Hub : Genes

FGFR1OP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0415 0.0221 0.0310 0.000 0.002 0.000 0.004 -0.001 0.31000 0.140 0.30000 0.079 0.45000
2 TCGA Brain Lower Grade Glioma 0.0493 0.0245 0.0062 0.023 0.013 0.031 NA 0.026 0.00097 0.012 0.00016 NA 0.00048

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.0 1.6 3.1 1.8 -0.3
Bipolar Disorder or Schizophrenia 0.7 1.7 2.5 1.6 -1.0
Depressed Affect (Nagel 2018) 0.0 0.0 0.1 0.2 -0.1
Depression (Nagel 2018) 0.2 0.3 0.6 0.8 -0.3
Intelligence (Savage-Jansen 2018) 0.0 0.0 0.0 0.1 -0.2
Neuroticism (Nagel 2018) 0.7 1.7 2.8 1.7 -0.7
Schizophrenia (2018) 0.3 0.7 1.0 0.6 -1.0
Schizophrenia vs Biploar Disorder 0.3 0.4 0.6 -0.8 0.4
Worry (Nagel 2018) 1.9 3.9 6.2 2.5 -1.3
Alzheimer’s Disease (in mother) 1.6 1.8 2.2 1.2 -1.5
Alzheimer’s Disease (in father) 0.6 0.6 0.7 0.8 0.8
Alzheimer’s Disease (including proxy) 0.8 1.2 1.7 1.3 -0.9
Crohns Disease (2017) 0.4 0.9 0.9 -1.0 -0.9
Irritable Bowel Disease (IBD) 0.1 0.2 0.3 -0.2 -0.6
Ulcerative Colitis (UC) 0.6 1.1 1.8 1.3 -0.7
Major Depression (MDD) 1.2 1.5 1.8 1.1 -1.4
Reaction Time 1.2 2.3 2.3 -1.5 1.5
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.1 0.4 0.2
Breast Cancer 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.9 1.1 2.2 1.5 -0.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.9 1.3 2.5 0.4 -1.6
Bipolar Disorder (2011) 0.7 0.7 1.1 1.0 -0.5
Body Mass Index (BMI) (2010) 0.0 0.1 0.1 0.2 0.3
Coronary Artery Disease (CAD) 0.3 0.3 0.6 -0.3 0.7
Crohns Disease (2012) 0.6 1.0 1.5 -1.2 0.6
Mean Putamen Volume 0.9 1.0 1.9 0.4 -1.4
Fasting Glucose 0.1 0.1 0.1 -0.3 0.1
HbA1C 2.3 2.5 4.0 2.0 -1.0
HDL Cholesterol 0.1 0.2 0.4 0.6 -0.2
LDL Cholesterol 0.5 0.8 1.5 1.2 0.1
Lupus 1.0 1.5 1.6 -1.1 1.3
Neuroticism (2016) 0.2 0.4 0.5 0.5 0.7
Primary Biliary Cirrhosis 1.0 1.4 2.8 -0.3 -1.7
Rheumatoid Arthritis 0.8 1.1 1.5 1.2 -0.9
Schizophrenia (2014) 0.3 0.6 0.6 0.8 -0.7
Triglycerides 0.2 0.3 0.4 0.5 0.7
Type 2 Diabetes (T2D) (2012) 3.0 3.4 5.5 -2.4 1.1
Ulcerative Colitis 0.0 0.0 0.0 0.2 0.1
Blood Eosinophil Count 0.1 0.6 0.9 -0.5 1.0
Blood Platelet Count 0.2 2.6 4.8 -2.2 0.5
Blood Red Count 0.2 1.6 2.6 -1.6 0.8
Blood White Count 0.8 5.8 11.6 -3.4 0.1
Heel T-Score 0.2 2.0 2.1 -1.5 1.3
BMI 0.9 5.1 6.4 -1.9 2.5
Height 1.3 24.9 37.6 6.1 -3.5
Waist Hip Ratio (WHR) 0.3 1.3 2.4 -1.6 0.3
Systolic Blood Pressure 1.9 9.6 10.8 -3.3 2.9
Smoking Status 0.0 0.1 0.1 0.2 0.3
Allergy or Eczema 3.4 8.9 13.0 3.6 -2.2
Cardiovascular Disease 1.0 3.4 5.5 -2.3 1.1
Hypothyroidism (self reported) 0.0 0.1 0.2 0.1 0.4
Respiratory disease 1.4 3.2 5.9 2.4 -0.6
Type 2 Diabetes (T2D) (2018) 1.0 1.9 2.7 -1.6 1.0
Lung FEV1/FVC ratio 2.3 11.4 15.2 -3.9 2.8
Lung FVC 0.9 4.6 4.8 2.1 -2.2
Neuroticism 1.5 3.7 5.1 2.3 -1.5
Chronotype (morning person) 0.3 0.7 0.7 0.8 0.8
Hair Pigment 0.0 0.9 1.5 -1.2 -0.6
Tanning 0.1 0.6 0.9 -0.6 -1.0
Hand grip strength (left) 0.7 1.9 3.1 0.9 -1.8
