Hub : Genes

FIP1L1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.2401 0.0731 0.00018 0.172 NA 0.134 NA 0.143 9.2e-07 NA 1.6e-05 NA 8.3e-06
2 TCGA Prostate Adenocarcinoma 0.0348 0.0196 0.00013 0.039 0.034 0.010 NA 0.037 5.1e-05 0.00017 3.1e-02 NA 9.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.5 2.4 3.0 -1.4 1.7
Bipolar Disorder or Schizophrenia 0.1 0.2 0.3 -0.5 -0.3
Depressed Affect (Nagel 2018) 1.2 2.6 3.6 1.3 -1.9
Depression (Nagel 2018) 0.8 1.3 2.0 1.4 -0.7
Intelligence (Savage-Jansen 2018) 0.0 0.0 0.0 0.1 -0.2
Neuroticism (Nagel 2018) 1.8 4.2 5.9 1.6 -2.4
Schizophrenia (2018) 0.8 1.7 3.1 0.4 -1.8
Schizophrenia vs Biploar Disorder 1.1 1.4 2.6 0.5 -1.6
Worry (Nagel 2018) 2.1 4.4 5.6 1.8 -2.4
Alzheimer’s Disease (in mother) 0.7 0.8 1.4 -0.3 1.2
Alzheimer’s Disease (in father) 0.5 0.5 0.8 0.5 0.9
Alzheimer’s Disease (including proxy) 0.9 1.3 2.5 -0.4 1.6
Crohns Disease (2017) 0.0 0.0 0.0 -0.1 -0.2
Irritable Bowel Disease (IBD) 0.0 0.1 0.1 -0.3 0.2
Ulcerative Colitis (UC) 0.2 0.3 0.3 -0.5 0.6
Major Depression (MDD) 0.6 0.7 1.1 0.6 -1.1
Reaction Time 0.2 0.4 0.6 0.4 -0.8
Verbal and Numeric Reasoning (VNR) 0.0 0.0 0.0 -0.2 -0.2
Breast Cancer 0.6 1.5 2.5 0.7 1.6
Ovarian Cancer 0.1 0.1 0.3 -0.1 -0.5
Prostate Cancer 9.4 13.2 15.9 3.2 -4.0
Age at First Birth 0.9 1.4 2.1 -1.4 0.8
Bipolar Disorder (2011) 3.0 2.9 4.1 -2.0 1.3
Body Mass Index (BMI) (2010) 0.1 0.1 0.1 0.4 0.1
Coronary Artery Disease (CAD) 0.5 0.6 0.9 -0.6 0.9
Crohns Disease (2012) 0.2 0.3 0.5 -0.1 -0.7
Mean Putamen Volume 0.3 0.3 0.4 -0.4 0.7
Fasting Glucose 0.1 0.2 0.3 -0.5 0.3
HbA1C 0.5 0.5 0.9 0.3 -1.0
HDL Cholesterol 0.2 0.4 0.8 0.0 0.9
LDL Cholesterol 0.5 0.8 1.5 1.2 -0.2
Lupus 2.0 3.0 3.6 -1.9 1.6
Neuroticism (2016) 0.1 0.1 0.2 0.1 -0.5
Primary Biliary Cirrhosis 0.5 0.8 1.3 0.5 -1.1
Rheumatoid Arthritis 0.4 0.5 1.0 0.0 -1.0
Schizophrenia (2014) 0.4 0.8 1.5 0.3 -1.2
Triglycerides 0.7 1.2 1.6 0.9 -1.3
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.0 0.6 -1.4
Ulcerative Colitis 0.4 0.5 1.1 -1.0 -0.1
Blood Eosinophil Count 0.4 3.5 4.2 2.0 -1.7
Blood Platelet Count 0.1 0.7 0.9 -0.7 -0.9
Blood Red Count 0.1 1.2 1.6 -1.3 -0.9
Blood White Count 0.3 1.9 3.3 -0.7 -1.8
Heel T-Score 2.2 17.4 34.7 -5.9 -0.3
BMI 0.8 4.9 9.6 0.4 3.1
Height 0.6 12.2 22.8 -1.3 4.8
Waist Hip Ratio (WHR) 0.2 0.7 1.1 1.1 -0.6
Systolic Blood Pressure 0.3 1.6 2.9 0.6 -1.7
Smoking Status 0.0 0.0 0.1 0.3 0.1
Allergy or Eczema 0.1 0.4 0.5 0.5 -0.7
Cardiovascular Disease 0.5 1.5 1.7 1.2 -1.3
Hypothyroidism (self reported) 1.0 2.4 4.3 2.1 -0.7
Respiratory disease 0.1 0.2 0.2 0.5 0.5
Type 2 Diabetes (T2D) (2018) 1.7 3.2 5.0 2.2 -1.2
Lung FEV1/FVC ratio 2.1 10.5 11.9 -3.5 3.0
Lung FVC 3.2 16.2 28.1 5.3 -2.1
Neuroticism 3.2 7.6 11.8 1.9 -3.4
Chronotype (morning person) 0.0 0.0 0.0 0.2 -0.1
Hair Pigment 0.2 4.4 8.4 0.6 -2.9
Tanning 0.1 0.9 1.7 1.3 0.3
Hand grip strength (left) 0.7 2.0 2.1 -1.4 1.4
