TWAS hub - FCN3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.341	0.141	0.00820	-0.009	NA	-0.004	NA	-0.007	6.8e-01	NA	4.4e-01	NA	5.8e-01
2	GTEx	Stomach	0.360	0.080	0.00011	0.268	NA	0.187	NA	0.247	3.6e-13	NA	2.5e-09	NA	3.9e-12
3	TCGA	Thyroid Carcinoma	0.030	0.017	0.00420	0.030	0.017	0.006	NA	0.015	6.1e-04	0.008	7.2e-02	NA	1.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3
Vascular/heart problems diagnosed by doctor	4.9	13.5	38.3	-1.4	-6.2
High blood pressure	4.6	12.8	35.0	1.8	5.9
Hypertension (Self-reported)	4.1	11.4	32.0	1.5	5.7
Illnesses of father: High blood pressure	3.6	4.5	12.3	1.1	3.5
Medication: Amlodipine	3.5	4.9	13.3	-1.2	3.7
Medication: Bendroflumethiazide	3.4	5.1	12.9	1.6	3.6
Osteoporosis (self-reported)	3.0	3.7	10.6	-0.7	3.2
Illnesses of father: Heart disease	2.8	3.8	7.5	-2.0	2.7
Cardiovascular Disease	2.6	8.7	26.1	0.4	5.1
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	6.7	-2.6	1.6
Medication: Blood pressure	2.5	4.7	13.0	1.1	3.6
Systolic Blood Pressure	2.4	11.9	35.5	0.3	6.0
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	8.8	-0.1	3.0
Pulse wave Arterial Stiffness index	2.3	2.6	6.0	2.4	-1.4
Medication: Atenolol	2.2	2.7	8.1	-0.3	2.9
Handedness (chirality/laterality): Left-handed	2.2	2.6	7.6	-2.8	-0.6
Hair/balding pattern: Pattern 2	2.1	2.7	5.4	-1.7	2.3
Pulse wave peak to peak time	2.0	2.4	5.4	-2.3	1.3
Medication: Co-codamol	1.9	2.2	6.4	0.3	-2.5
Medication for cholesterol	1.9	2.9	8.5	-0.2	-2.9
Commuting to job workplace: Public transport	1.9	2.2	3.5	-1.9	1.8
Ever had prostate specific antigen (PSA) test	1.9	2.2	5.0	-2.2	-1.3
Prostate Cancer	1.6	2.2	5.2	1.2	-2.3
Systolic blood pressure, automated reading	1.6	4.6	13.9	0.2	3.7
Stomach or abdominal pain in last month	1.6	2.0	3.6	-1.9	1.6
Alcohol intake versus 10 years previously	1.6	2.4	5.5	1.3	2.3
Average weekly fortified wine intake	1.5	1.7	2.8	1.7	-1.6
High blood pressure (mother)	1.5	2.1	4.3	1.4	2.1
Had other major operations	1.5	1.8	4.8	0.8	2.2
Father’s age at death	1.5	2.0	3.9	-1.5	-2.0
Alcohol intake frequency.	1.5	3.4	10.2	-0.2	3.2
Illnesses of father: None of the above (group 1)	1.5	1.8	5.1	0.5	-2.3
High cholesterol (Self-reported)	1.5	2.6	4.2	-2.1	1.9
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.5	1.0	2.1
Angina	1.4	1.8	3.5	1.9	1.4
Lung cancer (father)	1.4	1.7	4.7	2.2	0.6
Breastfed as a baby	1.4	1.7	3.8	1.2	1.9
Wheeze or whistling in the chest in last year	1.4	2.5	7.3	0.4	2.7
Medication: Blood pressure	1.4	2.4	7.3	0.2	2.7
Angina (self-reported)	1.4	1.9	3.5	1.9	1.5
Medication: Aspirin	1.4	1.8	5.5	0.1	2.3
Maternal smoking around birth	1.3	1.9	5.6	-0.1	-2.4
Supplements: Glucosamine	1.3	1.6	4.9	0.3	-2.2
Gout (self-reported)	1.3	1.8	4.1	2.0	1.2
Number of full sisters	1.3	1.6	4.7	2.2	0.2
Knee pain experienced in last month	1.3	2.0	6.0	-0.0	-2.5
Financial situation satisfaction	1.3	1.7	2.5	1.6	1.6
Reaction Time	1.2	2.3	4.5	-2.1	-1.5
