Hub : Genes

FGF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1150	0.0320	5.1e-05	0.078	0.043	0.067	0.066	0.071	9.9e-10	5.2e-06	1.3e-08	1.6e-08	4.8e-09
2	GTEx	Nerve Tibial	0.4300	0.0560	6.5e-13	0.345	NA	0.323	NA	0.345	2.9e-25	NA	2.0e-23	NA	3.0e-25
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1940	0.0620	1.0e-03	0.018	NA	0.005	NA	0.010	3.3e-02	NA	1.6e-01	NA	8.3e-02
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0624	0.0303	7.8e-03	0.003	0.013	0.016	NA	0.009	1.2e-01	1.1e-02	5.2e-03	NA	2.7e-02
5	TCGA	Skin Cutaneous Melanoma	0.2130	0.0860	8.4e-03	0.065	0.031	0.006	NA	0.029	8.1e-03	5.1e-02	2.1e-01	NA	5.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.6	2.5	3.8	1.8	-2.0	-1.3	1.0	-1.6
Bipolar Disorder or Schizophrenia	0.7	1.7	3.6	1.8	-1.9	-1.1	-0.3	-0.6
Depressed Affect (Nagel 2018)	0.6	1.4	3.6	1.1	-1.2	1.9	0.1	-0.8
Depression (Nagel 2018)	0.7	1.1	1.8	1.1	-1.2	-1.0	0.1	-1.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.7	-0.8	0.8	-0.5	0.4	0.2
Neuroticism (Nagel 2018)	0.4	1.0	2.0	0.8	-0.8	1.4	-0.1	-1.4
Schizophrenia (2018)	0.2	0.4	0.7	0.9	-0.9	-0.4	-0.2	0.3
Schizophrenia vs Biploar Disorder	0.6	0.8	2.7	0.5	-0.3	-1.7	0.0	0.9
Worry (Nagel 2018)	0.3	0.7	1.6	-0.5	0.6	1.2	-1.0	-0.4
Alzheimer’s Disease (in mother)	0.8	1.0	3.2	-0.8	0.6	-1.8	-0.8	-0.0
Alzheimer’s Disease (in father)	1.2	1.3	2.2	-1.4	1.3	0.6	0.1	1.5
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	-1.1	0.9	-1.5	0.5	0.2
Crohns Disease (2017)	0.3	0.7	1.8	0.4	-0.5	-1.3	0.8	0.8
Irritable Bowel Disease (IBD)	0.5	1.3	3.8	0.6	-0.8	-2.0	0.1	1.2
Ulcerative Colitis (UC)	0.8	1.6	4.5	0.8	-1.0	-2.1	-1.0	0.8
Major Depression (MDD)	0.7	0.9	1.6	1.1	-1.3	0.5	0.9	-0.8
Reaction Time	1.9	3.6	7.8	1.9	-2.5	0.5	0.1	-2.8
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	-0.6	0.8	-0.6	0.3	-0.2
Breast Cancer	0.9	2.2	4.6	1.1	-0.9	-1.8	2.1	-1.0
Ovarian Cancer	0.3	0.3	0.7	-0.3	0.5	0.0	0.8	-0.8
Prostate Cancer	0.2	0.3	0.9	0.2	0.0	0.5	0.4	-0.9
Age at First Birth	0.5	0.8	1.8	-0.8	0.8	-0.9	-0.0	1.3
Bipolar Disorder (2011)	1.7	1.6	3.5	1.8	-1.9	-1.3	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	5.2	-0.3	0.2	-2.3	0.9	-0.3
Coronary Artery Disease (CAD)	0.9	1.1	2.9	1.6	-1.7	-0.1	0.0	0.0
Crohns Disease (2012)	0.1	0.2	0.5	0.1	0.1	-0.7	0.0	0.7
Mean Putamen Volume	0.3	0.3	1.2	0.2	-0.1	-1.1	0.3	-0.4
Fasting Glucose	1.0	1.2	3.7	-1.1	0.8	1.9	-0.4	0.3
HbA1C	1.5	1.7	4.3	-0.7	1.0	-2.1	-1.0	1.2
HDL Cholesterol	0.3	0.5	1.2	0.9	-1.1	-0.4	0.5	-0.2
LDL Cholesterol	0.4	0.6	2.0	0.6	-0.4	1.4	0.4	-0.7
Lupus	0.6	1.0	3.5	0.8	-0.7	-1.9	-0.4	-0.4
Neuroticism (2016)	0.4	0.5	1.5	-0.1	0.5	1.2	-0.8	-0.5
Primary Biliary Cirrhosis	0.3	0.4	0.9	0.3	-0.4	0.9	0.0	-0.9
Rheumatoid Arthritis	0.1	0.1	0.4	0.3	-0.6	0.1	-0.1	0.4
Schizophrenia (2014)	0.5	1.2	3.1	1.8	-1.4	-0.3	-0.8	-0.3
Triglycerides	0.2	0.3	1.0	-0.4	0.4	-1.0	0.0	-0.3
