Hub : Genes

FLOT2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.0922 0.0418 0.00380 -0.002 NA 0.042 NA -0.001 5.4e-01 NA 0.00033 NA 0.43000
2 TCGA Brain Lower Grade Glioma 0.0363 0.0224 0.00061 0.035 0.032 0.031 NA 0.029 6.6e-05 0.00013 0.00015 NA 0.00025

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.5 2.8 1.7 -0.4
Bipolar Disorder or Schizophrenia 0.7 1.7 2.8 1.7 -0.8
Depressed Affect (Nagel 2018) 0.3 0.7 1.4 1.2 0.2
Depression (Nagel 2018) 0.7 1.0 1.2 0.9 -1.1
Intelligence (Savage-Jansen 2018) 1.0 3.0 3.9 -2.0 1.4
Neuroticism (Nagel 2018) 0.4 1.0 1.4 1.2 0.8
Schizophrenia (2018) 0.3 0.6 0.6 0.8 -0.7
Schizophrenia vs Biploar Disorder 0.4 0.5 0.9 0.3 -0.9
Worry (Nagel 2018) 0.1 0.2 0.3 0.3 -0.6
Alzheimer’s Disease (in mother) 3.4 4.0 6.9 2.6 1.0
Alzheimer’s Disease (in father) 0.1 0.1 0.3 -0.0 -0.5
Alzheimer’s Disease (including proxy) 1.7 2.5 4.5 2.1 0.8
Crohns Disease (2017) 0.5 1.0 1.9 -0.3 -1.4
Irritable Bowel Disease (IBD) 0.4 0.9 1.6 -0.5 -1.3
Ulcerative Colitis (UC) 0.0 0.0 0.0 -0.1 -0.1
Major Depression (MDD) 1.4 1.7 1.9 1.4 -1.2
Reaction Time 0.2 0.5 0.8 -0.9 0.3
Verbal and Numeric Reasoning (VNR) 1.8 4.3 5.6 -1.7 2.4
Breast Cancer 0.8 2.0 2.7 -1.6 -1.1
Ovarian Cancer 0.6 0.8 1.0 -0.8 -1.0
Prostate Cancer 0.1 0.1 0.2 0.4 -0.1
Age at First Birth 0.1 0.2 0.2 -0.5 0.4
Bipolar Disorder (2011) 0.1 0.1 0.3 0.5 0.0
Body Mass Index (BMI) (2010) 1.3 1.7 3.3 -1.8 -0.5
Coronary Artery Disease (CAD) 0.3 0.4 0.4 -0.6 0.7
Crohns Disease (2012) 0.2 0.3 0.6 0.8 0.0
Mean Putamen Volume 1.5 1.8 3.4 -0.4 -1.8
Fasting Glucose 1.8 2.2 3.1 -1.8 -1.1
HbA1C 5.7 6.3 12.3 -0.5 -3.5
HDL Cholesterol 0.2 0.3 0.6 0.8 0.2
LDL Cholesterol 6.5 10.3 14.6 -2.4 -3.8
Lupus 0.7 1.0 1.5 1.2 0.7
Neuroticism (2016) 0.1 0.1 0.1 0.2 -0.3
Primary Biliary Cirrhosis 0.2 0.3 0.6 -0.8 -0.2
Rheumatoid Arthritis 0.5 0.7 1.0 -0.7 1.0
Schizophrenia (2014) 0.8 1.7 2.4 1.6 -1.0
Triglycerides 0.2 0.3 0.5 0.3 -0.7
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.1 -0.0 -0.4
Ulcerative Colitis 0.4 0.5 0.7 -0.6 -0.8
Blood Eosinophil Count 0.5 4.1 8.0 0.5 2.8
Blood Platelet Count 4.4 51.3 86.9 -9.3 -4.0
Blood Red Count 6.8 65.8 108.2 -4.8 -10.4
Blood White Count 0.7 4.8 5.4 2.3 2.1
Heel T-Score 0.5 3.9 6.2 2.5 1.3
BMI 2.6 15.0 16.7 -3.6 -4.1
Height 0.6 11.3 17.1 -4.1 2.4
Waist Hip Ratio (WHR) 1.4 6.3 10.0 -1.6 -3.2
Systolic Blood Pressure 0.7 3.6 5.6 1.3 -2.4
Smoking Status 2.2 5.2 10.5 0.2 -3.2
Allergy or Eczema 1.7 4.4 8.4 -0.7 2.9
Cardiovascular Disease 3.9 12.8 20.5 -2.3 -4.5
Hypothyroidism (self reported) 0.7 1.6 1.7 1.2 1.3
Respiratory disease 3.7 8.2 14.5 1.4 3.8
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.0 -0.2 -0.0
Lung FEV1/FVC ratio 0.3 1.6 2.1 -1.1 -1.4
Lung FVC 0.7 3.6 6.4 2.5 0.9
Neuroticism 0.2 0.4 0.6 -0.5 0.7
Chronotype (morning person) 1.0 2.4 4.5 -0.5 -2.1
Hair Pigment 0.0 0.5 1.0 -0.1 -1.0
Tanning 0.1 1.7 3.3 1.8 -0.3
Hand grip strength (left) 0.1 0.2 0.3 0.4 -0.5
