TWAS hub - FIBCD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0326	0.0151	2.0e-03	0.013	0.009	0.011	NA	0.016	0.00071	4.0e-03	0.00170	NA	0.00020
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0434	0.0186	1.5e-03	0.009	0.016	0.006	NA	0.011	0.03000	5.2e-03	0.06300	NA	0.01700
3	TCGA	Pancreatic Adenocarcinoma	0.2660	0.0940	1.6e-03	0.015	0.051	0.020	NA	0.025	0.07600	3.5e-03	0.04800	NA	0.03000
4	TCGA	Prostate Adenocarcinoma	0.0468	0.0237	6.4e-03	0.002	0.019	0.012	NA	0.000	0.20000	3.6e-03	0.01800	NA	0.33000
5	TCGA	Thyroid Carcinoma	0.0680	0.0270	2.3e-05	0.021	0.049	0.036	NA	0.028	0.00380	1.4e-05	0.00019	NA	0.00085

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Alcohol intake frequency.	4.1	9.5	21.3	2.0	4.2	4.6	-1.1	1.7
Illness, injury, bereavement, stress in last 2 years	4.1	5.0	12.9	-0.6	-2.4	-1.9	1.6	-3.6
Tinnitus: Yes, but not now, but have in the past	3.9	4.2	12.3	0.2	1.4	3.5	-1.8	1.9
Hearing difficulty/problems with background noise	3.7	5.9	10.6	2.2	3.3	3.1	-0.3	2.1
Waist circumference	3.6	13.1	25.0	3.9	5.0	4.1	-1.1	2.7
Overall health rating	3.5	7.6	14.8	3.0	3.9	3.6	-0.5	1.1
Average weekly champagne plus white wine intake	3.5	4.8	13.6	-0.7	-2.7	-3.7	0.8	-1.4
Commuting to job workplace: Public transport	3.4	4.0	7.2	-2.4	-2.7	-0.7	-0.5	-2.5
Chronic bronchitis/emphysema (father)	3.3	3.9	12.0	2.2	-0.0	0.4	3.5	-1.6
Illnesses of father: High blood pressure	3.3	4.1	9.8	2.0	3.1	1.1	-0.7	2.2
BMI	3.1	18.2	39.8	4.5	6.3	3.9	-1.4	3.7
Medication: Allopurinol	3.1	4.1	7.7	2.3	-0.6	-2.8	2.1	-1.6
Medication: Levothyroxine sodium	2.9	5.0	7.2	0.4	2.6	2.7	-2.5	2.1
Frequency of tiredness / lethargy in last 2 weeks	2.9	4.8	11.9	1.9	3.5	2.7	0.8	0.3
Arm fat mass (right)	2.9	11.9	27.2	3.6	5.2	3.2	-0.4	2.9
Medication for pain relief, constipation, heartburn	2.9	5.0	16.2	-0.3	-2.5	-4.0	1.5	-0.6
Had major operations	2.9	3.4	8.7	0.7	2.2	0.6	-1.5	2.9
Alcohol intake versus 10 years previously	2.8	4.1	10.8	1.3	2.8	3.3	0.2	-0.3
Shortness of breath walking on level ground	2.8	3.3	8.7	1.7	2.9	1.1	-0.7	1.8
Leg fat mass (right)	2.8	10.7	23.7	2.9	4.9	3.8	-0.8	2.5
Body mass index (BMI)	2.7	11.4	24.9	3.0	5.0	3.6	-1.5	2.7
Happiness	2.7	3.3	9.1	1.3	2.1	3.0	-0.7	1.0
Blood clot in the leg (DVT)	2.7	3.4	8.9	2.2	1.7	3.0	0.8	0.3
Arm fat mass (left)	2.6	10.9	25.7	3.4	5.1	3.3	-0.3	2.4
Deep venous thrombosis (DVT) (self-reported)	2.6	3.4	7.1	2.3	1.8	2.7	1.1	0.4
Leg fat mass (left)	2.6	10.3	24.0	2.8	4.9	3.5	-0.8	2.7
Diabetes (mother)	2.5	3.2	7.2	1.1	2.6	2.7	-0.2	0.8
Lung cancer (father)	2.5	3.0	8.7	-1.2	-1.1	-0.9	3.0	-1.6
Average weekly red wine intake	2.5	3.6	6.5	-2.6	-2.5	-2.0	-0.7	-0.9
Hearing difficulty/problems: Yes	2.4	3.7	10.0	3.2	2.2	1.5	0.8	0.8
Alcohol usually taken with meals	2.4	3.9	9.4	-1.3	-3.1	-0.8	1.0	-2.6
