TWAS hub - FIGNL2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0747	0.0313	6.5e-06	0.060	0.059	0.066	NA	0.063	2.7e-07	3.5e-07	6.2e-08	NA	1.4e-07
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.2100	0.0650	1.1e-07	0.166	0.118	0.154	NA	0.170	8.5e-10	3.0e-07	3.7e-09	NA	5.2e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Supplements: Fish oil (including cod liver oil)	7.0	9.1	9.5	-2.9	-3.1
Average weekly spirits intake	6.1	7.6	9.0	-3.0	-2.5
Serious illness, injury or assault of a close relative in last 2 years	5.6	6.4	7.0	-2.6	-2.4
Gout (self-reported)	5.3	7.3	10.2	-2.1	-3.2
Supplements: Glucosamine	4.8	6.3	8.9	-3.0	-1.9
Heart attack	4.6	5.9	6.1	-2.5	-2.4
Heart attack/myocardial infarction (self-reported)	4.4	5.7	5.9	-2.4	-2.4
Illnesses of mother	4.3	5.3	6.9	-2.6	-1.9
Qualifications: CSEs or equivalent	4.1	5.5	6.3	2.5	2.2
Medication: Allopurinol	4.1	5.5	6.8	-2.6	-2.0
Commuting to job workplace: Walk	4.0	4.3	7.3	-2.7	-1.1
Mineral and other dietary supplements	3.9	5.3	5.4	2.3	2.3
Ovarian Cancer	3.8	5.0	5.8	2.4	2.0
Heel bone mineral density (BMD) T-score, automated (left)	3.8	8.6	8.8	2.9	3.0
Heel bone mineral density (BMD) T-score, automated (right)	3.4	7.9	9.5	2.5	3.1
Health satisfaction	3.4	4.4	5.2	2.3	1.9
Wears glasses or contact lenses	3.3	3.8	4.0	-1.9	-2.0
Hair/balding pattern: Pattern 4	3.2	7.7	10.0	-2.3	-3.2
Chronic bronchitis/emphysema (mother)	3.2	3.7	4.2	1.8	2.1
Commuting to job workplace: Public transport	3.2	3.8	4.3	-1.8	-2.1
Sensitivity / hurt feelings	3.1	5.3	5.6	2.2	2.4
HbA1C	2.8	3.1	3.3	1.7	1.8
Number of full sisters	2.8	3.4	3.5	-1.8	-1.9
Chronotype (morning person)	2.7	6.2	9.2	-3.0	-1.8
Ever had bowel cancer screening	2.7	3.2	5.1	2.3	1.2
Depression (self-reported)	2.6	3.1	4.0	2.0	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	4.2	2.0	1.3
Supplements: Vitamin C	2.5	2.9	3.5	-1.5	-1.9
Rheumatoid Arthritis	2.4	3.3	3.8	1.9	1.6
Overall health rating	2.3	4.8	6.5	2.5	1.8
Illness, injury, bereavement, stress in last 2 years	2.3	2.9	2.9	1.7	1.7
Lung FVC	2.2	11.4	13.0	3.1	3.6
Financial situation satisfaction	2.2	2.7	3.6	1.9	1.3
Hair/balding pattern: Pattern 3	2.1	3.1	4.6	1.3	2.1
Eye problems/disorders: None of the above	2.1	2.5	3.1	-1.4	-1.8
Alcohol intake frequency.	2.1	4.9	5.4	2.1	2.3
Unable to work because of sickness or disability	2.1	2.7	3.5	1.9	1.4
Blood Red Count	2.0	19.3	27.3	5.2	3.4
Mouth/teeth dental problems: Loose teeth	2.0	2.4	2.8	1.4	1.7
Commuting to job workplace: Car/motor vehicle	2.0	2.3	3.3	1.8	1.1
Diabetes (father)	1.9	2.3	3.2	1.8	1.2
Alcohol usually taken with meals	1.9	3.0	3.1	1.7	1.8
Loud music exposure frequency	1.9	2.1	2.8	1.2	1.7
Had major operations	1.9	2.2	3.8	-1.9	-0.9
Age at last live birth	1.9	2.8	3.1	1.6	1.8
Past tobacco smoking	1.8	3.3	4.7	1.4	2.2
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	2.3	1.5	1.5
Smoking Status	1.7	4.1	7.3	-0.9	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	2.2	1.3	1.5
