TWAS hub - FER

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.095	0.0310	3.9e-05	0.006	0.033	0.044	0.034	0.003	5.3e-02	6.5e-05	4.6e-06	4.8e-05	1.1e-01
2	GTEx	Artery Aorta	0.234	0.0660	3.4e-05	0.154	NA	0.181	NA	0.180	7.7e-09	NA	3.2e-10	NA	3.6e-10
3	GTEx	Artery Coronary	0.343	0.1110	5.3e-04	0.097	NA	0.080	NA	0.125	3.8e-04	NA	1.2e-03	NA	5.4e-05
4	GTEx	Artery Tibial	0.142	0.0453	8.5e-05	0.062	NA	0.051	NA	0.046	1.2e-05	NA	7.3e-05	NA	1.5e-04
5	TCGA	Uterine Corpus Endometrial Carcinoma	0.409	0.1320	4.0e-03	0.007	0.051	-0.008	NA	0.014	2.0e-01	1.5e-02	6.0e-01	NA	1.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Forced vital capacity (FVC), Best measure	7.2	26.3	40.2	-3.4	6.1	5.5	6.3	3.6
Forced vital capacity (FVC)	6.9	26.7	43.7	-3.2	6.6	5.7	6.3	2.6
Illnesses of mother	6.5	8.0	13.2	-2.5	2.9	3.6	3.4	0.5
Hearing difficulty/problems: Yes	6.4	9.8	17.4	1.9	4.2	3.6	3.6	1.3
Impedance of arm (left)	5.9	27.4	41.9	-6.5	4.8	5.4	5.8	3.0
Impedance of arm (right)	5.3	24.6	40.8	-6.4	4.3	5.2	5.6	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	5.3	16.9	30.7	-1.7	5.5	4.5	5.1	2.2
Systolic blood pressure, automated reading	5.2	15.0	23.5	1.8	-4.7	-4.6	-4.8	-2.3
Forced expiratory volume in 1-second (FEV1)	5.1	17.1	33.4	-1.4	5.8	4.6	5.2	1.6
Maternal smoking around birth	4.8	6.9	14.0	0.3	-3.4	-3.7	-2.9	0.3
Family relationship satisfaction	4.7	5.7	11.1	0.8	2.5	3.3	2.5	2.1
Hand grip strength (left)	4.6	12.1	23.6	-1.0	4.9	4.0	4.5	-0.4
Standing height	4.5	44.3	67.5	-4.4	8.2	7.1	7.8	4.9
Forced expiratory volume in 1-second (FEV1), predicted	4.4	9.2	19.0	-1.7	4.4	2.8	3.3	2.2
Height	4.2	80.1	129.0	-5.8	11.4	10.0	10.7	4.8
Systolic Blood Pressure	4.2	21.2	34.8	2.5	-5.4	-5.4	-5.9	-2.6
Lung cancer (father)	4.1	4.8	11.3	0.4	1.7	3.1	3.4	-0.2
Impedance of whole body	4.0	20.3	30.4	-5.5	3.9	4.9	5.1	2.5
Comparative height size at age 10	3.9	21.5	28.0	-3.8	5.3	5.1	5.2	3.5
Chest pain or discomfort	3.8	5.5	11.3	3.4	-2.1	-1.9	-2.5	1.5
Hand grip strength (right)	3.4	9.1	16.6	-1.2	4.1	3.4	3.9	-0.6
Migraine (self-reported)	3.4	4.3	7.2	-1.6	1.5	2.1	2.3	2.7
Eye problems/disorders: Glaucoma	3.4	4.0	10.0	0.5	-3.2	-1.8	-2.5	0.5
Bipolar Disorder (2011)	3.3	3.2	5.7	1.4	-2.0	-2.0	-2.4	0.0
Lupus	3.3	4.9	11.1	0.1	-1.6	-3.2	-3.3	-0.7
Coronary Artery Disease (CAD)	3.2	3.9	9.7	0.3	-3.1	-2.1	-2.0	-1.1
Eye problems/disorders: None of the above	3.0	3.5	4.7	-2.0	2.2	1.6	2.1	-1.4
Commuting to job workplace: Public transport	2.9	3.4	7.0	0.1	-1.5	-2.6	-2.5	-1.2
Glaucoma (self-reported)	2.7	3.1	8.0	0.9	-2.8	-1.5	-2.1	0.3
Fasting Glucose	2.6	3.1	4.8	1.3	2.2	1.9	1.6	-1.5
Chronic bronchitis/emphysema (father)	2.6	3.1	5.7	0.6	2.3	2.0	2.4	-0.1
Peak expiratory flow (PEF)	2.6	6.0	12.3	-0.6	3.5	2.4	3.0	1.5
Cholesterol lowering medication	2.6	3.8	5.7	1.0	-2.3	-2.0	-2.4	-1.7
Angina	2.5	3.3	6.3	-0.4	-2.5	-1.9	-1.9	-1.6