Pain experienced in last month	2.4	4.0	11.1	-0.1	-2.3	-3.3	0.6	-1.8
Townsend deprivation index at recruitment	2.3	3.2	8.1	1.4	1.6	2.9	-1.0	1.5
Arm fat percentage (right)	2.3	9.1	21.9	3.4	4.7	2.6	-0.4	2.3
Body fat percentage	2.3	9.0	22.5	3.0	4.7	2.6	-0.5	2.5
Mouth/teeth dental problems: Loose teeth	2.3	2.8	6.6	1.7	1.3	2.6	0.4	-1.6
Whole body fat mass	2.3	9.8	22.8	3.3	4.8	3.0	-0.2	2.5
Leg pain on walking	2.3	2.9	7.9	-0.3	2.8	1.5	-1.0	1.8
Tinnitus: Yes, now most or all of the time	2.3	2.7	4.4	0.2	-2.1	-1.4	1.6	-2.1
Ever had prostate specific antigen (PSA) test	2.3	2.7	6.2	-0.9	-2.2	-1.3	-0.3	-2.5
Trunk fat mass	2.2	9.3	22.5	3.4	4.7	2.6	-0.2	2.4
Gout (self-reported)	2.2	3.1	5.9	1.0	-1.5	-2.4	1.8	-1.7
Leg fat percentage (right)	2.2	7.9	17.9	2.5	4.2	3.1	-0.6	2.2
Arm fat percentage (left)	2.2	8.6	20.9	3.3	4.6	2.8	-0.3	1.9
Supplements: Glucosamine	2.1	2.7	7.4	1.1	2.7	0.3	-0.2	2.2
Weight	2.1	10.2	22.8	3.5	4.8	3.1	-0.1	2.6
Headache pain in last month	2.1	3.7	7.0	1.5	2.6	2.6	0.5	1.5
Hypertension (Self-reported)	2.1	5.7	7.9	1.2	2.8	2.6	-2.3	2.7
Leg fat percentage (left)	2.1	7.5	19.3	2.3	4.4	2.6	-0.8	2.4
Number of operations (self-reported)	2.1	3.2	7.4	1.0	2.7	0.1	-0.1	2.7
Trunk fat percentage	2.0	8.1	21.0	3.0	4.6	2.3	-0.4	2.4
Alzheimer’s Disease (in father)	1.9	2.0	3.3	1.1	1.5	-1.8	1.8	0.7
High blood pressure	1.9	5.2	6.8	0.8	2.5	2.5	-2.6	2.5
Medication: Paracetamol	1.9	3.1	10.8	0.5	2.0	3.3	-0.6	0.3
High blood pressure (siblings)	1.9	2.7	6.2	0.8	2.5	1.9	-0.9	1.6
Exposure to tobacco smoke outside home	1.9	2.6	4.3	1.7	2.1	1.8	1.4	0.6
Medication: Aspirin	1.9	2.4	4.7	1.2	2.2	2.1	-1.2	0.5
Illnesses of siblings: Diabetes	1.9	2.4	3.9	1.4	2.0	1.6	-0.7	1.7
Diastolic blood pressure, automated reading	1.9	5.8	13.2	2.7	3.6	2.0	-0.9	2.0
Vitamin and mineral supplements	1.8	2.5	6.8	-0.8	-2.0	-2.6	-0.2	-0.9
Alcohol drinker status: Never	1.8	2.1	4.3	1.7	2.1	-0.3	0.0	1.8
Medication: Ventolin 100micrograms inhaler	1.7	2.2	3.8	-1.3	-1.4	1.5	-2.0	-0.9
Number of children fathered	1.7	2.0	4.8	-1.4	-2.2	-1.6	-0.2	-0.6
Long-standing illness, disability or infirmity	1.7	2.7	6.6	0.7	2.0	2.6	-1.2	0.9
Unable to work because of sickness or disability	1.7	2.3	4.4	0.8	1.4	2.1	-1.3	1.6
Serious illness, injury or assault to yourself	1.6	2.0	3.7	1.2	1.9	0.7	-0.8	1.9
Father’s age at death	1.6	2.1	5.4	-0.7	-2.1	-2.3	0.1	-0.3
Loneliness, isolation	1.6	2.3	5.1	1.6	1.5	2.3	-0.4	1.2
Age at First Birth	1.5	2.2	5.5	-0.8	-2.4	-1.2	1.3	-1.3
Ever used hormone-replacement therapy (HRT)	1.5	1.8	6.9	-2.6	-0.0	0.7	-1.1	-0.7
Hair/balding pattern: Pattern 3	1.5	2.2	4.3	-1.6	-2.1	-0.1	-0.9	-1.8
Pulse wave reflection index	1.5	1.8	4.4	1.3	-0.6	0.7	1.5	-2.1
Age at first live birth	1.5	2.7	6.6	0.6	-1.7	-2.6	1.6	-1.0
Number of full sisters	1.5	1.9	2.6	-1.4	1.2	1.6	-1.6	0.8
