Hub : Genes

FMNL2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.263 0.0835 3.8e-04 0.143 NA 0.129 NA 0.156 8.0e-06 NA 2.3e-05 NA 3.1e-06
2 GTEx Cells Transformed fibroblasts 0.092 0.0360 9.9e-04 0.065 NA 0.077 NA 0.067 1.3e-05 NA 2.1e-06 NA 9.6e-06
3 GTEx Esophagus Mucosa 0.196 0.0730 9.7e-04 -0.004 NA -0.002 NA -0.004 7.7e-01 NA 4.6e-01 NA 8.3e-01
4 GTEx Skin Not Sun Exposed Suprapubic 0.184 0.0680 4.8e-03 0.004 NA -0.001 NA 0.008 1.8e-01 NA 3.8e-01 NA 1.0e-01
5 GTEx Thyroid 0.121 0.0470 1.9e-03 -0.004 NA 0.047 NA 0.004 9.8e-01 NA 1.7e-04 NA 1.5e-01
6 TCGA Thyroid Carcinoma 0.078 0.0280 3.7e-05 0.042 0.045 0.032 NA 0.044 5.5e-05 3.4e-05 4.2e-04 NA 3.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.5 1.7 0.5 0.5 1.3 -0.5 0.7 0.2
Bipolar Disorder or Schizophrenia 0.6 1.5 3.5 0.4 -0.0 1.8 -1.9 1.3 0.8
Depressed Affect (Nagel 2018) 0.4 0.8 1.5 0.6 0.6 -0.9 1.2 1.0 0.8
Depression (Nagel 2018) 0.5 0.7 2.9 -0.8 -0.1 -0.3 -0.1 0.8 1.7
Intelligence (Savage-Jansen 2018) 1.1 3.5 10.2 -1.4 -0.8 0.4 -3.2 0.5 2.8
Neuroticism (Nagel 2018) 0.4 0.9 3.6 1.1 0.6 0.1 1.9 0.5 0.1
Schizophrenia (2018) 0.6 1.3 3.9 0.0 -0.4 1.3 -2.0 1.1 0.9
Schizophrenia vs Biploar Disorder 0.4 0.5 1.8 0.4 0.0 -0.4 1.4 -0.1 -1.0
Worry (Nagel 2018) 0.8 1.8 6.0 1.3 1.3 0.9 2.5 0.3 -0.7
Alzheimer’s Disease (in mother) 0.4 0.4 1.1 -1.1 -0.2 0.8 -0.8 -0.4 0.1
Alzheimer’s Disease (in father) 0.3 0.3 0.6 -0.8 -0.2 0.6 0.7 -0.4 -0.2
Alzheimer’s Disease (including proxy) 0.5 0.8 2.9 -1.7 -0.5 0.7 -0.9 -0.3 0.4
Crohns Disease (2017) 0.6 1.2 3.0 -1.3 -0.1 1.7 -0.8 1.2 0.8
Irritable Bowel Disease (IBD) 0.6 1.5 5.3 -1.7 -0.6 2.3 -0.4 0.1 0.6
Ulcerative Colitis (UC) 0.5 1.0 2.9 -1.3 -0.9 1.7 -0.1 -0.5 0.4
Major Depression (MDD) 0.2 0.2 0.5 -0.3 -0.7 -0.3 0.3 0.7 0.3
Reaction Time 0.6 1.1 4.4 -0.5 -0.9 -2.1 0.7 0.6 -0.2
Verbal and Numeric Reasoning (VNR) 0.7 1.6 5.4 -0.5 -0.4 0.3 -2.3 0.4 1.8
Breast Cancer 0.4 0.9 2.3 0.9 0.6 -1.0 0.9 -1.5 -0.7
Ovarian Cancer 0.7 1.0 2.4 -0.5 -0.4 -0.9 -0.3 1.4 1.5
Prostate Cancer 0.6 0.9 2.5 1.4 0.3 -0.5 0.7 -1.6 -0.1
Age at First Birth 0.5 0.7 3.3 -0.1 -0.7 -0.4 -1.8 -0.7 -0.1
Bipolar Disorder (2011) 1.0 0.9 2.5 -0.2 0.7 1.5 -1.6 -0.3 -0.3
Body Mass Index (BMI) (2010) 0.9 1.2 3.8 1.0 0.6 -1.9 0.4 -1.3 -0.3
Coronary Artery Disease (CAD) 0.2 0.2 0.4 0.3 -0.3 -0.2 0.7 -0.5 -0.7
Crohns Disease (2012) 0.7 1.2 5.4 -0.2 1.1 2.3 0.4 0.0 -0.5
Mean Putamen Volume 1.3 1.4 3.3 1.7 1.8 0.9 0.8 -0.7 -0.7
Fasting Glucose 0.2 0.2 0.9 -0.1 0.1 0.9 -0.2 -0.6 0.0
HbA1C 1.2 1.3 2.0 -1.4 -1.4 1.0 0.4 1.3 1.0
HDL Cholesterol 0.2 0.4 0.9 0.8 0.9 -0.1 -0.4 -0.6 -0.4
LDL Cholesterol 0.8 1.2 3.9 1.4 2.0 1.1 -0.2 -0.4 0.1
Lupus 0.3 0.4 1.8 -0.6 -0.6 -1.3 -0.0 -0.0 0.0
Neuroticism (2016) 0.4 0.5 2.8 0.4 -0.2 1.7 0.3 -0.0 -0.2
Primary Biliary Cirrhosis 0.3 0.5 1.6 0.7 -0.1 0.0 1.3 0.5 -0.7
Rheumatoid Arthritis 0.7 1.0 1.7 -1.3 -1.1 0.4 -1.1 0.5 1.2
Schizophrenia (2014) 0.7 1.4 4.8 -0.3 -0.5 2.2 -1.1 1.5 0.5
Triglycerides 0.3 0.5 0.9 0.7 1.0 0.7 0.8 -0.8 -0.2