Mean Putamen Volume	1.2	1.3	3.0	-1.7	1.0
Heart attack	1.2	1.6	4.7	0.1	2.2
Prospective memory result	1.2	1.5	3.3	1.8	-1.1
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.5	1.6	-1.3
Medication: Ventolin 100micrograms inhaler	1.2	1.5	4.1	0.7	2.0
Number of children fathered	1.2	1.3	3.5	1.9	-0.7
Mean time to correctly identify matches	1.2	2.3	4.5	-2.1	-1.6
Family relationship satisfaction	1.2	1.4	3.7	0.8	1.9
Medication: Lisinopril	1.2	1.5	2.8	-1.3	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.2	-1.8	1.1
Shortness of breath walking on level ground	1.1	1.3	3.8	-0.0	2.0
Medication: Allopurinol	1.1	1.4	3.5	0.9	1.9
Heart disease (mother)	1.1	1.3	3.9	-0.3	2.0
Chest pain or discomfort	1.1	1.6	4.2	-0.7	2.1
Hearing difficulty/problems: Yes	1.0	1.5	4.2	-2.1	0.5
Medication: Ramipril	1.0	1.3	3.6	0.4	1.9
Illnesses of mother	1.0	1.2	3.5	-1.9	-0.5
Exposure to tobacco smoke outside home	1.0	1.3	3.8	-0.3	-1.9
Cholesterol lowering medication	1.0	1.5	3.9	-0.7	2.0
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.8	0.3	2.0
Schizophrenia vs Biploar Disorder	0.9	1.1	3.4	0.0	-1.8
Lung FEV1/FVC ratio	0.9	4.4	9.7	-1.9	-3.1
Hair/balding pattern: Pattern 3	0.9	1.4	2.6	1.2	-1.6
Leg pain on walking	0.9	1.1	3.2	1.8	0.4
Mineral and other dietary supplements	0.9	1.2	3.6	0.2	1.9
Medication: Gliclazide	0.9	1.1	1.9	1.1	-1.4
Alcohol drinker status: Never	0.9	1.1	3.2	1.8	0.2
Commuting to job workplace: Cycle	0.9	1.1	2.0	-1.4	1.1
Alcohol drinker status: Previous	0.9	1.0	2.0	-1.0	1.4
HDL Cholesterol	0.8	1.3	2.9	1.0	-1.7
Taking other prescription medications	0.8	1.2	3.5	0.2	1.9
Medication: Levothyroxine sodium	0.8	1.4	4.0	-0.3	2.0
Sitting height	0.8	6.0	17.9	0.1	4.2
Chronic bronchitis/emphysema (father)	0.8	0.9	2.6	-0.3	-1.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.8	1.7	0.5
Medication: Simvastatin	0.8	1.2	2.3	-1.5	1.1
Time employed in main current job	0.8	0.9	2.6	1.6	-0.3
Glaucoma (self-reported)	0.8	1.0	1.9	1.0	-1.4
Long-standing illness, disability or infirmity	0.8	1.2	2.7	1.0	1.6
Number of self-reported non-cancer illnesses	0.8	1.4	3.9	0.5	2.0
Average weekly champagne plus white wine intake	0.8	1.1	2.7	0.7	-1.6
Ulcerative Colitis (UC)	0.7	1.3	3.8	-1.9	-0.4
HbA1C	0.7	0.8	2.3	-0.2	-1.5
Average weekly spirits intake	0.7	0.8	2.0	1.4	0.7
Qualifications: CSEs or equivalent	0.7	1.0	1.8	-1.4	-1.0
Impedance of leg (left)	0.7	3.6	9.9	-1.0	3.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.4	-0.8	1.6
Worrier / anxious feelings	0.7	1.4	4.1	-2.0	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.1	1.4	0.6
Pulse wave reflection index	0.7	0.8	2.0	0.7	-1.4
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.4	-1.1	1.2
Migraine (self-reported)	0.7	0.8	1.9	-0.7	-1.4
Medication: Omeprazole	0.7	0.9	2.6	0.2	1.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.7	1.3	-0.8
Medication: Aspirin	0.7	0.9	2.6	0.1	1.6
Loneliness, isolation	0.7	1.0	1.7	1.3	1.1