Family relationship satisfaction	1.5	1.8	3.8	1.9	1.2	1.2	1.3	-0.6
Friendships satisfaction	1.5	1.9	5.3	1.4	0.9	-1.0	2.3	-0.5
Miserableness	1.5	2.6	6.0	1.6	2.5	0.7	1.9	0.8
Hair/balding pattern: Pattern 2	1.4	1.8	3.5	1.1	1.7	1.3	0.1	1.9
Hip circumference	1.4	6.1	12.3	3.0	3.5	2.2	0.0	2.2
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	6.7	1.7	0.6	0.5	2.6	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	5.6	-0.8	0.2	-2.4	-1.1	0.6
Handedness (chirality/laterality): Left-handed	1.4	1.7	2.9	-1.5	-1.7	-1.7	-0.3	0.7
Back pain experienced in last month	1.4	2.0	6.9	-0.0	1.0	2.6	0.7	-1.3
Number of self-reported non-cancer illnesses	1.4	2.4	3.4	1.4	1.9	1.2	-1.5	1.7
Risk taking	1.4	2.1	5.1	0.3	2.2	1.5	-0.8	1.5
Cardiovascular Disease	1.3	4.4	10.3	1.5	3.2	1.9	-0.8	2.4
Average weekly spirits intake	1.3	1.6	4.2	-2.0	-1.2	-0.3	-1.1	1.1
Frequency of depressed mood in last 2 weeks	1.3	1.9	5.3	0.9	1.7	2.3	0.1	0.3
Prospective memory result	1.3	1.6	5.5	-1.4	0.1	0.8	-2.3	0.4
Medication: Ibuprofen	1.3	1.6	4.3	0.7	2.1	1.2	-1.0	0.8
Supplements: Vitamin C	1.3	1.5	3.4	1.2	-0.1	1.1	1.2	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	4.4	1.9	1.8	1.4	0.5	2.1
Medication: Paracetamol	1.3	2.0	6.3	0.8	1.7	2.5	-0.3	0.4
Age started oral contraceptive pill	1.3	1.6	4.6	-2.1	-1.3	-0.8	-0.5	-0.9
Vascular/heart problems diagnosed by doctor	1.3	3.6	4.9	-0.6	-2.1	-2.2	2.0	-2.0
Verbal and Numeric Reasoning (VNR)	1.2	3.0	6.4	-0.9	-2.5	-1.1	1.5	-2.1
Number of treatments/medications taken	1.2	2.2	3.5	1.4	1.9	1.7	-1.4	0.8
Had other major operations	1.2	1.4	4.0	-0.6	1.6	0.0	-0.4	2.0
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	4.2	0.1	1.6	2.0	-0.2	0.8
Mouth/teeth dental problems	1.2	1.9	5.3	-0.7	-1.7	-2.3	-0.2	0.6
Illnesses of siblings	1.2	1.7	3.1	-0.8	-1.8	-1.8	1.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.1	1.3	1.3	0.1	1.3	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	4.0	0.6	2.0	1.7	-0.5	-0.1
Exposure to tobacco smoke at home	1.2	1.3	3.0	1.0	1.7	0.7	-0.5	1.4
Pulse wave peak to peak time	1.2	1.4	3.9	-1.1	-2.0	-0.9	-0.1	-1.0
Health satisfaction	1.2	1.6	3.5	1.2	1.9	0.4	0.1	1.7
Neck or shoulder pain in last month	1.2	1.8	3.7	-0.5	1.0	1.9	-1.6	1.2
Medication: Blood pressure	1.2	2.1	4.0	1.6	1.6	-0.0	-1.1	2.0
Age at last live birth	1.2	1.7	4.7	-0.4	-1.7	-2.2	0.7	-0.6
Eye problems/disorders: Cataract	1.2	1.4	2.0	1.4	1.4	-1.4	1.0	-0.3
Medication: Aspirin	1.2	1.6	2.8	1.1	1.7	1.7	-1.0	0.4
Medication: Lisinopril	1.2	1.6	2.9	0.6	1.7	0.7	-1.2	1.6
Cholesterol lowering medication	1.2	1.7	3.2	0.4	1.6	1.6	-1.8	0.5
Supplements: Zinc	1.1	1.2	4.0	-0.1	-0.9	0.9	0.7	-2.0
Multivitamins +/- minerals	1.1	1.3	3.5	0.6	1.4	1.9	0.5	0.7
Medication: Ramipril	1.1	1.4	4.1	2.0	1.1	-0.1	-0.2	1.2
Noisy workplace	1.1	1.4	5.2	0.2	0.9	2.3	0.1	-1.0
