Hub : Genes

FOXL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.1435 0.0400 0.00042 0.159 NA 0.163 NA 0.175 2.0e-15 NA 8.6e-16 NA 6.1e-17
2 TCGA Breast Invasive Carcinoma 0.0220 0.0114 0.00520 -0.001 0.006 0.003 NA -0.001 7.2e-01 0.014 8.5e-02 NA 4.8e-01
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0337 0.0161 0.00360 0.005 0.007 0.002 NA 0.002 7.9e-02 0.046 1.8e-01 NA 1.7e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 0.9 1.7 -0.8 -0.7 1.3
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 0.4 -0.3 0.1
Depressed Affect (Nagel 2018) 0.9 1.8 2.2 1.3 1.5 -1.3
Depression (Nagel 2018) 4.0 5.9 9.8 1.4 3.1 -2.5
Intelligence (Savage-Jansen 2018) 0.4 1.2 1.7 1.2 1.3 -0.7
Neuroticism (Nagel 2018) 0.6 1.4 2.0 1.1 1.4 -1.0
Schizophrenia (2018) 0.4 0.8 1.4 1.2 0.1 -1.0
Schizophrenia vs Biploar Disorder 0.5 0.7 1.6 0.5 -0.4 -1.3
Worry (Nagel 2018) 0.8 1.6 2.0 1.2 1.4 -1.2
Alzheimer’s Disease (in mother) 1.5 1.8 3.3 1.3 0.7 -1.8
Alzheimer’s Disease (in father) 0.3 0.4 0.9 0.3 -0.4 -0.9
Alzheimer’s Disease (including proxy) 1.1 1.5 4.2 0.6 0.1 -2.1
Crohns Disease (2017) 0.6 1.3 1.7 1.0 1.1 -1.3
Irritable Bowel Disease (IBD) 0.0 0.1 0.3 -0.6 0.1 0.1
Ulcerative Colitis (UC) 0.9 1.7 3.4 -1.8 -0.6 1.1
Major Depression (MDD) 2.0 2.4 5.1 0.9 2.2 -1.2
Reaction Time 0.3 0.5 1.2 -1.1 -0.5 0.2
Verbal and Numeric Reasoning (VNR) 1.0 2.5 3.0 1.6 1.7 -1.3
Breast Cancer 0.2 0.4 0.7 -0.6 0.8 -0.4
Ovarian Cancer 0.1 0.2 0.4 -0.6 -0.3 0.1
Prostate Cancer 1.1 1.6 3.5 -0.8 -0.8 1.9
Age at First Birth 0.6 0.9 2.6 0.2 0.1 -1.6
Bipolar Disorder (2011) 0.8 0.8 1.3 0.0 -1.1 -1.0
Body Mass Index (BMI) (2010) 3.1 4.2 7.9 1.6 1.5 -2.8
Coronary Artery Disease (CAD) 0.5 0.6 1.2 0.0 -1.1 0.7
Crohns Disease (2012) 0.5 0.8 1.9 1.4 0.5 -0.3
Mean Putamen Volume 0.6 0.7 1.6 -0.6 -1.3 -0.3
Fasting Glucose 0.2 0.3 0.8 -0.9 -0.2 0.0
HbA1C 0.3 0.3 0.6 -0.8 -0.5 0.1
HDL Cholesterol 1.5 2.5 3.3 -1.8 -1.4 1.5
LDL Cholesterol 0.4 0.6 1.3 -0.4 -1.1 -0.5
Lupus 0.5 0.8 1.8 0.5 -1.4 -0.4
Neuroticism (2016) 0.2 0.4 0.8 0.9 0.5 -0.2
Primary Biliary Cirrhosis 0.9 1.3 2.0 1.3 -1.4 0.6
Rheumatoid Arthritis 0.9 1.2 2.3 -0.2 -1.1 1.5
Schizophrenia (2014) 0.1 0.2 0.4 0.6 -0.1 -0.2
Triglycerides 1.4 2.4 3.7 1.7 0.8 -1.9
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.1 1.4 -1.0 0.6
Ulcerative Colitis 0.6 0.9 2.4 -1.5 -0.1 0.7
Blood Eosinophil Count 0.2 1.2 2.8 1.7 0.7 -0.6
Blood Platelet Count 0.1 1.7 2.5 1.4 -1.6 -0.7
Blood Red Count 0.0 0.4 0.6 -0.7 0.3 -0.8
Blood White Count 0.1 0.5 0.8 0.9 -0.8 -0.5
Heel T-Score 2.3 18.3 53.7 1.0 7.3 0.3
BMI 0.2 0.9 1.8 0.5 -0.8 -1.4
Height 1.4 27.8 57.9 3.4 7.6 -3.8
Waist Hip Ratio (WHR) 0.8 3.8 4.8 -2.1 1.4 2.2
Systolic Blood Pressure 0.4 2.0 3.6 0.2 -1.5 1.9