Type 2 Diabetes (T2D) (2012)	3.0	3.5	5.8	-2.4	2.4	-0.8	0.0	2.3
Ulcerative Colitis	0.9	1.3	3.6	0.9	-0.7	-1.9	-1.2	-0.0
Blood Eosinophil Count	0.1	0.9	1.8	0.9	-1.1	1.3	0.1	-0.9
Blood Platelet Count	0.4	4.7	7.2	-2.7	2.5	-2.4	-1.0	1.9
Blood Red Count	0.4	3.7	7.5	-1.6	1.4	1.5	-2.1	2.7
Blood White Count	0.4	3.0	4.8	2.2	-2.2	-0.8	0.1	-2.2
Heel T-Score	2.0	16.1	31.5	5.6	-5.5	-0.0	2.5	-3.6
BMI	0.2	1.3	4.9	-0.3	-0.0	-2.2	1.2	-0.3
Height	0.7	14.2	28.8	5.4	-5.2	0.4	0.9	-3.8
Waist Hip Ratio (WHR)	1.9	8.4	16.6	2.6	-2.8	0.2	-4.1	-3.2
Systolic Blood Pressure	0.5	2.7	9.6	-1.3	1.3	3.1	0.5	-0.1
Smoking Status	0.1	0.2	0.6	-0.2	0.2	0.7	-0.3	-0.4
Allergy or Eczema	0.1	0.4	0.9	0.9	-0.6	0.0	-0.4	-0.6
Cardiovascular Disease	0.2	0.8	2.0	-0.8	0.7	0.7	-0.5	-1.4
Hypothyroidism (self reported)	0.2	0.4	1.0	-1.0	0.9	-0.1	-0.4	-0.1
Respiratory disease	0.1	0.2	0.5	0.0	0.4	0.7	-0.0	0.4
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.0	1.3	-1.4	-2.0	0.3	-1.5
Lung FEV1/FVC ratio	0.1	0.6	2.5	-0.0	0.6	-0.4	1.6	-0.0
Lung FVC	0.3	1.3	3.2	1.8	-1.6	0.4	0.1	0.7
Neuroticism	0.1	0.3	1.3	0.0	-0.1	1.1	-0.6	-0.2
Chronotype (morning person)	0.5	1.1	4.2	-0.1	-0.1	-1.1	-2.0	-0.3
Hair Pigment	0.1	1.7	3.6	0.7	-0.5	-0.8	-1.9	-1.9
Tanning	0.1	0.7	2.0	-0.6	0.6	1.4	-0.1	0.8
Hand grip strength (left)	0.7	1.9	3.4	1.5	-1.5	-1.2	1.8	-0.4
Number of treatments/medications taken	2.7	4.8	11.5	2.5	-2.4	-0.2	0.1	-3.4
Average weekly spirits intake	0.4	0.5	1.7	0.4	-0.5	-0.1	-1.3	-0.5
Sensitivity / hurt feelings	0.1	0.2	0.7	0.2	-0.4	0.1	-0.3	-0.8
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.2	1.3	-1.5	-1.0	-0.6	-1.2
Hearing difficulty/problems: Yes	0.1	0.1	0.4	-0.1	0.4	0.2	-0.0	0.6
Relative age of first facial hair	0.9	1.9	2.8	-1.4	1.5	-1.7	-0.9	1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.0	0.9	-0.3	1.0	-1.0	-0.8
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.5	0.9	-1.1	0.2	-0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	-0.1	0.1	-0.6	0.1	0.8
Systolic blood pressure, automated reading	0.3	0.8	1.5	-0.7	0.5	1.2	-0.9	0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.8	0.6	-0.4	0.7	0.9	-0.9
Angina	0.1	0.1	0.2	-0.4	0.3	0.3	-0.3	0.3
Medication for hormone replacement therapy	0.2	0.2	0.8	-0.1	0.5	0.1	0.3	-0.9
Vitamin and mineral supplements	0.4	0.6	1.4	0.6	-0.6	1.2	-0.1	-0.9
Supplements: Zinc	0.5	0.5	1.4	-0.1	0.5	0.9	-1.2	-0.1
Medication: Co-codamol	0.2	0.3	0.8	-0.9	0.6	0.2	0.4	-0.1
Medication: Metformin	0.9	1.2	2.2	1.0	-1.0	-1.2	0.7	-1.5
Diabetes (father)	0.6	0.7	1.3	-1.1	1.0	0.9	-0.4	0.6
Diabetes (mother)	0.7	0.9	2.0	0.8	-0.9	-0.9	-1.4	-0.3
Severe depression (siblings)	0.3	0.3	0.9	-0.3	0.2	-1.0	-0.1	0.6
Pack years adult smoking proportion	0.2	0.3	0.7	0.5	-0.7	-0.8	-0.2	-0.3
Impedance of leg (right)	0.2	0.9	2.0	-0.3	0.5	-1.4	-1.4	0.7
