Hub : Genes

FMN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.2240	0.0710	3.2e-03	0.016	NA	0.041	NA	0.027	4.7e-02	NA	3.7e-03	NA	1.5e-02
2	GTEx	Esophagus Mucosa	0.1410	0.0510	3.7e-03	0.173	NA	0.170	NA	0.172	1.1e-11	NA	1.9e-11	NA	1.3e-11
3	GTEx	Skin Sun Exposed Lower leg	0.1560	0.0520	1.6e-03	0.066	NA	0.068	NA	0.066	3.6e-06	NA	2.7e-06	NA	3.7e-06
4	GTEx	Testis	0.2840	0.0850	7.0e-04	0.021	NA	0.030	NA	0.034	3.9e-02	NA	1.7e-02	NA	1.2e-02
5	GTEx	Thyroid	0.3860	0.0530	4.9e-14	0.199	NA	0.226	NA	0.236	3.6e-15	NA	2.9e-17	NA	4.9e-18
6	GTEx	Whole Blood	0.0890	0.0340	7.2e-03	0.037	NA	0.042	NA	0.039	2.4e-04	NA	9.2e-05	NA	1.5e-04
7	METSIM	Adipose	0.1238	0.0275	1.0e-09	0.122	0.076	0.113	0.116	0.117	8.1e-18	1.7e-11	1.8e-16	5.9e-17	4.9e-17
8	NTR	Blood	0.3325	0.0280	0.0e+00	0.419	0.369	0.426	0.423	0.425	9.3e-149	1.2e-126	4.0e-152	1.2e-150	1.5e-151
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0455	0.0204	7.2e-03	0.045	0.019	0.045	NA	0.040	7.1e-06	3.0e-03	8.4e-06	NA	2.5e-05
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0430	0.0202	8.7e-03	0.013	0.021	0.000	NA	0.004	1.2e-02	1.6e-03	3.6e-01	NA	1.1e-01
11	TCGA	Lung Adenocarcinoma	0.0593	0.0218	8.4e-04	0.014	0.031	0.012	NA	0.018	8.5e-03	1.3e-04	1.3e-02	NA	3.2e-03
12	TCGA	Prostate Adenocarcinoma	0.1416	0.0342	2.2e-10	0.107	0.115	0.072	NA	0.102	2.8e-11	5.4e-12	5.4e-08	NA	8.2e-11
13	TCGA	Thyroid Carcinoma	0.1770	0.0410	8.7e-10	0.070	0.121	0.104	NA	0.106	2.2e-07	8.5e-12	2.6e-10	NA	1.8e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.4	0.7	1.5	-1.2	-1.2	-0.3	0.8	-1.1	-0.3	0.6	0.7	-1.0	-0.6	0.2	-0.7	-1.1
Bipolar Disorder or Schizophrenia	0.4	1.1	3.2	0.7	-1.8	-0.6	1.6	-0.4	-1.2	0.2	0.3	-1.6	-0.3	1.3	-0.7	-0.8
Depressed Affect (Nagel 2018)	0.6	1.3	4.2	-0.3	0.3	1.0	1.5	0.5	-0.5	1.5	2.0	0.5	1.6	-1.1	1.5	0.9
Depression (Nagel 2018)	0.5	0.8	1.6	-1.3	0.8	0.6	-1.2	0.1	0.7	1.0	0.9	0.9	1.2	-0.1	1.2	0.8
Intelligence (Savage-Jansen 2018)	1.8	5.5	11.8	-1.3	3.4	2.6	-0.4	2.8	2.7	1.2	0.6	3.4	2.5	1.5	3.1	2.2
Neuroticism (Nagel 2018)	0.7	1.6	5.8	-0.0	0.6	1.5	0.9	0.1	0.9	2.1	2.4	0.8	0.6	-2.0	1.2	0.2
Schizophrenia (2018)	0.5	1.0	3.2	1.8	-1.3	-0.6	1.4	0.4	-1.3	-0.2	-0.1	-1.3	0.2	1.6	-0.4	-0.1
Schizophrenia vs Biploar Disorder	0.9	1.2	2.5	-0.7	0.4	-0.8	-1.0	1.2	0.1	-1.2	-1.4	0.3	1.6	1.5	0.9	1.4
Worry (Nagel 2018)	0.4	0.9	4.1	-0.6	0.1	0.6	0.0	-0.9	1.4	1.0	1.2	0.2	-1.0	-2.0	-0.5	-0.7
Alzheimer’s Disease (in mother)	1.3	1.5	3.4	1.8	-0.8	-1.2	1.5	-1.3	-0.7	-1.6	-1.6	-1.1	-1.1	0.1	-1.3	-1.1
Alzheimer’s Disease (in father)	0.8	0.9	3.3	0.6	0.5	1.8	-0.4	0.5	1.8	1.2	1.2	0.6	-0.3	-0.3	0.5	0.3
Alzheimer’s Disease (including proxy)	0.8	1.2	4.1	1.6	-1.1	-0.2	0.3	-1.4	0.2	-0.2	-0.2	-1.1	-2.0	-0.9	-1.4	-1.1
Crohns Disease (2017)	0.5	1.1	3.0	0.3	1.0	0.7	0.7	1.6	1.2	0.3	0.1	0.9	1.6	1.7	0.7	1.1
Irritable Bowel Disease (IBD)	0.2	0.4	1.7	-0.2	0.3	0.4	1.2	0.5	-0.4	0.4	0.2	-0.0	0.8	1.3	0.1	0.4
Ulcerative Colitis (UC)	0.2	0.4	2.7	-0.1	-0.0	0.1	1.6	-0.1	-1.5	0.1	0.2	-0.3	0.1	0.8	-0.1	0.2
Major Depression (MDD)	0.2	0.2	0.6	-0.2	0.6	-0.7	-0.5	0.2	-0.3	0.1	0.1	0.8	0.8	0.5	0.7	0.2
Reaction Time	0.2	0.3	1.0	-0.6	-0.3	-0.3	0.1	0.3	1.0	-0.9	-0.7	-0.2	0.6	0.4	0.1	0.3
Verbal and Numeric Reasoning (VNR)	2.8	6.7	14.3	-1.8	3.8	2.7	0.4	3.4	1.6	1.5	1.0	3.7	3.2	1.7	3.5	2.4
Breast Cancer	0.4	1.0	3.1	0.9	0.5	-0.7	-0.1	0.7	-0.4	-1.6	-1.4	0.4	1.3	1.8	1.0	0.8
Ovarian Cancer	0.5	0.7	2.2	0.3	0.6	1.5	0.4	0.3	1.4	1.0	1.1	0.7	0.4	-0.2	1.0	0.7
Prostate Cancer	5.3	7.4	14.4	-0.6	-3.8	-2.6	-0.6	-3.7	-3.5	-1.3	-1.2	-3.8	-2.5	-1.8	-3.6	-3.0
Age at First Birth	1.6	2.3	9.8	-2.3	2.0	1.2	-0.2	1.0	3.1	1.1	0.8	2.0	0.5	0.7	0.9	1.2
Bipolar Disorder (2011)	0.9	0.9	4.5	0.2	-0.0	1.0	2.1	-0.4	0.8	0.8	0.7	-0.1	-1.4	0.6	-1.2	-0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	1.3	-0.2	-0.1	-1.1	0.0	-0.3	-1.2	-0.9	-0.2	-0.2	-0.5	0.1	-0.0
Coronary Artery Disease (CAD)	0.6	0.7	3.1	-1.8	0.3	0.3	0.8	-0.1	1.4	0.6	0.7	0.2	0.5	0.8	0.4	1.2
Crohns Disease (2012)	0.2	0.3	1.6	0.0	0.4	0.6	-0.3	0.6	1.3	0.7	0.3	0.1	-0.2	0.7	-0.6	0.4
Mean Putamen Volume	0.2	0.3	0.8	0.4	0.4	0.4	-0.9	-0.1	-0.3	0.7	0.7	0.5	-0.3	-0.9	0.1	-0.1
Fasting Glucose	0.3	0.4	1.7	0.2	-0.1	0.2	-1.3	0.3	-1.3	-0.6	-0.1	0.1	0.4	-1.0	0.2	-0.2
HbA1C	0.5	0.5	1.5	0.8	-0.6	-0.5	0.0	-1.2	-0.5	-0.5	-0.4	-0.7	-0.8	-0.7	-0.7	-1.1
HDL Cholesterol	0.2	0.3	1.0	-0.9	0.4	0.7	0.4	0.3	-0.4	0.8	1.0	0.4	-0.2	0.1	-0.1	0.0
LDL Cholesterol	0.1	0.1	0.4	-0.0	0.4	-0.4	0.1	0.2	0.5	-0.4	-0.6	0.5	-0.4	-0.2	-0.2	-0.0
