TWAS hub - FKBP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.272	0.0830	5.7e-05	0.065	NA	0.115	NA	0.143	3.8e-03	NA	1.4e-04	NA	2.1e-05
2	GTEx	Esophagus Mucosa	0.090	0.0350	2.6e-04	0.024	NA	0.051	NA	0.045	9.6e-03	NA	2.6e-04	NA	5.5e-04
3	GTEx	Esophagus Muscularis	0.116	0.0370	2.4e-05	0.124	NA	0.063	NA	0.094	5.6e-08	NA	1.1e-04	NA	2.4e-06
4	ROSMAP	Brain Pre-frontal Cortex	0.282	0.0627	7.1e-14	0.061	0.155	0.136	0.156	0.088	2.5e-08	1.8e-19	4.6e-17	1.6e-19	1.9e-11
5	TCGA	Cervical Squamous Cell Carcinoma	0.095	0.0500	5.0e-03	0.075	0.033	0.037	NA	0.044	1.5e-04	9.8e-03	6.4e-03	NA	3.1e-03
6	TCGA	Stomach Adenocarcinoma	0.043	0.0240	1.9e-03	-0.001	0.027	0.012	NA	0.000	3.7e-01	4.6e-03	4.0e-02	NA	3.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Mean time to correctly identify matches	8.1	15.5	20.1	4.4	4.0	3.6	4.0	2.9	4.5
Blood Platelet Count	7.8	91.0	139.2	-7.3	-11.3	-10.9	-7.0	-7.6	-11.8
Reaction Time	7.5	14.4	19.6	3.9	4.4	3.4	3.4	3.1	4.4
Alcohol drinker status: Never	6.9	8.3	20.5	-4.5	-1.9	-2.4	-2.9	-2.0	-2.7
Pulse rate, automated reading	5.5	17.6	35.9	-2.8	-6.0	-4.5	-3.0	-3.8	-4.2
Alcohol intake versus 10 years previously	5.3	8.0	12.0	2.8	2.7	3.5	3.1	1.5	3.0
Number of incorrect matches in round	5.1	8.5	11.4	3.1	3.4	2.8	2.1	3.0	3.0
Pulse rate	4.9	8.3	14.4	-1.5	-3.8	-2.7	-3.3	-2.6	-2.9
Bipolar Disorder or Schizophrenia	4.7	11.4	32.8	5.7	2.1	3.7	3.1	1.6	2.3
Arm fat mass (right)	4.4	18.1	27.0	-4.6	-5.2	-4.8	-2.6	-2.6	-5.0
Primary Biliary Cirrhosis	4.3	6.2	22.0	0.7	-2.6	0.6	-1.8	-4.7	-2.0
Arm fat mass (left)	4.3	17.8	26.2	-4.6	-5.1	-4.8	-2.6	-2.4	-4.8
Hip circumference	4.2	17.9	25.8	-5.0	-4.0	-5.1	-4.2	-1.3	-4.6
Chronic bronchitis/emphysema (mother)	4.0	4.6	7.8	-0.1	-2.6	-2.0	-1.5	-2.8	-2.7
Arm fat percentage (right)	3.9	15.3	24.6	-3.9	-5.0	-4.3	-2.0	-2.6	-4.8
Number of live births	3.8	5.4	11.4	-0.4	-3.4	-0.9	-1.7	-2.9	-3.0
BMI	3.6	21.0	34.9	-5.9	-5.3	-5.5	-2.0	-2.4	-4.8
Trunk fat percentage	3.6	14.6	20.8	-3.9	-4.6	-4.2	-2.6	-2.5	-4.5
Trunk fat mass	3.5	14.9	19.8	-4.4	-4.5	-4.2	-2.8	-2.2	-4.4
Gout (self-reported)	3.5	4.8	14.9	3.9	0.0	3.1	0.7	-0.8	1.8
Whole body fat mass	3.5	14.8	20.5	-4.4	-4.5	-4.2	-2.7	-2.3	-4.4
Arm fat percentage (left)	3.5	14.0	21.4	-3.9	-4.6	-4.3	-2.0	-2.2	-4.4
Bipolar Disorder (2011)	3.4	3.3	8.8	3.0	1.8	2.3	1.6	0.0	0.0
Body fat percentage	3.3	13.2	20.5	-3.8	-4.5	-3.9	-2.2	-2.4	-4.3
Schizophrenia (2018)	3.2	6.7	19.0	4.4	1.5	3.3	1.8	1.1	1.9
Schizophrenia (2014)	3.2	7.0	15.2	3.9	2.0	3.0	2.5	1.5	2.2
Bipolar Disorder (2018)	3.0	4.8	13.8	3.7	1.5	1.8	2.6	1.2	1.2
Alzheimer’s Disease (including proxy)	3.0	4.4	8.5	2.9	1.9	1.5	2.2	1.7	2.0
Body mass index (BMI)	3.0	12.8	23.8	-3.5	-4.9	-4.0	-1.5	-2.1	-4.2
Weight	3.0	14.8	21.3	-4.6	-4.4	-4.4	-2.9	-1.9	-4.1
Supplements: Calcium	3.0	3.3	8.4	2.8	1.4	2.9	0.4	-0.2	1.2
Alzheimer’s Disease (in mother)	2.9	3.4	5.0	2.2	2.1	1.5	1.9	1.6	1.5
Relative age of first facial hair	2.9	6.1	11.4	-0.3	-2.9	-0.9	-2.8	-3.4	-2.8
Supplements: Zinc	2.9	3.2	4.7	2.2	1.9	2.0	1.7	0.8	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.9	3.8	7.2	2.7	1.7	1.5	0.8	1.9	2.5