Number of treatments/medications taken 4.5 8.0 8.4 -2.9 2.8
Average weekly spirits intake 0.0 0.0 0.1 0.2 0.2
Sensitivity / hurt feelings 1.1 1.9 3.4 1.9 -0.5
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.1 -0.3 0.2
Hearing difficulty/problems: Yes 0.2 0.2 0.5 -0.7 0.1
Relative age of first facial hair 0.6 1.3 1.7 1.3 -0.9
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.2 1.1 0.7
Ever used hormone-replacement therapy (HRT) 0.4 0.4 0.9 0.2 -0.9
Ever had hysterectomy (womb removed) 0.2 0.3 0.4 -0.3 -0.6
Systolic blood pressure, automated reading 2.2 6.4 6.5 -2.5 2.5
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.2 -0.5 -0.3
Angina 0.6 0.7 1.3 -1.2 0.4
Medication for hormone replacement therapy 0.3 0.4 0.4 -0.6 -0.6
Vitamin and mineral supplements 0.0 0.1 0.1 0.3 -0.1
Supplements: Zinc 0.5 0.5 1.0 0.3 -1.0
Medication: Co-codamol 3.7 4.2 8.2 -2.9 0.5
Medication: Metformin 0.8 1.1 1.4 -0.9 1.2
Diabetes (father) 0.9 1.1 1.5 0.9 -1.2
Diabetes (mother) 2.7 3.5 5.1 -1.4 2.3
Severe depression (siblings) 3.6 4.1 5.7 2.4 -1.5
Pack years adult smoking proportion 0.1 0.1 0.3 -0.5 0.1
Impedance of leg (right) 0.7 3.2 5.5 0.9 -2.3
Leg fat-free mass (left) 0.1 0.5 0.6 0.8 0.6
Trunk fat percentage 0.1 0.5 0.6 -0.6 0.7
Hand grip strength (right) 0.0 0.1 0.2 -0.3 -0.4
Townsend deprivation index at recruitment 0.8 1.1 2.2 -0.3 1.5
Current tobacco smoking 0.3 0.4 0.8 -0.2 0.9
Average weekly fortified wine intake 0.7 0.8 1.0 1.0 0.7
Maternal smoking around birth 0.7 1.1 1.9 -1.4 0.5
Fed-up feelings 0.3 0.5 0.9 0.2 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.5 -0.7 0.6
Relative age voice broke 3.5 5.4 7.2 2.7 -1.9
Taking other prescription medications 1.1 1.8 2.9 -0.8 1.7
Age when periods started (menarche) 0.6 1.5 2.4 0.7 -1.6
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 0.6 -0.8 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.4 -0.6 0.6
Tinnitus: Yes, but not now, but have in the past 2.9 3.1 3.8 -2.0 1.5
Qualifications: CSEs or equivalent 3.0 4.0 4.6 -2.1 1.8
Serious illness, injury or assault to yourself 0.4 0.5 1.1 -1.0 -0.1
High blood pressure 3.1 8.7 10.4 -3.2 2.6
Hayfever, allergic rhinitis or eczema 2.8 6.1 8.7 3.0 -1.9
Multivitamins +/- minerals 0.5 0.7 0.8 -0.7 0.9
Stomach or abdominal pain in last month 0.1 0.2 0.2 -0.3 0.4
Supplements: Glucosamine 0.1 0.2 0.2 0.3 -0.5
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.5 -0.6 1.2
Medication: Atenolol 2.3 2.9 5.0 -0.9 2.2
Medication: Levothyroxine sodium 0.1 0.2 0.3 -0.6 0.2
Sitting height 1.3 9.2 14.4 3.8 -2.0
Chronic bronchitis/emphysema (father) 0.1 0.1 0.1 -0.2 -0.4
High blood pressure (mother) 0.7 1.0 1.1 -0.9 1.0
Body mass index (BMI) 1.4 6.0 9.2 -1.7 3.0
Impedance of leg (left) 0.7 3.5 5.5 1.2 -2.3
Leg predicted mass (left) 0.1 0.5 0.5 0.7 0.6
Trunk fat mass 0.1 0.6 1.1 -0.2 1.0
Waist circumference 0.8 2.8 5.1 -0.7 2.3
Number of incorrect matches in round 0.1 0.2 0.3 0.6 -0.0
