TWAS hub - FGFR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1210	0.0340	2.7e-05	0.002	0.055	0.046	0.059	0.023	1.7e-01	2.6e-07	2.2e-06	1.1e-07	6.8e-04
2	GTEx	Artery Tibial	0.1057	0.0422	6.2e-03	0.019	NA	0.046	NA	0.012	1.2e-02	NA	1.5e-04	NA	3.7e-02
3	GTEx	Brain Cerebellum	0.2590	0.1080	5.3e-03	-0.007	NA	0.006	NA	0.003	5.9e-01	NA	2.1e-01	NA	2.6e-01
4	NTR	Blood	0.0501	0.0152	1.5e-06	0.012	0.023	0.029	0.028	0.022	5.9e-05	5.5e-08	7.2e-10	1.8e-09	7.3e-08
5	TCGA	Prostate Adenocarcinoma	0.0801	0.0336	5.3e-04	0.034	0.042	0.054	NA	0.034	1.7e-04	2.8e-05	2.2e-06	NA	1.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Average weekly beer plus cider intake	6.1	8.9	19.3	2.4	2.6	2.9	2.1	4.4
Prostate Cancer	4.4	6.1	18.3	-4.3	-0.5	-3.5	0.1	-0.3
Cholesterol lowering medication	4.0	5.9	14.0	1.6	1.5	1.4	3.7	3.0
Alcohol usually taken with meals	3.9	6.4	17.2	-1.2	-2.6	-2.2	-1.3	-4.1
Diabetes (mother)	3.8	4.9	11.6	2.3	3.4	1.7	0.5	2.0
Noisy workplace	3.8	4.7	6.5	2.2	2.3	1.9	1.7	2.6
Hearing difficulty/problems with background noise	3.4	5.5	8.6	2.3	2.6	2.9	1.4	2.2
Wears glasses or contact lenses	3.4	3.9	7.3	0.2	-2.4	-2.7	0.2	-2.5
Gout (self-reported)	3.3	4.5	8.5	2.1	-0.2	2.7	2.9	1.6
Age at First Birth	3.1	4.5	6.8	-2.0	-2.6	-2.6	-0.9	-2.1
Glaucoma (self-reported)	3.1	3.6	4.9	2.2	1.6	2.0	1.7	1.9
Lupus	3.0	4.5	9.5	-3.1	-2.0	-2.1	-1.1	-1.8
Medication for hormone replacement therapy	3.0	3.4	6.6	1.0	1.0	1.3	2.6	2.6
Rheumatoid Arthritis	2.9	4.0	17.0	0.9	4.1	0.7	0.3	1.3
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	7.6	1.9	1.7	2.8	0.9	0.9
Comparative body size at age 10	2.8	7.8	28.3	0.6	0.7	0.1	3.1	5.3
Leg pain on walking	2.7	3.4	6.2	1.9	2.0	-0.5	1.7	2.5
Lung FEV1/FVC ratio	2.6	13.3	31.4	2.2	3.0	2.1	4.1	5.6
Bipolar Disorder (2018)	2.5	3.9	12.6	-1.5	0.9	3.5	-0.8	-1.8
Mouth/teeth dental problems: Dentures	2.5	4.3	6.2	0.9	1.8	-2.5	2.5	2.3
Ever used hormone-replacement therapy (HRT)	2.4	3.0	4.9	1.7	1.1	1.6	2.2	1.9
Angina	2.4	3.1	9.5	1.1	1.8	1.2	0.7	3.1
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.1	14.2	1.0	1.9	3.8	-2.2	-1.3
Medication for cholesterol	2.4	3.7	10.2	-1.4	-1.2	-0.2	-3.2	-2.2
Townsend deprivation index at recruitment	2.3	3.3	7.7	1.1	2.0	-0.3	1.8	2.8
Number of incorrect matches in round	2.3	3.8	18.6	-4.3	0.3	0.2	-0.4	0.6
Medication: Ventolin 100micrograms inhaler	2.3	2.9	9.6	0.6	3.1	0.9	-1.9	0.6
Breast cancer (self-reported)	2.3	2.8	5.3	-1.2	-2.3	-1.7	-0.5	-2.0
Medication: Levothyroxine sodium	2.2	3.8	14.7	-3.8	0.2	-1.0	-1.2	1.3
Average weekly fortified wine intake	2.1	2.5	5.9	-0.3	-0.6	-0.7	-2.4	-2.4
Taking other prescription medications	2.1	3.2	8.2	0.7	2.9	1.9	-1.0	1.8
Worrier / anxious feelings	2.1	3.9	9.1	-1.1	-0.5	0.6	-2.9	-3.0
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	8.6	-0.3	-0.6	-1.6	-1.0	-2.9
