Hub : Genes

FOXL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1435	0.0400	0.00042	0.159	NA	0.163	NA	0.175	2.0e-15	NA	8.6e-16	NA	6.1e-17
2	TCGA	Breast Invasive Carcinoma	0.0220	0.0114	0.00520	-0.001	0.006	0.003	NA	-0.001	7.2e-01	0.014	8.5e-02	NA	4.8e-01
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0337	0.0161	0.00360	0.005	0.007	0.002	NA	0.002	7.9e-02	0.046	1.8e-01	NA	1.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	1.7	-0.8	-0.7	1.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.4	-0.3	0.1
Depressed Affect (Nagel 2018)	0.9	1.8	2.2	1.3	1.5	-1.3
Depression (Nagel 2018)	4.0	5.9	9.8	1.4	3.1	-2.5
Intelligence (Savage-Jansen 2018)	0.4	1.2	1.7	1.2	1.3	-0.7
Neuroticism (Nagel 2018)	0.6	1.4	2.0	1.1	1.4	-1.0
Schizophrenia (2018)	0.4	0.8	1.4	1.2	0.1	-1.0
Schizophrenia vs Biploar Disorder	0.5	0.7	1.6	0.5	-0.4	-1.3
Worry (Nagel 2018)	0.8	1.6	2.0	1.2	1.4	-1.2
Alzheimer’s Disease (in mother)	1.5	1.8	3.3	1.3	0.7	-1.8
Alzheimer’s Disease (in father)	0.3	0.4	0.9	0.3	-0.4	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.5	4.2	0.6	0.1	-2.1
Crohns Disease (2017)	0.6	1.3	1.7	1.0	1.1	-1.3
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	-0.6	0.1	0.1
Ulcerative Colitis (UC)	0.9	1.7	3.4	-1.8	-0.6	1.1
Major Depression (MDD)	2.0	2.4	5.1	0.9	2.2	-1.2
Reaction Time	0.3	0.5	1.2	-1.1	-0.5	0.2
Verbal and Numeric Reasoning (VNR)	1.0	2.5	3.0	1.6	1.7	-1.3
Breast Cancer	0.2	0.4	0.7	-0.6	0.8	-0.4
Ovarian Cancer	0.1	0.2	0.4	-0.6	-0.3	0.1
Prostate Cancer	1.1	1.6	3.5	-0.8	-0.8	1.9
Age at First Birth	0.6	0.9	2.6	0.2	0.1	-1.6
Bipolar Disorder (2011)	0.8	0.8	1.3	0.0	-1.1	-1.0
Body Mass Index (BMI) (2010)	3.1	4.2	7.9	1.6	1.5	-2.8
Coronary Artery Disease (CAD)	0.5	0.6	1.2	0.0	-1.1	0.7
Crohns Disease (2012)	0.5	0.8	1.9	1.4	0.5	-0.3
Mean Putamen Volume	0.6	0.7	1.6	-0.6	-1.3	-0.3
Fasting Glucose	0.2	0.3	0.8	-0.9	-0.2	0.0
HbA1C	0.3	0.3	0.6	-0.8	-0.5	0.1
HDL Cholesterol	1.5	2.5	3.3	-1.8	-1.4	1.5
LDL Cholesterol	0.4	0.6	1.3	-0.4	-1.1	-0.5
Lupus	0.5	0.8	1.8	0.5	-1.4	-0.4
Neuroticism (2016)	0.2	0.4	0.8	0.9	0.5	-0.2
Primary Biliary Cirrhosis	0.9	1.3	2.0	1.3	-1.4	0.6
Rheumatoid Arthritis	0.9	1.2	2.3	-0.2	-1.1	1.5
Schizophrenia (2014)	0.1	0.2	0.4	0.6	-0.1	-0.2
Triglycerides	1.4	2.4	3.7	1.7	0.8	-1.9
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.1	1.4	-1.0	0.6
Ulcerative Colitis	0.6	0.9	2.4	-1.5	-0.1	0.7
Blood Eosinophil Count	0.2	1.2	2.8	1.7	0.7	-0.6
Blood Platelet Count	0.1	1.7	2.5	1.4	-1.6	-0.7
Blood Red Count	0.0	0.4	0.6	-0.7	0.3	-0.8
Blood White Count	0.1	0.5	0.8	0.9	-0.8	-0.5
Heel T-Score	2.3	18.3	53.7	1.0	7.3	0.3
BMI	0.2	0.9	1.8	0.5	-0.8	-1.4
Height	1.4	27.8	57.9	3.4	7.6	-3.8
Waist Hip Ratio (WHR)	0.8	3.8	4.8	-2.1	1.4	2.2
Systolic Blood Pressure	0.4	2.0	3.6	0.2	-1.5	1.9