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.2 0.5 0.3 1.1 -0.5 0.2 -0.3
Ulcerative Colitis 0.4 0.6 1.7 -1.0 -0.4 1.3 -0.5 -0.7 -0.1
Blood Eosinophil Count 0.6 4.3 7.9 -2.8 -2.0 -2.3 -1.7 1.8 1.6
Blood Platelet Count 0.1 1.3 4.5 -0.0 -0.1 0.8 2.1 0.4 -1.7
Blood Red Count 1.8 17.4 22.6 3.8 4.7 4.7 0.2 -4.7 -4.7
Blood White Count 3.1 22.9 46.0 -6.8 -4.8 -2.6 -2.0 4.5 6.1
Heel T-Score 0.3 2.5 10.0 0.9 0.9 3.2 -0.6 -0.9 -1.5
BMI 0.1 0.6 1.1 0.5 0.6 0.8 -0.9 -0.6 -1.0
Height 0.1 2.8 10.6 -2.1 -3.2 -1.0 0.2 0.8 0.8
Waist Hip Ratio (WHR) 0.9 4.2 8.1 1.9 2.9 2.4 1.4 -0.8 -2.3
Systolic Blood Pressure 0.2 1.2 4.9 -0.3 0.1 2.2 0.3 1.5 0.3
Smoking Status 1.4 3.4 6.5 -2.5 -2.2 -0.5 -0.3 1.6 2.5
Allergy or Eczema 0.3 0.7 1.4 0.8 1.2 0.7 -0.1 0.9 0.9
Cardiovascular Disease 0.0 0.1 0.3 -0.3 -0.5 0.1 -0.2 -0.5 -0.1
Hypothyroidism (self reported) 0.3 0.7 2.9 0.1 -0.7 -1.7 0.2 -0.7 -0.4
Respiratory disease 0.3 0.6 2.1 0.8 0.3 0.1 -0.2 1.5 0.8
Type 2 Diabetes (T2D) (2018) 0.6 1.2 2.7 -0.8 -0.8 -1.6 1.0 1.2 0.9
Lung FEV1/FVC ratio 0.5 2.4 7.4 -0.9 -2.4 -2.7 0.5 -0.2 -0.5
Lung FVC 0.1 0.4 0.8 0.7 0.2 -0.6 0.9 -0.1 0.7
Neuroticism 0.4 1.0 3.8 0.4 -0.1 0.1 2.0 1.0 1.1
Chronotype (morning person) 2.1 4.9 7.8 -2.8 -1.5 -2.7 -1.8 1.9 2.3
Hair Pigment 0.1 3.4 6.3 -2.5 -2.1 -1.6 -0.1 2.0 1.8
Tanning 0.0 0.2 0.5 -0.7 -0.3 -0.6 0.3 -0.2 -0.6
Hand grip strength (left) 0.3 0.8 2.4 -1.5 -0.9 0.0 -0.8 0.1 1.0
Number of treatments/medications taken 0.5 0.9 1.6 -0.8 -0.7 0.2 -1.0 1.2 1.3
Average weekly spirits intake 2.0 2.5 5.6 -1.9 -2.4 -0.8 -2.0 0.5 0.9
Sensitivity / hurt feelings 0.1 0.2 0.7 0.2 -0.1 0.9 0.1 -0.7 0.2
Frequency of depressed mood in last 2 weeks 0.6 0.8 3.9 -0.7 0.2 0.2 0.4 0.6 2.0
Hearing difficulty/problems: Yes 0.2 0.3 1.1 -0.5 0.3 -0.1 -1.1 0.3 0.4
Relative age of first facial hair 0.4 0.8 2.4 -1.5 -0.8 1.0 -0.4 0.7 0.0
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 4.3 -1.2 0.2 2.1 0.1 1.1 1.0
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.1 1.2 1.5 1.1 0.3 0.3 -0.3
Ever had hysterectomy (womb removed) 0.5 0.6 1.9 0.2 0.0 1.4 -1.2 -0.0 0.1
Systolic blood pressure, automated reading 0.6 1.8 9.0 0.2 0.5 3.0 0.6 -0.1 -1.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.5 0.5 0.3 -1.6 1.0 0.1 0.0
Angina 0.4 0.5 2.0 0.8 0.4 1.4 -0.1 -0.4 0.0
Medication for hormone replacement therapy 0.6 0.7 2.7 1.1 -0.1 -1.6 0.2 0.1 -0.0
Vitamin and mineral supplements 0.1 0.1 0.3 -0.0 0.5 -0.4 0.1 0.3 -0.6
Supplements: Zinc 0.9 0.9 4.6 -0.1 0.4 2.1 -0.9 -0.3 0.1
Medication: Co-codamol 0.5 0.6 1.9 -0.0 -0.8 -0.8 0.6 1.4 -0.0
Medication: Metformin 3.5 5.0 9.7 -2.1 -2.3 -3.1 0.4 2.6 1.8
Diabetes (father) 0.3 0.3 0.6 0.3 0.0 -0.7 0.4 0.8 -0.7
Diabetes (mother) 0.2 0.3 0.6 -0.5 -0.3 -0.5 -0.4 0.8 0.6
Severe depression (siblings) 1.3 1.5 3.6 -0.9 -1.2 -1.0 0.3 1.5 1.9
Pack years adult smoking proportion 0.4 0.6 2.4 -0.6 0.9 0.0 -0.2 1.6 -0.1
Impedance of leg (right) 0.3 1.7 5.5 -2.4 -1.3 -0.5 0.8 1.2 0.7
Leg fat-free mass (left) 0.0 0.1 0.5 0.0 -0.2 -0.7 -0.4 0.0 0.0
