Hub : Genes

FMN1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.2240 0.0710 3.2e-03 0.016 NA 0.041 NA 0.027 4.7e-02 NA 3.7e-03 NA 1.5e-02
2 GTEx Esophagus Mucosa 0.1410 0.0510 3.7e-03 0.173 NA 0.170 NA 0.172 1.1e-11 NA 1.9e-11 NA 1.3e-11
3 GTEx Skin Sun Exposed Lower leg 0.1560 0.0520 1.6e-03 0.066 NA 0.068 NA 0.066 3.6e-06 NA 2.7e-06 NA 3.7e-06
4 GTEx Testis 0.2840 0.0850 7.0e-04 0.021 NA 0.030 NA 0.034 3.9e-02 NA 1.7e-02 NA 1.2e-02
5 GTEx Thyroid 0.3860 0.0530 4.9e-14 0.199 NA 0.226 NA 0.236 3.6e-15 NA 2.9e-17 NA 4.9e-18
6 GTEx Whole Blood 0.0890 0.0340 7.2e-03 0.037 NA 0.042 NA 0.039 2.4e-04 NA 9.2e-05 NA 1.5e-04
7 METSIM Adipose 0.1238 0.0275 1.0e-09 0.122 0.076 0.113 0.116 0.117 8.1e-18 1.7e-11 1.8e-16 5.9e-17 4.9e-17
8 NTR Blood 0.3325 0.0280 0.0e+00 0.419 0.369 0.426 0.423 0.425 9.3e-149 1.2e-126 4.0e-152 1.2e-150 1.5e-151
9 TCGA Head and Neck Squamous Cell Carcinoma 0.0455 0.0204 7.2e-03 0.045 0.019 0.045 NA 0.040 7.1e-06 3.0e-03 8.4e-06 NA 2.5e-05
10 TCGA Kidney Renal Clear Cell Carcinoma 0.0430 0.0202 8.7e-03 0.013 0.021 0.000 NA 0.004 1.2e-02 1.6e-03 3.6e-01 NA 1.1e-01
11 TCGA Lung Adenocarcinoma 0.0593 0.0218 8.4e-04 0.014 0.031 0.012 NA 0.018 8.5e-03 1.3e-04 1.3e-02 NA 3.2e-03
12 TCGA Prostate Adenocarcinoma 0.1416 0.0342 2.2e-10 0.107 0.115 0.072 NA 0.102 2.8e-11 5.4e-12 5.4e-08 NA 8.2e-11
13 TCGA Thyroid Carcinoma 0.1770 0.0410 8.7e-10 0.070 0.121 0.104 NA 0.106 2.2e-07 8.5e-12 2.6e-10 NA 1.8e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.4 0.7 1.5 -1.2 -1.2 -0.3 0.8 -1.1 -0.3 0.6 0.7 -1.0 -0.6 0.2 -0.7 -1.1
Bipolar Disorder or Schizophrenia 0.4 1.1 3.2 0.7 -1.8 -0.6 1.6 -0.4 -1.2 0.2 0.3 -1.6 -0.3 1.3 -0.7 -0.8
Depressed Affect (Nagel 2018) 0.6 1.3 4.2 -0.3 0.3 1.0 1.5 0.5 -0.5 1.5 2.0 0.5 1.6 -1.1 1.5 0.9
Depression (Nagel 2018) 0.5 0.8 1.6 -1.3 0.8 0.6 -1.2 0.1 0.7 1.0 0.9 0.9 1.2 -0.1 1.2 0.8
Intelligence (Savage-Jansen 2018) 1.8 5.5 11.8 -1.3 3.4 2.6 -0.4 2.8 2.7 1.2 0.6 3.4 2.5 1.5 3.1 2.2
Neuroticism (Nagel 2018) 0.7 1.6 5.8 -0.0 0.6 1.5 0.9 0.1 0.9 2.1 2.4 0.8 0.6 -2.0 1.2 0.2
Schizophrenia (2018) 0.5 1.0 3.2 1.8 -1.3 -0.6 1.4 0.4 -1.3 -0.2 -0.1 -1.3 0.2 1.6 -0.4 -0.1
Schizophrenia vs Biploar Disorder 0.9 1.2 2.5 -0.7 0.4 -0.8 -1.0 1.2 0.1 -1.2 -1.4 0.3 1.6 1.5 0.9 1.4
Worry (Nagel 2018) 0.4 0.9 4.1 -0.6 0.1 0.6 0.0 -0.9 1.4 1.0 1.2 0.2 -1.0 -2.0 -0.5 -0.7
Alzheimer’s Disease (in mother) 1.3 1.5 3.4 1.8 -0.8 -1.2 1.5 -1.3 -0.7 -1.6 -1.6 -1.1 -1.1 0.1 -1.3 -1.1
Alzheimer’s Disease (in father) 0.8 0.9 3.3 0.6 0.5 1.8 -0.4 0.5 1.8 1.2 1.2 0.6 -0.3 -0.3 0.5 0.3
Alzheimer’s Disease (including proxy) 0.8 1.2 4.1 1.6 -1.1 -0.2 0.3 -1.4 0.2 -0.2 -0.2 -1.1 -2.0 -0.9 -1.4 -1.1
Crohns Disease (2017) 0.5 1.1 3.0 0.3 1.0 0.7 0.7 1.6 1.2 0.3 0.1 0.9 1.6 1.7 0.7 1.1
Irritable Bowel Disease (IBD) 0.2 0.4 1.7 -0.2 0.3 0.4 1.2 0.5 -0.4 0.4 0.2 -0.0 0.8 1.3 0.1 0.4
Ulcerative Colitis (UC) 0.2 0.4 2.7 -0.1 -0.0 0.1 1.6 -0.1 -1.5 0.1 0.2 -0.3 0.1 0.8 -0.1 0.2
Major Depression (MDD) 0.2 0.2 0.6 -0.2 0.6 -0.7 -0.5 0.2 -0.3 0.1 0.1 0.8 0.8 0.5 0.7 0.2
Reaction Time 0.2 0.3 1.0 -0.6 -0.3 -0.3 0.1 0.3 1.0 -0.9 -0.7 -0.2 0.6 0.4 0.1 0.3
Verbal and Numeric Reasoning (VNR) 2.8 6.7 14.3 -1.8 3.8 2.7 0.4 3.4 1.6 1.5 1.0 3.7 3.2 1.7 3.5 2.4
Breast Cancer 0.4 1.0 3.1 0.9 0.5 -0.7 -0.1 0.7 -0.4 -1.6 -1.4 0.4 1.3 1.8 1.0 0.8
Ovarian Cancer 0.5 0.7 2.2 0.3 0.6 1.5 0.4 0.3 1.4 1.0 1.1 0.7 0.4 -0.2 1.0 0.7
Prostate Cancer 5.3 7.4 14.4 -0.6 -3.8 -2.6 -0.6 -3.7 -3.5 -1.3 -1.2 -3.8 -2.5 -1.8 -3.6 -3.0
Age at First Birth 1.6 2.3 9.8 -2.3 2.0 1.2 -0.2 1.0 3.1 1.1 0.8 2.0 0.5 0.7 0.9 1.2
Bipolar Disorder (2011) 0.9 0.9 4.5 0.2 -0.0 1.0 2.1 -0.4 0.8 0.8 0.7 -0.1 -1.4 0.6 -1.2 -0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.6 1.3 -0.2 -0.1 -1.1 0.0 -0.3 -1.2 -0.9 -0.2 -0.2 -0.5 0.1 -0.0
Coronary Artery Disease (CAD) 0.6 0.7 3.1 -1.8 0.3 0.3 0.8 -0.1 1.4 0.6 0.7 0.2 0.5 0.8 0.4 1.2
Crohns Disease (2012) 0.2 0.3 1.6 0.0 0.4 0.6 -0.3 0.6 1.3 0.7 0.3 0.1 -0.2 0.7 -0.6 0.4
Mean Putamen Volume 0.2 0.3 0.8 0.4 0.4 0.4 -0.9 -0.1 -0.3 0.7 0.7 0.5 -0.3 -0.9 0.1 -0.1
Fasting Glucose 0.3 0.4 1.7 0.2 -0.1 0.2 -1.3 0.3 -1.3 -0.6 -0.1 0.1 0.4 -1.0 0.2 -0.2
HbA1C 0.5 0.5 1.5 0.8 -0.6 -0.5 0.0 -1.2 -0.5 -0.5 -0.4 -0.7 -0.8 -0.7 -0.7 -1.1
HDL Cholesterol 0.2 0.3 1.0 -0.9 0.4 0.7 0.4 0.3 -0.4 0.8 1.0 0.4 -0.2 0.1 -0.1 0.0
LDL Cholesterol 0.1 0.1 0.4 -0.0 0.4 -0.4 0.1 0.2 0.5 -0.4 -0.6 0.5 -0.4 -0.2 -0.2 -0.0
Lupus 0.7 1.1 2.4 0.5 1.0 1.5 -1.5 0.7 -0.8 0.9 1.0 1.1 1.1 -0.9 1.3 0.8