Impedance of leg (right)	2.4	11.4	21.1	-2.5	3.2	4.4	4.6	0.6
Heart disease (mother)	2.4	2.9	5.3	0.9	-2.3	-2.1	-1.6	-1.3
Blood White Count	2.3	16.8	29.3	3.2	-5.4	-4.0	-4.7	-2.6
Time employed in main current job	2.3	2.7	8.4	-2.9	-0.1	-1.0	-1.6	1.2
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	5.0	1.0	1.0	2.2	2.2	-0.4
Angina (self-reported)	2.1	2.7	5.2	-0.1	-2.3	-1.7	-1.6	-1.7
Prostate Cancer	2.0	2.8	9.5	-0.4	0.6	1.0	1.7	3.1
Stomach or abdominal pain in last month	2.0	2.4	3.6	1.2	-1.8	-1.6	-1.1	1.9
Friendships satisfaction	2.0	2.5	7.0	-0.7	1.1	1.3	1.5	2.7
Lung FEV1/FVC ratio	1.9	9.4	23.0	4.8	-2.4	-2.4	-2.6	-2.5
Hair/balding pattern: Pattern 2	1.9	2.4	5.5	0.6	1.2	2.4	2.1	0.7
Impedance of leg (left)	1.8	8.7	14.1	-3.0	2.6	3.5	3.8	1.0
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.7	0.8	2.2	2.1	1.5	0.3
Exposure to tobacco smoke at home	1.8	2.0	3.2	1.7	-1.8	-1.4	-1.0	-0.8
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.8	-0.2	1.1	1.8	2.0	1.4
Long-standing illness, disability or infirmity	1.8	2.7	6.8	2.4	-2.6	-0.6	-0.6	0.2
Worry too long after embarrassment	1.7	2.9	10.5	3.2	0.7	1.4	0.9	0.8
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	4.4	-0.8	2.1	1.7	1.4	-0.8
Handedness (chirality/laterality): Left-handed	1.7	2.0	4.1	0.4	-0.8	-1.7	-1.5	-2.0
Average weekly fortified wine intake	1.6	1.9	6.6	0.4	1.3	0.9	0.4	2.6
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	6.9	2.6	-0.8	-0.6	-0.5	-0.7
Medication: Simvastatin	1.6	2.4	4.3	1.2	-2.1	-1.6	-1.7	-1.0
Pulse rate	1.6	2.7	4.7	1.6	-1.9	-1.0	-1.3	2.2
Medication: Lansoprazole	1.6	1.8	5.4	1.2	-2.3	-1.3	-0.7	0.3
Comparative body size at age 10	1.6	4.4	9.6	-0.0	-2.2	-3.1	-2.7	-0.0
Happiness	1.5	1.9	4.4	-0.3	0.6	1.3	1.7	2.1
Breastfed as a baby	1.5	1.9	5.3	1.6	-1.2	-0.4	-0.2	-2.3
Chronic bronchitis/emphysema (mother)	1.5	1.7	3.2	0.3	-1.3	-1.8	-1.7	-0.7
Mineral and other dietary supplements	1.5	2.0	3.4	1.1	-1.7	-1.5	-1.8	0.1
Average weekly champagne plus white wine intake	1.5	2.1	3.0	-1.3	-1.5	-1.7	-1.7	-0.6
Miserableness	1.5	2.5	5.4	1.0	-1.3	-2.3	-2.0	0.8
Crohns Disease (2017)	1.4	3.1	6.2	-0.5	-1.7	-2.5	-2.4	0.6
Crohns Disease (2012)	1.4	2.2	4.4	-0.7	-1.0	-2.0	-2.1	0.9
Sensitivity / hurt feelings	1.4	2.4	4.6	0.5	-1.2	-2.1	-2.1	-1.1
Supplements: Glucosamine	1.4	1.8	4.7	-0.3	0.9	2.2	1.8	-0.3
Body mass index (BMI)	1.4	6.1	9.9	3.1	-1.9	-2.8	-3.0	-0.6
Pulse wave reflection index	1.4	1.7	4.8	0.3	2.2	1.2	1.5	0.1
Medication for cholesterol	1.4	2.1	4.0	-0.0	1.6	1.6	2.0	1.3
Wears glasses or contact lenses	1.4	1.6	3.6	0.5	-1.0	-1.7	-1.9	-0.7
Vascular/heart problems diagnosed by doctor	1.4	3.7	6.2	-1.2	2.2	2.4	2.5	0.8
Blood Platelet Count	1.3	14.9	26.2	1.5	-4.5	-5.0	-5.1	-0.9
Chronotype (morning person)	1.3	3.0	5.5	-0.7	-0.9	-2.4	-1.8	-2.2
Hearing difficulty/problems with background noise	1.3	2.1	2.9	1.4	1.2	1.4	1.7	1.4
