Hub : Genes

FMNL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.263	0.0835	3.8e-04	0.143	NA	0.129	NA	0.156	8.0e-06	NA	2.3e-05	NA	3.1e-06
2	GTEx	Cells Transformed fibroblasts	0.092	0.0360	9.9e-04	0.065	NA	0.077	NA	0.067	1.3e-05	NA	2.1e-06	NA	9.6e-06
3	GTEx	Esophagus Mucosa	0.196	0.0730	9.7e-04	-0.004	NA	-0.002	NA	-0.004	7.7e-01	NA	4.6e-01	NA	8.3e-01
4	GTEx	Skin Not Sun Exposed Suprapubic	0.184	0.0680	4.8e-03	0.004	NA	-0.001	NA	0.008	1.8e-01	NA	3.8e-01	NA	1.0e-01
5	GTEx	Thyroid	0.121	0.0470	1.9e-03	-0.004	NA	0.047	NA	0.004	9.8e-01	NA	1.7e-04	NA	1.5e-01
6	TCGA	Thyroid Carcinoma	0.078	0.0280	3.7e-05	0.042	0.045	0.032	NA	0.044	5.5e-05	3.4e-05	4.2e-04	NA	3.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.7	0.5	0.5	1.3	-0.5	0.7	0.2
Bipolar Disorder or Schizophrenia	0.6	1.5	3.5	0.4	-0.0	1.8	-1.9	1.3	0.8
Depressed Affect (Nagel 2018)	0.4	0.8	1.5	0.6	0.6	-0.9	1.2	1.0	0.8
Depression (Nagel 2018)	0.5	0.7	2.9	-0.8	-0.1	-0.3	-0.1	0.8	1.7
Intelligence (Savage-Jansen 2018)	1.1	3.5	10.2	-1.4	-0.8	0.4	-3.2	0.5	2.8
Neuroticism (Nagel 2018)	0.4	0.9	3.6	1.1	0.6	0.1	1.9	0.5	0.1
Schizophrenia (2018)	0.6	1.3	3.9	0.0	-0.4	1.3	-2.0	1.1	0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	1.8	0.4	0.0	-0.4	1.4	-0.1	-1.0
Worry (Nagel 2018)	0.8	1.8	6.0	1.3	1.3	0.9	2.5	0.3	-0.7
Alzheimer’s Disease (in mother)	0.4	0.4	1.1	-1.1	-0.2	0.8	-0.8	-0.4	0.1
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.8	-0.2	0.6	0.7	-0.4	-0.2
Alzheimer’s Disease (including proxy)	0.5	0.8	2.9	-1.7	-0.5	0.7	-0.9	-0.3	0.4
Crohns Disease (2017)	0.6	1.2	3.0	-1.3	-0.1	1.7	-0.8	1.2	0.8
Irritable Bowel Disease (IBD)	0.6	1.5	5.3	-1.7	-0.6	2.3	-0.4	0.1	0.6
Ulcerative Colitis (UC)	0.5	1.0	2.9	-1.3	-0.9	1.7	-0.1	-0.5	0.4
Major Depression (MDD)	0.2	0.2	0.5	-0.3	-0.7	-0.3	0.3	0.7	0.3
Reaction Time	0.6	1.1	4.4	-0.5	-0.9	-2.1	0.7	0.6	-0.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	5.4	-0.5	-0.4	0.3	-2.3	0.4	1.8
Breast Cancer	0.4	0.9	2.3	0.9	0.6	-1.0	0.9	-1.5	-0.7
Ovarian Cancer	0.7	1.0	2.4	-0.5	-0.4	-0.9	-0.3	1.4	1.5
Prostate Cancer	0.6	0.9	2.5	1.4	0.3	-0.5	0.7	-1.6	-0.1
Age at First Birth	0.5	0.7	3.3	-0.1	-0.7	-0.4	-1.8	-0.7	-0.1
Bipolar Disorder (2011)	1.0	0.9	2.5	-0.2	0.7	1.5	-1.6	-0.3	-0.3
Body Mass Index (BMI) (2010)	0.9	1.2	3.8	1.0	0.6	-1.9	0.4	-1.3	-0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.4	0.3	-0.3	-0.2	0.7	-0.5	-0.7
Crohns Disease (2012)	0.7	1.2	5.4	-0.2	1.1	2.3	0.4	0.0	-0.5
Mean Putamen Volume	1.3	1.4	3.3	1.7	1.8	0.9	0.8	-0.7	-0.7
Fasting Glucose	0.2	0.2	0.9	-0.1	0.1	0.9	-0.2	-0.6	0.0
HbA1C	1.2	1.3	2.0	-1.4	-1.4	1.0	0.4	1.3	1.0
HDL Cholesterol	0.2	0.4	0.9	0.8	0.9	-0.1	-0.4	-0.6	-0.4
LDL Cholesterol	0.8	1.2	3.9	1.4	2.0	1.1	-0.2	-0.4	0.1
Lupus	0.3	0.4	1.8	-0.6	-0.6	-1.3	-0.0	-0.0	0.0
Neuroticism (2016)	0.4	0.5	2.8	0.4	-0.2	1.7	0.3	-0.0	-0.2
Primary Biliary Cirrhosis	0.3	0.5	1.6	0.7	-0.1	0.0	1.3	0.5	-0.7
Rheumatoid Arthritis	0.7	1.0	1.7	-1.3	-1.1	0.4	-1.1	0.5	1.2
Schizophrenia (2014)	0.7	1.4	4.8	-0.3	-0.5	2.2	-1.1	1.5	0.5