Trunk fat percentage 0.2 0.8 1.7 -1.3 -0.6 -1.1 -0.0 1.3 -0.1
Hand grip strength (right) 0.4 1.0 2.3 -1.2 -1.1 0.8 -1.5 0.1 0.6
Townsend deprivation index at recruitment 0.8 1.1 2.5 -1.1 -0.3 -0.8 -0.4 1.3 1.6
Current tobacco smoking 1.1 1.7 4.5 -1.4 -1.1 -1.0 -0.3 1.2 2.1
Average weekly fortified wine intake 0.4 0.4 2.0 1.4 0.7 -0.3 0.2 -0.1 -0.3
Maternal smoking around birth 0.3 0.4 1.7 -0.1 0.6 1.3 0.5 -0.1 -0.2
Fed-up feelings 0.7 1.2 2.9 -0.2 -0.2 -1.3 1.2 1.1 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.0 -1.3 -1.2 -0.8 -0.2 0.8 1.7
Relative age voice broke 0.3 0.5 1.9 -0.3 -0.6 0.3 -1.4 -0.2 0.8
Taking other prescription medications 0.4 0.6 1.3 -1.1 -0.6 0.4 -0.1 0.9 0.8
Age when periods started (menarche) 2.3 5.6 15.5 -3.6 -3.9 -1.4 0.6 1.0 1.5
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 5.0 0.3 0.3 -1.4 -2.2 0.5 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 2.1 0.4 -0.8 0.9 1.0 -0.6 -1.5
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 1.2 0.2 0.8 -0.6 1.1 0.6 -0.5
Qualifications: CSEs or equivalent 0.2 0.3 1.3 -0.3 0.3 -1.1 0.1 0.1 -0.3
Serious illness, injury or assault to yourself 0.5 0.6 2.0 0.8 1.4 -0.1 -0.8 -0.3 0.2
High blood pressure 0.4 1.1 3.3 -1.2 -1.8 -0.7 -0.1 0.4 1.1
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.5 0.6 0.5 0.6 0.1 0.1 0.7
Multivitamins +/- minerals 0.1 0.2 0.6 -0.2 -0.8 0.0 0.3 -0.0 0.6
Stomach or abdominal pain in last month 2.1 2.6 6.2 1.9 2.5 1.2 1.6 -0.5 -1.5
Supplements: Glucosamine 0.2 0.3 1.2 0.3 -0.2 1.1 -0.3 -0.6 -0.3
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 3.6 0.8 -0.4 -1.6 1.9 -0.1 -0.3
Medication: Atenolol 0.6 0.8 2.0 -0.8 -1.4 -0.7 -0.7 0.7 0.8
Medication: Levothyroxine sodium 1.3 2.2 6.6 0.3 -1.3 -2.6 1.6 -1.3 -0.7
Sitting height 0.2 1.2 5.3 -0.8 -2.3 -0.4 1.0 -0.2 0.4
Chronic bronchitis/emphysema (father) 0.9 1.1 2.2 -1.2 -0.5 -0.3 -0.9 1.5 1.2
High blood pressure (mother) 0.6 0.9 2.0 0.9 1.3 0.1 0.8 1.4 -0.3
Body mass index (BMI) 0.0 0.2 0.4 -0.3 0.3 0.1 -0.4 0.4 -0.7
Impedance of leg (left) 0.3 1.4 4.5 -2.1 -1.2 -0.5 0.4 1.2 0.8
Leg predicted mass (left) 0.0 0.1 0.6 0.0 -0.3 -0.8 -0.4 0.0 0.0
Trunk fat mass 0.2 0.8 1.8 -1.3 -0.7 -0.9 -0.3 1.3 0.1
Waist circumference 0.2 0.6 1.7 0.3 1.3 0.6 -0.5 0.9 -0.5
Number of incorrect matches in round 0.3 0.4 0.9 0.7 0.4 0.7 0.7 1.0 -0.2
Past tobacco smoking 1.5 2.8 6.4 1.9 1.0 -0.3 1.2 -2.1 -2.5
Alcohol usually taken with meals 0.5 0.8 3.9 0.5 0.2 2.0 -0.7 -0.1 -0.2
Nervous feelings 0.6 1.2 2.5 0.9 1.5 1.6 1.3 0.3 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 4.0 -0.4 0.1 -0.0 -0.0 1.3 2.0
Hearing difficulty/problems with background noise 0.7 1.1 3.5 0.4 -0.6 -0.9 1.3 -1.9 -0.6
Hair/balding pattern: Pattern 2 0.3 0.4 0.8 -0.1 -0.6 0.1 -0.5 -0.8 -0.9
Had menopause 0.2 0.3 0.6 0.8 0.5 0.8 0.4 0.0 -0.4
Had other major operations 0.3 0.4 0.8 0.7 0.8 0.7 -0.1 0.2 0.9
Forced vital capacity (FVC) 0.2 0.9 3.9 0.4 -0.7 -1.0 2.0 -0.3 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 3.5 -0.9 -1.9 -0.3 -0.3 0.4 0.2