Neuroticism (2016) 1.5 2.2 4.1 -0.2 1.3 1.5 0.8 1.3 1.7 1.9 1.8 1.5 1.9 0.2 2.0 1.4
Primary Biliary Cirrhosis 0.2 0.3 1.0 0.5 0.2 -0.3 0.4 1.0 -0.3 -0.7 -0.3 0.1 0.4 0.8 -0.3 -0.6
Rheumatoid Arthritis 0.6 0.8 3.0 -0.8 1.1 1.7 0.3 0.7 0.2 0.8 0.6 1.1 -1.0 0.7 -0.3 1.0
Schizophrenia (2014) 0.6 1.4 6.4 0.7 -1.0 -1.1 1.3 0.7 -1.2 -1.1 -1.2 -1.0 1.3 2.5 0.0 0.2
Triglycerides 0.4 0.6 1.9 0.1 -1.3 -0.6 0.1 -0.6 -0.9 -0.8 -0.7 -1.4 -0.4 -0.7 -0.7 -0.3
Type 2 Diabetes (T2D) (2012) 0.2 0.2 1.2 -0.4 -0.6 -1.1 0.5 -0.6 -0.0 -0.4 -0.3 -0.6 0.1 -0.1 -0.2 -0.1
Ulcerative Colitis 0.2 0.2 1.0 0.4 0.2 -0.1 -0.0 0.2 -0.9 -0.3 -0.3 -0.0 0.9 1.0 0.3 0.4
Blood Eosinophil Count 0.0 0.3 0.8 -0.3 -0.6 -0.5 0.9 -0.6 0.6 0.5 0.6 -0.8 0.4 -0.6 -0.4 -0.1
Blood Platelet Count 0.2 2.6 8.0 -1.4 -1.8 -2.3 0.3 -1.6 -0.2 -2.8 -2.8 -1.7 -0.4 -0.5 -1.3 -0.3
Blood Red Count 1.1 10.4 38.4 1.4 3.3 6.2 0.2 3.2 2.1 4.9 5.0 3.3 1.6 -1.3 1.6 1.6
Blood White Count 0.2 1.7 11.2 0.5 -1.1 -0.4 -0.8 -1.5 -0.6 -0.1 0.3 -1.0 -1.2 -3.3 -1.0 -1.6
Heel T-Score 0.3 2.2 8.2 -2.9 -1.4 -1.8 1.6 -1.3 -0.3 -1.8 -1.5 -1.4 -0.8 -0.9 -1.0 -1.2
BMI 0.2 1.2 5.3 -0.1 -0.7 -2.3 0.4 -0.2 -0.1 -1.6 -1.7 -0.6 0.8 1.6 0.4 0.6
Height 0.3 4.8 10.8 -0.6 2.2 1.6 1.9 2.6 3.3 1.1 1.2 2.2 2.4 3.1 2.0 2.7
Waist Hip Ratio (WHR) 0.2 0.9 3.3 -0.1 0.8 1.0 -0.2 1.1 1.2 1.2 1.2 0.8 0.7 -1.8 -0.0 -0.2
Systolic Blood Pressure 0.3 1.4 11.5 -0.6 -0.4 -0.6 3.4 -0.6 1.1 -0.4 -0.0 -0.5 -0.6 1.0 -1.5 -0.4
Smoking Status 0.3 0.8 3.7 -0.7 -0.1 0.1 -1.0 -0.2 -1.6 -0.2 -0.5 -0.0 -1.4 -1.9 -0.3 -0.2
Allergy or Eczema 0.7 1.7 4.1 -0.6 1.5 1.6 -0.2 1.7 1.5 0.2 0.2 1.5 2.0 0.2 1.4 1.9
Cardiovascular Disease 0.1 0.5 2.0 0.6 -0.4 -1.0 0.8 -0.8 0.5 -0.2 -0.1 -0.2 -1.4 0.5 -0.7 0.4
Hypothyroidism (self reported) 0.2 0.6 2.2 1.2 0.2 0.8 1.5 0.9 0.4 -0.4 -0.3 0.5 0.5 0.9 0.7 0.2
Respiratory disease 0.3 0.7 1.5 0.9 0.7 0.5 -0.4 1.0 0.5 -1.2 -1.2 0.8 0.6 1.2 0.5 1.0
Type 2 Diabetes (T2D) (2018) 0.7 1.3 5.6 -1.5 -0.2 0.6 -1.6 -1.0 -0.0 1.1 0.9 -0.2 -1.4 -2.4 -0.4 -0.6
Lung FEV1/FVC ratio 0.4 1.8 4.8 1.3 1.2 1.5 -1.8 0.7 0.9 2.2 2.0 1.4 0.6 -0.2 1.3 0.5
Lung FVC 0.9 4.8 12.5 -2.8 -2.3 -2.9 0.6 -1.8 -2.0 -3.5 -3.3 -2.4 -1.4 -0.2 -1.4 -0.3
Neuroticism 0.2 0.4 1.3 -0.4 -0.0 0.3 1.0 -0.1 0.3 1.0 1.1 -0.0 0.2 -1.2 -0.3 -0.6
Chronotype (morning person) 0.5 1.2 5.8 -1.5 -0.4 -0.4 2.4 0.7 0.2 -0.7 -0.6 -0.2 1.0 1.8 0.8 0.9
Hair Pigment 0.1 1.8 4.6 -1.5 0.2 -1.2 -0.3 0.8 1.7 -1.2 -1.2 0.2 1.7 2.1 1.8 1.7
Tanning 0.1 0.7 1.8 -0.4 0.7 1.1 -0.5 1.3 0.6 1.4 1.0 0.6 1.2 0.2 -0.1 -0.2
Hand grip strength (left) 0.4 1.1 2.7 -0.6 -1.0 -1.0 -0.2 -1.1 -1.0 -1.1 -1.3 -1.1 -1.0 1.6 -0.7 -0.8
Number of treatments/medications taken 0.1 0.2 0.9 0.4 -0.2 0.1 0.2 -0.6 -0.3 0.6 0.7 -0.0 -0.9 -0.0 -0.5 -0.2
Average weekly spirits intake 0.6 0.8 2.7 0.5 1.0 0.4 -0.3 1.7 0.2 -0.5 -0.5 1.1 1.2 0.7 1.4 0.3
Sensitivity / hurt feelings 0.6 1.0 4.4 0.1 0.4 0.8 1.5 0.4 1.1 2.0 2.1 0.6 -0.2 0.1 0.4 0.1
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.3 -0.1 0.8 0.5 -0.3 0.7 0.4 1.1 1.1 1.0 0.7 -0.0 0.7 0.8
Hearing difficulty/problems: Yes 1.3 2.0 4.2 1.9 -1.7 -1.4 -0.8 -2.0 -1.3 0.3 0.5 -1.6 -1.6 -1.1 -1.6 -1.1
Relative age of first facial hair 0.5 1.0 1.9 -1.4 -1.2 -0.8 -0.5 -1.2 -1.3 -0.8 -0.9 -1.2 -1.1 -0.7 -0.7 -0.7
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 5.3 1.3 -0.4 0.1 -2.3 -0.4 -0.5 -0.7 -1.4 -0.4 -1.2 -0.4 -1.1 -0.6
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.9 0.2 -1.0 -0.7 0.2 -0.6 -0.0 0.4 0.3 -1.0 0.2 -0.4 -0.3 -0.8
Ever had hysterectomy (womb removed) 0.5 0.6 3.5 0.8 -0.9 -0.9 1.9 0.2 0.0 -0.0 0.2 -0.8 -0.4 0.3 0.5 -0.6
Systolic blood pressure, automated reading 0.3 1.0 5.7 1.0 -1.0 -1.1 2.4 -0.8 -0.1 -0.4 0.1 -0.9 -0.6 0.5 -1.0 -0.6
Eye problems/disorders: Diabetes related eye disease 2.1 2.3 4.5 -1.8 -1.8 -1.3 -0.1 -1.9 -0.3 -0.9 -1.0 -1.6 -2.0 -1.0 -2.1 -1.8
Angina 0.8 1.1 3.1 0.9 -1.0 -0.2 -0.4 -1.4 -1.1 0.3 0.2 -0.9 -1.2 -1.7 -1.8 -1.0
Medication for hormone replacement therapy 0.7 0.8 2.3 -0.5 -1.4 -0.8 -0.7 -1.5 -1.1 0.4 -0.0 -1.3 -0.6 0.0 -0.7 -0.7
Vitamin and mineral supplements 1.2 1.6 2.9 -0.9 1.7 0.9 1.2 1.2 1.2 1.6 1.6 1.7 0.6 0.5 1.3 1.4
Supplements: Zinc 0.2 0.2 0.7 0.8 -0.3 -0.4 -0.7 0.3 0.4 -0.1 0.2 -0.1 0.5 -0.2 0.8 0.6
Medication: Co-codamol 1.5 1.8 6.9 0.5 -1.2 -2.2 -0.7 -0.5 -2.6 -1.4 -1.5 -1.1 0.3 -0.4 -0.6 -1.6
Medication: Metformin 0.7 1.0 3.0 -1.0 0.7 1.3 -0.8 -0.1 1.0 1.4 1.3 0.8 -0.7 -1.7 0.4 0.3
