Hub : Genes

FOXK2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.3510	0.1010	6.5e-04	-0.006	NA	0.044	NA	0.038	4.8e-01	NA	3.4e-02	NA	4.6e-02
2	GTEx	Cells Transformed fibroblasts	0.1460	0.0580	8.8e-03	-0.002	NA	0.001	NA	0.002	4.7e-01	NA	2.6e-01	NA	2.3e-01
3	YFS	Blood	0.0537	0.0196	9.7e-05	0.022	0.008	0.013	0.017	0.017	5.1e-08	0.00093	3.9e-05	2.2e-06	1.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	1.5	-1.2	-0.1	0.6
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.2	-0.7	0.3
Depressed Affect (Nagel 2018)	2.5	5.2	10.2	-0.3	-3.2	2.3
Depression (Nagel 2018)	1.7	2.6	6.0	1.1	-2.5	0.8
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	0.5	-0.9	0.2
Neuroticism (Nagel 2018)	0.6	1.4	2.0	1.4	-1.4	0.5
Schizophrenia (2018)	0.2	0.4	0.6	0.7	-0.8	-0.0
Schizophrenia vs Biploar Disorder	0.5	0.7	1.8	1.3	-0.1	-0.6
Worry (Nagel 2018)	0.7	1.5	4.5	2.1	-0.3	-0.2
Alzheimer’s Disease (in mother)	4.8	5.7	7.1	-2.5	-2.7	1.9
Alzheimer’s Disease (in father)	1.5	1.6	1.8	-1.4	1.2	-1.3
Alzheimer’s Disease (including proxy)	2.4	3.5	8.2	-2.9	-1.4	0.6
Crohns Disease (2017)	1.0	2.1	2.7	1.6	-1.0	1.7
Irritable Bowel Disease (IBD)	1.1	2.6	7.2	2.7	-0.0	0.7
Ulcerative Colitis (UC)	1.8	3.4	9.5	3.1	0.8	-0.5
Major Depression (MDD)	0.6	0.8	1.0	1.0	-1.0	-0.6
Reaction Time	1.2	2.4	3.6	-1.0	1.9	-1.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.3	1.1	-0.2	-0.3
Breast Cancer	3.4	8.3	11.6	-1.6	3.4	-3.3
Ovarian Cancer	0.7	1.0	2.1	0.4	1.4	-0.8
Prostate Cancer	1.2	1.7	3.8	-1.9	0.5	-1.0
Age at First Birth	0.1	0.2	0.6	-0.7	-0.1	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.8	2.5	7.4	-2.7	-0.2	0.3
Coronary Artery Disease (CAD)	0.4	0.4	1.0	0.5	0.0	1.0
Crohns Disease (2012)	0.3	0.4	1.3	1.1	0.1	0.1
Mean Putamen Volume	0.3	0.3	0.8	-0.4	-0.0	-0.9
Fasting Glucose	1.0	1.2	2.4	1.6	-1.0	0.6
HbA1C	3.8	4.2	12.1	-3.5	0.3	-0.5
HDL Cholesterol	1.4	2.4	2.9	-1.7	1.3	-1.7
LDL Cholesterol	1.2	1.9	4.0	-2.0	0.9	-1.0
Lupus	0.8	1.2	2.1	1.4	-1.2	0.1
Neuroticism (2016)	0.5	0.7	1.4	1.2	-0.9	0.1
Primary Biliary Cirrhosis	0.5	0.8	1.9	1.4	0.6	-0.0
Rheumatoid Arthritis	0.2	0.3	0.6	0.7	0.1	0.6
Schizophrenia (2014)	0.3	0.7	1.1	0.7	-1.1	0.8
Triglycerides	1.2	2.0	4.9	-2.2	-0.6	0.9
Type 2 Diabetes (T2D) (2012)	0.8	1.0	2.2	-0.8	1.5	-0.4
Ulcerative Colitis	2.3	3.4	9.3	3.0	0.6	-0.7
Blood Eosinophil Count	0.5	3.8	4.8	-1.5	-2.2	2.1
Blood Platelet Count	0.6	6.9	18.3	-4.3	0.7	-1.4
Blood Red Count	0.6	5.4	15.8	4.0	-0.3	0.5
Blood White Count	0.1	0.6	1.2	-1.1	0.6	-0.4
Heel T-Score	0.2	1.6	2.1	1.5	-1.0	1.3
BMI	0.3	1.7	4.7	-2.2	0.5	-0.3
Height	0.6	11.7	34.6	5.9	0.5	0.4
Waist Hip Ratio (WHR)	0.1	0.2	0.7	-0.1	0.8	0.2
Systolic Blood Pressure	0.4	2.1	3.6	-1.3	-1.0	1.9
Smoking Status	0.5	1.2	2.0	-1.4	-0.3	1.2