Past tobacco smoking 0.5 1.0 1.7 -1.3 0.5
Alcohol usually taken with meals 1.2 1.9 3.9 0.0 -2.0
Nervous feelings 0.8 1.5 2.9 1.7 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 0.8 -0.7 0.9
Hearing difficulty/problems with background noise 0.2 0.4 0.7 0.4 0.8
Hair/balding pattern: Pattern 2 0.5 0.6 0.7 -0.8 -0.7
Had menopause 0.0 0.0 0.0 0.2 -0.0
Had other major operations 0.6 0.8 1.2 1.1 -0.6
Forced vital capacity (FVC) 2.0 7.5 9.1 2.4 -3.0
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 1.0 -1.0 1.0
Ever unenthusiastic/disinterested for a whole week 1.9 2.4 4.7 -0.1 -2.2
Qualifications: None of the above 1.2 2.6 3.3 -1.4 1.8
Financial difficulties in last 2 years 2.5 3.3 5.9 -0.9 2.4
Mouth/teeth dental problems 1.3 1.9 3.1 0.9 -1.8
Heart attack 0.6 0.8 0.8 -0.9 -0.9
Allergy 1.6 3.7 6.0 -2.4 1.2
Pain all over the body in last month 1.1 1.2 1.9 -0.7 1.4
Diabetes (self-reported) 1.0 1.6 1.8 -1.2 1.3
Hayfever/allergic rhinitis (self-reported) 3.2 4.2 7.1 2.7 -1.2
Medication: Ramipril 2.6 3.4 5.6 -2.4 1.1
Medication: Simvastatin 2.7 4.0 6.9 -2.6 1.1
Fluid intelligence score 0.3 0.6 1.1 1.1 -0.4
Illnesses of siblings 0.6 0.8 1.1 1.1 -0.6
Neuroticism score 1.5 3.2 5.3 2.3 -1.0
Weight 0.2 1.1 2.1 0.5 1.4
Impedance of arm (right) 0.8 3.6 6.5 0.8 -2.5
Arm fat percentage (right) 1.1 4.2 5.1 -1.8 2.2
Trunk fat-free mass 0.4 2.1 4.1 2.0 0.3
Hip circumference 0.4 1.7 3.2 0.4 1.8
Time employed in main current job 1.0 1.1 1.2 1.1 -1.0
Alcohol intake versus 10 years previously 0.5 0.7 1.3 -1.1 0.3
Father’s age at death 0.8 1.1 1.7 0.7 -1.3
Worrier / anxious feelings 2.2 4.2 7.3 2.7 -1.0
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 2.6 -1.5 1.6
Falls in the last year 0.6 0.9 1.7 -0.2 1.3
Hair/balding pattern: Pattern 3 0.1 0.1 0.1 0.3 0.3
Number of live births 0.4 0.5 0.8 0.9 0.5
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 5.9 1.8 -2.4
Pulse rate 0.1 0.2 0.4 -0.7 0.1
Happiness 2.4 2.9 3.3 1.6 -1.8
Noisy workplace 0.3 0.4 0.6 -0.3 -0.8
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.7 0.9 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 0.8 0.7 -0.9
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 0.1 0.6
Asthma 0.8 1.5 2.4 1.5 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.3 -0.1 0.6
Medication: Cholesterol lowering 0.3 0.4 0.6 -0.8 0.5
Depression (self-reported) 0.5 0.6 1.0 0.4 -1.0
Medication: Lansoprazole 0.3 0.3 0.6 -0.3 0.8
Prospective memory result 0.2 0.3 0.4 -0.4 0.6
Lung cancer (father) 1.0 1.2 1.9 0.7 -1.4
Illnesses of mother 1.1 1.4 2.7 0.1 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.3 8.1 1.5 -2.9
Pulse wave Arterial Stiffness index 0.1 0.1 0.2 -0.0 0.4
Impedance of arm (left) 0.7 3.2 6.0 0.6 -2.5
Arm fat mass (right) 0.7 2.9 4.4 -1.2 2.1
Trunk predicted mass 0.3 2.0 3.8 2.0 0.4
Standing height 1.4 14.1 19.2 4.4 -3.0
Length of working week for main job 5.2 5.7 6.7 -2.6 2.2