Smoking Status 1.5 3.5 6.5 0.7 2.5 -1.9
Allergy or Eczema 2.3 5.9 12.6 -1.4 -3.5 1.8
Cardiovascular Disease 0.2 0.6 1.8 0.3 -1.3 0.0
Hypothyroidism (self reported) 0.7 1.7 3.8 -1.9 -0.1 1.1
Respiratory disease 0.8 1.9 4.4 -0.4 -2.1 1.0
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.4 0.1 -1.2 0.6
Lung FEV1/FVC ratio 0.7 3.8 9.2 1.2 0.9 -3.0
Lung FVC 0.1 0.7 1.8 -1.4 0.1 -0.6
Neuroticism 1.2 2.9 5.2 1.4 2.3 -1.2
Chronotype (morning person) 0.2 0.5 1.0 -0.2 1.0 -0.6
Hair Pigment 0.0 1.0 1.7 1.3 1.1 0.4
Tanning 0.1 1.0 1.6 1.2 0.3 -1.3
Hand grip strength (left) 3.6 9.4 12.7 2.0 3.4 -3.6
Number of treatments/medications taken 0.9 1.7 4.8 2.2 0.4 -0.4
Average weekly spirits intake 0.4 0.5 0.8 -0.7 -0.4 0.9
Sensitivity / hurt feelings 0.1 0.1 0.3 0.1 0.5 -0.1
Frequency of depressed mood in last 2 weeks 2.2 3.1 5.5 1.1 2.3 -1.7
Hearing difficulty/problems: Yes 0.9 1.3 2.5 0.8 1.6 -1.0
Relative age of first facial hair 1.5 3.0 4.1 -1.0 -2.0 2.0
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 2.7 -0.0 -1.7 0.9
Ever used hormone-replacement therapy (HRT) 1.1 1.4 2.6 0.9 1.6 0.8
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 -0.1 0.5 0.6
Systolic blood pressure, automated reading 0.1 0.3 0.5 0.3 -0.7 0.5
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.0 -0.6 0.6 1.0
Angina 2.2 2.9 5.3 2.3 0.2 -1.9
Medication for hormone replacement therapy 0.3 0.3 0.7 0.0 -0.5 0.8
Vitamin and mineral supplements 1.3 1.7 2.6 -1.6 -1.1 1.2
Supplements: Zinc 1.0 1.1 2.3 1.0 -0.4 -1.5
Medication: Co-codamol 0.2 0.3 0.6 0.8 -0.1 -0.5
Medication: Metformin 0.3 0.4 0.9 1.0 0.4 -0.3
Diabetes (father) 0.4 0.5 0.6 0.7 0.7 -0.6
Diabetes (mother) 0.9 1.1 1.4 -0.9 -1.2 1.1
Severe depression (siblings) 1.6 1.8 2.8 -1.7 -0.8 1.4
Pack years adult smoking proportion 0.7 1.1 2.0 1.4 1.0 -0.5
Impedance of leg (right) 0.3 1.7 3.2 -1.3 0.3 1.8
Leg fat-free mass (left) 1.0 5.3 7.0 2.1 2.1 -2.6
Trunk fat percentage 0.0 0.1 0.3 -0.0 -0.6 -0.3
Hand grip strength (right) 1.3 3.5 5.8 0.5 2.4 -2.1
Townsend deprivation index at recruitment 0.3 0.4 0.8 0.9 0.6 0.1
Current tobacco smoking 0.2 0.3 0.4 -0.3 0.7 -0.6
Average weekly fortified wine intake 0.9 1.1 2.5 0.7 -0.5 -1.6
Maternal smoking around birth 0.1 0.2 0.4 -0.3 -0.6 0.4
Fed-up feelings 1.8 3.2 3.6 1.9 1.6 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 3.6 4.8 7.7 1.8 2.8 -1.9
Relative age voice broke 2.9 4.4 5.9 -1.7 -2.1 2.4
Taking other prescription medications 1.0 1.5 4.2 2.0 0.5 0.2
Age when periods started (menarche) 0.1 0.2 0.3 -0.4 -0.5 -0.4
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.3 -0.5 1.1 0.5
Heel bone mineral density (BMD) T-score, automated (left) 2.1 4.8 13.9 0.7 3.7 -0.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 0.0 0.9 0.7