Allergy or Eczema	0.1	0.2	0.5	-0.3	-0.7	0.2
Cardiovascular Disease	0.3	1.0	1.9	-1.4	-0.7	0.7
Hypothyroidism (self reported)	0.1	0.2	0.5	-0.3	0.2	0.7
Respiratory disease	0.8	1.7	3.7	-1.9	-0.6	1.1
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.0	0.5	-1.7	0.6
Lung FEV1/FVC ratio	0.5	2.6	3.7	-0.6	-1.9	1.9
Lung FVC	0.7	3.6	6.1	2.5	-2.0	0.8
Neuroticism	0.4	0.9	2.2	0.0	-1.5	0.6
Chronotype (morning person)	0.3	0.7	1.2	0.5	0.8	-1.1
Hair Pigment	0.4	10.4	24.0	-4.9	1.1	-2.4
Tanning	0.0	0.4	0.8	0.4	0.9	-0.6
Hand grip strength (left)	0.4	1.1	2.3	0.2	0.9	1.5
Number of treatments/medications taken	1.0	1.8	3.0	-1.7	-1.4	0.6
Average weekly spirits intake	0.2	0.2	0.6	0.8	0.3	-0.2
Sensitivity / hurt feelings	1.1	1.8	2.5	1.1	1.4	-1.6
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.0	1.3	-1.4	0.2
Hearing difficulty/problems: Yes	1.6	2.5	3.5	0.9	-1.9	1.8
Relative age of first facial hair	0.7	1.4	3.5	-1.9	-0.0	-0.8
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	-0.2	-0.6	-0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.1	-0.3	-0.5
Ever had hysterectomy (womb removed)	5.9	6.6	11.2	-0.7	2.9	-3.3
Systolic blood pressure, automated reading	0.3	0.8	1.3	-1.1	-0.8	0.8
Eye problems/disorders: Diabetes related eye disease	3.0	3.3	4.9	0.9	-2.2	2.0
Angina	0.1	0.2	0.3	-0.5	-0.2	0.4
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.5	0.2	-0.0
Vitamin and mineral supplements	0.4	0.5	1.1	-0.4	1.1	-0.5
Supplements: Zinc	0.0	0.0	0.0	0.0	-0.0	0.1
Medication: Co-codamol	1.1	1.2	2.1	-1.1	-1.5	0.6
Medication: Metformin	0.4	0.5	1.3	-0.4	-1.2	0.0
Diabetes (father)	1.6	1.9	3.8	1.1	1.9	-0.9
Diabetes (mother)	0.5	0.6	1.3	1.1	-0.6	0.4
Severe depression (siblings)	1.3	1.4	1.9	1.3	-1.4	0.8
Pack years adult smoking proportion	0.0	0.1	0.1	-0.0	-0.3	-0.4
Impedance of leg (right)	0.1	0.6	1.6	1.3	-0.2	-0.3
Leg fat-free mass (left)	0.1	0.3	0.4	0.6	0.5	-0.5
Trunk fat percentage	0.1	0.6	1.1	0.7	0.1	-1.1
Hand grip strength (right)	0.9	2.5	7.3	-0.3	-0.1	2.7
Townsend deprivation index at recruitment	0.3	0.4	0.8	0.6	0.4	-0.9
Current tobacco smoking	0.1	0.2	0.5	-0.7	0.1	-0.0
Average weekly fortified wine intake	0.2	0.3	0.5	-0.4	0.7	-0.3
Maternal smoking around birth	0.9	1.3	2.7	0.3	-1.6	1.1
Fed-up feelings	1.4	2.5	5.0	-0.9	-2.2	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	5.8	0.5	-2.4	0.8
Relative age voice broke	0.4	0.7	1.6	-1.3	-0.1	-0.6
Taking other prescription medications	1.1	1.7	3.6	-1.9	-1.1	0.6
Age when periods started (menarche)	0.3	0.6	1.5	1.2	-0.1	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.5	-0.4	0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	1.5	-1.2	-0.8	1.2
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.1	1.0	1.0	-0.2
Qualifications: CSEs or equivalent	1.1	1.5	2.5	0.2	1.4	-1.6