Smoking Status	1.5	3.5	6.5	0.7	2.5	-1.9
Allergy or Eczema	2.3	5.9	12.6	-1.4	-3.5	1.8
Cardiovascular Disease	0.2	0.6	1.8	0.3	-1.3	0.0
Hypothyroidism (self reported)	0.7	1.7	3.8	-1.9	-0.1	1.1
Respiratory disease	0.8	1.9	4.4	-0.4	-2.1	1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.4	0.1	-1.2	0.6
Lung FEV1/FVC ratio	0.7	3.8	9.2	1.2	0.9	-3.0
Lung FVC	0.1	0.7	1.8	-1.4	0.1	-0.6
Neuroticism	1.2	2.9	5.2	1.4	2.3	-1.2
Chronotype (morning person)	0.2	0.5	1.0	-0.2	1.0	-0.6
Hair Pigment	0.0	1.0	1.7	1.3	1.1	0.4
Tanning	0.1	1.0	1.6	1.2	0.3	-1.3
Hand grip strength (left)	3.6	9.4	12.7	2.0	3.4	-3.6
Number of treatments/medications taken	0.9	1.7	4.8	2.2	0.4	-0.4
Average weekly spirits intake	0.4	0.5	0.8	-0.7	-0.4	0.9
Sensitivity / hurt feelings	0.1	0.1	0.3	0.1	0.5	-0.1
Frequency of depressed mood in last 2 weeks	2.2	3.1	5.5	1.1	2.3	-1.7
Hearing difficulty/problems: Yes	0.9	1.3	2.5	0.8	1.6	-1.0
Relative age of first facial hair	1.5	3.0	4.1	-1.0	-2.0	2.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.7	-0.0	-1.7	0.9
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.6	0.9	1.6	0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.1	0.5	0.6
Systolic blood pressure, automated reading	0.1	0.3	0.5	0.3	-0.7	0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.0	-0.6	0.6	1.0
Angina	2.2	2.9	5.3	2.3	0.2	-1.9
Medication for hormone replacement therapy	0.3	0.3	0.7	0.0	-0.5	0.8
Vitamin and mineral supplements	1.3	1.7	2.6	-1.6	-1.1	1.2
Supplements: Zinc	1.0	1.1	2.3	1.0	-0.4	-1.5
Medication: Co-codamol	0.2	0.3	0.6	0.8	-0.1	-0.5
Medication: Metformin	0.3	0.4	0.9	1.0	0.4	-0.3
Diabetes (father)	0.4	0.5	0.6	0.7	0.7	-0.6
Diabetes (mother)	0.9	1.1	1.4	-0.9	-1.2	1.1
Severe depression (siblings)	1.6	1.8	2.8	-1.7	-0.8	1.4
Pack years adult smoking proportion	0.7	1.1	2.0	1.4	1.0	-0.5
Impedance of leg (right)	0.3	1.7	3.2	-1.3	0.3	1.8
Leg fat-free mass (left)	1.0	5.3	7.0	2.1	2.1	-2.6
Trunk fat percentage	0.0	0.1	0.3	-0.0	-0.6	-0.3
Hand grip strength (right)	1.3	3.5	5.8	0.5	2.4	-2.1
Townsend deprivation index at recruitment	0.3	0.4	0.8	0.9	0.6	0.1
Current tobacco smoking	0.2	0.3	0.4	-0.3	0.7	-0.6
Average weekly fortified wine intake	0.9	1.1	2.5	0.7	-0.5	-1.6
Maternal smoking around birth	0.1	0.2	0.4	-0.3	-0.6	0.4
Fed-up feelings	1.8	3.2	3.6	1.9	1.6	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	3.6	4.8	7.7	1.8	2.8	-1.9
Relative age voice broke	2.9	4.4	5.9	-1.7	-2.1	2.4
Taking other prescription medications	1.0	1.5	4.2	2.0	0.5	0.2
Age when periods started (menarche)	0.1	0.2	0.3	-0.4	-0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	-0.5	1.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.8	13.9	0.7	3.7	-0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.0	0.9	0.7