Qualifications: CSEs or equivalent 1.3 1.7 3.8 0.7 2.0 -0.9
Serious illness, injury or assault to yourself 0.6 0.8 1.3 0.9 -1.1 -0.4
High blood pressure 0.3 0.7 1.9 1.4 -0.5 -0.2
Hayfever, allergic rhinitis or eczema 2.1 4.6 10.7 -0.9 -3.3 1.6
Multivitamins +/- minerals 1.1 1.4 2.1 1.4 1.5 -0.4
Stomach or abdominal pain in last month 0.6 0.8 1.8 0.2 -0.7 -1.3
Supplements: Glucosamine 0.4 0.6 1.0 0.0 1.0 -0.8
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.4 -0.5 -0.4 0.6
Medication: Atenolol 1.4 1.7 3.4 1.3 0.3 -1.9
Medication: Levothyroxine sodium 1.0 1.8 3.9 -2.0 -0.4 1.1
Sitting height 1.6 11.4 24.0 1.7 4.9 -2.7
Chronic bronchitis/emphysema (father) 1.0 1.1 2.4 1.5 -0.9 -0.3
High blood pressure (mother) 0.3 0.4 0.8 -0.9 -0.4 0.6
Body mass index (BMI) 0.2 1.0 2.0 0.4 -0.9 -1.4
Impedance of leg (left) 0.2 1.1 1.8 -1.0 0.7 1.3
Leg predicted mass (left) 1.0 5.2 7.0 2.1 2.1 -2.6
Trunk fat mass 0.1 0.5 1.2 0.5 0.2 -1.1
Waist circumference 0.0 0.1 0.4 0.2 0.0 -0.6
Number of incorrect matches in round 0.9 1.4 1.7 1.2 1.3 -1.1
Past tobacco smoking 0.5 0.9 2.2 -0.4 -1.5 0.5
Alcohol usually taken with meals 0.2 0.3 0.7 -0.1 0.9 -0.3
Nervous feelings 1.1 2.0 3.2 1.8 1.4 -0.8
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 5.8 0.5 2.4 -1.2
Hearing difficulty/problems with background noise 0.4 0.7 1.6 1.3 -0.3 -0.5
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.2 0.4 0.1
Had menopause 1.0 1.2 1.8 1.2 0.7 1.3
Had other major operations 0.4 0.5 0.8 0.9 0.3 -0.8
Forced vital capacity (FVC) 0.9 3.4 8.1 0.3 2.8 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.1 11.3 0.9 3.4 -0.1
Ever unenthusiastic/disinterested for a whole week 2.0 2.4 4.2 2.0 1.4 -1.1
Qualifications: None of the above 0.3 0.6 1.0 0.8 1.0 -0.2
Financial difficulties in last 2 years 0.9 1.2 2.3 1.5 0.6 -0.9
Mouth/teeth dental problems 0.3 0.4 0.5 0.7 0.6 0.6
Heart attack 0.9 1.1 1.9 1.0 -0.6 -1.4
Allergy 1.5 3.5 8.0 0.8 2.8 -1.4
Pain all over the body in last month 0.3 0.3 0.8 0.9 -0.4 -0.3
Diabetes (self-reported) 0.8 1.3 2.8 -0.4 -1.7 1.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.1 -0.5 -1.0 -0.1
Medication: Ramipril 2.4 3.1 5.5 2.4 1.1 -1.6
Medication: Simvastatin 0.1 0.2 0.3 0.3 -0.5 0.5
Fluid intelligence score 0.3 0.6 1.5 1.2 0.3 -0.6
Illnesses of siblings 1.4 2.0 3.7 1.2 0.9 -1.9
Neuroticism score 1.2 2.4 5.6 1.0 2.4 -0.8
Weight 0.5 2.6 4.5 1.2 1.4 -2.1
Impedance of arm (right) 0.3 1.3 3.3 -0.5 0.4 1.8
Arm fat percentage (right) 0.2 0.8 1.5 0.5 -1.2 -0.8
Trunk fat-free mass 1.0 5.8 7.0 1.9 2.6 -2.6
Hip circumference 0.6 2.7 5.0 1.7 0.3 -2.2
Time employed in main current job 0.9 1.0 3.0 -0.1 1.7 -0.2
Alcohol intake versus 10 years previously 0.4 0.6 1.8 -0.3 -1.3 0.2