Diabetes (father) 0.6 0.8 1.7 1.0 -0.5 -0.6 -1.1 -0.2 -1.2 -1.0 -1.1 -0.5 0.1 -0.8 -0.8 -1.3
Diabetes (mother) 0.5 0.7 2.4 0.4 0.6 0.7 -0.4 0.8 0.9 1.2 1.1 0.7 0.1 0.2 0.6 1.6
Severe depression (siblings) 0.4 0.4 2.8 1.7 -0.3 -0.2 -0.5 0.1 0.2 -0.6 -0.5 -0.3 0.1 0.2 1.2 0.1
Pack years adult smoking proportion 0.4 0.7 2.2 -1.2 0.3 0.9 1.3 0.5 0.5 1.3 1.5 0.3 -0.0 0.1 -0.2 -0.3
Impedance of leg (right) 0.2 0.9 6.2 -0.8 -0.6 -0.0 -1.3 -0.4 0.0 -0.2 -0.3 -0.5 -0.3 -2.5 -0.7 -1.4
Leg fat-free mass (left) 0.6 3.0 14.1 -1.0 1.5 0.4 0.5 1.6 2.0 0.2 0.1 1.6 1.9 3.8 1.4 2.6
Trunk fat percentage 0.1 0.4 1.1 -0.3 -0.7 -0.8 0.9 -0.3 0.6 0.5 0.8 -0.4 -0.0 -0.8 -1.1 -0.6
Hand grip strength (right) 0.2 0.5 4.1 -0.5 -0.4 -0.5 -0.1 -0.3 -0.1 -0.6 -0.8 -0.4 -0.4 2.0 0.1 -0.2
Townsend deprivation index at recruitment 0.7 0.9 6.2 0.1 -0.6 -0.6 1.3 -1.0 -0.8 0.0 0.1 -0.7 -1.0 0.3 -2.5 -0.6
Current tobacco smoking 0.4 0.7 5.8 0.7 0.1 0.1 -2.4 -0.3 -0.1 -0.1 -0.6 0.2 -1.2 0.1 -0.6 -0.2
Average weekly fortified wine intake 2.7 3.1 6.2 0.6 2.2 1.9 0.5 2.5 1.8 0.9 0.6 2.3 2.2 1.6 2.4 1.7
Maternal smoking around birth 0.6 0.8 2.3 -0.1 -1.1 -1.0 -0.6 -0.7 -1.0 -0.4 -0.7 -1.2 -0.7 1.5 -1.4 -0.2
Fed-up feelings 0.8 1.4 5.9 -0.1 0.7 1.3 1.2 0.7 0.3 2.1 2.4 0.9 1.5 -0.3 0.8 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 1.7 -1.3 -0.3 -0.7 0.1 -0.4 0.6 0.8 0.7 -0.2 0.3 1.1 0.4 0.8
Relative age voice broke 1.0 1.6 4.2 -1.4 -1.4 -0.9 -0.2 -1.9 -0.7 -0.2 -0.3 -1.4 -2.1 -0.6 -2.0 -1.1
Taking other prescription medications 0.5 0.8 2.7 1.3 -0.1 0.4 -0.0 -0.6 -0.5 0.9 0.9 0.1 -1.6 -1.2 -1.0 -0.9
Age when periods started (menarche) 0.7 1.7 3.8 -0.2 -1.5 0.4 1.7 -1.9 0.3 0.8 1.1 -1.5 -1.3 -1.9 -1.1 -1.4
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.2 0.8 -1.0 -0.5 -0.4 -0.4 -0.1 0.3 0.4 -1.1 -0.2 -0.3 -0.4 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 3.6 -1.9 -0.0 -1.0 -0.7 0.5 1.1 -1.6 -1.5 -0.2 1.1 1.6 0.2 0.5
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.1 -0.0 -1.1 -0.9 -0.6 -0.5 0.1 -0.8 -0.8 -1.0 -0.3 0.3 -0.5 -0.1
Qualifications: CSEs or equivalent 1.3 1.8 5.2 0.4 -0.5 -1.4 0.1 1.2 -0.8 -2.3 -2.3 -0.4 1.5 2.2 -0.1 0.9
Serious illness, injury or assault to yourself 0.5 0.7 2.7 1.6 -0.5 -0.4 -0.1 -0.8 -0.7 0.5 0.5 -0.5 -1.2 -1.0 -0.7 -0.6
High blood pressure 0.4 1.0 3.2 0.6 -1.1 -1.8 1.1 -1.2 0.4 -0.6 -0.4 -0.9 -1.1 0.8 -1.4 0.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.7 -0.4 0.7 1.0 -0.3 1.0 0.6 -0.1 0.1 0.7 1.6 -0.6 0.9 0.8
Multivitamins +/- minerals 0.2 0.3 1.1 0.2 -0.3 -0.3 -0.8 -0.0 -0.5 -0.9 -1.0 -0.3 0.4 0.7 -0.3 -0.1
Stomach or abdominal pain in last month 1.1 1.3 4.6 0.3 -1.2 -0.1 0.2 -1.6 -0.8 0.5 0.7 -1.1 -1.3 -2.1 -1.4 -1.6
Supplements: Glucosamine 0.7 0.9 2.4 0.1 1.2 0.5 0.7 0.9 0.2 -0.4 -0.4 1.2 1.1 0.8 1.5 1.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.4 -1.2 0.5 0.5 1.0 0.3 -0.6 0.7 0.7 0.5 -0.1 -0.1 0.0 1.1
Medication: Atenolol 1.0 1.3 3.8 -1.9 -1.4 -1.2 0.6 -1.3 -0.9 0.3 0.3 -1.4 -0.7 -0.9 -0.7 -1.6
Medication: Levothyroxine sodium 0.2 0.3 1.4 0.3 -1.2 -0.0 0.3 -0.4 -0.3 0.2 0.1 -1.0 -0.5 0.2 -0.6 0.1
Sitting height 1.0 7.3 18.1 -3.5 2.9 0.8 -0.4 3.4 3.0 -0.9 -1.2 2.7 4.3 3.0 3.0 2.8
Chronic bronchitis/emphysema (father) 0.2 0.2 0.9 -0.2 -0.3 0.1 0.3 -0.4 -0.9 -0.3 -0.1 -0.1 -0.9 -0.1 -0.5 -0.2
High blood pressure (mother) 0.9 1.2 4.1 0.2 -0.9 -1.3 0.3 -0.5 -0.5 -1.9 -2.0 -1.0 -1.2 1.1 -1.2 -0.4
Body mass index (BMI) 0.2 0.9 4.0 0.5 -0.4 -1.7 0.7 0.1 -0.3 -1.1 -0.9 -0.4 0.7 2.0 0.1 1.2
Impedance of leg (left) 0.4 1.8 11.6 -0.5 -1.0 -0.1 -1.2 -0.9 -0.4 -0.2 -0.2 -1.1 -1.0 -3.4 -1.2 -2.2
Leg predicted mass (left) 0.5 2.8 13.7 -1.0 1.5 0.4 0.5 1.5 1.9 0.2 0.1 1.5 1.8 3.7 1.2 2.5
Trunk fat mass 0.1 0.3 1.1 -0.4 -0.0 -0.7 0.7 0.3 1.0 0.3 0.5 0.1 0.6 0.5 -0.3 0.3
Waist circumference 0.1 0.5 2.2 0.3 0.2 -0.5 1.5 0.3 1.1 0.3 0.4 0.3 1.0 0.6 0.0 0.8
Number of incorrect matches in round 0.2 0.3 1.1 1.0 0.2 -0.4 1.1 0.1 -0.6 0.4 0.4 0.4 -0.2 0.5 0.9 -0.1
Past tobacco smoking 1.2 2.2 5.8 -0.4 -1.7 -1.7 -1.3 -2.0 0.4 -1.3 -1.2 -1.6 -0.8 -0.7 -2.0 -2.4
Alcohol usually taken with meals 0.9 1.4 5.9 0.6 0.2 -1.6 0.7 -0.0 -0.2 -2.4 -2.4 -0.1 0.1 1.8 0.4 0.3
Nervous feelings 1.2 2.2 6.7 -2.0 -1.1 0.4 0.2 -1.5 -0.9 0.5 1.0 -1.0 -2.1 -2.6 -1.9 -1.5
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.9 -0.2 0.5 0.9 0.5 0.4 1.7 1.5 1.5 0.7 0.5 0.1 0.1 -0.2
Hearing difficulty/problems with background noise 0.7 1.1 2.8 1.0 -1.7 -1.5 -0.7 -0.9 0.4 0.5 0.6 -1.6 -0.3 -0.5 -1.4 -1.1