Leg fat-free mass (left)	0.3	1.4	4.2	0.9	-1.1	-0.6	2.0	-0.7
Trunk fat percentage	0.6	2.5	8.2	-1.2	0.9	-2.9	-0.5	1.4
Hand grip strength (right)	0.6	1.6	2.7	1.2	-1.1	-1.5	1.6	-0.3
Townsend deprivation index at recruitment	1.9	2.7	6.7	2.0	-2.6	0.1	0.3	-1.6
Current tobacco smoking	0.3	0.4	1.7	0.4	-0.4	0.2	-0.3	-1.3
Average weekly fortified wine intake	0.4	0.4	1.1	-0.6	0.5	0.7	-0.2	1.1
Maternal smoking around birth	1.0	1.5	3.6	-0.6	0.3	-1.0	-1.9	1.6
Fed-up feelings	1.2	2.2	7.9	1.1	-1.2	2.8	0.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.7	0.7	-0.9	-0.7	-0.4	-1.3
Relative age voice broke	1.0	1.6	3.5	-0.9	1.1	-1.4	0.8	1.9
Taking other prescription medications	0.4	0.6	2.2	0.5	-0.4	0.3	-0.3	-1.5
Age when periods started (menarche)	0.1	0.2	0.9	-0.1	-0.1	0.5	0.9	-0.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	-0.3	0.4	-0.4	-0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	4.9	2.2	-2.1	0.4	0.8	-1.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.5	-0.5	-0.2	0.6	-1.1
Qualifications: CSEs or equivalent	2.6	3.4	4.8	1.6	-2.0	-0.9	2.2	-2.1
Serious illness, injury or assault to yourself	2.4	3.0	5.5	2.2	-2.4	-0.3	-0.2	-2.1
High blood pressure	0.4	1.1	2.5	-0.9	0.5	1.6	-1.4	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.3	-0.1	-0.7	0.4	-0.6
Multivitamins +/- minerals	0.5	0.6	1.3	-0.2	0.3	-0.9	1.1	0.8
Stomach or abdominal pain in last month	0.5	0.6	1.8	0.9	-0.7	0.2	0.0	-1.3
Supplements: Glucosamine	0.2	0.3	1.0	0.3	-0.1	0.5	1.0	0.3
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.3	1.4	-1.5	0.0	0.4	-1.3
Medication: Atenolol	0.2	0.2	0.4	-0.3	0.7	-0.3	0.4	-0.6
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.7	0.4	-0.6	-0.3	-0.7
Sitting height	0.1	0.8	1.7	1.1	-1.3	-0.7	1.0	0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	-0.8	0.7	-0.1	-0.1	0.2
High blood pressure (mother)	0.2	0.3	1.4	0.0	0.0	1.2	0.3	-0.2
Body mass index (BMI)	0.3	1.3	6.0	-0.2	-0.2	-2.5	0.5	0.1
Impedance of leg (left)	0.1	0.7	1.7	-0.2	0.4	-1.2	-1.3	0.5
Leg predicted mass (left)	0.3	1.4	4.5	0.8	-1.1	-0.7	2.1	-0.6
Trunk fat mass	0.4	1.7	7.8	-0.5	0.2	-2.8	0.1	0.8
Waist circumference	0.5	1.7	4.9	0.9	-1.4	-2.2	-0.7	-0.8
Number of incorrect matches in round	1.2	2.0	3.1	1.6	-1.8	1.6	0.5	-1.2
Past tobacco smoking	0.4	0.8	1.3	-0.5	0.7	-1.0	-1.0	1.1
Alcohol usually taken with meals	0.4	0.7	1.0	-0.9	0.7	0.9	1.0	0.5
Nervous feelings	0.1	0.1	0.3	-0.4	0.2	0.5	-0.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	-0.1	0.1	-0.6	-0.2	-0.4
Hearing difficulty/problems with background noise	0.3	0.5	1.0	-0.5	0.5	0.5	-1.0	-0.7
Hair/balding pattern: Pattern 2	0.9	1.1	2.5	-0.5	0.4	1.6	-0.5	1.5
Had menopause	1.3	1.6	3.0	-1.0	0.9	1.0	-1.5	1.7
Had other major operations	0.6	0.8	2.4	0.4	-0.1	-1.6	1.0	-0.5
Forced vital capacity (FVC)	0.6	2.3	4.2	2.0	-2.0	0.9	1.6	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	3.3	7.6	14.1	3.8	-3.7	0.3	1.7	-2.8