Triglycerides	0.3	0.5	0.9	0.7	1.0	0.7	0.8	-0.8	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.2	0.5	0.3	1.1	-0.5	0.2	-0.3
Ulcerative Colitis	0.4	0.6	1.7	-1.0	-0.4	1.3	-0.5	-0.7	-0.1
Blood Eosinophil Count	0.6	4.3	7.9	-2.8	-2.0	-2.3	-1.7	1.8	1.6
Blood Platelet Count	0.1	1.3	4.5	-0.0	-0.1	0.8	2.1	0.4	-1.7
Blood Red Count	1.8	17.4	22.6	3.8	4.7	4.7	0.2	-4.7	-4.7
Blood White Count	3.1	22.9	46.0	-6.8	-4.8	-2.6	-2.0	4.5	6.1
Heel T-Score	0.3	2.5	10.0	0.9	0.9	3.2	-0.6	-0.9	-1.5
BMI	0.1	0.6	1.1	0.5	0.6	0.8	-0.9	-0.6	-1.0
Height	0.1	2.8	10.6	-2.1	-3.2	-1.0	0.2	0.8	0.8
Waist Hip Ratio (WHR)	0.9	4.2	8.1	1.9	2.9	2.4	1.4	-0.8	-2.3
Systolic Blood Pressure	0.2	1.2	4.9	-0.3	0.1	2.2	0.3	1.5	0.3
Smoking Status	1.4	3.4	6.5	-2.5	-2.2	-0.5	-0.3	1.6	2.5
Allergy or Eczema	0.3	0.7	1.4	0.8	1.2	0.7	-0.1	0.9	0.9
Cardiovascular Disease	0.0	0.1	0.3	-0.3	-0.5	0.1	-0.2	-0.5	-0.1
Hypothyroidism (self reported)	0.3	0.7	2.9	0.1	-0.7	-1.7	0.2	-0.7	-0.4
Respiratory disease	0.3	0.6	2.1	0.8	0.3	0.1	-0.2	1.5	0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.7	-0.8	-0.8	-1.6	1.0	1.2	0.9
Lung FEV1/FVC ratio	0.5	2.4	7.4	-0.9	-2.4	-2.7	0.5	-0.2	-0.5
Lung FVC	0.1	0.4	0.8	0.7	0.2	-0.6	0.9	-0.1	0.7
Neuroticism	0.4	1.0	3.8	0.4	-0.1	0.1	2.0	1.0	1.1
Chronotype (morning person)	2.1	4.9	7.8	-2.8	-1.5	-2.7	-1.8	1.9	2.3
Hair Pigment	0.1	3.4	6.3	-2.5	-2.1	-1.6	-0.1	2.0	1.8
Tanning	0.0	0.2	0.5	-0.7	-0.3	-0.6	0.3	-0.2	-0.6
Hand grip strength (left)	0.3	0.8	2.4	-1.5	-0.9	0.0	-0.8	0.1	1.0
Number of treatments/medications taken	0.5	0.9	1.6	-0.8	-0.7	0.2	-1.0	1.2	1.3
Average weekly spirits intake	2.0	2.5	5.6	-1.9	-2.4	-0.8	-2.0	0.5	0.9
Sensitivity / hurt feelings	0.1	0.2	0.7	0.2	-0.1	0.9	0.1	-0.7	0.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.9	-0.7	0.2	0.2	0.4	0.6	2.0
Hearing difficulty/problems: Yes	0.2	0.3	1.1	-0.5	0.3	-0.1	-1.1	0.3	0.4
Relative age of first facial hair	0.4	0.8	2.4	-1.5	-0.8	1.0	-0.4	0.7	0.0
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	4.3	-1.2	0.2	2.1	0.1	1.1	1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.1	1.2	1.5	1.1	0.3	0.3	-0.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.9	0.2	0.0	1.4	-1.2	-0.0	0.1
Systolic blood pressure, automated reading	0.6	1.8	9.0	0.2	0.5	3.0	0.6	-0.1	-1.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.5	0.5	0.3	-1.6	1.0	0.1	0.0
Angina	0.4	0.5	2.0	0.8	0.4	1.4	-0.1	-0.4	0.0
Medication for hormone replacement therapy	0.6	0.7	2.7	1.1	-0.1	-1.6	0.2	0.1	-0.0
Vitamin and mineral supplements	0.1	0.1	0.3	-0.0	0.5	-0.4	0.1	0.3	-0.6
Supplements: Zinc	0.9	0.9	4.6	-0.1	0.4	2.1	-0.9	-0.3	0.1
Medication: Co-codamol	0.5	0.6	1.9	-0.0	-0.8	-0.8	0.6	1.4	-0.0
Medication: Metformin	3.5	5.0	9.7	-2.1	-2.3	-3.1	0.4	2.6	1.8
Diabetes (father)	0.3	0.3	0.6	0.3	0.0	-0.7	0.4	0.8	-0.7
Diabetes (mother)	0.2	0.3	0.6	-0.5	-0.3	-0.5	-0.4	0.8	0.6
Severe depression (siblings)	1.3	1.5	3.6	-0.9	-1.2	-1.0	0.3	1.5	1.9
Pack years adult smoking proportion	0.4	0.6	2.4	-0.6	0.9	0.0	-0.2	1.6	-0.1
Impedance of leg (right)	0.3	1.7	5.5	-2.4	-1.3	-0.5	0.8	1.2	0.7