Number of treatments/medications taken 0.6 1.1 2.3 0.1 -1.5
Average weekly spirits intake 0.7 0.9 1.2 0.8 1.1
Sensitivity / hurt feelings 0.8 1.3 2.6 0.1 1.6
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.3 -0.2 -1.1
Hearing difficulty/problems: Yes 2.9 4.4 4.8 2.0 2.2
Relative age of first facial hair 1.3 2.6 4.6 -2.1 -0.8
Other serious medical condition/disability diagnosed by doctor 2.4 3.1 3.9 1.5 -2.0
Ever used hormone-replacement therapy (HRT) 4.6 5.9 10.0 1.3 3.2
Ever had hysterectomy (womb removed) 0.9 1.0 1.7 1.3 -0.6
Systolic blood pressure, automated reading 1.3 3.8 7.1 0.7 -2.7
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 0.7 0.8 0.6
Angina 2.5 3.3 3.5 -1.7 -1.9
Medication for hormone replacement therapy 1.1 1.2 2.4 1.6 -0.1
Vitamin and mineral supplements 0.1 0.1 0.2 0.3 -0.4
Supplements: Zinc 0.4 0.4 0.8 -0.9 -0.1
Medication: Co-codamol 1.1 1.3 2.5 -0.0 -1.6
Medication: Metformin 0.1 0.1 0.1 -0.4 0.3
Diabetes (father) 0.0 0.0 0.1 -0.3 0.2
Diabetes (mother) 0.7 0.9 1.4 -0.7 -1.2
Severe depression (siblings) 4.3 4.8 8.2 1.2 -2.9
Pack years adult smoking proportion 0.8 1.2 1.2 1.1 -1.1
Impedance of leg (right) 0.3 1.6 3.0 1.7 -0.4
Leg fat-free mass (left) 1.3 6.6 13.2 -3.6 -0.0
Trunk fat percentage 2.0 8.2 15.1 -3.9 -1.2
Hand grip strength (right) 0.1 0.2 0.4 0.6 -0.3
Townsend deprivation index at recruitment 1.0 1.4 2.4 0.7 -1.5
Current tobacco smoking 0.6 1.0 1.4 0.8 -1.2
Average weekly fortified wine intake 0.0 0.1 0.1 -0.3 0.1
Maternal smoking around birth 0.4 0.5 1.0 -1.0 -0.1
Fed-up feelings 0.3 0.5 0.9 0.4 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.3 0.0 -0.5
Relative age voice broke 0.1 0.1 0.2 0.2 0.5
Taking other prescription medications 0.3 0.4 0.4 0.7 0.6
Age when periods started (menarche) 0.1 0.2 0.3 0.2 -0.6
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 3.4 1.8 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.0 1.4 0.1
Tinnitus: Yes, but not now, but have in the past 3.3 3.5 5.8 -1.1 -2.4
Qualifications: CSEs or equivalent 1.4 1.9 2.3 1.2 -1.5
Serious illness, injury or assault to yourself 1.0 1.2 2.3 0.3 -1.5
High blood pressure 1.5 4.3 6.3 -1.5 -2.5
Hayfever, allergic rhinitis or eczema 2.0 4.3 8.1 -0.6 2.9
Multivitamins +/- minerals 1.2 1.5 2.6 0.6 1.6
Stomach or abdominal pain in last month 0.9 1.1 2.2 -0.2 -1.5
Supplements: Glucosamine 0.4 0.5 1.0 0.2 -1.0
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 1.5 1.2 1.1
Medication: Atenolol 5.7 7.1 10.2 -2.0 -3.2
Medication: Levothyroxine sodium 0.2 0.3 0.6 0.3 0.8
Sitting height 1.0 7.3 14.7 -0.2 3.8
Chronic bronchitis/emphysema (father) 1.7 2.0 3.8 -2.0 -0.3
High blood pressure (mother) 0.9 1.2 2.1 -0.6 -1.4
Body mass index (BMI) 1.6 6.9 8.2 -2.9 -2.4
Impedance of leg (left) 0.3 1.6 3.0 1.7 -0.4
Leg predicted mass (left) 1.2 6.3 12.5 -3.5 -0.1
Trunk fat mass 2.3 9.9 18.1 -4.3 -1.3
Waist circumference 4.3 15.6 18.0 -4.2 -3.6