Exposure to tobacco smoke at home 0.5 0.6 0.6 -0.7 -0.8
Breastfed as a baby 1.0 1.3 2.3 -1.5 0.5
Tense / ‘highly strung’ 0.4 0.7 1.4 0.1 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.4 0.7 -0.3
Hair/balding pattern: Pattern 4 0.0 0.1 0.1 -0.4 0.0
Birth weight of first child 2.1 3.8 6.4 1.1 -2.5
Peak expiratory flow (PEF) 0.4 0.9 1.5 0.4 -1.2
Pulse wave reflection index 0.0 0.0 0.1 -0.0 0.3
Ever highly irritable/argumentative for 2 days 1.2 1.4 1.7 1.3 -1.1
Loud music exposure frequency 1.3 1.4 2.3 -0.7 1.5
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.0 -0.2 -0.2
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 1.9 -0.6 1.4
Blood clot in the leg (DVT) 2.4 3.1 5.8 -2.4 0.6
Medication: Paracetamol 2.2 3.6 5.7 -1.2 2.4
Headache pain in last month 0.2 0.3 0.4 0.7 0.4
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 1.1 1.0 -1.0
Glaucoma (self-reported) 0.5 0.6 1.1 1.0 -0.4
Gout (self-reported) 1.0 1.4 1.5 1.2 -1.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.3 -0.0 -0.5
Medication: Amlodipine 6.5 9.1 14.2 -2.0 3.8
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.5 0.7 -0.1
Birth weight 2.6 5.7 11.4 -3.4 -0.4
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 0.2 0.3
High blood pressure (siblings) 1.6 2.3 3.3 -1.8 1.1
Forced vital capacity (FVC), Best measure 3.0 11.1 13.7 2.9 -3.7
Body fat percentage 0.4 1.6 1.9 -1.1 1.4
Leg fat percentage (right) 0.8 2.7 3.5 -1.4 1.9
Arm fat-free mass (right) 0.2 1.1 1.9 1.4 0.6
Exposure to tobacco smoke outside home 0.8 1.0 1.5 1.2 -0.7
Comparative body size at age 10 0.6 1.7 3.1 -0.6 1.8
Number of full brothers 0.2 0.3 0.5 -0.7 0.2
Worry too long after embarrassment 3.9 6.5 7.4 2.3 -2.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.5 0.7 -0.6
Wheeze or whistling in the chest in last year 0.4 0.7 1.4 -1.2 0.3
Number of children fathered 2.8 3.2 3.6 1.7 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 2.1 2.5 2.8 1.7 -1.5
Age at first live birth 0.9 1.5 2.3 0.9 -1.5
Pulse wave peak to peak time 0.3 0.3 0.6 0.3 -0.8
Health satisfaction 1.6 2.1 2.4 -1.3 1.5
Shortness of breath walking on level ground 1.0 1.2 1.3 -1.2 1.1
Qualifications: College or University degree 0.6 2.0 2.3 1.3 -1.5
Eye problems/disorders: None of the above 0.2 0.2 0.2 0.4 0.4
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.2 -0.7 1.1
Emphysema/chronic bronchitis 0.1 0.1 0.3 0.5 0.1
Medication for pain relief, constipation, heartburn 0.8 1.3 1.6 1.3 -1.0
Neck or shoulder pain in last month 0.0 0.0 0.1 -0.3 -0.1
Medication: Blood pressure 1.8 3.2 3.7 -1.7 1.9
Angina (self-reported) 0.4 0.5 1.0 -1.0 0.3
Migraine (self-reported) 0.3 0.4 0.8 0.1 0.9
Medication: Ibuprofen 0.7 0.9 0.9 -0.9 0.9
Medication: Allopurinol 0.3 0.4 0.9 -0.0 -0.9
Medication: Omeprazole 0.7 0.8 1.0 1.0 -0.8
Medication: Seretide 50 evohaler 0.9 1.1 1.7 0.7 1.3
Mean time to correctly identify matches 1.4 2.7 3.9 -2.0 1.2