Hair/balding pattern: Pattern 2 0.5 0.7 4.2 -0.1 0.5 0.4 -2.1 -0.3 0.3 0.4 0.2 0.6 0.2 -1.6 -0.3 -0.8
Had menopause 0.5 0.6 4.4 0.9 -0.5 0.0 2.1 0.3 0.4 0.6 0.7 -0.4 0.8 0.3 -0.1 -0.9
Had other major operations 1.3 1.6 4.8 0.0 1.7 1.1 -0.2 1.8 0.5 0.8 0.4 1.7 1.1 1.2 1.5 2.2
Forced vital capacity (FVC) 0.4 1.7 8.1 -2.8 -0.1 -0.6 1.1 -0.0 0.6 -2.0 -2.1 -0.3 -0.3 1.3 -0.5 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 4.2 -2.1 0.5 -0.4 -0.1 0.8 1.1 -0.8 -0.8 0.3 1.3 1.5 0.5 0.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.6 0.7 -0.3 -0.6 -0.6 -0.6 0.0 1.3 1.2 -0.2 -1.1 0.6 -1.2 0.0
Qualifications: None of the above 0.8 1.7 5.5 -0.2 -0.2 1.4 2.3 -0.2 0.9 1.8 2.1 -0.3 -1.2 -1.6 -1.2 -0.7
Financial difficulties in last 2 years 0.2 0.2 0.7 0.6 -0.6 -0.7 -0.7 -0.2 -0.5 0.4 0.3 -0.3 0.0 -0.0 -0.8 -0.1
Mouth/teeth dental problems 0.6 0.9 4.9 -0.0 -0.5 -1.3 -2.2 -0.5 -1.1 -1.1 -1.2 -0.6 -0.1 0.0 -0.4 0.4
Heart attack 0.6 0.8 2.8 1.0 -0.2 0.2 1.4 -0.6 -0.1 1.5 1.7 -0.2 -0.2 -1.4 0.0 -0.3
Allergy 0.1 0.2 0.6 -0.6 -0.4 -0.8 0.6 -0.3 0.1 -0.2 -0.2 -0.4 -0.6 0.7 -0.2 -0.3
Pain all over the body in last month 0.2 0.2 1.7 -0.1 -0.2 -0.3 0.5 -0.6 0.2 0.0 -0.2 -0.2 0.1 0.2 -0.1 1.3
Diabetes (self-reported) 0.5 0.7 1.8 0.8 0.7 1.3 -0.3 -0.0 0.8 1.1 1.1 0.7 -1.0 -1.3 0.2 0.4
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 3.2 1.1 1.0 1.4 0.4 1.8 1.7 0.6 0.8 1.0 1.5 -0.0 1.2 0.5
Medication: Ramipril 1.1 1.4 3.8 -0.2 -1.1 0.3 0.9 -1.5 -1.2 1.1 1.3 -1.2 -1.6 -1.0 -1.9 -0.7
Medication: Simvastatin 1.0 1.5 4.7 0.7 1.5 2.2 0.3 0.6 1.1 1.5 1.5 1.4 0.0 -1.8 0.6 -0.1
Fluid intelligence score 1.5 3.1 8.7 -1.6 3.0 2.6 -0.9 1.3 1.1 0.9 0.7 2.8 1.1 0.0 2.6 1.2
Illnesses of siblings 0.9 1.2 7.5 0.9 1.0 0.8 -2.7 0.7 2.0 0.2 -0.2 0.9 0.5 -0.4 -0.1 0.3
Neuroticism score 0.3 0.5 2.4 -0.9 0.2 0.3 0.9 0.3 0.7 1.4 1.6 0.3 0.2 -0.5 -0.3 -0.1
Weight 0.3 1.4 7.1 -0.5 0.8 -0.5 0.6 1.0 1.2 -0.2 -0.2 0.8 1.5 2.7 0.8 1.9
Impedance of arm (right) 0.7 3.1 13.7 -1.4 0.5 1.7 -1.1 0.1 1.8 2.6 2.6 0.7 -0.3 -3.7 -1.0 -1.4
Arm fat percentage (right) 0.1 0.2 1.5 0.1 -0.2 -1.2 0.4 0.2 0.4 -0.1 0.3 -0.0 0.8 0.1 -0.1 0.5
Trunk fat-free mass 0.4 2.3 13.3 -0.0 1.4 0.4 -0.1 1.2 1.2 -0.0 -0.2 1.2 1.4 3.6 1.4 2.3
Hip circumference 0.2 0.7 2.8 -0.6 -0.3 -1.2 1.4 -0.4 0.6 -0.6 -0.6 -0.3 0.8 1.7 -0.1 0.6
Time employed in main current job 0.5 0.6 1.5 0.6 -0.1 -1.2 -1.1 -0.1 0.8 -1.2 -1.1 -0.1 0.7 -0.2 0.8 0.1
Alcohol intake versus 10 years previously 1.2 1.7 4.4 0.4 -0.7 -0.4 -1.1 -2.1 -1.2 0.8 0.6 -0.7 -2.0 -1.4 -1.9 -1.9
Father’s age at death 0.5 0.6 2.1 -0.2 1.1 0.4 -0.3 1.1 1.4 0.2 0.1 1.3 0.7 0.8 0.5 0.4
Worrier / anxious feelings 0.4 0.8 2.7 -1.6 -0.3 -0.4 0.4 -1.0 1.7 0.8 0.9 -0.3 0.0 -0.8 -0.6 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 3.1 0.4 0.6 0.5 0.1 0.4 0.6 1.7 1.8 0.8 -0.1 0.7 0.1 1.0
Falls in the last year 0.3 0.4 1.0 -0.8 -0.7 0.0 0.0 -0.2 1.0 0.9 0.8 -0.5 -0.7 0.2 -0.9 -0.0
Hair/balding pattern: Pattern 3 0.9 1.4 3.4 0.2 1.3 1.5 1.5 1.8 1.3 0.4 0.5 1.3 1.1 1.1 1.4 0.5
Number of live births 0.5 0.7 4.5 -0.2 -0.1 -0.2 1.2 0.8 0.8 0.6 0.5 -0.1 2.1 0.7 0.7 -0.2
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 3.4 -1.9 0.5 -0.1 0.6 0.4 1.1 -1.4 -1.5 0.4 0.0 1.4 0.0 1.1
Pulse rate 0.5 0.8 2.2 1.4 0.6 0.1 1.5 0.9 0.8 -0.3 -0.4 0.6 0.9 0.8 1.1 0.9
Happiness 0.8 0.9 3.8 -1.0 0.2 1.2 0.9 -0.5 0.4 2.0 1.9 0.3 -0.9 -0.4 0.1 0.1
Noisy workplace 0.1 0.2 0.6 0.3 -0.8 -0.7 0.3 -0.3 0.1 -0.6 -0.3 -0.7 -0.1 -0.2 -0.1 0.0
Qualifications: A levels/AS levels or equivalent 0.4 1.0 2.2 0.1 1.5 0.6 -1.1 1.0 0.8 -0.4 -0.7 1.4 0.7 1.0 1.2 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 7.0 -0.6 -0.4 0.1 -2.6 0.2 -1.1 -0.1 -0.3 -0.2 1.0 -0.4 0.2 -0.0
Mouth/teeth dental problems: Dentures 0.8 1.3 3.7 0.6 -0.3 1.0 1.9 -0.7 -0.1 1.7 1.8 -0.2 -0.5 -1.9 0.0 -1.4
Asthma 0.5 0.9 2.8 1.7 -0.4 -0.5 -0.8 -0.7 -0.9 -1.0 -1.1 -0.3 -1.6 0.4 -1.4 -0.2
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.6 5.2 -2.3 -1.3 -2.2 -0.1 -2.2 -1.2 -1.6 -1.9 -1.3 -1.9 0.6 -1.9 -0.5
Medication: Cholesterol lowering 0.9 1.5 4.0 1.1 1.2 1.8 -0.1 1.0 0.6 1.8 2.0 1.2 0.4 -1.0 1.3 0.1
Depression (self-reported) 0.9 1.1 2.2 0.2 1.4 1.0 -0.1 1.1 0.9 0.9 0.8 1.5 1.2 0.5 1.4 1.2
Medication: Lansoprazole 1.5 1.7 4.9 -0.3 -0.1 1.4 -0.5 -1.6 1.1 1.8 1.9 -0.2 -2.0 -2.2 -0.4 -0.7
Prospective memory result 0.4 0.5 1.2 0.7 0.7 0.1 0.9 1.1 1.0 0.3 -0.1 0.8 0.4 0.9 0.5 0.3