Pulse wave Arterial Stiffness index	1.1	1.3	3.5	1.0	1.9	0.9	0.3	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.6	1.1	1.1	-1.6	0.8	1.0
Suffer from ‘nerves’	1.1	1.7	3.5	1.0	1.8	0.9	-0.6	1.9
Ever had bowel cancer screening	1.1	1.3	4.0	-0.8	-1.4	0.1	0.2	-2.0
Alzheimer’s Disease (including proxy)	1.0	1.5	2.1	1.3	1.4	-1.2	1.4	0.3
Blood Red Count	1.0	10.0	16.7	2.5	4.1	3.9	-2.2	2.6
Respiratory disease	1.0	2.3	6.5	0.8	2.6	1.3	-1.0	1.2
Systolic blood pressure, automated reading	1.0	3.0	6.4	0.5	2.1	1.3	-1.5	2.5
Medication: Co-codamol	1.0	1.2	2.8	0.9	0.5	1.7	0.5	-1.2
Pain all over the body in last month	1.0	1.1	2.9	1.5	0.3	1.7	0.3	-0.3
Eye problems/disorders: None of the above	1.0	1.2	2.4	0.7	0.9	1.5	-0.2	1.5
Heart attack/myocardial infarction (self-reported)	1.0	1.4	2.8	1.7	1.6	0.4	1.0	0.3
Bipolar Disorder (2018)	0.9	1.4	5.2	0.0	0.1	-2.3	1.4	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	3.4	0.0	1.8	1.3	-0.3	0.9
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.8	0.0	1.9	0.5	0.8	0.5
Age when periods started (menarche)	0.9	2.1	4.1	-1.7	-1.1	1.4	-2.0	0.1
Medication: Atenolol	0.9	1.1	2.3	0.7	1.3	1.5	-1.1	0.1
Heart attack	0.9	1.2	2.8	1.5	1.7	0.2	0.9	0.4
Allergy	0.9	2.0	3.9	-1.8	-1.5	-2.0	0.1	-0.5
Medication: Simvastatin	0.9	1.4	5.1	-0.3	1.1	0.6	-2.3	0.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.2	-1.5	-1.1	0.3	1.3	-1.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.6	0.1	1.4	1.1	-1.5	1.9
Medication: Seretide 50 evohaler	0.9	1.0	2.9	0.5	-0.3	1.2	0.6	-1.7
Knee pain experienced in last month	0.9	1.3	2.8	-1.7	1.3	1.1	-0.7	0.7
Mood swings	0.9	1.7	6.6	-0.3	1.2	2.6	-0.4	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.7	0.8	1.0	0.6	-1.2	1.3
Mineral and other dietary supplements	0.9	1.3	3.9	-0.8	-2.0	-1.2	-0.4	-0.5
Medication: Blood pressure	0.9	1.7	4.0	-0.2	1.1	2.0	-1.7	0.7
Arm fat-free mass (left)	0.9	4.7	9.8	2.1	3.1	2.3	-0.1	2.0
Schizophrenia (2018)	0.8	1.7	4.9	0.0	1.4	2.2	0.1	1.2
Relative age voice broke	0.8	1.3	2.8	-1.2	-1.0	0.7	-1.7	-0.8
High blood pressure (mother)	0.8	1.1	3.8	0.7	2.0	-0.6	0.8	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.5	1.3	1.6	0.4	1.1	1.0
Forced vital capacity (FVC)	0.8	3.1	6.3	-0.4	-1.7	-2.1	2.5	-1.3
Financial difficulties in last 2 years	0.8	1.1	2.2	-0.6	0.3	1.0	-1.3	1.5
Neuroticism score	0.8	1.7	3.4	1.2	1.5	1.8	1.3	0.2
Medication: Cholesterol lowering	0.8	1.2	4.5	-0.3	0.3	-0.2	-2.1	1.1
Illnesses of mother	0.8	1.0	2.7	-1.6	-0.9	-0.1	-0.8	1.0
Migraine (self-reported)	0.8	1.0	1.8	-0.6	0.0	1.3	-1.3	-0.9
Mean time to correctly identify matches	0.8	1.5	3.6	-1.9	-0.7	-1.3	-0.9	1.0
Heart disease (mother)	0.8	0.9	2.1	0.1	1.1	1.4	-1.1	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.8	0.5	1.4	1.1	-0.3	1.2
Wears glasses or contact lenses	0.8	0.9	1.5	-1.1	-1.0	-1.2	-0.3	-0.9