Handedness (chirality/laterality): Left-handed	2.9	3.5	6.6	0.1	2.0	2.2	1.8	1.6	2.6
Basal cell carcinoma (self-reported)	2.9	3.4	8.6	-2.9	1.2	-1.2	1.4	2.5	0.7
Taking other prescription medications	2.8	4.3	10.1	3.0	-0.6	3.2	1.1	-1.8	1.4
Length of working week for main job	2.8	3.1	5.0	-2.0	-1.3	-1.7	-2.2	-1.6	-1.8
Leg fat mass (right)	2.8	10.7	16.6	-4.0	-4.1	-3.4	-2.0	-2.0	-3.6
Illnesses of father: High blood pressure	2.8	3.4	8.4	0.6	1.7	2.2	1.4	1.5	2.9
Number of operations (self-reported)	2.8	4.1	7.7	-1.6	-2.2	-2.8	-2.0	-1.4	-1.9
Leg fat mass (left)	2.8	11.0	18.0	-3.8	-4.2	-3.4	-2.0	-2.1	-3.7
Diabetes (mother)	2.7	3.4	5.1	-0.1	-2.3	-2.1	-2.1	-1.9	-1.7
Osteoporosis (self-reported)	2.7	3.4	8.8	3.0	0.1	2.3	0.2	-2.4	0.1
Crohns Disease (2017)	2.6	5.8	11.5	3.1	-2.2	1.8	-2.1	-3.4	-0.8
Mineral and other dietary supplements	2.6	3.5	5.1	-1.6	-2.2	-1.1	-2.3	-2.0	-1.9
Crohns Disease (2012)	2.5	4.0	9.8	2.3	-2.0	1.8	-0.8	-3.1	-0.8
Pulse wave reflection index	2.5	3.1	6.0	-0.6	1.8	2.0	1.9	0.9	2.5
Pain type(s) experienced in last month: Hip pain	2.5	3.1	5.2	-2.0	-2.1	-1.7	-0.8	-1.2	-2.3
Body Mass Index (BMI) (2010)	2.3	3.1	6.0	-2.0	-1.6	-2.4	-1.0	-0.5	-2.2
Vitamin and mineral supplements	2.3	3.2	8.0	-2.8	-1.3	-2.6	-1.0	0.3	-1.0
Birth weight of first child	2.3	4.2	9.9	1.7	-3.2	-0.7	0.5	-2.9	-1.9
Chest pain or discomfort	2.3	3.3	4.8	-1.9	-2.2	-1.9	-1.5	-1.5	-1.9
Medication: Aspirin	2.3	3.0	10.0	1.9	-0.4	1.1	3.2	-0.6	1.6
Number of self-reported non-cancer illnesses	2.3	3.9	6.9	1.9	-1.1	2.6	2.6	-1.6	1.5
Medication: Simvastatin	2.2	3.2	9.0	1.0	-3.0	0.1	-0.1	-3.0	-0.6
Leg fat percentage (right)	2.2	8.0	15.1	-3.0	-3.9	-2.8	-1.0	-2.0	-3.3
Medication: Aspirin	2.2	2.9	7.9	2.1	-0.8	1.2	2.8	-1.1	1.3
Illnesses of father: Heart disease	2.2	3.0	5.2	2.3	1.0	2.2	1.3	0.4	2.3
Illnesses of father: None of the above (group 1)	2.2	2.8	5.6	-1.2	-0.8	-2.0	-2.2	-0.5	-2.4
Wears glasses or contact lenses	2.2	2.5	6.3	-0.2	-2.5	-1.7	-0.2	-2.0	-1.5
Leg predicted mass (left)	2.1	11.2	19.6	-4.4	-3.5	-3.7	-3.1	-1.4	-3.2
Waist circumference	2.1	7.5	14.5	-3.1	-3.8	-3.0	-1.7	-1.9	-2.3
Emphysema/chronic bronchitis	2.1	2.4	6.5	-0.3	1.1	1.0	2.5	1.4	1.9
Leg fat percentage (left)	2.1	7.5	15.6	-2.5	-4.0	-2.7	-0.9	-2.1	-3.3
Fractured/broken bones in last 5 years	2.1	2.7	11.0	0.2	-0.4	0.5	-3.3	-1.9	-1.1
Irritable Bowel Disease (IBD)	2.0	4.7	9.1	2.9	-2.1	1.7	-1.8	-3.0	-0.5
Hypothyroidism (self reported)	2.0	4.7	12.4	2.6	-0.9	2.8	0.2	-3.5	0.8
Leg fat-free mass (left)	2.0	10.8	18.7	-4.3	-3.4	-3.7	-3.1	-1.4	-3.1
Mouth/teeth dental problems: Dentures	2.0	3.4	7.6	-1.8	-2.8	-1.5	0.1	-2.0	-1.9
Peak expiratory flow (PEF)	2.0	4.6	6.9	-0.5	-2.5	-2.2	-2.2	-2.2	-2.6
Birth weight	2.0	4.4	10.3	0.8	-2.1	-1.9	-1.4	-2.2	-3.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	3.6	-1.8	-1.9	-1.9	-1.3	-0.9	-1.4
Verbal and Numeric Reasoning (VNR)	1.9	4.4	10.3	-1.6	-2.6	-3.2	-1.4	-1.4	-1.8
Medication: Co-codamol	1.9	2.2	3.5	-1.0	-1.7	-1.4	-1.8	-0.8	-1.9
Relative age voice broke	1.9	2.9	6.9	0.2	-1.8	-0.2	-1.7	-2.6	-2.0
