TWAS hub - FLOT2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.0922	0.0418	0.00380	-0.002	NA	0.042	NA	-0.001	5.4e-01	NA	0.00033	NA	0.43000
2	TCGA	Brain Lower Grade Glioma	0.0363	0.0224	0.00061	0.035	0.032	0.031	NA	0.029	6.6e-05	0.00013	0.00015	NA	0.00025

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Mouth/teeth dental problems: Bleeding gums	7.5	9.8	19.2	-0.6	-4.4
Blood Red Count	6.8	65.8	108.2	-4.8	-10.4
LDL Cholesterol	6.5	10.3	14.6	-2.4	-3.8
Number of children fathered	6.1	6.9	6.9	2.6	2.6
HbA1C	5.7	6.3	12.3	-0.5	-3.5
Medication: Atenolol	5.7	7.1	10.2	-2.0	-3.2
Heart disease (siblings)	5.7	7.0	12.6	-1.2	-3.5
Ever used hormone-replacement therapy (HRT)	4.6	5.9	10.0	1.3	3.2
Blood Platelet Count	4.4	51.3	86.9	-9.3	-4.0
Severe depression (siblings)	4.3	4.8	8.2	1.2	-2.9
Waist circumference	4.3	15.6	18.0	-4.2	-3.6
Mouth/teeth dental problems	4.0	6.1	10.5	1.3	3.2
Cardiovascular Disease	3.9	12.8	20.5	-2.3	-4.5
Respiratory disease	3.7	8.2	14.5	1.4	3.8
Medication: Cholesterol lowering	3.7	5.7	11.2	0.4	-3.4
Number of incorrect matches in round	3.6	5.9	10.9	1.0	-3.3
Medication: Simvastatin	3.6	5.3	10.6	-0.1	-3.2
Hayfever/allergic rhinitis (self-reported)	3.5	4.6	9.1	0.4	3.0
Number of full sisters	3.5	4.3	6.1	1.6	2.5
Asthma (self-reported)	3.5	6.9	10.8	1.7	3.3
Alzheimer’s Disease (in mother)	3.4	4.0	6.9	2.6	1.0
Tinnitus: Yes, but not now, but have in the past	3.3	3.5	5.8	-1.1	-2.4
Ever unenthusiastic/disinterested for a whole week	3.3	4.0	5.7	-1.5	-2.4
Pulse rate	3.3	5.6	6.4	2.5	2.2
Heart attack	3.1	3.9	7.8	-0.2	-2.8
Illnesses of siblings	3.1	4.3	8.3	0.6	2.9
Asthma	3.0	5.9	8.9	1.7	3.0
Hearing difficulty/problems: Yes	2.9	4.4	4.8	2.0	2.2
Leg fat percentage (right)	2.8	10.3	11.4	-3.0	-3.4
Leg fat mass (right)	2.8	10.7	12.7	-3.6	-2.9
Past tobacco smoking	2.7	5.0	8.4	1.3	2.9
Medication for cholesterol, blood pressure or diabetes	2.7	4.6	9.1	0.1	3.0
Shortness of breath walking on level ground	2.7	3.2	3.3	-1.8	-1.8
Cholesterol lowering medication	2.7	4.0	5.9	-1.4	-2.4
BMI	2.6	15.0	16.7	-3.6	-4.1
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	4.7	-1.0	-2.2
Leg fat percentage (left)	2.6	9.5	9.9	-3.0	-3.1
Angina	2.5	3.3	3.5	-1.7	-1.9
Hip circumference	2.5	10.8	18.5	-4.3	-1.8
Prospective memory result	2.5	3.0	4.7	-1.2	-2.2
Whole body fat mass	2.5	10.4	16.6	-4.1	-2.0
Pulse rate, automated reading	2.5	8.2	12.8	3.6	1.9
High cholesterol (Self-reported)	2.5	4.4	7.5	-1.2	-2.7
Risk taking	2.5	3.6	6.9	2.6	0.6
Leg fat mass (left)	2.5	9.9	12.3	-3.5	-2.7
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	3.9	1.5	-2.0
Angina (self-reported)	2.4	3.1	3.3	-1.7	-1.8
Smoking status: Previous	2.4	3.6	5.7	-1.2	-2.4
Ever taken oral contraceptive pill	2.4	2.7	3.4	-1.4	-1.9
Heart attack/myocardial infarction (self-reported)	2.4	3.1	6.1	-0.2	-2.5
Trunk fat mass	2.3	9.9	18.1	-4.3	-1.3
Arm fat mass (right)	2.3	9.3	15.6	-4.0	-1.7
Medication: Blood pressure	2.3	4.0	7.6	-0.5	-2.8