Financial difficulties in last 2 years	1.3	1.8	2.7	1.4	-1.6	-1.6	-1.3	0.0
Length of working week for main job	1.3	1.4	4.5	2.1	0.7	1.1	0.4	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.6	0.2	-1.8	-1.9	-1.5	1.0
Blood clot in the leg (DVT)	1.3	1.7	4.1	1.0	1.0	1.3	2.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.3	0.9	1.5	1.2	1.4	1.3
Medication: Blood pressure	1.3	2.4	3.5	1.2	-1.5	-1.8	-1.9	-1.3
Bipolar Disorder (2018)	1.2	1.8	2.9	1.6	-1.3	-1.7	-1.5	-0.1
Neuroticism (2016)	1.2	1.7	3.2	0.9	-0.6	-1.8	-1.5	-1.3
Ulcerative Colitis	1.2	1.7	3.8	-0.9	-0.9	-1.6	-0.9	-1.9
BMI	1.2	6.8	9.6	3.0	-2.4	-3.1	-2.9	-1.2
Cardiovascular Disease	1.2	3.8	5.1	2.2	-1.5	-2.2	-2.3	-1.3
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.8	-1.1	-0.8	-1.7	-1.6	-0.9
Number of live births	1.2	1.7	2.8	0.7	-1.5	-1.7	-1.4	0.8
Medication: Ibuprofen	1.2	1.4	2.8	-0.5	1.7	1.3	1.3	0.7
Medication: Allopurinol	1.2	1.6	2.6	0.0	-0.7	-1.6	-1.5	-1.6
Pulse rate, automated reading	1.2	4.0	6.7	2.5	-2.6	-2.0	-1.7	0.3
Hypertension (Self-reported)	1.2	3.3	4.5	2.0	-1.9	-2.0	-2.1	-0.6
Qualifications: nursing, teaching	1.2	1.8	4.1	1.2	2.0	1.2	1.1	-0.9
Osteoarthritis (self-reported)	1.2	1.6	2.7	1.4	-0.6	1.6	1.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	8.4	-0.7	2.9	1.3	1.4	0.6
Heart disease (siblings)	1.2	1.4	5.7	0.5	-2.4	-0.2	-0.6	0.8
Alzheimer’s Disease (including proxy)	1.1	1.5	3.9	1.1	0.2	-1.4	-2.0	-0.9
Breast Cancer	1.1	2.7	10.2	1.7	-0.4	-0.5	-0.0	-3.2
Lung FVC	1.1	5.7	8.6	-2.0	2.9	2.1	2.7	2.1
Current tobacco smoking	1.1	1.8	2.8	1.7	-1.6	-1.4	-1.2	-0.4
High blood pressure	1.1	3.2	4.7	1.8	-1.9	-2.0	-2.2	-0.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.1	-0.1	1.8	0.9	1.5	-0.6
Falls in the last year	1.1	1.5	5.2	-0.7	0.3	1.2	0.7	2.3
Hair/balding pattern: Pattern 3	1.1	1.7	2.8	0.0	-1.7	-1.5	-1.6	-0.6
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	6.6	0.3	0.5	0.2	0.4	-2.6
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.4	-1.6	-0.9	-1.4	-1.2	0.6
Illnesses of father: Heart disease	1.1	1.5	3.3	1.8	-1.2	-0.8	-1.3	-0.7
Medication: Aspirin	1.1	1.4	3.8	0.1	-1.9	-1.2	-1.4	0.2
Risk taking	1.1	1.6	2.6	0.9	-0.9	-1.2	-1.5	-1.6
Pack years of smoking	1.1	1.5	2.7	-0.2	-1.5	-1.6	-1.5	0.6
Verbal and Numeric Reasoning (VNR)	1.0	2.5	5.1	1.1	1.3	2.1	2.2	-0.6
Neuroticism	1.0	2.5	6.3	2.5	-1.3	-1.4	-1.6	-0.5
Average weekly spirits intake	1.0	1.2	2.9	0.4	0.2	-1.7	-1.7	0.3
Qualifications: None of the above	1.0	2.2	4.8	-2.0	-2.2	-0.6	-1.0	-0.8
Illnesses of siblings	1.0	1.4	4.3	-1.1	2.1	0.4	1.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.0	-0.6	1.4	1.1	1.4	0.8
Neck or shoulder pain in last month	1.0	1.4	3.4	1.9	-1.0	-0.1	0.0	1.6
Breast cancer (self-reported)	1.0	1.1	3.1	1.8	-0.6	-1.0	-0.9	0.5
Smoking status: Current	1.0	1.7	3.0	1.7	-1.3	-1.3	-1.2	-0.7