Number of treatments/medications taken 1.7 3.1 6.1 2.5 -0.3
Average weekly spirits intake 0.0 0.0 0.0 0.2 0.1
Sensitivity / hurt feelings 2.5 4.2 5.3 1.8 -2.3
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 0.4 0.4
Hearing difficulty/problems: Yes 0.4 0.6 0.6 0.8 -0.8
Relative age of first facial hair 1.1 2.3 3.5 1.0 -1.9
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.6 0.8 -0.2
Ever used hormone-replacement therapy (HRT) 4.0 5.0 5.6 2.1 -2.4
Ever had hysterectomy (womb removed) 0.9 1.0 1.5 1.2 -0.8
Systolic blood pressure, automated reading 0.8 2.3 3.0 1.2 -1.7
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 3.2 -0.5 1.8
Angina 0.1 0.2 0.2 0.4 0.4
Medication for hormone replacement therapy 0.1 0.1 0.1 -0.4 0.1
Vitamin and mineral supplements 0.2 0.2 0.5 -0.0 0.7
Supplements: Zinc 0.2 0.2 0.2 -0.4 0.4
Medication: Co-codamol 0.7 0.8 1.5 0.1 1.2
Medication: Metformin 0.2 0.2 0.5 -0.0 0.7
Diabetes (father) 1.4 1.7 2.0 -1.4 1.2
Diabetes (mother) 0.2 0.3 0.5 0.1 -0.7
Severe depression (siblings) 1.8 2.0 2.4 -1.2 1.6
Pack years adult smoking proportion 0.1 0.1 0.3 0.5 -0.0
Impedance of leg (right) 0.7 3.5 5.1 -1.4 -2.2
Leg fat-free mass (left) 2.5 13.3 25.0 -1.2 5.0
Trunk fat percentage 0.6 2.4 3.2 -1.3 1.8
Hand grip strength (right) 1.4 3.7 4.3 -1.8 2.1
Townsend deprivation index at recruitment 1.2 1.7 2.0 -1.2 1.4
Current tobacco smoking 2.7 4.4 4.6 -2.1 2.1
Average weekly fortified wine intake 1.6 1.9 2.9 1.0 -1.7
Maternal smoking around birth 0.1 0.1 0.2 -0.5 0.1
Fed-up feelings 2.7 5.0 8.0 1.4 -2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.3 0.4 -0.5
Relative age voice broke 0.5 0.8 1.0 0.7 -1.0
Taking other prescription medications 2.4 3.8 6.7 2.6 -0.9
Age when periods started (menarche) 0.5 1.2 1.7 -1.3 0.8
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 1.7 -0.8 1.3
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.2 8.2 -2.9 0.5
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 1.9 -1.0 1.4
Qualifications: CSEs or equivalent 0.9 1.1 1.2 -1.1 1.0
Serious illness, injury or assault to yourself 1.7 2.1 2.6 -1.3 1.6
High blood pressure 0.7 1.8 2.5 1.1 -1.6
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.2 0.1 -0.4
Multivitamins +/- minerals 0.0 0.0 0.0 -0.2 -0.2
Stomach or abdominal pain in last month 1.5 1.9 2.3 1.2 -1.5
Supplements: Glucosamine 3.0 3.9 5.3 2.3 -1.6
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.1 -0.4 -0.1
Medication: Atenolol 4.0 5.0 5.4 2.1 -2.3
Medication: Levothyroxine sodium 0.4 0.7 1.0 1.0 -0.6
Sitting height 2.5 17.7 25.4 -3.2 5.0
Chronic bronchitis/emphysema (father) 0.9 1.0 1.8 0.5 1.3
High blood pressure (mother) 1.7 2.4 4.2 0.7 -2.0
Body mass index (BMI) 0.6 2.4 4.7 0.2 2.2
Impedance of leg (left) 0.7 3.5 6.0 -1.0 -2.5
Leg predicted mass (left) 2.5 13.0 24.5 -1.2 5.0
Trunk fat mass 1.2 5.0 8.8 -1.2 3.0
Waist circumference 0.7 2.7 5.4 -0.0 2.3