Ever taken oral contraceptive pill	0.8	0.9	1.8	0.6	1.3	-1.1	1.0	0.3
High cholesterol (Self-reported)	0.8	1.5	2.9	0.8	1.7	0.7	-1.7	0.6
Medication: Bendroflumethiazide	0.8	1.2	4.0	-1.2	-0.5	-0.5	-2.0	0.2
Basal metabolic rate	0.8	4.4	8.8	2.4	3.0	2.2	0.1	1.5
Arm predicted mass (left)	0.8	3.9	8.4	1.8	2.9	2.0	-0.2	2.0
Lupus	0.7	1.1	3.9	-2.0	-0.4	0.0	-0.9	0.9
Blood White Count	0.7	5.0	8.2	2.9	2.8	1.5	0.3	2.6
Sensitivity / hurt feelings	0.7	1.2	4.8	0.8	0.5	0.3	2.2	-0.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.4	1.2	0.9	1.0	-0.6	0.4
Medication for hormone replacement therapy	0.7	0.8	3.4	-1.9	-0.3	-0.2	0.1	-0.5
Leg fat-free mass (left)	0.7	3.5	6.5	2.5	2.4	2.2	0.5	0.4
Maternal smoking around birth	0.7	1.0	2.9	0.2	1.3	-0.0	-0.7	1.7
Qualifications: None of the above	0.7	1.5	3.8	0.9	1.0	1.4	-1.9	0.3
Breastfed as a baby	0.7	0.8	2.5	-1.6	-0.7	-0.6	0.1	-0.9
Glaucoma (self-reported)	0.7	0.8	1.3	-1.0	-1.0	-0.9	-1.1	-0.1
Arm fat-free mass (right)	0.7	3.4	6.2	1.6	2.5	2.2	-0.4	1.7
Wheeze or whistling in the chest in last year	0.7	1.2	2.6	0.8	1.6	1.4	-0.8	0.6
Arm predicted mass (right)	0.7	3.4	6.5	1.7	2.6	2.2	-0.2	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.3	0.6	1.5	1.0	0.2	0.7
Illnesses of father: Heart disease	0.7	1.0	4.1	-0.7	0.5	0.5	-2.0	0.1
Smoking status: Previous	0.7	1.0	2.4	-0.4	0.1	-1.6	-1.3	0.9
Illnesses of father: None of the above (group 1)	0.7	0.9	2.6	-1.2	-1.6	-0.3	-0.2	-0.5
Smoking status: Current	0.7	1.2	2.5	1.0	1.6	0.8	0.3	1.2
Irritability	0.7	1.2	4.9	0.1	-0.0	2.2	-0.3	-0.9
Pack years of smoking	0.7	1.0	3.8	0.4	0.9	1.9	0.6	0.0
Breast Cancer	0.6	1.4	5.1	-0.4	0.5	2.3	-1.1	-0.8
Fasting Glucose	0.6	0.7	1.9	-1.1	-1.4	0.1	-0.0	-0.7
Schizophrenia (2014)	0.6	1.3	3.0	0.0	1.0	1.7	1.4	0.6
Systolic Blood Pressure	0.6	2.9	6.7	0.8	1.9	0.9	-1.7	2.6
Angina	0.6	0.7	2.3	-0.9	0.5	0.5	-1.5	0.2
Diabetes (father)	0.6	0.7	1.6	-1.1	-1.3	0.8	-0.1	-0.3
Pack years adult smoking proportion	0.6	1.0	2.0	0.7	1.2	1.4	0.9	0.4
Leg predicted mass (left)	0.6	3.3	6.2	2.5	2.4	2.1	0.5	0.4
Pulse rate	0.6	1.1	2.7	-0.2	1.5	-0.3	-0.3	1.7
Depression (self-reported)	0.6	0.8	1.6	-0.4	0.9	1.0	-1.3	0.4
Forced vital capacity (FVC), Best measure	0.6	2.3	4.7	0.1	-1.7	-1.5	2.2	-1.3
Comparative body size at age 10	0.6	1.6	3.3	1.1	1.7	-0.0	-0.7	1.8
Number of full brothers	0.6	0.8	2.4	-1.6	-0.4	-0.0	-0.5	-1.0
Worry too long after embarrassment	0.6	1.1	2.1	-0.5	-1.2	0.7	1.5	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.7	0.6	1.3	0.9	-0.8	1.3
Mother’s age at death	0.6	0.8	1.8	-1.1	-1.3	-0.5	-0.3	-0.8
Depressed Affect (Nagel 2018)	0.5	1.0	2.9	-0.0	1.7	1.0	-0.1	1.1
Depression (Nagel 2018)	0.5	0.7	1.9	-0.0	1.3	1.4	-0.2	-0.1
Neuroticism (2016)	0.5	0.7	1.4	1.1	0.4	1.2	0.7	-0.7
Ulcerative Colitis	0.5	0.8	2.8	0.0	-0.2	1.7	-0.2	-1.0
Hypothyroidism (self reported)	0.5	1.1	2.2	-0.2	1.2	1.4	-0.5	1.5
