9	-1.7	-1.1	-0.6	-1.9	-1.9
Commuting to job workplace: Walk	0.5	0.5	1.4	0.1	-1.0	0.8	-0.5	0.3	-0.3	0.6	1.2	1.2	0.2	0.6	0.6
Smoking status: Current	0.5	0.9	2.2	-0.6	-0.7	-1.2	-0.7	-1.5	-0.8	-1.1	-0.4	-0.7	0.2	-1.1	-1.3
Diastolic blood pressure, automated reading	0.5	1.7	6.9	0.5	0.7	1.5	2.6	1.6	1.5	1.2	1.0	0.1	0.4	1.1	1.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.1	-2.0	-1.9	-1.0	-1.9	-1.1	-0.9	-1.1	1.0	0.1	0.0	-0.2	-0.5
Leg fat mass (left)	0.5	2.0	5.3	-0.5	1.0	-1.2	-0.1	-1.4	-2.3	-1.4	-1.7	-0.8	-0.5	-2.0	-2.1
Bipolar Disorder or Schizophrenia	0.4	1.0	1.7	1.1	1.3	-0.0	1.3	1.3	0.8	0.5	1.0	-0.3	1.2	1.0	0.9
Depressed Affect (Nagel 2018)	0.4	0.9	1.9	-0.7	-0.8	-0.5	-1.4	-1.1	-0.8	-1.1	-0.8	-0.7	-1.1	-1.0	-1.1
Alzheimer’s Disease (in father)	0.4	0.5	1.4	0.9	-1.2	0.3	0.1	-0.8	0.5	-1.0	0.0	-0.7	-1.0	-0.1	0.3
Alzheimer’s Disease (including proxy)	0.4	0.6	3.1	0.6	1.8	0.9	1.1	1.1	0.3	0.2	-0.3	0.6	0.1	0.0	0.1
HDL Cholesterol	0.4	0.7	1.6	-0.9	-1.3	0.8	-0.8	-0.1	0.8	0.7	1.1	-0.5	-0.7	0.7	1.0
Neuroticism (2016)	0.4	0.6	1.7	-0.2	1.1	0.2	0.3	0.1	-0.4	-1.0	-0.7	0.7	1.1	-0.6	-1.3
Primary Biliary Cirrhosis	0.4	0.6	3.3	-1.0	-1.8	0.1	-0.7	0.0	0.2	0.6	0.7	0.3	-0.2	0.7	0.7
Hearing difficulty/problems: Yes	0.4	0.7	1.9	-1.4	-0.8	-0.9	-1.0	-0.8	-1.2	-0.5	0.3	-0.6	0.3	-0.4	-0.7
Systolic blood pressure, automated reading	0.4	1.1	4.9	0.4	1.7	0.6	2.2	1.3	1.2	1.0	0.0	0.2	-0.2	0.4	0.5
Hand grip strength (right)	0.4	1.0	3.7	1.0	-0.2	0.8	0.1	0.8	0.3	1.1	1.4	1.3	1.9	1.0	0.5
Stomach or abdominal pain in last month	0.4	0.5	1.8	0.3	-0.8	-0.2	0.6	-0.0	0.3	-0.9	1.3	-0.8	0.8	0.5	0.3
Alcohol usually taken with meals	0.4	0.7	3.2	-1.2	-0.3	0.3	-0.2	-0.7	0.5	-0.4	-1.8	0.2	0.2	-0.6	-1.4
Diabetes (self-reported)	0.4	0.7	1.5	-0.2	0.1	-0.4	-0.9	-1.0	-1.0	-0.5	-1.2	-0.8	-0.7	-1.1	-1.0
Medication: Ramipril	0.4	0.6	1.9	0.4	-0.1	-0.5	-1.2	-0.8	-0.9	-0.3	-0.6	-1.4	-0.7	-0.7	-0.6
Hip circumference	0.4	1.8	5.9	-0.7	1.5	-1.4	0.0	-0.9	-2.4	-1.2	-1.1	-0.7	-0.1	-1.8	-2.0
Medication: Cholesterol lowering	0.4	0.6	2.4	1.5	1.0	0.7	1.5	0.1	0.4	0.9	-0.6	-0.4	0.1	-0.1	0.3