Number of incorrect matches in round 0.3 0.5 1.0 -0.2 1.0
Past tobacco smoking 0.0 0.0 0.1 -0.2 -0.0
Alcohol usually taken with meals 0.3 0.4 0.8 0.4 -0.9
Nervous feelings 1.0 1.9 2.6 1.1 -1.6
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 1.2 1.1 -0.9
Hearing difficulty/problems with background noise 0.1 0.2 0.3 0.6 0.1
Hair/balding pattern: Pattern 2 0.5 0.7 1.0 -0.6 1.0
Had menopause 0.7 0.8 1.4 1.2 -0.5
Had other major operations 0.1 0.1 0.3 0.1 -0.5
Forced vital capacity (FVC) 0.8 3.2 5.9 2.4 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.4 6.7 -2.6 0.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.6 0.8 0.2
Qualifications: None of the above 2.6 5.5 7.2 2.7 -2.0
Financial difficulties in last 2 years 0.1 0.1 0.2 -0.1 -0.5
Mouth/teeth dental problems 0.2 0.3 0.4 -0.6 0.5
Heart attack 0.2 0.3 0.6 0.7 0.2
Allergy 0.2 0.5 0.9 -0.9 0.5
Pain all over the body in last month 0.9 1.0 1.5 -0.6 1.2
Diabetes (self-reported) 0.5 0.8 1.5 1.2 -0.2
Hayfever/allergic rhinitis (self-reported) 0.3 0.5 0.8 0.9 -0.3
Medication: Ramipril 3.3 4.2 4.4 -2.0 2.1
Medication: Simvastatin 0.3 0.4 0.9 0.9 0.0
Fluid intelligence score 0.1 0.1 0.3 -0.5 0.0
Illnesses of siblings 0.2 0.3 0.5 -0.3 -0.7
Neuroticism score 1.9 4.0 7.1 1.0 -2.7
Weight 1.8 9.0 17.2 -0.9 4.2
Impedance of arm (right) 1.0 4.8 7.0 -2.6 -1.6
Arm fat percentage (right) 0.4 1.6 2.5 -0.8 1.6
Trunk fat-free mass 1.7 9.8 19.5 0.1 4.4
Hip circumference 2.1 9.0 15.4 -1.6 3.9
Time employed in main current job 0.3 0.4 0.7 -0.2 0.8
Alcohol intake versus 10 years previously 0.3 0.4 0.5 -0.6 0.7
Father’s age at death 1.5 2.0 2.3 -1.5 1.3
Worrier / anxious feelings 2.7 5.1 6.8 1.8 -2.6
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 2.7 1.3 -1.6
Falls in the last year 0.0 0.0 0.1 0.2 -0.2
Hair/balding pattern: Pattern 3 2.1 3.2 4.7 -1.3 2.2
Number of live births 0.5 0.7 1.5 1.2 0.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 2.0 1.4 -0.4
Pulse rate 0.2 0.3 0.4 0.6 0.5
Happiness 0.3 0.4 0.6 -0.3 -0.8
Noisy workplace 0.4 0.5 0.8 -0.9 0.3
Qualifications: A levels/AS levels or equivalent 1.5 3.3 4.7 -2.2 1.4
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.3 1.2 -0.4
Mouth/teeth dental problems: Dentures 0.2 0.3 0.5 0.3 0.7
Asthma 0.2 0.4 0.4 0.7 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.3 -0.6 0.0
Medication: Cholesterol lowering 0.7 1.1 2.0 1.4 -0.5
Depression (self-reported) 0.1 0.2 0.2 -0.5 0.3
Medication: Lansoprazole 0.4 0.4 0.8 0.9 0.3
Prospective memory result 0.1 0.1 0.2 -0.5 0.1
Lung cancer (father) 1.3 1.5 2.9 -1.7 0.4
Illnesses of mother 0.2 0.3 0.5 -0.2 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.1 1.1 0.4
Pulse wave Arterial Stiffness index 0.1 0.2 0.2 0.5 0.4
Impedance of arm (left) 1.1 4.9 6.0 -2.5 -1.9
Arm fat mass (right) 0.9 3.9 7.3 -0.6 2.7
Trunk predicted mass 1.7 9.7 19.4 0.1 4.4
Standing height 1.5 14.6 23.6 -2.4 4.9
Length of working week for main job 0.0 0.1 0.1 0.3 -0.1