Father’s age at death 0.1 0.2 0.2 -0.2 -0.5 0.4
Worrier / anxious feelings 0.7 1.3 2.5 -1.2 1.6 0.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 0.6 0.0 -0.1
Falls in the last year 0.3 0.4 1.1 -0.3 -1.0 0.3
Hair/balding pattern: Pattern 3 0.2 0.3 0.4 -0.3 -0.6 0.6
Number of live births 0.4 0.5 0.6 0.6 -0.8 0.8
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 5.9 0.0 2.4 -2.0
Pulse rate 0.3 0.5 1.2 1.1 0.3 0.5
Happiness 1.6 1.9 3.2 1.8 1.5 -0.4
Noisy workplace 1.0 1.3 3.3 -1.8 0.1 -0.7
Qualifications: A levels/AS levels or equivalent 0.9 2.1 4.9 -1.1 -2.2 0.1
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.9 5.0 -2.2 -0.7 0.3
Mouth/teeth dental problems: Dentures 0.6 1.1 2.9 -0.6 -1.7 0.2
Asthma 2.2 4.3 7.6 -0.7 -2.8 2.2
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.1 0.3 0.5 -1.4
Medication: Cholesterol lowering 0.2 0.4 0.6 0.1 -0.7 -0.8
Depression (self-reported) 2.7 3.2 4.4 1.8 1.4 -2.1
Medication: Lansoprazole 4.9 5.6 9.0 1.9 2.0 -3.0
Prospective memory result 0.3 0.3 0.8 -0.2 0.5 -0.9
Lung cancer (father) 0.3 0.3 0.5 0.7 -0.1 -0.6
Illnesses of mother 0.1 0.1 0.2 0.5 0.4 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.5 7.7 -0.3 2.8 -1.6
Pulse wave Arterial Stiffness index 0.7 0.8 1.6 1.2 0.8 -0.3
Impedance of arm (left) 0.4 1.7 4.4 -0.8 -0.3 2.1
Arm fat mass (right) 0.2 0.9 1.7 1.0 -0.1 -1.3
Trunk predicted mass 1.0 5.7 6.9 1.9 2.6 -2.5
Standing height 1.0 9.9 23.8 1.8 4.9 -1.6
Length of working week for main job 0.8 0.9 1.7 1.3 0.2 -1.0
Exposure to tobacco smoke at home 0.1 0.1 0.2 0.1 0.4 -0.1
Breastfed as a baby 1.0 1.2 1.5 1.1 1.2 -1.0
Tense / ‘highly strung’ 0.4 0.7 1.1 1.1 0.8 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.2 0.5 -0.2 0.5
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 0.1 0.5 -0.1
Birth weight of first child 0.9 1.7 3.7 -1.9 0.4 1.1
Peak expiratory flow (PEF) 1.2 2.8 5.5 -0.1 2.3 -1.7
Pulse wave reflection index 0.6 0.8 1.6 -0.4 -1.3 0.7
Ever highly irritable/argumentative for 2 days 5.0 6.0 8.3 1.6 2.7 -2.9
Loud music exposure frequency 0.9 1.0 2.9 0.3 0.2 -1.7
Qualifications: O levels/GCSEs or equivalent 2.1 3.4 7.2 -1.6 -2.7 0.7
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.1 -1.0 -0.8 -0.0
Blood clot in the leg (DVT) 0.3 0.3 0.9 -0.1 0.9 -0.3
Medication: Paracetamol 2.1 3.4 6.0 0.8 1.9 -2.5
Headache pain in last month 1.2 2.0 3.1 -0.4 1.8 -1.6
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.3 -0.5 0.6 0.4
Glaucoma (self-reported) 0.5 0.6 1.6 -0.3 1.3 0.4
Gout (self-reported) 0.2 0.3 0.8 0.1 -0.9 -0.1
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 2.6 -1.6 -0.4 1.4
Medication: Amlodipine 0.9 1.2 1.8 1.0 0.9 -1.4
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.9 -0.0 -1.2 1.4