Ever had bowel cancer screening	0.7	0.8	2.5	-0.2	-1.6
Fasting Glucose	0.6	0.8	2.3	-1.5	-0.1
Allergy or Eczema	0.6	1.5	4.4	2.1	0.2
Number of treatments/medications taken	0.6	1.1	2.8	-0.8	1.7
Sensitivity / hurt feelings	0.6	1.0	3.0	0.3	-1.7
Impedance of leg (right)	0.6	2.7	7.1	-1.0	2.7
Had menopause	0.6	0.8	1.7	0.8	-1.3
Happiness	0.6	0.8	2.2	-1.5	0.4
Medication: Cholesterol lowering	0.6	0.9	1.5	-1.2	1.1
Medication: Lansoprazole	0.6	0.7	1.0	1.0	-1.0
Blood clot in the leg (DVT)	0.6	0.8	2.2	-1.5	-0.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.9	0.3	-1.4
High blood pressure (siblings)	0.6	0.8	2.5	0.0	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.7	-0.9	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	-1.4	-0.3
Health satisfaction	0.6	0.7	2.2	-0.1	1.5
Pulse rate, automated reading	0.6	1.9	2.9	1.7	-1.7
Had major operations	0.6	0.7	1.3	0.9	-1.1
Friendships satisfaction	0.6	0.8	2.0	1.4	-0.5
Eye problems/disorders: Cataract	0.6	0.7	1.3	0.9	1.2
Breast cancer (self-reported)	0.6	0.8	1.6	-1.3	0.8
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.9	-0.6	-1.4
Number of operations (self-reported)	0.6	0.9	1.8	1.4	0.9
Fractured/broken bones in last 5 years	0.6	0.8	1.7	-0.9	-1.3
Diastolic blood pressure, automated reading	0.6	1.9	4.8	0.9	2.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.3	-1.5	-0.3
Irritable Bowel Disease (IBD)	0.5	1.2	3.2	-1.8	-0.7
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.8	0.5	-1.3
Severe depression (siblings)	0.5	0.6	1.0	-1.0	0.8
Age when periods started (menarche)	0.5	1.3	2.0	1.3	-1.4
Body mass index (BMI)	0.5	2.2	4.7	1.4	-2.2
Number of live births	0.5	0.7	1.7	0.5	-1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	0.8	-1.4
Headache pain in last month	0.5	0.9	2.5	-1.6	-0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.3	0.5	-1.5
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.4	0.6	1.6
Comparative body size at age 10	0.5	1.3	3.8	2.0	0.2
Worry too long after embarrassment	0.5	0.8	1.4	-1.2	-1.1
Medication for pain relief, constipation, heartburn	0.5	0.9	2.4	0.5	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	1.3	0.1
Smoking status: Previous	0.5	0.8	1.4	1.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.6	1.3	1.3
Back pain experienced in last month	0.5	0.7	2.0	0.1	1.4
Guilty feelings	0.5	0.7	2.1	-1.4	0.2
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.6	-1.2	-0.3
Medication: Atorvastatin	0.5	0.6	1.6	-0.4	1.3
Irritability	0.5	0.8	1.2	-1.1	-1.1
Impedance of whole body	0.5	2.6	4.9	-1.7	2.2
Lupus	0.4	0.6	1.3	-0.7	1.1
Primary Biliary Cirrhosis	0.4	0.6	1.9	0.0	1.4
Blood Eosinophil Count	0.4	2.8	8.0	0.8	2.8
Blood Platelet Count	0.4	5.1	14.8	-0.7	3.9
BMI	0.4	2.1	6.4	-0.1	-2.5
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.5	1.6	0.2
Waist circumference	0.4	1.6	4.7	0.2	-2.2
Past tobacco smoking	0.4	0.8	1.8	-1.4	0.7