Qualifications: CSEs or equivalent	1.3	1.7	3.8	0.7	2.0	-0.9
Serious illness, injury or assault to yourself	0.6	0.8	1.3	0.9	-1.1	-0.4
High blood pressure	0.3	0.7	1.9	1.4	-0.5	-0.2
Hayfever, allergic rhinitis or eczema	2.1	4.6	10.7	-0.9	-3.3	1.6
Multivitamins +/- minerals	1.1	1.4	2.1	1.4	1.5	-0.4
Stomach or abdominal pain in last month	0.6	0.8	1.8	0.2	-0.7	-1.3
Supplements: Glucosamine	0.4	0.6	1.0	0.0	1.0	-0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.4	-0.5	-0.4	0.6
Medication: Atenolol	1.4	1.7	3.4	1.3	0.3	-1.9
Medication: Levothyroxine sodium	1.0	1.8	3.9	-2.0	-0.4	1.1
Sitting height	1.6	11.4	24.0	1.7	4.9	-2.7
Chronic bronchitis/emphysema (father)	1.0	1.1	2.4	1.5	-0.9	-0.3
High blood pressure (mother)	0.3	0.4	0.8	-0.9	-0.4	0.6
Body mass index (BMI)	0.2	1.0	2.0	0.4	-0.9	-1.4
Impedance of leg (left)	0.2	1.1	1.8	-1.0	0.7	1.3
Leg predicted mass (left)	1.0	5.2	7.0	2.1	2.1	-2.6
Trunk fat mass	0.1	0.5	1.2	0.5	0.2	-1.1
Waist circumference	0.0	0.1	0.4	0.2	0.0	-0.6
Number of incorrect matches in round	0.9	1.4	1.7	1.2	1.3	-1.1
Past tobacco smoking	0.5	0.9	2.2	-0.4	-1.5	0.5
Alcohol usually taken with meals	0.2	0.3	0.7	-0.1	0.9	-0.3
Nervous feelings	1.1	2.0	3.2	1.8	1.4	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	5.8	0.5	2.4	-1.2
Hearing difficulty/problems with background noise	0.4	0.7	1.6	1.3	-0.3	-0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.2	0.4	0.1
Had menopause	1.0	1.2	1.8	1.2	0.7	1.3
Had other major operations	0.4	0.5	0.8	0.9	0.3	-0.8
Forced vital capacity (FVC)	0.9	3.4	8.1	0.3	2.8	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	11.3	0.9	3.4	-0.1
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	4.2	2.0	1.4	-1.1
Qualifications: None of the above	0.3	0.6	1.0	0.8	1.0	-0.2
Financial difficulties in last 2 years	0.9	1.2	2.3	1.5	0.6	-0.9
Mouth/teeth dental problems	0.3	0.4	0.5	0.7	0.6	0.6
Heart attack	0.9	1.1	1.9	1.0	-0.6	-1.4
Allergy	1.5	3.5	8.0	0.8	2.8	-1.4
Pain all over the body in last month	0.3	0.3	0.8	0.9	-0.4	-0.3
Diabetes (self-reported)	0.8	1.3	2.8	-0.4	-1.7	1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	-0.5	-1.0	-0.1
Medication: Ramipril	2.4	3.1	5.5	2.4	1.1	-1.6
Medication: Simvastatin	0.1	0.2	0.3	0.3	-0.5	0.5
Fluid intelligence score	0.3	0.6	1.5	1.2	0.3	-0.6
Illnesses of siblings	1.4	2.0	3.7	1.2	0.9	-1.9
Neuroticism score	1.2	2.4	5.6	1.0	2.4	-0.8
Weight	0.5	2.6	4.5	1.2	1.4	-2.1
Impedance of arm (right)	0.3	1.3	3.3	-0.5	0.4	1.8
Arm fat percentage (right)	0.2	0.8	1.5	0.5	-1.2	-0.8
Trunk fat-free mass	1.0	5.8	7.0	1.9	2.6	-2.6
Hip circumference	0.6	2.7	5.0	1.7	0.3	-2.2
Time employed in main current job	0.9	1.0	3.0	-0.1	1.7	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.8	-0.3	-1.3	0.2