Alcohol drinker status: Never	1.0	1.2	2.0	-0.5	0.6	1.3	1.4	1.4
Supplements: Calcium	1.0	1.1	2.7	0.2	-1.2	-1.6	-0.9	0.4
Age at First Birth	0.9	1.4	3.5	-0.7	0.3	1.9	1.5	-0.6
Mean Putamen Volume	0.9	1.0	2.8	-0.1	-0.0	1.5	1.7	0.1
Smoking Status	0.9	2.1	3.1	1.8	-1.4	-1.6	-1.7	0.3
Townsend deprivation index at recruitment	0.9	1.2	2.2	-1.1	-1.5	-0.7	-0.9	-1.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.1	-0.4	-1.5	-0.7	-1.0	1.3
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.3	1.0	1.8	1.6	1.7	-0.1
Birth weight of first child	0.9	1.6	3.9	-1.2	2.0	1.1	1.2	-0.4
Wheeze or whistling in the chest in last year	0.9	1.6	2.2	1.1	-1.5	-1.3	-1.4	1.1
Number of children fathered	0.9	1.0	2.3	0.2	-0.3	-0.9	-1.4	1.5
Medication: Aspirin	0.9	1.2	2.7	0.0	-1.6	-1.2	-1.3	0.2
Osteoporosis (self-reported)	0.9	1.2	3.1	-1.8	1.1	0.5	1.1	-0.2
Guilty feelings	0.9	1.4	5.3	2.3	-0.8	-0.4	-0.5	-0.9
Hearing aid user	0.9	1.0	2.1	0.3	1.1	1.3	1.5	0.4
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.8	0.3	1.2	1.2	1.7	-0.7
High cholesterol (Self-reported)	0.9	1.5	2.6	0.5	-1.4	-1.4	-1.6	-0.9
Ever smoked	0.9	1.6	4.0	2.0	-0.6	-1.1	-1.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.7	1.1	0.6	0.8	1.6	0.9
Depressed Affect (Nagel 2018)	0.8	1.7	3.7	0.7	-1.2	-1.9	-1.6	0.4
Hypothyroidism (self reported)	0.8	1.9	3.5	-0.1	1.0	1.9	1.3	-1.8
Medication for hormone replacement therapy	0.8	0.9	2.8	-1.1	0.7	0.1	0.1	-1.7
Number of incorrect matches in round	0.8	1.3	3.1	-1.8	0.7	1.0	1.2	0.5
Alcohol usually taken with meals	0.8	1.3	2.2	-1.5	1.4	1.0	0.8	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.2	2.1	-0.1	0.1	0.4	1.2
Father’s age at death	0.8	1.1	3.7	-1.9	1.3	-0.1	0.2	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	4.1	0.6	-2.0	-0.5	-0.2	0.1
Depression (self-reported)	0.8	1.0	1.8	-0.1	-1.1	-1.3	-1.1	-0.8
Shortness of breath walking on level ground	0.8	0.9	1.5	0.6	-1.2	-1.1	-0.7	1.0
Overall health rating	0.8	1.8	3.3	1.8	-1.5	-1.2	-1.0	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.4	1.0	-0.9	0.2	0.2	1.6
Ever taken oral contraceptive pill	0.8	0.9	3.3	0.7	0.8	-0.1	-0.4	1.8
Pain experienced in last month	0.8	1.3	3.9	-1.4	0.6	0.2	-0.1	-2.0
Body Mass Index (BMI) (2010)	0.7	1.0	2.0	-0.1	0.1	-1.2	-1.2	-1.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	-1.2	-1.1	-1.0	-0.4	-0.2
Allergy or Eczema	0.7	1.8	3.5	0.9	1.3	1.6	1.9	0.5
Ever had hysterectomy (womb removed)	0.7	0.8	1.7	0.2	-0.3	-0.8	-1.3	-1.2
Vitamin and mineral supplements	0.7	1.0	1.3	0.9	-1.0	-0.9	-1.1	-0.9
Supplements: Zinc	0.7	0.7	3.4	-0.3	0.0	-0.2	0.5	1.8
Pack years adult smoking proportion	0.7	1.0	1.8	0.2	-1.3	-1.3	-1.2	0.3
Neuroticism score	0.7	1.4	5.7	2.4	-0.6	-0.6	-0.7	0.2
Medication: Paracetamol	0.7	1.2	3.1	0.3	0.7	1.1	1.1	1.8
Mouth/teeth dental problems: Loose teeth	0.7	0.9	4.1	2.0	-0.3	0.2	0.2	-0.1