Exposure to tobacco smoke at home 0.1 0.1 0.2 0.0 -0.5
Breastfed as a baby 0.3 0.4 0.8 0.9 -0.1
Tense / ‘highly strung’ 0.4 0.6 0.9 0.5 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.7 -1.3 0.4
Hair/balding pattern: Pattern 4 8.0 19.3 33.8 2.2 -5.8
Birth weight of first child 0.0 0.0 0.0 0.1 -0.1
Peak expiratory flow (PEF) 0.0 0.0 0.0 0.1 -0.2
Pulse wave reflection index 0.3 0.4 0.5 -0.6 0.7
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.5 0.1 -0.7
Loud music exposure frequency 0.8 0.9 1.8 1.3 0.1
Qualifications: O levels/GCSEs or equivalent 3.1 4.9 6.7 -2.6 1.8
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.3 1.2 -0.5
Blood clot in the leg (DVT) 0.3 0.4 0.6 0.4 0.8
Medication: Paracetamol 0.0 0.0 0.0 0.1 0.2
Headache pain in last month 0.2 0.4 0.8 -0.1 -0.9
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 1.9 -1.4 0.2
Glaucoma (self-reported) 0.1 0.1 0.1 -0.1 0.3
Gout (self-reported) 0.0 0.0 0.1 -0.3 0.1
Hypothyroidism/myxoedema (self-reported) 1.1 2.1 3.1 1.8 -1.0
Medication: Amlodipine 0.0 0.0 0.0 -0.1 -0.0
Medication: Ventolin 100micrograms inhaler 1.7 2.2 4.4 2.1 -0.2
Birth weight 0.5 1.1 2.3 1.5 0.2
Chronic bronchitis/emphysema (mother) 0.6 0.7 0.8 0.7 -0.9
High blood pressure (siblings) 0.6 0.8 0.8 -0.9 0.9
Forced vital capacity (FVC), Best measure 0.5 2.0 4.0 2.0 -0.1
Body fat percentage 0.4 1.8 2.7 -0.9 1.6
Leg fat percentage (right) 0.1 0.5 1.0 -0.2 1.0
Arm fat-free mass (right) 1.6 8.2 16.1 0.4 4.0
Exposure to tobacco smoke outside home 0.1 0.1 0.2 0.2 0.4
Comparative body size at age 10 0.4 1.1 2.2 -0.2 1.5
Number of full brothers 0.1 0.1 0.1 -0.1 0.4
Worry too long after embarrassment 0.8 1.3 2.6 0.2 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 3.6 4.6 5.0 -2.2 2.1
Wheeze or whistling in the chest in last year 0.4 0.7 0.7 0.9 -0.8
Number of children fathered 0.7 0.8 1.3 1.1 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.6 3.5 -1.3 1.9
Age at first live birth 2.5 4.5 6.4 -2.5 1.6
Pulse wave peak to peak time 0.1 0.2 0.3 -0.6 -0.1
Health satisfaction 0.7 0.9 1.5 -0.4 1.2
Shortness of breath walking on level ground 1.4 1.6 1.7 1.3 -1.3
Qualifications: College or University degree 0.0 0.1 0.1 -0.3 -0.3
Eye problems/disorders: None of the above 7.9 9.2 11.0 2.7 -3.3
Mouth/teeth dental problems: Loose teeth 0.0 0.1 0.1 0.3 0.2
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.2 0.5
Medication for pain relief, constipation, heartburn 0.5 0.9 1.0 -1.0 0.9
Neck or shoulder pain in last month 0.2 0.3 0.5 0.5 -0.7
Medication: Blood pressure 0.5 0.9 1.8 1.3 -0.2
Angina (self-reported) 0.3 0.3 0.7 -0.0 0.8
Migraine (self-reported) 0.8 0.9 1.5 0.6 -1.2
Medication: Ibuprofen 0.1 0.1 0.2 -0.2 0.4
Medication: Allopurinol 0.2 0.3 0.4 -0.6 -0.3
Medication: Omeprazole 2.5 3.0 3.8 1.4 -2.0
Medication: Seretide 50 evohaler 0.6 0.7 1.1 1.0 -0.5
Mean time to correctly identify matches 1.2 2.4 2.8 1.7 -1.4