Serious illness, injury or assault to yourself	0.4	0.5	1.5	0.2	0.2	-1.2
High blood pressure	0.5	1.4	3.6	-1.9	-0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	-0.7	0.2	-0.8
Multivitamins +/- minerals	0.1	0.1	0.3	0.1	0.5	0.1
Stomach or abdominal pain in last month	0.4	0.5	1.4	-1.2	0.1	-0.1
Supplements: Glucosamine	1.5	1.9	3.1	0.6	-1.6	1.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	-0.9	-0.4	0.1
Medication: Atenolol	4.0	5.0	9.3	-1.2	3.0	-2.1
Medication: Levothyroxine sodium	0.2	0.3	0.5	0.7	0.2	0.6
Sitting height	0.2	1.6	4.6	2.1	0.2	-0.2
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.4	-0.4	0.8
High blood pressure (mother)	0.1	0.1	0.3	-0.5	-0.3	0.2
Body mass index (BMI)	0.0	0.2	0.2	-0.5	-0.1	-0.5
Impedance of leg (left)	0.1	0.4	0.9	1.0	-0.4	-0.2
Leg predicted mass (left)	0.0	0.2	0.3	0.5	0.4	-0.4
Trunk fat mass	0.1	0.5	0.9	0.9	0.1	-0.7
Waist circumference	0.1	0.2	0.4	0.1	0.5	-0.6
Number of incorrect matches in round	2.0	3.3	6.6	-0.1	1.8	-2.6
Past tobacco smoking	0.8	1.5	4.0	2.0	0.4	-0.6
Alcohol usually taken with meals	0.5	0.8	2.2	-0.5	-0.2	1.5
Nervous feelings	2.1	4.0	6.8	2.6	1.4	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	-0.0	-0.6	-0.2
Hearing difficulty/problems with background noise	0.7	1.1	2.4	-0.1	-1.5	0.9
Hair/balding pattern: Pattern 2	1.0	1.3	3.2	-0.2	-1.8	0.7
Had menopause	0.4	0.5	1.2	0.3	0.5	-1.1
Had other major operations	0.4	0.5	0.8	0.7	-0.9	-0.5
Forced vital capacity (FVC)	1.2	4.6	8.4	2.9	-1.5	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.4	-0.8	-0.4	1.2
Ever unenthusiastic/disinterested for a whole week	1.8	2.1	4.7	-2.2	-0.9	0.9
Qualifications: None of the above	0.4	0.9	2.6	0.3	-0.0	-1.6
Financial difficulties in last 2 years	0.1	0.2	0.5	0.2	-0.1	-0.7
Mouth/teeth dental problems	0.4	0.6	1.3	0.0	1.2	-0.6
Heart attack	2.6	3.4	5.2	-1.0	-2.0	2.3
Allergy	0.1	0.2	0.4	0.6	-0.2	0.5
Pain all over the body in last month	1.3	1.4	2.3	-1.3	-1.5	0.5
Diabetes (self-reported)	0.1	0.2	0.3	0.4	-0.5	-0.5
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	1.3	0.7	1.2	-1.1
Medication: Ramipril	1.5	1.9	3.2	-0.6	1.5	-1.8
Medication: Simvastatin	0.9	1.3	2.2	-1.5	0.6	-1.2
Fluid intelligence score	0.4	0.7	1.6	1.3	0.5	-0.6
Illnesses of siblings	0.4	0.6	1.6	-1.3	0.2	0.3
Neuroticism score	0.3	0.6	1.3	0.8	-1.1	0.1
Weight	0.1	0.4	0.9	1.0	0.1	-0.5
Impedance of arm (right)	0.1	0.5	1.2	1.1	-0.1	-0.5
Arm fat percentage (right)	0.0	0.1	0.3	0.0	-0.2	-0.6
Trunk fat-free mass	0.1	0.4	0.6	0.8	-0.1	0.8
Hip circumference	0.2	0.7	1.5	1.2	0.0	-0.8
Time employed in main current job	1.6	1.9	4.9	2.2	-0.8	-0.2
Alcohol intake versus 10 years previously	0.3	0.5	0.9	-0.9	-0.7	0.4
Father’s age at death	0.7	0.9	1.6	1.3	0.0	1.1