Alzheimer’s Disease (including proxy)	1.6	2.3	3.8	1.9	0.9
Pulse wave Arterial Stiffness index	1.6	1.9	2.7	-1.0	-1.6
Knee pain experienced in last month	1.6	2.4	4.4	2.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	4.3	-1.6	-2.1
Ever smoked	1.6	2.8	4.1	-1.2	-2.0
Diabetes (mother)	1.5	1.9	1.9	1.4	1.4
Serious illness, injury or assault to yourself	1.5	1.8	2.2	1.2	1.5
Father’s age at death	1.5	2.0	2.2	-1.4	-1.5
Pulse wave peak to peak time	1.5	1.8	2.6	1.0	1.6
Suffer from ‘nerves’	1.5	2.4	2.9	1.4	1.7
Smoking status: Previous	1.5	2.2	3.6	-0.9	-1.9
Age started oral contraceptive pill	1.5	1.8	2.5	1.1	1.6
Shortness of breath walking on level ground	1.4	1.7	2.3	1.0	1.5
Age at First Birth	1.3	1.9	2.1	1.4	1.3
Vitamin and mineral supplements	1.3	1.7	3.2	1.8	0.4
Maternal smoking around birth	1.3	1.9	2.8	1.7	1.0
Hair/balding pattern: Pattern 2	1.3	1.7	2.5	1.6	1.0
Medication: Simvastatin	1.3	1.9	3.1	-1.8	-0.9
Age at first live birth	1.3	2.4	2.4	1.5	1.5
Medication: Metformin	1.2	1.7	2.0	-1.4	-1.2
Average weekly fortified wine intake	1.2	1.4	1.7	-1.3	-1.1
Had menopause	1.2	1.5	2.0	1.0	1.4
Pulse wave reflection index	1.2	1.4	1.6	-1.1	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.0	-1.2	-1.4
Mouth/teeth dental problems	1.1	1.7	2.3	-1.1	-1.5
Fluid intelligence score	1.1	2.3	3.3	-1.8	-1.1
Exposure to tobacco smoke at home	1.1	1.2	1.8	1.3	0.8
Number of operations (self-reported)	1.1	1.6	2.6	-1.6	-0.7
Commuting to job workplace: Cycle	1.1	1.3	2.2	-1.5	-0.6
Intelligence (Savage-Jansen 2018)	1.0	3.1	3.3	-1.8	-1.7
Verbal and Numeric Reasoning (VNR)	1.0	2.3	3.8	-1.9	-0.9
Pulse rate	1.0	1.6	2.0	-1.1	-1.4
Breastfed as a baby	1.0	1.3	1.9	-1.4	-0.8
Headache pain in last month	1.0	1.7	1.9	1.4	1.2
Long-standing illness, disability or infirmity	1.0	1.6	1.8	1.1	1.4
Medication: Gliclazide	1.0	1.2	1.5	-0.9	-1.2
Heart disease (siblings)	1.0	1.3	1.6	1.3	1.0
Systolic blood pressure, automated reading	0.9	2.7	2.8	-1.6	-1.7
Multivitamins +/- minerals	0.9	1.1	1.4	-1.2	0.9
Stomach or abdominal pain in last month	0.9	1.2	1.2	-1.0	-1.1
Had other major operations	0.9	1.1	1.5	-1.2	-0.8
Hip circumference	0.9	4.0	4.1	-2.0	-2.0
Number of full brothers	0.9	1.2	1.5	-1.2	-0.9
Number of children fathered	0.9	1.1	1.4	-1.2	-0.9
Medication: Blood pressure	0.9	1.7	3.0	0.6	1.7
Medication: Atorvastatin	0.9	1.1	1.3	-1.0	-1.1
Alcohol drinker status: Never	0.9	1.1	2.1	0.2	1.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.3	-1.1	-0.8
Supplements: Calcium	0.9	0.9	1.1	-1.1	-0.9
Triglycerides	0.8	1.3	2.4	-0.5	-1.6
Impedance of leg (right)	0.8	3.7	6.4	2.5	1.0
Waist circumference	0.8	2.9	3.2	-1.8	-1.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	3.9	1.3	2.0
Medication: Cholesterol lowering	0.8	1.3	2.0	-1.4	-0.7
Medication: Paracetamol	0.8	1.4	1.8	1.3	1.0
Migraine (self-reported)	0.8	1.0	1.3	-0.9	-1.1
Schizophrenia (2018)	0.7	1.5	1.6	1.2	1.3
Schizophrenia vs Biploar Disorder	0.7	0.9	1.3	1.2	0.7