Leg fat-free mass (left)	0.0	0.1	0.5	0.0	-0.2	-0.7	-0.4	0.0	0.0
Trunk fat percentage	0.2	0.8	1.7	-1.3	-0.6	-1.1	-0.0	1.3	-0.1
Hand grip strength (right)	0.4	1.0	2.3	-1.2	-1.1	0.8	-1.5	0.1	0.6
Townsend deprivation index at recruitment	0.8	1.1	2.5	-1.1	-0.3	-0.8	-0.4	1.3	1.6
Current tobacco smoking	1.1	1.7	4.5	-1.4	-1.1	-1.0	-0.3	1.2	2.1
Average weekly fortified wine intake	0.4	0.4	2.0	1.4	0.7	-0.3	0.2	-0.1	-0.3
Maternal smoking around birth	0.3	0.4	1.7	-0.1	0.6	1.3	0.5	-0.1	-0.2
Fed-up feelings	0.7	1.2	2.9	-0.2	-0.2	-1.3	1.2	1.1	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.0	-1.3	-1.2	-0.8	-0.2	0.8	1.7
Relative age voice broke	0.3	0.5	1.9	-0.3	-0.6	0.3	-1.4	-0.2	0.8
Taking other prescription medications	0.4	0.6	1.3	-1.1	-0.6	0.4	-0.1	0.9	0.8
Age when periods started (menarche)	2.3	5.6	15.5	-3.6	-3.9	-1.4	0.6	1.0	1.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	5.0	0.3	0.3	-1.4	-2.2	0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.1	0.4	-0.8	0.9	1.0	-0.6	-1.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.2	0.2	0.8	-0.6	1.1	0.6	-0.5
Qualifications: CSEs or equivalent	0.2	0.3	1.3	-0.3	0.3	-1.1	0.1	0.1	-0.3
Serious illness, injury or assault to yourself	0.5	0.6	2.0	0.8	1.4	-0.1	-0.8	-0.3	0.2
High blood pressure	0.4	1.1	3.3	-1.2	-1.8	-0.7	-0.1	0.4	1.1
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.6	0.5	0.6	0.1	0.1	0.7
Multivitamins +/- minerals	0.1	0.2	0.6	-0.2	-0.8	0.0	0.3	-0.0	0.6
Stomach or abdominal pain in last month	2.1	2.6	6.2	1.9	2.5	1.2	1.6	-0.5	-1.5
Supplements: Glucosamine	0.2	0.3	1.2	0.3	-0.2	1.1	-0.3	-0.6	-0.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.6	0.8	-0.4	-1.6	1.9	-0.1	-0.3
Medication: Atenolol	0.6	0.8	2.0	-0.8	-1.4	-0.7	-0.7	0.7	0.8
Medication: Levothyroxine sodium	1.3	2.2	6.6	0.3	-1.3	-2.6	1.6	-1.3	-0.7
Sitting height	0.2	1.2	5.3	-0.8	-2.3	-0.4	1.0	-0.2	0.4
Chronic bronchitis/emphysema (father)	0.9	1.1	2.2	-1.2	-0.5	-0.3	-0.9	1.5	1.2
High blood pressure (mother)	0.6	0.9	2.0	0.9	1.3	0.1	0.8	1.4	-0.3
Body mass index (BMI)	0.0	0.2	0.4	-0.3	0.3	0.1	-0.4	0.4	-0.7
Impedance of leg (left)	0.3	1.4	4.5	-2.1	-1.2	-0.5	0.4	1.2	0.8
Leg predicted mass (left)	0.0	0.1	0.6	0.0	-0.3	-0.8	-0.4	0.0	0.0
Trunk fat mass	0.2	0.8	1.8	-1.3	-0.7	-0.9	-0.3	1.3	0.1
Waist circumference	0.2	0.6	1.7	0.3	1.3	0.6	-0.5	0.9	-0.5
Number of incorrect matches in round	0.3	0.4	0.9	0.7	0.4	0.7	0.7	1.0	-0.2
Past tobacco smoking	1.5	2.8	6.4	1.9	1.0	-0.3	1.2	-2.1	-2.5
Alcohol usually taken with meals	0.5	0.8	3.9	0.5	0.2	2.0	-0.7	-0.1	-0.2
Nervous feelings	0.6	1.2	2.5	0.9	1.5	1.6	1.3	0.3	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	4.0	-0.4	0.1	-0.0	-0.0	1.3	2.0
Hearing difficulty/problems with background noise	0.7	1.1	3.5	0.4	-0.6	-0.9	1.3	-1.9	-0.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	-0.1	-0.6	0.1	-0.5	-0.8	-0.9
Had menopause	0.2	0.3	0.6	0.8	0.5	0.8	0.4	0.0	-0.4
Had other major operations	0.3	0.4	0.8	0.7	0.8	0.7	-0.1	0.2	0.9