Lupus	0.7	1.1	2.4	0.5	1.0	1.5	-1.5	0.7	-0.8	0.9	1.0	1.1	1.1	-0.9	1.3	0.8
Neuroticism (2016)	1.5	2.2	4.1	-0.2	1.3	1.5	0.8	1.3	1.7	1.9	1.8	1.5	1.9	0.2	2.0	1.4
Primary Biliary Cirrhosis	0.2	0.3	1.0	0.5	0.2	-0.3	0.4	1.0	-0.3	-0.7	-0.3	0.1	0.4	0.8	-0.3	-0.6
Rheumatoid Arthritis	0.6	0.8	3.0	-0.8	1.1	1.7	0.3	0.7	0.2	0.8	0.6	1.1	-1.0	0.7	-0.3	1.0
Schizophrenia (2014)	0.6	1.4	6.4	0.7	-1.0	-1.1	1.3	0.7	-1.2	-1.1	-1.2	-1.0	1.3	2.5	0.0	0.2
Triglycerides	0.4	0.6	1.9	0.1	-1.3	-0.6	0.1	-0.6	-0.9	-0.8	-0.7	-1.4	-0.4	-0.7	-0.7	-0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.2	-0.4	-0.6	-1.1	0.5	-0.6	-0.0	-0.4	-0.3	-0.6	0.1	-0.1	-0.2	-0.1
Ulcerative Colitis	0.2	0.2	1.0	0.4	0.2	-0.1	-0.0	0.2	-0.9	-0.3	-0.3	-0.0	0.9	1.0	0.3	0.4
Blood Eosinophil Count	0.0	0.3	0.8	-0.3	-0.6	-0.5	0.9	-0.6	0.6	0.5	0.6	-0.8	0.4	-0.6	-0.4	-0.1
Blood Platelet Count	0.2	2.6	8.0	-1.4	-1.8	-2.3	0.3	-1.6	-0.2	-2.8	-2.8	-1.7	-0.4	-0.5	-1.3	-0.3
Blood Red Count	1.1	10.4	38.4	1.4	3.3	6.2	0.2	3.2	2.1	4.9	5.0	3.3	1.6	-1.3	1.6	1.6
Blood White Count	0.2	1.7	11.2	0.5	-1.1	-0.4	-0.8	-1.5	-0.6	-0.1	0.3	-1.0	-1.2	-3.3	-1.0	-1.6
Heel T-Score	0.3	2.2	8.2	-2.9	-1.4	-1.8	1.6	-1.3	-0.3	-1.8	-1.5	-1.4	-0.8	-0.9	-1.0	-1.2
BMI	0.2	1.2	5.3	-0.1	-0.7	-2.3	0.4	-0.2	-0.1	-1.6	-1.7	-0.6	0.8	1.6	0.4	0.6
Height	0.3	4.8	10.8	-0.6	2.2	1.6	1.9	2.6	3.3	1.1	1.2	2.2	2.4	3.1	2.0	2.7
Waist Hip Ratio (WHR)	0.2	0.9	3.3	-0.1	0.8	1.0	-0.2	1.1	1.2	1.2	1.2	0.8	0.7	-1.8	-0.0	-0.2
Systolic Blood Pressure	0.3	1.4	11.5	-0.6	-0.4	-0.6	3.4	-0.6	1.1	-0.4	-0.0	-0.5	-0.6	1.0	-1.5	-0.4
Smoking Status	0.3	0.8	3.7	-0.7	-0.1	0.1	-1.0	-0.2	-1.6	-0.2	-0.5	-0.0	-1.4	-1.9	-0.3	-0.2
Allergy or Eczema	0.7	1.7	4.1	-0.6	1.5	1.6	-0.2	1.7	1.5	0.2	0.2	1.5	2.0	0.2	1.4	1.9
Cardiovascular Disease	0.1	0.5	2.0	0.6	-0.4	-1.0	0.8	-0.8	0.5	-0.2	-0.1	-0.2	-1.4	0.5	-0.7	0.4
Hypothyroidism (self reported)	0.2	0.6	2.2	1.2	0.2	0.8	1.5	0.9	0.4	-0.4	-0.3	0.5	0.5	0.9	0.7	0.2
Respiratory disease	0.3	0.7	1.5	0.9	0.7	0.5	-0.4	1.0	0.5	-1.2	-1.2	0.8	0.6	1.2	0.5	1.0
Type 2 Diabetes (T2D) (2018)	0.7	1.3	5.6	-1.5	-0.2	0.6	-1.6	-1.0	-0.0	1.1	0.9	-0.2	-1.4	-2.4	-0.4	-0.6
Lung FEV1/FVC ratio	0.4	1.8	4.8	1.3	1.2	1.5	-1.8	0.7	0.9	2.2	2.0	1.4	0.6	-0.2	1.3	0.5
Lung FVC	0.9	4.8	12.5	-2.8	-2.3	-2.9	0.6	-1.8	-2.0	-3.5	-3.3	-2.4	-1.4	-0.2	-1.4	-0.3
Neuroticism	0.2	0.4	1.3	-0.4	-0.0	0.3	1.0	-0.1	0.3	1.0	1.1	-0.0	0.2	-1.2	-0.3	-0.6
Chronotype (morning person)	0.5	1.2	5.8	-1.5	-0.4	-0.4	2.4	0.7	0.2	-0.7	-0.6	-0.2	1.0	1.8	0.8	0.9
Hair Pigment	0.1	1.8	4.6	-1.5	0.2	-1.2	-0.3	0.8	1.7	-1.2	-1.2	0.2	1.7	2.1	1.8	1.7
Tanning	0.1	0.7	1.8	-0.4	0.7	1.1	-0.5	1.3	0.6	1.4	1.0	0.6	1.2	0.2	-0.1	-0.2
Hand grip strength (left)	0.4	1.1	2.7	-0.6	-1.0	-1.0	-0.2	-1.1	-1.0	-1.1	-1.3	-1.1	-1.0	1.6	-0.7	-0.8
Number of treatments/medications taken	0.1	0.2	0.9	0.4	-0.2	0.1	0.2	-0.6	-0.3	0.6	0.7	-0.0	-0.9	-0.0	-0.5	-0.2
Average weekly spirits intake	0.6	0.8	2.7	0.5	1.0	0.4	-0.3	1.7	0.2	-0.5	-0.5	1.1	1.2	0.7	1.4	0.3
Sensitivity / hurt feelings	0.6	1.0	4.4	0.1	0.4	0.8	1.5	0.4	1.1	2.0	2.1	0.6	-0.2	0.1	0.4	0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.3	-0.1	0.8	0.5	-0.3	0.7	0.4	1.1	1.1	1.0	0.7	-0.0	0.7	0.8
Hearing difficulty/problems: Yes	1.3	2.0	4.2	1.9	-1.7	-1.4	-0.8	-2.0	-1.3	0.3	0.5	-1.6	-1.6	-1.1	-1.6	-1.1
Relative age of first facial hair	0.5	1.0	1.9	-1.4	-1.2	-0.8	-0.5	-1.2	-1.3	-0.8	-0.9	-1.2	-1.1	-0.7	-0.7	-0.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	5.3	1.3	-0.4	0.1	-2.3	-0.4	-0.5	-0.7	-1.4	-0.4	-1.2	-0.4	-1.1	-0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.9	0.2	-1.0	-0.7	0.2	-0.6	-0.0	0.4	0.3	-1.0	0.2	-0.4	-0.3	-0.8
Ever had hysterectomy (womb removed)	0.5	0.6	3.5	0.8	-0.9	-0.9	1.9	0.2	0.0	-0.0	0.2	-0.8	-0.4	0.3	0.5	-0.6
Systolic blood pressure, automated reading	0.3	1.0	5.7	1.0	-1.0	-1.1	2.4	-0.8	-0.1	-0.4	0.1	-0.9	-0.6	0.5	-1.0	-0.6
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	4.5	-1.8	-1.8	-1.3	-0.1	-1.9	-0.3	-0.9	-1.0	-1.6	-2.0	-1.0	-2.1	-1.8
Angina	0.8	1.1	3.1	0.9	-1.0	-0.2	-0.4	-1.4	-1.1	0.3	0.2	-0.9	-1.2	-1.7	-1.8	-1.0
Medication for hormone replacement therapy	0.7	0.8	2.3	-0.5	-1.4	-0.8	-0.7	-1.5	-1.1	0.4	-0.0	-1.3	-0.6	0.0	-0.7	-0.7
Vitamin and mineral supplements	1.2	1.6	2.9	-0.9	1.7	0.9	1.2	1.2	1.2	1.6	1.6	1.7	0.6	0.5	1.3	1.4
Supplements: Zinc	0.2	0.2	0.7	0.8	-0.3	-0.4	-0.7	0.3	0.4	-0.1	0.2	-0.1	0.5	-0.2	0.8	0.6
Medication: Co-codamol	1.5	1.8	6.9	0.5	-1.2	-2.2	-0.7	-0.5	-2.6	-1.4	-1.5	-1.1	0.3	-0.4	-0.6	-1.6
Medication: Metformin	0.7	1.0	3.0	-1.0	0.7	1.3	-0.8	-0.1	1.0	1.4	1.3	0.8	-0.7	-1.7	0.4	0.3