Smoking Status	2.2	5.2	10.5	0.2	-3.2
Medication: Gliclazide	2.2	2.5	2.9	-1.7	-1.4
Arm fat mass (left)	2.2	8.9	14.9	-3.9	-1.7
Medication: Blood pressure	2.2	4.2	4.7	-1.9	-2.2
Arm fat percentage (right)	2.1	8.1	13.8	-3.7	-1.6
Body fat percentage	2.1	8.3	13.1	-3.6	-1.9
Trunk fat percentage	2.0	8.2	15.1	-3.9	-1.2
Hayfever, allergic rhinitis or eczema	2.0	4.3	8.1	-0.6	2.9
Weight	2.0	9.7	16.9	-4.1	-1.6
Health satisfaction	2.0	2.6	2.6	-1.6	-1.6
Average weekly champagne plus white wine intake	2.0	2.7	3.0	-1.6	-1.7
Ever smoked	2.0	3.6	5.6	-1.2	-2.4
Alcohol drinker status: Previous	2.0	2.2	4.3	2.1	0.5
Medication: Ramipril	1.9	2.5	4.4	-0.8	-2.1
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	4.2	2.0	-0.7
Arm fat percentage (left)	1.9	7.7	13.0	-3.6	-1.5
Commuting to job workplace: Walk	1.9	2.1	3.9	2.0	-0.5
Tinnitus: Yes, now most or all of the time	1.9	2.2	4.2	0.4	2.1
Unable to work because of sickness or disability	1.9	2.4	4.3	2.1	-0.7
Vascular/heart problems diagnosed by doctor	1.9	5.3	9.3	1.1	3.0
Verbal and Numeric Reasoning (VNR)	1.8	4.3	5.6	-1.7	2.4
Fasting Glucose	1.8	2.2	3.1	-1.8	-1.1
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	3.4	1.8	0.9
Allergy	1.8	4.3	8.0	0.7	-2.8
Birth weight of first child	1.8	3.2	5.3	-1.1	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.7	-1.9	0.7
Osteoarthritis (self-reported)	1.8	2.3	3.2	1.2	-1.8
Ever depressed for a whole week	1.8	2.2	4.5	-0.0	-2.1
Alzheimer’s Disease (including proxy)	1.7	2.5	4.5	2.1	0.8
Allergy or Eczema	1.7	4.4	8.4	-0.7	2.9
Chronic bronchitis/emphysema (father)	1.7	2.0	3.8	-2.0	-0.3
Mouth/teeth dental problems: Loose teeth	1.7	2.0	2.8	-1.1	-1.7
Hypertension (Self-reported)	1.7	4.7	7.6	-1.3	-2.8
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	2.4	-1.4	1.6
Body mass index (BMI)	1.6	6.9	8.2	-2.9	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	3.1	1.4	-1.8
Blood clot in the leg (DVT)	1.6	2.0	2.3	-1.3	1.5
Breast cancer (self-reported)	1.6	1.9	3.8	-0.3	-1.9
Mean Putamen Volume	1.5	1.8	3.4	-0.4	-1.8
High blood pressure	1.5	4.3	6.3	-1.5	-2.5
Alcohol intake versus 10 years previously	1.5	2.2	4.3	-0.2	-2.1
Father’s age at death	1.5	2.0	4.0	-0.1	2.0
Depression (self-reported)	1.5	1.8	2.5	1.6	1.1
Mean time to correctly identify matches	1.5	3.0	5.9	-2.4	-0.0
Major Depression (MDD)	1.4	1.7	1.9	1.4	-1.2
Waist Hip Ratio (WHR)	1.4	6.3	10.0	-1.6	-3.2
Qualifications: CSEs or equivalent	1.4	1.9	2.3	1.2	-1.5
Comparative body size at age 10	1.4	4.0	6.7	-1.1	2.6
Eye problems/disorders: None of the above	1.4	1.7	3.3	-0.1	1.8
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.5	0.4	1.9
Body Mass Index (BMI) (2010)	1.3	1.7	3.3	-1.8	-0.5
Relative age of first facial hair	1.3	2.6	4.6	-2.1	-0.8
Systolic blood pressure, automated reading	1.3	3.8	7.1	0.7	-2.7
Leg fat-free mass (left)	1.3	6.6	13.2	-3.6	-0.0
Fluid intelligence score	1.3	2.8	2.8	-1.6	1.7
Impedance of arm (right)	1.3	6.0	12.0	-0.3	3.5