Forced vital capacity (FVC)	0.2	0.9	3.9	0.4	-0.7	-1.0	2.0	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	3.5	-0.9	-1.9	-0.3	-0.3	0.4	0.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	3.1	0.2	1.3	1.7	0.6	1.8	0.5
Qualifications: None of the above	0.2	0.4	1.3	-0.2	0.2	-1.2	-0.2	0.9	-0.4
Financial difficulties in last 2 years	0.6	0.9	1.6	0.2	0.5	-1.2	1.0	1.3	0.8
Mouth/teeth dental problems	1.4	2.2	3.4	1.9	1.1	1.1	1.8	-1.3	-1.5
Heart attack	0.1	0.2	0.3	0.5	0.6	0.1	-0.3	0.4	0.4
Allergy	0.5	1.1	3.1	-0.3	-0.4	-0.7	0.0	-1.8	-1.7
Pain all over the body in last month	0.5	0.6	2.0	-0.3	0.2	-1.4	0.3	0.9	0.7
Diabetes (self-reported)	1.6	2.5	5.4	-1.5	-1.3	-1.8	-0.3	2.3	1.5
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.7	-0.9	-1.1	-1.1	-0.6	1.4	1.9
Medication: Ramipril	0.2	0.3	0.9	0.1	0.1	0.9	0.3	-0.9	-0.0
Medication: Simvastatin	1.2	1.8	6.8	-1.4	-0.4	0.2	-2.6	0.6	1.2
Fluid intelligence score	0.7	1.5	4.4	-0.8	-0.4	0.4	-1.9	0.6	2.1
Illnesses of siblings	0.3	0.5	1.2	1.1	0.8	-0.0	-0.6	-0.9	-0.2
Neuroticism score	0.5	1.0	3.0	-0.4	-0.4	-0.6	1.7	0.8	1.4
Weight	0.1	0.5	1.0	-1.0	-0.8	-0.4	-0.5	1.0	0.2
Impedance of arm (right)	0.3	1.2	2.2	-1.5	-1.5	-0.5	0.2	0.8	1.3
Arm fat percentage (right)	0.1	0.2	0.5	-0.5	0.0	-0.4	-0.2	0.7	-0.5
Trunk fat-free mass	0.0	0.2	0.7	-0.1	-0.4	0.1	-0.8	0.5	0.3
Hip circumference	0.1	0.3	0.8	-0.4	-0.1	-0.5	-0.7	0.9	0.5
Time employed in main current job	0.9	1.0	3.6	-0.2	-0.4	-0.8	-0.5	1.2	1.9
Alcohol intake versus 10 years previously	0.4	0.7	2.7	0.7	1.6	0.8	0.2	-0.1	-0.4
Father’s age at death	1.7	2.3	8.3	1.3	-0.3	0.7	0.3	-2.9	-1.9
Worrier / anxious feelings	1.0	1.8	4.2	1.2	2.1	1.2	1.4	1.1	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.3	-0.2	0.5	-0.5	-0.2	2.1	1.7
Falls in the last year	1.2	1.6	2.5	1.6	0.9	0.9	1.5	-1.3	-1.3
Hair/balding pattern: Pattern 3	0.9	1.3	3.6	1.6	1.9	0.8	0.2	-0.8	-0.4
Number of live births	0.8	1.1	4.2	0.6	0.2	-0.8	2.0	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	6.0	0.5	-0.7	-1.6	2.5	-0.6	-0.2
Pulse rate	0.7	1.2	2.9	-0.2	-1.1	-0.2	1.4	-1.7	-1.1
Happiness	0.3	0.4	1.3	0.3	0.1	-0.6	1.1	0.9	-0.1
Noisy workplace	1.2	1.4	3.4	-1.7	-1.2	0.5	-0.7	1.9	0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.5	-0.7	-1.1	-0.3	-1.2	-1.9	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.2	-1.0	-0.3	0.3	-1.8	0.7	1.0
Mouth/teeth dental problems: Dentures	0.2	0.4	0.6	-0.7	-0.5	0.5	-0.8	-0.8	-0.1
Asthma	0.4	0.8	2.6	0.3	0.6	-0.3	-0.9	1.6	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.7	1.2	1.6	-0.2	0.2	0.5	0.1
Medication: Cholesterol lowering	0.3	0.5	1.3	-0.8	-1.2	0.1	-0.7	0.6	-0.0
Depression (self-reported)	1.1	1.3	6.9	0.2	-0.4	-0.9	2.6	-0.2	-0.2
Medication: Lansoprazole	0.4	0.5	1.9	-0.5	0.1	0.6	-1.4	0.3	0.6
Prospective memory result	1.1	1.4	3.8	0.1	-0.7	-0.6	1.5	-1.3	-1.9
Lung cancer (father)	0.5	0.6	1.4	0.7	0.6	0.2	1.0	-0.8	-1.2
Illnesses of mother	0.6	0.8	1.9	0.6	-0.3	-0.0	1.3	-1.4	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	3.5	0.4	-0.6	-0.9	1.9	-0.3	0.0
Pulse wave Arterial Stiffness index	1.8	2.1	4.7	1.4	0.9	2.2	0.0	-1.1	-2.0