Father’s age at death	0.1	0.2	0.2	-0.2	-0.5	0.4
Worrier / anxious feelings	0.7	1.3	2.5	-1.2	1.6	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.6	0.0	-0.1
Falls in the last year	0.3	0.4	1.1	-0.3	-1.0	0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	-0.3	-0.6	0.6
Number of live births	0.4	0.5	0.6	0.6	-0.8	0.8
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	5.9	0.0	2.4	-2.0
Pulse rate	0.3	0.5	1.2	1.1	0.3	0.5
Happiness	1.6	1.9	3.2	1.8	1.5	-0.4
Noisy workplace	1.0	1.3	3.3	-1.8	0.1	-0.7
Qualifications: A levels/AS levels or equivalent	0.9	2.1	4.9	-1.1	-2.2	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	5.0	-2.2	-0.7	0.3
Mouth/teeth dental problems: Dentures	0.6	1.1	2.9	-0.6	-1.7	0.2
Asthma	2.2	4.3	7.6	-0.7	-2.8	2.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.1	0.3	0.5	-1.4
Medication: Cholesterol lowering	0.2	0.4	0.6	0.1	-0.7	-0.8
Depression (self-reported)	2.7	3.2	4.4	1.8	1.4	-2.1
Medication: Lansoprazole	4.9	5.6	9.0	1.9	2.0	-3.0
Prospective memory result	0.3	0.3	0.8	-0.2	0.5	-0.9
Lung cancer (father)	0.3	0.3	0.5	0.7	-0.1	-0.6
Illnesses of mother	0.1	0.1	0.2	0.5	0.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	7.7	-0.3	2.8	-1.6
Pulse wave Arterial Stiffness index	0.7	0.8	1.6	1.2	0.8	-0.3
Impedance of arm (left)	0.4	1.7	4.4	-0.8	-0.3	2.1
Arm fat mass (right)	0.2	0.9	1.7	1.0	-0.1	-1.3
Trunk predicted mass	1.0	5.7	6.9	1.9	2.6	-2.5
Standing height	1.0	9.9	23.8	1.8	4.9	-1.6
Length of working week for main job	0.8	0.9	1.7	1.3	0.2	-1.0
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.1	0.4	-0.1
Breastfed as a baby	1.0	1.2	1.5	1.1	1.2	-1.0
Tense / ‘highly strung’	0.4	0.7	1.1	1.1	0.8	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.2	0.5	-0.2	0.5
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.1	0.5	-0.1
Birth weight of first child	0.9	1.7	3.7	-1.9	0.4	1.1
Peak expiratory flow (PEF)	1.2	2.8	5.5	-0.1	2.3	-1.7
Pulse wave reflection index	0.6	0.8	1.6	-0.4	-1.3	0.7
Ever highly irritable/argumentative for 2 days	5.0	6.0	8.3	1.6	2.7	-2.9
Loud music exposure frequency	0.9	1.0	2.9	0.3	0.2	-1.7
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	7.2	-1.6	-2.7	0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.1	-1.0	-0.8	-0.0
Blood clot in the leg (DVT)	0.3	0.3	0.9	-0.1	0.9	-0.3
Medication: Paracetamol	2.1	3.4	6.0	0.8	1.9	-2.5
Headache pain in last month	1.2	2.0	3.1	-0.4	1.8	-1.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.5	0.6	0.4
Glaucoma (self-reported)	0.5	0.6	1.6	-0.3	1.3	0.4
Gout (self-reported)	0.2	0.3	0.8	0.1	-0.9	-0.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.6	-1.6	-0.4	1.4
Medication: Amlodipine	0.9	1.2	1.8	1.0	0.9	-1.4
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.9	-0.0	-1.2	1.4