Birth weight 0.2 0.4 0.8 -0.2 0.9 0.5
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.4 1.2 0.6 -1.5
High blood pressure (siblings) 0.7 1.0 2.1 -0.7 -0.5 1.5
Forced vital capacity (FVC), Best measure 1.0 3.6 9.8 -0.4 3.1 -0.9
Body fat percentage 0.1 0.3 0.7 -0.1 -0.9 -0.4
Leg fat percentage (right) 0.1 0.4 0.7 0.1 -0.8 -0.7
Arm fat-free mass (right) 0.9 4.6 6.0 1.6 2.3 -2.4
Exposure to tobacco smoke outside home 0.1 0.1 0.2 0.0 -0.1 -0.5
Comparative body size at age 10 0.2 0.4 0.8 -0.3 -0.9 -0.7
Number of full brothers 0.7 0.9 1.6 -1.1 -0.2 1.3
Worry too long after embarrassment 0.4 0.7 2.1 -0.3 -0.1 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.0 1.4 -0.5 -0.2
Wheeze or whistling in the chest in last year 0.8 1.4 3.6 0.2 -1.9 0.8
Number of children fathered 2.3 2.6 6.3 -2.5 -0.6 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.6 1.6 0.2 -0.4
Age at first live birth 0.5 0.9 1.5 -1.2 -1.0 0.5
Pulse wave peak to peak time 0.3 0.4 0.9 -1.0 -0.4 0.1
Health satisfaction 0.5 0.6 1.7 0.3 1.3 0.4
Shortness of breath walking on level ground 0.9 1.1 1.8 0.5 1.1 -1.3
Qualifications: College or University degree 0.5 1.6 2.3 1.3 0.9 -1.5
Eye problems/disorders: None of the above 0.9 1.0 1.8 0.8 1.3 -0.8
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.5 0.7 -0.5 -0.4
Emphysema/chronic bronchitis 1.1 1.3 3.0 0.9 0.0 -1.7
Medication for pain relief, constipation, heartburn 3.1 5.2 8.4 -2.3 -1.3 2.9
Neck or shoulder pain in last month 0.4 0.5 1.1 0.3 0.7 -1.0
Medication: Blood pressure 0.0 0.1 0.2 -0.1 0.4 0.1
Angina (self-reported) 2.3 3.0 4.6 2.1 0.4 -2.0
Migraine (self-reported) 0.3 0.3 0.8 0.2 0.9 0.4
Medication: Ibuprofen 0.4 0.5 1.2 -0.1 0.6 -1.1
Medication: Allopurinol 0.2 0.3 0.4 -0.5 -0.6 0.5
Medication: Omeprazole 3.3 4.0 5.3 2.3 1.6 -2.0
Medication: Seretide 50 evohaler 0.3 0.3 0.5 0.6 -0.7 0.3
Mean time to correctly identify matches 0.4 0.8 1.4 -1.2 -0.7 0.7
Heart disease (mother) 0.4 0.5 1.4 1.2 -0.3 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.3 -1.1 0.1 0.6
Whole body fat mass 0.2 0.8 1.7 0.9 0.1 -1.3
Leg fat mass (right) 0.2 0.8 2.0 0.7 -0.1 -1.4
Arm predicted mass (right) 0.8 4.0 5.4 1.3 2.2 -2.3
Pulse rate, automated reading 0.2 0.8 2.2 1.5 0.2 0.4
Alcohol intake frequency. 0.1 0.2 0.6 0.0 0.4 -0.8
Comparative height size at age 10 0.9 5.0 8.0 1.8 2.8 -1.9
Number of full sisters 0.7 0.8 1.4 -1.2 0.1 1.0
Suffer from ‘nerves’ 2.4 3.7 9.3 3.0 1.2 -0.7
Overall health rating 0.2 0.4 1.2 0.1 -0.2 1.1
Chest pain or discomfort 0.4 0.6 1.0 1.0 -0.6 -0.6
Had major operations 3.1 3.6 7.8 -2.8 -1.5 0.8
Age at last live birth 1.8 2.6 3.8 -1.9 -1.9 0.7
Family relationship satisfaction 1.7 2.1 3.8 1.9 1.5 -0.4