Neuroticism	0.5	1.2	3.7	0.5	1.9	1.1	0.7	0.3
Chronotype (morning person)	0.5	1.2	3.8	-1.9	-1.2	0.6	-0.3	-0.8
Relative age of first facial hair	0.5	1.0	2.8	-0.9	-0.7	-0.9	0.5	-1.7
Taking other prescription medications	0.5	0.8	1.4	0.3	1.1	0.9	-1.2	0.6
Time employed in main current job	0.5	0.6	1.9	-0.7	-0.5	-1.4	0.5	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.4	0.1	-1.1	-1.3	2.1	-0.4
Impedance of arm (left)	0.5	2.2	4.1	-0.2	-1.2	-1.9	2.0	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.5	0.8	1.2	0.1	1.1	0.7
Peak expiratory flow (PEF)	0.5	1.2	4.2	1.3	-0.4	0.1	2.1	0.2
Loud music exposure frequency	0.5	0.6	1.5	0.0	-0.1	-0.6	1.0	-1.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	-1.0	1.1	0.4	-0.5	0.6
Emphysema/chronic bronchitis	0.5	0.6	1.0	-0.7	-0.5	1.0	-1.0	0.7
Angina (self-reported)	0.5	0.7	2.4	-0.8	0.5	0.4	-1.6	0.1
Pulse rate, automated reading	0.5	1.7	3.1	1.4	1.8	1.2	-0.6	1.1
Chest pain or discomfort	0.5	0.7	1.3	1.1	-0.0	1.1	0.9	-0.4
Whole body fat-free mass	0.5	2.8	5.2	2.1	2.3	1.9	0.2	1.1
Leg fat-free mass (right)	0.5	2.7	5.3	2.2	2.3	1.8	0.5	0.5
Whole body water mass	0.5	2.8	5.4	2.0	2.3	1.8	0.2	1.2
Leg predicted mass (right)	0.5	2.5	5.2	2.1	2.3	1.7	0.4	0.5
Guilty feelings	0.5	0.7	1.4	-1.1	-0.0	1.2	0.5	-0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.4	0.4	1.2	0.8	0.8	0.5
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.2	-1.3	-0.7	0.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.0	0.5	0.3	0.8	-0.9	1.0
Alcohol drinker status: Previous	0.5	0.5	1.2	-1.1	-0.7	0.8	0.2	-0.6
Schizophrenia vs Biploar Disorder	0.4	0.6	2.8	0.0	0.0	0.0	0.0	1.7
Reaction Time	0.4	0.8	1.6	-0.9	0.0	-1.3	-0.4	1.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	0.9	1.2	0.8	-0.8	0.5
Hand grip strength (left)	0.4	1.1	2.3	1.1	-0.6	-0.1	1.5	-1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	0.7	0.2	0.6	0.5	-1.0
Medication: Metformin	0.4	0.5	1.2	0.1	1.0	-0.2	-1.1	0.6
Hand grip strength (right)	0.4	1.0	1.4	1.2	-0.3	1.0	1.1	-1.0
Current tobacco smoking	0.4	0.6	1.4	0.4	1.2	0.6	0.3	0.9
Fed-up feelings	0.4	0.7	2.2	0.3	0.9	1.5	-0.2	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.5	-0.3	-0.0	-0.4	1.6	-1.3
Qualifications: CSEs or equivalent	0.4	0.5	0.8	-0.3	0.8	-0.3	0.9	0.9
Stomach or abdominal pain in last month	0.4	0.5	1.9	0.5	-0.0	1.4	-0.4	-0.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	0.1	-0.1	-0.0	1.2	-0.9
Past tobacco smoking	0.4	0.8	1.6	-0.4	-1.1	0.6	0.9	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.1	-0.6	-0.1	-0.4	1.8	-1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.3	0.6	0.2	-0.5	1.5	-0.1
Impedance of arm (right)	0.4	1.9	4.3	0.3	-0.8	-1.7	2.1	-1.1
Trunk fat-free mass	0.4	2.1	3.5	1.7	1.9	1.6	0.0	1.3