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	6.3	-0.1	0.2	2.5	-0.4	-0.4
Qualifications: None of the above	0.4	0.8	1.8	0.7	-1.4	-0.6	-0.9	0.9
Financial difficulties in last 2 years	0.9	1.2	3.5	0.0	0.0	-0.5	-1.9	-1.4
Mouth/teeth dental problems	0.9	1.4	4.6	0.0	0.3	-2.1	0.5	-1.5
Heart attack	1.0	1.3	3.1	1.1	-0.9	1.8	-1.0	-0.5
Allergy	0.2	0.4	0.8	0.6	-0.8	0.9	0.4	-0.5
Pain all over the body in last month	0.5	0.6	2.0	0.3	0.2	1.4	0.1	-0.8
Diabetes (self-reported)	1.2	1.9	4.5	0.8	-1.0	-2.1	1.0	-1.5
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	5.2	0.9	-0.9	-1.2	-0.6	-2.3
Medication: Ramipril	0.9	1.2	3.2	-0.9	0.8	1.8	-1.0	0.5
Medication: Simvastatin	0.5	0.7	1.3	0.9	-1.2	-0.7	-0.4	-0.8
Fluid intelligence score	0.1	0.1	0.2	-0.3	0.4	0.1	-0.4	0.4
Illnesses of siblings	0.2	0.3	0.6	0.6	-0.4	0.6	0.1	-0.8
Neuroticism score	0.4	0.9	3.0	0.4	-0.4	1.1	-1.7	0.1
Weight	0.4	2.2	6.8	0.9	-1.3	-2.6	1.3	-0.4
Impedance of arm (right)	1.5	6.8	11.0	-3.2	3.3	0.8	-1.5	3.1
Arm fat percentage (right)	0.6	2.4	6.9	-1.5	1.2	-2.6	-0.4	1.1
Trunk fat-free mass	0.8	4.4	6.9	2.4	-2.6	-0.6	2.2	-2.0
Hip circumference	0.3	1.2	3.8	-0.3	0.0	-1.9	1.4	0.3
Time employed in main current job	0.3	0.4	1.0	0.2	-0.6	-0.5	-1.0	-0.4
Alcohol intake versus 10 years previously	0.7	1.0	2.3	-1.3	0.7	-0.1	-1.5	0.8
Father’s age at death	1.7	2.2	5.5	1.4	-1.0	-0.5	2.4	-1.6
Worrier / anxious feelings	0.2	0.3	0.7	0.4	-0.2	0.8	-0.8	-0.3
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	7.8	2.0	-1.9	0.4	-0.7	-2.8
Falls in the last year	0.2	0.3	0.4	0.6	-0.4	-0.7	-0.5	-0.6
Hair/balding pattern: Pattern 3	1.6	2.4	5.0	1.7	-2.2	0.7	-0.6	-1.8
Number of live births	0.5	0.7	2.6	-0.2	0.5	-0.0	-1.6	0.7
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.3	1.7	-1.4	1.1	1.8	-0.1
Pulse rate	0.5	0.9	3.0	0.7	-0.5	-1.7	0.1	0.7
Happiness	1.2	1.5	4.2	0.4	-0.3	1.4	-2.0	1.1
Noisy workplace	1.4	1.7	3.3	1.7	-1.8	1.5	-0.3	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.9	-0.8	1.0	0.7	1.7	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.5	0.7	-0.6	-0.3	0.1
Mouth/teeth dental problems: Dentures	2.3	3.9	8.9	0.4	-0.7	2.6	-3.0	1.7
Asthma	0.4	0.8	1.5	-0.6	1.1	-0.5	-1.2	0.9
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	4.2	2.0	-1.7	-0.9	-1.3	-1.7
Medication: Cholesterol lowering	1.0	1.6	3.0	1.6	-1.7	-1.0	-0.5	-1.2
Depression (self-reported)	0.1	0.1	0.4	-0.3	0.1	-0.2	-0.6	-0.4
Medication: Lansoprazole	0.2	0.2	0.7	0.3	-0.2	0.8	-0.3	-0.3
Prospective memory result	0.8	1.0	1.9	1.4	-1.1	-0.9	0.9	-0.5
Lung cancer (father)	0.3	0.3	1.1	0.1	-0.1	1.1	0.1	0.7
Illnesses of mother	0.2	0.3	0.7	0.8	-0.4	0.1	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	5.2	1.8	-1.4	1.1	2.3	0.2
Pulse wave Arterial Stiffness index	2.1	2.5	4.6	2.2	-2.0	-1.1	0.2	-1.6