Angina (self-reported)	2.1	2.8	8.6	0.7	1.8	1.2	0.4	2.9
Pain all over the body in last month	2.0	2.2	5.7	0.6	1.9	1.1	0.2	2.4
Alcohol intake frequency.	2.0	4.6	12.4	1.1	3.0	0.0	-0.5	3.5
Alzheimer’s Disease (in father)	1.9	2.0	4.5	1.7	0.2	-0.0	2.1	1.6
Mean Putamen Volume	1.9	2.2	5.0	0.8	2.2	2.2	-0.5	0.3
Smoking Status	1.9	4.4	9.2	-0.1	2.1	0.5	2.8	3.0
Medication: Seretide 50 evohaler	1.9	2.2	6.2	2.5	-1.4	-0.5	1.6	0.2
Commuting to job workplace: Public transport	1.9	2.2	4.6	0.0	-1.7	-1.8	-0.6	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	7.5	1.0	0.8	-0.0	-2.7	1.2
Medication: Aspirin	1.8	2.4	4.4	1.2	1.0	1.1	2.1	1.9
Mouth/teeth dental problems	1.7	2.6	6.2	-1.0	-2.5	0.8	-1.9	-1.3
Birth weight	1.7	3.7	8.4	-1.2	1.6	2.9	-2.2	-1.0
Leg fat mass (right)	1.7	6.5	16.2	0.7	4.0	1.3	0.7	3.7
Long-standing illness, disability or infirmity	1.7	2.6	5.6	1.6	1.5	-0.1	1.5	2.4
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	5.0	2.2	0.9	0.4	1.4	1.5
Leg fat mass (left)	1.7	6.6	16.5	0.6	4.1	1.4	0.6	3.7
Schizophrenia vs Biploar Disorder	1.6	2.1	6.5	-0.0	-1.8	-2.5	-1.0	-0.3
BMI	1.6	9.1	23.4	1.6	3.4	2.4	1.5	4.8
Waist Hip Ratio (WHR)	1.6	7.2	15.8	3.0	-0.1	-1.0	4.0	3.2
Body mass index (BMI)	1.6	6.7	17.5	0.3	3.7	0.7	1.4	4.2
Waist circumference	1.6	5.8	15.0	1.2	3.1	1.1	1.4	3.9
Age at last live birth	1.6	2.3	3.8	-1.8	-1.1	-0.6	-2.0	-1.7
Asthma (self-reported)	1.6	3.2	6.6	2.6	2.5	1.3	-1.0	0.7
Medication: Atorvastatin	1.6	1.9	4.0	2.0	0.4	0.9	1.8	1.2
Hearing difficulty/problems: Yes	1.5	2.4	4.3	1.7	0.9	2.1	0.6	1.8
Current tobacco smoking	1.5	2.4	6.9	-0.3	1.6	0.4	2.6	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	5.6	2.0	1.3	0.3	2.4	2.2
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	6.2	2.4	1.2	0.2	2.5	1.9
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	6.6	-0.4	0.3	-0.1	-2.6	-1.7
Asthma	1.5	3.0	6.5	2.3	2.5	1.2	-1.1	0.5
Breastfed as a baby	1.5	1.8	6.2	-1.2	-1.0	-0.3	-0.6	-2.5
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	8.9	-3.0	-0.5	-0.6	-2.2	-0.0
Wheeze or whistling in the chest in last year	1.5	2.7	7.2	1.0	2.7	0.9	1.9	1.0
Age at first live birth	1.5	2.7	4.1	-1.3	-1.5	-1.7	-2.0	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	3.0	1.3	0.5	-1.1	1.7	1.6
Had menopause	1.4	1.7	4.6	1.8	-0.6	0.5	2.1	-0.1
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	5.3	0.3	1.8	0.4	2.3	1.6
Ever highly irritable/argumentative for 2 days	1.4	1.6	3.5	1.5	0.1	0.8	1.3	1.9
Leg fat percentage (right)	1.4	5.2	12.2	1.0	3.5	0.2	1.3	3.4
Exposure to tobacco smoke outside home	1.4	1.9	5.3	1.9	-0.1	2.3	-0.4	-0.7
Medication: Allopurinol	1.4	1.8	4.5	1.0	-0.9	2.1	1.7	0.1
Medication: Omeprazole	1.4	1.7	4.4	2.1	1.1	0.6	0.2	1.6
Chest pain or discomfort	1.4	2.0	5.4	0.2	2.3	0.8	1.3	1.5
Back pain experienced in last month	1.4	2.0	3.8	-1.1	1.5	-1.6	1.9	0.7