Forced vital capacity (FVC), Best measure	1.3	4.7	9.1	0.5	3.0
Supplements: Vitamin C	1.3	1.5	3.0	-1.7	-0.2
Multivitamins +/- minerals	1.2	1.5	2.6	0.6	1.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	1.5	1.2	1.1
Leg predicted mass (left)	1.2	6.3	12.5	-3.5	-0.1
Pulse wave reflection index	1.2	1.5	1.9	-1.4	-1.0
Medication: Seretide 50 evohaler	1.2	1.4	1.9	0.9	1.4
Heart disease (mother)	1.2	1.5	2.0	-1.0	-1.4
Leg pain on walking	1.2	1.5	1.9	1.0	-1.4
Average weekly red wine intake	1.2	1.7	3.4	1.8	0.2
Mother’s age at death	1.2	1.5	2.9	-1.7	0.1
Commuting to job workplace: Public transport	1.2	1.4	1.5	-1.2	-1.2
Arm predicted mass (left)	1.2	6.1	7.8	-2.8	-2.1
Medication for hormone replacement therapy	1.1	1.2	2.4	1.6	-0.1
Medication: Co-codamol	1.1	1.3	2.5	-0.0	-1.6
Impedance of arm (left)	1.1	5.0	10.0	-0.2	3.2
Hair/balding pattern: Pattern 4	1.1	2.7	4.5	-2.1	-1.0
Headache pain in last month	1.1	1.9	3.8	-0.1	2.0
Worry too long after embarrassment	1.1	1.8	3.1	0.7	1.8
Leg fat-free mass (right)	1.1	5.7	11.4	-3.4	0.3
Leg predicted mass (right)	1.1	5.6	11.2	-3.3	0.3
Basal metabolic rate	1.1	6.2	11.2	-3.4	-1.1
Age started oral contraceptive pill	1.1	1.4	1.7	-1.0	-1.3
Intelligence (Savage-Jansen 2018)	1.0	3.0	3.9	-2.0	1.4
Chronotype (morning person)	1.0	2.4	4.5	-0.5	-2.1
Townsend deprivation index at recruitment	1.0	1.4	2.4	0.7	-1.5
Serious illness, injury or assault to yourself	1.0	1.2	2.3	0.3	-1.5
Sitting height	1.0	7.3	14.7	-0.2	3.8
Worrier / anxious feelings	1.0	1.9	2.7	-1.1	-1.6
Illnesses of mother	1.0	1.3	2.4	0.3	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	6.5	-0.2	2.5
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.2	0.5	1.5
Overall health rating	1.0	2.0	3.6	-0.7	-1.9
Age at last live birth	1.0	1.5	2.1	0.9	-1.4
Whole body fat-free mass	1.0	5.5	10.1	-3.2	-0.9
Loneliness, isolation	1.0	1.4	2.7	1.7	-0.3
Long-standing illness, disability or infirmity	1.0	1.5	2.9	0.2	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.2	0.2	-1.8
Bipolar Disorder (2018)	0.9	1.5	2.8	1.7	-0.4
Ever had hysterectomy (womb removed)	0.9	1.0	1.7	1.3	-0.6
Stomach or abdominal pain in last month	0.9	1.1	2.2	-0.2	-1.5
High blood pressure (mother)	0.9	1.2	2.1	-0.6	-1.4
Had menopause	0.9	1.1	1.9	-1.4	-0.5
Forced vital capacity (FVC)	0.9	3.6	6.6	0.8	2.6
Pain all over the body in last month	0.9	0.9	1.8	1.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.2	-0.3	1.5
Breastfed as a baby	0.9	1.1	2.0	-1.4	0.5
Loud music exposure frequency	0.9	1.0	1.8	-1.4	-0.3
Gout (self-reported)	0.9	1.3	2.5	1.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.0	-0.4	-1.4
Arm predicted mass (right)	0.9	4.5	6.2	-2.5	-1.7
Family relationship satisfaction	0.9	1.1	2.1	-0.0	-1.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.3	0.0	-1.5
Qualifications: nursing, teaching	0.9	1.5	1.5	1.2	1.2
Illnesses of father: None of the above (group 1)	0.9	1.2	2.2	1.5	0.4
Whole body water mass	0.9	5.3	9.6	-3.1	-1.0