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 3.1 0.2 1.3 1.7 0.6 1.8 0.5
Qualifications: None of the above 0.2 0.4 1.3 -0.2 0.2 -1.2 -0.2 0.9 -0.4
Financial difficulties in last 2 years 0.6 0.9 1.6 0.2 0.5 -1.2 1.0 1.3 0.8
Mouth/teeth dental problems 1.4 2.2 3.4 1.9 1.1 1.1 1.8 -1.3 -1.5
Heart attack 0.1 0.2 0.3 0.5 0.6 0.1 -0.3 0.4 0.4
Allergy 0.5 1.1 3.1 -0.3 -0.4 -0.7 0.0 -1.8 -1.7
Pain all over the body in last month 0.5 0.6 2.0 -0.3 0.2 -1.4 0.3 0.9 0.7
Diabetes (self-reported) 1.6 2.5 5.4 -1.5 -1.3 -1.8 -0.3 2.3 1.5
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 3.7 -0.9 -1.1 -1.1 -0.6 1.4 1.9
Medication: Ramipril 0.2 0.3 0.9 0.1 0.1 0.9 0.3 -0.9 -0.0
Medication: Simvastatin 1.2 1.8 6.8 -1.4 -0.4 0.2 -2.6 0.6 1.2
Fluid intelligence score 0.7 1.5 4.4 -0.8 -0.4 0.4 -1.9 0.6 2.1
Illnesses of siblings 0.3 0.5 1.2 1.1 0.8 -0.0 -0.6 -0.9 -0.2
Neuroticism score 0.5 1.0 3.0 -0.4 -0.4 -0.6 1.7 0.8 1.4
Weight 0.1 0.5 1.0 -1.0 -0.8 -0.4 -0.5 1.0 0.2
Impedance of arm (right) 0.3 1.2 2.2 -1.5 -1.5 -0.5 0.2 0.8 1.3
Arm fat percentage (right) 0.1 0.2 0.5 -0.5 0.0 -0.4 -0.2 0.7 -0.5
Trunk fat-free mass 0.0 0.2 0.7 -0.1 -0.4 0.1 -0.8 0.5 0.3
Hip circumference 0.1 0.3 0.8 -0.4 -0.1 -0.5 -0.7 0.9 0.5
Time employed in main current job 0.9 1.0 3.6 -0.2 -0.4 -0.8 -0.5 1.2 1.9
Alcohol intake versus 10 years previously 0.4 0.7 2.7 0.7 1.6 0.8 0.2 -0.1 -0.4
Father’s age at death 1.7 2.3 8.3 1.3 -0.3 0.7 0.3 -2.9 -1.9
Worrier / anxious feelings 1.0 1.8 4.2 1.2 2.1 1.2 1.4 1.1 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 4.3 -0.2 0.5 -0.5 -0.2 2.1 1.7
Falls in the last year 1.2 1.6 2.5 1.6 0.9 0.9 1.5 -1.3 -1.3
Hair/balding pattern: Pattern 3 0.9 1.3 3.6 1.6 1.9 0.8 0.2 -0.8 -0.4
Number of live births 0.8 1.1 4.2 0.6 0.2 -0.8 2.0 -0.5 -1.1
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 6.0 0.5 -0.7 -1.6 2.5 -0.6 -0.2
Pulse rate 0.7 1.2 2.9 -0.2 -1.1 -0.2 1.4 -1.7 -1.1
Happiness 0.3 0.4 1.3 0.3 0.1 -0.6 1.1 0.9 -0.1
Noisy workplace 1.2 1.4 3.4 -1.7 -1.2 0.5 -0.7 1.9 0.6
Qualifications: A levels/AS levels or equivalent 0.6 1.3 3.5 -0.7 -1.1 -0.3 -1.2 -1.9 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 3.2 -1.0 -0.3 0.3 -1.8 0.7 1.0
Mouth/teeth dental problems: Dentures 0.2 0.4 0.6 -0.7 -0.5 0.5 -0.8 -0.8 -0.1
Asthma 0.4 0.8 2.6 0.3 0.6 -0.3 -0.9 1.6 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.7 1.2 1.6 -0.2 0.2 0.5 0.1
Medication: Cholesterol lowering 0.3 0.5 1.3 -0.8 -1.2 0.1 -0.7 0.6 -0.0
Depression (self-reported) 1.1 1.3 6.9 0.2 -0.4 -0.9 2.6 -0.2 -0.2
Medication: Lansoprazole 0.4 0.5 1.9 -0.5 0.1 0.6 -1.4 0.3 0.6
Prospective memory result 1.1 1.4 3.8 0.1 -0.7 -0.6 1.5 -1.3 -1.9
Lung cancer (father) 0.5 0.6 1.4 0.7 0.6 0.2 1.0 -0.8 -1.2
Illnesses of mother 0.6 0.8 1.9 0.6 -0.3 -0.0 1.3 -1.4 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 3.5 0.4 -0.6 -0.9 1.9 -0.3 0.0
Pulse wave Arterial Stiffness index 1.8 2.1 4.7 1.4 0.9 2.2 0.0 -1.1 -2.0