Osteoarthritis (self-reported)	1.4	1.9	4.6	0.9	2.2	0.5	1.3	1.4
Medication: Aspirin	1.4	1.9	3.6	0.9	0.8	1.0	1.9	1.9
Medication: Gliclazide	1.4	1.6	2.3	0.2	1.5	1.2	1.3	1.5
Arm fat mass (left)	1.4	5.7	14.0	0.5	3.7	0.9	0.9	3.6
Average weekly champagne plus white wine intake	1.4	2.0	3.5	-1.0	-1.9	-1.1	-1.2	-1.6
Leg fat percentage (left)	1.4	5.0	12.2	0.7	3.5	0.1	1.1	3.3
Heart disease (siblings)	1.4	1.8	4.6	-0.1	0.2	-1.0	2.1	1.8
Systolic Blood Pressure	1.3	6.4	13.4	-0.1	-2.6	-3.7	-0.6	-3.4
Hypothyroidism (self reported)	1.3	3.0	8.0	-2.5	-0.6	-0.0	-2.8	-0.6
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.2	0.9	1.8	0.7	1.5	1.5
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	3.7	1.9	1.3	0.8	0.8	1.2
Ever had hysterectomy (womb removed)	1.3	1.5	2.5	-1.6	-1.3	-1.0	-0.0	1.5
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.3	0.5	1.1	-1.4	1.4	1.5
Qualifications: CSEs or equivalent	1.3	1.8	7.9	0.4	0.3	2.8	-0.5	-0.6
Stomach or abdominal pain in last month	1.3	1.6	3.8	-0.0	1.5	1.3	0.5	2.0
Arm fat mass (right)	1.3	5.5	13.7	0.6	3.7	1.3	0.7	3.4
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.8	1.9	-0.8	1.0	1.1	-0.9
Whole body fat mass	1.3	5.5	13.3	0.8	3.6	1.4	0.8	3.3
Average weekly red wine intake	1.3	1.9	7.2	-0.4	-1.5	0.0	0.2	-2.7
Loneliness, isolation	1.3	1.7	4.3	1.3	2.1	0.4	-0.6	1.5
Age started oral contraceptive pill	1.3	1.6	4.8	2.2	-1.0	0.1	0.6	-1.4
Medication: Metformin	1.2	1.7	3.6	0.1	1.9	1.1	0.8	1.8
Serious illness, injury or assault to yourself	1.2	1.4	2.4	1.1	1.2	0.8	1.5	1.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.2	1.1	1.5	1.2	0.7	1.4
Arm fat percentage (right)	1.2	4.7	10.4	0.7	3.2	0.6	1.3	3.2
Hair/balding pattern: Pattern 3	1.2	1.8	7.9	-0.8	-0.3	0.5	-2.8	-0.6
Happiness	1.2	1.5	4.8	-0.2	-1.4	-0.5	-0.6	-2.2
Tense / ‘highly strung’	1.2	2.0	5.3	-1.0	0.2	2.3	-1.8	-0.3
Overall health rating	1.2	2.5	9.8	-0.1	3.1	0.1	-0.0	1.7
Illnesses of father: Heart disease	1.2	1.7	4.7	-2.2	1.2	-0.4	0.7	1.3
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.3	1.0	-0.2	-1.5	1.8	0.6
Smoking status: Current	1.2	2.0	7.0	-0.3	1.1	0.1	2.6	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	9.5	3.1	-0.6	0.4	1.3	0.8
Guilty feelings	1.2	1.8	4.0	1.4	0.5	2.0	1.5	0.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.8	-1.5	0.8	0.1	0.6	2.0
HbA1C	1.1	1.2	2.6	-1.6	-0.7	0.9	0.3	-1.4
Type 2 Diabetes (T2D) (2018)	1.1	2.0	6.0	-0.3	2.5	-0.2	1.2	1.6
Medication: Simvastatin	1.1	1.6	2.3	-0.0	1.5	1.4	1.3	1.5
Illnesses of siblings	1.1	1.5	3.2	-1.0	-1.1	-0.0	-1.5	-1.8
Weight	1.1	5.2	13.9	0.2	3.7	2.1	-0.5	2.7
Alcohol intake versus 10 years previously	1.1	1.7	5.9	-0.0	1.3	0.4	0.8	2.4
Number of live births	1.1	1.6	3.7	1.9	-1.6	0.8	-0.2	-1.1
Pulse rate	1.1	1.8	4.0	0.2	-2.0	-1.0	1.1	-1.7
Birth weight of first child	1.1	2.0	3.7	-1.9	-0.0	1.6	-1.8	-0.8