Medication: Atorvastatin	0.9	1.1	1.5	-1.2	-0.9
Arm fat-free mass (left)	0.9	4.6	6.6	-2.6	-1.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.4	0.8	1.2
Breast Cancer	0.8	2.0	2.7	-1.6	-1.1
Schizophrenia (2014)	0.8	1.7	2.4	1.6	-1.0
Sensitivity / hurt feelings	0.8	1.3	2.6	0.1	1.6
Pack years adult smoking proportion	0.8	1.2	1.2	1.1	-1.1
Trunk fat-free mass	0.8	4.6	7.3	-2.7	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	1.9	-0.8	-1.4
Trunk predicted mass	0.8	4.3	7.0	-2.6	-1.3
Length of working week for main job	0.8	0.9	1.7	1.3	-0.1
Tense / ‘highly strung’	0.8	1.3	1.9	1.4	-0.8
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.5	-0.6	-1.2
High blood pressure (siblings)	0.8	1.2	2.2	0.3	-1.5
Arm fat-free mass (right)	0.8	4.1	5.7	-2.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.3	-1.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	1.9	1.2	1.4
Bipolar Disorder or Schizophrenia	0.7	1.7	2.8	1.7	-0.8
Depression (Nagel 2018)	0.7	1.0	1.2	0.9	-1.1
Lupus	0.7	1.0	1.5	1.2	0.7
Blood White Count	0.7	4.8	5.4	2.3	2.1
Systolic Blood Pressure	0.7	3.6	5.6	1.3	-2.4
Hypothyroidism (self reported)	0.7	1.6	1.7	1.2	1.3
Lung FVC	0.7	3.6	6.4	2.5	0.9
Average weekly spirits intake	0.7	0.9	1.2	0.8	1.1
Diabetes (mother)	0.7	0.9	1.4	-0.7	-1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	4.8	0.3	2.2
Happiness	0.7	0.9	1.6	1.3	-0.4
Medication: Lansoprazole	0.7	0.8	1.2	0.6	1.1
Pulse wave Arterial Stiffness index	0.7	0.9	1.7	-0.1	1.3
Standing height	0.7	6.6	9.6	-3.1	1.9
Ever highly irritable/argumentative for 2 days	0.7	0.8	0.8	0.9	0.9
Age at first live birth	0.7	1.3	1.3	1.1	-1.1
Medication for cholesterol	0.7	1.0	1.6	0.7	1.3
Smoking status: Current	0.7	1.1	1.6	0.8	-1.3
Fractured/broken bones in last 5 years	0.7	0.9	1.6	1.3	-0.5
Myopia	0.7	1.0	1.6	0.6	-1.3
Pack years of smoking	0.7	1.0	1.3	0.9	-1.2
Ovarian Cancer	0.6	0.8	1.0	-0.8	-1.0
Height	0.6	11.3	17.1	-4.1	2.4
Number of treatments/medications taken	0.6	1.1	2.3	0.1	-1.5
Current tobacco smoking	0.6	1.0	1.4	0.8	-1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	1.5	-1.2	-1.1
Glaucoma (self-reported)	0.6	0.6	1.2	-0.4	-1.1
Medication: Amlodipine	0.6	0.8	1.5	-0.4	-1.2
Birth weight	0.6	1.3	2.5	-0.5	1.6
Exposure to tobacco smoke outside home	0.6	0.8	0.8	-0.9	-0.9
Emphysema/chronic bronchitis	0.6	0.7	1.1	-1.1	0.5
Comparative height size at age 10	0.6	3.3	3.5	-1.8	1.9
Illnesses of father: Heart disease	0.6	0.8	1.4	-0.5	-1.2
Ever had bowel cancer screening	0.6	0.7	1.3	-1.1	-0.3
Eye problems/disorders: Cataract	0.6	0.7	0.8	-0.9	-0.8
Wears glasses or contact lenses	0.6	0.7	0.8	-0.7	0.9
Crohns Disease (2017)	0.5	1.0	1.9	-0.3	-1.4
Rheumatoid Arthritis	0.5	0.7	1.0	-0.7	1.0
Blood Eosinophil Count	0.5	4.1	8.0	0.5	2.8
Heel T-Score	0.5	3.9	6.2	2.5	1.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	-0.2	-1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.7	0.8	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.3	-0.6	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.2	1.5	0.2