Diabetes (father)	0.6	0.8	1.7	1.0	-0.5	-0.6	-1.1	-0.2	-1.2	-1.0	-1.1	-0.5	0.1	-0.8	-0.8	-1.3
Diabetes (mother)	0.5	0.7	2.4	0.4	0.6	0.7	-0.4	0.8	0.9	1.2	1.1	0.7	0.1	0.2	0.6	1.6
Severe depression (siblings)	0.4	0.4	2.8	1.7	-0.3	-0.2	-0.5	0.1	0.2	-0.6	-0.5	-0.3	0.1	0.2	1.2	0.1
Pack years adult smoking proportion	0.4	0.7	2.2	-1.2	0.3	0.9	1.3	0.5	0.5	1.3	1.5	0.3	-0.0	0.1	-0.2	-0.3
Impedance of leg (right)	0.2	0.9	6.2	-0.8	-0.6	-0.0	-1.3	-0.4	0.0	-0.2	-0.3	-0.5	-0.3	-2.5	-0.7	-1.4
Leg fat-free mass (left)	0.6	3.0	14.1	-1.0	1.5	0.4	0.5	1.6	2.0	0.2	0.1	1.6	1.9	3.8	1.4	2.6
Trunk fat percentage	0.1	0.4	1.1	-0.3	-0.7	-0.8	0.9	-0.3	0.6	0.5	0.8	-0.4	-0.0	-0.8	-1.1	-0.6
Hand grip strength (right)	0.2	0.5	4.1	-0.5	-0.4	-0.5	-0.1	-0.3	-0.1	-0.6	-0.8	-0.4	-0.4	2.0	0.1	-0.2
Townsend deprivation index at recruitment	0.7	0.9	6.2	0.1	-0.6	-0.6	1.3	-1.0	-0.8	0.0	0.1	-0.7	-1.0	0.3	-2.5	-0.6
Current tobacco smoking	0.4	0.7	5.8	0.7	0.1	0.1	-2.4	-0.3	-0.1	-0.1	-0.6	0.2	-1.2	0.1	-0.6	-0.2
Average weekly fortified wine intake	2.7	3.1	6.2	0.6	2.2	1.9	0.5	2.5	1.8	0.9	0.6	2.3	2.2	1.6	2.4	1.7
Maternal smoking around birth	0.6	0.8	2.3	-0.1	-1.1	-1.0	-0.6	-0.7	-1.0	-0.4	-0.7	-1.2	-0.7	1.5	-1.4	-0.2
Fed-up feelings	0.8	1.4	5.9	-0.1	0.7	1.3	1.2	0.7	0.3	2.1	2.4	0.9	1.5	-0.3	0.8	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.7	-1.3	-0.3	-0.7	0.1	-0.4	0.6	0.8	0.7	-0.2	0.3	1.1	0.4	0.8
Relative age voice broke	1.0	1.6	4.2	-1.4	-1.4	-0.9	-0.2	-1.9	-0.7	-0.2	-0.3	-1.4	-2.1	-0.6	-2.0	-1.1
Taking other prescription medications	0.5	0.8	2.7	1.3	-0.1	0.4	-0.0	-0.6	-0.5	0.9	0.9	0.1	-1.6	-1.2	-1.0	-0.9
Age when periods started (menarche)	0.7	1.7	3.8	-0.2	-1.5	0.4	1.7	-1.9	0.3	0.8	1.1	-1.5	-1.3	-1.9	-1.1	-1.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.2	0.8	-1.0	-0.5	-0.4	-0.4	-0.1	0.3	0.4	-1.1	-0.2	-0.3	-0.4	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.6	-1.9	-0.0	-1.0	-0.7	0.5	1.1	-1.6	-1.5	-0.2	1.1	1.6	0.2	0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	-0.0	-1.1	-0.9	-0.6	-0.5	0.1	-0.8	-0.8	-1.0	-0.3	0.3	-0.5	-0.1
Qualifications: CSEs or equivalent	1.3	1.8	5.2	0.4	-0.5	-1.4	0.1	1.2	-0.8	-2.3	-2.3	-0.4	1.5	2.2	-0.1	0.9
Serious illness, injury or assault to yourself	0.5	0.7	2.7	1.6	-0.5	-0.4	-0.1	-0.8	-0.7	0.5	0.5	-0.5	-1.2	-1.0	-0.7	-0.6
High blood pressure	0.4	1.0	3.2	0.6	-1.1	-1.8	1.1	-1.2	0.4	-0.6	-0.4	-0.9	-1.1	0.8	-1.4	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.7	-0.4	0.7	1.0	-0.3	1.0	0.6	-0.1	0.1	0.7	1.6	-0.6	0.9	0.8
Multivitamins +/- minerals	0.2	0.3	1.1	0.2	-0.3	-0.3	-0.8	-0.0	-0.5	-0.9	-1.0	-0.3	0.4	0.7	-0.3	-0.1
Stomach or abdominal pain in last month	1.1	1.3	4.6	0.3	-1.2	-0.1	0.2	-1.6	-0.8	0.5	0.7	-1.1	-1.3	-2.1	-1.4	-1.6
Supplements: Glucosamine	0.7	0.9	2.4	0.1	1.2	0.5	0.7	0.9	0.2	-0.4	-0.4	1.2	1.1	0.8	1.5	1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.4	-1.2	0.5	0.5	1.0	0.3	-0.6	0.7	0.7	0.5	-0.1	-0.1	0.0	1.1
Medication: Atenolol	1.0	1.3	3.8	-1.9	-1.4	-1.2	0.6	-1.3	-0.9	0.3	0.3	-1.4	-0.7	-0.9	-0.7	-1.6
Medication: Levothyroxine sodium	0.2	0.3	1.4	0.3	-1.2	-0.0	0.3	-0.4	-0.3	0.2	0.1	-1.0	-0.5	0.2	-0.6	0.1
Sitting height	1.0	7.3	18.1	-3.5	2.9	0.8	-0.4	3.4	3.0	-0.9	-1.2	2.7	4.3	3.0	3.0	2.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.9	-0.2	-0.3	0.1	0.3	-0.4	-0.9	-0.3	-0.1	-0.1	-0.9	-0.1	-0.5	-0.2
High blood pressure (mother)	0.9	1.2	4.1	0.2	-0.9	-1.3	0.3	-0.5	-0.5	-1.9	-2.0	-1.0	-1.2	1.1	-1.2	-0.4
Body mass index (BMI)	0.2	0.9	4.0	0.5	-0.4	-1.7	0.7	0.1	-0.3	-1.1	-0.9	-0.4	0.7	2.0	0.1	1.2
Impedance of leg (left)	0.4	1.8	11.6	-0.5	-1.0	-0.1	-1.2	-0.9	-0.4	-0.2	-0.2	-1.1	-1.0	-3.4	-1.2	-2.2
Leg predicted mass (left)	0.5	2.8	13.7	-1.0	1.5	0.4	0.5	1.5	1.9	0.2	0.1	1.5	1.8	3.7	1.2	2.5
Trunk fat mass	0.1	0.3	1.1	-0.4	-0.0	-0.7	0.7	0.3	1.0	0.3	0.5	0.1	0.6	0.5	-0.3	0.3
Waist circumference	0.1	0.5	2.2	0.3	0.2	-0.5	1.5	0.3	1.1	0.3	0.4	0.3	1.0	0.6	0.0	0.8
Number of incorrect matches in round	0.2	0.3	1.1	1.0	0.2	-0.4	1.1	0.1	-0.6	0.4	0.4	0.4	-0.2	0.5	0.9	-0.1
Past tobacco smoking	1.2	2.2	5.8	-0.4	-1.7	-1.7	-1.3	-2.0	0.4	-1.3	-1.2	-1.6	-0.8	-0.7	-2.0	-2.4
Alcohol usually taken with meals	0.9	1.4	5.9	0.6	0.2	-1.6	0.7	-0.0	-0.2	-2.4	-2.4	-0.1	0.1	1.8	0.4	0.3
Nervous feelings	1.2	2.2	6.7	-2.0	-1.1	0.4	0.2	-1.5	-0.9	0.5	1.0	-1.0	-2.1	-2.6	-1.9	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.9	-0.2	0.5	0.9	0.5	0.4	1.7	1.5	1.5	0.7	0.5	0.1	0.1	-0.2