Body fat percentage	1.1	4.3	10.6	0.7	3.3	0.4	1.0	3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	2.1	-0.2	1.5	1.5	-1.1	1.3
Medication for pain relief, constipation, heartburn	1.1	1.8	3.0	-1.6	-1.2	-0.9	-1.7	-1.1
Number of full sisters	1.1	1.3	3.7	-0.2	1.4	1.0	0.1	1.9
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.9	-0.1	-1.4	0.3	-2.0	-0.7
Arm fat percentage (left)	1.1	4.5	10.6	0.6	3.2	0.3	1.1	3.3
Qualifications: nursing, teaching	1.1	1.7	4.7	-0.1	0.0	-1.9	2.2	-0.1
Number of self-reported non-cancer illnesses	1.1	2.0	5.4	2.3	0.8	1.8	-0.1	0.8
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.8	-2.0	-0.1	-1.2	1.0	1.1
Number of operations (self-reported)	1.1	1.7	6.1	-0.8	0.9	-0.8	0.6	2.5
Pain experienced in last month	1.1	1.9	4.9	1.7	-2.2	-0.6	-0.5	-1.1
Bipolar Disorder or Schizophrenia	1.0	2.5	9.2	-1.2	0.1	3.0	-1.0	-1.0
Body Mass Index (BMI) (2010)	1.0	1.3	2.3	1.3	-0.6	0.7	1.5	1.5
Triglycerides	1.0	1.6	3.6	0.4	0.2	1.2	1.7	1.9
Pack years adult smoking proportion	1.0	1.6	3.9	0.6	0.4	1.8	2.0	0.4
High blood pressure (mother)	1.0	1.4	4.2	-0.1	-1.5	-0.5	-0.5	-2.1
Trunk fat mass	1.0	4.5	12.3	0.5	3.5	1.4	0.1	2.8
Hair/balding pattern: Pattern 2	1.0	1.3	3.7	1.9	-1.1	-0.3	1.3	-0.3
Falls in the last year	1.0	1.4	2.4	-0.9	1.1	1.5	1.5	0.4
Worry too long after embarrassment	1.0	1.7	6.5	1.0	-0.1	2.5	-0.7	-0.5
Pulse wave peak to peak time	1.0	1.1	1.7	-0.6	-1.2	1.1	-1.0	-1.3
Qualifications: College or University degree	1.0	3.0	6.3	-1.8	-1.2	-0.4	-1.9	-2.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.6	0.7	0.7	-1.6	1.6	0.2
Heart disease (mother)	1.0	1.2	3.0	0.4	-0.9	-1.7	1.1	-1.0
Illnesses of siblings: Diabetes	1.0	1.2	2.4	0.1	1.5	-1.0	0.0	1.5
Illnesses of father: High blood pressure	1.0	1.2	4.7	-0.2	-0.6	-0.7	-0.6	-2.2
Major Depression (MDD)	0.9	1.1	3.2	0.0	0.7	0.5	1.8	1.3
HDL Cholesterol	0.9	1.5	3.0	-0.6	-0.6	-1.2	-1.5	-1.7
Number of treatments/medications taken	0.9	1.7	5.0	1.3	2.2	1.0	0.5	0.7
Trunk fat percentage	0.9	3.5	9.8	0.5	3.1	0.6	0.6	2.6
Fed-up feelings	0.9	1.6	5.1	1.5	2.3	0.7	0.5	0.4
Past tobacco smoking	0.9	1.6	4.5	0.2	-1.3	0.1	-1.4	-2.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.2	-0.1	1.2	0.8	1.2	1.8
Had other major operations	0.9	1.1	2.4	-1.4	0.4	-1.5	0.3	1.1
Diabetes (self-reported)	0.9	1.4	3.3	-0.3	1.8	1.7	0.5	0.7
Medication: Ramipril	0.9	1.1	2.0	1.2	-0.3	-1.4	0.8	1.2
Hip circumference	0.9	3.9	12.2	-0.0	3.5	1.8	-0.8	1.9
Number of children fathered	0.9	1.0	2.3	0.5	-0.2	1.5	-0.4	-1.5
Shortness of breath walking on level ground	0.9	1.0	2.4	0.2	0.6	-0.2	1.6	1.5
Migraine (self-reported)	0.9	1.2	2.6	1.0	-1.0	-0.2	-1.6	-1.1
Comparative height size at age 10	0.9	5.0	15.0	0.2	2.1	3.9	-2.4	-0.0