Arm fat mass (right)	0.4	1.6	4.0	0.9	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.9	-0.2	-1.4
Qualifications: College or University degree	0.4	1.1	2.0	-1.4	1.2
Medication: Seretide 50 evohaler	0.4	0.4	0.8	0.7	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	1.1	-0.5
Leg fat mass (right)	0.4	1.6	2.8	1.5	-1.7
Overall health rating	0.4	0.9	2.1	0.8	1.4
Arm fat percentage (left)	0.4	1.7	4.7	0.7	-2.2
Diabetes diagnosed by doctor	0.4	0.6	1.1	0.8	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.4	-0.8	1.2
Arm fat mass (left)	0.4	1.8	4.4	1.0	-2.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	0.8	0.9
Risk taking	0.4	0.6	1.7	-0.5	1.3
Supplements: Calcium	0.4	0.4	0.9	-1.0	0.5
Leg fat mass (left)	0.4	1.7	2.6	1.5	-1.6
Bipolar Disorder (2018)	0.3	0.5	1.4	0.0	1.2
Depressed Affect (Nagel 2018)	0.3	0.6	1.2	1.1	0.8
Depression (Nagel 2018)	0.3	0.5	1.4	0.3	1.2
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.4	-1.0
Age at First Birth	0.3	0.4	1.3	-1.1	-0.1
LDL Cholesterol	0.3	0.5	0.9	0.9	0.9
Schizophrenia (2014)	0.3	0.6	1.7	0.0	-1.3
Heel T-Score	0.3	2.5	6.3	1.1	-2.5
Smoking Status	0.3	0.7	2.0	0.1	-1.4
Respiratory disease	0.3	0.7	1.1	1.1	0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.0	0.6	-1.0
Medication for hormone replacement therapy	0.3	0.4	0.7	0.9	-0.6
Diabetes (mother)	0.3	0.4	1.1	1.0	-0.4
Leg fat-free mass (left)	0.3	1.6	3.2	1.2	-1.8
Current tobacco smoking	0.3	0.5	1.1	-0.6	-1.1
Relative age voice broke	0.3	0.4	1.2	-1.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.8	-0.0	-1.3
Multivitamins +/- minerals	0.3	0.3	0.7	-0.5	-0.9
Leg predicted mass (left)	0.3	1.6	3.3	1.2	-1.8
Nervous feelings	0.3	0.6	1.0	-0.9	1.0
Allergy	0.3	0.7	2.0	-1.4	0.2
Diabetes (self-reported)	0.3	0.5	0.9	0.9	-0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	0.6	-0.8
Illnesses of siblings	0.3	0.4	0.9	1.0	-0.6
Impedance of arm (right)	0.3	1.5	3.0	-1.7	1.2
Arm fat percentage (right)	0.3	1.3	3.5	0.7	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	0.6	1.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	1.0	-0.5
Impedance of arm (left)	0.3	1.4	3.5	-1.9	0.8
Birth weight of first child	0.3	0.6	1.4	-0.7	1.2
Arm fat-free mass (right)	0.3	1.7	4.3	2.1	-0.9
Whole body fat mass	0.3	1.3	2.7	1.1	-1.6
Suffer from ‘nerves’	0.3	0.4	1.1	-1.1	0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	-0.4	-1.0
Average weekly red wine intake	0.3	0.5	1.4	0.3	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.9	0.9	0.5
Asthma (self-reported)	0.3	0.6	1.2	1.1	0.7
Osteoarthritis (self-reported)	0.3	0.4	0.7	0.6	-0.8
Arm predicted mass (left)	0.3	1.5	4.2	2.0	-0.6
Schizophrenia (2018)	0.2	0.4	1.3	0.0	-1.1
Crohns Disease (2017)	0.2	0.5	1.3	-1.1	-0.5
Major Depression (MDD)	0.2	0.3	0.8	0.0	0.9
Ovarian Cancer	0.2	0.2	0.6	0.1	-0.8
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.8	-0.4
Crohns Disease (2012)	0.2	0.4	1.1	0.0	-1.0
Neuroticism (2016)	0.2	0.3	0.9	0.9	0.4