Lung cancer (father) 2.3 2.6 7.3 -1.1 -2.2 -2.7 1.2 -0.9 -1.5 -1.9 -2.0 -2.3 -0.5 1.0 -1.3 -0.5
Illnesses of mother 0.4 0.4 1.9 -1.4 -0.1 -0.0 -1.1 0.0 -0.5 -0.4 -0.3 -0.1 1.0 -0.6 0.8 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 5.9 -2.4 0.1 -0.6 0.2 0.0 0.9 -1.3 -1.5 0.1 -0.0 1.5 -0.1 0.6
Pulse wave Arterial Stiffness index 0.8 0.9 3.2 1.8 -1.4 0.2 0.7 -1.3 -0.9 0.2 -0.1 -1.4 -0.8 -0.5 -0.7 -0.9
Impedance of arm (left) 0.6 2.8 14.0 -1.9 0.1 1.5 -0.4 0.0 1.8 2.2 2.2 0.4 -0.4 -3.7 -0.9 -1.4
Arm fat mass (right) 0.1 0.5 1.7 -0.3 0.0 -1.2 0.5 0.4 0.7 -0.4 -0.1 0.2 1.1 1.3 0.4 1.2
Trunk predicted mass 0.4 2.2 13.3 -0.0 1.4 0.4 -0.1 1.2 1.1 -0.1 -0.2 1.2 1.4 3.6 1.5 2.3
Standing height 0.4 4.3 10.7 -2.2 2.6 2.4 -0.3 2.0 3.3 1.9 1.6 2.5 1.7 1.7 1.6 1.8
Length of working week for main job 0.6 0.6 1.9 -0.8 0.7 -0.5 -0.6 0.5 0.5 -1.4 -1.4 0.5 1.0 0.7 0.5 0.4
Exposure to tobacco smoke at home 0.7 0.8 2.6 -0.3 -0.4 0.2 -0.3 -0.8 -0.2 1.0 1.0 -0.4 -1.6 -1.1 -1.4 -1.2
Breastfed as a baby 0.4 0.5 1.3 -0.0 0.7 0.2 -0.5 1.1 1.0 0.9 0.9 0.8 0.5 0.1 0.7 0.2
Tense / ‘highly strung’ 0.2 0.3 1.7 -0.5 1.0 0.1 -0.1 0.7 1.3 0.0 -0.1 1.0 -0.0 0.2 -0.2 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.8 -0.6 -0.4 -0.3 -0.4 -0.3 0.1 0.3 0.4 -0.4 -0.6 0.1 -0.9 -0.3
Hair/balding pattern: Pattern 4 2.4 5.8 11.3 1.7 3.4 2.9 1.3 2.6 2.3 2.1 2.5 3.3 1.5 -0.7 3.1 2.2
Birth weight of first child 0.4 0.7 3.1 -0.2 -0.6 -0.5 -0.5 -1.0 0.1 -0.3 -0.3 -0.6 -1.0 -0.5 -1.3 -1.8
Peak expiratory flow (PEF) 0.2 0.4 1.2 0.2 0.4 0.2 -0.7 0.4 -0.4 -1.1 -1.1 0.4 0.3 0.6 0.3 0.7
Pulse wave reflection index 3.0 3.7 8.9 -0.5 -2.7 -1.3 -0.4 -3.0 -1.7 -1.1 -1.2 -2.8 -2.2 -2.3 -1.7 -1.6
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.9 0.1 -0.3 -0.7 -0.9 -0.4 0.9 0.3 0.1 -0.2 -0.1 0.8 -0.9 -0.3
Loud music exposure frequency 0.6 0.6 1.8 -1.1 0.5 0.2 -0.4 0.8 1.1 -0.4 -0.7 0.4 0.7 1.1 -0.0 1.3
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.6 -0.0 0.3 0.9 1.2 0.6 1.1 0.1 0.1 0.3 0.3 0.7 0.6 0.7
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 6.7 -1.4 -0.8 -1.2 2.6 0.3 -0.1 -1.4 -1.4 -0.8 0.2 2.6 -0.1 0.6
Blood clot in the leg (DVT) 1.0 1.3 4.5 1.1 1.1 1.2 0.7 0.6 0.4 1.6 1.6 1.2 0.8 -0.2 2.1 0.3
Medication: Paracetamol 0.1 0.2 0.5 -0.3 -0.2 -0.5 -0.1 -0.5 0.5 0.7 0.6 -0.1 0.2 0.2 0.4 0.1
Headache pain in last month 0.5 0.9 2.5 -1.4 -0.7 0.4 0.5 -1.3 -0.4 0.7 0.9 -0.6 -1.0 -1.6 -0.7 -1.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.3 -0.3 0.5 0.2 0.3 0.9 0.7 -0.6 -0.8 0.4 1.5 0.4 0.8 0.5
Glaucoma (self-reported) 0.7 0.9 2.2 0.5 -1.0 -0.2 1.2 -1.5 -0.9 0.7 0.5 -0.9 -1.5 -0.1 -0.8 -1.0
Gout (self-reported) 0.9 1.2 8.2 1.0 -0.9 -1.3 -2.9 -0.8 -0.6 -0.4 -0.3 -0.8 -1.4 -0.3 -0.8 -0.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.4 -0.1 -0.6 0.1 0.4 -0.1 -0.6 0.2 0.1 -0.4 -0.1 0.3 -0.1 -0.3
Medication: Amlodipine 0.6 0.9 6.4 -0.6 0.2 0.5 2.5 -0.6 1.3 -0.1 -0.0 0.2 -1.3 -0.2 -0.8 0.3
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.6 -0.0 -0.1 0.1 -0.3 -0.2 -0.7 -0.0 0.0 -0.3 -0.3 0.1 -0.4 0.6
Birth weight 0.5 1.0 4.0 -1.6 0.7 1.3 -2.0 0.8 0.6 0.9 1.0 0.7 0.4 -0.7 -0.2 -0.6
Chronic bronchitis/emphysema (mother) 0.7 0.8 3.8 0.6 -0.5 0.5 1.9 -0.5 -0.1 1.4 1.4 -0.5 0.4 -0.8 0.1 0.6
High blood pressure (siblings) 0.8 1.1 4.8 -1.4 -1.0 -0.8 2.2 -1.1 -1.3 -0.3 0.1 -0.9 -1.0 1.0 -0.2 -0.3
Forced vital capacity (FVC), Best measure 0.5 1.9 11.8 -3.4 -0.5 -1.1 0.8 -0.5 0.5 -1.8 -2.0 -0.6 -0.6 1.3 -0.7 0.2
Body fat percentage 0.1 0.3 1.3 0.0 -0.6 -1.2 0.8 -0.1 0.4 0.1 0.4 -0.4 0.4 -0.4 -0.7 -0.3
Leg fat percentage (right) 0.2 0.6 3.9 -0.3 -0.7 -2.0 0.5 0.1 -0.2 -1.0 -0.7 -0.6 1.0 0.8 -0.0 0.4
Arm fat-free mass (right) 0.4 1.9 13.0 0.0 0.7 -0.2 0.4 0.9 0.8 -1.0 -1.1 0.6 1.2 3.6 1.1 1.9
Exposure to tobacco smoke outside home 0.6 0.8 2.3 0.7 -0.9 -0.9 0.8 -0.9 -0.3 -1.1 -1.0 -1.0 -1.1 0.3 -1.5 -0.4
Comparative body size at age 10 0.4 1.2 2.9 -1.1 -0.7 -1.4 -1.7 -0.1 0.2 -1.6 -1.5 -0.7 0.8 1.5 0.3 0.5
Number of full brothers 0.6 0.7 2.5 -1.6 -0.4 0.6 1.3 -0.0 0.6 1.5 1.1 -0.4 0.8 -0.2 -0.5 0.2
Worry too long after embarrassment 0.3 0.5 1.6 -0.3 0.7 0.9 0.7 0.3 1.1 1.2 1.1 0.6 -0.1 -0.3 -0.1 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 4.5 -0.4 2.0 0.9 0.2 1.8 0.9 1.1 0.9 2.1 1.6 1.1 1.4 1.6
Wheeze or whistling in the chest in last year 0.6 1.1 2.6 0.9 -1.4 -1.3 0.3 -0.9 -1.6 -1.5 -1.2 -1.5 -0.4 -0.1 -0.7 -0.2