Knee pain experienced in last month	0.7	1.1	4.0	2.0	-1.1	-0.1	0.6	-0.4
Average weekly red wine intake	0.7	1.0	2.1	1.0	1.5	-0.3	-0.1	-1.4
Eye problems/disorders: Cataract	0.7	0.8	2.2	0.2	-1.5	-0.7	-0.7	0.8
Medication: Paracetamol	0.7	1.0	4.4	0.3	-0.4	0.5	0.5	2.1
Medication: Lisinopril	0.7	0.8	1.3	-0.1	-1.1	-1.1	-0.9	1.0
Leg fat percentage (left)	0.7	2.6	4.2	1.7	-1.4	-2.0	-2.0	-0.0
Average weekly beer plus cider intake	0.7	1.0	1.9	-1.4	0.6	0.6	0.9	1.3
Fractured/broken bones in last 5 years	0.7	0.9	1.7	0.1	-0.9	-1.3	-1.1	0.8
Myopia	0.7	1.1	2.6	-0.0	1.1	1.6	1.0	-0.7
Depression (Nagel 2018)	0.6	0.9	2.9	1.7	-1.1	0.2	0.2	0.0
Neuroticism (Nagel 2018)	0.6	1.3	4.5	2.1	-0.7	-0.9	-0.8	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	2.3	-0.7	0.5	0.6	0.6	-1.5
Alzheimer’s Disease (in father)	0.6	0.6	2.6	1.6	-0.2	-0.5	-0.3	-0.2
Ulcerative Colitis (UC)	0.6	1.1	3.1	-1.0	0.6	0.4	0.9	-1.8
Major Depression (MDD)	0.6	0.7	2.7	1.7	-0.6	-0.2	-0.0	0.5
LDL Cholesterol	0.6	1.0	2.3	0.3	0.4	1.5	0.8	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.6	1.6	-0.9	0.3	0.5	0.5
Taking other prescription medications	0.6	0.9	2.0	0.8	-0.6	1.1	1.4	0.1
High blood pressure (mother)	0.6	0.8	2.7	1.7	0.3	-0.3	-1.0	0.5
Past tobacco smoking	0.6	1.0	2.4	-1.5	0.3	0.8	1.5	-0.1
Nervous feelings	0.6	1.1	3.3	0.2	0.6	1.2	1.8	0.3
Had menopause	0.6	0.8	1.7	0.4	-1.3	-0.9	-0.8	-0.8
Mouth/teeth dental problems	0.6	0.9	2.3	-0.9	0.4	-0.9	-0.6	1.5
Allergy	0.6	1.4	1.7	-1.2	-0.8	-1.2	-1.2	-1.3
Pain all over the body in last month	0.6	0.7	2.0	0.5	1.4	0.7	0.5	0.5
Fluid intelligence score	0.6	1.2	2.7	1.6	0.8	0.9	1.3	-0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.0	-0.4	0.6	1.3	0.7	-1.7
Leg fat percentage (right)	0.6	2.3	5.0	2.2	-1.2	-1.6	-1.6	-0.3
Health satisfaction	0.6	0.8	1.6	1.3	-0.6	-0.4	-0.2	1.2
Medication: Seretide 50 evohaler	0.6	0.7	1.5	-0.3	0.4	0.8	1.2	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.6	-0.6	1.3	-0.0	-0.3	1.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.6	1.0	-0.8	0.6	0.4	1.3
Medication: Atorvastatin	0.6	0.8	2.9	0.9	0.3	0.2	-0.1	-1.7
Ever depressed for a whole week	0.6	0.8	1.4	0.7	-0.6	-1.2	-1.2	-0.3
Worry (Nagel 2018)	0.5	1.0	3.9	2.0	0.4	0.8	0.6	0.2
Irritable Bowel Disease (IBD)	0.5	1.2	2.6	-0.8	-0.9	-1.6	-1.2	-0.8
Rheumatoid Arthritis	0.5	0.7	1.8	-1.2	-0.1	-0.0	-0.3	-1.3
Blood Eosinophil Count	0.5	3.5	6.0	1.6	-2.4	-1.1	-1.5	-2.3
Relative age of first facial hair	0.5	1.1	2.6	1.1	-0.3	0.5	1.1	1.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.9	1.7	-0.5	-0.4	-0.4	-0.2
Leg fat-free mass (left)	0.5	2.8	7.3	0.8	2.7	1.2	1.2	1.7
Age when periods started (menarche)	0.5	1.1	2.6	0.8	0.9	1.2	1.6	-0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	0.9	-1.1	0.0	-0.9	-0.4
Leg predicted mass (left)	0.5	2.7	7.3	0.8	2.7	1.1	1.2	1.8