Hearing difficulty/problems with background noise	0.7	1.1	2.8	1.0	-1.7	-1.5	-0.7	-0.9	0.4	0.5	0.6	-1.6	-0.3	-0.5	-1.4	-1.1
Hair/balding pattern: Pattern 2	0.5	0.7	4.2	-0.1	0.5	0.4	-2.1	-0.3	0.3	0.4	0.2	0.6	0.2	-1.6	-0.3	-0.8
Had menopause	0.5	0.6	4.4	0.9	-0.5	0.0	2.1	0.3	0.4	0.6	0.7	-0.4	0.8	0.3	-0.1	-0.9
Had other major operations	1.3	1.6	4.8	0.0	1.7	1.1	-0.2	1.8	0.5	0.8	0.4	1.7	1.1	1.2	1.5	2.2
Forced vital capacity (FVC)	0.4	1.7	8.1	-2.8	-0.1	-0.6	1.1	-0.0	0.6	-2.0	-2.1	-0.3	-0.3	1.3	-0.5	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	4.2	-2.1	0.5	-0.4	-0.1	0.8	1.1	-0.8	-0.8	0.3	1.3	1.5	0.5	0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	0.7	-0.3	-0.6	-0.6	-0.6	0.0	1.3	1.2	-0.2	-1.1	0.6	-1.2	0.0
Qualifications: None of the above	0.8	1.7	5.5	-0.2	-0.2	1.4	2.3	-0.2	0.9	1.8	2.1	-0.3	-1.2	-1.6	-1.2	-0.7
Financial difficulties in last 2 years	0.2	0.2	0.7	0.6	-0.6	-0.7	-0.7	-0.2	-0.5	0.4	0.3	-0.3	0.0	-0.0	-0.8	-0.1
Mouth/teeth dental problems	0.6	0.9	4.9	-0.0	-0.5	-1.3	-2.2	-0.5	-1.1	-1.1	-1.2	-0.6	-0.1	0.0	-0.4	0.4
Heart attack	0.6	0.8	2.8	1.0	-0.2	0.2	1.4	-0.6	-0.1	1.5	1.7	-0.2	-0.2	-1.4	0.0	-0.3
Allergy	0.1	0.2	0.6	-0.6	-0.4	-0.8	0.6	-0.3	0.1	-0.2	-0.2	-0.4	-0.6	0.7	-0.2	-0.3
Pain all over the body in last month	0.2	0.2	1.7	-0.1	-0.2	-0.3	0.5	-0.6	0.2	0.0	-0.2	-0.2	0.1	0.2	-0.1	1.3
Diabetes (self-reported)	0.5	0.7	1.8	0.8	0.7	1.3	-0.3	-0.0	0.8	1.1	1.1	0.7	-1.0	-1.3	0.2	0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.2	1.1	1.0	1.4	0.4	1.8	1.7	0.6	0.8	1.0	1.5	-0.0	1.2	0.5
Medication: Ramipril	1.1	1.4	3.8	-0.2	-1.1	0.3	0.9	-1.5	-1.2	1.1	1.3	-1.2	-1.6	-1.0	-1.9	-0.7
Medication: Simvastatin	1.0	1.5	4.7	0.7	1.5	2.2	0.3	0.6	1.1	1.5	1.5	1.4	0.0	-1.8	0.6	-0.1
Fluid intelligence score	1.5	3.1	8.7	-1.6	3.0	2.6	-0.9	1.3	1.1	0.9	0.7	2.8	1.1	0.0	2.6	1.2
Illnesses of siblings	0.9	1.2	7.5	0.9	1.0	0.8	-2.7	0.7	2.0	0.2	-0.2	0.9	0.5	-0.4	-0.1	0.3
Neuroticism score	0.3	0.5	2.4	-0.9	0.2	0.3	0.9	0.3	0.7	1.4	1.6	0.3	0.2	-0.5	-0.3	-0.1
Weight	0.3	1.4	7.1	-0.5	0.8	-0.5	0.6	1.0	1.2	-0.2	-0.2	0.8	1.5	2.7	0.8	1.9
Impedance of arm (right)	0.7	3.1	13.7	-1.4	0.5	1.7	-1.1	0.1	1.8	2.6	2.6	0.7	-0.3	-3.7	-1.0	-1.4
Arm fat percentage (right)	0.1	0.2	1.5	0.1	-0.2	-1.2	0.4	0.2	0.4	-0.1	0.3	-0.0	0.8	0.1	-0.1	0.5
Trunk fat-free mass	0.4	2.3	13.3	-0.0	1.4	0.4	-0.1	1.2	1.2	-0.0	-0.2	1.2	1.4	3.6	1.4	2.3
Hip circumference	0.2	0.7	2.8	-0.6	-0.3	-1.2	1.4	-0.4	0.6	-0.6	-0.6	-0.3	0.8	1.7	-0.1	0.6
Time employed in main current job	0.5	0.6	1.5	0.6	-0.1	-1.2	-1.1	-0.1	0.8	-1.2	-1.1	-0.1	0.7	-0.2	0.8	0.1
Alcohol intake versus 10 years previously	1.2	1.7	4.4	0.4	-0.7	-0.4	-1.1	-2.1	-1.2	0.8	0.6	-0.7	-2.0	-1.4	-1.9	-1.9
Father’s age at death	0.5	0.6	2.1	-0.2	1.1	0.4	-0.3	1.1	1.4	0.2	0.1	1.3	0.7	0.8	0.5	0.4
Worrier / anxious feelings	0.4	0.8	2.7	-1.6	-0.3	-0.4	0.4	-1.0	1.7	0.8	0.9	-0.3	0.0	-0.8	-0.6	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	3.1	0.4	0.6	0.5	0.1	0.4	0.6	1.7	1.8	0.8	-0.1	0.7	0.1	1.0
Falls in the last year	0.3	0.4	1.0	-0.8	-0.7	0.0	0.0	-0.2	1.0	0.9	0.8	-0.5	-0.7	0.2	-0.9	-0.0
Hair/balding pattern: Pattern 3	0.9	1.4	3.4	0.2	1.3	1.5	1.5	1.8	1.3	0.4	0.5	1.3	1.1	1.1	1.4	0.5
Number of live births	0.5	0.7	4.5	-0.2	-0.1	-0.2	1.2	0.8	0.8	0.6	0.5	-0.1	2.1	0.7	0.7	-0.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.4	-1.9	0.5	-0.1	0.6	0.4	1.1	-1.4	-1.5	0.4	0.0	1.4	0.0	1.1
Pulse rate	0.5	0.8	2.2	1.4	0.6	0.1	1.5	0.9	0.8	-0.3	-0.4	0.6	0.9	0.8	1.1	0.9
Happiness	0.8	0.9	3.8	-1.0	0.2	1.2	0.9	-0.5	0.4	2.0	1.9	0.3	-0.9	-0.4	0.1	0.1
Noisy workplace	0.1	0.2	0.6	0.3	-0.8	-0.7	0.3	-0.3	0.1	-0.6	-0.3	-0.7	-0.1	-0.2	-0.1	0.0
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.2	0.1	1.5	0.6	-1.1	1.0	0.8	-0.4	-0.7	1.4	0.7	1.0	1.2	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	7.0	-0.6	-0.4	0.1	-2.6	0.2	-1.1	-0.1	-0.3	-0.2	1.0	-0.4	0.2	-0.0
Mouth/teeth dental problems: Dentures	0.8	1.3	3.7	0.6	-0.3	1.0	1.9	-0.7	-0.1	1.7	1.8	-0.2	-0.5	-1.9	0.0	-1.4
Asthma	0.5	0.9	2.8	1.7	-0.4	-0.5	-0.8	-0.7	-0.9	-1.0	-1.1	-0.3	-1.6	0.4	-1.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	5.2	-2.3	-1.3	-2.2	-0.1	-2.2	-1.2	-1.6	-1.9	-1.3	-1.9	0.6	-1.9	-0.5
Medication: Cholesterol lowering	0.9	1.5	4.0	1.1	1.2	1.8	-0.1	1.0	0.6	1.8	2.0	1.2	0.4	-1.0	1.3	0.1
Depression (self-reported)	0.9	1.1	2.2	0.2	1.4	1.0	-0.1	1.1	0.9	0.9	0.8	1.5	1.2	0.5	1.4	1.2
Medication: Lansoprazole	1.5	1.7	4.9	-0.3	-0.1	1.4	-0.5	-1.6	1.1	1.8	1.9	-0.2	-2.0	-2.2	-0.4	-0.7
Prospective memory result	0.4	0.5	1.2	0.7	0.7	0.1	0.9	1.1	1.0	0.3	-0.1	0.8	0.4	0.9	0.5	0.3