Impedance of arm (left)	0.3	1.5	2.6	-1.6	-1.5	-0.6	0.4	1.2	1.6
Arm fat mass (right)	0.1	0.3	1.0	-0.6	-0.2	-0.3	-0.3	1.0	-0.4
Trunk predicted mass	0.0	0.2	0.8	-0.2	-0.4	0.1	-0.9	0.6	0.3
Standing height	0.2	2.1	5.5	-1.6	-2.4	-0.5	-0.6	1.2	1.6
Length of working week for main job	2.1	2.3	4.3	1.4	2.1	0.5	1.1	-1.5	-2.1
Exposure to tobacco smoke at home	0.3	0.4	0.9	0.0	-0.2	0.5	0.9	0.9	-0.5
Breastfed as a baby	0.9	1.1	5.1	-0.4	-0.4	2.3	-1.1	-0.3	0.3
Tense / ‘highly strung’	0.4	0.6	2.4	0.5	0.7	1.6	0.7	-0.1	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.3	-0.2	0.6	1.2	0.8	1.8	1.7
Hair/balding pattern: Pattern 4	0.5	1.2	6.4	-0.4	-0.1	-0.4	-0.4	2.5	0.5
Birth weight of first child	2.1	3.8	5.9	-2.1	-1.5	-1.8	-1.5	2.2	2.4
Peak expiratory flow (PEF)	1.2	2.7	8.2	-1.1	-1.9	-2.9	1.7	0.3	0.7
Pulse wave reflection index	0.7	0.9	3.2	0.6	0.1	1.8	-1.0	0.7	-0.0
Ever highly irritable/argumentative for 2 days	5.7	6.8	18.6	-2.7	-2.1	-1.4	0.1	4.3	3.0
Loud music exposure frequency	0.2	0.3	0.8	-0.2	-0.8	-0.1	-0.9	-0.0	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	0.5	0.0	0.3	0.2	-0.1	0.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	2.8	-1.7	-1.2	-1.2	-1.0	0.9	1.0
Blood clot in the leg (DVT)	0.7	0.9	2.4	0.3	0.1	1.6	1.4	0.9	-0.2
Medication: Paracetamol	0.6	1.0	2.8	0.2	0.1	-1.4	1.7	0.6	0.9
Headache pain in last month	0.6	1.1	3.0	1.0	1.7	-0.5	1.4	0.4	-0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	0.3	0.7	-0.1	0.2	-0.7	-0.3
Glaucoma (self-reported)	1.1	1.3	5.9	-0.8	-0.0	0.7	-0.5	2.4	0.7
Gout (self-reported)	0.1	0.2	0.5	0.3	-0.3	-0.7	0.6	0.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.4	0.3	-1.0	-1.9	0.6	-1.8	-0.7
Medication: Amlodipine	0.2	0.2	0.5	-0.5	-0.5	-0.4	0.2	0.7	0.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.9	-0.3	-0.4	-1.1	-0.1	2.2	1.3
Birth weight	2.2	4.8	9.1	-2.6	-2.7	-0.5	-1.8	1.5	3.0
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	-0.7	-0.3	1.1	0.0	0.8	0.1
High blood pressure (siblings)	0.8	1.1	4.6	-0.4	-1.0	-0.6	2.1	0.2	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.6	2.8	0.5	-0.4	-0.5	1.7	0.0	0.6
Body fat percentage	0.2	0.6	1.6	-1.3	-0.5	-0.7	-0.0	1.1	-0.3
Leg fat percentage (right)	0.2	0.6	2.2	-1.5	-0.1	0.0	-0.1	1.0	-0.7
Arm fat-free mass (right)	0.0	0.1	0.3	-0.3	-0.3	-0.5	-0.5	0.5	-0.0
Exposure to tobacco smoke outside home	0.7	1.0	2.6	-0.7	-0.5	-1.1	-1.6	0.8	0.8
Comparative body size at age 10	0.4	1.2	2.4	0.7	0.0	-1.6	1.2	-1.2	-1.1
Number of full brothers	1.1	1.4	4.0	-0.7	-0.1	2.0	-2.0	0.4	0.3
Worry too long after embarrassment	0.5	0.9	3.5	-1.0	-0.8	-0.2	0.1	0.5	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.1	-0.3	0.2	1.7	1.6	0.5	-0.5
Wheeze or whistling in the chest in last year	1.2	2.1	4.5	1.4	2.1	1.4	-1.7	1.1	-0.2
Number of children fathered	0.4	0.4	0.8	-0.7	-0.0	-0.8	-0.9	0.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.6	-1.2	-1.3	-0.9	0.0	1.0	1.9
Age at first live birth	0.4	0.7	3.6	-0.2	0.1	0.6	-1.9	-0.0	0.4
Pulse wave peak to peak time	1.8	2.1	4.4	-1.5	-1.0	-2.0	-0.0	1.1	2.1