Triglycerides	0.2	0.3	0.7	-0.3	-0.9
Blood Red Count	0.2	2.3	5.1	1.4	2.3
Waist Hip Ratio (WHR)	0.2	0.8	2.2	0.2	-1.5
Lung FVC	0.2	0.9	1.8	-1.0	-1.3
Neuroticism	0.2	0.5	1.0	-0.7	1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	0.1	0.7
Supplements: Zinc	0.2	0.2	0.7	-0.1	-0.8
Pack years adult smoking proportion	0.2	0.3	0.9	1.0	-0.0
Hand grip strength (right)	0.2	0.5	1.4	0.4	1.2
Alcohol usually taken with meals	0.2	0.3	0.6	0.8	-0.5
Pain all over the body in last month	0.2	0.2	0.5	0.2	0.7
Weight	0.2	1.2	2.1	1.2	-1.5
Falls in the last year	0.2	0.2	0.6	-0.4	0.7
Noisy workplace	0.2	0.2	0.3	-0.6	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.1	-0.5	-1.1
Asthma	0.2	0.5	0.9	0.9	0.7
Peak expiratory flow (PEF)	0.2	0.4	0.9	0.9	0.6
Birth weight	0.2	0.4	1.2	1.1	0.0
Leg fat percentage (right)	0.2	0.9	1.4	1.2	-1.1
Emphysema/chronic bronchitis	0.2	0.3	0.7	0.8	-0.2
Arm predicted mass (right)	0.2	0.8	2.1	1.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.6	0.4
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.7	-0.3
Leg fat-free mass (right)	0.2	1.1	2.0	1.2	-1.4
Smoking status: Current	0.2	0.4	0.6	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.3	-0.3	-1.1
Whole body water mass	0.2	1.0	1.9	1.4	-1.1
Leg predicted mass (right)	0.2	1.1	1.9	1.2	-1.4
Wears glasses or contact lenses	0.2	0.2	0.5	-0.7	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.6	-0.6
Hearing aid user	0.2	0.2	0.5	0.4	0.7
Medication: Paracetamol	0.2	0.4	0.9	-0.5	0.9
Ever smoked	0.2	0.3	0.5	0.7	-0.6
Basal metabolic rate	0.2	1.2	2.0	1.4	-1.2
Leg fat percentage (left)	0.2	0.8	1.7	1.3	-0.9
Arm fat-free mass (left)	0.2	1.1	3.0	1.7	-0.6
Age started oral contraceptive pill	0.2	0.3	0.8	0.9	-0.1
Pack years of smoking	0.2	0.3	0.8	0.9	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	-0.0	-0.8
Worry (Nagel 2018)	0.1	0.2	0.3	-0.6	0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.2	0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.4	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.6	-0.6
Rheumatoid Arthritis	0.1	0.1	0.4	0.0	0.6
Ulcerative Colitis	0.1	0.2	0.5	0.0	-0.7
Hypothyroidism (self reported)	0.1	0.3	0.7	0.3	0.9
Chronotype (morning person)	0.1	0.3	0.5	0.6	0.7
Hand grip strength (left)	0.1	0.2	0.6	0.3	0.8
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.2	0.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.2	0.4
Medication: Metformin	0.1	0.1	0.2	0.5	0.2
Diabetes (father)	0.1	0.1	0.3	0.5	-0.3
Trunk fat percentage	0.1	0.3	0.6	0.5	-0.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.5	-0.1	0.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.4	-0.2
Trunk fat mass	0.1	0.6	1.3	0.7	-1.1
Number of incorrect matches in round	0.1	0.2	0.4	0.7	-0.3
Financial difficulties in last 2 years	0.1	0.2	0.4	-0.6	-0.2
Neuroticism score	0.1	0.2	0.6	-0.7	-0.0
Trunk fat-free mass	0.1	0.7	1.8	1.3	-0.5
Pulse rate	0.1	0.2	0.6	0.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	-0.5	-0.2