Commuting to job workplace: Walk	0.9	0.9	3.4	1.8	0.5	-0.5	0.8	0.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	5.9	2.4	0.4	1.1	0.2	-0.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.6	1.4	-0.2	0.9	-0.2	1.6
Ever taken oral contraceptive pill	0.9	1.0	2.5	0.6	0.1	1.6	1.0	-1.0
Ever smoked	0.9	1.6	2.9	0.9	1.0	0.8	1.7	1.7
Risk taking	0.9	1.3	3.6	-0.3	1.0	1.9	0.9	1.0
Unable to work because of sickness or disability	0.9	1.2	2.5	1.2	1.6	-0.4	0.8	1.1
Pack years of smoking	0.9	1.3	3.8	0.8	0.1	1.4	1.9	0.1
Irritable Bowel Disease (IBD)	0.8	2.0	8.0	-1.1	0.8	0.5	-2.8	0.1
Breast Cancer	0.8	2.0	3.6	1.3	1.1	1.9	1.4	1.3
Primary Biliary Cirrhosis	0.8	1.2	4.2	-0.4	-2.0	0.8	-0.2	-1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.0	-0.7	0.9	-0.4	1.4	1.1
Height	0.8	14.6	44.2	-0.9	-0.2	3.2	-6.7	-4.2
Average weekly spirits intake	0.8	0.9	1.9	-0.6	-0.2	0.9	-1.3	-1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.8	0.2	0.4	1.3	-1.3	-0.7
Medication: Co-codamol	0.8	1.0	2.5	1.6	0.8	1.0	0.1	0.9
Hayfever, allergic rhinitis or eczema	0.8	1.6	5.2	-0.0	-0.1	0.5	-2.3	-1.6
Supplements: Glucosamine	0.8	1.0	2.8	0.2	-1.7	-0.1	-0.1	-1.5
Medication: Atenolol	0.8	1.1	3.0	1.7	-0.5	-0.2	1.0	1.0
Nervous feelings	0.8	1.4	3.3	0.2	1.2	1.5	-1.8	0.5
Loud music exposure frequency	0.8	0.9	2.5	-0.1	0.1	-0.1	1.6	1.4
Health satisfaction	0.8	1.1	2.4	-0.1	0.5	-1.1	1.5	1.3
Smoking status: Previous	0.8	1.2	3.9	0.3	1.1	0.3	0.7	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.4	0.7	0.2	1.3	0.5	1.5
Basal metabolic rate	0.8	4.4	9.7	0.2	3.1	2.7	-0.8	2.1
Arm fat-free mass (left)	0.8	4.3	10.1	0.2	3.2	2.5	-0.8	2.1
Commuting to job workplace: Cycle	0.8	1.0	3.3	0.1	-0.2	0.3	1.8	1.3
Basal cell carcinoma (self-reported)	0.8	1.0	3.5	1.0	-0.4	-0.1	-0.6	-1.9
Alcohol drinker status: Previous	0.8	0.9	1.3	1.0	1.0	0.5	-1.2	0.9
Arm predicted mass (left)	0.8	4.3	10.6	-0.2	3.3	2.5	-1.2	1.9
Worry (Nagel 2018)	0.7	1.4	3.9	-0.9	0.1	1.3	-2.0	-0.8
Ulcerative Colitis (UC)	0.7	1.3	5.0	-1.0	0.6	-0.0	-2.2	0.1
Respiratory disease	0.7	1.5	3.1	1.1	1.8	0.7	-1.6	-0.2
Leg fat-free mass (left)	0.7	3.8	6.8	0.4	2.6	2.6	-0.7	2.2
Maternal smoking around birth	0.7	1.0	2.6	-1.1	-1.6	0.1	1.0	0.1
Relative age voice broke	0.7	1.1	2.2	0.9	0.5	0.7	-1.3	-1.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.8	-0.3	-1.7	-1.2	-0.1	0.3
Leg predicted mass (left)	0.7	3.8	6.8	0.4	2.6	2.6	-0.7	2.2
Forced vital capacity (FVC)	0.7	2.8	7.6	0.3	-0.6	0.7	-2.3	-2.8
Financial difficulties in last 2 years	0.7	0.9	2.8	0.1	1.1	0.6	1.7	0.1
Neuroticism score	0.7	1.4	3.1	0.3	1.7	1.8	0.7	0.8
Illnesses of mother	0.7	0.9	1.5	-1.1	0.0	1.2	-0.3	1.2
Pulse wave Arterial Stiffness index	0.7	0.9	1.3	0.8	1.1	-0.9	0.7	1.0
Exposure to tobacco smoke at home	0.7	0.8	1.8	1.0	1.3	0.2	0.9	0.2
Arm fat-free mass (right)	0.7	3.7	8.3	-0.2	2.9	2.4	-1.4	1.5
Arm predicted mass (right)	0.7	3.7	8.5	-0.1	2.9	2.4	-1.0	1.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.5	0.9	1.1	-0.9	1.2	0.1