Heart disease (mother) 0.0 0.0 0.0 -0.1 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.0 -1.4 0.0
Whole body fat mass 1.3 5.3 9.6 -1.0 3.1
Leg fat mass (right) 1.0 3.7 7.1 -0.6 2.7
Arm predicted mass (right) 1.7 8.8 17.4 0.3 4.2
Pulse rate, automated reading 1.2 3.8 7.0 -0.7 2.6
Alcohol intake frequency. 0.4 0.9 0.9 0.9 -0.9
Comparative height size at age 10 0.8 4.2 8.1 -0.5 2.8
Number of full sisters 0.6 0.7 1.2 -1.1 0.5
Suffer from ‘nerves’ 0.4 0.7 1.3 -0.3 -1.1
Overall health rating 0.1 0.3 0.5 0.7 -0.1
Chest pain or discomfort 0.0 0.1 0.1 -0.0 -0.4
Had major operations 1.0 1.2 1.3 1.0 -1.2
Age at last live birth 0.4 0.6 1.1 -0.1 -1.1
Family relationship satisfaction 0.1 0.1 0.2 -0.5 0.3
Leg pain on walking 1.3 1.6 3.2 1.8 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 0.8 0.9 -0.0
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.1 -0.0 0.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 0.0 -0.7
Medication: Aspirin 0.2 0.3 0.4 0.6 0.5
Supplements: Vitamin C 0.2 0.3 0.4 0.4 -0.6
Knee pain experienced in last month 0.4 0.6 0.8 0.6 -0.9
Hypertension (Self-reported) 0.5 1.3 2.2 0.7 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.8 0.5 -0.9
Illnesses of father: Heart disease 0.1 0.1 0.1 0.2 -0.4
Illnesses of siblings: Diabetes 1.4 1.8 2.8 1.7 -0.9
Smoking status: Previous 0.6 0.9 1.2 1.1 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.3 5.1 -1.2 2.3
Whole body fat-free mass 2.0 11.6 23.0 -0.4 4.8
Leg fat-free mass (right) 2.3 12.5 23.8 -1.1 4.9
Arm fat percentage (left) 0.4 1.4 2.3 -0.7 1.5
Average weekly red wine intake 0.1 0.2 0.3 0.3 0.6
Handedness (chirality/laterality): Left-handed 2.2 2.6 3.9 2.0 -1.2
Mood swings 0.6 1.2 2.3 0.1 -1.5
Loneliness, isolation 0.2 0.3 0.5 0.3 -0.7
Long-standing illness, disability or infirmity 1.9 3.0 5.9 2.4 0.1
Ever had bowel cancer screening 0.7 0.8 1.0 0.8 -1.0
Diabetes diagnosed by doctor 0.3 0.4 0.6 0.5 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.0 0.8 -1.0
Friendships satisfaction 0.2 0.2 0.3 -0.6 0.3
Qualifications: nursing, teaching 0.8 1.3 1.5 -1.2 1.0
Commuting to job workplace: Walk 2.9 3.2 4.6 -1.3 2.1
Eye problems/disorders: Cataract 6.0 7.0 8.2 -2.4 2.9
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 -0.2 -0.2
Medication for cholesterol 0.1 0.1 0.2 -0.1 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.6 -0.8 0.1
Back pain experienced in last month 0.7 1.0 1.6 1.3 -0.5
Mineral and other dietary supplements 1.2 1.6 2.4 -1.6 0.9
Breast cancer (self-reported) 0.2 0.3 0.6 -0.7 0.0
Asthma (self-reported) 0.3 0.6 1.1 1.1 0.2
Osteoporosis (self-reported) 0.2 0.2 0.3 0.6 -0.3
Osteoarthritis (self-reported) 3.7 4.8 7.4 2.7 -1.5
Medication: Aspirin 0.4 0.5 0.8 0.5 0.9
Medication: Gliclazide 0.5 0.6 1.2 -0.2 1.1
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 -0.0 -0.4
Smoking status: Current 2.3 3.6 3.8 -1.9 1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.1 7.4 2.7 -0.9