Alzheimer’s Disease (in father)	0.7	0.8	1.5	1.2	0.2
Bipolar Disorder (2011)	0.7	0.7	1.3	-0.2	-1.1
Hearing difficulty/problems: Yes	0.7	1.0	1.6	-0.6	-1.3
Supplements: Zinc	0.7	0.7	1.3	0.4	1.2
Severe depression (siblings)	0.7	0.8	1.0	0.8	1.0
Taking other prescription medications	0.7	1.1	1.5	0.8	1.2
Medication: Atenolol	0.7	0.9	1.0	0.8	1.0
Impedance of leg (left)	0.7	3.3	6.3	2.5	0.5
Forced vital capacity (FVC)	0.7	2.5	4.3	0.9	2.1
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.7	-1.3	0.3
Medication: Ramipril	0.7	0.9	1.4	-1.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.4	-0.7	-1.2
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	1.3	1.0	1.1
Glaucoma (self-reported)	0.7	0.8	1.3	-0.5	-1.1
Comparative body size at age 10	0.7	1.8	2.1	-1.4	-1.2
Medication: Ibuprofen	0.7	0.8	1.1	-0.7	-1.1
Pulse rate, automated reading	0.7	2.3	3.7	-0.9	-1.9
Family relationship satisfaction	0.7	0.9	1.1	1.1	0.8
Leg pain on walking	0.7	0.9	1.6	1.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.6	1.2	0.3
Leg fat-free mass (right)	0.7	3.6	5.2	-2.3	-1.4
Average weekly red wine intake	0.7	1.1	1.1	-1.0	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.0	0.6	1.0
Qualifications: nursing, teaching	0.7	1.0	1.8	-0.6	-1.3
Leg predicted mass (right)	0.7	3.8	5.5	-2.3	-1.5
Hearing aid user	0.7	0.8	1.4	0.3	1.2
Basal cell carcinoma (self-reported)	0.7	0.8	0.9	0.8	0.9
Reaction Time	0.6	1.1	1.2	1.0	1.1
Hypothyroidism (self reported)	0.6	1.4	1.8	1.0	1.4
Number of treatments/medications taken	0.6	1.0	2.0	-0.2	1.4
Leg fat-free mass (left)	0.6	3.1	4.8	-2.2	-1.2
Current tobacco smoking	0.6	0.9	1.4	-0.7	-1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	-0.5	1.1
High blood pressure (mother)	0.6	0.9	1.1	0.8	1.1
Leg predicted mass (left)	0.6	3.1	4.8	-2.2	-1.2
Financial difficulties in last 2 years	0.6	0.9	1.7	1.3	-0.1
Trunk fat-free mass	0.6	3.5	5.3	-2.3	-1.3
Trunk predicted mass	0.6	3.2	4.9	-2.2	-1.2
Standing height	0.6	6.0	6.5	-2.5	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.2	1.1	0.9
High blood pressure (siblings)	0.6	0.9	1.7	1.3	0.2
Comparative height size at age 10	0.6	3.2	3.6	-1.9	-1.7
Illnesses of siblings: Diabetes	0.6	0.7	1.5	1.2	-0.2
Whole body fat-free mass	0.6	3.6	5.2	-2.3	-1.4
Eye problems/disorders: Cataract	0.6	0.7	1.3	0.2	1.2
Breast cancer (self-reported)	0.6	0.7	0.9	1.0	0.7
Smoking status: Current	0.6	1.0	1.2	-0.8	-1.1
Whole body water mass	0.6	3.4	5.1	-2.3	-1.3
Medication: Paracetamol	0.6	0.9	1.0	0.9	1.0
Fasting Glucose	0.5	0.6	1.2	0.1	-1.1
Neuroticism (2016)	0.5	0.8	1.5	-1.2	-0.1
Heel T-Score	0.5	4.0	4.2	2.0	2.0
Respiratory disease	0.5	1.2	1.4	-1.0	-1.2
Townsend deprivation index at recruitment	0.5	0.7	0.8	-0.9	-0.8
Fed-up feelings	0.5	0.9	1.8	-0.2	-1.3
Hearing difficulty/problems with background noise	0.5	0.8	1.5	-0.4	-1.2
Length of working week for main job	0.5	0.6	0.6	0.7	0.8