Lung cancer (father)	2.3	2.6	7.3	-1.1	-2.2	-2.7	1.2	-0.9	-1.5	-1.9	-2.0	-2.3	-0.5	1.0	-1.3	-0.5
Illnesses of mother	0.4	0.4	1.9	-1.4	-0.1	-0.0	-1.1	0.0	-0.5	-0.4	-0.3	-0.1	1.0	-0.6	0.8	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	5.9	-2.4	0.1	-0.6	0.2	0.0	0.9	-1.3	-1.5	0.1	-0.0	1.5	-0.1	0.6
Pulse wave Arterial Stiffness index	0.8	0.9	3.2	1.8	-1.4	0.2	0.7	-1.3	-0.9	0.2	-0.1	-1.4	-0.8	-0.5	-0.7	-0.9
Impedance of arm (left)	0.6	2.8	14.0	-1.9	0.1	1.5	-0.4	0.0	1.8	2.2	2.2	0.4	-0.4	-3.7	-0.9	-1.4
Arm fat mass (right)	0.1	0.5	1.7	-0.3	0.0	-1.2	0.5	0.4	0.7	-0.4	-0.1	0.2	1.1	1.3	0.4	1.2
Trunk predicted mass	0.4	2.2	13.3	-0.0	1.4	0.4	-0.1	1.2	1.1	-0.1	-0.2	1.2	1.4	3.6	1.5	2.3
Standing height	0.4	4.3	10.7	-2.2	2.6	2.4	-0.3	2.0	3.3	1.9	1.6	2.5	1.7	1.7	1.6	1.8
Length of working week for main job	0.6	0.6	1.9	-0.8	0.7	-0.5	-0.6	0.5	0.5	-1.4	-1.4	0.5	1.0	0.7	0.5	0.4
Exposure to tobacco smoke at home	0.7	0.8	2.6	-0.3	-0.4	0.2	-0.3	-0.8	-0.2	1.0	1.0	-0.4	-1.6	-1.1	-1.4	-1.2
Breastfed as a baby	0.4	0.5	1.3	-0.0	0.7	0.2	-0.5	1.1	1.0	0.9	0.9	0.8	0.5	0.1	0.7	0.2
Tense / ‘highly strung’	0.2	0.3	1.7	-0.5	1.0	0.1	-0.1	0.7	1.3	0.0	-0.1	1.0	-0.0	0.2	-0.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.8	-0.6	-0.4	-0.3	-0.4	-0.3	0.1	0.3	0.4	-0.4	-0.6	0.1	-0.9	-0.3
Hair/balding pattern: Pattern 4	2.4	5.8	11.3	1.7	3.4	2.9	1.3	2.6	2.3	2.1	2.5	3.3	1.5	-0.7	3.1	2.2
Birth weight of first child	0.4	0.7	3.1	-0.2	-0.6	-0.5	-0.5	-1.0	0.1	-0.3	-0.3	-0.6	-1.0	-0.5	-1.3	-1.8
Peak expiratory flow (PEF)	0.2	0.4	1.2	0.2	0.4	0.2	-0.7	0.4	-0.4	-1.1	-1.1	0.4	0.3	0.6	0.3	0.7
Pulse wave reflection index	3.0	3.7	8.9	-0.5	-2.7	-1.3	-0.4	-3.0	-1.7	-1.1	-1.2	-2.8	-2.2	-2.3	-1.7	-1.6
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	0.1	-0.3	-0.7	-0.9	-0.4	0.9	0.3	0.1	-0.2	-0.1	0.8	-0.9	-0.3
Loud music exposure frequency	0.6	0.6	1.8	-1.1	0.5	0.2	-0.4	0.8	1.1	-0.4	-0.7	0.4	0.7	1.1	-0.0	1.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.6	-0.0	0.3	0.9	1.2	0.6	1.1	0.1	0.1	0.3	0.3	0.7	0.6	0.7
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	6.7	-1.4	-0.8	-1.2	2.6	0.3	-0.1	-1.4	-1.4	-0.8	0.2	2.6	-0.1	0.6
Blood clot in the leg (DVT)	1.0	1.3	4.5	1.1	1.1	1.2	0.7	0.6	0.4	1.6	1.6	1.2	0.8	-0.2	2.1	0.3
Medication: Paracetamol	0.1	0.2	0.5	-0.3	-0.2	-0.5	-0.1	-0.5	0.5	0.7	0.6	-0.1	0.2	0.2	0.4	0.1
Headache pain in last month	0.5	0.9	2.5	-1.4	-0.7	0.4	0.5	-1.3	-0.4	0.7	0.9	-0.6	-1.0	-1.6	-0.7	-1.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.3	-0.3	0.5	0.2	0.3	0.9	0.7	-0.6	-0.8	0.4	1.5	0.4	0.8	0.5
Glaucoma (self-reported)	0.7	0.9	2.2	0.5	-1.0	-0.2	1.2	-1.5	-0.9	0.7	0.5	-0.9	-1.5	-0.1	-0.8	-1.0
Gout (self-reported)	0.9	1.2	8.2	1.0	-0.9	-1.3	-2.9	-0.8	-0.6	-0.4	-0.3	-0.8	-1.4	-0.3	-0.8	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.4	-0.1	-0.6	0.1	0.4	-0.1	-0.6	0.2	0.1	-0.4	-0.1	0.3	-0.1	-0.3
Medication: Amlodipine	0.6	0.9	6.4	-0.6	0.2	0.5	2.5	-0.6	1.3	-0.1	-0.0	0.2	-1.3	-0.2	-0.8	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.6	-0.0	-0.1	0.1	-0.3	-0.2	-0.7	-0.0	0.0	-0.3	-0.3	0.1	-0.4	0.6
Birth weight	0.5	1.0	4.0	-1.6	0.7	1.3	-2.0	0.8	0.6	0.9	1.0	0.7	0.4	-0.7	-0.2	-0.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.8	0.6	-0.5	0.5	1.9	-0.5	-0.1	1.4	1.4	-0.5	0.4	-0.8	0.1	0.6
High blood pressure (siblings)	0.8	1.1	4.8	-1.4	-1.0	-0.8	2.2	-1.1	-1.3	-0.3	0.1	-0.9	-1.0	1.0	-0.2	-0.3
Forced vital capacity (FVC), Best measure	0.5	1.9	11.8	-3.4	-0.5	-1.1	0.8	-0.5	0.5	-1.8	-2.0	-0.6	-0.6	1.3	-0.7	0.2
Body fat percentage	0.1	0.3	1.3	0.0	-0.6	-1.2	0.8	-0.1	0.4	0.1	0.4	-0.4	0.4	-0.4	-0.7	-0.3
Leg fat percentage (right)	0.2	0.6	3.9	-0.3	-0.7	-2.0	0.5	0.1	-0.2	-1.0	-0.7	-0.6	1.0	0.8	-0.0	0.4
Arm fat-free mass (right)	0.4	1.9	13.0	0.0	0.7	-0.2	0.4	0.9	0.8	-1.0	-1.1	0.6	1.2	3.6	1.1	1.9
Exposure to tobacco smoke outside home	0.6	0.8	2.3	0.7	-0.9	-0.9	0.8	-0.9	-0.3	-1.1	-1.0	-1.0	-1.1	0.3	-1.5	-0.4
Comparative body size at age 10	0.4	1.2	2.9	-1.1	-0.7	-1.4	-1.7	-0.1	0.2	-1.6	-1.5	-0.7	0.8	1.5	0.3	0.5
Number of full brothers	0.6	0.7	2.5	-1.6	-0.4	0.6	1.3	-0.0	0.6	1.5	1.1	-0.4	0.8	-0.2	-0.5	0.2
Worry too long after embarrassment	0.3	0.5	1.6	-0.3	0.7	0.9	0.7	0.3	1.1	1.2	1.1	0.6	-0.1	-0.3	-0.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.5	-0.4	2.0	0.9	0.2	1.8	0.9	1.1	0.9	2.1	1.6	1.1	1.4	1.6
Wheeze or whistling in the chest in last year	0.6	1.1	2.6	0.9	-1.4	-1.3	0.3	-0.9	-1.6	-1.5	-1.2	-1.5	-0.4	-0.1	-0.7	-0.2