Number of children fathered 0.6 0.7 1.8 1.3 0.0 1.1 0.4 -0.0 -0.8 1.2 1.2 0.0 -0.7 -1.3 0.5 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.4 -0.1 0.2 -0.2 -1.0 0.4 -0.7 -0.3 -0.5 0.1 0.7 0.8 -0.1 1.2
Age at first live birth 2.4 4.2 9.8 0.3 3.1 2.1 -0.4 1.9 2.1 1.1 1.1 3.0 2.0 1.2 3.1 2.3
Pulse wave peak to peak time 1.2 1.4 4.0 -2.0 1.7 0.1 -0.8 1.6 1.3 0.1 0.4 1.7 1.0 0.7 0.9 1.1
Health satisfaction 0.7 0.9 4.5 0.3 -1.4 -2.1 0.2 -1.5 -0.2 -0.5 -0.7 -1.3 -0.4 0.7 -0.3 -0.4
Shortness of breath walking on level ground 0.7 0.9 4.3 0.4 -0.8 -1.9 0.0 0.0 -0.6 -0.8 -0.9 -0.7 0.1 2.1 -0.0 0.5
Qualifications: College or University degree 1.7 5.2 12.2 -1.2 2.9 0.3 -0.7 2.6 2.4 -0.4 -0.7 2.8 3.0 3.1 3.5 2.4
Eye problems/disorders: None of the above 0.1 0.1 0.5 0.7 0.2 0.7 -0.3 0.1 -0.2 0.2 0.4 -0.0 0.3 0.1 -0.0 0.2
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.9 0.9 0.6 1.1 -0.1 0.2 1.6 2.0 1.8 0.7 -0.7 0.3 -0.7 -0.6
Emphysema/chronic bronchitis 0.7 0.8 3.9 -0.0 -0.8 -0.1 0.5 -0.8 -1.4 0.2 0.6 -0.9 -0.8 -2.0 -0.8 -0.7
Medication for pain relief, constipation, heartburn 0.9 1.6 5.6 0.6 1.4 1.6 -0.1 2.4 0.8 0.7 0.6 1.4 1.4 0.6 1.5 1.4
Neck or shoulder pain in last month 1.9 2.7 7.4 1.5 -0.0 1.3 0.4 -1.1 -0.6 2.6 2.7 0.1 -2.0 -2.4 -1.2 -1.9
Medication: Blood pressure 0.3 0.5 1.5 -0.9 -0.5 -0.3 0.3 -1.0 -0.4 0.7 1.1 -0.3 -1.2 -0.0 -0.6 0.1
Angina (self-reported) 0.7 0.9 3.0 1.1 -0.9 -0.4 -0.6 -1.3 -0.9 0.1 -0.1 -0.8 -1.0 -1.3 -1.7 -0.9
Migraine (self-reported) 0.4 0.5 4.5 -0.7 0.4 -0.4 -0.3 0.5 -0.5 -0.0 -0.3 0.2 0.2 2.1 -0.4 0.3
Medication: Ibuprofen 1.9 2.2 4.2 -2.0 -1.1 -2.0 -0.3 -1.8 -0.9 -1.6 -1.9 -1.1 -1.6 1.2 -1.9 -0.4
Medication: Allopurinol 0.7 0.9 4.4 1.0 -1.1 -1.5 -2.1 -0.9 -0.4 -0.3 -0.2 -1.0 -0.4 -0.3 -0.2 -0.2
Medication: Omeprazole 1.6 1.9 4.7 -0.8 -1.3 -0.8 0.1 -2.2 -1.0 -1.0 -1.0 -1.3 -1.8 -1.8 -1.6 -1.7
Medication: Seretide 50 evohaler 0.4 0.5 1.7 0.7 0.1 0.7 0.6 0.6 0.4 1.3 1.2 0.1 0.3 0.6 0.0 0.6
Mean time to correctly identify matches 0.2 0.3 1.0 0.6 -0.1 0.6 1.0 0.7 0.7 0.2 0.6 -0.1 0.9 -0.1 0.5 0.2
Heart disease (mother) 0.1 0.2 0.9 -0.2 -0.2 -0.3 0.2 0.3 -0.3 0.1 0.3 -0.1 0.1 -0.5 -1.0 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 2.2 1.5 -0.3 0.1 -0.5 -0.4 0.2 -0.5 -0.4 -0.1 -0.3 -1.1 0.1 -0.6
Whole body fat mass 0.1 0.4 0.9 -0.2 -0.0 -0.9 0.9 0.4 0.8 0.0 0.3 0.1 0.9 1.0 0.1 0.6
Leg fat mass (right) 0.3 1.0 4.2 -0.4 -0.1 -1.5 0.6 0.6 0.6 -0.9 -0.7 -0.1 1.4 2.1 0.5 1.3
Arm predicted mass (right) 0.4 2.1 14.8 -0.1 1.0 -0.1 0.5 1.1 0.9 -0.7 -0.9 0.8 1.3 3.8 1.1 2.1
Pulse rate, automated reading 0.2 0.7 2.0 1.4 0.7 0.8 1.0 0.4 0.8 0.9 1.2 0.8 -0.2 -0.9 0.4 0.0
Alcohol intake frequency. 1.2 2.7 6.1 2.4 -2.1 -1.9 0.1 -2.5 -0.5 -0.3 -0.3 -1.9 -1.9 -0.8 -1.9 -2.0
Comparative height size at age 10 0.1 0.7 1.8 -0.6 0.5 1.3 -1.0 0.2 1.2 1.3 1.3 0.5 -0.2 0.8 -0.2 0.1
Number of full sisters 0.9 1.1 2.5 -0.6 -0.7 -0.1 -0.4 -1.2 -1.5 1.3 1.2 -0.7 -1.0 -0.6 -1.6 -1.4
Suffer from ‘nerves’ 0.7 1.1 3.6 -1.0 -0.9 0.0 -0.1 -1.6 -0.5 -0.1 -0.1 -0.8 -1.6 -1.1 -1.9 -1.3
Overall health rating 1.7 3.6 9.1 0.9 -2.5 -1.6 1.6 -2.7 -1.2 0.6 0.9 -2.4 -2.7 -0.3 -3.0 -1.5
Chest pain or discomfort 0.6 0.8 2.8 0.4 -1.7 -1.4 0.0 -0.6 -0.8 -0.8 -0.6 -1.6 -0.2 -0.1 -1.0 0.2
Had major operations 0.3 0.4 1.6 1.0 0.4 0.4 0.3 0.6 -0.1 -1.3 -0.8 0.5 0.2 0.1 -0.4 0.3
Age at last live birth 1.8 2.6 7.5 0.3 2.0 2.7 0.7 0.6 0.8 2.7 2.7 2.0 0.4 -0.3 1.3 0.8
Family relationship satisfaction 0.2 0.2 0.9 -0.2 -0.4 -0.6 -0.1 -0.8 -0.8 -0.3 -0.2 -0.2 -1.0 0.3 0.0 -0.2
Leg pain on walking 0.7 0.8 2.5 -0.9 -0.9 -1.3 1.6 -0.8 0.8 -1.2 -1.0 -0.7 -1.0 0.3 -0.4 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.5 -1.2 0.2 0.5 -0.0 0.6 -0.5 0.7 0.5 0.2 0.5 -0.0 0.3 -0.0
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.2 0.9 -0.0 0.6 -0.7 0.3 -1.0 0.1 0.3 -0.2 0.3 -1.1 0.3 -0.1
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.9 -1.3 1.7 1.4 1.0 0.8 1.0 0.8 0.8 1.4 -0.3 -0.0 1.2 0.2
Medication: Aspirin 0.1 0.1 1.1 1.0 0.2 0.0 0.4 0.3 -0.1 0.2 0.2 0.3 0.3 0.4 0.1 -0.1
Supplements: Vitamin C 2.1 2.4 5.2 1.3 -2.0 -0.1 -0.6 -2.3 -1.7 -0.0 0.3 -2.0 -1.7 -1.9 -1.6 -2.1
Knee pain experienced in last month 0.4 0.6 2.5 -1.6 -0.8 -1.1 0.1 -0.3 1.1 -0.8 -0.5 -0.7 0.5 0.3 0.0 -0.0
Hypertension (Self-reported) 0.4 1.0 3.0 0.8 -1.1 -1.4 1.2 -1.4 0.5 0.1 0.3 -0.9 -1.4 0.4 -1.7 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.9 4.6 11.9 0.3 -2.4 -1.0 -1.4 -2.8 -1.1 -0.1 0.3 -2.3 -3.4 -2.7 -2.9 -2.9