Wheeze or whistling in the chest in last year	0.5	0.8	1.6	0.4	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	0.5	1.0
Qualifications: College or University degree	0.5	1.6	2.3	-1.5	-0.9
Hypertension (Self-reported)	0.5	1.3	2.5	-0.3	1.6
Mood swings	0.5	0.8	1.1	-1.1	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.2	1.1	0.7
Back pain experienced in last month	0.5	0.7	1.3	-0.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.8	0.4	1.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.6	-0.7	-0.8
Basal metabolic rate	0.5	2.7	3.8	-2.0	-1.3
Alcohol drinker status: Previous	0.5	0.6	0.9	0.9	0.6
Height	0.4	7.4	9.1	-3.0	-2.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.7	-0.8	-0.6
Diabetes (self-reported)	0.4	0.7	0.7	0.8	0.8
Weight	0.4	2.0	2.1	-1.4	-1.5
Number of live births	0.4	0.6	0.6	0.8	0.7
Prospective memory result	0.4	0.5	1.1	1.0	-0.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.8	0.9	0.3
Arm fat-free mass (right)	0.4	2.1	3.4	-1.8	-0.9
Arm predicted mass (right)	0.4	2.2	3.4	-1.8	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	-0.9	0.5
Mother’s age at death	0.4	0.5	0.8	-0.5	-0.9
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	-0.4	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.7	0.4	0.8
Pain experienced in last month	0.4	0.6	0.9	-0.6	-0.9
Primary Biliary Cirrhosis	0.3	0.4	0.6	-0.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.4	-0.6	-0.4
Blood Platelet Count	0.3	3.6	6.6	-0.8	-2.6
Allergy or Eczema	0.3	0.8	1.0	-1.0	0.7
Cardiovascular Disease	0.3	0.8	0.8	0.9	0.9
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	-0.8	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.2	-1.1	0.5
Sitting height	0.3	2.2	2.8	-1.7	-1.3
Number of incorrect matches in round	0.3	0.6	1.1	-0.2	1.1
Illnesses of siblings	0.3	0.4	0.7	-0.9	-0.1
Alcohol intake versus 10 years previously	0.3	0.5	0.9	0.1	1.0
Birth weight of first child	0.3	0.6	1.1	-1.0	-0.2
Peak expiratory flow (PEF)	0.3	0.8	1.3	0.5	1.2
Medication for pain relief, constipation, heartburn	0.3	0.5	0.6	-0.8	-0.7
Neck or shoulder pain in last month	0.3	0.5	0.6	-0.8	-0.6
Osteoporosis (self-reported)	0.3	0.4	0.4	0.7	0.6
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	-0.1	1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	0.4	0.8
Arm fat-free mass (left)	0.3	1.3	1.8	-1.3	-0.9
Average weekly beer plus cider intake	0.3	0.4	0.6	-0.6	-0.7
Fractured/broken bones in last 5 years	0.3	0.3	0.4	0.6	0.5
Myopia	0.3	0.5	0.6	0.8	-0.6
Impedance of whole body	0.3	1.7	3.3	1.8	0.4
Arm predicted mass (left)	0.3	1.4	1.7	-1.3	-1.0
Bipolar Disorder or Schizophrenia	0.2	0.4	0.6	0.5	0.8
Depressed Affect (Nagel 2018)	0.2	0.4	0.7	-0.8	-0.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.7	-0.1
Major Depression (MDD)	0.2	0.2	0.2	0.4	0.5
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.7	0.1
Mean Putamen Volume	0.2	0.2	0.4	0.6	0.0
HDL Cholesterol	0.2	0.3	0.6	0.3	0.8
Schizophrenia (2014)	0.2	0.5	1.0	0.2	1.0