Qualifications: College or University degree	1.9	6.1	19.5	-1.1	-2.1	-4.4	-2.3	-0.5	-2.4
Mouth/teeth dental problems: Loose teeth	1.9	2.2	3.5	-0.5	1.1	1.9	1.4	1.7	1.8
Leg pain on walking	1.9	2.4	3.8	-1.2	-1.7	-1.6	-1.0	-1.9	-1.6
Qualifications: nursing, teaching	1.9	2.9	9.4	-2.1	-0.8	-3.1	-1.1	0.9	-0.8
Guilty feelings	1.9	2.8	7.9	1.0	-1.3	0.0	-2.1	-2.8	-1.3
Waist Hip Ratio (WHR)	1.8	8.1	17.1	3.0	0.5	3.2	3.3	-1.0	4.1
Multivitamins +/- minerals	1.8	2.2	6.4	2.5	1.1	2.0	0.9	0.3	1.0
Had other major operations	1.8	2.2	7.9	-0.8	-0.5	-0.8	-2.8	-1.2	-1.5
Number of children fathered	1.8	2.0	3.4	0.8	-1.7	-0.9	-1.2	-1.8	-1.7
Medication: Allopurinol	1.8	2.4	5.9	2.4	-0.1	2.3	0.4	-1.1	1.4
Arm fat-free mass (left)	1.8	9.0	15.3	-3.9	-3.4	-3.2	-2.5	-1.6	-2.8
Cholesterol lowering medication	1.8	2.7	7.0	1.5	-2.6	0.1	1.3	-2.3	-0.2
Intelligence (Savage-Jansen 2018)	1.7	5.1	11.7	-1.6	-3.2	-3.4	-0.1	-1.6	-1.8
Prospective memory result	1.7	2.2	7.6	2.7	0.7	1.6	1.4	-0.6	0.1
Exposure to tobacco smoke outside home	1.7	2.3	3.9	-1.4	-1.7	-1.1	-0.2	-2.0	-2.0
Shortness of breath walking on level ground	1.7	2.0	5.2	-0.3	-2.3	-0.9	-1.1	-1.7	-1.3
Had major operations	1.7	2.0	4.5	-0.1	-2.1	-2.1	1.0	-0.7	-1.3
Basal metabolic rate	1.7	9.2	18.1	-4.2	-3.1	-3.4	-2.8	-1.2	-2.8
Fed-up feelings	1.6	3.0	11.3	1.0	0.4	3.4	-0.1	-2.2	0.9
Chronic bronchitis/emphysema (father)	1.6	1.9	3.7	-0.2	-1.9	-1.2	0.1	-1.7	-1.8
Leg predicted mass (right)	1.6	8.4	13.0	-3.6	-3.2	-3.3	-2.8	-1.2	-2.8
Ever had prostate specific antigen (PSA) test	1.6	1.8	4.2	2.0	1.3	1.9	-0.1	0.5	1.1
Arm predicted mass (left)	1.6	8.1	15.0	-3.9	-3.1	-3.1	-2.4	-1.3	-2.7
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	6.2	2.5	-1.0	0.3	1.7	-1.1	0.5
Diabetes (father)	1.5	1.8	4.9	-2.2	-0.7	-2.0	0.7	0.9	-0.3
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	9.9	1.4	-1.3	2.0	0.0	-3.1	-0.0
Leg fat-free mass (right)	1.5	8.3	13.0	-3.6	-3.1	-3.3	-2.7	-1.1	-2.7
Hearing aid user	1.5	1.6	4.3	1.2	1.3	2.1	1.0	0.2	1.2
High cholesterol (Self-reported)	1.5	2.7	8.0	2.8	-0.7	1.6	1.9	-1.0	1.0
Rheumatoid Arthritis	1.4	1.9	6.1	1.2	-0.4	1.5	-1.3	-2.5	-0.3
Smoking Status	1.4	3.3	11.1	0.8	-1.8	2.1	-0.4	-3.3	-0.8
Number of treatments/medications taken	1.4	2.4	4.0	1.6	-1.0	2.0	1.9	-1.7	0.9
Medication: Levothyroxine sodium	1.4	2.4	9.5	0.4	-1.2	1.6	-0.8	-3.1	-0.3
Time employed in main current job	1.4	1.6	7.0	-0.6	0.9	1.0	-2.6	0.1	0.5
Worrier / anxious feelings	1.4	2.7	6.4	2.5	1.2	1.7	1.6	0.3	1.7
Worry too long after embarrassment	1.4	2.4	5.5	-0.7	-1.3	-1.1	-2.4	-1.5	-1.9
Worry (Nagel 2018)	1.3	2.8	6.4	0.9	2.5	2.2	-0.5	0.9	1.9
Lung FEV1/FVC ratio	1.3	6.6	13.0	0.0	-3.6	-2.8	-0.7	-2.7	-3.3
Neuroticism	1.3	3.2	9.6	1.2	2.2	3.1	-0.5	-0.2	1.7
Medication for hormone replacement therapy	1.3	1.5	4.2	-0.8	-1.1	-0.8	-2.1	-1.0	-1.0
Past tobacco smoking	1.3	2.5	7.8	-0.8	1.7	-1.0	1.3	2.8	0.8
Tense / ‘highly strung’	1.3	2.1	7.2	2.7	0.8	1.9	-0.2	-0.7	0.8
Number of full brothers	1.3	1.7	4.1	0.3	-2.0	-0.8	-0.2	-1.4	-1.8
Pulse wave peak to peak time	1.3	1.5	2.8	-1.1	0.8	-1.5	-1.2	1.7	-0.7