Number of incorrect matches in round 3.6 5.9 10.9 1.0 -3.3
Past tobacco smoking 2.7 5.0 8.4 1.3 2.9
Alcohol usually taken with meals 0.4 0.7 1.3 0.3 -1.1
Nervous feelings 0.1 0.2 0.4 -0.2 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.3 -0.6 -1.1
Hearing difficulty/problems with background noise 0.0 0.1 0.1 0.2 -0.4
Hair/balding pattern: Pattern 2 0.4 0.6 0.8 0.6 0.9
Had menopause 0.9 1.1 1.9 -1.4 -0.5
Had other major operations 0.4 0.5 1.0 -1.0 0.1
Forced vital capacity (FVC) 0.9 3.6 6.6 0.8 2.6
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.2 1.5 0.2
Ever unenthusiastic/disinterested for a whole week 3.3 4.0 5.7 -1.5 -2.4
Qualifications: None of the above 0.0 0.1 0.1 -0.3 0.2
Financial difficulties in last 2 years 0.0 0.0 0.0 0.2 0.1
Mouth/teeth dental problems 4.0 6.1 10.5 1.3 3.2
Heart attack 3.1 3.9 7.8 -0.2 -2.8
Allergy 1.8 4.3 8.0 0.7 -2.8
Pain all over the body in last month 0.9 0.9 1.8 1.4 -0.2
Diabetes (self-reported) 0.3 0.5 0.7 0.8 0.4
Hayfever/allergic rhinitis (self-reported) 3.5 4.6 9.1 0.4 3.0
Medication: Ramipril 1.9 2.5 4.4 -0.8 -2.1
Medication: Simvastatin 3.6 5.3 10.6 -0.1 -3.2
Fluid intelligence score 1.3 2.8 2.8 -1.6 1.7
Illnesses of siblings 3.1 4.3 8.3 0.6 2.9
Neuroticism score 0.0 0.1 0.1 -0.2 0.3
Weight 2.0 9.7 16.9 -4.1 -1.6
Impedance of arm (right) 1.3 6.0 12.0 -0.3 3.5
Arm fat percentage (right) 2.1 8.1 13.8 -3.7 -1.6
Trunk fat-free mass 0.8 4.6 7.3 -2.7 -1.4
Hip circumference 2.5 10.8 18.5 -4.3 -1.8
Time employed in main current job 0.1 0.1 0.2 -0.2 0.4
Alcohol intake versus 10 years previously 1.5 2.2 4.3 -0.2 -2.1
Father’s age at death 1.5 2.0 4.0 -0.1 2.0
Worrier / anxious feelings 1.0 1.9 2.7 -1.1 -1.6
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 1.9 -0.8 -1.4
Falls in the last year 0.3 0.3 0.7 -0.2 -0.8
Hair/balding pattern: Pattern 3 0.3 0.5 0.6 -0.6 -0.8
Number of live births 0.0 0.0 0.0 0.2 -0.1
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 4.8 0.3 2.2
Pulse rate 3.3 5.6 6.4 2.5 2.2
Happiness 0.7 0.9 1.6 1.3 -0.4
Noisy workplace 0.2 0.2 0.5 -0.7 0.1
Qualifications: A levels/AS levels or equivalent 0.6 1.3 1.5 -1.2 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.2 -0.5 -0.4
Mouth/teeth dental problems: Dentures 0.0 0.0 0.1 -0.1 0.3
Asthma 3.0 5.9 8.9 1.7 3.0
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 2.2 -0.3 1.5
Medication: Cholesterol lowering 3.7 5.7 11.2 0.4 -3.4
Depression (self-reported) 1.5 1.8 2.5 1.6 1.1
Medication: Lansoprazole 0.7 0.8 1.2 0.6 1.1
Prospective memory result 2.5 3.0 4.7 -1.2 -2.2
Lung cancer (father) 0.4 0.5 1.0 1.0 0.1
Illnesses of mother 1.0 1.3 2.4 0.3 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.3 6.5 -0.2 2.5
Pulse wave Arterial Stiffness index 0.7 0.9 1.7 -0.1 1.3
Impedance of arm (left) 1.1 5.0 10.0 -0.2 3.2
Arm fat mass (right) 2.3 9.3 15.6 -4.0 -1.7
Trunk predicted mass 0.8 4.3 7.0 -2.6 -1.3
Standing height 0.7 6.6 9.6 -3.1 1.9
Length of working week for main job 0.8 0.9 1.7 1.3 -0.1