Impedance of arm (left)	1.5	7.0	10.8	-3.2	3.3	1.4	-2.0	2.9
Arm fat mass (right)	0.4	1.6	6.9	-0.6	0.2	-2.6	0.4	0.8
Trunk predicted mass	0.7	4.1	6.6	2.4	-2.6	-0.5	2.1	-1.9
Standing height	0.3	2.7	5.1	2.1	-2.3	-0.5	1.6	-0.8
Length of working week for main job	0.6	0.6	1.3	-0.5	0.7	1.0	-1.1	0.0
Exposure to tobacco smoke at home	1.5	1.6	2.6	1.5	-1.6	0.1	-1.5	-1.0
Breastfed as a baby	1.0	1.2	1.9	-1.0	1.1	0.7	-1.2	1.4
Tense / ‘highly strung’	0.3	0.5	1.6	0.7	-0.4	0.4	-0.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.6	-0.6	-0.8	-0.4	-0.9
Hair/balding pattern: Pattern 4	0.6	1.4	2.5	1.6	-1.2	0.1	0.5	-1.6
Birth weight of first child	0.4	0.7	1.8	-1.0	1.3	0.4	0.5	0.4
Peak expiratory flow (PEF)	0.3	0.8	3.5	0.0	0.1	-0.3	-0.4	1.9
Pulse wave reflection index	0.9	1.2	1.9	1.2	-1.1	0.6	-0.9	-1.4
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	1.0	-0.7	1.3	0.1	-0.9
Loud music exposure frequency	0.2	0.3	0.6	-0.4	0.4	0.3	-0.5	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.4	-0.6	1.2	0.1	1.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.9	0.3	-0.3	-1.7	0.6	-0.1
Blood clot in the leg (DVT)	0.8	1.1	2.4	1.3	-1.6	-0.9	-0.6	-0.4
Medication: Paracetamol	1.2	2.0	2.9	1.5	-1.6	0.9	-1.2	-1.7
Headache pain in last month	1.7	3.0	5.3	2.3	-1.9	-2.0	-0.7	-1.2
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.8	-1.1	1.3	0.5	0.2	1.1
Glaucoma (self-reported)	1.7	2.0	3.7	-1.8	1.9	0.7	-0.9	1.4
Gout (self-reported)	2.1	2.8	6.5	2.3	-2.5	-0.5	-0.1	-1.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.7	-1.6	1.5	-0.1	-0.1	-0.0
Medication: Amlodipine	2.7	3.8	8.8	1.7	-1.6	1.3	1.7	-3.0
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.3	-0.7	0.9	1.1	-0.4	0.4
Birth weight	0.5	1.0	2.2	-1.1	0.9	1.0	1.5	-0.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.6	0.1	-0.6	-0.3	0.3
High blood pressure (siblings)	0.3	0.4	0.9	-1.0	0.6	0.7	0.4	0.3
Forced vital capacity (FVC), Best measure	0.8	3.0	4.7	2.2	-1.9	1.3	2.2	0.0
Body fat percentage	0.6	2.4	9.7	-0.9	0.6	-3.1	-0.5	1.1
Leg fat percentage (right)	0.7	2.6	12.2	0.2	-0.6	-3.5	-0.6	0.0
Arm fat-free mass (right)	1.1	5.6	8.8	2.8	-3.0	-1.0	2.4	-2.2
Exposure to tobacco smoke outside home	0.7	0.9	2.2	1.3	-1.5	-0.3	0.8	-0.1
Comparative body size at age 10	0.1	0.4	0.8	-0.6	0.1	-0.4	0.8	0.9
Number of full brothers	0.6	0.7	1.5	1.2	-1.2	0.1	-0.8	0.4
Worry too long after embarrassment	0.8	1.4	2.4	1.5	-1.6	-1.3	-0.3	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.0	0.2	-0.4	-0.9	-1.4	-0.1
Wheeze or whistling in the chest in last year	0.5	0.9	2.7	0.8	-0.6	-0.8	0.2	-1.6
Number of children fathered	0.2	0.3	0.7	-0.2	0.2	0.6	-0.8	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.7	-1.6	1.6	0.6	0.2	0.9
Age at first live birth	0.2	0.4	1.5	-0.1	0.5	-0.4	1.2	-0.1
Pulse wave peak to peak time	1.9	2.3	4.2	-2.0	1.9	0.9	-0.2	1.7