Impedance of arm (left) 0.3 1.5 2.6 -1.6 -1.5 -0.6 0.4 1.2 1.6
Arm fat mass (right) 0.1 0.3 1.0 -0.6 -0.2 -0.3 -0.3 1.0 -0.4
Trunk predicted mass 0.0 0.2 0.8 -0.2 -0.4 0.1 -0.9 0.6 0.3
Standing height 0.2 2.1 5.5 -1.6 -2.4 -0.5 -0.6 1.2 1.6
Length of working week for main job 2.1 2.3 4.3 1.4 2.1 0.5 1.1 -1.5 -2.1
Exposure to tobacco smoke at home 0.3 0.4 0.9 0.0 -0.2 0.5 0.9 0.9 -0.5
Breastfed as a baby 0.9 1.1 5.1 -0.4 -0.4 2.3 -1.1 -0.3 0.3
Tense / ‘highly strung’ 0.4 0.6 2.4 0.5 0.7 1.6 0.7 -0.1 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 3.3 -0.2 0.6 1.2 0.8 1.8 1.7
Hair/balding pattern: Pattern 4 0.5 1.2 6.4 -0.4 -0.1 -0.4 -0.4 2.5 0.5
Birth weight of first child 2.1 3.8 5.9 -2.1 -1.5 -1.8 -1.5 2.2 2.4
Peak expiratory flow (PEF) 1.2 2.7 8.2 -1.1 -1.9 -2.9 1.7 0.3 0.7
Pulse wave reflection index 0.7 0.9 3.2 0.6 0.1 1.8 -1.0 0.7 -0.0
Ever highly irritable/argumentative for 2 days 5.7 6.8 18.6 -2.7 -2.1 -1.4 0.1 4.3 3.0
Loud music exposure frequency 0.2 0.3 0.8 -0.2 -0.8 -0.1 -0.9 -0.0 -0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.6 0.5 0.0 0.3 0.2 -0.1 0.8
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 2.8 -1.7 -1.2 -1.2 -1.0 0.9 1.0
Blood clot in the leg (DVT) 0.7 0.9 2.4 0.3 0.1 1.6 1.4 0.9 -0.2
Medication: Paracetamol 0.6 1.0 2.8 0.2 0.1 -1.4 1.7 0.6 0.9
Headache pain in last month 0.6 1.1 3.0 1.0 1.7 -0.5 1.4 0.4 -0.3
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.5 0.3 0.7 -0.1 0.2 -0.7 -0.3
Glaucoma (self-reported) 1.1 1.3 5.9 -0.8 -0.0 0.7 -0.5 2.4 0.7
Gout (self-reported) 0.1 0.2 0.5 0.3 -0.3 -0.7 0.6 0.1 0.1
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 3.4 0.3 -1.0 -1.9 0.6 -1.8 -0.7
Medication: Amlodipine 0.2 0.2 0.5 -0.5 -0.5 -0.4 0.2 0.7 0.3
Medication: Ventolin 100micrograms inhaler 1.0 1.3 4.9 -0.3 -0.4 -1.1 -0.1 2.2 1.3
Birth weight 2.2 4.8 9.1 -2.6 -2.7 -0.5 -1.8 1.5 3.0
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.3 -0.7 -0.3 1.1 0.0 0.8 0.1
High blood pressure (siblings) 0.8 1.1 4.6 -0.4 -1.0 -0.6 2.1 0.2 -0.7
Forced vital capacity (FVC), Best measure 0.2 0.6 2.8 0.5 -0.4 -0.5 1.7 0.0 0.6
Body fat percentage 0.2 0.6 1.6 -1.3 -0.5 -0.7 -0.0 1.1 -0.3
Leg fat percentage (right) 0.2 0.6 2.2 -1.5 -0.1 0.0 -0.1 1.0 -0.7
Arm fat-free mass (right) 0.0 0.1 0.3 -0.3 -0.3 -0.5 -0.5 0.5 -0.0
Exposure to tobacco smoke outside home 0.7 1.0 2.6 -0.7 -0.5 -1.1 -1.6 0.8 0.8
Comparative body size at age 10 0.4 1.2 2.4 0.7 0.0 -1.6 1.2 -1.2 -1.1
Number of full brothers 1.1 1.4 4.0 -0.7 -0.1 2.0 -2.0 0.4 0.3
Worry too long after embarrassment 0.5 0.9 3.5 -1.0 -0.8 -0.2 0.1 0.5 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 3.1 -0.3 0.2 1.7 1.6 0.5 -0.5
Wheeze or whistling in the chest in last year 1.2 2.1 4.5 1.4 2.1 1.4 -1.7 1.1 -0.2
Number of children fathered 0.4 0.4 0.8 -0.7 -0.0 -0.8 -0.9 0.3 0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.6 -1.2 -1.3 -0.9 0.0 1.0 1.9
Age at first live birth 0.4 0.7 3.6 -0.2 0.1 0.6 -1.9 -0.0 0.4
Pulse wave peak to peak time 1.8 2.1 4.4 -1.5 -1.0 -2.0 -0.0 1.1 2.1