Number of live births	0.4	0.5	1.3	-0.6	-0.3	-0.3	-1.1	0.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	4.7	0.0	-1.1	-1.2	2.2	-0.2
Trunk predicted mass	0.4	2.2	3.6	1.7	1.9	1.6	0.0	1.3
Tense / ‘highly strung’	0.4	0.6	1.2	1.1	0.9	0.6	0.5	0.7
Hair/balding pattern: Pattern 4	0.4	1.0	1.6	-0.6	-1.0	0.8	-1.2	-1.3
Birth weight	0.4	0.9	2.5	-0.2	-1.6	-1.1	0.8	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	0.8	0.9	1.0	0.3	0.2
Comparative height size at age 10	0.4	2.5	6.1	2.2	0.7	-0.8	2.5	-0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.5	0.0	0.6	-0.6	1.2	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	0.3	0.5	0.5	-1.2	0.5
Qualifications: nursing, teaching	0.4	0.6	1.1	1.1	0.9	0.1	1.0	0.3
Commuting to job workplace: Walk	0.4	0.4	0.7	0.5	0.6	0.7	-0.4	-0.8
Breast cancer (self-reported)	0.4	0.4	1.9	-0.1	0.1	0.2	-0.5	1.4
Osteoporosis (self-reported)	0.4	0.5	1.4	-1.2	-0.4	-0.0	0.3	-0.9
Osteoarthritis (self-reported)	0.4	0.5	1.9	-0.3	0.4	1.4	0.3	0.1
Medication: Gliclazide	0.4	0.5	1.2	-0.3	0.6	1.1	-0.9	0.2
Hearing aid user	0.4	0.5	1.7	1.3	0.2	0.6	-0.5	0.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.5	-0.3	-1.2	-0.6	-0.1	-0.8
Average weekly beer plus cider intake	0.4	0.5	2.1	0.1	0.5	-0.4	1.5	0.4
Heart disease (siblings)	0.4	0.4	1.6	1.3	0.1	0.3	-0.3	-0.7
Crohns Disease (2012)	0.3	0.6	1.4	0.6	-0.0	-0.8	1.2	-0.7
HbA1C	0.3	0.3	0.9	-0.5	-0.0	0.9	-0.7	-0.4
Rheumatoid Arthritis	0.3	0.4	0.8	0.4	-0.4	0.3	0.8	-0.9
Triglycerides	0.3	0.5	1.6	-0.3	0.8	1.3	-0.4	0.3
Waist Hip Ratio (WHR)	0.3	1.2	2.8	1.4	1.3	1.7	-0.1	-0.0
Smoking Status	0.3	0.8	1.6	0.8	1.2	-0.4	0.2	1.3
Lung FEV1/FVC ratio	0.3	1.5	2.2	1.0	1.5	1.5	-0.4	1.4
Lung FVC	0.3	1.7	4.6	-1.3	-2.1	-1.1	0.8	-0.8
Severe depression (siblings)	0.3	0.4	1.6	-0.0	0.1	0.0	1.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.4	0.4	0.5	1.2	-0.1	-0.2
Impedance of leg (left)	0.3	1.4	3.1	-1.6	-0.6	-1.8	0.2	0.9
Nervous feelings	0.3	0.6	1.6	1.3	0.5	0.5	0.8	-0.4
Diabetes (self-reported)	0.3	0.4	0.9	0.7	0.9	-0.1	-0.9	-0.1
Falls in the last year	0.3	0.4	1.3	-1.1	0.5	0.5	0.0	0.1
Medication: Lansoprazole	0.3	0.3	1.2	0.7	-0.3	-0.0	0.0	1.1
Qualifications: College or University degree	0.3	0.9	2.1	0.4	-1.4	-1.2	0.6	-0.3
Medication for cholesterol	0.3	0.5	1.3	0.7	-0.4	-1.1	0.8	-0.1
Financial situation satisfaction	0.3	0.4	1.4	0.6	0.4	0.3	0.3	1.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	0.6	0.7	0.1	0.9	0.5
Ever smoked	0.3	0.6	1.5	0.3	0.2	-0.7	-0.9	1.2
Myopia	0.3	0.4	0.8	0.1	-0.4	-0.6	0.7	-0.9
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	0.5	0.9	0.4	0.5	0.3
Impedance of whole body	0.3	1.5	3.6	-1.0	-1.1	-1.9	1.2	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.6	1.1	0.0	1.0	0.2	1.0	0.9
Alzheimer’s Disease (in mother)	0.2	0.3	1.1	1.0	0.2	-0.1	-0.0	-0.6
Irritable Bowel Disease (IBD)	0.2	0.5	1.8	0.1	0.1	-0.0	0.9	-1.3