Health satisfaction	0.2	0.3	0.8	0.2	-0.0	0.9	-0.6	0.3
Shortness of breath walking on level ground	0.9	1.0	3.3	-0.7	0.6	0.9	-1.8	0.3
Qualifications: College or University degree	0.6	1.9	5.2	-1.0	1.7	2.3	0.6	0.2
Eye problems/disorders: None of the above	0.8	0.9	1.4	-0.8	1.0	-1.2	-0.4	1.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.8	0.4	-0.3	0.5	-1.3	-0.6
Emphysema/chronic bronchitis	0.7	0.8	1.8	-1.3	1.3	0.6	-0.4	0.1
Medication for pain relief, constipation, heartburn	5.7	9.7	17.6	-4.0	3.8	-0.2	0.3	4.2
Neck or shoulder pain in last month	0.4	0.5	1.3	0.5	-0.7	-0.0	0.7	-1.1
Medication: Blood pressure	0.2	0.3	0.5	0.5	-0.6	0.7	0.0	-0.7
Angina (self-reported)	0.2	0.2	0.3	-0.5	0.4	0.5	-0.5	0.4
Migraine (self-reported)	0.7	0.9	3.3	0.3	-0.2	-1.8	-1.0	-0.2
Medication: Ibuprofen	2.0	2.4	4.5	1.9	-1.6	-0.5	-1.1	-2.1
Medication: Allopurinol	3.6	4.8	9.0	2.7	-3.0	-0.1	1.4	-2.4
Medication: Omeprazole	2.5	3.0	5.4	2.3	-2.3	-0.4	0.8	-1.8
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	-0.5	0.4	0.2	-0.1
Mean time to correctly identify matches	1.7	3.3	8.0	1.7	-2.1	1.0	-0.2	-2.8
Heart disease (mother)	2.2	2.7	6.6	1.5	-1.3	-0.7	2.6	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	0.2	-0.1	0.2	0.8	-0.1
Whole body fat mass	0.4	1.5	7.2	-0.1	-0.3	-2.7	0.2	0.5
Leg fat mass (right)	0.6	2.2	9.5	0.6	-0.9	-3.1	0.5	-0.2
Arm predicted mass (right)	0.9	4.6	7.4	2.5	-2.7	-0.8	2.1	-2.0
Pulse rate, automated reading	0.7	2.3	9.5	0.1	-0.3	-3.1	-1.4	-0.1
Alcohol intake frequency.	0.7	1.6	6.8	-0.9	0.6	0.0	-2.6	0.2
Comparative height size at age 10	0.2	1.1	2.3	-1.5	1.1	-0.4	-0.3	1.3
Number of full sisters	0.4	0.5	1.2	0.8	-1.1	-0.5	0.5	-0.5
Suffer from ‘nerves’	0.7	1.1	5.1	-0.1	0.3	2.3	-0.6	0.0
Overall health rating	0.2	0.5	1.8	0.5	-0.6	0.3	-1.4	-0.0
Chest pain or discomfort	0.5	0.7	3.2	-0.3	0.4	-0.1	-1.8	0.1
Had major operations	1.0	1.1	3.2	1.8	-1.5	-0.3	-0.1	0.1
Age at last live birth	0.2	0.3	0.6	0.6	-0.1	-0.8	0.1	-0.6
Family relationship satisfaction	0.4	0.5	0.9	0.9	-0.8	0.4	-0.8	-0.4
Leg pain on walking	0.3	0.3	0.9	0.4	-0.5	0.9	-0.6	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.2	-0.8	0.6	-0.7	-0.8	1.5
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.0	-0.9	1.0	-0.8	-0.2	0.9
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	3.0	-1.5	1.3	1.6	-0.5	1.7
Medication: Aspirin	2.5	3.3	5.1	2.3	-2.0	-0.5	1.6	-2.1
Supplements: Vitamin C	1.0	1.2	1.7	1.3	-1.2	1.3	-0.1	-1.1
Knee pain experienced in last month	0.2	0.3	0.6	-0.6	0.8	-0.4	-0.0	0.5
Hypertension (Self-reported)	0.5	1.4	3.2	-0.8	0.5	1.4	-1.8	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.0	0.3	-0.8	-0.5	-1.7	0.7
Illnesses of father: Heart disease	1.2	1.6	4.2	0.7	-0.6	-0.1	2.0	-1.7
Illnesses of siblings: Diabetes	0.8	1.0	4.7	-0.2	0.0	-0.1	-2.2	0.6