Length of working week for main job	0.4	0.5	2.4	0.1	-0.7	-0.2	-0.3	-0.9	-0.0	-0.5	-1.6	-0.1	-1.1	-0.6	-0.4
High blood pressure (siblings)	0.4	0.6	1.9	0.5	-0.2	0.2	1.0	0.7	0.9	-0.1	0.7	0.7	1.4	1.1	0.7
Leg fat percentage (right)	0.4	1.4	3.2	-0.7	1.5	-1.1	0.6	-0.7	-1.6	-0.8	-1.4	-1.0	-0.1	-1.6	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	2.9	-1.7	-0.8	0.4	0.3	-0.5	0.1	-1.1	-0.8	-0.2	0.5	-0.5	-0.7
Overall health rating	0.4	0.8	4.1	-0.9	0.9	-0.5	-0.4	-0.6	-0.7	-0.7	-0.4	-2.0	-0.5	-0.9	-0.7
Age at last live birth	0.4	0.5	1.4	-1.2	-1.0	0.2	-0.3	0.5	0.7	0.3	1.1	0.9	-0.0	1.0	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	3.6	0.1	-1.9	0.6	-0.2	-0.8	0.0	-0.6	0.3	0.4	-0.3	0.2	0.0
Hypertension (Self-reported)	0.4	1.1	4.0	2.0	2.0	0.6	1.5	0.9	0.7	0.5	-0.8	-0.3	-0.1	0.2	0.4
Medication for cholesterol	0.4	0.6	2.5	0.7	0.3	-1.6	-0.8	-0.7	-1.2	-0.7	-0.4	-0.6	0.2	-0.7	-0.6
Mineral and other dietary supplements	0.4	0.6	1.5	-0.9	-0.4	1.0	0.0	0.5	0.4	0.9	0.6	1.2	-0.1	0.8	1.0
Breast cancer (self-reported)	0.4	0.5	4.0	-0.3	-0.0	0.0	0.6	-0.4	0.5	0.6	-2.0	-0.2	-0.6	-0.6	-0.3
Number of self-reported non-cancer illnesses	0.4	0.7	3.0	0.2	0.7	0.6	1.2	-0.2	0.4	-0.2	-1.7	-1.2	-0.7	-0.8	-0.5
Average weekly champagne plus white wine intake	0.4	0.6	2.0	0.2	0.6	0.8	1.0	0.8	1.4	0.8	-0.2	0.8	0.5	0.5	0.5
Ever taken oral contraceptive pill	0.4	0.4	1.7	1.3	-1.0	-0.2	0.1	0.1	0.4	0.3	0.6	0.5	0.9	0.7	0.4
Hearing aid user	0.4	0.5	3.8	-0.3	-2.0	0.3	0.0	-0.7	0.0	-0.0	-0.2	0.3	-1.0	-0.1	0.3
High cholesterol (Self-reported)	0.4	0.7	2.5	0.1	-0.5	-0.5	0.2	-1.4	-0.8	-0.7	-0.4	-1.6	-0.7	-1.0	-0.9
Age started oral contraceptive pill	0.4	0.6	1.3	-0.5	-0.1	0.9	1.1	1.0	1.0	-0.3	0.4	1.0	0.7	0.7	0.5
Myopia	0.4	0.6	5.0	2.2	0.4	0.1	0.6	0.1	0.1	0.9	-0.2	0.5	-0.5	0.3	0.4
Alcohol drinker status: Previous	0.4	0.5	1.5	-0.8	0.6	-0.6	0.4	-0.7	-0.3	-0.7	-0.7	-0.8	0.5	-0.8	-1.2
Depression (Nagel 2018)	0.3	0.5	3.1	1.1	1.8	-0.2	0.1	0.3	-0.3	-0.8	-0.2	-0.4	-0.4	-0.3	-0.1
Neuroticism (Nagel 2018)	0.3	0.6	1.6	0.8	0.1	-0.1	-0.6	-0.8	-0.5	-0.9	-1.1	-0.8	-1.3	-0.9	-0.8
Crohns Disease (2017)	0.3	0.8	5.1	2.2	1.2	-0.3	0.8	0.1	-0.2	-1.1	0.2	-0.6	0.4	-0.2	0.0