Leg fat-free mass (right)	0.7	3.6	6.7	0.2	2.5	2.6	-0.7	2.1
Whole body water mass	0.7	3.8	7.7	0.1	2.7	2.8	-0.9	1.8
Leg predicted mass (right)	0.7	3.6	6.9	0.2	2.5	2.6	-0.7	2.0
Mother’s age at death	0.7	0.8	2.8	1.7	0.5	0.9	0.5	0.1
High cholesterol (Self-reported)	0.7	1.2	1.8	-1.2	0.5	-1.1	1.3	1.2
Medication: Bendroflumethiazide	0.7	1.0	3.3	0.4	-0.7	-1.8	0.6	-0.7
Medication: Lisinopril	0.7	0.9	2.4	0.2	-1.4	-0.1	-0.2	-1.5
Crohns Disease (2017)	0.6	1.4	5.2	-1.1	0.2	0.5	-2.3	-0.1
Reaction Time	0.6	1.2	4.5	0.3	-0.3	-0.8	-2.1	-0.7
Verbal and Numeric Reasoning (VNR)	0.6	1.3	5.4	-0.9	0.0	-2.3	0.4	-0.5
Cardiovascular Disease	0.6	2.0	5.6	0.7	-0.4	-2.4	1.4	1.2
Chronotype (morning person)	0.6	1.5	4.2	-1.1	-0.9	-2.1	-1.0	0.1
Age when periods started (menarche)	0.6	1.4	2.8	1.1	0.5	1.6	-0.4	-1.7
Fluid intelligence score	0.6	1.2	4.3	-1.1	0.3	-2.1	0.4	-0.3
Impedance of arm (right)	0.6	2.9	7.0	1.0	-2.4	-0.8	-0.3	-2.6
Trunk fat-free mass	0.6	3.5	7.8	0.2	2.6	2.8	-1.3	1.1
Father’s age at death	0.6	0.8	1.7	1.1	-0.4	0.1	-1.3	-1.0
Lung cancer (father)	0.6	0.6	1.7	-1.3	-0.1	-0.3	-1.2	-0.1
Impedance of arm (left)	0.6	2.7	6.9	0.9	-2.1	-1.2	-0.7	-2.6
Trunk predicted mass	0.6	3.5	7.6	0.3	2.7	2.8	-1.3	1.1
Standing height	0.6	6.4	14.5	0.3	0.5	3.2	-3.8	-2.6
Length of working week for main job	0.6	0.7	1.6	-0.4	-0.4	1.1	0.2	1.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.8	-1.3	0.7	-0.6	0.1	-1.1
Had major operations	0.6	0.7	1.4	-0.8	1.0	0.7	0.5	1.2
Whole body fat-free mass	0.6	3.6	7.2	0.2	2.7	2.7	-1.1	1.6
Mood swings	0.6	1.1	2.5	-0.1	1.6	1.3	1.0	0.7
Diabetes diagnosed by doctor	0.6	1.0	2.5	-0.3	1.6	0.9	0.6	1.1
Miserableness	0.6	1.1	1.8	1.2	1.4	1.2	0.9	0.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.7	0.9	0.7	0.5	0.5	1.3
Medication: Blood pressure	0.6	1.0	2.5	1.4	-0.2	-0.8	1.6	0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.8	0.9	0.9	1.3	0.2	0.6
Depression (Nagel 2018)	0.5	0.8	2.7	0.4	0.7	0.6	1.7	0.2
Ovarian Cancer	0.5	0.6	1.9	0.3	0.1	1.4	1.0	-0.4
LDL Cholesterol	0.5	0.8	1.2	0.9	-0.8	-1.1	1.1	0.5
Heel T-Score	0.5	4.3	12.2	1.6	0.1	-1.8	3.5	1.8
Lung FVC	0.5	2.8	7.7	0.4	-1.9	-1.6	-0.3	-2.8
Relative age of first facial hair	0.5	1.0	2.1	-0.9	-1.4	-1.3	0.0	-0.6
Systolic blood pressure, automated reading	0.5	1.5	3.3	-0.3	-0.8	-1.8	-0.1	-1.8
Vitamin and mineral supplements	0.5	0.6	1.5	-0.2	-1.2	-0.1	-0.7	-1.1
Diabetes (father)	0.5	0.6	1.9	0.4	0.7	-1.4	0.6	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.3	0.5	1.1	1.1	0.3	0.5
Allergy	0.5	1.1	2.6	-0.5	-0.8	-1.2	1.6	0.8
Time employed in main current job	0.5	0.6	1.1	-1.0	-1.0	0.0	-0.9	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.2	-0.5	-0.4	-1.8	-0.7	-1.3
Prospective memory result	0.5	0.6	1.1	0.1	-1.1	0.7	1.0	0.7