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.4 0.1
Breastfed as a baby 0.9 1.1 2.0 -1.4 0.5
Tense / ‘highly strung’ 0.8 1.3 1.9 1.4 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.5 3.1 1.4 -1.8
Hair/balding pattern: Pattern 4 1.1 2.7 4.5 -2.1 -1.0
Birth weight of first child 1.8 3.2 5.3 -1.1 2.3
Peak expiratory flow (PEF) 0.5 1.1 1.7 -1.3 -0.7
Pulse wave reflection index 1.2 1.5 1.9 -1.4 -1.0
Ever highly irritable/argumentative for 2 days 0.7 0.8 0.8 0.9 0.9
Loud music exposure frequency 0.9 1.0 1.8 -1.4 -0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.5 -0.3 -0.7
Mouth/teeth dental problems: Bleeding gums 7.5 9.8 19.2 -0.6 -4.4
Blood clot in the leg (DVT) 1.6 2.0 2.3 -1.3 1.5
Medication: Paracetamol 0.1 0.2 0.3 -0.6 0.4
Headache pain in last month 1.1 1.9 3.8 -0.1 2.0
Medication for cholesterol, blood pressure or diabetes 2.7 4.6 9.1 0.1 3.0
Glaucoma (self-reported) 0.6 0.6 1.2 -0.4 -1.1
Gout (self-reported) 0.9 1.3 2.5 1.6 -0.3
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.4 0.5 1.2
Medication: Amlodipine 0.6 0.8 1.5 -0.4 -1.2
Medication: Ventolin 100micrograms inhaler 1.0 1.2 2.2 0.5 1.5
Birth weight 0.6 1.3 2.5 -0.5 1.6
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.5 -0.6 -1.2
High blood pressure (siblings) 0.8 1.2 2.2 0.3 -1.5
Forced vital capacity (FVC), Best measure 1.3 4.7 9.1 0.5 3.0
Body fat percentage 2.1 8.3 13.1 -3.6 -1.9
Leg fat percentage (right) 2.8 10.3 11.4 -3.0 -3.4
Arm fat-free mass (right) 0.8 4.1 5.7 -2.4 -1.6
Exposure to tobacco smoke outside home 0.6 0.8 0.8 -0.9 -0.9
Comparative body size at age 10 1.4 4.0 6.7 -1.1 2.6
Number of full brothers 0.1 0.1 0.2 -0.5 0.1
Worry too long after embarrassment 1.1 1.8 3.1 0.7 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.2 -0.4
Wheeze or whistling in the chest in last year 0.3 0.5 0.7 0.5 -0.8
Number of children fathered 6.1 6.9 6.9 2.6 2.6
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.0 -0.2 0.1
Age at first live birth 0.7 1.3 1.3 1.1 -1.1
Pulse wave peak to peak time 0.3 0.4 0.8 0.1 -0.9
Health satisfaction 2.0 2.6 2.6 -1.6 -1.6
Shortness of breath walking on level ground 2.7 3.2 3.3 -1.8 -1.8
Qualifications: College or University degree 0.4 1.2 2.1 -1.5 0.5
Eye problems/disorders: None of the above 1.4 1.7 3.3 -0.1 1.8
Mouth/teeth dental problems: Loose teeth 1.7 2.0 2.8 -1.1 -1.7
Emphysema/chronic bronchitis 0.6 0.7 1.1 -1.1 0.5
Medication for pain relief, constipation, heartburn 0.4 0.6 1.1 1.0 -0.4
Neck or shoulder pain in last month 0.2 0.2 0.5 0.0 -0.7
Medication: Blood pressure 2.3 4.0 7.6 -0.5 -2.8
Angina (self-reported) 2.4 3.1 3.3 -1.7 -1.8
Migraine (self-reported) 0.4 0.5 0.5 0.7 0.7
Medication: Ibuprofen 0.2 0.2 0.4 -0.1 0.6
Medication: Allopurinol 0.2 0.2 0.3 0.5 -0.5
Medication: Omeprazole 0.4 0.5 1.0 1.0 0.0
Medication: Seretide 50 evohaler 1.2 1.4 1.9 0.9 1.4
Mean time to correctly identify matches 1.5 3.0 5.9 -2.4 -0.0