Ulcerative Colitis (UC)	0.2	0.3	0.6	-0.7	0.3	0.5	0.3	-0.7
Mean Putamen Volume	0.2	0.2	0.5	-0.2	0.4	0.3	-0.7	0.6
HDL Cholesterol	0.2	0.3	0.6	-0.7	-0.4	-0.5	-0.8	0.3
Heel T-Score	0.2	1.5	2.9	-0.2	-0.8	-1.4	1.7	-1.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	-0.6	0.5	0.6	-0.6	-0.0
Impedance of leg (right)	0.2	0.9	1.7	-1.1	-1.0	-1.3	0.5	0.4
Average weekly fortified wine intake	0.2	0.3	0.6	0.2	0.5	-0.3	0.8	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	-0.3	0.4	0.3	0.5	-1.0
Sitting height	0.2	1.5	3.5	1.3	0.9	-0.3	1.9	1.2
Number of incorrect matches in round	0.2	0.4	0.8	-0.7	-0.9	-0.5	0.4	0.3
Had menopause	0.2	0.3	0.7	-0.2	0.7	0.2	-0.4	0.8
Fluid intelligence score	0.2	0.5	1.7	0.2	-0.6	-0.6	1.3	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.4	0.7	0.5	0.6	-0.3
Asthma	0.2	0.4	1.1	0.8	1.1	-0.1	-0.4	0.6
Standing height	0.2	1.7	6.2	1.1	-0.1	-1.0	2.5	0.0
Length of working week for main job	0.2	0.2	0.3	0.4	-0.0	-0.6	0.4	-0.5
Medication: Amlodipine	0.2	0.2	0.6	0.8	0.1	0.2	0.3	0.6
Medication: Omeprazole	0.2	0.2	0.7	0.8	0.4	0.1	0.1	0.4
Diabetes diagnosed by doctor	0.2	0.3	0.6	0.8	0.5	-0.3	-0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.6	0.7	0.6	-0.3	-0.2	0.8
Medication: Atorvastatin	0.2	0.2	0.5	-0.1	-0.7	-0.7	-0.4	0.2
Fractured/broken bones in last 5 years	0.2	0.3	0.6	0.2	-0.6	0.1	0.8	0.8
Ever depressed for a whole week	0.2	0.3	0.9	-0.2	0.1	0.2	0.8	-0.9
Supplements: Calcium	0.2	0.2	0.7	-0.2	0.4	0.8	-0.1	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.4	-1.2	-0.5	-0.1	-0.3	-0.1
Neuroticism (Nagel 2018)	0.1	0.3	0.7	-0.3	0.4	0.6	0.8	-0.4
Worry (Nagel 2018)	0.1	0.2	0.6	0.3	-0.0	-0.6	0.8	0.2
Crohns Disease (2017)	0.1	0.2	0.4	0.6	0.1	-0.4	0.5	-0.6
Ovarian Cancer	0.1	0.1	0.2	0.3	0.3	-0.3	0.5	0.4
Coronary Artery Disease (CAD)	0.1	0.2	0.4	0.0	0.0	0.2	-0.6	0.6
LDL Cholesterol	0.1	0.2	0.5	-0.3	-0.2	0.6	-0.2	0.7
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.2	0.1	-0.1	0.6	-0.5
Blood Eosinophil Count	0.1	0.6	1.3	0.5	-1.1	0.5	0.4	-1.2
Blood Platelet Count	0.1	1.7	5.2	2.3	0.9	1.4	-0.4	0.5
Height	0.1	2.5	11.2	1.1	-0.0	-0.4	3.3	-0.2
Allergy or Eczema	0.1	0.3	1.2	-0.0	-0.3	1.1	-0.0	-0.3
Hair Pigment	0.1	2.6	6.9	1.1	2.6	0.6	-0.4	2.1
Tanning	0.1	1.6	4.5	-0.1	-1.7	-0.7	0.2	-2.1
Worrier / anxious feelings	0.1	0.2	0.8	-0.0	0.1	-0.1	0.4	0.9
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	0.6	0.2	-0.5	0.9	-0.3
Birth weight of first child	0.1	0.1	0.5	0.1	-0.7	0.0	0.1	0.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.2	-0.6	-0.3	0.4	0.1
Asthma (self-reported)	0.1	0.2	0.3	0.6	0.5	-0.1	-0.4	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.2	-0.4	0.3	-0.1	-0.3
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	-0.2	-0.2	-0.0	-0.3	0.0

Hub : Genes

FIBCD1

Models

Trait associations