Diabetes diagnosed by doctor	1.3	2.1	7.0	0.1	-2.6	-0.8	0.2	-2.1	-0.9
Eye problems/disorders: Glaucoma	1.3	1.5	2.7	-1.3	-0.9	-0.8	-1.3	-1.6	-1.2
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.6	0.8	1.4	0.4	1.3	1.9	1.4
Ever depressed for a whole week	1.3	1.6	7.1	2.7	-0.9	0.4	0.6	-1.0	0.1
Medication: Metformin	1.2	1.7	6.5	0.3	-2.6	-0.5	0.1	-1.8	-0.7
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.7	0.2	1.1	0.9	1.6	1.0	1.6
Medication: Ramipril	1.2	1.5	2.9	-1.0	-1.6	-0.4	-1.7	-1.5	-0.6
Breastfed as a baby	1.2	1.5	3.2	1.6	0.5	0.2	1.2	1.8	1.2
Migraine (self-reported)	1.2	1.4	2.8	0.9	0.7	0.8	1.2	1.6	1.7
Mood swings	1.2	2.1	7.6	1.5	0.6	2.8	-0.1	-1.5	0.5
Mouth/teeth dental problems: Mouth ulcers	1.2	1.8	6.0	2.5	1.2	0.9	1.5	0.6	0.5
Whole body water mass	1.2	7.1	14.6	-3.8	-2.6	-2.9	-2.6	-1.0	-2.3
Ever smoked	1.2	2.2	4.8	1.6	-0.4	2.2	-0.9	-2.2	0.4
Average weekly beer plus cider intake	1.2	1.7	4.0	-0.9	1.7	2.0	0.5	0.4	1.4
Depressed Affect (Nagel 2018)	1.1	2.3	8.6	1.3	1.1	2.9	-0.2	-1.0	0.9
Schizophrenia vs Biploar Disorder	1.1	1.5	4.8	-1.0	-0.6	-1.2	-2.2	-0.3	-1.2
HbA1C	1.1	1.2	1.8	1.3	0.6	1.3	0.9	0.9	1.3
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	5.2	1.2	0.3	0.2	2.3	0.4	0.7
Had menopause	1.1	1.4	2.4	-0.0	-1.6	-1.3	-1.4	-0.5	-1.5
Mouth/teeth dental problems	1.1	1.7	3.7	0.7	1.9	0.8	-0.7	1.7	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.0	0.2	1.2	1.1	1.7	0.8	1.2
Depression (self-reported)	1.1	1.3	4.0	2.0	-0.3	1.0	1.5	0.5	0.4
Pulse wave Arterial Stiffness index	1.1	1.2	3.0	0.8	-0.8	1.4	0.9	-1.7	0.6
Arm predicted mass (right)	1.1	5.8	13.1	-3.6	-2.3	-2.7	-2.3	-0.5	-1.9
Whole body fat-free mass	1.1	6.5	14.4	-3.8	-2.4	-2.8	-2.5	-0.7	-2.1
Average weekly red wine intake	1.1	1.6	4.6	0.6	1.6	-0.7	0.9	2.1	1.1
Blood Eosinophil Count	1.0	7.5	17.1	1.5	2.1	-0.0	2.8	4.1	3.7
Age when periods started (menarche)	1.0	2.4	4.7	-1.0	-1.0	-1.3	-2.2	-1.2	-2.1
High blood pressure (mother)	1.0	1.4	3.2	0.4	0.8	1.0	1.2	1.8	1.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.2	1.8	-1.3	-0.1	0.6	-1.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	6.9	2.6	-0.9	0.8	0.1	-1.0	-0.7
Arm fat-free mass (right)	1.0	5.1	11.3	-3.4	-2.2	-2.5	-2.1	-0.6	-1.8
Health satisfaction	1.0	1.3	4.2	-0.0	-2.0	-0.5	-0.4	-1.6	-0.8
Alcohol intake frequency.	1.0	2.3	5.2	-0.6	-2.3	-1.2	-0.8	-2.0	-1.6
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.1	1.1	-1.6	0.7	-0.1	-1.8	-0.3
Smoking status: Previous	1.0	1.5	3.1	0.9	-1.4	0.7	-1.6	-1.8	-0.7
Medication: Lisinopril	1.0	1.3	2.1	-1.2	-1.2	-1.4	-1.1	-0.8	-1.1
Age started oral contraceptive pill	1.0	1.3	3.2	-0.9	-1.1	-0.9	1.8	-1.1	-0.5
HDL Cholesterol	0.9	1.4	5.1	-0.1	-0.1	-0.4	-2.3	-0.3	-1.8
Systolic Blood Pressure	0.9	4.6	14.0	-0.2	1.2	3.1	1.5	-0.6	3.7
Allergy or Eczema	0.9	2.4	7.8	0.5	0.7	0.1	2.2	2.8	1.0
Sensitivity / hurt feelings	0.9	1.5	4.8	1.5	-0.9	0.8	0.6	-2.2	-0.2
Maternal smoking around birth	0.9	1.3	3.6	-0.0	-0.1	1.9	-1.4	-1.5	0.1
Alcohol usually taken with meals	0.9	1.4	3.3	-0.2	-1.6	-1.8	-0.7	0.0	-1.4