Worrier / anxious feelings	0.3	0.6	1.1	0.8	0.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.5	7.7	0.7	-2.8	1.5
Falls in the last year	2.0	2.7	6.1	-1.2	-2.5	0.7
Hair/balding pattern: Pattern 3	2.4	3.6	6.3	1.0	2.5	-1.8
Number of live births	1.0	1.4	1.9	0.8	1.4	-1.3
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	5.5	2.3	-1.9	2.2
Pulse rate	0.8	1.3	2.2	-0.0	-1.3	1.5
Happiness	0.7	0.8	2.3	-0.2	-1.5	0.4
Noisy workplace	0.7	0.8	1.7	1.3	-0.3	0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.7	2.7	-0.8	-1.3	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.9	0.7	1.4	0.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	0.3	0.4	-1.4
Asthma	0.4	0.8	1.3	-1.1	-0.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.9	0.6	-1.0	0.2
Medication: Cholesterol lowering	0.7	1.0	1.3	-1.1	-0.7	1.1
Depression (self-reported)	0.8	0.9	2.1	-0.4	-1.5	0.7
Medication: Lansoprazole	0.4	0.4	0.6	-0.8	0.6	-0.6
Prospective memory result	0.7	0.9	2.2	0.3	0.5	-1.5
Lung cancer (father)	0.5	0.6	1.0	-0.8	0.2	-1.0
Illnesses of mother	1.9	2.3	3.3	1.0	1.8	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	6.4	2.5	-1.0	1.6
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	-0.2	-0.7	-0.5
Impedance of arm (left)	0.2	0.7	1.9	1.4	0.2	-0.5
Arm fat mass (right)	0.0	0.1	0.4	0.2	-0.0	-0.6
Trunk predicted mass	0.1	0.4	0.6	0.7	-0.2	0.8
Standing height	0.4	3.6	10.6	3.3	0.2	0.3
Length of working week for main job	0.6	0.7	1.9	-1.4	0.4	-0.1
Exposure to tobacco smoke at home	2.3	2.6	6.2	1.1	-2.5	0.6
Breastfed as a baby	0.4	0.5	0.8	0.9	-0.8	-0.1
Tense / ‘highly strung’	0.0	0.1	0.2	0.4	0.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	4.0	-0.4	-2.0	0.8
Hair/balding pattern: Pattern 4	0.9	2.2	3.5	1.9	-0.5	1.6
Birth weight of first child	1.5	2.7	8.0	2.8	-0.2	0.0
Peak expiratory flow (PEF)	1.0	2.4	4.5	1.0	-1.4	2.1
Pulse wave reflection index	0.1	0.1	0.4	-0.7	0.0	0.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	-0.3	0.2	-1.0
Loud music exposure frequency	1.0	1.1	1.7	0.0	1.3	-1.2
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.3	-0.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.7	0.3	-0.8	0.8
Blood clot in the leg (DVT)	0.4	0.6	0.8	-0.9	-0.8	-0.5
Medication: Paracetamol	0.2	0.4	0.5	0.3	0.7	-0.7
Headache pain in last month	1.7	2.8	3.8	-1.7	-1.4	1.9
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	6.6	2.6	1.0	-1.3
Glaucoma (self-reported)	0.7	0.8	1.4	-0.2	-1.2	-1.0
Gout (self-reported)	1.0	1.3	2.5	-1.6	1.1	-0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	0.6	0.0	1.0
Medication: Amlodipine	0.5	0.7	1.3	-0.8	1.2	-0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	-0.1	0.7	0.3
Birth weight	0.5	1.2	1.6	0.7	-1.2	1.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.0	0.4	-0.1	-1.0