Illnesses of father: Heart disease 0.9 1.3 3.5 0.2 0.7 -0.5 1.4 0.6 0.8 -0.7 -1.0 0.8 1.5 1.9 1.4 1.8
Illnesses of siblings: Diabetes 0.4 0.5 1.9 0.7 0.5 0.5 0.5 0.7 -0.7 -0.2 0.1 0.6 0.2 -0.1 1.2 1.4
Smoking status: Previous 0.9 1.4 3.2 0.2 0.9 1.4 1.8 1.6 -0.5 1.2 1.4 0.9 0.5 -0.2 1.5 1.6
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 7.6 -2.8 1.2 0.0 -1.2 0.9 2.1 0.2 -0.1 1.3 1.5 1.3 1.3 1.9
Whole body fat-free mass 0.4 2.4 13.9 -0.5 1.4 0.3 0.2 1.3 1.5 -0.1 -0.2 1.3 1.5 3.7 1.4 2.4
Leg fat-free mass (right) 0.4 2.1 10.3 -1.0 1.2 0.4 0.6 1.2 1.8 0.2 0.1 1.2 1.3 3.2 1.0 2.2
Arm fat percentage (left) 0.1 0.3 1.6 -0.1 -0.4 -1.3 0.7 0.3 0.5 -0.3 0.0 -0.1 0.7 0.2 -0.2 0.5
Average weekly red wine intake 0.8 1.2 3.7 0.0 1.3 0.7 -0.6 1.2 1.9 0.4 0.5 1.0 0.7 0.8 1.7 1.4
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.0 -0.8 0.2 -0.2 1.4 0.6 0.8 -0.8 -0.9 0.0 0.8 1.3 -0.2 0.3
Mood swings 0.6 1.2 3.1 0.5 0.8 1.1 0.6 1.5 -0.3 1.1 1.5 1.0 1.8 -0.7 1.4 0.6
Loneliness, isolation 0.7 1.0 3.1 -0.1 -0.5 0.4 1.2 0.4 0.3 1.8 1.7 -0.5 1.2 1.0 0.3 1.4
Long-standing illness, disability or infirmity 1.5 2.3 5.3 1.4 -2.3 -2.0 -0.4 -2.1 -1.7 -0.6 -0.8 -2.1 -1.5 -0.5 -1.6 -1.0
Ever had bowel cancer screening 3.5 4.1 12.8 2.0 -1.9 -0.3 0.5 -2.0 -3.1 0.1 0.5 -2.0 -1.2 -3.6 -2.4 -2.9
Diabetes diagnosed by doctor 0.7 1.1 5.8 -0.5 -0.1 0.9 -0.5 -1.1 -0.2 1.1 1.1 0.0 -1.8 -2.4 -0.5 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 0.6 -0.1 0.4 0.2 -0.8 -0.5 0.4 -0.5 -0.7 0.7 -0.2 0.7 -0.3 0.6
Friendships satisfaction 0.4 0.6 2.4 1.6 -0.1 0.5 0.5 -0.3 -0.4 0.9 1.2 0.0 -1.3 -0.0 -0.2 -0.2
Qualifications: nursing, teaching 0.8 1.2 8.5 0.4 1.2 -0.1 -2.9 0.3 1.0 -1.0 -1.0 1.2 0.2 0.6 0.6 0.3
Commuting to job workplace: Walk 1.5 1.6 4.1 -1.1 -1.6 -1.2 0.0 -1.9 0.1 -0.3 -0.6 -1.6 -1.5 -1.1 -2.0 -1.3
Eye problems/disorders: Cataract 0.4 0.5 2.5 -0.3 0.2 -0.3 -1.4 -0.0 -0.5 0.1 0.1 0.3 -0.5 -1.6 -0.2 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 4.0 1.1 1.2 2.0 -0.7 0.3 1.1 1.2 1.2 1.2 -0.3 -1.3 0.8 -0.1
Medication for cholesterol 0.2 0.4 1.8 -1.3 0.6 0.7 -0.9 0.7 0.0 0.1 0.0 0.6 0.1 -0.5 0.5 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.4 0.7 -0.0 0.3 0.0 -0.2 0.4 1.1 1.2 0.1 0.7 0.1 0.8 0.4
Back pain experienced in last month 0.4 0.6 2.0 -0.0 -1.4 -1.0 0.1 -0.7 -1.3 -1.0 -0.9 -1.2 -0.3 -0.1 0.1 0.6
Mineral and other dietary supplements 0.1 0.1 0.4 -0.2 -0.2 -0.6 0.3 -0.1 0.5 0.1 0.0 -0.3 -0.6 0.6 -0.3 0.0
Breast cancer (self-reported) 0.2 0.3 1.0 -0.0 0.0 -0.3 0.3 -1.0 -0.2 0.8 0.8 0.2 -1.0 -0.0 -0.2 -0.6
Asthma (self-reported) 0.5 1.0 2.8 1.4 -0.5 -0.6 -1.0 -0.8 -0.9 -1.2 -1.3 -0.3 -1.7 0.2 -1.4 -0.3
Osteoporosis (self-reported) 1.1 1.4 4.2 2.1 0.9 1.8 0.4 0.3 1.9 1.5 1.4 0.9 -0.6 -0.4 0.1 -0.2
Osteoarthritis (self-reported) 2.0 2.6 7.5 0.5 -1.4 -0.3 -1.5 -2.6 -1.5 0.7 0.9 -1.3 -2.4 -2.7 -1.1 -1.5
Medication: Aspirin 0.1 0.2 1.3 1.2 0.0 -0.0 0.4 0.2 -0.4 0.1 0.1 0.1 0.1 0.5 -0.3 -0.2
Medication: Gliclazide 0.3 0.3 2.7 -0.6 -0.2 -0.7 -1.6 -0.1 0.3 -0.4 -0.6 0.0 -0.4 -0.4 0.2 0.2
Illnesses of father: None of the above (group 1) 0.4 0.5 1.3 0.2 0.7 0.5 -0.7 1.1 0.8 0.8 0.8 0.5 0.7 -0.3 0.9 0.5
Smoking status: Current 0.3 0.5 3.6 0.8 -0.1 -0.1 -1.9 -0.5 -0.5 -0.2 -0.7 0.1 -1.1 0.0 -0.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 3.8 -1.5 -1.2 -1.4 0.7 -0.7 0.4 -1.9 -1.9 -1.2 -0.7 0.2 -0.8 -0.5
Whole body water mass 0.4 2.4 13.3 -0.5 1.4 0.4 0.3 1.3 1.4 -0.1 -0.2 1.3 1.5 3.7 1.4 2.4
Leg predicted mass (right) 0.4 2.1 10.3 -1.0 1.3 0.5 0.6 1.3 1.7 0.3 0.2 1.3 1.4 3.2 1.0 2.2
Arm fat mass (left) 0.1 0.5 1.6 -0.2 0.1 -1.1 0.6 0.5 0.7 -0.4 -0.2 0.2 1.0 1.3 0.3 1.1
Number of self-reported non-cancer illnesses 0.7 1.1 3.5 1.5 0.9 1.0 0.4 0.1 1.2 1.8 1.9 1.2 -0.7 0.5 0.2 0.4
Average weekly champagne plus white wine intake 1.0 1.3 4.2 -0.8 1.6 0.7 -0.2 1.6 2.0 0.2 -0.2 1.4 1.4 1.1 0.9 0.8
Miserableness 1.5 2.6 5.5 -1.2 1.7 1.5 0.7 2.0 0.4 1.7 2.0 1.9 2.4 0.4 2.1 1.4
Guilty feelings 0.1 0.1 0.5 -0.2 0.1 -0.2 -0.5 -0.1 0.7 0.4 0.4 0.1 0.3 -0.6 0.2 -0.4
Wears glasses or contact lenses 1.1 1.3 3.5 0.2 1.9 1.5 0.3 1.5 1.3 0.7 0.7 1.6 1.5 0.8 0.8 0.7
Ever taken oral contraceptive pill 1.9 2.1 4.5 -0.9 1.9 0.9 0.4 1.7 1.4 0.7 0.5 2.0 1.0 1.8 2.0 2.1
Hearing aid user 1.1 1.3 3.2 -0.2 1.7 1.5 1.3 0.8 1.0 1.5 1.5 1.8 -0.1 -0.2 0.2 -0.5
Mother’s age at death 1.5 1.9 4.6 1.8 1.5 1.4 -0.9 1.3 1.5 1.2 1.3 1.6 1.3 -0.4 2.1 -0.1
Financial situation satisfaction 0.4 0.4 2.0 -0.3 0.5 -0.1 1.2 0.4 1.4 0.6 0.4 0.6 0.2 0.3 0.5 0.7