Heart disease (mother) 2.9 3.6 5.9 -1.1 2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.2 2.7 3.0 -1.6 1.7
Whole body fat mass 0.3 1.1 2.1 -0.4 1.4
Leg fat mass (right) 0.6 2.3 3.5 -1.0 1.9
Arm predicted mass (right) 0.2 0.8 1.0 1.0 0.7
Pulse rate, automated reading 0.4 1.3 1.3 -1.1 1.1
Alcohol intake frequency. 0.2 0.4 0.6 -0.7 -0.4
Comparative height size at age 10 0.2 1.1 1.8 1.3 -0.7
Number of full sisters 0.8 1.0 1.9 -0.3 1.4
Suffer from ‘nerves’ 0.3 0.5 1.0 1.0 -0.3
Overall health rating 2.3 4.8 4.9 -2.2 2.2
Chest pain or discomfort 0.6 0.9 1.9 -0.0 1.4
Had major operations 0.6 0.7 1.2 -0.4 -1.1
Age at last live birth 0.1 0.2 0.3 -0.3 -0.5
Family relationship satisfaction 2.9 3.5 3.7 1.8 -1.9
Leg pain on walking 2.7 3.3 3.9 -2.0 1.7
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 2.7 -0.1 -1.7
Commuting to job workplace: Car/motor vehicle 1.7 2.0 2.2 -1.5 1.3
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.2 -0.4
Medication: Aspirin 1.6 2.1 4.0 -2.0 0.5
Supplements: Vitamin C 0.2 0.3 0.5 0.0 -0.7
Knee pain experienced in last month 0.3 0.4 0.8 -0.9 0.1
Hypertension (Self-reported) 3.1 8.6 9.8 -3.1 2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.7 0.8 -0.5
Illnesses of father: Heart disease 0.0 0.1 0.1 -0.3 0.1
Illnesses of siblings: Diabetes 0.3 0.3 0.6 0.8 0.2
Smoking status: Previous 0.1 0.1 0.2 0.3 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 1.7 1.3 -1.2
Whole body fat-free mass 0.2 1.4 2.6 1.6 0.5
Leg fat-free mass (right) 0.1 0.7 0.9 0.9 0.7
Arm fat percentage (left) 1.3 5.1 6.3 -2.0 2.5
Average weekly red wine intake 2.1 3.1 4.8 1.2 -2.2
Handedness (chirality/laterality): Left-handed 1.4 1.6 3.1 1.8 -0.4
Mood swings 0.4 0.7 1.3 1.2 -0.2
Loneliness, isolation 0.2 0.3 0.6 -0.8 -0.2
Long-standing illness, disability or infirmity 2.2 3.4 5.9 -0.9 2.4
Ever had bowel cancer screening 1.2 1.4 2.9 -1.7 0.0
Diabetes diagnosed by doctor 1.6 2.6 2.8 -1.7 1.6
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.1 4.0 -0.5 2.0
Friendships satisfaction 1.4 1.7 2.5 0.9 -1.6
Qualifications: nursing, teaching 0.3 0.5 0.7 0.9 -0.6
Commuting to job workplace: Walk 1.8 1.9 2.5 1.2 -1.6
Eye problems/disorders: Cataract 0.5 0.5 0.7 -0.8 0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.3 -0.6 0.5
Medication for cholesterol 3.4 5.1 9.4 3.1 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 1.7 -0.6 1.3
Back pain experienced in last month 1.6 2.4 3.2 -1.2 1.8
Mineral and other dietary supplements 0.1 0.1 0.2 -0.5 -0.1
Breast cancer (self-reported) 0.0 0.0 0.0 0.1 0.2
Asthma (self-reported) 0.7 1.5 1.7 1.3 1.1
Osteoporosis (self-reported) 0.4 0.5 0.6 -0.8 -0.6
Osteoarthritis (self-reported) 0.5 0.7 1.3 -1.1 0.3
Medication: Aspirin 1.8 2.4 4.0 -2.0 0.9
Medication: Gliclazide 0.8 0.9 1.5 0.6 1.2
Illnesses of father: None of the above (group 1) 0.0 0.1 0.1 0.3 -0.0