Health satisfaction 1.0 1.3 3.0 -1.2 -0.8 0.8 -0.6 1.7 1.2
Shortness of breath walking on level ground 1.0 1.2 3.5 -0.7 -0.0 -0.0 -0.8 1.6 1.9
Qualifications: College or University degree 0.2 0.7 2.0 0.3 -0.8 1.4 0.0 -1.2 -0.1
Eye problems/disorders: None of the above 0.2 0.2 0.6 0.4 0.2 -0.6 -0.7 -0.5 0.2
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.0 1.4 0.8 -0.9 0.6 -0.2 -0.7
Emphysema/chronic bronchitis 1.0 1.1 3.0 -1.7 -1.3 0.6 -0.2 0.5 1.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.6 -0.8 -0.5 0.6 -0.1 0.1 -0.5
Neck or shoulder pain in last month 0.6 0.8 2.9 1.0 1.7 -0.1 0.9 0.2 -0.4
Medication: Blood pressure 0.2 0.3 0.7 -0.6 -0.8 0.1 -0.1 0.8 0.5
Angina (self-reported) 0.2 0.3 1.2 0.5 0.1 1.1 -0.2 -0.2 0.1
Migraine (self-reported) 0.7 0.9 1.6 0.6 1.2 1.3 1.1 0.9 -0.1
Medication: Ibuprofen 0.9 1.0 4.2 1.4 2.1 -0.0 -0.1 0.3 -0.0
Medication: Allopurinol 1.2 1.6 3.1 -1.3 -1.6 -0.3 0.0 1.5 1.8
Medication: Omeprazole 1.6 1.9 6.4 0.4 -0.2 -1.0 0.8 -2.5 -1.8
Medication: Seretide 50 evohaler 0.2 0.3 1.0 0.6 0.5 -0.2 1.0 -0.2 -0.1
Mean time to correctly identify matches 0.3 0.5 1.8 1.0 0.5 -0.2 0.3 -0.1 -1.4
Heart disease (mother) 0.4 0.5 1.7 -0.8 0.3 0.7 -0.3 0.5 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 3.7 -1.9 -1.8 -0.6 -0.0 0.2 1.9
Whole body fat mass 0.1 0.4 0.9 -1.0 -0.4 -0.6 -0.3 1.0 -0.2
Leg fat mass (right) 0.1 0.5 1.4 -1.2 -0.2 -0.2 -0.4 0.9 -0.6
Arm predicted mass (right) 0.1 0.3 0.5 -0.4 -0.3 -0.7 -0.7 0.7 0.2
Pulse rate, automated reading 0.6 2.0 4.5 -0.3 -1.7 -1.1 1.3 -2.1 -1.2
Alcohol intake frequency. 1.6 3.7 5.7 1.9 2.2 0.7 2.3 -1.5 -2.4
Comparative height size at age 10 0.0 0.2 0.5 0.1 -0.7 -0.5 0.2 -0.4 -0.1
Number of full sisters 1.4 1.7 3.2 -1.8 -1.4 -1.7 0.1 1.1 1.1
Suffer from ‘nerves’ 1.4 2.3 7.1 1.6 1.8 -0.7 2.7 -0.3 -0.0
Overall health rating 0.4 0.9 2.4 -1.5 -0.6 0.1 -1.3 0.4 0.9
Chest pain or discomfort 1.1 1.6 4.5 -1.3 -0.7 0.4 -2.1 0.7 1.6
Had major operations 1.3 1.5 3.9 -1.1 -0.5 0.4 -1.4 2.0 1.2
Age at last live birth 0.1 0.2 0.7 -0.1 0.1 -0.1 -0.9 -0.2 0.3
Family relationship satisfaction 1.2 1.5 3.6 1.6 1.9 0.8 1.4 0.1 -0.3
Leg pain on walking 1.5 1.9 4.0 1.4 2.0 1.5 -0.9 -0.9 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.0 4.9 0.2 -0.1 -1.1 2.2 0.2 -0.3
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.5 -0.6 -0.7 0.2 1.2 -0.5 -0.8
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 3.4 -0.5 -1.8 0.7 0.5 -0.8 -0.5
Medication: Aspirin 0.3 0.5 1.7 0.4 -0.3 -0.5 -0.5 -1.3 -0.5
Supplements: Vitamin C 0.2 0.3 0.8 0.2 0.9 0.1 -0.2 0.6 0.6
Knee pain experienced in last month 0.5 0.8 1.6 0.7 0.4 0.6 -1.1 -1.3 -0.9
Hypertension (Self-reported) 0.4 1.0 3.6 -1.2 -1.9 -0.2 -0.2 0.3 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 7.4 -0.1 -0.6 0.1 -0.7 -2.7 -0.9
Illnesses of father: Heart disease 0.7 0.9 3.7 -0.0 -1.3 -0.2 1.9 0.1 -0.5
Illnesses of siblings: Diabetes 2.3 2.8 5.3 -2.3 -2.0 -0.5 -1.0 1.1 2.3