Tinnitus: Yes, now most or all of the time 1.0 1.1 3.1 0.2 -0.7 0.6 1.8 -0.7 -1.7 1.2 1.7 -0.7 -0.4 -1.1 -0.6 -0.9
Commuting to job workplace: Public transport 0.3 0.4 0.9 -0.7 0.3 0.7 1.0 0.5 0.8 0.6 0.5 0.4 -0.1 0.9 -0.3 0.2
Eye problems/disorders: Glaucoma 1.0 1.2 6.1 0.6 -1.2 -1.0 2.5 -1.4 -0.7 -0.2 -0.1 -1.3 -0.7 0.3 -0.8 -1.0
Medication: Blood pressure 0.4 0.7 2.8 1.7 -0.0 -1.1 0.5 0.2 0.9 -0.6 -0.5 0.1 0.5 1.1 -0.5 1.2
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 -0.8 -0.8 -0.4 0.2 -0.9 0.5 0.4 0.4 -0.8 0.0 0.0 0.0 0.1
Supplements: Fish oil (including cod liver oil) 1.1 1.4 3.8 0.4 -1.3 -0.2 -0.3 -1.5 -1.9 -0.4 -0.2 -1.4 -0.8 -1.8 -1.5 -1.5
High cholesterol (Self-reported) 0.7 1.2 4.3 0.8 0.1 1.5 0.1 -0.9 -0.1 1.9 2.1 0.1 -1.1 -1.6 -0.4 -0.7
Medication: Bendroflumethiazide 1.1 1.7 3.7 -0.0 -1.9 -1.6 0.9 -1.0 -0.7 -1.9 -1.7 -1.8 -0.5 -0.6 -1.4 -0.9
Medication: Paracetamol 0.1 0.2 0.9 0.4 0.2 -0.9 -0.4 -0.2 0.5 0.3 0.1 0.3 0.5 0.7 0.4 0.5
Medication: Lisinopril 0.2 0.3 1.0 -0.4 -0.8 -1.0 -0.6 -0.8 -0.3 0.2 0.1 -0.7 -0.8 -0.3 -0.2 0.1
Medication: Atorvastatin 1.1 1.4 3.3 0.3 -1.8 -1.1 0.3 -1.6 -1.6 -0.6 -0.3 -1.8 -0.9 -0.1 -1.3 -1.5
Illnesses of father: High blood pressure 1.0 1.2 2.4 -1.4 -1.2 -1.6 1.3 -1.4 -1.0 -1.2 -1.0 -1.1 -1.1 0.1 -0.7 -0.6
Alcohol drinker status: Never 1.7 2.0 6.1 1.5 -1.5 -1.7 -0.4 -1.5 -0.0 -1.3 -1.6 -1.6 -1.2 0.4 -2.5 -1.2
Ever smoked 2.1 3.7 8.8 -0.3 2.4 2.0 1.2 2.7 1.0 1.4 1.1 2.3 1.5 1.9 2.4 3.0
Basal metabolic rate 0.4 2.2 12.5 -0.6 1.2 0.1 0.3 1.2 1.4 -0.2 -0.3 1.1 1.6 3.5 1.2 2.3
Leg fat percentage (left) 0.2 0.8 4.8 -0.2 -1.1 -2.2 0.7 -0.4 -0.6 -1.1 -0.8 -1.0 0.4 0.2 -0.5 -0.1
Arm fat-free mass (left) 0.3 1.4 10.5 0.1 0.7 -0.2 0.2 0.7 0.6 -0.7 -0.8 0.5 1.1 3.2 0.9 1.8
Number of operations (self-reported) 0.5 0.8 3.3 1.8 -0.4 -0.6 -1.5 -0.2 -0.6 -0.4 -0.5 -0.4 -0.8 -0.4 -1.2 -0.9
Average weekly beer plus cider intake 1.1 1.7 6.4 0.0 0.8 2.5 1.2 0.7 0.4 2.2 2.4 0.8 0.5 -0.9 -0.2 0.5
Irritability 0.9 1.4 5.0 0.1 -0.3 1.0 -0.9 -0.6 -0.4 1.8 1.8 -0.1 -1.5 -2.2 -1.2 -1.0
Risk taking 0.4 0.6 3.5 0.3 -0.0 -1.0 -0.4 0.3 -0.1 -0.8 -1.0 -0.0 0.8 1.9 0.4 0.8
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.5 1.2 0.6 0.3 0.3 1.6 0.7 0.5 0.6 0.7 1.2 0.8 0.8 0.3
Fractured/broken bones in last 5 years 0.8 1.0 4.4 -0.9 0.9 0.7 -0.5 0.7 0.4 -0.4 -0.4 1.1 2.1 -0.8 2.0 0.3
Age started oral contraceptive pill 0.4 0.5 1.7 0.4 0.4 0.9 0.5 -0.2 0.7 1.2 1.3 0.5 -0.3 -1.0 0.1 -0.1
Diastolic blood pressure, automated reading 0.2 0.8 2.5 0.0 -0.9 -1.3 1.6 -0.7 -0.3 -0.9 -0.3 -0.8 -1.1 0.2 -1.1 0.3
Ever depressed for a whole week 0.4 0.6 1.9 0.9 -0.5 -0.7 -0.7 -0.4 -0.8 -0.6 -0.7 -0.6 -0.9 0.8 -1.4 -0.2
Unable to work because of sickness or disability 0.6 0.8 3.8 -0.7 -0.8 -0.2 2.0 -0.9 1.4 0.4 0.5 -0.6 -0.8 0.6 -0.9 -0.0
Commuting to job workplace: Cycle 1.4 1.7 5.3 -1.4 0.4 -0.1 0.0 1.4 1.2 -1.0 -1.0 0.4 2.0 2.3 1.4 1.6
Myopia 4.0 5.8 14.7 0.9 2.6 3.8 -0.8 1.4 2.8 3.6 3.5 2.6 0.6 -2.3 1.9 0.9
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.3 -0.5 1.0 1.4 -1.5 0.9 -0.2 0.0 -0.2 0.8 0.7 -0.7 1.2 -0.7
Cholesterol lowering medication 0.5 0.8 3.7 0.7 -0.5 0.1 0.3 -1.2 -0.5 0.2 0.4 -0.5 -0.8 -1.9 -1.1 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.9 -1.0 -0.7 -0.3 0.2 -1.6 -1.1 -0.2 -0.1 -0.8 -1.3 -1.7 -1.1 -1.4
Pain experienced in last month 0.5 0.8 3.1 1.2 0.6 -0.7 -1.2 0.9 0.1 -0.8 -1.2 0.5 0.2 1.8 0.0 0.5
Supplements: Calcium 0.8 0.9 2.6 -0.7 0.6 0.1 1.3 0.5 1.2 0.7 0.6 0.7 1.5 1.1 1.6 0.6
Basal cell carcinoma (self-reported) 0.6 0.8 3.3 -0.3 -0.1 -0.5 -0.9 0.4 -1.0 -1.8 -1.8 -0.0 0.6 -0.8 -0.0 -0.5
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.7 0.5 -0.2 0.2 1.5 -0.6 -0.3 1.5 1.6 -0.2 0.0 -1.6 0.3 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 3.8 1.5 0.9 1.1 0.4 0.5 0.4 1.6 1.6 1.0 0.8 -0.5 2.0 0.1
Heart disease (siblings) 1.0 1.2 3.1 -0.5 -0.8 -1.8 1.0 0.3 -1.0 -1.4 -1.2 -0.6 1.6 1.2 1.1 -0.3
Alcohol drinker status: Previous 0.2 0.3 1.0 1.0 -0.6 -0.4 1.0 -0.1 -0.5 0.4 0.4 -0.7 -0.2 0.1 0.0 -0.3
Pack years of smoking 0.5 0.8 3.0 -0.4 0.5 1.1 1.6 0.7 0.5 1.5 1.7 0.5 0.0 0.0 -0.1 -0.2
Impedance of whole body 0.4 2.3 14.7 -1.2 -0.3 1.0 -1.0 -0.5 0.9 1.5 1.4 -0.2 -0.8 -3.8 -1.3 -2.0
Leg fat mass (left) 0.2 0.7 2.7 -0.2 -0.4 -1.7 0.6 0.2 0.4 -0.9 -0.7 -0.3 1.0 1.6 0.1 0.9
Arm predicted mass (left) 0.3 1.4 10.7 0.1 0.7 -0.3 0.0 0.6 0.4 -0.8 -0.9 0.5 1.1 3.3 0.8 1.8