Birth weight	0.2	0.4	0.8	-0.2	0.9	0.5
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.4	1.2	0.6	-1.5
High blood pressure (siblings)	0.7	1.0	2.1	-0.7	-0.5	1.5
Forced vital capacity (FVC), Best measure	1.0	3.6	9.8	-0.4	3.1	-0.9
Body fat percentage	0.1	0.3	0.7	-0.1	-0.9	-0.4
Leg fat percentage (right)	0.1	0.4	0.7	0.1	-0.8	-0.7
Arm fat-free mass (right)	0.9	4.6	6.0	1.6	2.3	-2.4
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.0	-0.1	-0.5
Comparative body size at age 10	0.2	0.4	0.8	-0.3	-0.9	-0.7
Number of full brothers	0.7	0.9	1.6	-1.1	-0.2	1.3
Worry too long after embarrassment	0.4	0.7	2.1	-0.3	-0.1	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.0	1.4	-0.5	-0.2
Wheeze or whistling in the chest in last year	0.8	1.4	3.6	0.2	-1.9	0.8
Number of children fathered	2.3	2.6	6.3	-2.5	-0.6	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.6	1.6	0.2	-0.4
Age at first live birth	0.5	0.9	1.5	-1.2	-1.0	0.5
Pulse wave peak to peak time	0.3	0.4	0.9	-1.0	-0.4	0.1
Health satisfaction	0.5	0.6	1.7	0.3	1.3	0.4
Shortness of breath walking on level ground	0.9	1.1	1.8	0.5	1.1	-1.3
Qualifications: College or University degree	0.5	1.6	2.3	1.3	0.9	-1.5
Eye problems/disorders: None of the above	0.9	1.0	1.8	0.8	1.3	-0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.7	-0.5	-0.4
Emphysema/chronic bronchitis	1.1	1.3	3.0	0.9	0.0	-1.7
Medication for pain relief, constipation, heartburn	3.1	5.2	8.4	-2.3	-1.3	2.9
Neck or shoulder pain in last month	0.4	0.5	1.1	0.3	0.7	-1.0
Medication: Blood pressure	0.0	0.1	0.2	-0.1	0.4	0.1
Angina (self-reported)	2.3	3.0	4.6	2.1	0.4	-2.0
Migraine (self-reported)	0.3	0.3	0.8	0.2	0.9	0.4
Medication: Ibuprofen	0.4	0.5	1.2	-0.1	0.6	-1.1
Medication: Allopurinol	0.2	0.3	0.4	-0.5	-0.6	0.5
Medication: Omeprazole	3.3	4.0	5.3	2.3	1.6	-2.0
Medication: Seretide 50 evohaler	0.3	0.3	0.5	0.6	-0.7	0.3
Mean time to correctly identify matches	0.4	0.8	1.4	-1.2	-0.7	0.7
Heart disease (mother)	0.4	0.5	1.4	1.2	-0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	-1.1	0.1	0.6
Whole body fat mass	0.2	0.8	1.7	0.9	0.1	-1.3
Leg fat mass (right)	0.2	0.8	2.0	0.7	-0.1	-1.4
Arm predicted mass (right)	0.8	4.0	5.4	1.3	2.2	-2.3
Pulse rate, automated reading	0.2	0.8	2.2	1.5	0.2	0.4
Alcohol intake frequency.	0.1	0.2	0.6	0.0	0.4	-0.8
Comparative height size at age 10	0.9	5.0	8.0	1.8	2.8	-1.9
Number of full sisters	0.7	0.8	1.4	-1.2	0.1	1.0
Suffer from ‘nerves’	2.4	3.7	9.3	3.0	1.2	-0.7
Overall health rating	0.2	0.4	1.2	0.1	-0.2	1.1
Chest pain or discomfort	0.4	0.6	1.0	1.0	-0.6	-0.6
Had major operations	3.1	3.6	7.8	-2.8	-1.5	0.8
Age at last live birth	1.8	2.6	3.8	-1.9	-1.9	0.7
Family relationship satisfaction	1.7	2.1	3.8	1.9	1.5	-0.4