Health satisfaction	1.0	1.3	3.0	-1.2	-0.8	0.8	-0.6	1.7	1.2
Shortness of breath walking on level ground	1.0	1.2	3.5	-0.7	-0.0	-0.0	-0.8	1.6	1.9
Qualifications: College or University degree	0.2	0.7	2.0	0.3	-0.8	1.4	0.0	-1.2	-0.1
Eye problems/disorders: None of the above	0.2	0.2	0.6	0.4	0.2	-0.6	-0.7	-0.5	0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.0	1.4	0.8	-0.9	0.6	-0.2	-0.7
Emphysema/chronic bronchitis	1.0	1.1	3.0	-1.7	-1.3	0.6	-0.2	0.5	1.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	-0.8	-0.5	0.6	-0.1	0.1	-0.5
Neck or shoulder pain in last month	0.6	0.8	2.9	1.0	1.7	-0.1	0.9	0.2	-0.4
Medication: Blood pressure	0.2	0.3	0.7	-0.6	-0.8	0.1	-0.1	0.8	0.5
Angina (self-reported)	0.2	0.3	1.2	0.5	0.1	1.1	-0.2	-0.2	0.1
Migraine (self-reported)	0.7	0.9	1.6	0.6	1.2	1.3	1.1	0.9	-0.1
Medication: Ibuprofen	0.9	1.0	4.2	1.4	2.1	-0.0	-0.1	0.3	-0.0
Medication: Allopurinol	1.2	1.6	3.1	-1.3	-1.6	-0.3	0.0	1.5	1.8
Medication: Omeprazole	1.6	1.9	6.4	0.4	-0.2	-1.0	0.8	-2.5	-1.8
Medication: Seretide 50 evohaler	0.2	0.3	1.0	0.6	0.5	-0.2	1.0	-0.2	-0.1
Mean time to correctly identify matches	0.3	0.5	1.8	1.0	0.5	-0.2	0.3	-0.1	-1.4
Heart disease (mother)	0.4	0.5	1.7	-0.8	0.3	0.7	-0.3	0.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.7	-1.9	-1.8	-0.6	-0.0	0.2	1.9
Whole body fat mass	0.1	0.4	0.9	-1.0	-0.4	-0.6	-0.3	1.0	-0.2
Leg fat mass (right)	0.1	0.5	1.4	-1.2	-0.2	-0.2	-0.4	0.9	-0.6
Arm predicted mass (right)	0.1	0.3	0.5	-0.4	-0.3	-0.7	-0.7	0.7	0.2
Pulse rate, automated reading	0.6	2.0	4.5	-0.3	-1.7	-1.1	1.3	-2.1	-1.2
Alcohol intake frequency.	1.6	3.7	5.7	1.9	2.2	0.7	2.3	-1.5	-2.4
Comparative height size at age 10	0.0	0.2	0.5	0.1	-0.7	-0.5	0.2	-0.4	-0.1
Number of full sisters	1.4	1.7	3.2	-1.8	-1.4	-1.7	0.1	1.1	1.1
Suffer from ‘nerves’	1.4	2.3	7.1	1.6	1.8	-0.7	2.7	-0.3	-0.0
Overall health rating	0.4	0.9	2.4	-1.5	-0.6	0.1	-1.3	0.4	0.9
Chest pain or discomfort	1.1	1.6	4.5	-1.3	-0.7	0.4	-2.1	0.7	1.6
Had major operations	1.3	1.5	3.9	-1.1	-0.5	0.4	-1.4	2.0	1.2
Age at last live birth	0.1	0.2	0.7	-0.1	0.1	-0.1	-0.9	-0.2	0.3
Family relationship satisfaction	1.2	1.5	3.6	1.6	1.9	0.8	1.4	0.1	-0.3
Leg pain on walking	1.5	1.9	4.0	1.4	2.0	1.5	-0.9	-0.9	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	4.9	0.2	-0.1	-1.1	2.2	0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.5	-0.6	-0.7	0.2	1.2	-0.5	-0.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.4	-0.5	-1.8	0.7	0.5	-0.8	-0.5
Medication: Aspirin	0.3	0.5	1.7	0.4	-0.3	-0.5	-0.5	-1.3	-0.5
Supplements: Vitamin C	0.2	0.3	0.8	0.2	0.9	0.1	-0.2	0.6	0.6
Knee pain experienced in last month	0.5	0.8	1.6	0.7	0.4	0.6	-1.1	-1.3	-0.9
Hypertension (Self-reported)	0.4	1.0	3.6	-1.2	-1.9	-0.2	-0.2	0.3	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	7.4	-0.1	-0.6	0.1	-0.7	-2.7	-0.9
Illnesses of father: Heart disease	0.7	0.9	3.7	-0.0	-1.3	-0.2	1.9	0.1	-0.5
Illnesses of siblings: Diabetes	2.3	2.8	5.3	-2.3	-2.0	-0.5	-1.0	1.1	2.3