Nervous feelings	0.9	1.6	3.7	0.8	1.5	1.9	0.9	0.9	1.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	4.9	-0.7	-1.0	-0.7	2.2	0.2	-0.4
Fluid intelligence score	0.9	1.8	6.5	-1.0	-1.7	-2.5	-0.1	-0.3	-0.4
Neuroticism score	0.9	1.8	6.0	1.6	0.8	2.4	0.0	-1.0	0.9
Asthma	0.9	1.7	4.8	-0.9	-2.2	-1.8	-0.3	-0.3	-1.1
Illnesses of mother	0.9	1.1	2.6	-1.6	-0.2	-0.8	-1.6	0.4	-0.8
Medication: Paracetamol	0.9	1.5	3.7	0.1	-0.3	0.7	-1.6	-1.9	-1.5
Glaucoma (self-reported)	0.9	1.0	2.5	-0.7	-0.6	-0.1	-1.5	-1.6	-0.7
Number of full sisters	0.9	1.1	1.8	1.0	-1.2	0.3	-1.0	-1.4	-1.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.9	0.1	-1.4	-2.0	-0.4	-0.1	-0.9
Hypertension (Self-reported)	0.9	2.4	7.6	-1.2	-2.1	0.9	0.2	-2.8	-0.0
Loneliness, isolation	0.9	1.2	4.8	-1.0	-1.0	0.2	-0.6	-2.2	-0.3
Long-standing illness, disability or infirmity	0.9	1.3	2.4	1.3	-0.1	1.6	1.6	-0.2	1.2
Medication for cholesterol	0.9	1.4	4.3	0.3	1.9	-0.2	0.6	2.1	0.2
Mother’s age at death	0.9	1.1	2.3	1.4	1.5	1.0	0.8	0.8	0.5
Medication: Atorvastatin	0.9	1.1	2.3	0.8	-1.2	0.6	1.3	-1.5	-0.3
Vascular/heart problems diagnosed by doctor	0.9	2.4	7.7	0.5	2.2	-0.8	-1.0	2.8	0.0
Pack years of smoking	0.9	1.3	3.3	0.7	0.7	1.0	1.8	0.8	1.4
Prostate Cancer	0.8	1.1	2.4	0.8	1.5	1.1	0.9	0.9	1.0
Coronary Artery Disease (CAD)	0.8	1.0	2.9	1.7	0.4	1.0	1.1	-0.2	0.9
Impedance of leg (left)	0.8	3.8	6.9	2.1	2.6	2.5	0.6	0.5	2.1
Trunk fat-free mass	0.8	4.3	11.8	-3.4	-1.6	-2.1	-2.2	-0.4	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.8	1.6	-1.2	0.7	-0.1	-1.7	-0.7
Medication: Cholesterol lowering	0.8	1.2	3.0	0.9	-1.5	0.3	1.0	-1.7	0.1
Medication: Lansoprazole	0.8	0.9	3.0	1.7	-1.0	1.1	0.6	-0.2	0.5
Trunk predicted mass	0.8	4.4	11.6	-3.4	-1.6	-2.2	-2.2	-0.5	-1.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.0	1.7	-0.1	1.3	0.7	-0.8	0.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.5	1.1	-0.5	0.7	0.8	-1.6	-0.4
Knee pain experienced in last month	0.8	1.3	3.6	-1.1	-1.1	0.1	-0.6	-1.9	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	7.6	-0.4	-0.0	-1.3	-2.8	-0.2	-0.7
Eye problems/disorders: Cataract	0.8	0.9	2.7	1.2	-0.3	0.2	1.7	0.1	1.0
Asthma (self-reported)	0.8	1.6	3.5	-1.2	-1.9	-1.9	-0.3	0.0	-0.9
Miserableness	0.8	1.4	5.9	1.0	0.9	2.4	0.3	-0.2	0.6
Medication: Bendroflumethiazide	0.8	1.2	4.0	-0.5	-1.4	0.3	1.0	-2.0	-0.2
Irritability	0.8	1.4	3.7	0.6	1.7	1.9	-0.9	0.1	0.9
Commuting to job workplace: Cycle	0.8	0.9	2.0	0.7	1.4	0.3	-0.7	1.2	1.0
Depression (Nagel 2018)	0.7	1.0	2.6	1.4	1.6	1.0	-0.6	-0.2	0.3
Neuroticism (Nagel 2018)	0.7	1.7	5.2	0.8	1.1	2.3	-1.3	-1.2	0.5
Major Depression (MDD)	0.7	0.8	4.2	2.1	0.0	0.0	-0.9	0.0	0.0
Mean Putamen Volume	0.7	0.7	1.3	0.8	1.1	0.9	0.7	0.5	1.0
Ulcerative Colitis	0.7	1.0	2.4	1.5	-0.8	0.9	-0.3	-1.5	-0.3
Cardiovascular Disease	0.7	2.2	6.8	0.5	-1.7	1.2	1.1	-2.6	0.5
Angina	0.7	0.9	1.9	-0.6	-1.4	-0.8	0.3	-1.2	-1.1
Pack years adult smoking proportion	0.7	1.0	2.3	0.8	0.6	0.8	1.5	0.8	1.3
Qualifications: CSEs or equivalent	0.7	0.9	1.7	-0.8	-1.3	-0.7	-0.5	-0.9	-1.3
High blood pressure	0.7	1.9	5.6	-0.8	-1.7	1.4	0.3	-2.4	0.3
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.4	-0.2	0.4	-0.5	1.3	2.5	0.5