Smoking status: Previous	0.1	0.1	0.4	-0.2	-0.1	0.6	-0.0	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.0	0.8	-0.8	0.1	1.7	-0.6
Whole body fat-free mass	0.6	3.4	5.2	2.0	-2.2	-0.7	2.3	-1.6
Leg fat-free mass (right)	0.3	1.5	4.2	0.9	-1.2	-0.4	2.0	-0.8
Arm fat percentage (left)	0.5	2.2	5.2	-1.6	1.3	-2.3	-0.6	1.2
Average weekly red wine intake	0.7	1.1	2.6	-0.8	1.1	-1.6	-0.2	0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-1.0	0.7	-0.5	-0.3	0.6
Mood swings	0.8	1.5	3.6	1.6	-1.9	0.8	-0.6	-0.7
Loneliness, isolation	2.1	2.9	9.6	1.2	-1.2	3.1	1.1	-1.0
Long-standing illness, disability or infirmity	0.8	1.2	3.8	0.9	-0.8	-0.9	-2.0	-0.2
Ever had bowel cancer screening	1.2	1.4	2.2	-1.2	1.2	1.0	-1.5	1.0
Diabetes diagnosed by doctor	0.9	1.5	3.8	0.8	-0.9	-2.0	1.0	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	2.8	-1.6	1.7	0.4	-0.2	0.8
Friendships satisfaction	1.5	1.8	4.6	0.8	-0.6	2.1	-1.9	-0.0
Qualifications: nursing, teaching	0.4	0.6	1.2	-0.6	0.9	1.1	-0.7	-0.5
Commuting to job workplace: Walk	0.3	0.4	0.7	-0.6	0.4	0.4	0.8	0.7
Eye problems/disorders: Cataract	0.1	0.1	0.4	0.2	-0.6	-0.2	-0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	3.1	0.3	-0.2	0.5	1.8	-0.6
Medication for cholesterol	0.4	0.7	2.3	-0.1	0.2	0.7	0.7	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.5	-0.0	0.4	0.4	0.7	-0.2
Back pain experienced in last month	0.4	0.6	0.9	0.8	-0.7	-0.9	-0.4	-0.9
Mineral and other dietary supplements	0.5	0.7	2.1	0.7	-0.7	-0.5	-0.4	-1.4
Breast cancer (self-reported)	0.1	0.1	0.3	-0.1	-0.0	-0.1	0.6	0.6
Asthma (self-reported)	0.3	0.6	1.6	-0.5	1.0	-0.1	-1.3	0.7
Osteoporosis (self-reported)	2.8	3.5	5.9	-2.2	2.4	1.5	-1.3	1.6
Osteoarthritis (self-reported)	0.9	1.2	2.4	1.5	-1.4	0.1	0.7	-0.9
Medication: Aspirin	1.9	2.5	4.2	2.0	-1.8	-0.2	1.2	-2.0
Medication: Gliclazide	0.3	0.3	0.6	-0.5	0.6	-0.3	0.4	0.8
Illnesses of father: None of the above (group 1)	1.0	1.2	1.7	1.1	-0.9	1.2	-1.3	0.8
Smoking status: Current	0.4	0.6	2.5	0.6	-0.5	0.2	0.3	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	5.8	1.9	-1.5	2.4	0.7	0.3
Whole body water mass	0.6	3.5	5.2	2.0	-2.2	-0.7	2.3	-1.6
Leg predicted mass (right)	0.3	1.4	4.3	0.9	-1.2	-0.3	2.1	-0.8
Arm fat mass (left)	0.4	1.7	7.4	-0.6	0.3	-2.7	0.4	0.6
Number of self-reported non-cancer illnesses	0.8	1.4	3.8	0.7	-0.6	-0.8	-1.3	-1.9
Average weekly champagne plus white wine intake	1.1	1.4	2.6	1.2	-0.8	-1.2	1.1	-1.6
Miserableness	1.1	1.9	3.5	1.4	-1.4	1.9	-1.5	-0.1
Guilty feelings	0.3	0.4	1.0	1.0	-0.9	-0.2	-0.1	-0.6
Wears glasses or contact lenses	1.0	1.2	2.6	0.9	-0.6	0.7	-1.3	-1.6
Ever taken oral contraceptive pill	0.4	0.5	1.6	0.1	-0.1	0.0	0.9	-1.3
Hearing aid user	1.6	1.9	4.5	-0.9	0.5	-0.9	-2.1	1.7
Mother’s age at death	0.8	1.0	1.7	-1.0	1.3	1.2	1.1	0.2
Financial situation satisfaction	0.7	0.9	2.7	0.6	-0.8	-0.2	-1.6	-0.8
Tinnitus: Yes, now most or all of the time	2.3	2.7	5.3	-2.2	2.3	0.0	-0.1	1.8