Trunk fat-free mass	0.5	2.7	7.1	1.8	2.7	1.1	1.2	1.0
Worrier / anxious feelings	0.5	1.0	4.0	2.0	-0.1	-0.6	-0.8	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.0	-0.1	1.7	0.9	1.3	-0.2
Medication: Cholesterol lowering	0.5	0.8	1.1	0.3	-1.0	-1.0	-1.0	-1.0
Prospective memory result	0.5	0.6	2.2	-1.5	0.1	-0.6	-0.7	0.0
Trunk predicted mass	0.5	2.6	6.9	1.7	2.6	1.0	1.1	1.1
Tense / ‘highly strung’	0.5	0.8	4.0	2.0	-0.2	0.2	-0.3	0.1
High blood pressure (siblings)	0.5	0.7	1.7	1.3	-1.1	0.7	0.3	-0.4
Exposure to tobacco smoke outside home	0.5	0.7	2.6	1.6	-0.1	0.2	0.5	-0.8
Arm predicted mass (right)	0.5	2.5	6.1	2.5	2.0	0.5	0.5	1.3
Suffer from ‘nerves’	0.5	0.9	2.1	1.5	-0.4	0.2	0.7	1.2
Supplements: Vitamin C	0.5	0.6	1.5	-0.2	1.2	0.9	0.9	0.2
Ever had bowel cancer screening	0.5	0.6	1.1	0.3	-0.8	0.7	0.8	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.8	-0.4	-0.4	-0.6	-1.1	-1.4
Asthma (self-reported)	0.5	1.0	3.2	0.2	-1.0	-0.5	-0.6	1.8
Financial situation satisfaction	0.5	0.6	1.8	0.4	-0.2	-0.9	-0.7	1.3
Basal metabolic rate	0.5	2.5	6.4	1.3	2.5	1.0	1.1	1.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.1	-0.9	0.4	0.1	0.3	1.4
Diastolic blood pressure, automated reading	0.5	1.5	4.1	0.8	-0.4	-2.0	-1.7	0.0
Alcohol drinker status: Previous	0.5	0.6	1.1	-0.5	-0.9	-1.0	-1.0	0.1
Bipolar Disorder or Schizophrenia	0.4	1.0	1.5	1.1	-1.2	-0.9	-1.1	-0.5
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	0.4	0.5	-0.4	-1.1	-0.8
Ovarian Cancer	0.4	0.5	1.6	-1.3	-0.3	0.2	0.6	0.6
HbA1C	0.4	0.4	0.7	-0.2	0.8	0.9	0.8	0.2
Heel T-Score	0.4	3.0	9.1	-1.0	-1.3	-1.5	-1.1	-3.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	1.0	-0.2	-0.5	-0.8	-0.2
Diabetes (father)	0.4	0.5	1.4	-1.2	-0.2	0.4	0.7	-0.6
Fed-up feelings	0.4	0.8	1.4	0.4	-0.3	-0.8	-1.2	1.2
Medication: Levothyroxine sodium	0.4	0.6	1.5	0.3	0.1	1.2	1.0	-0.7
Sitting height	0.4	2.8	6.2	-1.1	2.1	0.6	1.3	2.5
Trunk fat mass	0.4	1.7	3.7	-0.1	1.7	0.9	1.1	1.9
Waist circumference	0.4	1.3	4.1	2.0	0.0	-0.9	-0.8	1.0
Diabetes (self-reported)	0.4	0.6	0.9	0.8	-0.8	-0.9	-1.0	-0.0
Noisy workplace	0.4	0.5	1.3	0.8	-1.1	-0.5	-0.7	-0.1
Mouth/teeth dental problems: Dentures	0.4	0.6	1.4	0.1	-1.2	0.9	0.5	0.8
Asthma	0.4	0.7	2.9	-0.2	-0.7	-0.1	-0.2	1.7
Hair/balding pattern: Pattern 4	0.4	1.1	2.3	0.4	-0.6	-1.0	-1.2	-1.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	1.1	-0.3	-0.7	-0.8	0.2
Headache pain in last month	0.4	0.7	2.3	-0.3	1.5	0.3	0.5	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.2	-0.8	0.8	0.7	1.1	-0.2
Birth weight	0.4	1.0	1.5	0.4	1.2	1.0	1.2	0.8
Arm fat-free mass (right)	0.4	2.2	5.8	2.4	1.9	0.3	0.3	1.2
Number of full brothers	0.4	0.5	0.9	0.9	-0.5	0.5	-0.0	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	-0.3	-0.6	-0.7	-0.5	1.1
Medication: Omeprazole	0.4	0.5	1.1	0.1	0.7	1.0	1.0	0.2
Number of full sisters	0.4	0.5	1.4	0.5	0.2	0.5	0.7	-1.2