High blood pressure (siblings)	0.3	0.4	0.6	0.5	0.5	-0.8
Forced vital capacity (FVC), Best measure	1.0	3.7	10.8	3.3	-0.3	0.6
Body fat percentage	0.1	0.3	0.6	0.4	-0.0	-0.8
Leg fat percentage (right)	0.0	0.1	0.3	0.2	-0.3	-0.5
Arm fat-free mass (right)	0.0	0.2	0.5	0.7	0.0	0.1
Exposure to tobacco smoke outside home	0.0	0.0	0.0	-0.0	0.1	0.0
Comparative body size at age 10	0.1	0.3	0.8	-0.9	0.0	-0.2
Number of full brothers	1.7	2.1	4.0	1.3	0.7	-2.0
Worry too long after embarrassment	0.3	0.5	1.0	1.0	-0.0	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.1	0.5	-1.8	0.3
Wheeze or whistling in the chest in last year	0.3	0.5	1.1	-0.4	0.2	-1.1
Number of children fathered	0.3	0.3	0.7	-0.2	-0.4	0.9
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.2	5.8	-0.4	-2.4	2.0
Age at first live birth	0.8	1.5	2.5	-1.0	-1.6	1.0
Pulse wave peak to peak time	0.3	0.3	0.8	0.3	0.9	0.3
Health satisfaction	2.3	3.0	4.4	-1.8	-2.1	1.2
Shortness of breath walking on level ground	0.7	0.9	1.5	1.2	0.8	-0.7
Qualifications: College or University degree	0.7	2.1	3.2	-1.6	-0.7	1.8
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.2	-0.3	-0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.0	-0.9	0.0	-1.0
Emphysema/chronic bronchitis	2.2	2.5	4.9	-0.8	-2.2	1.4
Medication for pain relief, constipation, heartburn	0.0	0.1	0.2	0.0	0.5	-0.1
Neck or shoulder pain in last month	0.4	0.6	1.7	0.0	-1.3	0.3
Medication: Blood pressure	2.2	3.8	8.1	-2.9	-0.7	1.7
Angina (self-reported)	0.0	0.0	0.1	-0.3	0.1	0.2
Migraine (self-reported)	7.0	8.7	17.6	0.2	-4.2	2.9
Medication: Ibuprofen	0.5	0.6	1.2	0.7	-1.1	0.5
Medication: Allopurinol	2.3	3.0	5.3	-1.5	2.3	-1.2
Medication: Omeprazole	1.1	1.3	2.4	-1.5	-0.8	-1.0
Medication: Seretide 50 evohaler	1.6	1.8	4.6	2.2	-0.7	0.5
Mean time to correctly identify matches	1.4	2.6	4.8	-0.3	2.2	-1.7
Heart disease (mother)	1.0	1.2	2.5	0.1	-1.6	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.5	-0.4	0.7	-0.7
Whole body fat mass	0.0	0.2	0.4	0.6	-0.2	-0.4
Leg fat mass (right)	0.0	0.1	0.3	0.2	-0.1	-0.6
Arm predicted mass (right)	0.0	0.2	0.4	0.6	-0.3	0.3
Pulse rate, automated reading	1.1	3.7	8.9	3.0	-0.3	1.4
Alcohol intake frequency.	0.5	1.2	3.4	-0.0	0.4	-1.8
Comparative height size at age 10	0.7	3.7	9.7	3.1	1.2	-0.2
Number of full sisters	0.0	0.0	0.1	-0.2	0.0	0.0
Suffer from ‘nerves’	0.9	1.4	3.5	1.9	-0.0	-0.8
Overall health rating	1.3	2.8	6.9	-0.2	-2.6	1.2
Chest pain or discomfort	1.7	2.4	5.5	-0.5	-2.4	1.2
Had major operations	1.2	1.4	2.5	0.0	-1.6	1.3
Age at last live birth	0.1	0.2	0.3	0.6	-0.5	-0.2
Family relationship satisfaction	0.5	0.7	1.5	-0.4	-1.2	0.6
Leg pain on walking	0.2	0.3	0.5	0.7	-0.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	-0.2	-0.6	0.3