Trunk predicted mass	0.1	0.7	1.8	1.4	-0.5
Standing height	0.1	0.8	2.2	-0.3	1.5
Length of working week for main job	0.1	0.1	0.4	0.0	0.6
Exposure to tobacco smoke at home	0.1	0.2	0.4	0.7	-0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	0.9	-0.2
Loud music exposure frequency	0.1	0.1	0.1	0.4	-0.3
Medication: Paracetamol	0.1	0.2	0.4	-0.7	0.1
Body fat percentage	0.1	0.6	1.2	0.7	-1.1
Number of full brothers	0.1	0.1	0.2	-0.4	-0.5
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.0	-0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	-0.1	-0.6
Neck or shoulder pain in last month	0.1	0.2	0.5	-0.7	-0.2
Medication: Ibuprofen	0.1	0.1	0.3	0.2	0.6
Supplements: Vitamin C	0.1	0.1	0.4	-0.6	0.0
Whole body fat-free mass	0.1	0.9	1.7	1.3	-0.9
Mood swings	0.1	0.1	0.3	0.6	-0.1
Qualifications: nursing, teaching	0.1	0.1	0.3	0.2	-0.5
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.3	-0.4
Miserableness	0.1	0.2	0.5	0.2	0.7
Mother’s age at death	0.1	0.2	0.5	0.2	0.7
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.5	-0.3
Ever depressed for a whole week	0.1	0.1	0.2	0.4	0.5
Unable to work because of sickness or disability	0.1	0.1	0.2	0.3	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.4	-0.5
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.0	-0.2
Neuroticism (Nagel 2018)	0.0	0.0	0.0	-0.1	0.1
Breast Cancer	0.0	0.1	0.1	-0.4	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.0	0.0	-0.2	-0.1
Height	0.0	0.9	2.5	-0.3	1.6
Hair Pigment	0.0	0.4	1.2	0.1	1.1
Tanning	0.0	0.5	1.5	-0.0	1.2
Relative age of first facial hair	0.0	0.1	0.1	-0.3	0.3
Vitamin and mineral supplements	0.0	0.0	0.1	0.3	0.1
Townsend deprivation index at recruitment	0.0	0.1	0.2	0.0	-0.4
Fed-up feelings	0.0	0.0	0.0	0.2	-0.0
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.0	0.3
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.4	0.3
Forced vital capacity (FVC)	0.0	0.1	0.2	0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.2	-0.4
Qualifications: None of the above	0.0	0.1	0.2	-0.0	0.5
Mouth/teeth dental problems	0.0	0.0	0.0	-0.0	-0.2
Fluid intelligence score	0.0	0.1	0.3	0.0	-0.5
Hip circumference	0.0	0.1	0.2	0.5	-0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.1	-0.3	-0.0
Depression (self-reported)	0.0	0.0	0.0	0.2	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	-0.2	0.5
Tense / ‘highly strung’	0.0	0.1	0.1	0.3	-0.3
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	0.3	0.2
Age at first live birth	0.0	0.1	0.1	-0.1	-0.4
Comparative height size at age 10	0.0	0.0	0.1	0.2	-0.1
Age at last live birth	0.0	0.0	0.1	0.4	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.2	0.1
Average weekly beer plus cider intake	0.0	0.0	0.1	-0.3	-0.2
Myopia	0.0	0.1	0.2	0.5	0.0
Pain experienced in last month	0.0	0.0	0.1	0.3	0.0
Heart disease (siblings)	0.0	0.0	0.1	-0.0	-0.4

Hub : Genes

FCN3

Models

Trait associations