Whole body fat-free mass	0.4	2.5	7.2	1.3	2.7	1.0	1.0	1.4
Leg fat-free mass (right)	0.4	2.3	5.8	0.5	2.4	0.7	0.8	2.0
Mood swings	0.4	0.6	1.0	1.0	0.8	-0.9	-0.7	-0.6
Diabetes diagnosed by doctor	0.4	0.6	1.6	1.2	-0.4	-0.8	-0.8	-0.5
Whole body water mass	0.4	2.5	6.8	1.5	2.6	0.9	1.0	1.3
Leg predicted mass (right)	0.4	2.2	5.8	0.5	2.4	0.7	0.7	2.0
Number of operations (self-reported)	0.4	0.5	1.2	1.1	0.6	0.6	0.7	-0.5
Irritability	0.4	0.6	2.5	1.6	-0.5	0.1	-0.6	-0.3
Commuting to job workplace: Cycle	0.4	0.4	1.1	0.2	1.0	0.2	0.4	1.0
Triglycerides	0.3	0.4	0.8	0.1	0.6	0.6	0.7	-0.9
Respiratory disease	0.3	0.7	3.0	0.5	-0.4	-0.0	0.1	1.7
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	0.5	-1.0	-0.4	-0.4	0.7
Severe depression (siblings)	0.3	0.4	0.6	-0.7	0.7	0.5	0.5	0.8
Trunk fat percentage	0.3	1.3	3.3	-0.7	1.1	0.8	0.9	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	1.2	-0.6	-0.5	-1.2	0.3
Qualifications: CSEs or equivalent	0.3	0.4	1.1	1.1	-0.6	-0.3	0.0	0.4
Serious illness, injury or assault to yourself	0.3	0.4	0.7	0.8	0.2	-0.7	-0.7	0.1
Medication: Atenolol	0.3	0.4	1.4	0.2	-0.6	-0.1	0.1	-1.2
Weight	0.3	1.4	3.0	1.1	1.7	0.4	0.5	1.6
Alcohol intake versus 10 years previously	0.3	0.4	0.8	0.7	-0.4	0.9	0.3	0.7
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.4	0.8	0.9	0.5	0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.7	0.4	1.3	0.5	0.7	0.5
Illnesses of siblings: Diabetes	0.3	0.4	0.5	0.7	-0.7	-0.2	-0.6	0.7
Commuting to job workplace: Walk	0.3	0.4	0.8	-0.1	-0.7	-0.9	-0.6	-0.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.2	0.8	-0.9	-0.1	-0.3	1.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	0.6	0.7	0.3	0.6	0.5
Medication: Bendroflumethiazide	0.3	0.5	1.3	0.0	1.1	0.5	0.3	-1.0
Arm fat-free mass (left)	0.3	1.6	4.0	2.0	1.6	0.3	0.3	1.0
Age started oral contraceptive pill	0.3	0.3	0.8	-0.9	0.6	0.5	0.4	0.4
Unable to work because of sickness or disability	0.3	0.4	1.1	1.0	-0.7	0.3	0.1	-0.7
Arm predicted mass (left)	0.3	1.5	3.6	1.9	1.6	0.2	0.1	1.1
HDL Cholesterol	0.2	0.3	1.2	0.4	-0.3	0.4	0.2	1.1
Waist Hip Ratio (WHR)	0.2	1.0	2.4	0.3	1.6	0.8	0.8	1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.7	0.8	0.7	-0.2	-0.3	-0.5
Tanning	0.2	2.2	2.8	1.7	1.6	1.4	1.5	-1.2
Medication: Co-codamol	0.2	0.2	0.4	-0.4	-0.2	-0.5	-0.5	-0.7
Medication: Metformin	0.2	0.3	0.5	0.6	-0.5	-0.6	-0.7	-0.0
Diabetes (mother)	0.2	0.3	0.6	0.7	-0.4	0.3	0.8	0.4
Relative age voice broke	0.2	0.4	1.0	1.0	-0.3	-0.5	0.4	0.5
Multivitamins +/- minerals	0.2	0.3	0.5	0.7	0.4	0.3	0.5	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	2.3	1.5	0.0	0.4	-0.1	0.6
Heart attack	0.2	0.3	0.7	0.8	-0.2	-0.1	-0.5	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	-0.1	-0.5	-0.9	-0.4	0.6
Gout (self-reported)	0.2	0.2	1.0	-0.3	0.1	-0.2	0.1	-1.0
Medication: Amlodipine	0.2	0.3	0.6	0.4	-0.3	-0.6	-0.7	-0.8