Medication: Paracetamol	0.5	0.9	2.5	-0.1	1.6	-1.3	0.5	-0.1
High blood pressure (siblings)	0.5	0.8	1.9	1.4	-0.2	0.4	1.2	-0.6
Forced vital capacity (FVC), Best measure	0.5	1.9	4.8	1.0	-1.2	0.9	-1.3	-2.2
Mean time to correctly identify matches	0.5	0.9	3.2	-0.1	-0.5	-1.0	-1.8	0.1
Suffer from ‘nerves’	0.5	0.8	1.9	-0.9	0.0	-1.0	-1.4	0.7
Supplements: Vitamin C	0.5	0.6	1.5	-0.9	-0.4	0.0	-0.6	-1.2
Ever had bowel cancer screening	0.5	0.5	1.7	0.0	0.4	-0.5	-0.8	1.3
Friendships satisfaction	0.5	0.6	1.5	-1.2	0.6	-0.7	-0.8	-0.1
Eye problems/disorders: Cataract	0.5	0.6	2.4	1.6	0.1	0.6	-0.1	0.2
Financial situation satisfaction	0.5	0.6	1.6	0.6	0.1	-1.0	1.3	0.5
Myopia	0.5	0.8	2.5	-0.6	0.6	-0.7	1.6	-0.5
Supplements: Calcium	0.5	0.5	1.0	-1.0	0.0	0.9	0.3	1.0
Impedance of whole body	0.5	2.7	8.8	0.4	-1.7	-1.0	-0.8	-3.0
Neuroticism (Nagel 2018)	0.4	0.9	3.2	0.4	-0.1	1.8	-0.3	-1.0
Alzheimer’s Disease (including proxy)	0.4	0.5	1.1	1.0	0.4	-0.2	0.7	1.0
Blood Eosinophil Count	0.4	3.3	7.0	1.0	2.2	1.5	1.2	2.6
Blood White Count	0.4	2.6	5.0	1.9	2.0	0.4	2.2	0.4
Impedance of leg (right)	0.4	1.9	7.2	0.7	-1.2	-0.3	-0.7	-2.7
High blood pressure	0.4	1.0	2.0	1.4	0.4	-0.7	1.4	0.4
Multivitamins +/- minerals	0.4	0.5	1.6	0.4	1.3	-0.0	0.1	0.8
Impedance of leg (left)	0.4	2.0	7.7	0.2	-1.0	-0.4	-0.9	-2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.9	-0.7	0.0	1.4	-0.5	0.4
Hair/balding pattern: Pattern 4	0.4	1.1	3.0	-0.2	1.7	0.1	1.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.8	-1.0	-0.4	-1.3	-0.1	-0.7
Eye problems/disorders: None of the above	0.4	0.5	1.0	-1.0	-0.7	-0.8	-0.7	0.2
Medication: Blood pressure	0.4	0.8	1.7	1.3	-0.6	-1.3	0.1	0.4
Hypertension (Self-reported)	0.4	1.0	2.3	1.5	0.2	-1.0	1.2	0.6
Mineral and other dietary supplements	0.4	0.6	1.1	0.8	-0.2	0.5	-0.9	-1.1
Osteoporosis (self-reported)	0.4	0.4	1.0	0.6	0.5	0.5	-0.5	1.0
Medication: Paracetamol	0.4	0.7	1.9	-0.1	1.4	-1.0	0.4	0.3
Irritability	0.4	0.7	1.8	-0.8	0.4	1.4	0.9	0.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.0	0.8	-0.4	-1.0	-0.1	-0.5
Ever depressed for a whole week	0.4	0.5	1.7	0.7	0.0	-0.5	-0.4	1.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.0	-1.4	-0.0	0.5	-1.3	-1.1
Depressed Affect (Nagel 2018)	0.3	0.6	1.5	0.5	1.0	0.5	1.2	-0.2
Neuroticism (2016)	0.3	0.5	1.8	-0.3	0.3	1.4	-0.5	-0.1
Ulcerative Colitis	0.3	0.5	1.1	0.4	0.2	-1.0	-1.1	0.0
Neuroticism	0.3	0.8	2.0	-0.6	1.4	1.3	-0.3	0.1
Supplements: Zinc	0.3	0.3	0.5	-0.5	-0.7	-0.5	-0.3	-0.6
Hand grip strength (right)	0.3	0.9	2.2	0.5	0.4	1.3	-1.5	-0.5
Qualifications: None of the above	0.3	0.6	1.8	1.3	0.1	0.5	-0.2	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.5	-0.7	0.5	-0.3	-0.6	-0.5
Depression (self-reported)	0.3	0.4	0.9	-0.0	1.0	0.2	-0.9	-0.1
Medication: Lansoprazole	0.3	0.3	0.7	-0.2	0.5	0.8	0.8	0.1