Smoking status: Current 0.2 0.2 0.5 0.0 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.4 1.9 -0.9 -1.4
Whole body water mass 0.2 1.4 2.5 1.6 0.5
Leg predicted mass (right) 0.1 0.7 0.9 1.0 0.7
Arm fat mass (left) 0.9 3.8 5.7 -1.4 2.4
Number of self-reported non-cancer illnesses 0.2 0.4 0.8 0.0 0.9
Average weekly champagne plus white wine intake 0.1 0.2 0.2 0.4 0.4
Miserableness 0.0 0.0 0.0 -0.2 0.1
Guilty feelings 0.8 1.2 2.0 1.4 -0.7
Wears glasses or contact lenses 0.5 0.6 0.8 -0.6 0.9
Ever taken oral contraceptive pill 0.3 0.4 0.6 -0.7 0.5
Hearing aid user 1.3 1.4 1.6 1.3 -1.1
Mother’s age at death 0.2 0.2 0.4 -0.3 -0.6
Financial situation satisfaction 0.3 0.3 0.6 0.1 0.8
Tinnitus: Yes, now most or all of the time 0.9 1.0 1.8 -1.4 0.5
Commuting to job workplace: Public transport 0.2 0.2 0.3 0.6 0.4
Eye problems/disorders: Glaucoma 0.4 0.5 0.6 0.8 -0.5
Medication: Blood pressure 3.6 6.9 9.8 -3.1 2.0
Pain type(s) experienced in last month: Hip pain 0.8 1.1 1.1 -1.0 1.1
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.2 0.2 -0.5
High cholesterol (Self-reported) 1.8 3.2 3.4 -1.9 1.7
Medication: Bendroflumethiazide 1.5 2.3 2.8 -1.7 1.3
Medication: Paracetamol 2.4 3.7 5.9 -1.2 2.4
Medication: Lisinopril 0.1 0.1 0.2 -0.5 0.0
Medication: Atorvastatin 0.1 0.1 0.1 -0.3 0.2
Illnesses of father: High blood pressure 1.0 1.2 2.2 -1.5 0.5
Alcohol drinker status: Never 0.8 1.0 1.7 0.5 -1.3
Ever smoked 0.7 1.2 2.5 1.6 -0.1
Basal metabolic rate 0.2 1.1 1.6 1.3 0.8
Leg fat percentage (left) 0.7 2.6 3.4 -1.3 1.9
Arm fat-free mass (left) 0.2 1.1 1.7 1.3 0.7
Number of operations (self-reported) 0.1 0.2 0.4 0.6 -0.2
Average weekly beer plus cider intake 0.2 0.3 0.4 -0.6 0.4
Irritability 5.3 9.0 13.7 3.7 -2.1
Risk taking 0.0 0.1 0.1 0.2 -0.3
Ever had prostate specific antigen (PSA) test 0.8 1.0 1.9 -0.2 -1.4
Fractured/broken bones in last 5 years 0.1 0.2 0.2 0.5 0.4
Age started oral contraceptive pill 1.1 1.4 2.8 -0.1 -1.7
Diastolic blood pressure, automated reading 2.9 9.1 9.5 -2.9 3.1
Ever depressed for a whole week 3.8 4.6 7.0 1.5 -2.7
Unable to work because of sickness or disability 3.9 5.0 5.3 -2.2 2.3
Commuting to job workplace: Cycle 0.6 0.7 1.3 0.1 1.1
Myopia 0.1 0.2 0.3 -0.5 -0.3
Vascular/heart problems diagnosed by doctor 2.8 7.5 11.5 3.4 -1.9
Cholesterol lowering medication 1.8 2.7 4.8 -2.2 0.8
Medication: Omeprazole (e.g. Zanprol) 1.7 2.1 2.4 1.6 -1.3
Pain experienced in last month 1.8 2.9 3.2 1.6 -1.8
Supplements: Calcium 0.2 0.2 0.3 0.4 -0.5
Basal cell carcinoma (self-reported) 4.0 4.7 6.1 2.5 -1.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.2 -0.6 -1.1
Deep venous thrombosis (DVT) (self-reported) 1.9 2.4 4.5 -2.1 0.5
Heart disease (siblings) 0.2 0.3 0.5 -0.7 0.3
Alcohol drinker status: Previous 0.5 0.5 0.8 -0.9 -0.5
Pack years of smoking 0.2 0.2 0.5 -0.7 0.1
Impedance of whole body 0.8 4.1 7.7 0.7 -2.8
Leg fat mass (left) 0.5 2.1 3.6 -0.8 1.9
Arm predicted mass (left) 0.3 1.3 2.3 1.5 0.6