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.8	-0.7	-1.1	1.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.4	0.2	0.2
Medication: Aspirin	1.3	1.7	3.3	1.0	-1.8	1.0
Supplements: Vitamin C	1.5	1.8	4.8	-0.3	-2.2	0.6
Knee pain experienced in last month	0.6	0.9	1.3	1.1	0.9	-0.8
Hypertension (Self-reported)	0.6	1.7	4.9	-2.2	-0.4	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.6	-1.3	0.6	-0.9
Illnesses of father: Heart disease	0.9	1.3	3.1	0.8	0.0	-1.8
Illnesses of siblings: Diabetes	0.2	0.2	0.4	0.3	-0.3	-0.6
Smoking status: Previous	0.4	0.6	1.6	-1.3	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.9	1.4	-0.2	-0.4
Whole body fat-free mass	0.0	0.1	0.4	0.6	0.2	0.2
Leg fat-free mass (right)	0.0	0.2	0.3	0.2	0.5	-0.5
Arm fat percentage (left)	0.0	0.1	0.4	0.0	-0.1	-0.6
Average weekly red wine intake	2.5	3.8	5.8	-1.9	-1.3	2.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.3	-1.1	0.7	-0.6
Mood swings	1.5	2.6	5.7	-0.6	-2.4	1.4
Loneliness, isolation	5.4	7.5	12.2	2.4	-3.5	2.1
Long-standing illness, disability or infirmity	1.3	1.9	4.2	0.2	-2.0	1.2
Ever had bowel cancer screening	0.4	0.5	1.3	0.2	-0.2	-1.1
Diabetes diagnosed by doctor	0.4	0.7	1.1	1.1	-0.6	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.1	-0.6	-1.1	1.0
Friendships satisfaction	1.4	1.7	4.2	0.9	-2.0	0.5
Qualifications: nursing, teaching	1.1	1.7	2.0	-1.4	-1.2	1.4
Commuting to job workplace: Walk	1.1	1.2	3.1	1.8	-0.4	0.5
Eye problems/disorders: Cataract	1.2	1.4	3.1	0.1	-1.0	1.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.1	-1.1	-0.6	0.4
Medication for cholesterol	0.7	1.0	1.3	1.1	0.8	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.8	0.9	-1.0	1.3
Back pain experienced in last month	0.1	0.2	0.3	-0.5	-0.5	0.1
Mineral and other dietary supplements	1.6	2.1	3.0	0.7	1.7	-1.7
Breast cancer (self-reported)	0.8	0.9	2.7	-1.6	-0.1	-0.3
Asthma (self-reported)	0.6	1.1	2.2	-1.5	-0.4	1.0
Osteoporosis (self-reported)	1.2	1.5	3.3	0.7	0.7	-1.8
Osteoarthritis (self-reported)	0.7	0.9	1.5	-0.6	0.9	-1.2
Medication: Aspirin	1.3	1.7	3.9	0.8	-2.0	0.7
Medication: Gliclazide	1.3	1.5	3.8	1.9	-0.8	-0.0
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	1.1	-0.0	-0.1
Smoking status: Current	0.2	0.3	0.5	-0.7	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.8	0.8	-1.7	1.1
Whole body water mass	0.0	0.1	0.2	0.5	0.1	0.3
Leg predicted mass (right)	0.0	0.2	0.2	0.2	0.5	-0.5
Arm fat mass (left)	0.0	0.1	0.2	0.1	-0.2	-0.5
Number of self-reported non-cancer illnesses	0.6	1.0	1.6	-1.2	-1.2	0.2
Average weekly champagne plus white wine intake	0.6	0.9	2.5	-1.6	0.3	0.3
Miserableness	1.1	1.9	3.4	-0.4	-1.8	1.5
Guilty feelings	0.6	0.9	2.0	0.2	-1.4	-0.7
Wears glasses or contact lenses	1.0	1.1	3.2	1.8	0.3	-0.2