Commuting to job workplace: Public transport	0.2	0.2	0.8	-0.1	0.1	0.1	0.9	0.3
Eye problems/disorders: Glaucoma	0.1	0.2	0.7	0.0	0.2	0.8	0.3	-0.2
Medication: Blood pressure	0.3	0.6	2.5	0.3	-0.4	-0.1	-0.6	-1.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	-0.6	0.7	0.3	1.2	0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	-0.5	0.4	0.1	0.8	0.6
High cholesterol (Self-reported)	0.5	0.9	2.2	0.8	-1.0	-0.8	-0.3	-1.5
Medication: Bendroflumethiazide	0.3	0.5	1.0	-0.9	0.8	-0.4	-1.0	0.3
Medication: Paracetamol	1.8	2.8	6.1	1.7	-1.6	1.4	-0.8	-2.5
Medication: Lisinopril	1.0	1.3	4.0	0.1	-0.3	0.4	2.0	-1.6
Medication: Atorvastatin	0.4	0.5	1.6	-0.1	-0.0	-1.3	0.7	-0.8
Illnesses of father: High blood pressure	0.7	0.9	2.0	-1.4	1.3	-0.4	0.7	-0.1
Alcohol drinker status: Never	1.2	1.5	3.5	-1.2	1.1	-0.1	-1.9	1.2
Ever smoked	1.7	3.0	4.9	1.7	-1.8	2.2	1.0	-1.7
Basal metabolic rate	0.5	2.6	4.0	1.6	-1.9	-1.3	2.0	-1.2
Leg fat percentage (left)	0.7	2.6	12.4	0.1	-0.5	-3.5	-0.3	-0.1
Arm fat-free mass (left)	1.1	5.3	7.8	2.6	-2.8	-1.9	2.3	-1.8
Number of operations (self-reported)	1.0	1.4	2.5	1.4	-1.3	-1.6	1.1	-0.1
Average weekly beer plus cider intake	0.4	0.6	1.3	-0.3	0.6	0.8	1.1	-1.0
Irritability	0.8	1.3	3.2	1.2	-1.2	-0.7	-0.3	-1.8
Risk taking	0.1	0.2	0.7	0.0	-0.2	-0.3	0.3	0.8
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.6	-0.9	1.2	-1.3	-0.7	0.8
Fractured/broken bones in last 5 years	1.6	2.1	3.3	-1.8	1.8	0.2	-1.7	1.1
Age started oral contraceptive pill	1.0	1.2	3.3	-0.3	0.2	1.8	-1.5	0.7
Diastolic blood pressure, automated reading	0.2	0.6	1.1	-0.9	0.7	-0.2	-0.8	1.1
Ever depressed for a whole week	0.5	0.7	1.4	-0.7	1.0	0.5	-1.2	0.4
Unable to work because of sickness or disability	0.5	0.7	1.2	0.9	-1.1	0.2	-0.7	-0.9
Commuting to job workplace: Cycle	0.2	0.2	0.6	-0.1	-0.3	0.8	-0.3	0.7
Myopia	0.7	1.0	2.0	-1.4	1.4	-0.4	-0.7	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.2	1.0	-0.6	-1.1	1.5	0.3
Cholesterol lowering medication	1.3	2.0	5.9	-0.9	0.5	-1.6	-2.4	0.7
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	5.3	2.3	-2.3	0.5	0.2	-1.7
Pain experienced in last month	0.2	0.4	0.7	-0.5	0.2	0.7	-0.7	0.8
Supplements: Calcium	1.2	1.3	5.2	0.9	-0.6	0.6	-2.3	0.1
Basal cell carcinoma (self-reported)	0.9	1.0	3.4	-0.4	0.6	-1.8	-1.1	-0.4
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.7	1.2	-1.1	1.9	-1.2	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	1.3	-1.5	-0.8	-0.5	-0.5
Heart disease (siblings)	0.3	0.4	1.8	0.3	-0.1	-1.3	-0.4	-0.1
Alcohol drinker status: Previous	0.9	1.0	1.4	0.9	-0.9	1.1	-0.9	-1.2
Pack years of smoking	0.2	0.3	0.6	0.6	-0.8	-0.8	-0.4	-0.1
Impedance of whole body	0.5	2.4	3.9	-1.8	2.0	0.1	-1.3	1.8
Leg fat mass (left)	0.6	2.2	9.2	0.6	-1.0	-3.0	0.7	-0.4
Arm predicted mass (left)	1.0	5.2	8.2	2.7	-2.9	-1.4	2.2	-2.0