Pulse wave reflection index	0.3	0.4	0.7	0.2	0.6	-0.8	0.3	0.8
Headache pain in last month	0.3	0.4	1.1	-0.2	0.6	1.1	-0.7	-0.5
Medication: Amlodipine	0.3	0.4	1.1	0.7	-0.3	-0.2	0.6	-1.0
Emphysema/chronic bronchitis	0.3	0.3	0.8	-0.4	-0.7	-0.9	-0.0	0.4
Pulse rate, automated reading	0.3	1.1	4.4	0.7	-0.5	-0.6	0.2	-2.1
Family relationship satisfaction	0.3	0.4	1.8	1.3	-0.4	-0.2	-0.2	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	-0.4	0.8	0.8	-0.4	0.5
Alcohol drinker status: Never	0.3	0.4	0.7	0.7	0.2	0.8	-0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.7	0.9	-0.3	-0.4	0.5	-0.6
Schizophrenia (2018)	0.2	0.3	1.0	-0.2	-0.4	1.0	-0.6	0.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.0	0.3	-0.7	-0.6	-0.2
Coronary Artery Disease (CAD)	0.2	0.2	0.8	-0.0	0.2	0.9	-0.6	0.3
Crohns Disease (2012)	0.2	0.3	1.2	-0.3	0.0	1.1	-0.6	-0.4
Fasting Glucose	0.2	0.2	0.6	-0.3	-0.8	0.5	-0.0	-0.0
Allergy or Eczema	0.2	0.6	1.6	0.2	0.4	0.1	-1.3	-1.0
Hair Pigment	0.2	4.9	14.0	-2.6	-0.1	-0.1	-3.7	-1.9
Sensitivity / hurt feelings	0.2	0.4	1.4	-0.3	-0.2	0.5	1.2	-0.2
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	0.7	0.5	0.7	-0.2	-0.4
Heart attack	0.2	0.3	0.5	-0.4	-0.7	-0.3	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.8	0.9	0.4	0.9	-0.9	-0.9
Medication: Cholesterol lowering	0.2	0.3	0.9	-0.5	0.3	0.3	-0.2	0.9
Peak expiratory flow (PEF)	0.2	0.6	1.4	1.2	0.5	1.1	0.0	0.2
Neck or shoulder pain in last month	0.2	0.2	0.8	-0.3	0.4	0.2	0.9	-0.3
Medication: Ibuprofen	0.2	0.2	0.3	0.1	-0.5	0.6	-0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.5	-0.7	-0.2	-0.3	0.2
Diastolic blood pressure, automated reading	0.2	0.7	1.6	0.7	-0.5	-0.2	1.3	-1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	-0.1	-0.6	-0.5	-0.2	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	-0.9	0.9	-0.5	0.5	-0.0
Schizophrenia (2014)	0.1	0.3	0.7	-0.8	0.2	0.6	-0.4	0.6
Blood Platelet Count	0.1	1.7	4.2	-1.2	-0.1	-0.9	-1.4	-2.0
Blood Red Count	0.1	1.3	2.0	0.0	1.3	-1.2	-1.4	1.1
Tanning	0.1	1.5	2.6	-1.2	-1.2	-1.5	0.1	-1.6
Hand grip strength (left)	0.1	0.3	1.1	0.7	-0.1	1.0	-0.2	0.2
Severe depression (siblings)	0.1	0.1	0.1	-0.2	-0.1	0.3	0.3	0.3
Sitting height	0.1	0.5	1.4	0.0	0.5	1.2	-0.9	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.3	-0.5	-0.2	0.1	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	0.7	0.8	-0.7	0.7	-0.3	-0.7
Blood clot in the leg (DVT)	0.1	0.2	0.4	0.7	-0.1	-0.1	0.4	-0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	0.1	0.1	0.3	0.5	-0.6
Number of full brothers	0.1	0.2	0.6	0.3	-0.1	-0.7	0.1	0.5
Knee pain experienced in last month	0.1	0.2	0.4	-0.2	-0.1	-0.6	0.6	-0.3
Hearing aid user	0.1	0.1	0.3	0.4	-0.1	0.5	-0.3	0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.4	-0.0	0.3	-0.1	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

FGFR1

Models

Trait associations