Fasting Glucose	0.3	0.3	2.0	-1.4	-0.4	0.6	0.0	-0.0	0.7	0.3	-0.3	-0.4	-0.3	-0.1	-0.5
Cardiovascular Disease	0.3	0.9	3.1	1.8	0.7	-0.3	-0.1	-0.9	-0.4	-0.7	-1.5	-1.2	-1.0	-0.9	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	3.2	0.7	0.2	-0.3	-0.2	-0.7	-0.5	-0.6	-0.9	-1.8	-0.5	-0.8	-0.6
Lung FEV1/FVC ratio	0.3	1.3	4.0	2.0	0.2	1.3	0.7	1.3	1.0	1.1	0.7	0.9	0.9	1.3	1.3
Average weekly spirits intake	0.3	0.4	1.9	-0.7	-1.4	-0.3	-0.8	-0.7	-0.8	-0.5	0.1	0.2	-0.2	-0.1	-0.6
Relative age of first facial hair	0.3	0.7	3.9	-2.0	-0.7	-0.8	-0.7	-0.7	-0.6	-0.4	0.6	-0.9	-0.4	-0.3	-0.7
Vitamin and mineral supplements	0.3	0.4	1.5	-1.2	-1.2	0.1	-1.1	-0.5	-0.2	0.0	0.0	-0.0	-1.0	-0.2	-0.1
Medication: Metformin	0.3	0.4	1.1	0.9	-1.0	-0.3	-0.7	-1.0	-0.2	-0.5	-0.3	-0.7	0.3	-0.4	-0.5
Severe depression (siblings)	0.3	0.3	1.3	0.6	1.1	-0.0	0.6	0.9	0.3	-0.2	0.5	0.5	0.2	0.5	0.4
Fed-up feelings	0.3	0.6	1.4	0.2	-0.7	1.2	0.5	0.5	1.0	0.7	0.9	1.0	0.7	0.8	0.6
Relative age voice broke	0.3	0.4	1.0	-0.8	0.6	-0.9	-0.5	-0.4	-1.0	-0.6	-0.4	-0.2	-0.1	-0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.5	0.5	1.2	-0.2	1.0	0.4	-0.1	-1.0	-0.5	0.1	-0.0	-0.2	-0.8
Sitting height	0.3	2.5	5.8	-0.9	-0.1	-1.3	-2.4	-1.7	-2.1	-1.9	-1.1	-0.8	-1.3	-1.9	-1.9
Body mass index (BMI)	0.3	1.2	3.9	-0.6	0.8	-0.8	0.1	-1.1	-2.0	-1.0	-1.1	-0.6	-0.3	-1.5	-1.7
Waist circumference	0.3	0.9	3.8	-0.8	-0.2	-0.7	-0.2	-1.2	-1.9	-0.5	-0.8	-0.4	-0.3	-1.2	-1.3
Past tobacco smoking	0.3	0.5	4.0	0.3	2.0	-0.3	-0.1	1.0	-0.6	-0.5	0.8	0.1	-0.1	-0.0	-0.1
Number of live births	0.3	0.4	1.9	-0.2	-1.4	0.0	0.7	-0.3	0.3	0.1	1.0	-0.5	-0.3	0.6	0.7
Pulse rate	0.3	0.5	1.4	0.5	-0.1	1.1	1.2	0.2	0.7	0.0	0.8	-0.6	0.8	0.6	0.7
Tense / ‘highly strung’	0.3	0.5	1.4	-0.6	-0.0	-0.5	-0.7	-0.7	-0.8	-1.2	-0.7	-0.7	-0.6	-0.8	-1.0
Medication: Paracetamol	0.3	0.5	2.5	-0.9	-1.0	-0.2	-0.3	-0.9	-0.6	-1.6	-0.2	-0.4	-0.6	-0.5	-0.3
Headache pain in last month	0.3	0.5	1.2	0.7	0.5	-0.9	-0.4	-0.7	-1.0	-1.0	-0.4	-1.1	0.1	-0.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.3	-1.5	-0.0	-0.2	-0.1	-0.1	0.1	-0.3	-0.7	-0.6	-1.3	-0.4	-0.4
Eye problems/disorders: None of the above	0.3	0.3	1.1	-0.5	-1.0	0.4	-0.3	0.0	0.3	-0.3	0.6	0.7	1.1	0.4	0.1