Stomach or abdominal pain in last month	0.7	0.8	2.3	0.4	-0.8	-0.6	-1.5	-0.5	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.3	0.7	-0.0	0.9	-1.5	-1.4	-0.7
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.9	-1.2	-0.8	-1.4	-0.5	0.1	-1.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.2	-0.1	1.5	-0.6	-1.0	1.8	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.3	-0.5	-0.1	-1.1	-1.2	1.1	-1.1
Eye problems/disorders: None of the above	0.7	0.8	3.5	-0.4	0.2	0.1	-1.9	-0.4	-0.8
Medication for pain relief, constipation, heartburn	0.7	1.2	2.5	-0.9	0.6	-1.3	-1.2	1.6	-0.2
Heart disease (mother)	0.7	0.8	3.4	1.2	-0.4	0.1	1.8	0.1	0.5
Age at last live birth	0.7	1.0	2.2	-0.7	-0.7	-1.0	-0.5	-1.2	-1.5
Osteoarthritis (self-reported)	0.7	0.9	2.1	-0.8	-0.6	-0.5	-1.5	-0.7	-1.1
Average weekly champagne plus white wine intake	0.7	1.0	4.8	0.1	0.0	0.2	-2.2	-0.7	-0.7
Commuting to job workplace: Public transport	0.7	0.9	2.7	-0.4	0.8	-0.7	-1.1	1.6	0.3
Risk taking	0.7	1.1	3.2	0.6	1.8	1.0	-0.7	1.0	0.8
Myopia	0.7	1.1	3.3	0.6	0.6	1.8	-0.7	-0.6	1.3
Heart disease (siblings)	0.7	0.9	1.7	0.7	-1.3	-0.6	1.0	-0.8	-1.0
Ulcerative Colitis (UC)	0.6	1.0	2.2	1.3	-1.1	0.6	-0.8	-1.5	-0.3
Lupus	0.6	1.0	2.2	0.6	-0.7	0.6	-1.5	-1.4	-0.5
Neuroticism (2016)	0.6	0.8	2.3	1.4	0.1	0.8	-1.5	-0.3	0.2
Blood Red Count	0.6	5.9	15.1	0.0	1.1	0.1	2.5	3.9	3.6
Heel T-Score	0.6	4.7	14.1	-1.4	-1.6	-3.8	1.0	3.0	0.1
Ever had hysterectomy (womb removed)	0.6	0.7	2.5	-1.6	-0.4	-1.1	0.5	0.3	0.1
Sitting height	0.6	4.1	12.1	-3.5	-0.6	-2.7	-1.9	0.9	-0.9
Allergy	0.6	1.4	4.2	1.1	0.4	1.2	-1.1	-2.0	0.0
Falls in the last year	0.6	0.8	2.1	-1.0	0.1	-0.8	-1.4	0.5	-0.8
Exposure to tobacco smoke at home	0.6	0.7	2.6	-1.6	-0.5	-0.5	-0.5	-0.6	-0.5
Comparative body size at age 10	0.6	1.7	4.0	-1.7	-1.1	-2.0	0.1	-0.0	-1.4
Medication: Blood pressure	0.6	1.1	2.8	-0.8	-1.4	0.4	0.8	-1.7	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.1	0.7	-1.4	-0.0	0.3	-1.2	-0.2
Smoking status: Current	0.6	0.9	2.7	0.4	-0.9	0.9	1.1	-1.6	-0.3
Medication: Blood pressure	0.6	1.2	2.8	-1.7	-1.2	0.3	-0.8	-1.5	0.0
Medication: Paracetamol	0.6	1.0	2.6	-0.8	-0.4	-0.3	-1.0	-1.2	-1.6
Heart attack/myocardial infarction (self-reported)	0.6	0.7	3.1	0.8	-0.4	-0.3	1.8	-0.3	0.6
Lung FVC	0.5	2.5	11.5	3.4	0.6	1.3	0.8	0.6	0.0
Hand grip strength (left)	0.5	1.3	2.5	1.3	-0.9	0.9	-1.3	-1.6	-0.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.6	-0.5	-1.3	-0.3	-0.8	-0.6	-0.9
Impedance of leg (right)	0.5	2.5	6.2	1.2	2.5	2.0	0.2	0.5	1.8
Current tobacco smoking	0.5	0.9	2.7	-0.2	-1.2	0.6	0.5	-1.6	-0.5
Average weekly fortified wine intake	0.5	0.6	2.5	0.3	0.6	-0.4	0.4	1.6	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.3	-0.0	0.3	-1.2	1.1	1.8	0.9
Medication: Atenolol	0.5	0.6	1.2	0.8	-0.1	0.8	1.1	0.3	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.5	0.2	-0.1	-1.5	0.8	1.9	0.9
Heart attack	0.5	0.7	2.8	0.7	-0.2	-0.2	1.7	-0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.0	0.7	-0.6	-1.3	-2.0	-0.5	-1.5
Medication: Amlodipine	0.5	0.7	2.8	0.5	-0.1	1.7	0.6	-0.8	0.5