Whole body water mass 2.0 11.1 22.2 -0.3 4.7
Leg predicted mass (right) 2.3 12.5 23.7 -1.1 4.9
Arm fat mass (left) 0.8 3.4 6.5 -0.6 2.5
Number of self-reported non-cancer illnesses 2.3 4.0 7.0 2.6 -1.0
Average weekly champagne plus white wine intake 0.0 0.0 0.0 -0.1 0.0
Miserableness 0.4 0.6 1.2 -0.2 -1.1
Guilty feelings 0.5 0.8 1.0 0.8 -1.0
Wears glasses or contact lenses 0.1 0.1 0.2 -0.4 -0.1
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.5 -0.1
Hearing aid user 1.6 1.8 2.3 1.2 -1.5
Mother’s age at death 2.6 3.3 3.5 1.7 -1.9
Financial situation satisfaction 0.8 1.0 1.9 -0.4 1.4
Tinnitus: Yes, now most or all of the time 6.4 7.5 9.3 2.4 -3.1
Commuting to job workplace: Public transport 0.4 0.5 1.0 0.0 1.0
Eye problems/disorders: Glaucoma 1.0 1.2 1.3 -1.0 1.1
Medication: Blood pressure 1.5 2.9 3.9 1.3 -2.0
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.1 0.4 0.0
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 0.6 -0.1
High cholesterol (Self-reported) 0.8 1.4 2.9 1.7 -0.1
Medication: Bendroflumethiazide 0.9 1.4 1.8 1.4 -1.0
Medication: Paracetamol 0.2 0.3 0.4 -0.6 0.5
Medication: Lisinopril 1.5 2.0 2.6 1.2 -1.6
Medication: Atorvastatin 0.1 0.1 0.2 0.5 -0.1
Illnesses of father: High blood pressure 0.4 0.5 0.6 -0.6 0.8
Alcohol drinker status: Never 0.1 0.1 0.1 -0.0 0.3
Ever smoked 0.3 0.5 0.6 -0.7 0.8
Basal metabolic rate 2.2 12.0 23.4 -0.7 4.8
Leg fat percentage (left) 0.1 0.4 0.7 0.2 0.8
Arm fat-free mass (left) 1.4 7.3 14.5 0.3 3.8
Number of operations (self-reported) 0.5 0.7 1.2 0.5 -1.1
Average weekly beer plus cider intake 0.5 0.7 0.8 -0.9 0.8
Irritability 1.1 1.8 3.0 -1.7 0.8
Risk taking 0.1 0.2 0.3 -0.2 0.5
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.4 0.7 -0.5
Fractured/broken bones in last 5 years 14.5 18.7 19.0 4.3 -4.4
Age started oral contraceptive pill 0.1 0.2 0.3 -0.2 -0.5
Diastolic blood pressure, automated reading 0.1 0.4 0.5 -0.7 -0.6
Ever depressed for a whole week 0.1 0.1 0.2 0.5 -0.1
Unable to work because of sickness or disability 0.3 0.4 0.8 0.9 -0.2
Commuting to job workplace: Cycle 0.1 0.1 0.1 -0.3 0.2
Myopia 0.1 0.1 0.2 0.2 -0.4
Vascular/heart problems diagnosed by doctor 1.2 3.2 3.4 -1.7 1.8
Cholesterol lowering medication 0.2 0.4 0.5 0.4 0.7
Medication: Omeprazole (e.g. Zanprol) 3.4 4.2 6.1 1.5 -2.5
Pain experienced in last month 1.9 3.1 3.8 -1.6 1.9
Supplements: Calcium 1.0 1.1 1.7 0.7 -1.3
Basal cell carcinoma (self-reported) 0.3 0.3 0.4 -0.5 -0.6
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.7 0.8 0.4
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 0.8 0.3 0.9
Heart disease (siblings) 1.7 2.0 2.1 1.4 1.4
Alcohol drinker status: Previous 3.8 4.3 5.5 1.7 -2.4
Pack years of smoking 0.3 0.4 0.8 0.9 -0.2
Impedance of whole body 0.9 4.6 5.4 -1.9 -2.3
Leg fat mass (left) 0.8 3.2 6.2 -0.3 2.5
Arm predicted mass (left) 1.5 7.8 15.5 0.4 3.9