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.7	1.3	0.7	-0.2	0.1	0.2	-0.1	0.4	-0.3	0.7	0.8	0.1	0.0
Neck or shoulder pain in last month	0.3	0.4	2.6	-0.7	-1.6	-0.0	-0.9	-1.0	-0.3	-0.3	-0.1	0.3	0.2	-0.3	-0.1
Mean time to correctly identify matches	0.3	0.6	3.9	-0.0	-0.1	0.1	-0.0	-0.6	-0.1	-0.2	-2.0	-0.2	-1.5	-0.9	-0.4
Heart disease (mother)	0.3	0.4	2.0	0.1	0.2	-1.4	0.5	0.3	-0.1	0.7	0.7	-0.3	1.1	0.4	-0.1
Suffer from ‘nerves’	0.3	0.5	1.2	1.0	0.7	0.6	1.1	0.6	0.4	0.1	0.8	-0.1	0.9	0.5	1.0
Medication: Aspirin	0.3	0.4	1.5	0.3	1.2	-0.7	-0.2	0.0	-0.9	-0.4	-0.3	-0.6	-0.2	-0.7	-0.6
Smoking status: Previous	0.3	0.5	3.0	-0.6	-1.7	0.6	0.1	-0.6	0.6	0.6	-0.6	0.2	-0.2	0.2	0.4
Diabetes diagnosed by doctor	0.3	0.5	1.2	0.3	-0.5	-0.3	-0.8	-1.1	-0.5	-0.7	-1.1	-1.0	-0.6	-0.8	-0.8
Eye problems/disorders: Cataract	0.3	0.4	2.6	0.1	-1.6	0.4	-0.4	-0.6	0.4	0.3	0.0	1.0	-0.1	0.3	0.3
Medication: Blood pressure	0.3	0.5	1.4	-0.3	1.2	1.1	1.0	0.7	0.6	0.2	-0.7	0.9	0.4	-0.1	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	1.2	0.5	-0.9	0.5	-0.2	-0.5	-0.3	-0.5	-0.6	-0.5	-0.5	-0.2
Medication: Bendroflumethiazide	0.3	0.5	3.0	0.6	0.4	0.9	1.7	0.2	0.9	0.6	-0.4	-0.1	-0.3	0.1	0.1
Alcohol drinker status: Never	0.3	0.4	1.9	-0.4	0.5	0.2	0.1	0.1	0.2	0.1	-1.3	-0.1	-1.4	-0.5	-0.1
Leg fat percentage (left)	0.3	1.1	2.5	-0.6	1.4	-0.7	0.8	-0.6	-1.6	-0.6	-1.3	-0.8	-0.1	-1.4	-1.6
Worry (Nagel 2018)	0.2	0.4	1.2	0.8	-0.2	0.1	0.0	-0.5	-0.2	-1.0	-1.0	-0.7	-1.1	-0.5	-0.4
Major Depression (MDD)	0.2	0.2	0.9	0.0	0.0	0.0	0.0	0.0	0.0	-0.3	-0.9	0.6	0.8	-0.2	-0.7
Age at First Birth	0.2	0.3	0.9	-0.5	-0.2	-0.5	-0.9	-0.3	-0.1	-0.8	0.7	-0.9	-0.1	-0.2	-0.1
Coronary Artery Disease (CAD)	0.2	0.2	0.6	-0.4	-0.8	-0.0	-0.3	0.0	0.4	0.3	0.6	0.2	0.7	0.4	0.2
Mean Putamen Volume	0.2	0.2	1.5	-0.1	-0.4	0.1	0.5	-0.1	0.5	1.2	0.4	0.0	-0.4	0.3	0.6
HbA1C	0.2	0.2	2.1	-1.5	0.2	-0.4	-0.4	0.1	0.0	0.3	-0.0	-0.2	0.1	0.1	0.1
Rheumatoid Arthritis	0.2	0.2	0.8	0.6	0.9	-0.9	0.0	-0.2	0.2	-0.2	-0.7	-0.2	-0.6	-0.4	-0.1
Waist Hip Ratio (WHR)	0.2	0.9	2.3	0.4	-1.5	0.9	0.3	0.2	0.8	1.4	0.3	1.4	0.3	1.2	1.1