High blood pressure (siblings)	0.5	0.7	2.5	-0.2	0.4	1.1	0.3	0.8	1.6
Angina (self-reported)	0.5	0.6	1.4	-0.1	-1.2	-0.5	0.7	-1.0	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.0	-0.3	-1.4	-0.3	1.1	-0.6	-0.2
Illnesses of siblings: Diabetes	0.5	0.7	2.9	1.7	-0.6	0.3	0.4	0.4	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.0	-0.9	1.0	0.2	-1.0	-0.1	-0.4
Financial situation satisfaction	0.5	0.6	1.1	-0.7	1.0	0.8	0.2	0.6	1.1
Pain experienced in last month	0.5	0.8	3.1	-0.8	-0.8	-1.8	-0.4	0.3	0.1
Age at First Birth	0.4	0.6	2.1	-0.5	0.5	0.1	0.1	1.5	1.1
LDL Cholesterol	0.4	0.6	1.1	0.7	-0.8	-0.5	0.5	-0.8	-1.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.8	0.4	0.4	0.9	-0.1	0.3	1.4
Blood White Count	0.4	3.1	7.5	2.7	-1.2	1.1	-1.3	-2.7	0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.4	0.9	-0.4	0.8	1.0	-0.4	1.2
Chronotype (morning person)	0.4	0.9	2.8	0.6	0.6	0.2	1.3	-0.1	1.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	0.7	0.7	1.1	0.0	-0.5	0.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.3	-0.3	-0.2	-0.4	-1.5	-0.7	-0.1
Hearing difficulty/problems with background noise	0.4	0.7	1.7	1.3	0.6	1.1	0.6	0.5	0.3
Qualifications: None of the above	0.4	0.8	2.5	-0.0	0.4	1.6	-0.2	-1.3	-0.7
Diabetes (self-reported)	0.4	0.7	2.4	-0.2	-1.5	-0.6	0.3	-1.0	-0.4
Father’s age at death	0.4	0.5	1.8	0.3	0.9	-0.6	0.1	1.4	0.2
Hair/balding pattern: Pattern 3	0.4	0.5	1.2	0.2	1.1	0.1	0.7	0.9	0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.5	0.7	-0.7	-1.3	-1.9	-0.5	-1.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.5	-0.1	0.4	-1.6	-1.4	0.9	0.2
Standing height	0.4	4.0	11.4	-3.1	0.2	-1.6	-3.4	-0.1	-0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	0.1	-1.0	-1.2	-0.8	0.7	-0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	1.0	0.1	0.3	-0.5	0.9	1.0
Age at first live birth	0.4	0.7	1.7	-0.3	1.3	-0.7	-1.0	0.9	0.6
Medication: Ibuprofen	0.4	0.5	0.8	0.3	0.9	0.8	0.9	-0.2	0.5
Medication: Seretide 50 evohaler	0.4	0.4	1.2	-0.3	-0.2	-0.4	1.0	1.1	0.1
Overall health rating	0.4	0.8	2.0	-0.4	-0.5	1.4	1.2	-1.0	0.3
Family relationship satisfaction	0.4	0.5	1.4	1.2	0.8	0.3	0.3	0.8	0.1
Breast Cancer	0.3	0.6	2.8	1.7	-0.9	0.4	0.3	-0.1	-0.2
Ovarian Cancer	0.3	0.4	1.1	1.0	-0.4	0.2	-0.7	-0.7	-0.6
Triglycerides	0.3	0.6	1.3	-1.1	-1.0	-0.1	-0.6	-0.6	0.4
Height	0.3	5.0	18.5	-4.3	-0.0	-1.9	-2.4	-0.3	-1.3
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	1.1	0.1	0.1	-0.8	-0.9	-0.0
Hearing difficulty/problems: Yes	0.3	0.4	1.1	-0.5	0.8	1.1	-0.0	0.2	0.5
Systolic blood pressure, automated reading	0.3	1.0	4.2	-2.0	-0.5	0.3	0.7	-0.5	0.7
Hand grip strength (right)	0.3	0.7	1.6	0.8	-1.1	-0.2	-0.9	-1.3	-0.3
Supplements: Glucosamine	0.3	0.4	1.4	0.3	0.9	0.0	0.3	1.2	0.3
Pain all over the body in last month	0.3	0.3	1.5	1.2	0.1	0.5	-0.1	-0.2	-0.3
Illnesses of siblings	0.3	0.4	1.2	-0.5	1.1	-0.3	-0.9	0.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.5	0.2	0.7	1.2	0.5	-0.4	0.5
Lung cancer (father)	0.3	0.4	0.9	-0.9	-0.2	-0.8	0.8	0.4	-0.3
Headache pain in last month	0.3	0.4	1.2	0.9	0.1	1.1	0.6	0.4	0.4