Number of children fathered	0.6	0.7	1.8	1.3	0.0	1.1	0.4	-0.0	-0.8	1.2	1.2	0.0	-0.7	-1.3	0.5	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.4	-0.1	0.2	-0.2	-1.0	0.4	-0.7	-0.3	-0.5	0.1	0.7	0.8	-0.1	1.2
Age at first live birth	2.4	4.2	9.8	0.3	3.1	2.1	-0.4	1.9	2.1	1.1	1.1	3.0	2.0	1.2	3.1	2.3
Pulse wave peak to peak time	1.2	1.4	4.0	-2.0	1.7	0.1	-0.8	1.6	1.3	0.1	0.4	1.7	1.0	0.7	0.9	1.1
Health satisfaction	0.7	0.9	4.5	0.3	-1.4	-2.1	0.2	-1.5	-0.2	-0.5	-0.7	-1.3	-0.4	0.7	-0.3	-0.4
Shortness of breath walking on level ground	0.7	0.9	4.3	0.4	-0.8	-1.9	0.0	0.0	-0.6	-0.8	-0.9	-0.7	0.1	2.1	-0.0	0.5
Qualifications: College or University degree	1.7	5.2	12.2	-1.2	2.9	0.3	-0.7	2.6	2.4	-0.4	-0.7	2.8	3.0	3.1	3.5	2.4
Eye problems/disorders: None of the above	0.1	0.1	0.5	0.7	0.2	0.7	-0.3	0.1	-0.2	0.2	0.4	-0.0	0.3	0.1	-0.0	0.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.9	0.9	0.6	1.1	-0.1	0.2	1.6	2.0	1.8	0.7	-0.7	0.3	-0.7	-0.6
Emphysema/chronic bronchitis	0.7	0.8	3.9	-0.0	-0.8	-0.1	0.5	-0.8	-1.4	0.2	0.6	-0.9	-0.8	-2.0	-0.8	-0.7
Medication for pain relief, constipation, heartburn	0.9	1.6	5.6	0.6	1.4	1.6	-0.1	2.4	0.8	0.7	0.6	1.4	1.4	0.6	1.5	1.4
Neck or shoulder pain in last month	1.9	2.7	7.4	1.5	-0.0	1.3	0.4	-1.1	-0.6	2.6	2.7	0.1	-2.0	-2.4	-1.2	-1.9
Medication: Blood pressure	0.3	0.5	1.5	-0.9	-0.5	-0.3	0.3	-1.0	-0.4	0.7	1.1	-0.3	-1.2	-0.0	-0.6	0.1
Angina (self-reported)	0.7	0.9	3.0	1.1	-0.9	-0.4	-0.6	-1.3	-0.9	0.1	-0.1	-0.8	-1.0	-1.3	-1.7	-0.9
Migraine (self-reported)	0.4	0.5	4.5	-0.7	0.4	-0.4	-0.3	0.5	-0.5	-0.0	-0.3	0.2	0.2	2.1	-0.4	0.3
Medication: Ibuprofen	1.9	2.2	4.2	-2.0	-1.1	-2.0	-0.3	-1.8	-0.9	-1.6	-1.9	-1.1	-1.6	1.2	-1.9	-0.4
Medication: Allopurinol	0.7	0.9	4.4	1.0	-1.1	-1.5	-2.1	-0.9	-0.4	-0.3	-0.2	-1.0	-0.4	-0.3	-0.2	-0.2
Medication: Omeprazole	1.6	1.9	4.7	-0.8	-1.3	-0.8	0.1	-2.2	-1.0	-1.0	-1.0	-1.3	-1.8	-1.8	-1.6	-1.7
Medication: Seretide 50 evohaler	0.4	0.5	1.7	0.7	0.1	0.7	0.6	0.6	0.4	1.3	1.2	0.1	0.3	0.6	0.0	0.6
Mean time to correctly identify matches	0.2	0.3	1.0	0.6	-0.1	0.6	1.0	0.7	0.7	0.2	0.6	-0.1	0.9	-0.1	0.5	0.2
Heart disease (mother)	0.1	0.2	0.9	-0.2	-0.2	-0.3	0.2	0.3	-0.3	0.1	0.3	-0.1	0.1	-0.5	-1.0	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	2.2	1.5	-0.3	0.1	-0.5	-0.4	0.2	-0.5	-0.4	-0.1	-0.3	-1.1	0.1	-0.6
Whole body fat mass	0.1	0.4	0.9	-0.2	-0.0	-0.9	0.9	0.4	0.8	0.0	0.3	0.1	0.9	1.0	0.1	0.6
Leg fat mass (right)	0.3	1.0	4.2	-0.4	-0.1	-1.5	0.6	0.6	0.6	-0.9	-0.7	-0.1	1.4	2.1	0.5	1.3
Arm predicted mass (right)	0.4	2.1	14.8	-0.1	1.0	-0.1	0.5	1.1	0.9	-0.7	-0.9	0.8	1.3	3.8	1.1	2.1
Pulse rate, automated reading	0.2	0.7	2.0	1.4	0.7	0.8	1.0	0.4	0.8	0.9	1.2	0.8	-0.2	-0.9	0.4	0.0
Alcohol intake frequency.	1.2	2.7	6.1	2.4	-2.1	-1.9	0.1	-2.5	-0.5	-0.3	-0.3	-1.9	-1.9	-0.8	-1.9	-2.0
Comparative height size at age 10	0.1	0.7	1.8	-0.6	0.5	1.3	-1.0	0.2	1.2	1.3	1.3	0.5	-0.2	0.8	-0.2	0.1
Number of full sisters	0.9	1.1	2.5	-0.6	-0.7	-0.1	-0.4	-1.2	-1.5	1.3	1.2	-0.7	-1.0	-0.6	-1.6	-1.4
Suffer from ‘nerves’	0.7	1.1	3.6	-1.0	-0.9	0.0	-0.1	-1.6	-0.5	-0.1	-0.1	-0.8	-1.6	-1.1	-1.9	-1.3
Overall health rating	1.7	3.6	9.1	0.9	-2.5	-1.6	1.6	-2.7	-1.2	0.6	0.9	-2.4	-2.7	-0.3	-3.0	-1.5
Chest pain or discomfort	0.6	0.8	2.8	0.4	-1.7	-1.4	0.0	-0.6	-0.8	-0.8	-0.6	-1.6	-0.2	-0.1	-1.0	0.2
Had major operations	0.3	0.4	1.6	1.0	0.4	0.4	0.3	0.6	-0.1	-1.3	-0.8	0.5	0.2	0.1	-0.4	0.3
Age at last live birth	1.8	2.6	7.5	0.3	2.0	2.7	0.7	0.6	0.8	2.7	2.7	2.0	0.4	-0.3	1.3	0.8
Family relationship satisfaction	0.2	0.2	0.9	-0.2	-0.4	-0.6	-0.1	-0.8	-0.8	-0.3	-0.2	-0.2	-1.0	0.3	0.0	-0.2
Leg pain on walking	0.7	0.8	2.5	-0.9	-0.9	-1.3	1.6	-0.8	0.8	-1.2	-1.0	-0.7	-1.0	0.3	-0.4	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.5	-1.2	0.2	0.5	-0.0	0.6	-0.5	0.7	0.5	0.2	0.5	-0.0	0.3	-0.0
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.2	0.9	-0.0	0.6	-0.7	0.3	-1.0	0.1	0.3	-0.2	0.3	-1.1	0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.9	-1.3	1.7	1.4	1.0	0.8	1.0	0.8	0.8	1.4	-0.3	-0.0	1.2	0.2
Medication: Aspirin	0.1	0.1	1.1	1.0	0.2	0.0	0.4	0.3	-0.1	0.2	0.2	0.3	0.3	0.4	0.1	-0.1
Supplements: Vitamin C	2.1	2.4	5.2	1.3	-2.0	-0.1	-0.6	-2.3	-1.7	-0.0	0.3	-2.0	-1.7	-1.9	-1.6	-2.1
Knee pain experienced in last month	0.4	0.6	2.5	-1.6	-0.8	-1.1	0.1	-0.3	1.1	-0.8	-0.5	-0.7	0.5	0.3	0.0	-0.0
Hypertension (Self-reported)	0.4	1.0	3.0	0.8	-1.1	-1.4	1.2	-1.4	0.5	0.1	0.3	-0.9	-1.4	0.4	-1.7	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.9	4.6	11.9	0.3	-2.4	-1.0	-1.4	-2.8	-1.1	-0.1	0.3	-2.3	-3.4	-2.7	-2.9	-2.9