Systolic Blood Pressure	0.2	1.2	6.6	1.6	2.6	-0.3	1.3	0.8	0.5	0.8	-0.8	-0.5	-0.7	-0.3	0.0
Neuroticism	0.2	0.5	1.1	0.4	0.7	-0.4	-0.4	-0.5	-0.7	-0.9	-0.9	-0.3	-1.0	-0.9	-0.7
Hand grip strength (left)	0.2	0.5	1.8	0.7	-0.2	0.6	0.3	0.6	-0.2	1.1	0.6	1.4	0.8	0.5	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	0.2	0.6	-0.1	-0.5	-0.6	-0.3	-0.6	-0.7	-0.9	-0.6	-0.8	-0.4
Impedance of leg (right)	0.2	0.7	2.3	0.2	1.4	0.4	0.6	1.5	1.4	0.7	0.3	0.4	0.7	0.8	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.9	-1.7	-0.0	-0.4	0.0	0.3	0.4	0.2	-0.6	-1.0	0.0	-0.1	-0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	1.2	0.3	0.1	0.2	0.9	0.1	0.3	-0.3	-0.5	1.1	0.0	0.2	-0.0
Impedance of leg (left)	0.2	0.8	2.2	0.2	1.1	0.7	0.8	1.5	1.4	0.8	0.5	0.5	0.8	0.9	0.7
Number of incorrect matches in round	0.2	0.3	0.9	0.4	1.0	-0.6	0.0	-0.1	-0.4	-0.6	-0.7	-0.2	0.5	-0.7	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-0.1	-0.3	-0.1	-0.8	-0.6	-0.3	-1.0	-0.3	-0.7	0.5	-0.4	-0.7
Forced vital capacity (FVC)	0.2	0.6	2.8	-0.6	-0.8	0.0	-1.7	-0.6	-1.1	-0.8	-0.2	0.5	-0.5	-0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.5	1.2	-1.0	0.6	-0.7	-0.1	0.4	0.2	0.5	0.5	-0.4	0.6	0.7
Qualifications: None of the above	0.2	0.5	2.4	0.9	1.6	0.1	1.0	0.3	-0.4	0.4	-0.9	0.2	-0.1	-0.4	-0.0
Allergy	0.2	0.6	3.5	1.9	-0.1	0.4	0.0	0.0	-0.2	-0.6	1.1	0.4	-0.4	0.3	1.0
Illnesses of siblings	0.2	0.3	1.7	-0.1	-0.4	-0.2	-1.3	-0.5	-0.5	-0.2	-0.2	-0.7	-0.8	-0.6	-0.4
Impedance of arm (right)	0.2	1.1	2.8	0.8	1.7	0.2	0.9	1.6	1.6	1.2	0.1	-0.4	0.4	0.7	1.0
Father’s age at death	0.2	0.3	1.0	-0.1	-1.0	-0.6	-0.9	-0.8	0.3	-0.5	-0.1	-0.7	-0.3	-0.1	-0.0
Worrier / anxious feelings	0.2	0.3	1.8	0.2	0.6	-0.2	0.5	0.1	0.3	-1.3	-0.1	-0.6	0.2	-0.3	-0.6
Hair/balding pattern: Pattern 3	0.2	0.2	0.9	0.9	0.1	-0.1	0.2	0.4	0.3	0.3	0.7	-0.9	-0.3	0.2	0.4
Breastfed as a baby	0.2	0.3	0.7	-0.4	-0.8	-0.4	-0.8	-0.8	-0.2	0.4	0.4	-0.7	-0.1	0.0	-0.3
Peak expiratory flow (PEF)	0.2	0.4	1.2	-0.0	-1.0	0.3	-1.1	-0.5	-0.7	-0.0	-0.1	1.0	0.3	-0.2	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.1	-0.1	-0.7	-0.5	-0.3	-0.3	-0.7	0.0	-0.5	0.4	-0.3	-0.6