Smoking status: Previous 0.8 1.2 2.4 -1.3 -0.7 0.5 -0.2 1.6 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 2.2 -0.2 -1.1 -1.5 0.5 -0.7 0.1
Whole body fat-free mass 0.0 0.2 0.8 -0.1 -0.4 -0.4 -0.9 0.4 0.4
Leg fat-free mass (right) 0.0 0.2 0.6 0.3 -0.2 -0.7 -0.8 -0.2 0.1
Arm fat percentage (left) 0.1 0.4 1.2 -0.8 -0.2 -0.6 -0.1 1.1 -0.1
Average weekly red wine intake 0.8 1.1 2.2 1.5 0.4 1.3 -1.1 -1.2 -0.3
Handedness (chirality/laterality): Left-handed 0.8 0.9 3.7 -0.4 -0.8 1.9 0.2 -0.7 -0.6
Mood swings 1.0 1.9 5.4 0.0 0.3 -1.7 2.3 1.3 1.2
Loneliness, isolation 0.4 0.6 1.6 0.2 0.4 -0.9 0.7 0.5 1.3
Long-standing illness, disability or infirmity 0.4 0.7 1.6 -0.3 0.7 -1.0 0.5 1.3 0.8
Ever had bowel cancer screening 0.5 0.5 1.4 0.6 0.5 0.6 -1.2 0.8 0.4
Diabetes diagnosed by doctor 1.7 2.9 4.4 -1.5 -1.9 -2.1 0.2 2.1 1.6
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 5.4 0.2 -0.6 -2.3 0.7 -0.1 0.0
Friendships satisfaction 0.1 0.1 0.4 -0.6 -0.4 0.4 0.0 -0.2 -0.2
Qualifications: nursing, teaching 0.6 0.9 3.0 0.6 0.1 1.7 -0.4 -0.8 -1.2
Commuting to job workplace: Walk 2.8 3.1 7.3 -0.6 -0.3 -2.7 -2.4 1.4 1.7
Eye problems/disorders: Cataract 0.4 0.5 1.3 -0.5 0.3 0.8 -0.1 1.1 0.8
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.1 -0.4 0.0 -0.3 0.0 0.2 0.3
Medication for cholesterol 0.4 0.6 1.5 -0.4 -0.0 1.2 0.6 1.2 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.6 0.5 0.6 -1.3 1.2 -0.8 -0.7
Back pain experienced in last month 0.1 0.1 0.7 -0.3 -0.1 0.0 0.8 0.0 -0.0
Mineral and other dietary supplements 0.3 0.4 1.0 0.1 0.4 -0.8 1.0 0.3 -0.5
Breast cancer (self-reported) 0.2 0.3 0.7 0.0 -0.3 -0.1 -0.6 0.8 0.8
Asthma (self-reported) 0.4 0.8 2.1 0.4 0.7 0.1 -0.9 1.4 1.0
Osteoporosis (self-reported) 0.8 1.0 2.2 0.2 1.4 0.6 1.5 1.2 0.2
Osteoarthritis (self-reported) 0.2 0.3 0.8 0.2 0.2 0.4 -0.9 -0.5 -0.7
Medication: Aspirin 0.5 0.6 2.5 0.5 -0.2 -0.4 -0.2 -1.6 -0.9
Medication: Gliclazide 2.5 2.8 5.0 -1.4 -1.7 -2.2 0.2 1.9 1.8
Illnesses of father: None of the above (group 1) 0.9 1.1 2.9 0.3 0.6 0.5 -1.4 -1.7 -0.8
Smoking status: Current 1.0 1.6 4.3 -1.2 -1.0 -1.1 -0.4 1.1 2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.8 -0.0 -0.6 0.0 -0.1 -0.4 -0.9
Whole body water mass 0.0 0.2 0.5 -0.1 -0.5 -0.5 -0.7 0.4 0.3
Leg predicted mass (right) 0.0 0.2 0.6 0.3 -0.1 -0.7 -0.7 -0.2 0.1
Arm fat mass (left) 0.1 0.4 1.5 -0.8 -0.2 -0.5 -0.2 1.2 -0.1
Number of self-reported non-cancer illnesses 0.7 1.2 3.1 0.0 0.1 1.8 -1.1 0.9 1.3
Average weekly champagne plus white wine intake 0.3 0.5 1.3 -0.3 -1.0 -1.1 -0.2 -0.1 0.6
Miserableness 1.1 1.9 6.0 -1.0 -0.5 -0.6 0.5 1.9 2.4
Guilty feelings 0.6 0.9 3.9 -0.3 -0.4 -1.1 0.0 0.5 2.0
Wears glasses or contact lenses 1.0 1.2 4.3 1.2 0.8 0.4 2.1 0.6 -0.3
Ever taken oral contraceptive pill 1.6 1.8 5.9 0.6 0.7 -0.9 -2.4 0.8 1.6
Hearing aid user 0.7 0.7 2.0 -0.9 -0.7 1.4 0.9 0.1 0.4
Mother’s age at death 1.2 1.5 4.7 -0.3 -0.1 0.4 -2.2 1.3 1.4
Financial situation satisfaction 0.7 0.9 3.1 -0.6 -0.6 0.8 1.8 1.0 0.3
Tinnitus: Yes, now most or all of the time 1.9 2.3 8.4 -0.1 0.2 -2.9 -0.8 1.3 1.7