Smoking status: Previous	0.8	1.2	2.4	-1.3	-0.7	0.5	-0.2	1.6	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.2	-0.2	-1.1	-1.5	0.5	-0.7	0.1
Whole body fat-free mass	0.0	0.2	0.8	-0.1	-0.4	-0.4	-0.9	0.4	0.4
Leg fat-free mass (right)	0.0	0.2	0.6	0.3	-0.2	-0.7	-0.8	-0.2	0.1
Arm fat percentage (left)	0.1	0.4	1.2	-0.8	-0.2	-0.6	-0.1	1.1	-0.1
Average weekly red wine intake	0.8	1.1	2.2	1.5	0.4	1.3	-1.1	-1.2	-0.3
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.7	-0.4	-0.8	1.9	0.2	-0.7	-0.6
Mood swings	1.0	1.9	5.4	0.0	0.3	-1.7	2.3	1.3	1.2
Loneliness, isolation	0.4	0.6	1.6	0.2	0.4	-0.9	0.7	0.5	1.3
Long-standing illness, disability or infirmity	0.4	0.7	1.6	-0.3	0.7	-1.0	0.5	1.3	0.8
Ever had bowel cancer screening	0.5	0.5	1.4	0.6	0.5	0.6	-1.2	0.8	0.4
Diabetes diagnosed by doctor	1.7	2.9	4.4	-1.5	-1.9	-2.1	0.2	2.1	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	5.4	0.2	-0.6	-2.3	0.7	-0.1	0.0
Friendships satisfaction	0.1	0.1	0.4	-0.6	-0.4	0.4	0.0	-0.2	-0.2
Qualifications: nursing, teaching	0.6	0.9	3.0	0.6	0.1	1.7	-0.4	-0.8	-1.2
Commuting to job workplace: Walk	2.8	3.1	7.3	-0.6	-0.3	-2.7	-2.4	1.4	1.7
Eye problems/disorders: Cataract	0.4	0.5	1.3	-0.5	0.3	0.8	-0.1	1.1	0.8
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	-0.4	0.0	-0.3	0.0	0.2	0.3
Medication for cholesterol	0.4	0.6	1.5	-0.4	-0.0	1.2	0.6	1.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.6	0.5	0.6	-1.3	1.2	-0.8	-0.7
Back pain experienced in last month	0.1	0.1	0.7	-0.3	-0.1	0.0	0.8	0.0	-0.0
Mineral and other dietary supplements	0.3	0.4	1.0	0.1	0.4	-0.8	1.0	0.3	-0.5
Breast cancer (self-reported)	0.2	0.3	0.7	0.0	-0.3	-0.1	-0.6	0.8	0.8
Asthma (self-reported)	0.4	0.8	2.1	0.4	0.7	0.1	-0.9	1.4	1.0
Osteoporosis (self-reported)	0.8	1.0	2.2	0.2	1.4	0.6	1.5	1.2	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.8	0.2	0.2	0.4	-0.9	-0.5	-0.7
Medication: Aspirin	0.5	0.6	2.5	0.5	-0.2	-0.4	-0.2	-1.6	-0.9
Medication: Gliclazide	2.5	2.8	5.0	-1.4	-1.7	-2.2	0.2	1.9	1.8
Illnesses of father: None of the above (group 1)	0.9	1.1	2.9	0.3	0.6	0.5	-1.4	-1.7	-0.8
Smoking status: Current	1.0	1.6	4.3	-1.2	-1.0	-1.1	-0.4	1.1	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.8	-0.0	-0.6	0.0	-0.1	-0.4	-0.9
Whole body water mass	0.0	0.2	0.5	-0.1	-0.5	-0.5	-0.7	0.4	0.3
Leg predicted mass (right)	0.0	0.2	0.6	0.3	-0.1	-0.7	-0.7	-0.2	0.1
Arm fat mass (left)	0.1	0.4	1.5	-0.8	-0.2	-0.5	-0.2	1.2	-0.1
Number of self-reported non-cancer illnesses	0.7	1.2	3.1	0.0	0.1	1.8	-1.1	0.9	1.3
Average weekly champagne plus white wine intake	0.3	0.5	1.3	-0.3	-1.0	-1.1	-0.2	-0.1	0.6
Miserableness	1.1	1.9	6.0	-1.0	-0.5	-0.6	0.5	1.9	2.4
Guilty feelings	0.6	0.9	3.9	-0.3	-0.4	-1.1	0.0	0.5	2.0
Wears glasses or contact lenses	1.0	1.2	4.3	1.2	0.8	0.4	2.1	0.6	-0.3
Ever taken oral contraceptive pill	1.6	1.8	5.9	0.6	0.7	-0.9	-2.4	0.8	1.6
Hearing aid user	0.7	0.7	2.0	-0.9	-0.7	1.4	0.9	0.1	0.4
Mother’s age at death	1.2	1.5	4.7	-0.3	-0.1	0.4	-2.2	1.3	1.4
Financial situation satisfaction	0.7	0.9	3.1	-0.6	-0.6	0.8	1.8	1.0	0.3
Tinnitus: Yes, now most or all of the time	1.9	2.3	8.4	-0.1	0.2	-2.9	-0.8	1.3	1.7