Leg pain on walking	0.6	0.8	1.3	0.9	0.5	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.0	-0.5	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.8	-0.1	-0.9	-0.9
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.5	-0.1	0.4
Medication: Aspirin	0.1	0.1	0.3	0.6	-0.3	0.0
Supplements: Vitamin C	1.9	2.2	2.4	1.6	1.4	-1.5
Knee pain experienced in last month	0.6	1.0	2.8	-1.7	-0.1	-0.3
Hypertension (Self-reported)	0.3	0.9	2.1	1.4	-0.6	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	5.3	1.0	1.4	-2.3
Illnesses of father: Heart disease	2.1	3.0	4.1	1.8	1.3	-2.0
Illnesses of siblings: Diabetes	0.3	0.3	0.9	0.1	-0.0	1.0
Smoking status: Previous	0.5	0.8	2.0	0.7	1.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.0	-0.3	2.0	-1.2
Whole body fat-free mass	1.0	5.8	7.1	2.0	2.5	-2.7
Leg fat-free mass (right)	1.0	5.4	6.9	2.1	2.2	-2.6
Arm fat percentage (left)	0.2	0.8	1.8	0.4	-1.3	-0.6
Average weekly red wine intake	0.9	1.3	2.0	0.1	-1.4	1.4
Handedness (chirality/laterality): Left-handed	1.5	1.7	3.0	1.3	1.7	-0.7
Mood swings	0.4	0.8	2.3	0.2	1.5	-0.3
Loneliness, isolation	1.5	2.1	4.3	1.1	2.1	-0.8
Long-standing illness, disability or infirmity	0.2	0.3	0.5	0.5	-0.5	0.7
Ever had bowel cancer screening	2.4	2.8	3.0	-1.6	-1.7	1.7
Diabetes diagnosed by doctor	0.5	0.8	1.9	0.1	-1.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.1	1.1	1.4	-1.5
Friendships satisfaction	0.3	0.3	0.9	0.9	-0.3	0.3
Qualifications: nursing, teaching	3.8	6.0	7.4	-2.7	-2.2	2.3
Commuting to job workplace: Walk	0.0	0.1	0.1	-0.4	0.0	0.2
Eye problems/disorders: Cataract	0.5	0.6	0.8	-0.9	-0.8	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.1	0.1	0.1	-1.1
Medication for cholesterol	1.0	1.6	4.5	-2.1	-0.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	0.2	0.5	0.8
Back pain experienced in last month	0.1	0.1	0.2	0.5	-0.0	-0.1
Mineral and other dietary supplements	2.0	2.7	4.1	-2.0	-1.6	1.2
Breast cancer (self-reported)	1.9	2.2	5.3	-0.8	-2.3	0.9
Asthma (self-reported)	2.4	4.7	9.3	-0.6	-3.0	2.1
Osteoporosis (self-reported)	2.3	2.8	3.6	-1.4	-1.7	1.9
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.1	0.5	-0.7
Medication: Aspirin	0.0	0.1	0.1	0.2	-0.3	-0.2
Medication: Gliclazide	0.3	0.4	0.7	0.7	0.2	0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.2	0.1	0.7
Smoking status: Current	0.3	0.5	0.8	-0.3	0.8	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.2	0.3	0.7	-1.1
Whole body water mass	1.0	5.7	7.1	2.0	2.4	-2.7
Leg predicted mass (right)	1.0	5.2	6.6	2.1	2.2	-2.6
Arm fat mass (left)	0.3	1.0	1.8	1.1	0.0	-1.4
Number of self-reported non-cancer illnesses	0.8	1.4	2.7	1.6	-1.2	-0.1
Average weekly champagne plus white wine intake	0.9	1.3	3.6	0.3	-1.9	0.3
Miserableness	0.4	0.7	1.1	1.1	0.6	-0.7
Guilty feelings	0.9	1.4	2.7	1.6	1.3	0.0