Commuting to job workplace: Public transport 0.6 0.8 1.6 -0.5 -1.3 -1.0 0.6 0.9 0.6
Eye problems/disorders: Glaucoma 1.0 1.1 2.1 -1.3 -0.7 1.3 -0.8 1.4 0.4
Medication: Blood pressure 0.5 0.9 1.6 -0.7 -1.1 -1.1 -0.4 -0.7 1.3
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 -0.4 0.3 -0.9 -0.4 0.5 0.4
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.9 0.3 -0.1 0.3 -1.0 -0.8 0.2
High cholesterol (Self-reported) 0.4 0.7 1.9 0.6 0.5 0.9 -0.2 -1.4 -0.9
Medication: Bendroflumethiazide 0.3 0.5 2.1 0.2 0.1 0.0 -0.6 -1.4 -0.5
Medication: Paracetamol 0.8 1.2 4.8 -0.1 -0.3 -1.4 2.2 0.5 0.6
Medication: Lisinopril 0.2 0.2 0.5 -0.2 -0.6 -0.7 0.2 -0.6 0.3
Medication: Atorvastatin 1.4 1.7 2.3 1.5 0.8 -1.4 1.4 -1.0 -1.5
Illnesses of father: High blood pressure 1.4 1.7 4.3 -0.7 -0.5 -1.2 0.8 2.1 1.7
Alcohol drinker status: Never 0.7 0.8 2.7 0.1 -0.4 -1.4 1.6 0.2 0.1
Ever smoked 1.1 1.9 5.3 -1.4 -0.5 0.4 -1.0 1.7 2.3
Basal metabolic rate 0.0 0.2 0.4 -0.3 -0.5 -0.7 -0.6 0.5 0.2
Leg fat percentage (left) 0.1 0.5 1.5 -1.2 0.1 -0.0 -0.3 0.9 -0.7
Arm fat-free mass (left) 0.0 0.1 0.3 -0.1 -0.1 -0.3 -0.6 0.3 -0.2
Number of operations (self-reported) 1.4 2.1 5.7 -0.1 0.5 0.3 -2.4 1.8 1.8
Average weekly beer plus cider intake 1.7 2.5 5.3 -1.4 -1.6 -2.3 -0.6 1.6 1.4
Irritability 0.1 0.2 0.8 0.1 -0.5 0.1 -0.1 0.4 0.9
Risk taking 0.2 0.3 1.7 -0.2 -0.4 1.3 -0.1 0.5 0.1
Ever had prostate specific antigen (PSA) test 1.1 1.3 4.4 2.1 1.1 0.4 1.2 -0.3 -0.8
Fractured/broken bones in last 5 years 0.8 1.0 2.5 -0.8 -1.2 -0.0 -1.2 0.2 1.6
Age started oral contraceptive pill 1.0 1.3 2.8 1.5 1.0 -0.7 0.6 -1.7 -0.8
Diastolic blood pressure, automated reading 1.3 4.0 9.6 0.5 -0.2 3.1 1.3 -2.4 -2.6
Ever depressed for a whole week 1.9 2.3 6.9 0.9 2.0 2.6 -0.5 1.3 0.2
Unable to work because of sickness or disability 1.2 1.6 5.8 -1.1 -0.8 -0.3 0.4 2.4 1.2
Commuting to job workplace: Cycle 0.2 0.2 1.2 -0.0 -0.2 -1.1 -0.4 0.3 -0.1
Myopia 0.6 0.9 2.2 -0.9 -0.6 -0.5 0.1 1.5 1.4
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.9 0.7 1.4 -0.0 0.3 -0.0 -0.7
Cholesterol lowering medication 0.2 0.3 1.0 0.3 0.8 -0.1 -0.5 -1.0 -0.3
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 3.6 -0.4 -1.1 -1.9 0.8 -1.9 -1.1
Pain experienced in last month 0.6 1.0 3.6 -1.0 -1.9 -0.3 -1.0 -0.2 0.5
Supplements: Calcium 0.2 0.2 0.5 -0.5 -0.4 0.3 0.6 -0.1 0.7
Basal cell carcinoma (self-reported) 1.3 1.5 3.7 1.9 1.1 1.2 0.6 -0.8 -1.3
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.5 0.2 0.4 -0.2 -0.5 0.7 0.6
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.9 0.5 0.3 2.0 0.9 0.6 -0.3
Heart disease (siblings) 1.4 1.7 3.6 -1.4 -0.8 -0.0 -1.9 0.9 1.9
Alcohol drinker status: Previous 0.6 0.6 1.8 0.6 -0.1 -1.2 1.4 0.1 -0.3
Pack years of smoking 0.4 0.6 2.6 -0.2 1.0 0.1 -0.2 1.6 -0.3
Impedance of whole body 0.2 1.3 3.6 -1.9 -1.4 -0.4 0.6 0.9 0.9
Leg fat mass (left) 0.1 0.4 1.2 -1.1 -0.2 -0.2 -0.5 0.9 -0.5
Arm predicted mass (left) 0.0 0.1 0.2 -0.2 -0.3 -0.4 -0.4 0.4 -0.1