Peak expiratory flow (PEF)	0.5	1.1	1.7	-1.3	-0.7
Alcohol intake frequency.	0.5	1.1	2.1	0.4	-1.4
Chest pain or discomfort	0.5	0.8	1.2	-0.6	-1.1
Medication: Aspirin	0.5	0.6	0.9	-1.0	-0.5
Mineral and other dietary supplements	0.5	0.6	0.9	-1.0	-0.6
Hearing aid user	0.5	0.6	1.0	1.0	0.5
Medication: Bendroflumethiazide	0.5	0.8	0.8	-0.8	-0.9
Number of operations (self-reported)	0.5	0.7	1.5	-1.2	0.1
Average weekly beer plus cider intake	0.5	0.7	0.7	0.8	0.8
Diastolic blood pressure, automated reading	0.5	1.5	2.1	1.4	1.0
Basal cell carcinoma (self-reported)	0.5	0.6	0.9	-0.5	-0.9
Impedance of whole body	0.5	2.6	4.8	0.7	2.2
Neuroticism (Nagel 2018)	0.4	1.0	1.4	1.2	0.8
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	0.3	-0.9
Irritable Bowel Disease (IBD)	0.4	0.9	1.6	-0.5	-1.3
Ulcerative Colitis	0.4	0.5	0.7	-0.6	-0.8
Supplements: Zinc	0.4	0.4	0.8	-0.9	-0.1
Maternal smoking around birth	0.4	0.5	1.0	-1.0	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.0	1.4	0.1
Supplements: Glucosamine	0.4	0.5	1.0	0.2	-1.0
Alcohol usually taken with meals	0.4	0.7	1.3	0.3	-1.1
Hair/balding pattern: Pattern 2	0.4	0.6	0.8	0.6	0.9
Had other major operations	0.4	0.5	1.0	-1.0	0.1
Lung cancer (father)	0.4	0.5	1.0	1.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.4	0.5	1.2
Qualifications: College or University degree	0.4	1.2	2.1	-1.5	0.5
Medication for pain relief, constipation, heartburn	0.4	0.6	1.1	1.0	-0.4
Migraine (self-reported)	0.4	0.5	0.5	0.7	0.7
Medication: Omeprazole	0.4	0.5	1.0	1.0	0.0
Diabetes diagnosed by doctor	0.4	0.6	0.8	0.9	0.6
Friendships satisfaction	0.4	0.5	1.1	1.0	0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	0.8	0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.9	0.4
Depressed Affect (Nagel 2018)	0.3	0.7	1.4	1.2	0.2
Schizophrenia (2018)	0.3	0.6	0.6	0.8	-0.7
Coronary Artery Disease (CAD)	0.3	0.4	0.4	-0.6	0.7
Lung FEV1/FVC ratio	0.3	1.6	2.1	-1.1	-1.4
Impedance of leg (right)	0.3	1.6	3.0	1.7	-0.4
Fed-up feelings	0.3	0.5	0.9	0.4	1.0
Taking other prescription medications	0.3	0.4	0.4	0.7	0.6
Impedance of leg (left)	0.3	1.6	3.0	1.7	-0.4
Diabetes (self-reported)	0.3	0.5	0.7	0.8	0.4
Falls in the last year	0.3	0.3	0.7	-0.2	-0.8
Hair/balding pattern: Pattern 3	0.3	0.5	0.6	-0.6	-0.8
Wheeze or whistling in the chest in last year	0.3	0.5	0.7	0.5	-0.8
Pulse wave peak to peak time	0.3	0.4	0.8	0.1	-0.9
Suffer from ‘nerves’	0.3	0.4	0.6	-0.4	0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	0.2	0.8
Medication: Aspirin	0.3	0.4	0.4	-0.6	-0.6
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	-0.1	-0.8
Alcohol drinker status: Never	0.3	0.3	0.7	-0.8	-0.1
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.2	-0.8
Reaction Time	0.2	0.5	0.8	-0.9	0.3
Crohns Disease (2012)	0.2	0.3	0.6	0.8	0.0
HDL Cholesterol	0.2	0.3	0.6	0.8	0.2
Primary Biliary Cirrhosis	0.2	0.3	0.6	-0.8	-0.2
Triglycerides	0.2	0.3	0.5	0.3	-0.7