Blood White Count	0.2	1.2	2.3	0.4	-1.5
Relative age of first facial hair	0.2	0.5	0.6	-0.6	-0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.5	-0.0	0.7
Angina	0.2	0.2	0.4	0.6	0.0
Trunk fat percentage	0.2	0.7	1.3	0.1	-1.2
Hand grip strength (right)	0.2	0.5	0.7	-0.8	-0.5
Age when periods started (menarche)	0.2	0.4	0.4	0.6	0.6
High blood pressure	0.2	0.7	1.2	-0.4	1.1
Trunk fat mass	0.2	1.0	1.8	-0.5	-1.3
Nervous feelings	0.2	0.4	0.8	0.2	0.9
Time employed in main current job	0.2	0.2	0.3	-0.6	-0.2
Falls in the last year	0.2	0.3	0.4	-0.6	0.4
Lung cancer (father)	0.2	0.3	0.5	0.7	0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	-0.5	-0.4
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.2	-0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	0.1	-0.8
Medication: Amlodipine	0.2	0.3	0.5	-0.7	-0.3
Leg fat percentage (right)	0.2	0.7	1.3	1.1	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.3	0.5	0.6
Angina (self-reported)	0.2	0.3	0.6	0.8	0.2
Medication: Omeprazole	0.2	0.2	0.4	0.3	0.6
Heart disease (mother)	0.2	0.2	0.4	-0.1	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.3	-0.5	-0.6
Friendships satisfaction	0.2	0.3	0.5	-0.2	-0.7
Medication: Aspirin	0.2	0.3	0.3	-0.5	-0.6
Average weekly champagne plus white wine intake	0.2	0.2	0.2	0.5	0.5
Guilty feelings	0.2	0.2	0.3	0.6	0.4
Ever taken oral contraceptive pill	0.2	0.2	0.2	-0.4	-0.5
Medication: Lisinopril	0.2	0.3	0.4	-0.5	-0.6
Illnesses of father: High blood pressure	0.2	0.2	0.4	0.6	-0.1
Irritability	0.2	0.3	0.5	0.7	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.0	1.0	-0.5
Cholesterol lowering medication	0.2	0.2	0.4	-0.3	-0.6
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.6	-0.3
Irritable Bowel Disease (IBD)	0.1	0.1	0.1	-0.4	-0.4
Crohns Disease (2012)	0.1	0.2	0.2	0.5	-0.4
LDL Cholesterol	0.1	0.2	0.3	-0.5	-0.4
BMI	0.1	0.5	0.7	-0.5	-0.9
Waist Hip Ratio (WHR)	0.1	0.5	0.7	-0.6	-0.8
Lung FEV1/FVC ratio	0.1	0.5	0.8	0.9	-0.5
Tanning	0.1	1.0	1.6	0.6	1.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.4	0.0
Medication for hormone replacement therapy	0.1	0.1	0.1	0.4	0.2
Medication: Co-codamol	0.1	0.2	0.3	-0.1	-0.6
Relative age voice broke	0.1	0.1	0.2	0.5	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.0	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.3	-0.3
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.1	0.7
Allergy	0.1	0.3	0.6	0.7	-0.3
Neuroticism score	0.1	0.2	0.3	0.6	0.2
Impedance of arm (right)	0.1	0.5	0.9	1.0	-0.3
Arm fat percentage (right)	0.1	0.3	0.5	0.3	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	0.1	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.5	-0.0
Asthma	0.1	0.1	0.2	-0.5	-0.2
Medication: Lansoprazole	0.1	0.1	0.2	0.4	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	-0.2	0.7
Arm fat mass (right)	0.1	0.4	0.8	-0.3	-0.9
Tense / ‘highly strung’	0.1	0.2	0.3	-0.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.5	0.1