Wears glasses or contact lenses	0.7	0.8	1.9	-1.4	0.4	0.5
Ever taken oral contraceptive pill	0.9	1.0	1.3	-1.0	-1.1	0.8
Hearing aid user	1.0	1.1	2.2	-1.0	-0.3	1.5
Mother’s age at death	0.3	0.3	0.9	-1.0	0.1	0.1
Financial situation satisfaction	5.4	6.7	14.3	1.8	3.8	-1.6
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.6	1.3	1.2	-0.6
Commuting to job workplace: Public transport	0.5	0.6	1.6	-0.2	1.3	-0.3
Eye problems/disorders: Glaucoma	0.8	0.9	1.7	-0.9	1.3	0.5
Medication: Blood pressure	0.8	1.6	3.1	1.8	0.7	-1.1
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.3	0.6	0.3	-0.4
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.0	1.4	1.0	0.2
High cholesterol (Self-reported)	0.0	0.1	0.1	0.3	0.0	0.3
Medication: Bendroflumethiazide	1.1	1.6	3.3	1.0	1.8	-0.7
Medication: Paracetamol	2.8	4.3	6.8	1.3	2.1	-2.6
Medication: Lisinopril	0.1	0.2	0.3	0.1	-0.6	-0.5
Medication: Atorvastatin	0.4	0.5	1.4	1.2	0.1	-0.1
Illnesses of father: High blood pressure	2.1	2.6	3.4	1.9	1.8	-1.2
Alcohol drinker status: Never	0.2	0.2	0.3	-0.6	-0.4	0.0
Ever smoked	1.0	1.7	4.3	0.5	2.1	-0.7
Basal metabolic rate	1.0	5.5	7.2	2.0	2.4	-2.7
Leg fat percentage (left)	0.2	0.6	1.3	0.5	-0.6	-1.2
Arm fat-free mass (left)	1.2	6.1	6.9	2.2	2.6	-2.6
Number of operations (self-reported)	0.3	0.5	1.1	-1.1	-0.4	-0.5
Average weekly beer plus cider intake	5.5	7.9	10.9	3.3	1.5	-3.3
Irritability	0.6	1.1	1.7	0.6	1.3	-1.1
Risk taking	0.2	0.3	0.4	0.6	0.2	-0.7
Ever had prostate specific antigen (PSA) test	1.6	1.9	2.9	-1.7	-1.0	1.3
Fractured/broken bones in last 5 years	4.2	5.4	8.6	-1.6	-2.9	2.3
Age started oral contraceptive pill	0.7	0.8	1.3	-1.1	-0.1	1.1
Diastolic blood pressure, automated reading	0.6	1.8	2.9	1.7	-0.0	-1.6
Ever depressed for a whole week	1.1	1.3	2.2	0.9	1.0	-1.5
Unable to work because of sickness or disability	0.3	0.4	1.1	1.0	0.2	0.1
Commuting to job workplace: Cycle	2.1	2.5	4.1	1.8	2.0	-0.5
Myopia	0.6	0.9	1.9	-0.4	0.8	1.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.4	-1.5	1.1	0.6
Cholesterol lowering medication	0.3	0.5	0.8	0.9	-0.2	0.8
Medication: Omeprazole (e.g. Zanprol)	3.8	4.6	6.0	2.3	1.6	-2.5
Pain experienced in last month	1.3	2.2	5.0	-1.3	-0.4	2.2
Supplements: Calcium	1.9	2.1	4.0	2.0	-0.4	-1.5
Basal cell carcinoma (self-reported)	2.0	2.4	6.0	0.9	-2.5	0.7
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.8	0.9	-0.5	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.8	-0.2	0.9	-0.3
Heart disease (siblings)	0.6	0.8	2.1	0.3	-1.4	-0.4
Alcohol drinker status: Previous	1.1	1.2	3.5	-0.4	-1.9	-0.3
Pack years of smoking	0.4	0.6	0.9	0.9	0.9	-0.0
Impedance of whole body	0.3	1.4	3.0	-1.0	0.5	1.7
Leg fat mass (left)	0.4	1.4	3.1	1.0	0.2	-1.8
Arm predicted mass (left)	1.2	5.9	7.3	1.9	2.6	-2.7