Medication: Amlodipine	0.2	0.3	1.4	1.2	1.1	0.5	0.6	0.5	0.4	0.0	-0.3	-0.3	0.5	0.2	-0.0
Birth weight	0.2	0.5	1.8	-0.1	0.6	-0.7	0.6	0.3	-0.5	-1.2	1.4	-0.4	1.0	0.4	0.3
Forced vital capacity (FVC), Best measure	0.2	0.7	2.2	-0.7	-0.1	-0.4	-1.5	-0.4	-1.3	-1.1	-0.4	0.2	-0.8	-0.8	-0.9
Age at first live birth	0.2	0.4	2.0	-0.2	-0.7	-0.1	-0.6	0.5	0.4	0.4	0.7	1.4	0.3	0.8	0.4
Pulse wave peak to peak time	0.2	0.3	0.7	0.7	-0.6	-0.2	-0.8	-0.6	-0.8	0.1	-0.2	-0.2	-0.6	-0.4	0.0
Qualifications: College or University degree	0.2	0.5	2.6	-0.4	-1.6	0.5	-0.7	-0.4	1.0	-0.3	-0.8	0.2	-0.8	0.0	-0.3
Pulse rate, automated reading	0.2	0.7	3.6	0.0	0.4	1.1	1.9	0.8	1.1	0.8	0.3	0.5	0.4	0.5	0.5
Alcohol intake frequency.	0.2	0.4	1.0	0.5	0.3	-0.7	0.2	-1.0	-0.6	-0.9	-0.2	-0.8	-0.9	-0.7	-0.2
Comparative height size at age 10	0.2	1.1	2.4	-0.5	0.8	-0.6	-0.7	-0.9	-1.4	-1.5	-1.5	-0.0	-1.5	-1.3	-0.7
Supplements: Vitamin C	0.2	0.3	1.0	-0.3	0.2	0.5	1.0	0.5	1.0	0.3	-0.1	-0.1	0.6	0.2	0.2
Average weekly red wine intake	0.2	0.3	1.4	-0.8	-0.2	-0.2	-0.3	-0.2	0.2	0.5	-1.2	0.0	-0.1	-0.3	-1.0
Mood swings	0.2	0.4	1.8	0.2	-0.1	-0.3	-0.9	-0.8	-0.8	-1.4	0.2	-0.3	-0.3	-0.8	-0.6
Friendships satisfaction	0.2	0.2	1.0	0.6	-0.6	0.1	-0.4	-1.0	-0.6	-0.4	0.2	-0.1	0.2	-0.5	-0.3
Guilty feelings	0.2	0.4	2.8	1.7	0.4	0.7	0.3	0.1	-0.1	0.0	-0.2	0.5	-0.4	-0.2	0.4
Wears glasses or contact lenses	0.2	0.2	0.8	-0.7	-0.2	0.4	0.1	0.3	0.1	0.3	0.9	0.2	-0.5	0.5	0.5
Medication: Paracetamol	0.2	0.3	1.1	-0.9	-0.3	-0.3	0.1	-0.5	-0.9	-0.7	-0.3	-0.5	-1.1	-0.5	-0.1
Medication: Atorvastatin	0.2	0.2	0.8	0.6	-0.9	0.0	-0.2	-0.6	-0.1	0.2	0.0	0.3	0.8	-0.1	0.1
Illnesses of father: High blood pressure	0.2	0.3	0.7	-0.8	-0.8	0.6	0.3	0.0	0.6	0.3	0.8	-0.3	-0.4	0.5	0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	-0.8	-0.6	-0.7	-0.8	-0.2	-0.0	0.2	-0.1	-0.4	-0.5	-0.2	-0.0
Commuting to job workplace: Cycle	0.2	0.3	1.4	-0.7	-1.2	0.4	-0.7	0.1	0.2	-0.1	0.7	-0.1	-0.3	0.4	0.4
Cholesterol lowering medication	0.2	0.3	1.6	-1.3	-0.8	0.1	0.6	-0.2	0.1	-0.2	0.5	-0.9	0.1	0.0	-0.2
Supplements: Calcium	0.2	0.2	0.9	0.1	0.2	0.7	-0.0	0.1	1.0	-0.3	-0.7	0.3	0.6	-0.2	-0.7