Birth weight	0.1	0.3	0.4	-0.6	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.3	0.9
Body fat percentage	0.1	0.4	0.4	0.7	-0.6
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.3	0.3
Worry too long after embarrassment	0.1	0.1	0.2	-0.1	-0.4
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	0.0
Medication: Seretide 50 evohaler	0.1	0.1	0.1	0.1	-0.3
Whole body fat mass	0.1	0.4	0.8	-0.0	-0.9
Chest pain or discomfort	0.1	0.1	0.1	-0.2	0.4
Medication: Aspirin	0.1	0.1	0.1	-0.2	-0.4
Illnesses of father: Heart disease	0.1	0.1	0.1	-0.2	0.4
Arm fat percentage (left)	0.1	0.3	0.6	-0.1	-0.8
Diabetes diagnosed by doctor	0.1	0.2	0.3	0.5	0.4
Asthma (self-reported)	0.1	0.2	0.2	-0.5	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	0.1	0.6
Arm fat mass (left)	0.1	0.6	1.0	-0.5	-1.0
Medication: Blood pressure	0.1	0.2	0.5	-0.1	0.7
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.5	-0.1
Medication: Bendroflumethiazide	0.1	0.2	0.2	0.4	0.4
Leg fat percentage (left)	0.1	0.5	0.9	0.9	-0.3
Risk taking	0.1	0.2	0.3	-0.3	0.6
Diastolic blood pressure, automated reading	0.1	0.4	0.6	-0.8	-0.4
Ever depressed for a whole week	0.1	0.1	0.2	-0.4	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.1	-0.6
Pack years of smoking	0.1	0.2	0.2	-0.4	-0.5
Depression (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.1
Neuroticism (Nagel 2018)	0.0	0.0	0.1	-0.0	0.3
Worry (Nagel 2018)	0.0	0.0	0.0	-0.2	0.2
Crohns Disease (2017)	0.0	0.0	0.1	0.1	-0.3
Ulcerative Colitis (UC)	0.0	0.0	0.1	-0.3	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	-0.2	0.2
Lupus	0.0	0.0	0.1	-0.3	-0.0
Ulcerative Colitis	0.0	0.0	0.0	-0.1	0.0
Blood Eosinophil Count	0.0	0.2	0.4	0.0	-0.6
Systolic Blood Pressure	0.0	0.0	0.0	0.1	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	0.0	0.4
Neuroticism	0.0	0.0	0.0	-0.0	-0.1
Hair Pigment	0.0	0.6	1.1	1.0	0.4
Hand grip strength (left)	0.0	0.1	0.2	-0.5	0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	-0.2	0.1
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	-0.2	-0.2
Pack years adult smoking proportion	0.0	0.0	0.0	0.0	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	0.1	0.2
Body mass index (BMI)	0.0	0.1	0.2	-0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	-0.3	0.2
Qualifications: None of the above	0.0	0.0	0.0	-0.0	-0.1
Pain all over the body in last month	0.0	0.0	0.1	-0.2	-0.0
Worrier / anxious feelings	0.0	0.1	0.1	-0.4	0.1
Happiness	0.0	0.0	0.0	-0.1	0.1
Noisy workplace	0.0	0.1	0.1	-0.3	0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.4	0.0
Impedance of arm (left)	0.0	0.2	0.2	0.4	-0.4
Mean time to correctly identify matches	0.0	0.0	0.0	-0.0	0.2
Leg fat mass (right)	0.0	0.1	0.1	0.3	-0.3
Loneliness, isolation	0.0	0.0	0.1	0.2	-0.1
Medication for cholesterol	0.0	0.1	0.1	-0.1	-0.3
Osteoarthritis (self-reported)	0.0	0.0	0.0	-0.0	-0.2
Miserableness	0.0	0.0	0.1	-0.0	-0.3
Leg fat mass (left)	0.0	0.2	0.3	0.1	-0.6

Hub : Genes

FIGNL2

Models

Trait associations