Heart disease (mother) 1.2 1.5 2.0 -1.0 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 2.0 -0.4 -1.4
Whole body fat mass 2.5 10.4 16.6 -4.1 -2.0
Leg fat mass (right) 2.8 10.7 12.7 -3.6 -2.9
Arm predicted mass (right) 0.9 4.5 6.2 -2.5 -1.7
Pulse rate, automated reading 2.5 8.2 12.8 3.6 1.9
Alcohol intake frequency. 0.5 1.1 2.1 0.4 -1.4
Comparative height size at age 10 0.6 3.3 3.5 -1.8 1.9
Number of full sisters 3.5 4.3 6.1 1.6 2.5
Suffer from ‘nerves’ 0.3 0.4 0.6 -0.4 0.8
Overall health rating 1.0 2.0 3.6 -0.7 -1.9
Chest pain or discomfort 0.5 0.8 1.2 -0.6 -1.1
Had major operations 0.1 0.1 0.2 0.2 -0.5
Age at last live birth 1.0 1.5 2.1 0.9 -1.4
Family relationship satisfaction 0.9 1.1 2.1 -0.0 -1.5
Leg pain on walking 1.2 1.5 1.9 1.0 -1.4
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 4.2 2.0 -0.7
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.7 0.2 0.8
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.3 0.0 -1.5
Medication: Aspirin 0.5 0.6 0.9 -1.0 -0.5
Supplements: Vitamin C 1.3 1.5 3.0 -1.7 -0.2
Knee pain experienced in last month 0.1 0.1 0.2 0.4 -0.1
Hypertension (Self-reported) 1.7 4.7 7.6 -1.3 -2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.3 0.4 0.6
Illnesses of father: Heart disease 0.6 0.8 1.4 -0.5 -1.2
Illnesses of siblings: Diabetes 0.1 0.1 0.1 -0.3 0.3
Smoking status: Previous 2.4 3.6 5.7 -1.2 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 3.3 -1.8 0.3
Whole body fat-free mass 1.0 5.5 10.1 -3.2 -0.9
Leg fat-free mass (right) 1.1 5.7 11.4 -3.4 0.3
Arm fat percentage (left) 1.9 7.7 13.0 -3.6 -1.5
Average weekly red wine intake 1.2 1.7 3.4 1.8 0.2
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 0.2 0.4
Mood swings 0.0 0.0 0.1 0.1 0.3
Loneliness, isolation 1.0 1.4 2.7 1.7 -0.3
Long-standing illness, disability or infirmity 1.0 1.5 2.9 0.2 -1.7
Ever had bowel cancer screening 0.6 0.7 1.3 -1.1 -0.3
Diabetes diagnosed by doctor 0.4 0.6 0.8 0.9 0.6
Ever had stillbirth, spontaneous miscarriage or termination 2.6 2.8 4.7 -1.0 -2.2
Friendships satisfaction 0.4 0.5 1.1 1.0 0.2
Qualifications: nursing, teaching 0.9 1.5 1.5 1.2 1.2
Commuting to job workplace: Walk 1.9 2.1 3.9 2.0 -0.5
Eye problems/disorders: Cataract 0.6 0.7 0.8 -0.9 -0.8
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 3.2 0.2 -1.8
Medication for cholesterol 0.7 1.0 1.6 0.7 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.1 3.7 -1.9 0.7
Back pain experienced in last month 0.2 0.3 0.4 -0.5 0.7
Mineral and other dietary supplements 0.5 0.6 0.9 -1.0 -0.6
Breast cancer (self-reported) 1.6 1.9 3.8 -0.3 -1.9
Asthma (self-reported) 3.5 6.9 10.8 1.7 3.3
Osteoporosis (self-reported) 0.0 0.0 0.1 -0.2 0.1
Osteoarthritis (self-reported) 1.8 2.3 3.2 1.2 -1.8
Medication: Aspirin 0.3 0.4 0.4 -0.6 -0.6
Medication: Gliclazide 2.2 2.5 2.9 -1.7 -1.4
Illnesses of father: None of the above (group 1) 0.9 1.2 2.2 1.5 0.4
Smoking status: Current 0.7 1.1 1.6 0.8 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 1.9 1.2 1.4