Ever taken oral contraceptive pill	0.7	0.7	1.8	-1.3	0.2	0.6
Hearing aid user	1.1	1.2	1.6	-1.1	-1.2	1.0
Mother’s age at death	0.1	0.1	0.3	0.6	0.3	-0.1
Financial situation satisfaction	0.1	0.1	0.2	-0.2	0.5	-0.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.9	1.4	1.0	-0.6
Commuting to job workplace: Public transport	0.4	0.5	1.2	-0.3	0.5	-1.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	0.3	-0.4	-0.6
Medication: Blood pressure	0.8	1.5	2.4	-1.6	-1.2	-0.8
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.1	-0.2	-0.4
Supplements: Fish oil (including cod liver oil)	2.6	3.4	4.4	-1.3	-2.1	2.0
High cholesterol (Self-reported)	0.3	0.5	1.1	-1.0	-0.6	0.1
Medication: Bendroflumethiazide	0.3	0.5	1.4	-1.2	-0.1	0.2
Medication: Paracetamol	0.3	0.5	0.7	0.8	-0.8	0.3
Medication: Lisinopril	0.6	0.8	1.2	-0.3	-1.1	1.0
Medication: Atorvastatin	0.2	0.2	0.4	0.4	0.1	-0.7
Illnesses of father: High blood pressure	0.6	0.8	1.3	-0.8	-1.2	0.6
Alcohol drinker status: Never	0.3	0.4	1.1	-0.2	-0.0	-1.0
Ever smoked	0.7	1.2	3.2	-1.8	0.6	0.5
Basal metabolic rate	0.0	0.2	0.5	0.7	0.2	-0.0
Leg fat percentage (left)	0.0	0.2	0.3	0.0	-0.4	-0.5
Arm fat-free mass (left)	0.0	0.1	0.1	0.3	-0.1	0.2
Number of operations (self-reported)	0.2	0.3	0.8	-0.4	-0.9	0.0
Average weekly beer plus cider intake	1.9	2.7	4.2	-0.8	-2.0	1.8
Irritability	0.7	1.1	2.8	0.7	-1.7	0.3
Risk taking	1.0	1.5	2.8	-0.6	1.7	-1.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	0.8	-0.4	0.2
Fractured/broken bones in last 5 years	0.9	1.1	3.1	-0.6	-1.7	-0.2
Age started oral contraceptive pill	0.6	0.7	1.3	-0.9	0.1	-1.1
Diastolic blood pressure, automated reading	1.2	3.8	6.6	0.2	-2.2	2.6
Ever depressed for a whole week	0.7	0.8	2.0	-1.4	-0.6	0.2
Unable to work because of sickness or disability	1.9	2.5	5.1	-0.6	-2.3	1.4
Commuting to job workplace: Cycle	0.0	0.1	0.1	-0.4	0.1	-0.1
Myopia	1.9	2.8	8.1	2.8	0.4	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.1	1.8	0.9	-0.0
Cholesterol lowering medication	0.4	0.6	1.5	-0.5	0.3	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	2.7	-1.6	-1.0	-0.9
Pain experienced in last month	0.1	0.2	0.7	-0.1	-0.0	0.8
Supplements: Calcium	0.9	1.0	1.6	-1.3	0.5	-1.1
Basal cell carcinoma (self-reported)	2.0	2.4	4.9	-0.1	-2.2	1.5
Heart attack/myocardial infarction (self-reported)	3.2	4.1	6.0	-1.3	-2.2	2.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.4	-1.2	-0.9	-0.4
Heart disease (siblings)	0.8	0.9	1.6	0.6	-1.3	0.9
Alcohol drinker status: Previous	1.2	1.3	3.0	-0.5	-1.7	0.8
Pack years of smoking	0.2	0.2	0.6	0.2	0.2	-0.8
Impedance of whole body	0.2	0.8	1.9	1.4	-0.1	-0.6
Leg fat mass (left)	0.0	0.1	0.3	-0.0	-0.2	-0.5
Arm predicted mass (left)	0.0	0.1	0.2	0.1	-0.5	0.2