Illnesses of father: Heart disease	0.9	1.3	3.5	0.2	0.7	-0.5	1.4	0.6	0.8	-0.7	-1.0	0.8	1.5	1.9	1.4	1.8
Illnesses of siblings: Diabetes	0.4	0.5	1.9	0.7	0.5	0.5	0.5	0.7	-0.7	-0.2	0.1	0.6	0.2	-0.1	1.2	1.4
Smoking status: Previous	0.9	1.4	3.2	0.2	0.9	1.4	1.8	1.6	-0.5	1.2	1.4	0.9	0.5	-0.2	1.5	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	7.6	-2.8	1.2	0.0	-1.2	0.9	2.1	0.2	-0.1	1.3	1.5	1.3	1.3	1.9
Whole body fat-free mass	0.4	2.4	13.9	-0.5	1.4	0.3	0.2	1.3	1.5	-0.1	-0.2	1.3	1.5	3.7	1.4	2.4
Leg fat-free mass (right)	0.4	2.1	10.3	-1.0	1.2	0.4	0.6	1.2	1.8	0.2	0.1	1.2	1.3	3.2	1.0	2.2
Arm fat percentage (left)	0.1	0.3	1.6	-0.1	-0.4	-1.3	0.7	0.3	0.5	-0.3	0.0	-0.1	0.7	0.2	-0.2	0.5
Average weekly red wine intake	0.8	1.2	3.7	0.0	1.3	0.7	-0.6	1.2	1.9	0.4	0.5	1.0	0.7	0.8	1.7	1.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.0	-0.8	0.2	-0.2	1.4	0.6	0.8	-0.8	-0.9	0.0	0.8	1.3	-0.2	0.3
Mood swings	0.6	1.2	3.1	0.5	0.8	1.1	0.6	1.5	-0.3	1.1	1.5	1.0	1.8	-0.7	1.4	0.6
Loneliness, isolation	0.7	1.0	3.1	-0.1	-0.5	0.4	1.2	0.4	0.3	1.8	1.7	-0.5	1.2	1.0	0.3	1.4
Long-standing illness, disability or infirmity	1.5	2.3	5.3	1.4	-2.3	-2.0	-0.4	-2.1	-1.7	-0.6	-0.8	-2.1	-1.5	-0.5	-1.6	-1.0
Ever had bowel cancer screening	3.5	4.1	12.8	2.0	-1.9	-0.3	0.5	-2.0	-3.1	0.1	0.5	-2.0	-1.2	-3.6	-2.4	-2.9
Diabetes diagnosed by doctor	0.7	1.1	5.8	-0.5	-0.1	0.9	-0.5	-1.1	-0.2	1.1	1.1	0.0	-1.8	-2.4	-0.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.6	-0.1	0.4	0.2	-0.8	-0.5	0.4	-0.5	-0.7	0.7	-0.2	0.7	-0.3	0.6
Friendships satisfaction	0.4	0.6	2.4	1.6	-0.1	0.5	0.5	-0.3	-0.4	0.9	1.2	0.0	-1.3	-0.0	-0.2	-0.2
Qualifications: nursing, teaching	0.8	1.2	8.5	0.4	1.2	-0.1	-2.9	0.3	1.0	-1.0	-1.0	1.2	0.2	0.6	0.6	0.3
Commuting to job workplace: Walk	1.5	1.6	4.1	-1.1	-1.6	-1.2	0.0	-1.9	0.1	-0.3	-0.6	-1.6	-1.5	-1.1	-2.0	-1.3
Eye problems/disorders: Cataract	0.4	0.5	2.5	-0.3	0.2	-0.3	-1.4	-0.0	-0.5	0.1	0.1	0.3	-0.5	-1.6	-0.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	4.0	1.1	1.2	2.0	-0.7	0.3	1.1	1.2	1.2	1.2	-0.3	-1.3	0.8	-0.1
Medication for cholesterol	0.2	0.4	1.8	-1.3	0.6	0.7	-0.9	0.7	0.0	0.1	0.0	0.6	0.1	-0.5	0.5	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.4	0.7	-0.0	0.3	0.0	-0.2	0.4	1.1	1.2	0.1	0.7	0.1	0.8	0.4
Back pain experienced in last month	0.4	0.6	2.0	-0.0	-1.4	-1.0	0.1	-0.7	-1.3	-1.0	-0.9	-1.2	-0.3	-0.1	0.1	0.6
Mineral and other dietary supplements	0.1	0.1	0.4	-0.2	-0.2	-0.6	0.3	-0.1	0.5	0.1	0.0	-0.3	-0.6	0.6	-0.3	0.0
Breast cancer (self-reported)	0.2	0.3	1.0	-0.0	0.0	-0.3	0.3	-1.0	-0.2	0.8	0.8	0.2	-1.0	-0.0	-0.2	-0.6
Asthma (self-reported)	0.5	1.0	2.8	1.4	-0.5	-0.6	-1.0	-0.8	-0.9	-1.2	-1.3	-0.3	-1.7	0.2	-1.4	-0.3
Osteoporosis (self-reported)	1.1	1.4	4.2	2.1	0.9	1.8	0.4	0.3	1.9	1.5	1.4	0.9	-0.6	-0.4	0.1	-0.2
Osteoarthritis (self-reported)	2.0	2.6	7.5	0.5	-1.4	-0.3	-1.5	-2.6	-1.5	0.7	0.9	-1.3	-2.4	-2.7	-1.1	-1.5
Medication: Aspirin	0.1	0.2	1.3	1.2	0.0	-0.0	0.4	0.2	-0.4	0.1	0.1	0.1	0.1	0.5	-0.3	-0.2
Medication: Gliclazide	0.3	0.3	2.7	-0.6	-0.2	-0.7	-1.6	-0.1	0.3	-0.4	-0.6	0.0	-0.4	-0.4	0.2	0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.2	0.7	0.5	-0.7	1.1	0.8	0.8	0.8	0.5	0.7	-0.3	0.9	0.5
Smoking status: Current	0.3	0.5	3.6	0.8	-0.1	-0.1	-1.9	-0.5	-0.5	-0.2	-0.7	0.1	-1.1	0.0	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.8	-1.5	-1.2	-1.4	0.7	-0.7	0.4	-1.9	-1.9	-1.2	-0.7	0.2	-0.8	-0.5
Whole body water mass	0.4	2.4	13.3	-0.5	1.4	0.4	0.3	1.3	1.4	-0.1	-0.2	1.3	1.5	3.7	1.4	2.4
Leg predicted mass (right)	0.4	2.1	10.3	-1.0	1.3	0.5	0.6	1.3	1.7	0.3	0.2	1.3	1.4	3.2	1.0	2.2
Arm fat mass (left)	0.1	0.5	1.6	-0.2	0.1	-1.1	0.6	0.5	0.7	-0.4	-0.2	0.2	1.0	1.3	0.3	1.1
Number of self-reported non-cancer illnesses	0.7	1.1	3.5	1.5	0.9	1.0	0.4	0.1	1.2	1.8	1.9	1.2	-0.7	0.5	0.2	0.4
Average weekly champagne plus white wine intake	1.0	1.3	4.2	-0.8	1.6	0.7	-0.2	1.6	2.0	0.2	-0.2	1.4	1.4	1.1	0.9	0.8
Miserableness	1.5	2.6	5.5	-1.2	1.7	1.5	0.7	2.0	0.4	1.7	2.0	1.9	2.4	0.4	2.1	1.4
Guilty feelings	0.1	0.1	0.5	-0.2	0.1	-0.2	-0.5	-0.1	0.7	0.4	0.4	0.1	0.3	-0.6	0.2	-0.4
Wears glasses or contact lenses	1.1	1.3	3.5	0.2	1.9	1.5	0.3	1.5	1.3	0.7	0.7	1.6	1.5	0.8	0.8	0.7
Ever taken oral contraceptive pill	1.9	2.1	4.5	-0.9	1.9	0.9	0.4	1.7	1.4	0.7	0.5	2.0	1.0	1.8	2.0	2.1
Hearing aid user	1.1	1.3	3.2	-0.2	1.7	1.5	1.3	0.8	1.0	1.5	1.5	1.8	-0.1	-0.2	0.2	-0.5
Mother’s age at death	1.5	1.9	4.6	1.8	1.5	1.4	-0.9	1.3	1.5	1.2	1.3	1.6	1.3	-0.4	2.1	-0.1
Financial situation satisfaction	0.4	0.4	2.0	-0.3	0.5	-0.1	1.2	0.4	1.4	0.6	0.4	0.6	0.2	0.3	0.5	0.7