Supplements: Vitamin C	0.3	0.4	1.1	0.9	0.1	0.3	1.1	0.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.8	1.7	-0.2	-0.9	-0.2	0.1	-0.8
Alcohol drinker status: Previous	0.3	0.4	1.4	0.5	-0.1	-0.3	1.2	0.4	0.6
Impedance of whole body	0.3	1.4	3.7	1.3	1.9	1.4	-0.3	0.2	1.0
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.4	-0.1	-0.2	-0.7	0.6	0.3
Respiratory disease	0.2	0.4	0.9	-0.6	-0.7	-0.8	0.3	0.9	0.2
Hair Pigment	0.2	4.6	17.4	-1.2	-0.5	0.0	-4.2	-2.1	-2.0
Average weekly spirits intake	0.2	0.2	0.5	0.7	0.5	-0.6	0.1	0.3	-0.4
Severe depression (siblings)	0.2	0.2	0.5	-0.1	0.0	-0.3	0.7	0.6	0.1
Townsend deprivation index at recruitment	0.2	0.2	0.9	-0.5	-0.1	0.1	0.0	-1.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.1	-0.2	0.3	0.5	-0.1	-1.1	-0.6
Serious illness, injury or assault to yourself	0.2	0.3	0.9	-0.5	0.0	0.4	-0.9	0.3	0.7
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	-0.1	-0.6	-0.6	0.9	0.1	-0.6
Forced vital capacity (FVC)	0.2	0.8	2.4	1.6	0.9	-0.1	-1.3	0.4	-0.1
Financial difficulties in last 2 years	0.2	0.3	1.5	0.4	0.4	1.2	0.1	-0.3	0.2
Loud music exposure frequency	0.2	0.3	1.0	-1.0	0.1	0.2	-0.7	0.0	0.1
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.7	0.5	0.7	-0.2	-0.1	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	2.2	1.5	0.5	-0.2	-1.4	0.0	-0.2
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	0.0	0.2	0.1	1.0	1.1	0.6
Neck or shoulder pain in last month	0.2	0.3	0.6	0.8	0.3	0.5	0.4	0.6	-0.6
Suffer from ‘nerves’	0.2	0.4	1.0	-0.6	-0.6	-0.1	-0.5	-1.0	-0.5
Friendships satisfaction	0.2	0.3	0.9	-0.3	0.4	-0.4	-1.0	0.6	-0.1
Back pain experienced in last month	0.2	0.2	0.8	-0.3	0.5	0.9	0.0	-0.6	0.1
Breast cancer (self-reported)	0.2	0.2	1.2	0.0	-1.1	0.2	0.0	-0.5	-0.1
Medication: Gliclazide	0.2	0.2	0.5	-0.3	-0.7	-0.1	0.5	-0.1	0.4
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.0	-0.8	-0.5	0.1	-0.2	-0.6
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	0.2	-0.5	-0.7	-0.1	-0.2	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.8	-0.9	0.3	0.5	-0.3	-0.3	-0.4
Fasting Glucose	0.1	0.1	0.3	-0.6	-0.0	-0.2	-0.1	0.4	-0.0
Tanning	0.1	1.6	7.4	0.3	-0.2	-1.2	2.7	0.7	0.0
Impedance of arm (right)	0.1	0.7	2.4	0.2	0.6	0.2	-1.5	-0.9	-0.6
Happiness	0.1	0.2	0.3	-0.2	-0.6	-0.4	-0.6	-0.3	0.0
Noisy workplace	0.1	0.1	0.4	-0.2	-0.0	0.5	0.6	-0.0	0.1
Impedance of arm (left)	0.1	0.6	2.2	0.1	1.0	0.1	-1.5	-0.2	-0.0
Comparative height size at age 10	0.1	0.7	1.5	-0.5	1.2	0.3	-0.2	1.0	1.2
Ever had bowel cancer screening	0.1	0.1	0.2	0.0	-0.2	0.3	0.5	-0.0	-0.2
Commuting to job workplace: Walk	0.1	0.2	0.3	-0.5	-0.2	-0.5	0.1	0.3	-0.5
Diastolic blood pressure, automated reading	0.1	0.5	1.3	-0.9	-0.2	0.1	-0.4	0.7	1.1
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.0	-0.2	0.2	-0.3	-0.5	0.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.6	-0.2	-0.8	-0.1	0.4	-0.3	0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.4	-0.3	-0.3	0.3	0.0	0.1
Medication: Omeprazole	0.0	0.1	0.2	-0.1	-0.4	0.1	0.1	-0.0	0.3

Hub : Genes

FKBP2

Models

Trait associations