Commuting to job workplace: Public transport	0.6	0.8	1.6	-0.5	-1.3	-1.0	0.6	0.9	0.6
Eye problems/disorders: Glaucoma	1.0	1.1	2.1	-1.3	-0.7	1.3	-0.8	1.4	0.4
Medication: Blood pressure	0.5	0.9	1.6	-0.7	-1.1	-1.1	-0.4	-0.7	1.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	-0.4	0.3	-0.9	-0.4	0.5	0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	0.3	-0.1	0.3	-1.0	-0.8	0.2
High cholesterol (Self-reported)	0.4	0.7	1.9	0.6	0.5	0.9	-0.2	-1.4	-0.9
Medication: Bendroflumethiazide	0.3	0.5	2.1	0.2	0.1	0.0	-0.6	-1.4	-0.5
Medication: Paracetamol	0.8	1.2	4.8	-0.1	-0.3	-1.4	2.2	0.5	0.6
Medication: Lisinopril	0.2	0.2	0.5	-0.2	-0.6	-0.7	0.2	-0.6	0.3
Medication: Atorvastatin	1.4	1.7	2.3	1.5	0.8	-1.4	1.4	-1.0	-1.5
Illnesses of father: High blood pressure	1.4	1.7	4.3	-0.7	-0.5	-1.2	0.8	2.1	1.7
Alcohol drinker status: Never	0.7	0.8	2.7	0.1	-0.4	-1.4	1.6	0.2	0.1
Ever smoked	1.1	1.9	5.3	-1.4	-0.5	0.4	-1.0	1.7	2.3
Basal metabolic rate	0.0	0.2	0.4	-0.3	-0.5	-0.7	-0.6	0.5	0.2
Leg fat percentage (left)	0.1	0.5	1.5	-1.2	0.1	-0.0	-0.3	0.9	-0.7
Arm fat-free mass (left)	0.0	0.1	0.3	-0.1	-0.1	-0.3	-0.6	0.3	-0.2
Number of operations (self-reported)	1.4	2.1	5.7	-0.1	0.5	0.3	-2.4	1.8	1.8
Average weekly beer plus cider intake	1.7	2.5	5.3	-1.4	-1.6	-2.3	-0.6	1.6	1.4
Irritability	0.1	0.2	0.8	0.1	-0.5	0.1	-0.1	0.4	0.9
Risk taking	0.2	0.3	1.7	-0.2	-0.4	1.3	-0.1	0.5	0.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.4	2.1	1.1	0.4	1.2	-0.3	-0.8
Fractured/broken bones in last 5 years	0.8	1.0	2.5	-0.8	-1.2	-0.0	-1.2	0.2	1.6
Age started oral contraceptive pill	1.0	1.3	2.8	1.5	1.0	-0.7	0.6	-1.7	-0.8
Diastolic blood pressure, automated reading	1.3	4.0	9.6	0.5	-0.2	3.1	1.3	-2.4	-2.6
Ever depressed for a whole week	1.9	2.3	6.9	0.9	2.0	2.6	-0.5	1.3	0.2
Unable to work because of sickness or disability	1.2	1.6	5.8	-1.1	-0.8	-0.3	0.4	2.4	1.2
Commuting to job workplace: Cycle	0.2	0.2	1.2	-0.0	-0.2	-1.1	-0.4	0.3	-0.1
Myopia	0.6	0.9	2.2	-0.9	-0.6	-0.5	0.1	1.5	1.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.9	0.7	1.4	-0.0	0.3	-0.0	-0.7
Cholesterol lowering medication	0.2	0.3	1.0	0.3	0.8	-0.1	-0.5	-1.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.6	-0.4	-1.1	-1.9	0.8	-1.9	-1.1
Pain experienced in last month	0.6	1.0	3.6	-1.0	-1.9	-0.3	-1.0	-0.2	0.5
Supplements: Calcium	0.2	0.2	0.5	-0.5	-0.4	0.3	0.6	-0.1	0.7
Basal cell carcinoma (self-reported)	1.3	1.5	3.7	1.9	1.1	1.2	0.6	-0.8	-1.3
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	0.2	0.4	-0.2	-0.5	0.7	0.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.9	0.5	0.3	2.0	0.9	0.6	-0.3
Heart disease (siblings)	1.4	1.7	3.6	-1.4	-0.8	-0.0	-1.9	0.9	1.9
Alcohol drinker status: Previous	0.6	0.6	1.8	0.6	-0.1	-1.2	1.4	0.1	-0.3
Pack years of smoking	0.4	0.6	2.6	-0.2	1.0	0.1	-0.2	1.6	-0.3
Impedance of whole body	0.2	1.3	3.6	-1.9	-1.4	-0.4	0.6	0.9	0.9
Leg fat mass (left)	0.1	0.4	1.2	-1.1	-0.2	-0.2	-0.5	0.9	-0.5
Arm predicted mass (left)	0.0	0.1	0.2	-0.2	-0.3	-0.4	-0.4	0.4	-0.1