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.8	-0.0	-0.8	-0.3	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.3	-0.2	0.3	-0.5	-0.4	-1.1
Medication: Blood pressure	0.2	0.3	0.4	0.4	-0.5	-0.4	-0.6	0.7
Mean time to correctly identify matches	0.2	0.4	0.8	0.0	-0.5	-0.5	-0.7	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	0.5	-0.4	-0.5	-0.4	0.5
Whole body fat mass	0.2	0.9	2.1	0.6	1.3	0.5	0.5	1.5
Leg fat mass (right)	0.2	0.9	3.6	1.9	0.4	-0.6	-0.6	0.5
Had major operations	0.2	0.3	0.6	-0.5	-0.4	-0.6	-0.8	0.3
Leg pain on walking	0.2	0.2	0.6	0.3	-0.6	-0.3	-0.3	0.7
Smoking status: Previous	0.2	0.4	0.9	0.6	0.1	-0.2	-0.9	0.7
Back pain experienced in last month	0.2	0.3	0.9	0.5	-0.6	-0.4	-0.0	0.9
Medication: Gliclazide	0.2	0.2	0.6	0.0	-0.8	-0.4	-0.3	-0.5
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	0.3	0.2	-0.8	-0.5	0.5
Mother’s age at death	0.2	0.3	0.7	-0.7	0.3	-0.8	-0.5	-0.0
Basal cell carcinoma (self-reported)	0.2	0.3	0.9	0.5	-0.0	0.4	0.9	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	0.6	-0.3	-0.1	-0.4	-0.8
Leg fat mass (left)	0.2	0.9	2.3	1.5	0.3	-1.0	-0.9	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	0.7	0.5	0.3	0.7	0.3
Schizophrenia (2018)	0.1	0.2	0.3	0.1	-0.6	0.2	-0.3	-0.6
Reaction Time	0.1	0.2	0.5	0.7	0.5	-0.0	-0.3	-0.2
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.2	-0.6	-0.3	0.2	0.3
Schizophrenia (2014)	0.1	0.2	0.7	0.4	-0.8	-0.0	-0.4	-0.2
Number of treatments/medications taken	0.1	0.2	0.8	0.0	0.1	0.3	0.3	0.9
Had other major operations	0.1	0.2	0.6	-0.0	-0.0	0.4	0.8	0.0
Medication: Ramipril	0.1	0.1	0.3	0.5	-0.1	-0.2	-0.3	-0.4
Arm fat percentage (right)	0.1	0.4	0.7	0.8	-0.5	-0.8	-0.6	0.6
Hip circumference	0.1	0.6	2.1	0.5	0.6	-0.2	0.1	1.5
Arm fat mass (right)	0.1	0.6	1.7	1.3	0.4	-0.2	-0.2	0.9
Loud music exposure frequency	0.1	0.1	0.5	0.7	0.2	-0.2	-0.2	-0.1
Body fat percentage	0.1	0.3	1.5	0.4	0.3	-0.1	0.0	1.2
Pulse wave peak to peak time	0.1	0.2	0.3	-0.5	-0.1	-0.5	-0.1	-0.4
Qualifications: College or University degree	0.1	0.4	1.4	0.2	1.2	0.3	0.6	0.1
Alcohol intake frequency.	0.1	0.3	0.4	-0.7	-0.4	0.5	0.6	-0.3
Arm fat percentage (left)	0.1	0.4	1.0	0.7	-0.1	-0.6	-0.4	1.0
Loneliness, isolation	0.1	0.1	0.2	0.1	0.2	0.3	0.4	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.6	0.5	0.1	-0.1	0.2	-0.8
Arm fat mass (left)	0.1	0.6	1.3	1.0	0.5	-0.3	-0.3	1.1
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.1	-0.4	-0.3	-0.4	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.4	-0.1	0.1	0.4	0.4
Blood Red Count	0.0	0.1	0.1	0.2	-0.3	0.3	-0.0	0.0
Hair Pigment	0.0	0.1	0.3	-0.1	-0.5	-0.3	0.5	0.2
Age at first live birth	0.0	0.1	0.2	0.2	-0.2	0.4	0.1	0.2
Age at last live birth	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.4	-0.1

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