Impedance of whole body	0.2	0.9	3.0	0.4	1.7	0.3	0.8	1.7	1.4	0.8	0.2	-0.1	0.6	0.7	0.7
LDL Cholesterol	0.1	0.2	0.7	0.5	0.8	-0.1	0.7	0.4	-0.6	-0.1	-0.4	0.1	-0.1	-0.3	-0.2
Blood Red Count	0.1	0.7	2.4	-0.3	1.0	0.8	1.6	1.2	1.1	-0.0	0.5	0.4	0.8	0.7	0.3
Height	0.1	2.7	7.5	-2.7	-1.1	-1.4	-2.1	-1.8	-1.9	-2.0	-0.4	-0.1	-0.8	-1.6	-1.9
Lung FVC	0.1	0.6	2.7	-0.3	-1.5	1.1	-0.1	0.1	0.3	-0.2	0.3	1.6	0.3	0.4	0.3
Tanning	0.1	0.7	2.9	-0.3	0.0	-1.1	-0.8	-0.9	-0.9	-0.7	-0.4	-1.7	-0.4	-0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.1	1.0	-0.8	1.1	-0.3	0.0	0.5	-0.1	-0.2	0.7	-0.4	0.4	0.3
Nervous feelings	0.1	0.2	0.9	0.9	0.4	0.6	0.9	0.1	0.4	-0.4	-0.0	-0.1	-0.5	-0.0	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.2	0.4	-0.3	-0.6	-0.4	-0.5	-0.8	-0.4	-0.4	-0.2	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.7	-0.0	-0.7	0.5	-1.3	-0.1	-0.8	-0.5	0.2	1.1	0.1	-0.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.5	-1.2	-1.0	-0.3	-0.5	-0.4	-0.3	-0.3	-0.2	0.6	0.2	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.3	-0.3	-0.1	0.2	-1.2	0.0	-1.0	-0.6	-0.0	0.7	-0.4	-0.3	-0.4
Pulse wave Arterial Stiffness index	0.1	0.2	0.9	-0.9	0.4	0.1	0.6	0.3	0.5	-0.3	-0.1	0.2	0.3	0.1	-0.3
Impedance of arm (left)	0.1	0.6	2.4	0.4	1.6	-0.4	0.2	1.2	1.0	0.9	0.1	-0.7	0.1	0.4	0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	-0.9	-0.0	-0.1	-0.3	-0.1	0.4	-0.6	-0.2	-0.3	-0.7	-0.0	-0.0
Medication: Ibuprofen	0.1	0.1	0.3	-0.5	0.2	-0.2	-0.4	0.2	0.3	-0.2	0.6	-0.1	0.4	0.1	0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.5	0.4	0.1	-0.2	0.7	0.1	-0.1	-0.1	-0.0	0.5	-0.4	0.0	0.1
Medication: Aspirin	0.1	0.2	1.3	0.3	1.2	-0.2	0.3	0.6	-0.4	-0.0	0.1	0.1	0.4	-0.2	-0.1
Ever smoked	0.1	0.2	0.8	0.2	-0.7	0.2	0.5	-0.5	0.3	0.6	-0.6	0.0	0.9	-0.0	-0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.2	1.4	-0.6	1.2	0.5	0.2	0.7	0.1	0.2	0.3	-0.4	0.2	-0.1	-0.2
Heel T-Score	0.0	0.1	0.3	0.2	0.5	0.2	-0.1	0.2	-0.3	-0.4	0.1	0.2	-0.1	-0.1	-0.3
Hair Pigment	0.0	0.1	0.5	0.3	-0.3	-0.2	-0.3	-0.5	-0.3	-0.4	-0.4	0.7	-0.2	-0.2	-0.2
Neuroticism score	0.0	0.1	0.4	0.5	0.4	0.4	0.1	0.0	0.3	-0.6	0.1	0.1	-0.2	-0.2	0.1

Hub : Genes

FCN1

Models

Trait associations