Neuroticism	0.2	0.4	0.6	-0.5	0.7
Medication: Levothyroxine sodium	0.2	0.3	0.6	0.3	0.8
Noisy workplace	0.2	0.2	0.5	-0.7	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.2	-0.5	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	-0.3	-0.7
Neck or shoulder pain in last month	0.2	0.2	0.5	0.0	-0.7
Medication: Ibuprofen	0.2	0.2	0.4	-0.1	0.6
Medication: Allopurinol	0.2	0.2	0.3	0.5	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.4	0.6
Back pain experienced in last month	0.2	0.3	0.4	-0.5	0.7
Financial situation satisfaction	0.2	0.2	0.4	-0.6	0.1
Medication: Paracetamol	0.2	0.3	0.5	-0.7	0.2
Irritability	0.2	0.4	0.8	-0.9	-0.1
Worry (Nagel 2018)	0.1	0.2	0.3	0.3	-0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.0	-0.5
Prostate Cancer	0.1	0.1	0.2	0.4	-0.1
Age at First Birth	0.1	0.2	0.2	-0.5	0.4
Bipolar Disorder (2011)	0.1	0.1	0.3	0.5	0.0
Neuroticism (2016)	0.1	0.1	0.1	0.2	-0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	-0.0	-0.4
Tanning	0.1	1.7	3.3	1.8	-0.3
Hand grip strength (left)	0.1	0.2	0.3	0.4	-0.5
Vitamin and mineral supplements	0.1	0.1	0.2	0.3	-0.4
Medication: Metformin	0.1	0.1	0.1	-0.4	0.3
Hand grip strength (right)	0.1	0.2	0.4	0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	0.0	-0.5
Relative age voice broke	0.1	0.1	0.2	0.2	0.5
Age when periods started (menarche)	0.1	0.2	0.3	0.2	-0.6
Nervous feelings	0.1	0.2	0.4	-0.2	-0.6
Time employed in main current job	0.1	0.1	0.2	-0.2	0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.4	0.1
Medication: Paracetamol	0.1	0.2	0.3	-0.6	0.4
Number of full brothers	0.1	0.1	0.2	-0.5	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.2	-0.4
Had major operations	0.1	0.1	0.2	0.2	-0.5
Knee pain experienced in last month	0.1	0.1	0.2	0.4	-0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.1	-0.3	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.2	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.0	-0.7
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.0	-0.5
Pain experienced in last month	0.1	0.1	0.2	0.1	-0.4
Supplements: Calcium	0.1	0.1	0.1	-0.1	-0.4
Ulcerative Colitis (UC)	0.0	0.0	0.0	-0.1	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.2	-0.0
Hair Pigment	0.0	0.5	1.0	-0.1	-1.0
Diabetes (father)	0.0	0.0	0.1	-0.3	0.2
Average weekly fortified wine intake	0.0	0.1	0.1	-0.3	0.1
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.2	-0.4
Qualifications: None of the above	0.0	0.1	0.1	-0.3	0.2
Financial difficulties in last 2 years	0.0	0.0	0.0	0.2	0.1
Neuroticism score	0.0	0.1	0.1	-0.2	0.3
Number of live births	0.0	0.0	0.0	0.2	-0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	-0.1	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	-0.2	0.1
Mood swings	0.0	0.0	0.1	0.1	0.3
Osteoporosis (self-reported)	0.0	0.0	0.1	-0.2	0.1
Miserableness	0.0	0.0	0.1	-0.2	0.0
Guilty feelings	0.0	0.0	0.0	-0.2	-0.0
Medication: Lisinopril	0.0	0.0	0.1	-0.1	-0.2

Hub : Genes

FLOT2

Models

Trait associations