Leg pain on walking 0.6 0.8 1.3 0.9 0.5 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 0.0 -0.5 0.2
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.8 -0.1 -0.9 -0.9
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.3 -0.5 -0.1 0.4
Medication: Aspirin 0.1 0.1 0.3 0.6 -0.3 0.0
Supplements: Vitamin C 1.9 2.2 2.4 1.6 1.4 -1.5
Knee pain experienced in last month 0.6 1.0 2.8 -1.7 -0.1 -0.3
Hypertension (Self-reported) 0.3 0.9 2.1 1.4 -0.6 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.4 2.8 5.3 1.0 1.4 -2.3
Illnesses of father: Heart disease 2.1 3.0 4.1 1.8 1.3 -2.0
Illnesses of siblings: Diabetes 0.3 0.3 0.9 0.1 -0.0 1.0
Smoking status: Previous 0.5 0.8 2.0 0.7 1.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 4.0 -0.3 2.0 -1.2
Whole body fat-free mass 1.0 5.8 7.1 2.0 2.5 -2.7
Leg fat-free mass (right) 1.0 5.4 6.9 2.1 2.2 -2.6
Arm fat percentage (left) 0.2 0.8 1.8 0.4 -1.3 -0.6
Average weekly red wine intake 0.9 1.3 2.0 0.1 -1.4 1.4
Handedness (chirality/laterality): Left-handed 1.5 1.7 3.0 1.3 1.7 -0.7
Mood swings 0.4 0.8 2.3 0.2 1.5 -0.3
Loneliness, isolation 1.5 2.1 4.3 1.1 2.1 -0.8
Long-standing illness, disability or infirmity 0.2 0.3 0.5 0.5 -0.5 0.7
Ever had bowel cancer screening 2.4 2.8 3.0 -1.6 -1.7 1.7
Diabetes diagnosed by doctor 0.5 0.8 1.9 0.1 -1.4 0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 2.1 1.1 1.4 -1.5
Friendships satisfaction 0.3 0.3 0.9 0.9 -0.3 0.3
Qualifications: nursing, teaching 3.8 6.0 7.4 -2.7 -2.2 2.3
Commuting to job workplace: Walk 0.0 0.1 0.1 -0.4 0.0 0.2
Eye problems/disorders: Cataract 0.5 0.6 0.8 -0.9 -0.8 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.1 0.1 0.1 -1.1
Medication for cholesterol 1.0 1.6 4.5 -2.1 -0.0 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.6 0.2 0.5 0.8
Back pain experienced in last month 0.1 0.1 0.2 0.5 -0.0 -0.1
Mineral and other dietary supplements 2.0 2.7 4.1 -2.0 -1.6 1.2
Breast cancer (self-reported) 1.9 2.2 5.3 -0.8 -2.3 0.9
Asthma (self-reported) 2.4 4.7 9.3 -0.6 -3.0 2.1
Osteoporosis (self-reported) 2.3 2.8 3.6 -1.4 -1.7 1.9
Osteoarthritis (self-reported) 0.2 0.3 0.5 0.1 0.5 -0.7
Medication: Aspirin 0.0 0.1 0.1 0.2 -0.3 -0.2
Medication: Gliclazide 0.3 0.4 0.7 0.7 0.2 0.8
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 -0.2 0.1 0.7
Smoking status: Current 0.3 0.5 0.8 -0.3 0.8 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.2 0.3 0.7 -1.1
Whole body water mass 1.0 5.7 7.1 2.0 2.4 -2.7
Leg predicted mass (right) 1.0 5.2 6.6 2.1 2.2 -2.6
Arm fat mass (left) 0.3 1.0 1.8 1.1 0.0 -1.4
Number of self-reported non-cancer illnesses 0.8 1.4 2.7 1.6 -1.2 -0.1
Average weekly champagne plus white wine intake 0.9 1.3 3.6 0.3 -1.9 0.3
Miserableness 0.4 0.7 1.1 1.1 0.6 -0.7
Guilty feelings 0.9 1.4 2.7 1.6 1.3 0.0