Whole body water mass 0.9 5.3 9.6 -3.1 -1.0
Leg predicted mass (right) 1.1 5.6 11.2 -3.3 0.3
Arm fat mass (left) 2.2 8.9 14.9 -3.9 -1.7
Number of self-reported non-cancer illnesses 0.1 0.2 0.4 0.0 -0.7
Average weekly champagne plus white wine intake 2.0 2.7 3.0 -1.6 -1.7
Miserableness 0.0 0.0 0.1 -0.2 0.0
Guilty feelings 0.0 0.0 0.0 -0.2 -0.0
Wears glasses or contact lenses 0.6 0.7 0.8 -0.7 0.9
Ever taken oral contraceptive pill 2.4 2.7 3.4 -1.4 -1.9
Hearing aid user 0.5 0.6 1.0 1.0 0.5
Mother’s age at death 1.2 1.5 2.9 -1.7 0.1
Financial situation satisfaction 0.2 0.2 0.4 -0.6 0.1
Tinnitus: Yes, now most or all of the time 1.9 2.2 4.2 0.4 2.1
Commuting to job workplace: Public transport 1.2 1.4 1.5 -1.2 -1.2
Eye problems/disorders: Glaucoma 0.3 0.3 0.6 -0.1 -0.8
Medication: Blood pressure 2.2 4.2 4.7 -1.9 -2.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.7 0.8 0.5
Supplements: Fish oil (including cod liver oil) 1.4 1.8 3.5 0.4 1.9
High cholesterol (Self-reported) 2.5 4.4 7.5 -1.2 -2.7
Medication: Bendroflumethiazide 0.5 0.8 0.8 -0.8 -0.9
Medication: Paracetamol 0.2 0.3 0.5 -0.7 0.2
Medication: Lisinopril 0.0 0.0 0.1 -0.1 -0.2
Medication: Atorvastatin 0.9 1.1 1.5 -1.2 -0.9
Illnesses of father: High blood pressure 0.1 0.1 0.2 0.0 -0.5
Alcohol drinker status: Never 0.3 0.3 0.7 -0.8 -0.1
Ever smoked 2.0 3.6 5.6 -1.2 -2.4
Basal metabolic rate 1.1 6.2 11.2 -3.4 -1.1
Leg fat percentage (left) 2.6 9.5 9.9 -3.0 -3.1
Arm fat-free mass (left) 0.9 4.6 6.6 -2.6 -1.6
Number of operations (self-reported) 0.5 0.7 1.5 -1.2 0.1
Average weekly beer plus cider intake 0.5 0.7 0.7 0.8 0.8
Irritability 0.2 0.4 0.8 -0.9 -0.1
Risk taking 2.5 3.6 6.9 2.6 0.6
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.4 0.8 1.2
Fractured/broken bones in last 5 years 0.7 0.9 1.6 1.3 -0.5
Age started oral contraceptive pill 1.1 1.4 1.7 -1.0 -1.3
Diastolic blood pressure, automated reading 0.5 1.5 2.1 1.4 1.0
Ever depressed for a whole week 1.8 2.2 4.5 -0.0 -2.1
Unable to work because of sickness or disability 1.9 2.4 4.3 2.1 -0.7
Commuting to job workplace: Cycle 0.3 0.3 0.6 0.2 -0.8
Myopia 0.7 1.0 1.6 0.6 -1.3
Vascular/heart problems diagnosed by doctor 1.9 5.3 9.3 1.1 3.0
Cholesterol lowering medication 2.7 4.0 5.9 -1.4 -2.4
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.9 0.9 0.4
Pain experienced in last month 0.1 0.1 0.2 0.1 -0.4
Supplements: Calcium 0.1 0.1 0.1 -0.1 -0.4
Basal cell carcinoma (self-reported) 0.5 0.6 0.9 -0.5 -0.9
Heart attack/myocardial infarction (self-reported) 2.4 3.1 6.1 -0.2 -2.5
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 2.4 -1.4 1.6
Heart disease (siblings) 5.7 7.0 12.6 -1.2 -3.5
Alcohol drinker status: Previous 2.0 2.2 4.3 2.1 0.5
Pack years of smoking 0.7 1.0 1.3 0.9 -1.2
Impedance of whole body 0.5 2.6 4.8 0.7 2.2
Leg fat mass (left) 2.5 9.9 12.3 -3.5 -2.7
Arm predicted mass (left) 1.2 6.1 7.8 -2.8 -2.1