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.1	0.2	-0.7	0.6	1.8	-0.7	-1.7	1.2	1.7	-0.7	-0.4	-1.1	-0.6	-0.9
Commuting to job workplace: Public transport	0.3	0.4	0.9	-0.7	0.3	0.7	1.0	0.5	0.8	0.6	0.5	0.4	-0.1	0.9	-0.3	0.2
Eye problems/disorders: Glaucoma	1.0	1.2	6.1	0.6	-1.2	-1.0	2.5	-1.4	-0.7	-0.2	-0.1	-1.3	-0.7	0.3	-0.8	-1.0
Medication: Blood pressure	0.4	0.7	2.8	1.7	-0.0	-1.1	0.5	0.2	0.9	-0.6	-0.5	0.1	0.5	1.1	-0.5	1.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	-0.8	-0.8	-0.4	0.2	-0.9	0.5	0.4	0.4	-0.8	0.0	0.0	0.0	0.1
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.8	0.4	-1.3	-0.2	-0.3	-1.5	-1.9	-0.4	-0.2	-1.4	-0.8	-1.8	-1.5	-1.5
High cholesterol (Self-reported)	0.7	1.2	4.3	0.8	0.1	1.5	0.1	-0.9	-0.1	1.9	2.1	0.1	-1.1	-1.6	-0.4	-0.7
Medication: Bendroflumethiazide	1.1	1.7	3.7	-0.0	-1.9	-1.6	0.9	-1.0	-0.7	-1.9	-1.7	-1.8	-0.5	-0.6	-1.4	-0.9
Medication: Paracetamol	0.1	0.2	0.9	0.4	0.2	-0.9	-0.4	-0.2	0.5	0.3	0.1	0.3	0.5	0.7	0.4	0.5
Medication: Lisinopril	0.2	0.3	1.0	-0.4	-0.8	-1.0	-0.6	-0.8	-0.3	0.2	0.1	-0.7	-0.8	-0.3	-0.2	0.1
Medication: Atorvastatin	1.1	1.4	3.3	0.3	-1.8	-1.1	0.3	-1.6	-1.6	-0.6	-0.3	-1.8	-0.9	-0.1	-1.3	-1.5
Illnesses of father: High blood pressure	1.0	1.2	2.4	-1.4	-1.2	-1.6	1.3	-1.4	-1.0	-1.2	-1.0	-1.1	-1.1	0.1	-0.7	-0.6
Alcohol drinker status: Never	1.7	2.0	6.1	1.5	-1.5	-1.7	-0.4	-1.5	-0.0	-1.3	-1.6	-1.6	-1.2	0.4	-2.5	-1.2
Ever smoked	2.1	3.7	8.8	-0.3	2.4	2.0	1.2	2.7	1.0	1.4	1.1	2.3	1.5	1.9	2.4	3.0
Basal metabolic rate	0.4	2.2	12.5	-0.6	1.2	0.1	0.3	1.2	1.4	-0.2	-0.3	1.1	1.6	3.5	1.2	2.3
Leg fat percentage (left)	0.2	0.8	4.8	-0.2	-1.1	-2.2	0.7	-0.4	-0.6	-1.1	-0.8	-1.0	0.4	0.2	-0.5	-0.1
Arm fat-free mass (left)	0.3	1.4	10.5	0.1	0.7	-0.2	0.2	0.7	0.6	-0.7	-0.8	0.5	1.1	3.2	0.9	1.8
Number of operations (self-reported)	0.5	0.8	3.3	1.8	-0.4	-0.6	-1.5	-0.2	-0.6	-0.4	-0.5	-0.4	-0.8	-0.4	-1.2	-0.9
Average weekly beer plus cider intake	1.1	1.7	6.4	0.0	0.8	2.5	1.2	0.7	0.4	2.2	2.4	0.8	0.5	-0.9	-0.2	0.5
Irritability	0.9	1.4	5.0	0.1	-0.3	1.0	-0.9	-0.6	-0.4	1.8	1.8	-0.1	-1.5	-2.2	-1.2	-1.0
Risk taking	0.4	0.6	3.5	0.3	-0.0	-1.0	-0.4	0.3	-0.1	-0.8	-1.0	-0.0	0.8	1.9	0.4	0.8
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.5	1.2	0.6	0.3	0.3	1.6	0.7	0.5	0.6	0.7	1.2	0.8	0.8	0.3
Fractured/broken bones in last 5 years	0.8	1.0	4.4	-0.9	0.9	0.7	-0.5	0.7	0.4	-0.4	-0.4	1.1	2.1	-0.8	2.0	0.3
Age started oral contraceptive pill	0.4	0.5	1.7	0.4	0.4	0.9	0.5	-0.2	0.7	1.2	1.3	0.5	-0.3	-1.0	0.1	-0.1
Diastolic blood pressure, automated reading	0.2	0.8	2.5	0.0	-0.9	-1.3	1.6	-0.7	-0.3	-0.9	-0.3	-0.8	-1.1	0.2	-1.1	0.3
Ever depressed for a whole week	0.4	0.6	1.9	0.9	-0.5	-0.7	-0.7	-0.4	-0.8	-0.6	-0.7	-0.6	-0.9	0.8	-1.4	-0.2
Unable to work because of sickness or disability	0.6	0.8	3.8	-0.7	-0.8	-0.2	2.0	-0.9	1.4	0.4	0.5	-0.6	-0.8	0.6	-0.9	-0.0
Commuting to job workplace: Cycle	1.4	1.7	5.3	-1.4	0.4	-0.1	0.0	1.4	1.2	-1.0	-1.0	0.4	2.0	2.3	1.4	1.6
Myopia	4.0	5.8	14.7	0.9	2.6	3.8	-0.8	1.4	2.8	3.6	3.5	2.6	0.6	-2.3	1.9	0.9
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.3	-0.5	1.0	1.4	-1.5	0.9	-0.2	0.0	-0.2	0.8	0.7	-0.7	1.2	-0.7
Cholesterol lowering medication	0.5	0.8	3.7	0.7	-0.5	0.1	0.3	-1.2	-0.5	0.2	0.4	-0.5	-0.8	-1.9	-1.1	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.9	-1.0	-0.7	-0.3	0.2	-1.6	-1.1	-0.2	-0.1	-0.8	-1.3	-1.7	-1.1	-1.4
Pain experienced in last month	0.5	0.8	3.1	1.2	0.6	-0.7	-1.2	0.9	0.1	-0.8	-1.2	0.5	0.2	1.8	0.0	0.5
Supplements: Calcium	0.8	0.9	2.6	-0.7	0.6	0.1	1.3	0.5	1.2	0.7	0.6	0.7	1.5	1.1	1.6	0.6
Basal cell carcinoma (self-reported)	0.6	0.8	3.3	-0.3	-0.1	-0.5	-0.9	0.4	-1.0	-1.8	-1.8	-0.0	0.6	-0.8	-0.0	-0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.7	0.5	-0.2	0.2	1.5	-0.6	-0.3	1.5	1.6	-0.2	0.0	-1.6	0.3	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.8	1.5	0.9	1.1	0.4	0.5	0.4	1.6	1.6	1.0	0.8	-0.5	2.0	0.1
Heart disease (siblings)	1.0	1.2	3.1	-0.5	-0.8	-1.8	1.0	0.3	-1.0	-1.4	-1.2	-0.6	1.6	1.2	1.1	-0.3
Alcohol drinker status: Previous	0.2	0.3	1.0	1.0	-0.6	-0.4	1.0	-0.1	-0.5	0.4	0.4	-0.7	-0.2	0.1	0.0	-0.3
Pack years of smoking	0.5	0.8	3.0	-0.4	0.5	1.1	1.6	0.7	0.5	1.5	1.7	0.5	0.0	0.0	-0.1	-0.2
Impedance of whole body	0.4	2.3	14.7	-1.2	-0.3	1.0	-1.0	-0.5	0.9	1.5	1.4	-0.2	-0.8	-3.8	-1.3	-2.0
Leg fat mass (left)	0.2	0.7	2.7	-0.2	-0.4	-1.7	0.6	0.2	0.4	-0.9	-0.7	-0.3	1.0	1.6	0.1	0.9
Arm predicted mass (left)	0.3	1.4	10.7	0.1	0.7	-0.3	0.0	0.6	0.4	-0.8	-0.9	0.5	1.1	3.3	0.8	1.8