Wears glasses or contact lenses 0.7 0.8 1.9 -1.4 0.4 0.5
Ever taken oral contraceptive pill 0.9 1.0 1.3 -1.0 -1.1 0.8
Hearing aid user 1.0 1.1 2.2 -1.0 -0.3 1.5
Mother’s age at death 0.3 0.3 0.9 -1.0 0.1 0.1
Financial situation satisfaction 5.4 6.7 14.3 1.8 3.8 -1.6
Tinnitus: Yes, now most or all of the time 0.9 1.1 1.6 1.3 1.2 -0.6
Commuting to job workplace: Public transport 0.5 0.6 1.6 -0.2 1.3 -0.3
Eye problems/disorders: Glaucoma 0.8 0.9 1.7 -0.9 1.3 0.5
Medication: Blood pressure 0.8 1.6 3.1 1.8 0.7 -1.1
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.3 0.6 0.3 -0.4
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.0 1.4 1.0 0.2
High cholesterol (Self-reported) 0.0 0.1 0.1 0.3 0.0 0.3
Medication: Bendroflumethiazide 1.1 1.6 3.3 1.0 1.8 -0.7
Medication: Paracetamol 2.8 4.3 6.8 1.3 2.1 -2.6
Medication: Lisinopril 0.1 0.2 0.3 0.1 -0.6 -0.5
Medication: Atorvastatin 0.4 0.5 1.4 1.2 0.1 -0.1
Illnesses of father: High blood pressure 2.1 2.6 3.4 1.9 1.8 -1.2
Alcohol drinker status: Never 0.2 0.2 0.3 -0.6 -0.4 0.0
Ever smoked 1.0 1.7 4.3 0.5 2.1 -0.7
Basal metabolic rate 1.0 5.5 7.2 2.0 2.4 -2.7
Leg fat percentage (left) 0.2 0.6 1.3 0.5 -0.6 -1.2
Arm fat-free mass (left) 1.2 6.1 6.9 2.2 2.6 -2.6
Number of operations (self-reported) 0.3 0.5 1.1 -1.1 -0.4 -0.5
Average weekly beer plus cider intake 5.5 7.9 10.9 3.3 1.5 -3.3
Irritability 0.6 1.1 1.7 0.6 1.3 -1.1
Risk taking 0.2 0.3 0.4 0.6 0.2 -0.7
Ever had prostate specific antigen (PSA) test 1.6 1.9 2.9 -1.7 -1.0 1.3
Fractured/broken bones in last 5 years 4.2 5.4 8.6 -1.6 -2.9 2.3
Age started oral contraceptive pill 0.7 0.8 1.3 -1.1 -0.1 1.1
Diastolic blood pressure, automated reading 0.6 1.8 2.9 1.7 -0.0 -1.6
Ever depressed for a whole week 1.1 1.3 2.2 0.9 1.0 -1.5
Unable to work because of sickness or disability 0.3 0.4 1.1 1.0 0.2 0.1
Commuting to job workplace: Cycle 2.1 2.5 4.1 1.8 2.0 -0.5
Myopia 0.6 0.9 1.9 -0.4 0.8 1.4
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.4 -1.5 1.1 0.6
Cholesterol lowering medication 0.3 0.5 0.8 0.9 -0.2 0.8
Medication: Omeprazole (e.g. Zanprol) 3.8 4.6 6.0 2.3 1.6 -2.5
Pain experienced in last month 1.3 2.2 5.0 -1.3 -0.4 2.2
Supplements: Calcium 1.9 2.1 4.0 2.0 -0.4 -1.5
Basal cell carcinoma (self-reported) 2.0 2.4 6.0 0.9 -2.5 0.7
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.8 0.9 -0.5 -1.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.8 -0.2 0.9 -0.3
Heart disease (siblings) 0.6 0.8 2.1 0.3 -1.4 -0.4
Alcohol drinker status: Previous 1.1 1.2 3.5 -0.4 -1.9 -0.3
Pack years of smoking 0.4 0.6 0.9 0.9 0.9 -0.0
Impedance of whole body 0.3 1.4 3.0 -1.0 0.5 1.7
Leg fat mass (left) 0.4 1.4 3.1 1.0 0.2 -1.8
Arm predicted mass (left) 1.2 5.9 7.3 1.9 2.6 -2.7